metaR DHEAtr
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: 2.8.2.2 Confidence Level: 1 AUTHORS: PMID:11535246,PMID:1588921 NOTES:
name: Dehydroepiandrosterone transport
type: Reaction
product: MODEL1310110027#

metaR r2086
is described by: ECO:0000000
fast: false
modifier: MODEL1310110027#
reversible: true
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185

metaM gdpddman c
is: CHEBI:57964
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB01346
has only substance units: false
type: Species
notes: FORMULA: C16H21N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H23N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,8-11,14-15,23-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00728 EHMN_ABBREVIATION: C01222
name: GDP-4-dehydro-6-deoxy-alpha-D-mannose(2-)
initial concentration: 1.0
boundary condition: false

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

metaM 3hpcoa m
constant: false
has only substance units: false
name: 3-hydroxypropanoyl-CoA(4-)
initial concentration: 1.0
type: Species
is: CHEBI:58528
is: HMDB06807
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
boundary condition: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_65cb4e13_b049_4a05_a0ba_ea2e70d9f014
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: P49753
is: SBO:0000252
is encoded by: hsa:10965
boundary condition: true
initial concentration: NaN
name: ACOT2

metaR NH4t3r
product: MODEL1310110027#
kinetic law: MODEL1310110027#
name: ammonia transport via proton antiport
type: Reaction
is: SBO:0000185
reversible: true
modifier: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
fast: false

metaR AACOAT
reactant: MODEL1310110027#
reversible: true
notes: GENE_ASSOCIATION: (65985.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.16 Confidence Level: 4 AUTHORS: PMID:12623130 NOTES:also EC 2.8.3.8 NCD
modifier: MODEL1310110027#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110027#
is: SBO:0000176
name: Acetoacetyl-CoA:acetate CoA-transferase
is version of: http://identifiers.org/ec-code/6.2.1.16
product: MODEL1310110027#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_0858b387_170e_471b_9c09_77d7210f45de
is encoded by: hsa:131
name: ADH7
type: Species
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: P40394
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110027#_f7a7f0ab_0a92_42cc_9b4a_a533902b71aa
type: Species
constant: false
initial amount: NaN
name: IVD
initial concentration: NaN
is: B3KVI7
is encoded by: hsa:3712
is: SBO:0000252
has only substance units: false
boundary condition: true

metaM ahcys m
initial amount: NaN
has only substance units: false
is: CHEBI:16680
is: HMDB00939
is: SBO:0000247
name: S-Adenosyl-L-homocysteine
is: C00021
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
type: Species

metaR LEUKTRE4t
reactant: MODEL1310110027#
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110027#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false
name: leukotriene E4 transport

http://identifiers.org/biomodels.db/MODEL1310110027#_d852b5b6_ab8f_4aa2_a0ea_d0c070ac6252
is: SBO:0000252
is encoded by: hsa:56848
is: Q9NRA0
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: SPHK2
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_25f87787_5930_453d_ab95_9f1fb81ba15b
has only substance units: false
initial amount: NaN
is encoded by: hsa:51251
is: Q9H0P0
is: SBO:0000252
boundary condition: true
type: Species
name: NT5C3
constant: false
initial concentration: NaN

metaR CYTK10
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110027#
is described by: ECO:0000269
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
fast: false
reversible: true
name: cytidylate kinase (CMP,dGTP)
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
type: Reaction

metaR KCCt
type: Reaction
kinetic law: MODEL1310110027#
name: K+-Cl- cotransport
fast: false
reactant: MODEL1310110027#
is described by: ECO:0000269
product: MODEL1310110027#
modifier: MODEL1310110027#
is: SBO:0000185
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD
reversible: true

metaM CE5788 e
name: kinetensin 1-7
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
type: Species
is: CHEBI:27485
is: HMDB02710

metaR r0885
product: MODEL1310110027#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.3.1.38
reactant: MODEL1310110027#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
fast: false
modifier: MODEL1310110027#

metaM h2o c
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB02111
is: CHEBI:3303
is: C00001
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
name: H2O
notes: FORMULA: H2O CHARGE: 0

metaR SMPD4
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ
kinetic law: MODEL1310110027#
is: SBO:0000176
name: sphingomyelinase
reversible: false
type: Reaction
fast: false
product: MODEL1310110027#
reactant: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_aa34e945_5c39_465b_8c3f_c3ad7848282c
has only substance units: false
constant: false
type: Species
is encoded by: hsa:6566
is: SBO:0000252
initial concentration: NaN
is: B4DKS0
initial amount: NaN
name: SLC16A1
boundary condition: true

metaM mi4p D c
type: Species
is: CHEBI:58469
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3-,4+,5-,6-/m0/s1
name: 1D-myo-inositol 4-phosphate(2-)
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB01313

metaR FUMm
type: Reaction
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: PMID:16774737,PMID:17111171,PMID:17111172 NOTES:IF. Biochemical
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.2
name: fumarase, mitochondrial
reversible: true
reactant: MODEL1310110027#
is described by: ECO:0000134
kinetic law: MODEL1310110027#
is: SBO:0000176
product: MODEL1310110027#
modifier: MODEL1310110027#

metaR ARGtiDF
notes: GENE_ASSOCIATION: (6541.1) or (6542.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
name: L-arginine transport via diffusion (extracellular to cytosol)
is: SBO:0000185
product: MODEL1310110027#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110027#
type: Reaction
reversible: false
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_5e37a59a_5293_485a_8249_b6c71e011ce0
initial concentration: NaN
constant: false
is encoded by: hsa:226
boundary condition: true
has only substance units: false
is: P04075
is: SBO:0000252
initial amount: NaN
type: Species
name: ALDOA

metaM 4hglusa m
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
name: L-4-hydroxyglutamic semialdehyde
type: Species
is: CHEBI:27809
has only substance units: false
is: SBO:0000247
is: HMDB06556
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938

metaR r2085
fast: false
is: SBO:0000185
kinetic law: MODEL1310110027#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110027#
reversible: true
type: Reaction
product: MODEL1310110027#
modifier: MODEL1310110027#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110027#_ca3db243_3e3d_4c27_a19b_c81429d27b0d
initial concentration: NaN
boundary condition: true
name: MCCC2
has only substance units: false
type: Species
is: Q9HCC0
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:64087
constant: false

metaM dttp n
is: C00459
boundary condition: false
has only substance units: false
type: Species
name: dTTP
is: HMDB01342
constant: false
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
initial concentration: 1.0
initial amount: NaN
is: CHEBI:37568
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_035b6977_a4eb_486e_bd9d_c60db98d2ca8
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:4842
is: B4DG68
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: NOS1

metaM 13dampp c
type: Species
notes: FORMULA: C3H12N2 CHARGE: 2 INCHI: InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2/p+2 EHMN_ABBREVIATION: C00986
name: trimethylenediaminium
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:57484
is: HMDB00002
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110027#_84eb0f33_cac5_4fe6_86d1_c98325a9097d
is: SBO:0000252
type: Species
name: DGKA
initial amount: NaN
is: P23743
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:1606
initial concentration: NaN

metaR G14T8g
fast: false
product: MODEL1310110027#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110027#
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110027#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110027#_d50fca22_e9ca_4c29_8e6b_a73f137699ee
type: Species
is encoded by: hsa:84105
constant: false
name: PCBD2
boundary condition: true
initial concentration: NaN
is: Q9H0N5
initial amount: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110027#_fc5d9446_aefa_4a91_a38e_43e65be49530
boundary condition: true
has only substance units: false
is encoded by: hsa:25902
initial amount: NaN
initial concentration: NaN
is: B2RD24
type: Species
constant: false
is: SBO:0000252
name: MTHFD1L

metaR MTHFCm
fast: false
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/6.3.4.3
is version of: http://identifiers.org/ec-code/3.5.4.9
name: methenyltetrahydrifikate cyclohydrolase, mitochondrial
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#

metaR ACt2r
is described by: ECO:0000000
product: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
name: acetate reversible transport via proton symport
reactant: MODEL1310110027#
is: SBO:0000185

metaR r0142
product: MODEL1310110027#
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110027#
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
kinetic law: MODEL1310110027#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.5
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110027#_799fcbbe_cdce_482d_a70d_2c3548816760
name: ACP6
constant: false
initial concentration: NaN
is: Q9NPH0
boundary condition: true
is encoded by: hsa:51205
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN

metaR PGMT
kinetic law: MODEL1310110027#
is: SBO:0000176
name: phosphoglucomutase
modifier: MODEL1310110027#
reactant: MODEL1310110027#
type: Reaction
reversible: true
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (5236.1) or (55276.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.4.2.2 Confidence Level: 0 AUTHORS: PMID:4829444 NOTES:
is version of: http://identifiers.org/ec-code/5.4.2.2
is described by: ECO:0000134
fast: false

http://identifiers.org/biomodels.db/MODEL1310110027#_23da2f9f_ea43_437f_90a6_ddc69856c136
has part: P50213
is encoded by: hsa:3421
boundary condition: true
initial concentration: NaN
is: SBO:0000297
has part: E9PDD5
initial amount: NaN
is encoded by: hsa:3420
constant: false
has only substance units: false
is encoded by: hsa:3419
type: Species
name: IDH3A:IDH3B:IDH3G

metaR r2084
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110027#
is described by: ECO:0000000
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
reactant: MODEL1310110027#
fast: false
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_f2c06c0a_53bf_4591_b255_b5be84faa070
name: GMPR
initial amount: NaN
is: P36959
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:2766
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110027#_cd8c8322_f211_46db_8bf9_8e8bf1ffe38e
is: Q4F7X0
name: ADCY8
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:114

http://identifiers.org/biomodels.db/MODEL1310110027#_d07fcece_3993_4a3f_ad5c_6bbd11d6758e
is: SBO:0000252
name: NDUFB1
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is: O75438
type: Species
is encoded by: hsa:4707
has only substance units: false

metaM dgmp m
initial concentration: 1.0
is: HMDB01044
is: C00362
type: Species
is: CHEBI:57673
initial amount: NaN
name: dGMP
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362

metaM ksii core4 deg2 l
is: SBO:0000247
is: HMDB00143
name: keratan sulfate II (core 4-linked), degradation product 2
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C78H127N6O61S2X CHARGE: -2
is: CHEBI:12936
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_96c9e53c_fb82_4a14_9e95_860e8c412116
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1807
name: DPYS
is: Q14117
initial concentration: NaN
type: Species

metaM Rtotalcoa c
is: CHEBI:16189
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
type: Species
constant: false
is: HMDB01448
initial concentration: 1.0
name: R total Coenzyme A

http://identifiers.org/biomodels.db/MODEL1310110027#_63ce3004_31c7_4fd7_bc94_8a05ff00d6b2
is: SBO:0000252
initial concentration: NaN
constant: false
is: O95498
has only substance units: false
name: VNN2
is encoded by: hsa:8875
boundary condition: true
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_5845fa15_b1ac_4f5f_8760_bef4f5892c85
is encoded by: hsa:276
constant: false
initial amount: NaN
is: Q6NSB3
type: Species
is: SBO:0000252
name: AMY1A
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR ST8SIA12
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
modifier: MODEL1310110027#
product: MODEL1310110027#
kinetic law: MODEL1310110027#
reversible: false
is: SBO:0000176
fast: false
name: Beta-galactoside alpha-2,3-sialyltransferase
is version of: http://identifiers.org/ec-code/2.4.99.8
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_f62f4dc9_4a18_474c_9316_9746aa63869f
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
is: P27144
type: Species
boundary condition: true
has only substance units: false
name: AK4
is encoded by: hsa:205

http://identifiers.org/biomodels.db/MODEL1310110027#_0c935ba6_ffff_4353_962d_eb84e9b5fd2e
type: Species
name: PIGL
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
is: Q9Y2B2
has only substance units: false
boundary condition: true
is encoded by: hsa:9487

metaR RE3568C
fast: false
reversible: true
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
name: RE3568
is: SBO:0000176
type: Reaction
product: MODEL1310110027#
kinetic law: MODEL1310110027#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110027#_87068771_552c_4dc4_bd28_b6627050eade
constant: false
initial amount: NaN
initial concentration: NaN
is: P33908
boundary condition: true
name: MAN1A1
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:4121

metaM h2o e
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
is: HMDB02111
name: H2O
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: CHEBI:15377
is: C00001
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110027#_b7b1376b_c231_42a7_9522_4897425cb6ce
is: SBO:0000252
name: HMGCS2
type: Species
initial amount: NaN
is encoded by: hsa:3158
is: P54868
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true

metaM 2mb2coa m
is: SBO:0000247
initial amount: NaN
is: HMDB02054
initial concentration: 1.0
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
name: 2-methylcrotonoyl-CoA(4-)
constant: false
type: Species
has only substance units: false
is: CHEBI:57337
boundary condition: false

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

metaR RE1527M
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110027#
product: MODEL1310110027#
modifier: MODEL1310110027#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
type: Reaction
name: RE1527

http://identifiers.org/biomodels.db/MODEL1310110027#_bea31211_1d30_4233_9a49_1df85ced98c9
is encoded by: hsa:AI348006
constant: false
has only substance units: false
type: Species
name: _AI348006_1_c
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR r2083
is described by: ECO:0000000
kinetic law: MODEL1310110027#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reversible: true
reactant: MODEL1310110027#
modifier: MODEL1310110027#
product: MODEL1310110027#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_597e5ceb_ac48_449a_b56f_10ef3b273793
name: PDE1A
initial amount: NaN
has only substance units: false
is encoded by: hsa:5136
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is: P54750

http://identifiers.org/biomodels.db/MODEL1310110027#_6ca1de1a_d85f_4654_b653_543d59041802
initial amount: NaN
is encoded by: hsa:4718
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: Q549M5
name: NDUFC2
constant: false

metaM dutp n
type: Species
is: CHEBI:17625
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
name: dUTP
is: HMDB01191
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
initial amount: NaN

metaR FAOXC164m
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)m
type: Reaction

metaR CYTK7n
is: SBO:0000176
kinetic law: MODEL1310110027#
name: cytidylate kinase (CMP,UTP),nuclear
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110027#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110027#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_4580b891_b215_4614_b246_05f18942c38d
is encoded by: hsa:2877
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
boundary condition: true
has only substance units: false
is: P18283
name: GPX2
initial concentration: NaN

metaM hxan e
has only substance units: false
name: hypoxanthine
initial concentration: 1.0
is: HMDB00157
type: Species
initial amount: NaN
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
constant: false
boundary condition: false
is: CHEBI:17368
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_df7a699b_5ea4_4eda_a8af_9f65af906149
name: GPAA1
constant: false
boundary condition: true
is encoded by: hsa:8733
type: Species
is: SBO:0000252
is: O43292
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR r0990
product: MODEL1310110027#
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
kinetic law: MODEL1310110027#
is: SBO:0000185
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110027#

metaR DURAD
is: SBO:0000176
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
type: Reaction
reactant: MODEL1310110027#
name: dihydrouracil dehydrogenase (NADP)
modifier: MODEL1310110027#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.1.2
fast: false
kinetic law: MODEL1310110027#
reversible: true
product: MODEL1310110027#

metaM s2l2n2m2m l
is: CHEBI:57312
has only substance units: false
notes: FORMULA: C84H136N6O62 CHARGE: -2
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: de-Fuc form of PA6 (w/o peptide linkage)
is: HMDB01356
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_46e41fdf_3c79_4c93_bb48_85e163ee34a3
is: O00746
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
name: NME4
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4833

metaM ps hs c
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:18303
name: ps_hs[c]
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
is: SBO:0000247
has only substance units: false

metaR DOPAtu
modifier: MODEL1310110027#
product: MODEL1310110027#
fast: false
type: Reaction
is described by: ECO:0000269
name: Dopamine uniport
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
is: SBO:0000185
reversible: true

metaR LNLNCGt
fast: false
kinetic law: MODEL1310110027#
is: SBO:0000185
type: Reaction
reversible: true
name: fatty acid transport via diffusion
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
reactant: MODEL1310110027#

metaR UPPN
is described by: ECO:0000269
is: SBO:0000176
fast: false
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:10542323,PMID:12450676 NOTES:SAB balanced
name: b-ureidopropionase
reversible: false
modifier: MODEL1310110027#
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.5.1.6

http://identifiers.org/biomodels.db/MODEL1310110027#_63dba4c2_4cb2_4983_a987_973082392fa1
is: SBO:0000252
initial concentration: NaN
is: G3V4L5
has only substance units: false
name: SLC25A21
type: Species
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:89874

metaM didp c
has only substance units: false
type: Species
constant: false
name: dIDP
is: HMDB03536
initial concentration: 1.0
is: CHEBI:28823
boundary condition: false
initial amount: NaN
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_d5365ce0_dfdb_4e90_b7e2_823bbfd280d3
type: Species
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:91373
is: Q3KQV9
name: UAP1L1

metaR H2Otly
product: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: H2O transport, lysosomal
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
is described by: ECO:0000000

metaR RE1573M
reversible: true
name: RE1573
kinetic law: MODEL1310110027#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
modifier: MODEL1310110027#
product: MODEL1310110027#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/5.3.3.8
fast: false

metaR r2082
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
reactant: MODEL1310110027#
type: Reaction
reversible: true
product: MODEL1310110027#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110027#_bdca9086_82ac_4765_8873_eeebe6d1c647
is: Q9H6R3
constant: false
name: ACSS3
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:79611
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110027#_5aa49442_88b7_4442_8dda_9a372e4e6243
is: P48448
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:222
constant: false
name: ALDH3B2
boundary condition: true
initial concentration: NaN

metaR r2081
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110027#
type: Reaction
modifier: MODEL1310110027#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110027#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110027#

metaR EX tdchola LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: taurochenodeoxycholate exchange
type: Reaction

metaM CE2424 m
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:28387
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB11123
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424
type: Species
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110027#_f62dc7c1_ebfd_4cd7_92c6_9885dc175e5b
is: P40926
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: MDH2
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:4191

metaR r0881
product: MODEL1310110027#
reversible: false
name: Active transport
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12107270,PMID:12739169,PMID:12829793,PMID:17245649,PMID:18375207,PMID:8476015,PMID:8557697,PMID:9786900 NOTES:
reactant: MODEL1310110027#
is: SBO:0000185

metaR PYRt2m
kinetic law: MODEL1310110027#
reversible: true
product: MODEL1310110027#
fast: false
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD
type: Reaction
name: pyruvate mitochondrial transport via proton symport
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110027#

metaR GDPtg
type: Reaction
product: MODEL1310110027#
kinetic law: MODEL1310110027#
name: GDP intracellular transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - likely translocated, unknown transporter/mechanism though NJ
is described by: ECO:0000000
fast: false
reactant: MODEL1310110027#
is: SBO:0000185

metaR G14T21g
is: SBO:0000176
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
reversible: false
reactant: MODEL1310110027#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110027#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_f17001a5_1ae1_454e_9033_59ba7ac217f5
boundary condition: true
has only substance units: false
constant: false
name: COX6B1
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1340
is: P14854

http://identifiers.org/biomodels.db/MODEL1310110027#_bc20c606_da5a_4efc_b2c3_f669c547be67
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:AA526438
has only substance units: false
boundary condition: true
initial concentration: NaN
name: _AA526438_1_c
is: SBO:0000252

metaM 13 cis retn n
type: Species
is: http://identifiers.org/pubchem.compound/7847414
is: D00348
name: 13-cis-retinoate
boundary condition: false
initial amount: NaN
is: HMDB06219
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0

metaR r1923
reversible: false
fast: false
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
product: MODEL1310110027#
type: Reaction
modifier: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_88b68df3_5b63_44c3_97f8_ba6f9cf28151
name: SLC38A1
boundary condition: true
is encoded by: hsa:81539
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
is: Q9H2H9
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_50a26760_eb43_4aa1_b916_a4da59296e84
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: GALNT10
type: Species
is: Q86SR1
constant: false
boundary condition: true
is encoded by: hsa:55568

metaR r0669
kinetic law: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
reactant: MODEL1310110027#
fast: false
is: SBO:0000176
product: MODEL1310110027#
is described by: ECO:0000000
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
reversible: false

metaR SQLSr
is version of: http://identifiers.org/ec-code/2.5.1.21
name: Squalene synthase
product: MODEL1310110027#
is: SBO:0000176
fast: false
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ
is described by: ECO:0000134
modifier: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#
reversible: false

metaR G14T15g
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reactant: MODEL1310110027#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
product: MODEL1310110027#
is: SBO:0000176
fast: false
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.22
modifier: MODEL1310110027#

metaM tcynt e
initial amount: NaN
is: CHEBI:18022
type: Species
is: SBO:0000247
is: HMDB01453
boundary condition: false
constant: false
name: thiocyanate
initial concentration: 1.0
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_537bf490_6ddc_46f8_9b3e_8cf0cdefcffe
is encoded by: hsa:6536
is: B7Z3W8
initial concentration: NaN
is: SBO:0000252
constant: false
name: SLC6A9
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false

metaR DHCR72r
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.3.1.21
name: 7-dehydrocholesterol reductase
is described by: ECO:0000269
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
fast: false
is: SBO:0000176
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_5e8cf30e_9ecb_4610_b993_f2dcecd3a13c
type: Species
is: SBO:0000252
name: ITPKB
is: P27987
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:3707
constant: false
initial concentration: NaN

metaM thp2c c
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
is: HMDB12130
name: 1-piperideine-6-carboxylate
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16987

metaR r2080
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
product: MODEL1310110027#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110027#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110027#_0390cbf1_8f49_42dd_ad01_85c34b9e3cb6
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:27068
is: SBO:0000252
name: PPA2
type: Species
constant: false

metaR GLUTCOADHm
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (2639.1) or (2639.2) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 2 AUTHORS: NOTES:SAB use of FAD is not certain
is described by: ECO:0000304
fast: false
name: glutaryl-CoA dehydrogenase (mitochondria)
is: SBO:0000176
reversible: false
type: Reaction
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.3.99.7
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#

metaR SUCOASm
name: Succinate--CoA ligase (ADP-forming)
product: MODEL1310110027#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.4
fast: false
type: Reaction
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/6.2.1.5
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD

metaR r0210
fast: false
is: SBO:0000176
is described by: ECO:0000000
name: L-Serine hydro-lyase (adding homocysteine) Glycine, serine and threonine metabolism EC:4.2.1.22
product: MODEL1310110027#
reactant: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 4.2.1.22 Confidence Level: 0 AUTHORS: PMID:681363 NOTES:
reversible: false
kinetic law: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_19d19c4f_fd70_4981_8422_345a9b25d6f1
type: Species
is: SBO:0000252
boundary condition: true
name: DGUOK
initial amount: NaN
is encoded by: hsa:1716
initial concentration: NaN
has only substance units: false
constant: false
is: Q16854

metaR ORNt3m
kinetic law: MODEL1310110027#
reversible: true
is described by: ECO:0000269
name: ornithine mitochondrial transport via proton antiport
reactant: MODEL1310110027#
is: SBO:0000185
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
fast: false
product: MODEL1310110027#
type: Reaction

metaR PROSTGE2t2
name: prostaglandin uniport
reactant: MODEL1310110027#
fast: false
kinetic law: MODEL1310110027#
is described by: ECO:0000269
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
type: Reaction
reversible: true
product: MODEL1310110027#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110027#_c4eb4804_4635_4a80_b8c8_95284371c089
initial amount: NaN
is: Q9BRC7
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:84812
constant: false
initial concentration: NaN
type: Species
name: PLCD4

metaM ps hs e
type: Species
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:18303
name: phosphatidylserine
is: SBO:0000247
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006

metaR S6T12g
type: Reaction
modifier: MODEL1310110027#
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (23563.1) or (9435.1) or (10164.1) or (4166.1) or (23563.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
reactant: MODEL1310110027#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110027#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110027#_0a68584c_2d09_4ab6_98fe_440bd0ea3b18
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6542
type: Species
is: SBO:0000252
has only substance units: false
name: SLC7A2
initial amount: NaN
constant: false
is: P52569

metaR 3AIB Dtm
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: no transporter could be identified, so diffusion is assumed. NOTES:
is: SBO:0000185
reactant: MODEL1310110027#
product: MODEL1310110027#
is described by: ECO:0000134
fast: false
name: transport of 3aib_D into mitochondria
kinetic law: MODEL1310110027#
type: Reaction

metaM ksii core2 pre8 g
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 8
boundary condition: false
constant: false
is: HMDB00175
notes: FORMULA: C75H121N6O56SX CHARGE: -2
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:58053
initial concentration: 1.0
is: C00130

metaR GLYC3PFADm
reversible: false
kinetic law: MODEL1310110027#
type: Reaction
is: SBO:0000176
is described by: ECO:0000134
fast: false
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110027#
name: glycerophosphate shuttle for trasnfer of reducing equivalents

metaM ha pre1 e
name: hyaluronan biosynthesis, precursor 1
is: CHEBI:16126
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247

metaR PI4P3K
fast: false
is described by: ECO:0000000
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.11.1
type: Reaction
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5296.1 and 5290.1) or (5293.1 and 5296.1) or (5287.1) or (5286.1) or (5293.1 and 8503.1) or (5293.1 and 5295.3) or (5291.1 and 8503.1) or (5295.2 and 5290.1) or (5288.1) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (23533.1 and 5294.1) or (5293.1 and 5295.1) or (5295.2 and 5293.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (10870.1 and 5294.1) or (5295.2 and 5291.1) or (5290.1 and 5295.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD Notice that contrary to some standards in texts, KEGG, etc, the Rtotal group accounts for the whole fatty acyl CoA (so the CHO only accounts for the core backbone), manner in which Rtotal was produced accounts for O and H balances. Formation of the Rtotal group (rxn flux)accounted for mass balance for CoA NJ changed EC from 2.7.1.149 (pail5p) to 2.7.1.68 (pail4p) - NCD
reversible: false
is: SBO:0000176
name: phosphatidylinositol 4-phosphate 3-kinase
is version of: http://identifiers.org/ec-code/2.7.1.154
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.1.153

metaR AG13T3g
reversible: false
product: MODEL1310110027#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
notes: GENE_ASSOCIATION: (10331.1) or (11041.1) or (374907.2) or (10678.1) or (79369.1) or (374907.1) or (10678.2) or (93010.1) or (146712.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110027#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110027#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110027#

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

metaR RE3326M
kinetic law: MODEL1310110027#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110027#
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.2.4.4
type: Reaction
name: RE3326
reversible: true
notes: GENE_ASSOCIATION: (594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:2699399,PMID:9665099 NOTES:
is: SBO:0000176
product: MODEL1310110027#

metaM sebcoa c
initial concentration: 1.0
is: HMDB04047
constant: false
has only substance units: false
is: C14143
boundary condition: false
is: SBO:0000247
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
name: sebacoylcoa
initial amount: NaN
type: Species

metaR EX c8dc
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for suberyl carnitine
type: Reaction

metaM ppcoa m
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: Propanoyl-CoA
is: HMDB01275
is: C00100
constant: false
initial amount: NaN
is: CHEBI:57392
boundary condition: false
type: Species

metaR r1810
reversible: false
name: Y+LAT2 Utilized transport
type: Reaction
kinetic law: MODEL1310110027#
product: MODEL1310110027#
is: SBO:0000185
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110027#
fast: false

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

metaR GALtly
kinetic law: MODEL1310110027#
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110027#
name: galactose efflux from lysosome
reversible: false
product: MODEL1310110027#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD

metaM CE5786 e
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
is: SBO:0000247
is: HMDB02710
is: CHEBI:27485
name: kinetensin
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_f9f91cb5_756d_4d32_8a79_8067db943b85
type: Species
is: P23378
is encoded by: hsa:2731
name: GLDC
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110027#_f893698d_7886_4528_96c8_0a6db8ba4ea1
name: ACOX1
is encoded by: hsa:51
boundary condition: true
is: SBO:0000252
has only substance units: false
is: B4DK61
constant: false
initial concentration: NaN
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_998bfdd0_9d0f_486d_856a_7857ffec613f
name: NDUFA11
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:126328
is: SBO:0000252
initial amount: NaN
is: C9JT23
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110027#_adadb289_0054_44ab_857c_d089e6d884d6
is: SBO:0000252
name: ST3GAL3
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6487
is: Q5T4W8
constant: false

metaM octe5coa m
is: SBO:0000247
name: 5-octenoylcoa
constant: false
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN
type: Species
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaM betald c
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
is: HMDB01252
is: SBO:0000247
has only substance units: false
is: CHEBI:15710
constant: false
boundary condition: false
name: betaine aldehyde
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_edfcfb42_4098_4b95_841c_c5551b3073bb
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
constant: false
name: PIGN
is encoded by: hsa:23556
has only substance units: false
is: SBO:0000252

metaR TRIODTHYt2
kinetic law: MODEL1310110027#
fast: false
is described by: ECO:0000269
is: SBO:0000185
name: T3 transport via facilitated diffusion
type: Reaction
product: MODEL1310110027#
reversible: true
reactant: MODEL1310110027#
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ

metaM HC00822 l
name: Chitobiose
initial concentration: 1.0
notes: FORMULA: C16H28N2O11 CHARGE: 0 INCHI: InChI=1S/C16H28N2O11/c1-5(21)17-9-13(25)14(8(4-20)27-15(9)26)29-16-10(18-6(2)22)12(24)11(23)7(3-19)28-16/h7-16,19-20,23-26H,3-4H2,1-2H3,(H,17,21)(H,18,22)/t7-,8-,9-,10-,11-,12-,13-,14-,15?,16+/m1/s1 EHMN_ABBREVIATION: C01674
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:28681

http://identifiers.org/biomodels.db/MODEL1310110027#_7d119870_0ac4_47f4_8655_492665fc7cef
initial amount: NaN
constant: false
is: Q16222
has only substance units: false
name: UAP1
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:6675

metaR r0994
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
name: Facilitated diffusion
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110027#
type: Reaction
reactant: MODEL1310110027#
fast: false
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_35f8aaa3_0d0a_4146_bd9a_4170544bb3bc
name: CPT1B
is encoded by: hsa:1375
constant: false
boundary condition: true
type: Species
has only substance units: false
is: Q92523
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_7343b4e5_4f89_4176_98c6_8994349bc4dc
has only substance units: false
is encoded by: hsa:10606
name: PAICS
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
is: P22234

http://identifiers.org/biomodels.db/MODEL1310110027#_799cc2d2_629b_4947_b8e1_7bbd33267810
has part: Q7GXZ4
is encoded by: hsa:4700
is encoded by: hsa:4704
is encoded by: hsa:4709
has part: O43677
has part: Q13454
constant: false
has part: Q6IBA0
is encoded by: hsa:4719
is encoded by: hsa:4720
is encoded by: hsa:4725
is encoded by: hsa:4535
is encoded by: hsa:4729
is encoded by: hsa:4539
has part: Q16718
has part: P03897
has part: O95169
is encoded by: hsa:4695
boundary condition: true
is encoded by: hsa:4723
is encoded by: hsa:51079
has only substance units: false
has part: Q7GXZ1
has part: Q549M5
has part: F8VQS7
has part: O95299
has part: P56181
is encoded by: hsa:4714
type: Species
is encoded by: hsa:4718
is encoded by: hsa:7991
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
has part: O00483
has part: P28331
has part: B7Z792
has part: Q6IBB5
has part: O95139
has part: P56556
is encoded by: hsa:4712
is encoded by: hsa:4716
is encoded by: hsa:4540
is encoded by: hsa:4722
is encoded by: hsa:4708
has part: O75251
has part: Q6IBC4
is encoded by: hsa:4697
is encoded by: hsa:4694
has part: Q6IB80
has part: P19404
initial amount: NaN
has part: C9JT23
is encoded by: hsa:4724
is encoded by: hsa:4728
is encoded by: hsa:4538
has part: Q9P0J0
has part: Q9Y6M9
has part: P03905
is encoded by: hsa:4701
has part: O43678
is encoded by: hsa:4713
is encoded by: hsa:4705
is encoded by: hsa:4717
has part: O43181
has part: O75489
has part: B1AM93
is encoded by: hsa:4711
has part: Q7GXY9
has part: E5KNH5
is: SBO:0000297
is encoded by: hsa:4715
is encoded by: hsa:4707
has part: Q6FG42
is encoded by: hsa:126328
has part: P17568
initial concentration: NaN
has part: O95167
is encoded by: hsa:4696
has part: O95168
has part: O14561
is encoded by: hsa:4731

metaR GLYPHEPEPT1tc
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Glycylphenylalanine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaM trdox c
name: Oxidized thioredoxin
is: CHEBI:18191
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: C00343

metaR GLCtg
modifier: MODEL1310110027#
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (6513.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15384581 NOTES:NCD
kinetic law: MODEL1310110027#
type: Reaction
name: glucose transport, Golgi apparatus
reactant: MODEL1310110027#
reversible: true
is: SBO:0000185
is described by: ECO:0000269
fast: false

metaR r1921
name: Y+LAT2 Utilized transport
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: false
modifier: MODEL1310110027#
fast: false
reactant: MODEL1310110027#
is: SBO:0000185
kinetic law: MODEL1310110027#
is described by: ECO:0000000

metaR CYANt
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110027#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM
name: Cyanide transport via diffusion (extracellular to cytosol)
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110027#_b204fdb1_196f_4a6f_95e6_fcffd4f282f9
boundary condition: true
constant: false
is: SBO:0000252
name: _H53099_1_m
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:H53099
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_3ecc282b_2828_4dd8_9bfa_323e583863c6
boundary condition: true
is: C9JC79
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
name: SCP2
has only substance units: false
is encoded by: hsa:6342
type: Species

metaM Rtotal2 c
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: C00055
notes: FORMULA: CO2FULLR2 CHARGE: -1
type: Species
boundary condition: false
is: HMDB00095
is: CHEBI:60377
constant: false
has only substance units: false
name: R total 2 position

http://identifiers.org/biomodels.db/MODEL1310110027#_591ff8f6_29f9_497c_ad67_aa8dfda8c3ae
initial amount: NaN
name: SLC25A1
is encoded by: hsa:6576
constant: false
is: D9HTE9
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR G14Tg
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.1) or (8703.1) or (8704.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:9597550 NOTES:NCD
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.4.1.38
reversible: false
product: MODEL1310110027#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
modifier: MODEL1310110027#

metaR TDCHOLAte
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110027#
reactant: MODEL1310110027#
name: bile acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reversible: true
kinetic law: MODEL1310110027#

metaM dcholcoa c
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
type: Species
name: chenodeoxycholoyl coenzyme a
is: SBO:0000247
boundary condition: false
is: HMDB06292
initial concentration: 1.0
initial amount: NaN
is: CHEBI:28701
constant: false
has only substance units: false

metaM h2o l
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:15377
boundary condition: false
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: HMDB02111
is: SBO:0000247
name: water

metaR RDH2
is version of: http://identifiers.org/ec-code/1.1.1.315
name: retinol dehydrogenase (9-cis,NADH)
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368,PMID:9115228 NOTES:IT
reactant: MODEL1310110027#
is described by: ECO:0000269
reversible: true
is: SBO:0000176
modifier: MODEL1310110027#
fast: false
kinetic law: MODEL1310110027#
product: MODEL1310110027#
type: Reaction

metaR CITtbm
fast: false
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
product: MODEL1310110027#
reversible: true
name: citrate transport, mitochondrial
reactant: MODEL1310110027#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with PEP IF

metaM HC00319 m
is: CHEBI:30794
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
boundary condition: false
type: Species
name: Malonate
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_acdb2c2d_2e55_4edf_9ca7_9439e8e4e8a9
type: Species
initial concentration: NaN
name: RDH16
has only substance units: false
boundary condition: true
is: O75452
is: SBO:0000252
is encoded by: hsa:8608
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_ea4e41e3_63dc_40b8_b1c7_132399b10f62
is encoded by: hsa:26266
is: Q9UKG4
boundary condition: true
initial amount: NaN
name: SLC13A4
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_a100f480_df3f_4e49_b1cc_785a1317f74d
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:4830
initial amount: NaN
constant: false
type: Species
name: NME1:NME2

metaR PUNP4
product: MODEL1310110027#
fast: false
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.4.2.1
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110027#
is: SBO:0000176
name: purine-nucleoside phosphorylase (Deoxyguanosine)
reversible: true
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
modifier: MODEL1310110027#

metaM camp c
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB00058
initial amount: NaN
is: CHEBI:58165
boundary condition: false
type: Species
notes: FORMULA: C10H11N5O6P CHARGE: -1 INCHI: InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/p-1/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00434 EHMN_ABBREVIATION: C00575
name: 3',5'-cyclic AMP(1-)
initial concentration: 1.0

metaM hdca r
has only substance units: false
is: CHEBI:7896
constant: false
is: C00249
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
is: HMDB00220
name: Hexadecanoate (n-C16:0)

metaR GGT6
fast: false
name: Gamma-glutamyltransferase
kinetic law: MODEL1310110027#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
product: MODEL1310110027#
reversible: true
reactant: MODEL1310110027#
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_9af8f669_2277_42c1_b1dd_d8e8b33f20d1
boundary condition: true
name: ADCY6
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:112
is: SBO:0000252

metaR RE3565C
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is described by: ECO:0000000
reversible: true
fast: false
name: RE3565
product: MODEL1310110027#
type: Reaction
is: SBO:0000176

metaM dgmp c
boundary condition: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
constant: false
is: CHEBI:57673
initial concentration: 1.0
is: C00362
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB01044
name: dGMP

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

metaR r1670
kinetic law: MODEL1310110027#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110027#
reversible: true
is: SBO:0000185
fast: false
reactant: MODEL1310110027#
product: MODEL1310110027#

metaR r0295
is described by: ECO:0000000
modifier: MODEL1310110027#
fast: false
reactant: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
product: MODEL1310110027#
name: glycine synthase Nitrogen metabolism EC:2.1.2.10

metaR XYLUR
name: xylulose reductase
product: MODEL1310110027#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51181.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.10 Confidence Level: 4 AUTHORS: PMID:11882650,PMID:6821187 NOTES:
type: Reaction
reactant: MODEL1310110027#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.10
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110027#_102c25f5_ea88_4eae_a413_bee259cd4603
type: Species
constant: false
name: ST3GAL3
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6487
has only substance units: false
is: SBO:0000252
is: B4DX62

http://identifiers.org/biomodels.db/MODEL1310110027#_a7510436_bb95_4ac5_9fe1_f7f77c7034d7
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: DGKB
type: Species
is encoded by: hsa:1607
has only substance units: false
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110027#_98c0a3fb_cec6_42d6_9903_c8e33283f699
constant: false
initial concentration: NaN
is encoded by: hsa:2530
has only substance units: false
is: Q546E0
is: SBO:0000252
initial amount: NaN
type: Species
name: FUT8
boundary condition: true

metaM ksi pre9 g
is: C00130
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C121H196N8O93S2X CHARGE: -3
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 9
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:58053
is: HMDB00175
constant: false

metaR PYRt2r
is: SBO:0000185
fast: false
reversible: true
product: MODEL1310110027#
kinetic law: MODEL1310110027#
is described by: ECO:0000269
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
modifier: MODEL1310110027#
name: pyruvate reversible transport via proton symport
type: Reaction

metaR RDH3
fast: false
reactant: MODEL1310110027#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110027#
product: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368 NOTES:IT
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.315
name: retinol dehydrogenase (11-cis,NADH)
modifier: MODEL1310110027#

metaM dag hs n
is: CHEBI:18035
is: SBO:0000247
name: diglyceride
boundary condition: false
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false

metaM orot e
is: CHEBI:30839
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
is: HMDB00226
type: Species
boundary condition: false
is: SBO:0000247
name: orotate
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295

metaM ethamp c
initial concentration: 1.0
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
initial amount: NaN
has only substance units: false
is: CHEBI:58190
name: ethamp[c]
is: SBO:0000247
is: HMDB00224
boundary condition: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_93c00ece_4d29_4212_9992_12c3587e8a8f
initial amount: NaN
is encoded by: hsa:5831
is: P32322
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: PYCR1
type: Species
constant: false
boundary condition: true

metaR r1819
fast: false
name: Y+LAT2 Utilized transport
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110027#
is described by: ECO:0000000
product: MODEL1310110027#
type: Reaction
reversible: false
kinetic law: MODEL1310110027#

metaR PUNP3
reversible: true
is described by: ECO:0000269
product: MODEL1310110027#
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.4.2.1
type: Reaction
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
modifier: MODEL1310110027#
reactant: MODEL1310110027#
fast: false
is: SBO:0000176
name: purine-nucleoside phosphorylase (Guanosine)

metaR LNLCCRNt
name: transport into the mitochondria (carnitine)
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000185
type: Reaction
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reversible: false
is described by: ECO:0000269
fast: false
modifier: MODEL1310110027#

metaR ACt2m
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD
name: acetate mitochondrial transport via proton symport
is: SBO:0000185
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
product: MODEL1310110027#
fast: false
reversible: true
is described by: ECO:0000000

metaM sbt D c
constant: false
type: Species
is: CHEBI:17924
has only substance units: false
initial amount: NaN
is: HMDB00247
initial concentration: 1.0
name: D-glucitol
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110027#_9c01fdbd_c9d2_4b0b_834a_dae6776ac811
is encoded by: hsa:1798
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
constant: false
name: DPAGT1
is: Q9H3H5
initial concentration: NaN
initial amount: NaN

metaR r2320
kinetic law: MODEL1310110027#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
product: MODEL1310110027#
fast: false
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
is described by: ECO:0000000

metaM ksi pre14 g
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C143H230N10O114S4X CHARGE: -5
initial concentration: 1.0
constant: false
is: CHEBI:28067
type: Species
name: keratan sulfate I biosynthesis, precursor 14

metaM dectricoa m
constant: false
name: 2,4,7-decatrienoylcoa
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C31H44N7O17P3S CHARGE: -4
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_435c1443_578a_4b3f_afb9_cf5c3710e7f7
is encoded by: hsa:641372
name: ACOT6
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is: Q3I5F7

metaR TXASr
kinetic law: MODEL1310110027#
type: Reaction
is version of: http://identifiers.org/ec-code/5.3.99.5
reactant: MODEL1310110027#
is described by: ECO:0000134
modifier: MODEL1310110027#
product: MODEL1310110027#
name: Thromboxane-A synthase
notes: GENE_ASSOCIATION: (6916.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.5 Confidence Level: 0 AUTHORS: PMID:10903770,PMID:2491846,PMID:7811713 NOTES:NJ
reversible: false
is: SBO:0000176
fast: false

metaR r1671
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110027#
product: MODEL1310110027#
is: SBO:0000185
name: Y+LAT2 Utilized transport
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
fast: false

metaM h2o n
is: HMDB02111
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:15377
name: water

metaM HC01231 m
boundary condition: false
initial amount: NaN
name: N-[(R)-pantothenoyl]-L-cysteinate
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:58480
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079

metaR SARDHm
reactant: MODEL1310110027#
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.99.1
kinetic law: MODEL1310110027#
reversible: false
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (1757.1) SUBSYSTEM: Urea cycle EC Number: 1.5.99.2 Confidence Level: 4 AUTHORS: PMID:10444331 NOTES:SAB EC # is questionable overall reaction is questionable
fast: false
modifier: MODEL1310110027#
is described by: ECO:0000269
is: SBO:0000176
name: Sarcosine dehydrogenase (m)

http://identifiers.org/biomodels.db/MODEL1310110027#_f5bb2da7_00ff_4d63_ac1d_30a9101fe55f
name: UCP3
has only substance units: false
type: Species
constant: false
boundary condition: true
is: P55916
initial amount: NaN
is encoded by: hsa:7352
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110027#_b9d5c5ad_1547_4b21_b13f_2b277246fadd
has only substance units: false
boundary condition: true
type: Species
name: UPB1
initial amount: NaN
is: SBO:0000252
is: B3KNC1
initial concentration: NaN
constant: false
is encoded by: hsa:51733

metaR r2321
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110027#
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
reactant: MODEL1310110027#

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

metaR PI45P5P
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
modifier: MODEL1310110027#
reactant: MODEL1310110027#
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
kinetic law: MODEL1310110027#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.36
type: Reaction
product: MODEL1310110027#
is described by: ECO:0000000
fast: false
reversible: false

metaM dc2coa m
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:61406
name: trans-Dec-2-enoyl-CoA
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275
is: SBO:0000247

metaM dgmp e
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
is: SBO:0000247
name: dGMP(2-)
type: Species
is: HMDB01044
has only substance units: false
is: CHEBI:57673
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false

metaM 2hexdtetcoa m
initial concentration: 1.0
name: 2,7,10,13-hexadecatetraenoylcoa
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
is: HMDB02288
type: Species
initial amount: NaN
notes: FORMULA: C37H54N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110027#_282ce096_eae6_4246_a832_a8c139308662
constant: false
is: SBO:0000252
is: O95169
boundary condition: true
name: NDUFB8
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4714
type: Species
has only substance units: false

metaR RDH1
name: retinol dehydrogenase (all-trans)
is version of: http://identifiers.org/ec-code/1.1.1.315
modifier: MODEL1310110027#
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
is: SBO:0000176
is described by: ECO:0000269
reversible: true
fast: false
type: Reaction
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES:IT

metaM h2o m
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: H2O
is: C00001
constant: false
is: CHEBI:15377
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: HMDB02111
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110027#_87a0a92b_f95c_44b5_b67d_d7a76746bca7
name: SLC25A11
boundary condition: true
initial amount: NaN
is: F5GY65
type: Species
constant: false
has only substance units: false
is encoded by: hsa:8402
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110027#_a4fe4d76_fdeb_4f08_bd32_a470da57e8fc
type: Species
has only substance units: false
initial concentration: NaN
is: P54868
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
name: HMGCS2
is encoded by: hsa:3158

http://identifiers.org/biomodels.db/MODEL1310110027#_5b4d02f6_7487_4270_868b_d44914d692d5
boundary condition: true
has only substance units: false
type: Species
name: HMGCS1
is encoded by: hsa:3157
constant: false
initial amount: NaN
is: SBO:0000252
is: Q01581
initial concentration: NaN

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

metaM mescon m
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
name: Mesaconate
constant: false
is: CHEBI:36986
initial amount: NaN
is: HMDB00749

metaM prostgd2 r
boundary condition: false
has only substance units: false
is: HMDB01403
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:57406
name: prostaglandin D2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
initial amount: NaN

metaM Rtotal3coa c
initial amount: NaN
is: CHEBI:16189
boundary condition: false
has only substance units: false
name: R total 3 Coenzyme A
is: HMDB01448
constant: false
notes: FORMULA: CO2FULLR3C21H31N7O15P3S CHARGE: -4
is: SBO:0000247
type: Species
initial concentration: 1.0

metaM tcynt c
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
type: Species
constant: false
name: thiocyanate
initial concentration: 1.0
is: HMDB01453
boundary condition: false
is: CHEBI:18022
has only substance units: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_0b45df58_7967_40ae_8eb2_39c5b6fc9627
has only substance units: false
is encoded by: hsa:7108
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
is: O76062
name: TM7SF2
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_21009b4e_e9bc_4ca0_b262_e6f0d650cfb5
is encoded by: hsa:8560
is: SBO:0000252
type: Species
constant: false
name: DEGS1
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR r1527
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
fast: false
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
is: SBO:0000185
reversible: false
reactant: MODEL1310110027#
modifier: MODEL1310110027#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.1
product: MODEL1310110027#

metaM ksii core4 l
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:57255
is: SBO:0000247
type: Species
is: HMDB01014
initial concentration: 1.0
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
name: keratan sulfate II (core 4-linked)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_ba31e920_0f9b_4879_896d_ddf50bfb006d
has only substance units: false
is encoded by: hsa:6487
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
constant: false
initial concentration: NaN
name: ST3GAL3

metaR CYTK14
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
is described by: ECO:0000269
modifier: MODEL1310110027#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110027#
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110027#
name: cytidylate kinase (dCMP,UTP)
type: Reaction

metaM h2o g
type: Species
is: CHEBI:15377
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB02111
boundary condition: false
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
constant: false
name: water

metaR ACHtn
reactant: MODEL1310110027#
product: MODEL1310110027#
name: Acetylcholin transport, nuclear trhough pores
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
fast: false
is: SBO:0000185
reversible: true

metaR EX 10fthf6glu LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](6) exchange
type: Reaction

metaM ksii core2 pre1 g
boundary condition: false
notes: FORMULA: C33H53N3O23X CHARGE: -1
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:28067
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 1
initial amount: NaN
is: SBO:0000247

metaM leuktrC4 c
is: SBO:0000247
boundary condition: false
is: CHEBI:57973
name: leukotriene C4(2-)
initial concentration: 1.0
constant: false
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
is: HMDB01198
has only substance units: false
initial amount: NaN
type: Species

metaR ACACT5p
fast: false
product: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
is: SBO:0000176
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.16
name: acetyl-CoA C-acyltransferase (decanoyl-CoA), peroxisomal
type: Reaction
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_49e4515e_d0a1_4470_9af3_4912493c80b0
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
is: Q9BZ23
is encoded by: hsa:80025
boundary condition: true
name: PANK2
type: Species

metaR GPIAT
product: MODEL1310110027#
is described by: ECO:0000269
kinetic law: MODEL1310110027#
fast: false
type: Reaction
reactant: MODEL1310110027#
modifier: MODEL1310110027#
reversible: false
name: glucosaminylphosphatidyl inositol acetyltransferase
is: SBO:0000176
notes: GENE_ASSOCIATION: (284098.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14517336 NOTES:EC 2.3.-.- NCD

http://identifiers.org/biomodels.db/MODEL1310110027#_a95efd24_09ba_4ee2_9038_2cb895236595
is encoded by: hsa:10637
is: SBO:0000252
boundary condition: true
type: Species
is: O75610
has only substance units: false
name: LEFTY1
constant: false
initial amount: NaN
initial concentration: NaN

metaM ppcoa c
initial amount: NaN
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
initial concentration: 1.0
boundary condition: false
is: C00100
is: CHEBI:57392
name: Propanoyl-CoA
is: SBO:0000247
is: HMDB01275
constant: false
has only substance units: false
type: Species

metaR SMPD3g
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.12
modifier: MODEL1310110027#
product: MODEL1310110027#
reversible: false
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (55512.1) or (55512.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110027#
name: sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
type: Reaction
reactant: MODEL1310110027#
fast: false

metaR r2100
kinetic law: MODEL1310110027#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110027#
product: MODEL1310110027#
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110027#

metaR C10DCCACT
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacoyl carnitine into cytosol
type: Reaction

metaR PI34P5K
type: Reaction
reactant: MODEL1310110027#
is: SBO:0000176
fast: false
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
kinetic law: MODEL1310110027#
reversible: false
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.1.68
modifier: MODEL1310110027#
is described by: ECO:0000000

metaR r2195
fast: false
modifier: MODEL1310110027#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110027#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110027#
is described by: ECO:0000000
reversible: true
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR S6T1g
fast: false
modifier: MODEL1310110027#
reversible: false
is: SBO:0000176
product: MODEL1310110027#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110027#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110027#
type: Reaction

metaR ADSS
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/6.3.4.4
name: adenylosuccinate synthase
type: Reaction
is: SBO:0000176
fast: false
product: MODEL1310110027#
reversible: false
modifier: MODEL1310110027#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
reactant: MODEL1310110027#

metaM ser D e
is: CHEBI:16523
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
is: HMDB03406
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
name: D-serine
boundary condition: false
type: Species
has only substance units: false

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

metaR CYTK13
is described by: ECO:0000269
kinetic law: MODEL1310110027#
is: SBO:0000176
reversible: true
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP,dATP)
reactant: MODEL1310110027#
modifier: MODEL1310110027#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR LEUPHELAT2tc
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaR TRDR
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.8.1.9
type: Reaction
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
fast: false
is: SBO:0000176
product: MODEL1310110027#
reactant: MODEL1310110027#
reversible: false
name: thioredoxin reductase (NADPH)
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:

metaR GLCURter
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
name: glucuronate endoplasmic reticular transport
reactant: MODEL1310110027#
product: MODEL1310110027#
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: false

metaM ps hs m
name: ps_hs[m]
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:18303

http://identifiers.org/biomodels.db/MODEL1310110027#_fee73164_b8ae_478e_9310_8accae6e6789
is: SBO:0000252
is encoded by: hsa:4535
boundary condition: true
has only substance units: false
initial amount: NaN
name: ND1
initial concentration: NaN
constant: false
type: Species
is: Q85KV6

http://identifiers.org/biomodels.db/MODEL1310110027#_432a3ee4_60cb_4bc2_be8e_2d17cf35ff25
name: SLC22A2
initial concentration: NaN
is encoded by: hsa:6582
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_dcbafa59_5437_4d3f_982b_eb20806c108d
is: H7C5B8
is encoded by: hsa:4708
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
name: NDUFB2

metaR PUNP7
fast: false
product: MODEL1310110027#
is described by: ECO:0000269
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.1
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
reversible: true
is: SBO:0000176
name: purine-nucleoside phosphorylase (Xanthosine)

metaM sbt D e
boundary condition: false
initial amount: NaN
has only substance units: false
name: D-glucitol
initial concentration: 1.0
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
constant: false
is: HMDB00247
is: SBO:0000247
type: Species

metaM retinal c
type: Species
is: HMDB01358
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
is: SBO:0000247
name: retinal
is: CHEBI:15035
initial concentration: 1.0

metaR r2101
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110027#
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
fast: false
type: Reaction
is: SBO:0000185
reversible: true

metaR MG1er
kinetic law: MODEL1310110027#
type: Reaction
product: MODEL1310110027#
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
is version of: http://identifiers.org/ec-code/3.2.1.106
modifier: MODEL1310110027#
is: SBO:0000176
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (7841.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.106 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110027#_257a888a_5543_4dc8_8d6c_61bf13bca22a
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: NDUFB5
is: O43674
is encoded by: hsa:4711
is: SBO:0000252
type: Species
constant: false
boundary condition: true

metaM hxan c
constant: false
is: HMDB00157
is: C00262
has only substance units: false
boundary condition: false
name: Hypoxanthine
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:17368
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
initial amount: NaN

metaR UDPGLCAter
fast: false
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
modifier: MODEL1310110027#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110027#
type: Reaction
product: MODEL1310110027#
is described by: ECO:0000269
name: UDPGlcA endoplasmic reticulum transport via UMP antiport

metaR ASNPHELAT2tc
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Asparagine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaR GULNter
kinetic law: MODEL1310110027#
name: L-gulonate endoplasmic reticular export
is described by: ECO:0000000
reactant: MODEL1310110027#
type: Reaction
is: SBO:0000185
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
reversible: false

metaM ksi pre24 g
notes: FORMULA: C191H306N13O158S7X CHARGE: -8
is: SBO:0000247
constant: false
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 24
is: C00130
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
is: HMDB00175
is: CHEBI:58053

metaR RE2626M
fast: false
modifier: MODEL1310110027#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
name: RE2626
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
product: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.14.13.15

metaM dag hs r
is: SBO:0000247
constant: false
name: diglyceride
initial amount: NaN
is: CHEBI:18035
initial concentration: 1.0
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
type: Species
has only substance units: false
boundary condition: false

metaR ACGAMtly
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: N-acetyl-glucosamine lysosomal efflux
kinetic law: MODEL1310110027#
reversible: false
reactant: MODEL1310110027#
fast: false
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD

metaR r0774
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110027#
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110027#
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110027#_a7541549_e833_4aa8_8d47_7a0509dab357
is encoded by: hsa:33
name: ACADL
initial concentration: NaN
is: P28330
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
type: Species

metaR NCAMUP
product: MODEL1310110027#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069599,PMID:1463467 NOTES:SAB mechanism copied from nac--not certain
reversible: false
reactant: MODEL1310110027#
fast: false
name: Nicotinamide acid uptake
kinetic law: MODEL1310110027#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_11623dd1_dc72_4c25_90df_b550e207491e
initial concentration: NaN
is: P15531
is encoded by: hsa:4830
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
name: NME1
type: Species

metaM fru c
is: HMDB00660
is: CHEBI:15824
has only substance units: false
constant: false
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
is: C00095
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: D-Fructose

metaM Rtotal2 e
boundary condition: false
has only substance units: false
is: CHEBI:3554
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
name: R total 2 position
notes: FORMULA: CO2FULLR2 CHARGE: -1
is: HMDB00244
is: C00255

http://identifiers.org/biomodels.db/MODEL1310110027#_2996815a_0a73_4e06_a542_decdf97f3ab4
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:8277
name: TKTL1
is: SBO:0000252
constant: false
initial amount: NaN
is: B7Z7I0

metaM orn m
type: Species
is: HMDB00214
notes: FORMULA: C5H13N2O2 CHARGE: 1
constant: false
is: CHEBI:46912
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
name: Ornithine
initial concentration: 1.0
is: C01602

http://identifiers.org/biomodels.db/MODEL1310110027#_a3bd0af7_e67e_4706_abbc_9fa127f833a3
is: O00483
is: SBO:0000252
is encoded by: hsa:4697
initial amount: NaN
name: NDUFA4
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false

metaR r2102
product: MODEL1310110027#
modifier: MODEL1310110027#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reversible: true
reactant: MODEL1310110027#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110027#_9065b5b9_53ee_4b27_8e61_0d610a4713ba
is: SBO:0000252
type: Species
name: _AA629629_1_m
is encoded by: hsa:AA629629
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false

metaR FAOXC226C227m
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:7)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_37764d47_e038_4fce_bf6b_b065d5f247d6
initial amount: NaN
name: ND4
initial concentration: NaN
is: P03905
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:4538
constant: false

metaR ACONTm
product: MODEL1310110027#
is described by: ECO:0000134
name: Aconitate hydratase
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical
type: Reaction
reversible: true
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/4.2.1.3
fast: false
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
is: SBO:0000176

metaR PI345P5P
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.1.3.86
notes: GENE_ASSOCIATION: (3633.1) or (27124.1) or (3635.1) or (3636.1) or (8871.1) or (56623.1) or (8867.2) or (27124.2) or (8867.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.56
is version of: http://identifiers.org/ec-code/3.1.3.36
product: MODEL1310110027#
kinetic law: MODEL1310110027#
name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
modifier: MODEL1310110027#
is: SBO:0000176

metaR RE0944E
is version of: http://identifiers.org/ec-code/3.2.1.1
name: RE0944
modifier: MODEL1310110027#
product: MODEL1310110027#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110027#
fast: false
reactant: MODEL1310110027#
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.17
type: Reaction
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110027#_c095eed7_c481_4285_a16e_cc8813ae6237
type: Species
is encoded by: hsa:55229
constant: false
has only substance units: false
is: Q9NVE7
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: PANK4

metaR r2193
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110027#
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110027#
is described by: ECO:0000000
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110027#

metaR RE3627M
product: MODEL1310110027#
name: RE3627
type: Reaction
is: SBO:0000176
modifier: MODEL1310110027#
reversible: true
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
is described by: ECO:0000000
reactant: MODEL1310110027#

metaR RDH4
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.1.1.315
is described by: ECO:0000269
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:9115228 NOTES:IT
reversible: true
is: SBO:0000176
modifier: MODEL1310110027#
fast: false
kinetic law: MODEL1310110027#
name: retinol dehydrogenase (13-cis,NADH)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_02a911a6_8652_43a5_a6c5_275affa47995
has only substance units: false
name: PIK3CA
is encoded by: hsa:5290
initial amount: NaN
is: P42336
type: Species
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN

metaR CLFORtex
notes: GENE_ASSOCIATION: (5172.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
name: chloride transport via formate countertransport
product: MODEL1310110027#
fast: false
kinetic law: MODEL1310110027#
type: Reaction
is described by: ECO:0000304
is: SBO:0000185
modifier: MODEL1310110027#
reversible: false
reactant: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_56848f59_9d4b_4cc6_b283_564abb24e895
initial amount: NaN
name: GALNT10
is encoded by: hsa:55568
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252

metaR sink pre prot LPAREN r RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycophosphatidylinositol (GPI)-anchored protein precursor sink
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_fc1abece_62cf_42dd_9234_dd351142369d
boundary condition: true
is: Q1LZ56
has only substance units: false
initial amount: NaN
is encoded by: hsa:206358
type: Species
initial concentration: NaN
name: SLC36A1
is: SBO:0000252
constant: false

metaM 13 cis retn c
name: 13-cis-retinoate
has only substance units: false
is: http://identifiers.org/pubchem.compound/7847414
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB06219
is: D00348
constant: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
initial amount: NaN
type: Species

metaM 3hexdtetcoa m
boundary condition: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
name: 3,7,10,13-hexadecatetraenoylcoa
initial amount: NaN
type: Species
is: HMDB02288

metaR CYTK11
is described by: ECO:0000269
reversible: true
is: SBO:0000176
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
name: cytidylate kinase (dCMP,dGTP)
reactant: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#

metaR S6T9g
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110027#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110027#
reversible: false

metaR r2103
reversible: true
is described by: ECO:0000000
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110027#
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110027#
modifier: MODEL1310110027#

metaR PUNP5
modifier: MODEL1310110027#
product: MODEL1310110027#
fast: false
kinetic law: MODEL1310110027#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.1
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
type: Reaction
reversible: true
name: purine-nucleoside phosphorylase (Inosine)
reactant: MODEL1310110027#
is: SBO:0000176

metaR CERT1gt
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.11.1
reactant: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#
name: ceramide transport protein
is described by: ECO:0000304
fast: false
reversible: true
product: MODEL1310110027#
is: SBO:0000185

metaR r1817
kinetic law: MODEL1310110027#
fast: false
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110027#
modifier: MODEL1310110027#
product: MODEL1310110027#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: false

metaR AG13T15g
is described by: ECO:0000000
reactant: MODEL1310110027#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
is: SBO:0000176

metaM orot c
is: CHEBI:30839
has only substance units: false
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
is: HMDB00226
boundary condition: false
initial amount: NaN
constant: false
name: Orotate
is: SBO:0000247
type: Species
is: C00295
initial concentration: 1.0

metaM asp L c
initial amount: NaN
has only substance units: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
is: HMDB00191
name: L-aspartate(1-)
type: Species
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:29991
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110027#_e5d336e1_eb87_46c6_aaf2_050926ca3a0e
has only substance units: false
constant: false
name: NDUFS5
is encoded by: hsa:4725
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q6IBA0
initial concentration: NaN
type: Species

metaR DOLASNT Ler
is described by: ECO:0000000
product: MODEL1310110027#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.119
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (6185.1 and 1650.1 and 6184.1 and 1603.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.119 Confidence Level: 0 AUTHORS: NOTES:NCD
name: Dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase (liver)
fast: false
reactant: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_a00a872d_e5ee_4735_9320_e7aadea8d397
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: SULT1A3
is: P50224
type: Species
is encoded by: hsa:6818

metaR MI134P4P
type: Reaction
reactant: MODEL1310110027#
fast: false
reversible: false
is described by: ECO:0000000
is: SBO:0000176
name: inositol-1,3,4-trisphosphate 4-phosphatase
kinetic law: MODEL1310110027#
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD

metaR AG13T16g
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10678.2) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
reactant: MODEL1310110027#
product: MODEL1310110027#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110027#_8d6eda7f_a745_4d21_80a9_9988292a511e
is: O95168
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4710
initial concentration: NaN
initial amount: NaN
name: NDUFB4
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110027#_b911c4ef_eaf8_4b67_8c88_19c0a4dc88ea
boundary condition: true
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: OGDHL
has only substance units: false
is: Q9ULD0
is encoded by: hsa:55753

metaR CHSTEROLt3
is described by: ECO:0000000
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110027#
product: MODEL1310110027#
name: cholesterol intracellular transport
type: Reaction
reactant: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

metaM fru e
boundary condition: false
is: CHEBI:15824
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: C00095
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
type: Species
is: HMDB00660
initial concentration: 1.0
name: D-Fructose

http://identifiers.org/biomodels.db/MODEL1310110027#_3e2e8533_db13_403c_89bd_a4a2207f1283
constant: false
name: NT5C2
is: P49902
initial concentration: NaN
has only substance units: false
is encoded by: hsa:22978
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110027#_f171947f_4227_4974_967d_3ace21b6659e
is: B2RBR4
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
name: SLC20A2
is encoded by: hsa:6575

metaR r2105
reactant: MODEL1310110027#
is: SBO:0000185
is described by: ECO:0000000
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
product: MODEL1310110027#
type: Reaction
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#

metaR PSFLIPm
modifier: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ
product: MODEL1310110027#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.3.1
kinetic law: MODEL1310110027#
is: SBO:0000185
fast: false
type: Reaction
name: phosphatidylserine flippase
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110027#_9ae16474_9a69_4537_aff2_a326b8f10d6f
boundary condition: true
is encoded by: hsa:123041
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
name: SLC24A4

metaR URAt
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
product: MODEL1310110027#
name: uracil transport via facilated diffusion
is: SBO:0000185
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
fast: false
reversible: true
is described by: ECO:0000269

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

metaM ump g
name: UMP(2-)
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57865
type: Species
is: HMDB00288
has only substance units: false
boundary condition: false

metaR GLUPRT
kinetic law: MODEL1310110027#
is described by: ECO:0000269
modifier: MODEL1310110027#
type: Reaction
product: MODEL1310110027#
name: glutamine phosphoribosyldiphosphate amidotransferase
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.14
reactant: MODEL1310110027#

metaR r2327
reactant: MODEL1310110027#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110027#
is: SBO:0000185

metaR PPA
is version of: http://identifiers.org/ec-code/3.6.1.1
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:
is: SBO:0000176
name: inorganic diphosphatase
modifier: MODEL1310110027#
fast: false
is described by: ECO:0000269
type: Reaction
reversible: false
product: MODEL1310110027#
reactant: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_c1113a71_e2cb_480a_841e_9a116e4e50d6
initial amount: NaN
is: P48751
initial concentration: NaN
name: SLC4A3
type: Species
has only substance units: false
constant: false
is encoded by: hsa:6508
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110027#_2bf9b05f_45b0_4df8_bbac_bdd88df53bcd
has only substance units: false
type: Species
boundary condition: true
constant: false
is: SBO:0000252
is: Q8TD20
is encoded by: hsa:154091
initial concentration: NaN
name: SLC2A12
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_b2ad5e68_6056_4cfa_890b_0087ee2d96a0
has only substance units: false
constant: false
name: ACP5
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:54
initial amount: NaN
is: P13686
boundary condition: true

metaR DOLGPP Ler
reversible: false
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.4.48 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
name: Dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase (liver)

metaR HSD3B12r
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
fast: false
type: Reaction
modifier: MODEL1310110027#
name: 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I
is described by: ECO:0000134
reversible: false
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (3284.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12832414 NOTES:kinetic studies done with recombinant human cDNA transfected into baculovirus
is version of: http://identifiers.org/ec-code/1.1.1.145
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110027#_93936f24_a497_4b29_95c7_18f61fe40341
constant: false
type: Species
is encoded by: hsa:AA664770
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: _AA664770_1_m
has only substance units: false
is: SBO:0000252

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

metaR r2104
is described by: ECO:0000000
fast: false
is: SBO:0000185
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
reversible: true
type: Reaction
product: MODEL1310110027#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR EX nac LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinate exchange
type: Reaction

metaM ksi pre34 g
is: SBO:0000247
notes: FORMULA: C241H385N17O202S10X CHARGE: -11
name: keratan sulfate I biosynthesis, precursor 34
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:58053
is: HMDB00175
is: C00130
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_b5753090_e5f3_44aa_a300_770f904919fb
boundary condition: true
is encoded by: hsa:57379
initial concentration: NaN
constant: false
is: Q546Y9
is: SBO:0000252
name: AICDA
type: Species
initial amount: NaN
has only substance units: false

metaM ksii core4 deg3 l
is: HMDB00143
name: keratan sulfate II (core 4-linked), degradation product 3
boundary condition: false
is: CHEBI:12936
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C66H107N6O51S2X CHARGE: -2
type: Species
has only substance units: false
initial amount: NaN

metaM hdd2coa c
initial amount: NaN
boundary condition: false
is: C05272
is: CHEBI:61526
constant: false
is: SBO:0000247
is: HMDB03945
name: trans-Hexadec-2-enoyl-CoA
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
initial concentration: 1.0
has only substance units: false
type: Species

metaM o2 m
is: SBO:0000247
boundary condition: false
name: O2
initial concentration: 1.0
is: C00007
is: HMDB01377
is: CHEBI:15379
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
type: Species
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_a2aaf188_430a_4b16_a7d3_c723b538dd52
boundary condition: true
type: Species
is: Q9Y217
initial amount: NaN
name: MTMR6
is encoded by: hsa:9107
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false

metaM CE2433 m
constant: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
is: CHEBI:57795
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species

metaR r0330
fast: false
reactant: MODEL1310110027#
name: 5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
product: MODEL1310110027#
reversible: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500,PMID:8615641 NOTES:
is described by: ECO:0000000

metaM thp2c x
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
type: Species
is: SBO:0000247
name: 1-piperideine-6-carboxylate
is: HMDB12130
initial amount: NaN
boundary condition: false
is: CHEBI:16987

http://identifiers.org/biomodels.db/MODEL1310110027#_c77def95_d479_404c_a90a_452b2c9bcc73
is encoded by: hsa:4696
is: O95167
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
name: NDUFA3
type: Species
initial amount: NaN
is: SBO:0000252

metaR r0670
reactant: MODEL1310110027#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
name: (S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
is described by: ECO:0000000
product: MODEL1310110027#
fast: false
type: Reaction
kinetic law: MODEL1310110027#

metaR PE HStm
is: SBO:0000185
type: Reaction
reactant: MODEL1310110027#
name: phosphatidylethanolamine scramblase
fast: false
kinetic law: MODEL1310110027#
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
reversible: true

metaR r2326
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110027#
fast: false
product: MODEL1310110027#
reactant: MODEL1310110027#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000

metaM ump e
is: CHEBI:57865
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
name: UMP(2-)
initial amount: NaN
boundary condition: false
is: HMDB00288
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105

http://identifiers.org/biomodels.db/MODEL1310110027#_18bf6957_a462_4a7f_834a_6c4498362a34
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:85365
is: SBO:0000252
name: ALG2
boundary condition: true

metaR r2329
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
type: Reaction
product: MODEL1310110027#
fast: false
is described by: ECO:0000000

metaR r2107
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reversible: true
product: MODEL1310110027#
reactant: MODEL1310110027#
is: SBO:0000185
is described by: ECO:0000000

metaM dhf c
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
type: Species
is: SBO:0000247
is: HMDB01056
initial concentration: 1.0
has only substance units: false
is: C00415
name: 7,8-Dihydrofolate
boundary condition: false
is: CHEBI:57451
constant: false
initial amount: NaN

metaM so4 l
name: sulfate
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB01448
constant: false
is: CHEBI:16189
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059

metaM didp n
is: CHEBI:28823
is: HMDB03536
name: dIDP
type: Species
has only substance units: false
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaM o2s m
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: SBO:0000247
is: C00704
is: CHEBI:18421
name: Superoxide anion
constant: false
is: HMDB02168

metaR RE1233C
reactant: MODEL1310110027#
is: SBO:0000176
fast: false
name: RE1233
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
product: MODEL1310110027#
kinetic law: MODEL1310110027#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.6.1.64
modifier: MODEL1310110027#

metaM gpi sig r
has only substance units: false
is: HMDB00224
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58190
constant: false
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: Y CHARGE: 0
name: glycophosphatidylinositol (GPI) signal sequence (C-terminal peptide)

metaM met L c
boundary condition: false
name: L-methionine
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
initial concentration: 1.0
has only substance units: false
is: CHEBI:16643
is: HMDB00696

http://identifiers.org/biomodels.db/MODEL1310110027#_fcb97142_cc24_4cc9_ba95_aec82b127853
is: SBO:0000252
initial concentration: NaN
name: FASN
has only substance units: false
boundary condition: true
is: P49327
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:2194

http://identifiers.org/biomodels.db/MODEL1310110027#_76bc9147_b61b_454a_a44c_9e242bbd43f2
initial amount: NaN
is encoded by: hsa:221823
is: SBO:0000252
name: PRPS1L1
is: P21108
boundary condition: true
type: Species
constant: false
initial concentration: NaN
has only substance units: false

metaM ser D c
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: D-serine
is: CHEBI:16523
is: SBO:0000247
constant: false
is: HMDB03406

metaM HC00319 c
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:30794
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
initial concentration: 1.0
type: Species
name: Malonate

http://identifiers.org/biomodels.db/MODEL1310110027#_bc312664_9dbb_4272_9995_465f9ae6fd89
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AF080579
constant: false
name: _AF080579_1_c
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_380c9b5d_365d_4bda_8138_70a4b0ce347d
is encoded by: hsa:8818
is encoded by: hsa:54344
initial amount: NaN
name: DPM3:DPM1:DPM2
has only substance units: false
type: Species
has part: Q9P2X0
initial concentration: NaN
boundary condition: true
is: SBO:0000297
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_561a26bf_1b40_4638_9395_ced3905d55bd
boundary condition: true
name: SLC5A2
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: P31639
is encoded by: hsa:6524

metaM uacgam c
is: HMDB00290
boundary condition: false
is: SBO:0000247
type: Species
constant: false
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
has only substance units: false
is: CHEBI:57705
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043

metaR r2106
modifier: MODEL1310110027#
is: SBO:0000185
reversible: true
product: MODEL1310110027#
fast: false
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
is described by: ECO:0000000

metaM glu5sa m
is: CHEBI:17232
initial concentration: 1.0
type: Species
name: L-Glutamate 5-semialdehyde
boundary condition: false
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
initial amount: NaN
constant: false
is: SBO:0000247
is: C01165
is: HMDB02104
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_2eeda817_3fd6_4f81_8695_2571b00dcdca
type: Species
has only substance units: false
name: KL
is: SBO:0000252
is encoded by: hsa:9365
is: Q9UEF7
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_7f91fc1b_360a_4760_bed6_a5ff770bc70e
has only substance units: false
is: Q9Y6L6
is: SBO:0000252
initial concentration: NaN
constant: false
name: SLCO1B1
is encoded by: hsa:10599
type: Species
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_35262cd9_124e_47b1_863b_8286c7fa6b68
is: Q9NRF8
initial amount: NaN
type: Species
name: CTPS2
boundary condition: true
is encoded by: hsa:56474
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN

metaR r1453
product: MODEL1310110027#
kinetic law: MODEL1310110027#
reversible: true
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110027#
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110027#_6530a58f_41ed_4b9f_871a_b93cfec24956
is: P08842
name: STS
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:412
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
constant: false

metaM hx2coa m
has only substance units: false
type: Species
is: HMDB02288
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
name: trans-Hex-2-enoyl-CoA

metaM fad r
type: Species
is: HMDB01248
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:16238
name: Flavin adenine dinucleotide oxidized
initial amount: NaN
has only substance units: false
constant: false

metaR r2328
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110027#
is described by: ECO:0000000
kinetic law: MODEL1310110027#
type: Reaction
product: MODEL1310110027#

metaR ARACHDtr
fast: false
reversible: true
product: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
reactant: MODEL1310110027#
name: intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110027#_daab6d2b_fd9d_4d33_9f83_bd7972ca42c9
has only substance units: false
constant: false
name: GGH
is: Q92820
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:8836
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_8ff491bd_e9f0_43e6_b846_5128c04feee1
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:26279
name: PLA2G2D
is: SBO:0000252
type: Species
is: Q9UNK4

http://identifiers.org/biomodels.db/MODEL1310110027#_17d84542_5af2_4186_b166_efc03cccb709
name: SLC9A3
is encoded by: hsa:6550
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
is: P48764
initial amount: NaN
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_62b6f7c6_5650_495e_b3af_c794ef2ca9c8
initial concentration: NaN
constant: false
has only substance units: false
is: Q13615
type: Species
initial amount: NaN
is: SBO:0000252
name: MTMR3
boundary condition: true
is encoded by: hsa:8897

metaM 2mpdhl m
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C12H23NO2S2 CHARGE: 0 INCHI: InChI=1S/C12H23NO2S2/c1-9(2)12(15)17-8-7-10(16)5-3-4-6-11(13)14/h9-10,16H,3-8H2,1-2H3,(H2,13,14) EHMN_ABBREVIATION: C04424
has only substance units: false
name: S-(2-Methylpropanoyl)-dihydrolipoamide
is: CHEBI:17577
is: SBO:0000247
type: Species

metaM fad m
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:16238
is: SBO:0000247
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: C00016
name: Flavin adenine dinucleotide oxidized
is: HMDB01248

metaR r2323
reversible: true
reactant: MODEL1310110027#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110027#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110027#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110027#_720d2c0a_ebd1_4389_8c8a_56aa5ab4cb43
is: SBO:0000252
is: Q9BZM2
initial concentration: NaN
name: PLA2G2F
boundary condition: true
has only substance units: false
is encoded by: hsa:64600
constant: false
type: Species
initial amount: NaN

metaM 2dr1p c
type: Species
initial amount: NaN
name: 2-Deoxy-D-ribose 1-phosphate
is: CHEBI:58576
is: C00672
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
is: HMDB01351

metaR r1384
name: Guanosine aminohydrolase EC:3.5.4.15
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110027#
type: Reaction
reversible: true
kinetic law: MODEL1310110027#
is: SBO:0000176
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_7cb72d71_2b3c_4a9c_8f1f_9bfeff29b219
is encoded by: hsa:6487
has only substance units: false
is: SBO:0000252
is: Q96L53
initial concentration: NaN
boundary condition: true
constant: false
type: Species
initial amount: NaN
name: ST3GAL3

http://identifiers.org/biomodels.db/MODEL1310110027#_27e7336b_4ecc_4402_8e3b_915a95e5739e
has only substance units: false
is: Q13232
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
name: NME3
constant: false
is encoded by: hsa:4832
initial amount: NaN

metaR r2109
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
product: MODEL1310110027#
is: SBO:0000185
reactant: MODEL1310110027#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r1303
type: Reaction
is: SBO:0000185
name: Vesicular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110027#
reversible: false
reactant: MODEL1310110027#
product: MODEL1310110027#

metaR ADSK
name: adenylyl-sulfate kinase
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.1.25
kinetic law: MODEL1310110027#
type: Reaction
is: SBO:0000176
fast: false
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
reversible: false
reactant: MODEL1310110027#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110027#_460e1feb_f705_4506_98fd_2a195bf3674e
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3992
name: FADS1
is: O60427
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_b456590b_96da_4ddb_8bc1_ecd9fa7ad8e9
name: MAN1A2
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is: O60476
is: SBO:0000252
type: Species
is encoded by: hsa:10905

metaR FAOXC226C205m
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C20:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_72a0616f_dcc0_4ad1_89c3_525806b71614
is: SBO:0000252
boundary condition: true
type: Species
name: ALDH9A1
has only substance units: false
is: P49189
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:223
constant: false

metaM so4 m
constant: false
is: HMDB01448
boundary condition: false
initial amount: NaN
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial concentration: 1.0
type: Species
is: CHEBI:16189
is: SBO:0000247
name: sulfate
has only substance units: false

metaM phaccoa c
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C29H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H42N7O17P3S/c1-29(2,24(40)27(41)32-9-8-19(37)31-10-11-57-20(38)12-17-6-4-3-5-7-17)14-50-56(47,48)53-55(45,46)49-13-18-23(52-54(42,43)44)22(39)28(51-18)36-16-35-21-25(30)33-15-34-26(21)36/h3-7,15-16,18,22-24,28,39-40H,8-14H2,1-2H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/p-4/t18-,22-,23-,24+,28-/m1/s1
is: HMDB06503
initial concentration: 1.0
name: phenylacetyl-CoA(4-)
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:57390

metaM HC01376 m
is: CHEBI:28692
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-3-10(2)13(16)18-9-8-11(17)6-4-5-7-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05118
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: S-(2-Methylbutanoyl)-dihydrolipoamide
type: Species
is: SBO:0000247

metaM fald c
type: Species
name: formaldehyde
initial concentration: 1.0
is: CHEBI:16842
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
constant: false
has only substance units: false
is: HMDB01426

metaR r2108
is: SBO:0000185
modifier: MODEL1310110027#
reversible: true
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110027#
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110027#_e3f18831_148b_4bb7_ad79_b855ff5e75e6
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: ENPP1
is: P22413
is encoded by: hsa:5167
has only substance units: false

metaR FAOXC163Gm
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)gm
type: Reaction

metaR r2322
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110027#
is: SBO:0000185
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110027#
reactant: MODEL1310110027#

metaR GLCNACT L
reactant: MODEL1310110027#
reversible: false
kinetic law: MODEL1310110027#
product: MODEL1310110027#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.141 Confidence Level: 0 AUTHORS: NOTES:
name: UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase (liver)
fast: false
type: Reaction
is described by: ECO:0000000

metaM HC02214 e
type: Species
initial amount: NaN
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
is: CHEBI:28852
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: prostaglandin-f1alpha
constant: false
has only substance units: false

metaR HOMt4
reactant: MODEL1310110027#
reversible: false
is: SBO:0000185
modifier: MODEL1310110027#
fast: false
is described by: ECO:0000269
name: L-homoserine via sodium symport
product: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (6541.1) or (84889.1) or (6542.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB

metaM arachd r
is: SBO:0000247
is: CHEBI:32395
constant: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
initial concentration: 1.0
initial amount: NaN
is: HMDB01043
name: arachidonate
type: Species
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_594ea776_bd44_4b3c_a5b2_e7581c795b1c
has only substance units: false
name: _LOC374569_1_e
is encoded by: hsa:LOC374569
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_be4ac17f_f97e_44a2_beb3_0991e36183fc
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: ABCA1
boundary condition: true
has only substance units: false
constant: false
type: Species
is: O95477
is encoded by: hsa:19

metaR r1302
kinetic law: MODEL1310110027#
fast: false
reactant: MODEL1310110027#
product: MODEL1310110027#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
is: SBO:0000185
name: Vesicular transport

metaM pnto R c
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
is: CHEBI:7916
is: HMDB00210
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
name: (R)-Pantothenate
constant: false

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

metaR RE3218C
product: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
is: SBO:0000176
name: RE3218
reactant: MODEL1310110027#
fast: false
modifier: MODEL1310110027#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
is version of: http://identifiers.org/ec-code/3.1.6.2
reversible: true

metaM mi134p c
initial amount: NaN
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243
constant: false
has only substance units: false
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)
is: CHEBI:58414
initial concentration: 1.0
is: SBO:0000247
is: HMDB01143
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_b3183bbb_98c9_43bd_8db3_e9f5357c644e
has only substance units: false
is encoded by: hsa:10396
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is: Q9Y2Q0
name: ATP8A1

metaM btn c
type: Species
boundary condition: false
constant: false
name: Biotin
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: C00120
initial concentration: 1.0
is: CHEBI:3420
is: HMDB00030
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaR PItn
name: phosphate transport, nuclear
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
product: MODEL1310110027#
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

metaM ksi pre21 g
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 21
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C177H284N12O145S6X CHARGE: -7
has only substance units: false
boundary condition: false
is: SBO:0000247
is: C00130
is: CHEBI:58053
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110027#_e6820849_fda8_487f_9ee4_c059d2bdff04
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4726
initial amount: NaN
constant: false
type: Species
name: NDUFS6
is: Q6IBC4
has only substance units: false

metaR DOLPMT4 Ler
reversible: false
product: MODEL1310110027#
type: Reaction
fast: false
kinetic law: MODEL1310110027#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
reactant: MODEL1310110027#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000

metaR r2325
kinetic law: MODEL1310110027#
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
product: MODEL1310110027#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110027#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110027#_94f6eeaa_9460_4d35_9ac6_22988cd93e39
constant: false
initial concentration: NaN
is encoded by: hsa:490
boundary condition: true
is: P20020
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: ATP2B1
type: Species

metaR EX leugly LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylglycine
type: Reaction

metaM dttp c
is: SBO:0000247
is: HMDB01342
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
is: C00459
name: dTTP
boundary condition: false
is: CHEBI:37568
has only substance units: false

metaR RE2651R
product: MODEL1310110027#
name: RE2651
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
reversible: true
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110027#_7bc091a8_b47d_46f0_ae74_f55df2c606bc
is: SBO:0000252
initial concentration: NaN
constant: false
is: B3KXY9
type: Species
has only substance units: false
name: HK1
boundary condition: true
initial amount: NaN
is encoded by: hsa:3098

metaM 56dthm c
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
initial amount: NaN
is: CHEBI:27468
has only substance units: false
constant: false
name: 5,6-dihydrothymine
is: HMDB00079
initial concentration: 1.0
type: Species

metaR CYSGLUexR
reactant: MODEL1310110027#
reversible: true
name: L-cysteine/L-glutamine reversible exchanger
kinetic law: MODEL1310110027#
fast: false
is described by: ECO:0000304
product: MODEL1310110027#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110027#
type: Reaction

metaM h2o r
is: C00001
initial concentration: 1.0
constant: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
type: Species
is: HMDB02111
boundary condition: false
is: CHEBI:15377
name: H2O
is: SBO:0000247
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_9c09261f_734d_4b5d_b9e7_edef9b0498b1
initial concentration: NaN
has only substance units: false
type: Species
name: LDHB
is: P07195
boundary condition: true
is encoded by: hsa:3945
initial amount: NaN
constant: false
is: SBO:0000252

metaR NCKt
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
fast: false
type: Reaction
modifier: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000269
product: MODEL1310110027#
kinetic law: MODEL1310110027#
reversible: true
name: Na+/Ca2+-K+ exchange
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110027#_c3db1915_be64_4f4d_97b0_c29a9df0c04b
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:AI620219
name: _AI620219_1_e
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_cad60dd7_70ed_47f6_8392_05375af2ab76
boundary condition: true
has only substance units: false
type: Species
name: GCNT4
is encoded by: hsa:51301
is: SBO:0000252
is: Q9P109
constant: false
initial amount: NaN
initial concentration: NaN

metaR FAOXC14C12m
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)m
type: Reaction

metaM ade e
is: CHEBI:16708
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00034
constant: false
type: Species
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
is: SBO:0000247
name: adenine
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_6667090f_6e66_489e_9b50_249a9f032d6d
name: OCRL
boundary condition: true
initial concentration: NaN
constant: false
is: Q01968
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4952

metaR NAIt
reversible: true
type: Reaction
modifier: MODEL1310110027#
is described by: ECO:0000269
name: Na+ / iodide cotransport
is: SBO:0000185
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
fast: false

http://identifiers.org/biomodels.db/MODEL1310110027#_385b0899_80fc_4678_b021_bdb0842a9721
constant: false
boundary condition: true
name: IDH3A
is: P50213
is encoded by: hsa:3419
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species

metaM orn e
is: HMDB00214
is: C01602
is: CHEBI:0
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
name: Ornithine
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H13N2O2 CHARGE: 1

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

metaM c226crn c
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/127055
has only substance units: false
initial concentration: 1.0
name: cervonyl carnitine
is: HMDB06510
constant: false
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+

metaM uacgam g
has only substance units: false
is: CHEBI:57705
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB00290
is: SBO:0000247
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
boundary condition: false

metaR r2324
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110027#
reversible: true
reactant: MODEL1310110027#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110027#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR r1304
fast: false
reactant: MODEL1310110027#
name: Vesicular transport
kinetic law: MODEL1310110027#
product: MODEL1310110027#
type: Reaction
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185

metaR r1030
reversible: true
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
name: Transport reaction
product: MODEL1310110027#
fast: false
is: SBO:0000185
type: Reaction

metaR AKGMALtm
reversible: true
reactant: MODEL1310110027#
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
is: SBO:0000185
modifier: MODEL1310110027#
name: alpha-ketoglutarate/malate transporter
type: Reaction
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_b590be62_ec2b_4004_8b09_9b9cde38b950
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:8867
name: SYNJ1
initial amount: NaN
is: O43426
is: SBO:0000252
type: Species

metaM prostgi2 r
is: CHEBI:57403
is: SBO:0000247
constant: false
name: prostaglandin I2(1-)
has only substance units: false
is: HMDB01335
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312

metaM HC02214 c
constant: false
type: Species
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:28852
name: prostaglandin-f1alpha
is: SBO:0000247
has only substance units: false

metaM thbpt c
is: CHEBI:15372
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
boundary condition: false
type: Species
name: 5,6,7,8-tetrahydrobiopterin
has only substance units: false
is: SBO:0000247
is: HMDB00027
constant: false
initial concentration: 1.0
initial amount: NaN

metaR FUMTSULtm
is: SBO:0000185
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
fast: false
is described by: ECO:0000269
name: Fumarate:thiosulfate antiport, mitochondrial
reversible: true
type: Reaction
modifier: MODEL1310110027#
product: MODEL1310110027#

metaM bilglcur e
name: mono(glucosyluronic acid)bilirubin(2-)
initial concentration: 1.0
is: CHEBI:57767
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false

metaR STRDNCt
reactant: MODEL1310110027#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110027#
is: SBO:0000185
reversible: true
product: MODEL1310110027#
is described by: ECO:0000000
name: fatty acid transport via diffusion

metaM asn L c
name: L-asparagine
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB00168
is: CHEBI:17196
type: Species
initial amount: NaN
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
constant: false
initial concentration: 1.0

metaR r1380
type: Reaction
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
is described by: ECO:0000000
product: MODEL1310110027#
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
reactant: MODEL1310110027#
fast: false

metaR MM7Cbg
notes: GENE_ASSOCIATION: (57134.1) or (10905.1) or (4121.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
fast: false
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110027#
type: Reaction
reversible: false
product: MODEL1310110027#
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.2.1.113
kinetic law: MODEL1310110027#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110027#_d7f96c32_0407_4589_a6fa_3847ce5db9f1
type: Species
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:81490
is: Q9BVG9
boundary condition: true
initial amount: NaN
name: PTDSS2

metaM dttp e
is: CHEBI:37568
has only substance units: false
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
type: Species
is: HMDB01342
initial concentration: 1.0
name: dTTP(4-)
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_d7c66329_8da5_4c31_88b2_5e6a2dfa90d2
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:89869
is: Q86YW0
initial amount: NaN
name: PLCZ1
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110027#_342a9775_2671_4053_81d7_5176c0e6a186
has only substance units: false
is encoded by: hsa:AF116616
boundary condition: true
constant: false
type: Species
name: _AF116616_1_m
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaM arachd e
initial amount: NaN
type: Species
constant: false
boundary condition: false
is: HMDB01043
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
name: arachidonate
is: CHEBI:32395
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaR GFUCS
is: SBO:0000176
reversible: false
type: Reaction
reactant: MODEL1310110027#
product: MODEL1310110027#
name: GDP-L-fucose synthase
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.271 Confidence Level: 0 AUTHORS: NOTES:Both human and Escherichia coli enzymes can use NADH in place of NADPH to a slight extent. IT
is version of: http://identifiers.org/ec-code/1.1.1.271
kinetic law: MODEL1310110027#
is described by: ECO:0000000
modifier: MODEL1310110027#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110027#_0aca4412_7b84_4e53_ac59_ba192018cbbd
name: ACAT1
initial amount: NaN
is: P24752
is encoded by: hsa:38
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_51db7600_dbe0_42f8_af83_4f8c740c0656
is encoded by: hsa:F23536
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
name: _F23536_1_m
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_bbae3067_c0b3_41f5_bfc6_524a2ec72124
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3033
initial amount: NaN
name: HADH
initial concentration: NaN
constant: false
is: Q16836
type: Species

metaM ksi pre3 g
is: HMDB00175
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58053
constant: false
is: C00130
type: Species
name: keratan sulfate I biosynthesis, precursor 3
is: SBO:0000247
notes: FORMULA: C93H152N6O67X CHARGE: -1
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110027#_e9a71bda_b2c5_4daa_bdf5_fac9bd2986bb
has only substance units: false
is: O43280
boundary condition: true
name: TREH
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:11181
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_8ef0df6b_8811_41ff_ae7d_f5ec95f501b9
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:112
name: ADCY6
is: O43306
type: Species
boundary condition: true

metaR EX paf hs LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-acteylglycerol 3-phosphocholine (homo sapiens) exchange
type: Reaction

metaR r0339
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.65
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.1.2.2
reversible: false
product: MODEL1310110027#
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.2.22

metaR MI145PK
is: SBO:0000176
name: inositol-1,4,5-trisphosphate 3-kinase
is described by: ECO:0000269
product: MODEL1310110027#
reversible: false
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.1.127
reactant: MODEL1310110027#
fast: false

metaR r1459
type: Reaction
fast: false
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110027#
reversible: true
is described by: ECO:0000000
is: SBO:0000185

metaM c10dc x
notes: FORMULA: C17H30NO6 CHARGE: -1
is: SBO:0000247
is: C14143
has only substance units: false
type: Species
is: HMDB04047
boundary condition: false
constant: false
initial amount: NaN
name: sebacoyl carnitine
initial concentration: 1.0

metaR r0081
is version of: http://identifiers.org/ec-code/1.5.1.12
type: Reaction
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
name: L-Alanine:2-oxoglutarate aminotransferase Glutamate metabolism / Alanine and aspartate metabolism EC:2.6.1.2
is: SBO:0000176
product: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Citric acid cycle EC Number: 2.6.1.2 Confidence Level: 0 AUTHORS: PMID:15663181,PMID:2088925,PMID:454616 NOTES:
fast: false
is described by: ECO:0000000
reversible: true

metaM omhdecacid c
boundary condition: false
is: HMDB01022
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
name: w-hydroxydecanoicacid
initial concentration: 1.0
type: Species
notes: FORMULA: C10H19O3 CHARGE: -1

metaR ACOAO7p
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (51.1) or (51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: PMID:7876265,PMID:8159712 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
modifier: MODEL1310110027#
type: Reaction
fast: false
is described by: ECO:0000269
reversible: false
product: MODEL1310110027#
name: acyl-CoA oxidase (hexadecanoyl-CoA), peroxisomal
reactant: MODEL1310110027#

metaM prostgi2 c
is: HMDB01335
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: prostaglandin I2(1-)
has only substance units: false
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
is: SBO:0000247
type: Species
is: CHEBI:57403

metaM orn c
initial concentration: 1.0
is: C01602
type: Species
constant: false
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: HMDB00214
is: CHEBI:0
initial amount: NaN
boundary condition: false
has only substance units: false
name: Ornithine
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_830ef1fa_d846_4707_bfb2_4597f52603ce
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6568
name: SLC17A1
type: Species
initial amount: NaN
constant: false
is: Q14916

metaM strdnc c
name: stearidonic acid C18:4, n-3
is: HMDB06547
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
constant: false
is: C16300
type: Species
has only substance units: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205608

metaM lnlncacoa c
initial amount: NaN
initial concentration: 1.0
is: HMDB06290
is: CHEBI:51985
has only substance units: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,26-28,32-34,38,49-50H,4,7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE4809
name: alpha-Linolenoyl-CoA
constant: false
type: Species
boundary condition: false
is: SBO:0000247

metaM asn L e
is: SBO:0000247
has only substance units: false
is: CHEBI:17196
type: Species
constant: false
name: L-asparagine
is: HMDB00168
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148

http://identifiers.org/biomodels.db/MODEL1310110027#_0a7b1b1e_2c61_4e95_8254_0eca45ae1194
boundary condition: true
is encoded by: hsa:AI435857
initial concentration: NaN
name: _AI435857_1_x
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_353d7bdb_26da_4610_91c6_e9a820b50f58
name: FTCD
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:10841
type: Species

metaM ethamp r
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00224
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
is: CHEBI:58190
name: O-phosphonatoethanaminium(1-)
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaM l2fn2m2masn g
boundary condition: false
is: CHEBI:28067
type: Species
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C68H113N4O49X CHARGE: 0
initial amount: NaN
name: {[galactosyl-(1,4)-N-Acetyl-glucosaminyl-(1,2)-mannosyl-(1,3)-],[N-acetyl-glucosaminyl-(1,2)-mannosyl-(1,6)-]mannosyl-(1,4)-N-acetyl-glucosaminyl-(1,4)-[fucosyl-(1,6)]-N-acetyl-glucosaminyl}asparagine

metaR NDPK6n
type: Reaction
is: SBO:0000176
reactant: MODEL1310110027#
modifier: MODEL1310110027#
fast: false
product: MODEL1310110027#
kinetic law: MODEL1310110027#
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
reversible: true
is described by: ECO:0000304

metaR r1301
fast: false
type: Reaction
kinetic law: MODEL1310110027#
is described by: ECO:0000000
name: Vesicular transport
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: false
reactant: MODEL1310110027#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110027#_b9ac5f26_c4a0_4a65_800a_e2d8b2359c3c
initial amount: NaN
name: SLC25A4
is: P12235
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:291
boundary condition: true
type: Species
is: SBO:0000252

metaM tdchola x
is: HMDB00951
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:9407
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
initial amount: NaN
constant: false
boundary condition: false
name: taurochenodeoxycholate

http://identifiers.org/biomodels.db/MODEL1310110027#_367fc863_e383_4c17_8d71_bfaf3ff3936e
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: C1GALT1
initial amount: NaN
boundary condition: true
is: Q9NS00
constant: false
is encoded by: hsa:56913

metaM arachd c
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
name: arachidonate
type: Species
has only substance units: false
constant: false
is: HMDB01043
is: CHEBI:32395
initial concentration: 1.0
is: SBO:0000247

metaM bilglcur c
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
is: CHEBI:57767
has only substance units: false
is: SBO:0000247
constant: false
name: mono(glucosyluronic acid)bilirubin(2-)
initial amount: NaN

metaM dhf l
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
boundary condition: false
is: CHEBI:57451
has only substance units: false
name: dihydrofolate(2-)
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB01056
initial amount: NaN
type: Species

metaR SEBCOAPET
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of sebacoylcoa for release into cytosol
type: Reaction

metaR ADK1
name: adenylate kinase
reversible: true
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.3
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
reactant: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
product: MODEL1310110027#

metaM ksii core4 pre10 g
is: CHEBI:28067
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 10
boundary condition: false
notes: FORMULA: C89H143N7O69S2X CHARGE: -3
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_1b0eefc7_9499_4050_9688_9e473798c9ab
is: SBO:0000252
has only substance units: false
is encoded by: hsa:30
constant: false
is: Q96CA6
initial concentration: NaN
name: ACAA1
type: Species
initial amount: NaN
boundary condition: true

metaM o2s e
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: SBO:0000247
is: HMDB02168
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
name: superoxide
boundary condition: false
constant: false
is: CHEBI:18421

metaR AMPtp
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ
kinetic law: MODEL1310110027#
is described by: ECO:0000000
reactant: MODEL1310110027#
type: Reaction
name: AMP transporter, peroxisome
product: MODEL1310110027#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110027#_ff280890_b0fe_4aca_b51b_65f2339c5166
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: SLC4A1
constant: false
is: P02730
is encoded by: hsa:6521
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_ea550327_ef06_41f7_8bf5_cf1faf5eb0a6
constant: false
has only substance units: false
type: Species
is: P32119
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: PRDX2
is encoded by: hsa:7001

metaR ACCOAC
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_4fd1f520_aa69_450e_9475_286fd59244e2
name: SLC22A2
has only substance units: false
type: Species
is: O15244
initial concentration: NaN
constant: false
is encoded by: hsa:6582
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR ADSL1
fast: false
is: SBO:0000176
modifier: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
name: adenylosuccinate lyase
product: MODEL1310110027#
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/4.3.2.2
reversible: false

metaR r2079
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110027#
modifier: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#
reversible: true
fast: false
is described by: ECO:0000000

metaR r0679
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110027#
type: Reaction
reversible: true
product: MODEL1310110027#
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.3.1.16
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
fast: false
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:

metaR FAOXC14C12x
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)x
type: Reaction

metaM pnto R e
type: Species
is: HMDB00210
name: (R)-Pantothenate
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:7916
initial amount: NaN
has only substance units: false
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568

metaR r0149
modifier: MODEL1310110027#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110027#
reversible: true
reactant: MODEL1310110027#
is described by: ECO:0000000
product: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
is version of: http://identifiers.org/ec-code/1.14.13.39

metaM ump n
boundary condition: false
is: HMDB00288
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
constant: false
type: Species
initial amount: NaN
is: CHEBI:57865
has only substance units: false
name: UMP(2-)
is: SBO:0000247
initial concentration: 1.0

metaR DOLPMT3 Ler
reversible: false
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110027#
type: Reaction
is: SBO:0000176
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.4.1.260
reactant: MODEL1310110027#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
kinetic law: MODEL1310110027#
is described by: ECO:0000000
fast: false

metaM dhf m
is: HMDB01056
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
boundary condition: false
initial amount: NaN
is: CHEBI:57451
type: Species
name: dihydrofolate(2-)
initial concentration: 1.0

metaR C160CPT2
is described by: ECO:0000269
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TV
product: MODEL1310110027#
reactant: MODEL1310110027#
reversible: false
type: Reaction
fast: false
name: C160 transport into the mitochondria
is: SBO:0000176
modifier: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_b2cfae6b_a95a_4e20_b329_45b23238339e
constant: false
is encoded by: hsa:11001
initial concentration: NaN
is: SBO:0000252
name: SLC27A2
has only substance units: false
is: O14975
initial amount: NaN
boundary condition: true
type: Species

metaM prostgi2 e
name: prostaglandin I2(1-)
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
is: CHEBI:57403
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB01335

metaM strdnc e
initial amount: NaN
is: SBO:0000247
name: stearidonic acid C18:4, n-3
constant: false
boundary condition: false
is: C16300
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
type: Species
is: http://identifiers.org/pubchem.compound/47205608
has only substance units: false
initial concentration: 1.0
is: HMDB06547

metaM q10h2 m
initial concentration: 1.0
name: Ubiquinol-10
is: HMDB13111
boundary condition: false
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/6504740
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324

metaM o2 x
is: C00007
type: Species
constant: false
boundary condition: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial amount: NaN
has only substance units: false
is: HMDB01377
is: CHEBI:15379
is: SBO:0000247
name: O2
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110027#_3a86e688_cb88_4d0d_b584_4943dbded3de
is: SBO:0000252
is: P06858
boundary condition: true
is encoded by: hsa:4023
name: LPL
has only substance units: false
initial amount: NaN
constant: false
type: Species
initial concentration: NaN

metaR TDCHOLAtx
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
product: MODEL1310110027#
is: SBO:0000185
kinetic law: MODEL1310110027#
name: bile acid intracellular transport
type: Reaction
reactant: MODEL1310110027#

metaM gdp c
constant: false
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB01201
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
name: GDP
is: C00035
is: CHEBI:58189
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_2ba81d58_534b_4a23_afde_db5954ee29a8
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: COX4I1
is encoded by: hsa:1327
is: P13073
has only substance units: false
constant: false

metaR ADSL2
name: adenylosuccinate lyase
kinetic law: MODEL1310110027#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.3.2.2
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Purine synthesis EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
is described by: ECO:0000269
reversible: false
type: Reaction
modifier: MODEL1310110027#
product: MODEL1310110027#

metaR RE3004M
fast: false
reversible: true
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
modifier: MODEL1310110027#
product: MODEL1310110027#
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE3004
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/4.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110027#_056c324f_404d_4138_a158_3620c9abdbcd
is encoded by: hsa:4694
initial concentration: NaN
name: NDUFA1
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: Q6IBB5
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110027#_8a1d5d58_5201_4658_8791_49b89a2794a6
has only substance units: false
name: UEVLD
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:55293
is: Q8IX04
type: Species

metaR r0086
is version of: http://identifiers.org/ec-code/3.5.1.3
type: Reaction
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
is: SBO:0000176
reactant: MODEL1310110027#
reversible: false
product: MODEL1310110027#
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
fast: false
is described by: ECO:0000000
modifier: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_23f8749d_0a0d_4290_85d6_c5a0534cff51
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
is: O43511
initial amount: NaN
is encoded by: hsa:5172
constant: false
boundary condition: true
name: SLC26A4

http://identifiers.org/biomodels.db/MODEL1310110027#_4838eedc_a8f9_4d44_80ae_1009aec44cea
type: Species
is: P49748
name: ACADVL
is: SBO:0000252
constant: false
is encoded by: hsa:37
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaR r0560
type: Reaction
product: MODEL1310110027#
is: SBO:0000176
reversible: false
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:

metaR GALASE17ly
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110027#

metaM dutp c
has only substance units: false
is: C00460
initial concentration: 1.0
initial amount: NaN
is: HMDB01191
is: CHEBI:17625
boundary condition: false
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
constant: false
is: SBO:0000247
type: Species
name: dUTP

metaM fad e
is: C00016
boundary condition: false
name: Flavin adenine dinucleotide oxidized
constant: false
is: HMDB01248
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:16238
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016

metaR METtec
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110027#
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
reversible: true
type: Reaction
reactant: MODEL1310110027#
name: L-methionine transport via diffusion (extracellular to cytosol)
modifier: MODEL1310110027#
is: SBO:0000185

metaR ITCOALm
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
product: MODEL1310110027#
reversible: true
modifier: MODEL1310110027#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
is version of: http://identifiers.org/ec-code/6.2.1.4
is described by: ECO:0000212
is version of: http://identifiers.org/ec-code/6.2.1.5
type: Reaction
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
fast: false

metaM ksii core4 pre4 g
boundary condition: false
notes: FORMULA: C61H99N5O43X CHARGE: -1
is: CHEBI:58053
initial concentration: 1.0
initial amount: NaN
is: C00130
is: HMDB00175
type: Species
is: SBO:0000247
constant: false
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 4

metaR LTD4DP
product: MODEL1310110027#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
is: SBO:0000176
reversible: true
fast: false
name: Leukotriene D4 dipeptidase

metaR CYSGLNNaEx
type: Reaction
name: L-cysteine/L-glutamine Na-dependent exchange (Cys-L in)
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
fast: false
modifier: MODEL1310110027#
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110027#
reversible: false

metaM glx x
boundary condition: false
type: Species
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:36655
is: HMDB00119
name: glyoxylate
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048

metaR EX oxa LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Oxalate exchange
type: Reaction

metaM lnlncgcoa c
name: gamma-linolenoyl-CoA(4-)
type: Species
is: HMDB06368
initial amount: NaN
has only substance units: false
is: CHEBI:57363
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110027#_f051161b_61a7_4ce3_b7ea_81ba5f1efdc7
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10559
type: Species
initial concentration: NaN
is: P78382
constant: false
boundary condition: true
name: SLC35A1

http://identifiers.org/biomodels.db/MODEL1310110027#_bc633530_9ced_4d7b_8918_5f7243bf18c4
initial concentration: NaN
is: Q9H2U2
type: Species
initial amount: NaN
boundary condition: true
name: PPA2
constant: false
is encoded by: hsa:27068
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_b3aaa1a3_52a0_4e16_90d6_61d7eaafa0cd
is encoded by: hsa:11182
boundary condition: true
type: Species
initial concentration: NaN
name: SLC2A6
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
is: Q9UGQ3

metaM o2s c
is: CHEBI:18421
constant: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB02168
boundary condition: false
name: superoxide
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_0499c355_7c5c_4252_b419_07fb5967fb98
name: DHCR7
initial concentration: NaN
is encoded by: hsa:1717
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
is: Q9UBM7

metaR NADHtpu
is: SBO:0000185
reactant: MODEL1310110027#
fast: false
product: MODEL1310110027#
kinetic law: MODEL1310110027#
is described by: ECO:0000000
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
name: NADH transporter, peroxisome

metaR r0085
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.42
product: MODEL1310110027#
is: SBO:0000176
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110027#
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3

http://identifiers.org/biomodels.db/MODEL1310110027#_c0d5e4f0_13d4_47d4_a462_09c6b6cc4706
is encoded by: hsa:92745
name: SLC38A5
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
is: Q8WUX1

metaR CHAT
type: Reaction
modifier: MODEL1310110027#
name: Choline O-acetyltransferase
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
fast: false
is described by: ECO:0000269
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.6
product: MODEL1310110027#
kinetic law: MODEL1310110027#

metaR r0074
reactant: MODEL1310110027#
type: Reaction
fast: false
modifier: MODEL1310110027#
is described by: ECO:0000000
is: SBO:0000176
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/6.2.1.1
reversible: true
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110027#_badd8d79_b4d7_47e1_a85b_af3e2e31d06b
type: Species
boundary condition: true
is: Q92959
is encoded by: hsa:6578
name: SLCO2A1
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR C6COAt
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: esterification of of hexanoylcoa for transport into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_eb9c845b_7baf_43e1_9684_f83f932d4b77
type: Species
name: AMPD2
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:271
initial amount: NaN
boundary condition: true
is: B2RB47
initial concentration: NaN

metaR PACCOAL
reversible: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 6.2.1.30 Confidence Level: 2 AUTHORS: NOTES:JLR
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
fast: false
product: MODEL1310110027#
name: phenylacetate-CoA ligase

http://identifiers.org/biomodels.db/MODEL1310110027#_d67eb61f_5df8_4fd9_bb77_e7d5d8f597d5
initial amount: NaN
is: Q76EJ3
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: SLC35D2
is encoded by: hsa:11046
constant: false

metaM 4nphsf e
constant: false
type: Species
is: HMDB06492
is: SBO:0000247
is: CHEBI:35422
initial amount: NaN
name: 4-Nitrophenyl sulfate
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaM thymd c
boundary condition: false
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
type: Species
is: SBO:0000247
is: C00214
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:17748
is: HMDB00273
constant: false
name: Thymidine

http://identifiers.org/biomodels.db/MODEL1310110027#_4c01c167_59be_43e2_8ca4_82c26a7953f9
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
is: O75106
constant: false
is encoded by: hsa:314
name: AOC2
initial amount: NaN

metaM h2o x
has only substance units: false
name: H2O
boundary condition: false
constant: false
is: CHEBI:15377
initial concentration: 1.0
type: Species
is: C00001
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: SBO:0000247
is: HMDB02111
initial amount: NaN

metaM dag hs c
name: diglyceride
initial amount: NaN
is: CHEBI:18035
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false

metaM met L e
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB00696
name: L-methionine
type: Species
is: CHEBI:16643
constant: false
initial concentration: 1.0
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075

metaM o2 r
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: HMDB01377
is: SBO:0000247
is: C00007
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
name: O2
is: CHEBI:15379
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_e95ecdfc_47cb_4bc6_8f18_9b34878b57aa
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:175
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
name: AGA
is: P20933

metaR PItg
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110027#
name: phosphate transport, Golgi apparatus
reversible: false
type: Reaction
fast: false
kinetic law: MODEL1310110027#

metaM fad c
is: C00016
is: CHEBI:16238
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
name: Flavin adenine dinucleotide oxidized
boundary condition: false
initial amount: NaN
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
type: Species
is: HMDB01248

metaR RE2658R
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
name: RE2658
reversible: true
product: MODEL1310110027#
fast: false
is described by: ECO:0000000
is: SBO:0000176

metaR SUCOAS1m
is described by: ECO:0000000
modifier: MODEL1310110027#
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/6.2.1.4
reactant: MODEL1310110027#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
type: Reaction
reversible: true
name: Succinate--CoA ligase (GDP-forming)
kinetic law: MODEL1310110027#

metaR HACD9m
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110027#
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
is described by: ECO:0000134
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid

metaR ALACYSNaEx
modifier: MODEL1310110027#
is described by: ECO:0000269
reactant: MODEL1310110027#
name: L-alanine/L-cysteine Na-dependent exchange (Ala-L in)
fast: false
kinetic law: MODEL1310110027#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110027#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_a7ece316_083f_47cb_9f44_f520d804bc4f
is encoded by: hsa:4724
is: O43181
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
name: NDUFS4
has only substance units: false
type: Species
boundary condition: true

metaR CYTK12n
modifier: MODEL1310110027#
reversible: true
name: cytidylate kinase (dCMP,dCTP),nuclear
fast: false
is described by: ECO:0000269
reactant: MODEL1310110027#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110027#
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14

http://identifiers.org/biomodels.db/MODEL1310110027#_738f7ac9_5326_48a3_8fe6_f7b8b18c775a
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110027#_55e89dd8_730d_4545_a6eb_932ffa5e3aed
is encoded by: hsa:6482
is: Q11201
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
type: Species
name: ST3GAL1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_6ea93715_4d54_47f6_8ee6_69258bb59512
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4698
is: Q16718
is: SBO:0000252
name: NDUFA5
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_8cd7cc1d_15b3_40b5_aa78_b932fa1bf820
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:AL038231
name: _AL038231_1_c
type: Species

metaM uri n
name: uridine
constant: false
initial amount: NaN
is: CHEBI:16704
notes: FORMULA: C9H12N2O6 CHARGE: 0 INCHI: InChI=1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00296
is: SBO:0000247
boundary condition: false

metaR SIAASEly
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110027#
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: sialidase, lysosomal
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
kinetic law: MODEL1310110027#
is: SBO:0000176
reversible: false

metaR RE1342C
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
fast: false
type: Reaction
product: MODEL1310110027#
kinetic law: MODEL1310110027#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110027#
reversible: true
name: RE1342

http://identifiers.org/biomodels.db/MODEL1310110027#_4a679294_78d4_4081_978a_a2c2ea2826a5
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:8694
constant: false
has only substance units: false
boundary condition: true
name: DGAT1
type: Species
is: O75907
is: SBO:0000252

metaR DM gpi sig er
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gpi sig(er)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_62239eae_4416_4fd1_8e05_85aa26b284bc
is encoded by: hsa:5335
boundary condition: true
constant: false
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
name: PLCG1
is: Q9UFY1
initial concentration: NaN

metaR THYMt
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
modifier: MODEL1310110027#
is described by: ECO:0000269
kinetic law: MODEL1310110027#
fast: false
name: thymine reversible transport via facilated diffusion
product: MODEL1310110027#
type: Reaction
reversible: true
reactant: MODEL1310110027#
is: SBO:0000185

metaM co e
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
name: carbon monoxide
is: SBO:0000247
is: HMDB01361
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
is: CHEBI:17245
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_fc3aee2d_b4dd_49f2_86d9_6912f960848f
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:30814
is: Q9NZK7
type: Species
initial amount: NaN
constant: false
name: PLA2G2E
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110027#_88e6864b_927a_4ba9_b998_297ad717079a
is encoded by: hsa:AA081045
constant: false
name: _AA081045_1_e
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR TYROXDAc
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.4.3.4
reactant: MODEL1310110027#
name: Tyramine:oxygen oxidoreductase(deaminating)(flavin-containing) (cytosol)
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.6 Confidence Level: 4 AUTHORS: PMID:11336106,PMID:14697899,PMID:8255365 NOTES:SAB also 1.4.3.4
modifier: MODEL1310110027#
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110027#
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_71119174_f338_4aed_8256_b56fd10d9799
name: NAGA
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
is: P17050
initial concentration: NaN
is encoded by: hsa:4668
constant: false
initial amount: NaN

metaR r0083
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is version of: http://identifiers.org/ec-code/1.1.1.42
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110027#
product: MODEL1310110027#
fast: false
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110027#_e6c0c579_1aa5_4168_9294_cdff8bd753b4
constant: false
is: SBO:0000252
name: CTSA
initial amount: NaN
is: P10619
is encoded by: hsa:5476
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110027#_fd8ca4c0_6625_4842_bc93_30662f4655f2
type: Species
name: _W74642_1_c
is encoded by: hsa:W74642
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false

metaM 4nphsf c
has only substance units: false
is: SBO:0000247
name: 4-Nitrophenyl sulfate
boundary condition: false
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
is: CHEBI:35422
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
is: HMDB06492

metaR BILIRUBtr
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is: SBO:0000185
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
fast: false
product: MODEL1310110027#
type: Reaction
reversible: true
name: lipid, flip-flop intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110027#_e05809e4_f672_4dfe_8a35_ffb6c8fd6f74
is encoded by: hsa:5291
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
has part: B4DER4
is: SBO:0000297
name: PIK3CB:PIK3R1
type: Species
initial amount: NaN
has part: B3KT19
is encoded by: hsa:5295

http://identifiers.org/biomodels.db/MODEL1310110027#_87384764_32df_43a8_a8c1_983842edc655
has only substance units: false
initial concentration: NaN
name: GNPNAT1
is: SBO:0000252
is: Q96EK6
is encoded by: hsa:64841
constant: false
boundary condition: true
type: Species
initial amount: NaN

metaR r0145
kinetic law: MODEL1310110027#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
modifier: MODEL1310110027#
fast: false
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
reactant: MODEL1310110027#
is described by: ECO:0000000
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.8.3.1
reversible: true

metaM ump r
is: HMDB00288
initial amount: NaN
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: SBO:0000247
name: UMP
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
is: CHEBI:57865
boundary condition: false

metaM HC00822 e
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:28681
boundary condition: false
name: Chitobiose
notes: FORMULA: C16H28N2O11 CHARGE: 0 INCHI: InChI=1S/C16H28N2O11/c1-5(21)17-9-13(25)14(8(4-20)27-15(9)26)29-16-10(18-6(2)22)12(24)11(23)7(3-19)28-16/h7-16,19-20,23-26H,3-4H2,1-2H3,(H,17,21)(H,18,22)/t7-,8-,9-,10-,11-,12-,13-,14-,15?,16+/m1/s1 EHMN_ABBREVIATION: C01674
has only substance units: false

metaM pmtcoa x
name: Palmitoyl-CoA (n-C16:0CoA)
initial concentration: 1.0
is: CHEBI:57379
is: SBO:0000247
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
is: HMDB01338
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
type: Species
is: C00154

metaR EX uri LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Uridine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_4016e859_272b_4fc9_96a4_ea8578e7a853
constant: false
name: LHPP
type: Species
is: SBO:0000252
initial amount: NaN
is: Q9H008
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:64077

metaR ALAGLYexR
is described by: ECO:0000304
is: SBO:0000185
reversible: true
product: MODEL1310110027#
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
modifier: MODEL1310110027#
fast: false
type: Reaction
name: L-alanine/glycine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

MODEL1310110027
reaction: metaR ITCOAL1m
species: metaM adp c
reaction: metaR G14T19g
reaction: metaR 7DHCHSTEROLtr
species: metaM retinal 11 cis c
reaction: metaR r1435
reaction: metaR EX asn L LPAREN e RPAREN
reaction: metaR AMETt2m
species: metaM dhf l
reaction: metaR r2081
reaction: metaR PIter
species: metaM sphs1p r
reaction: metaR r2128
species: metaM nh4 x
reaction: metaR EX prostgd2 LPAREN e RPAREN
reaction: metaR EX dgsn LPAREN e RPAREN
species: metaM biliverd c
reaction: metaR r0181
species: metaM prostgh2 e
reaction: metaR r1889
reaction: metaR GLYCtm
species: metaM gln L e
reaction: metaR r2137
reaction: metaR r1659
reaction: metaR OCD11CRNCACT
reaction: metaR FAOXC164C165m
reaction: metaR PEt
reaction: metaR 2HBO
species: metaM ps hs c
reaction: metaR GLYSNAT5tc
species: metaM pail45p hs n
reaction: metaR RE1447M
species: metaM lnlncgcoa r
reaction: metaR r2121
reaction: metaR PGK
reaction: metaR M14NTg
reaction: metaR r1565
species: metaM k c
reaction: metaR EX ctp LPAREN e RPAREN
reaction: metaR r1652
reaction: metaR r1940
reaction: metaR r0842
reaction: metaR ETHAK
reaction: metaR r0392
reaction: metaR HAS1
species: metaM crm hs r
reaction: metaR SCP22x
reaction: metaR HEX1
species: metaM q10 e
reaction: metaR HPYRR2x
species: metaM L2aadp c
species: metaM crn r
reaction: metaR ORNLEUrBATtc
reaction: metaR KSII CORE4tly
reaction: metaR GLYCTDle
reaction: metaR DOLPMT4 Ler
reaction: metaR ACGAMtly
species: metaM trdox m
reaction: metaR EX dopa LPAREN e RPAREN
species: metaM adp m
reaction: metaR PIt7
reaction: metaR DHAAt1r
species: metaM 1p3h5c m
reaction: metaR FE3R2e
reaction: metaR 4NPHSULT
species: metaM fad e
species: metaM aprgstrn c
reaction: metaR GLYt7 211 r
species: metaM retinal cis 9 c
reaction: metaR r0603
species: metaM HC02210 c
reaction: metaR CO2t
reaction: metaR ALAGLNexR
reaction: metaR r2095
species: metaM dopasf c
reaction: metaR r0990
reaction: metaR S6T7g
reaction: metaR O2tp
species: metaM udp g
species: metaM stcoa c

metaR OMHDEACIDTD
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of w-hydroxydecanoic acid by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_8ae43e46_d466_4d35_b998_42924646d8f4
type: Species
is encoded by: hsa:10870
has part: P48736
has part: Q9UBK5
initial amount: NaN
boundary condition: true
is: SBO:0000297
initial concentration: NaN
name: HCST:PIK3CG
is encoded by: hsa:5294
constant: false
has only substance units: false

metaR PROSTGI2tr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
name: Prostaglandin I2 transport (ER)
reversible: true
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
product: MODEL1310110027#
is described by: ECO:0000269
fast: false
type: Reaction
is: SBO:0000185

metaM dgpi prot hs r
is: http://identifiers.org/pubchem.compound/7847414
initial amount: NaN
is: D00348
notes: FORMULA: C39H76N4O37P4FULLRCO2FULLR2CO2X CHARGE: 0
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB06219
name: deacylated-glycophosphatidylinositol (GPI)-anchored protein
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110027#_83cc94a9_20cd_495c_9a1b_bea29550b90b
is encoded by: hsa:28976
is: SBO:0000252
name: ACAD9
boundary condition: true
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is: Q9H845

http://identifiers.org/biomodels.db/MODEL1310110027#_c8f9e504_0db1_4bb9_8808_7de76a247b45
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4125
name: MAN2B1
boundary condition: true
is: O00754
initial concentration: NaN

metaM dttp m
boundary condition: false
name: dTTP
constant: false
has only substance units: false
type: Species
is: HMDB01342
initial amount: NaN
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: CHEBI:37568
is: C00459
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110027#_8ed0729d_1bb7_4c18_9e28_4a0f1961f09e
has only substance units: false
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:10861
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: SLC26A1

metaR IDPtn
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110027#
name: IDP nuclear transport
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110027#
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_bfe1fb7f_d11b_4ac0_a6e0_b69fe3d295c8
has only substance units: false
initial amount: NaN
is encoded by: hsa:5142
type: Species
name: PDE4B
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
is: Q5TEK5

http://identifiers.org/biomodels.db/MODEL1310110027#_7a57faa3_2c43_412c_b98d_ecc4b83abbf7
is: Q86TM7
name: DPM3
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is encoded by: hsa:54344
has only substance units: false

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_ba8301c5_8bc1_48f4_901c_2535da2ed2d0
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:8898
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: A6NN98
constant: false
name: MTMR2

metaR FAOXC8C6x
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8-->C6)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_767ede32_130b_49c2_88c0_b913a28a03d1
boundary condition: true
name: BCKDHB
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
is: P21953
is encoded by: hsa:594
constant: false

metaR GAPD
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.
modifier: MODEL1310110027#
reactant: MODEL1310110027#
name: glyceraldehyde-3-phosphate dehydrogenase
fast: false
kinetic law: MODEL1310110027#
type: Reaction
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.2.1.12
reversible: true
product: MODEL1310110027#
is: SBO:0000176

metaM val L m
is: CHEBI:16414
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
type: Species
boundary condition: false
is: HMDB00883
initial amount: NaN
constant: false
name: L-valine

metaR PIt8
name: phosphate transport in/out via Na+ symporter
is described by: ECO:0000006
type: Reaction
kinetic law: MODEL1310110027#
is: SBO:0000185
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
reactant: MODEL1310110027#
reversible: true
fast: false
modifier: MODEL1310110027#

metaR r1667
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
reactant: MODEL1310110027#
modifier: MODEL1310110027#
is: SBO:0000185
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
product: MODEL1310110027#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_721a4c0f_dc25_4d73_8019_711baf87a6bc
type: Species
is: Q7GXZ8
initial concentration: NaN
has only substance units: false
name: COX2
is encoded by: hsa:4513
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR G14T16g
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
modifier: MODEL1310110027#
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.4.1.38
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
product: MODEL1310110027#
fast: false
is: SBO:0000176

metaR G14T7g
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
fast: false
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110027#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8704.1) or (8703.1) or (2683.1) or (9334.1) or (8704.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.22

metaR DHCR241r
is version of: http://identifiers.org/ec-code/1.3.1.72
name: 24-dehydrocholesterol reductase [Precursor]
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
fast: false
reversible: false
is: SBO:0000176
product: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110027#_a4a4e25f_9ba1_42ba_a674_9e3d99960ec0
is: Q01959
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6531
type: Species
constant: false
name: SLC6A3
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR DHFtm
product: MODEL1310110027#
type: Reaction
reversible: true
reactant: MODEL1310110027#
fast: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
name: dihydrofolate reversible mitochondrial transport

http://identifiers.org/biomodels.db/MODEL1310110027#_65a27a1c_9295_4ed0_a8e3_21476d84954b
initial amount: NaN
initial concentration: NaN
name: NT5E
constant: false
boundary condition: true
is: SBO:0000252
is: P21589
type: Species
has only substance units: false
is encoded by: hsa:4907

http://identifiers.org/biomodels.db/MODEL1310110027#_133fc4ed_a959_4c04_8fdd_28751acd338b
name: ACAA2
is encoded by: hsa:10449
boundary condition: true
constant: false
has only substance units: false
is: P42765
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR r1018
name: Transport reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
type: Reaction
reactant: MODEL1310110027#
product: MODEL1310110027#
reversible: true
kinetic law: MODEL1310110027#
is: SBO:0000185
is described by: ECO:0000000

metaR EX ins LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Inosine exchange
type: Reaction

metaM CE5236 n
name: O2'-4a-cyclic-tetrahydrobiopterin
has only substance units: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28002
is: SBO:0000247
boundary condition: false
is: HMDB03952
type: Species
constant: false

metaR DGK1
is: SBO:0000176
name: deoxyguanylate kinase (dGMP:ATP)
reversible: true
kinetic law: MODEL1310110027#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
reactant: MODEL1310110027#
product: MODEL1310110027#
modifier: MODEL1310110027#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.8

metaR MTHFDm
reversible: true
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
kinetic law: MODEL1310110027#
is described by: ECO:0000269
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/6.3.4.3
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.5.4.9

metaR LPCOXp
type: Reaction
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000269
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.5.3.1
reversible: false
is: SBO:0000176
name: L-pipecolate oxidase, peroxisomal
fast: false
notes: GENE_ASSOCIATION: (51268.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.3.7 Confidence Level: 4 AUTHORS: PMID:10772957 NOTES:

metaR ORNt4m
product: MODEL1310110027#
type: Reaction
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
reversible: true
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
fast: false
is described by: ECO:0000269
is: SBO:0000185
name: ornithine mitochondrial transport exchange with citruline

metaR EX dgsn LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyguanosine
type: Reaction

metaM inost c
initial amount: NaN
has only substance units: false
name: myo-inositol
is: CHEBI:17268
is: HMDB00211
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
type: Species
constant: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_509bc481_b5d3_4030_8369_a1360ef38159
is encoded by: hsa:5151
boundary condition: true
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: PDE8A

http://identifiers.org/biomodels.db/MODEL1310110027#_1f20553f_10aa_4010_9ee4_b4c0d34f751b
initial concentration: NaN
name: DLAT
is: Q86YI5
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1737
type: Species
boundary condition: true
constant: false

metaM pmtcoa m
is: SBO:0000247
constant: false
is: C00154
has only substance units: false
is: HMDB01338
type: Species
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
is: CHEBI:57379
initial amount: NaN
initial concentration: 1.0
name: Palmitoyl-CoA (n-C16:0CoA)
boundary condition: false

metaR FADH2tru
product: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#
fast: false
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
reactant: MODEL1310110027#
is described by: ECO:0000000
name: FADH2 transporter, endoplasmic reticulum

http://identifiers.org/biomodels.db/MODEL1310110027#_5a99ceee_954f_427d_ac73_d20a0ab2ab9d
is: Q53Y41
is encoded by: hsa:1644
initial concentration: NaN
initial amount: NaN
constant: false
name: DDC
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_0ab78b91_07b7_454d_884f_5fb71cddef64
is: Q6P4B4
boundary condition: true
is encoded by: hsa:5198
is: SBO:0000252
initial concentration: NaN
constant: false
name: PFAS
type: Species
initial amount: NaN
has only substance units: false

metaR FAOXC185C164m
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:5-->C16:4)m
type: Reaction

metaR HMGCOAtm
type: Reaction
reversible: true
kinetic law: MODEL1310110027#
is: SBO:0000185
product: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:NCD
name: Hydroxymethylglutaryl-CoA reversible mitochondrial transport
fast: false
is described by: ECO:0000000

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

metaM 4abutn c
is: SBO:0000247
has only substance units: false
is: CHEBI:58264
initial concentration: 1.0
notes: FORMULA: C4H10NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
is: C00555
constant: false
initial amount: NaN
name: 4-Aminobutanal
boundary condition: false
is: HMDB01080
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_5a7df210_1b53_4a13_873a_ea32db2aaddd
type: Species
initial amount: NaN
name: PAFAH2
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: Q99487
is encoded by: hsa:5051

metaM 3ohdcoa x
type: Species
is: SBO:0000247
constant: false
name: 3-oxopalmitoyl-CoA(4-)
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
is: CHEBI:57349
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB06402
has only substance units: false

metaM 2ddecdicoa m
has only substance units: false
is: HMDB11123
is: C05279
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
type: Species
boundary condition: false
constant: false
initial amount: NaN
name: 2,6-dodecadienoylcoa

metaR DITPtn
reactant: MODEL1310110027#
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
name: dITP nuclear transport
product: MODEL1310110027#
kinetic law: MODEL1310110027#
fast: false

metaM dgsn c
is: CHEBI:17172
is: SBO:0000247
is: HMDB00085
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
is: C00330
initial concentration: 1.0
constant: false
name: Deoxyguanosine
has only substance units: false
type: Species

metaR DM ethamp r
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

metaR RE1526M
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
modifier: MODEL1310110027#
name: RE1526
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110027#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110027#
type: Reaction
fast: false
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR r1665
name: Y+LAT2 Utilized transport
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
product: MODEL1310110027#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110027#_b33d1902_5521_4d4e_ab1b_f4ec3d0f5b0d
name: DGKD
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:8527

http://identifiers.org/biomodels.db/MODEL1310110027#_4e1bffa7_0780_494a_98d4_37a7b2354e30
is: P31040
boundary condition: true
is encoded by: hsa:6389
is: SBO:0000252
name: SDHA
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
type: Species

metaM fum c
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:29806
name: Fumarate
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
is: C00122
is: HMDB00134

metaM C02470 c
is: C02470
name: Xanthurenic acid
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
type: Species
is: http://identifiers.org/pubchem.compound/5485
initial concentration: 1.0
boundary condition: false
is: HMDB00881
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false

metaR CYTK8n
reactant: MODEL1310110027#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110027#
product: MODEL1310110027#
name: cytidylate kinase (CMP,dATP),nuclear
fast: false
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
modifier: MODEL1310110027#

metaM co c
is: CHEBI:17245
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
is: HMDB01361
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
has only substance units: false
name: carbon monoxide
boundary condition: false
initial amount: NaN

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_747efe99_9f2f_41f2_adb5_f04857ee9fc6
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
name: DGKG
boundary condition: true
type: Species
is encoded by: hsa:1608
initial amount: NaN
is: P49619

metaM glutcoa m
has only substance units: false
constant: false
is: HMDB01339
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
is: CHEBI:57378
type: Species
initial amount: NaN
name: glutaryl-CoA(5-)
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110027#_0ddcf12c_1c1e_4c7b_8655_c69150009015
is encoded by: hsa:1836
boundary condition: true
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: P50443
initial amount: NaN
name: SLC26A2

metaR r0130
type: Reaction
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
is: SBO:0000176
reactant: MODEL1310110027#
fast: false
kinetic law: MODEL1310110027#
is described by: ECO:0000000
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
product: MODEL1310110027#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110027#_dac64d3d_dbb3_412b_b1b0_8c26a72734be
is encoded by: hsa:376497
is: SBO:0000252
name: SLC27A1
constant: false
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR ENGASEly
type: Reaction
name: endo-beta-N-acetylglucosaminidase, lysosomal
kinetic law: MODEL1310110027#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110027#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110027#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110027#_8d178f5f_0537_46de_bbac_ea28801a8cbe
is: SBO:0000252
is: Q16348
has only substance units: false
initial amount: NaN
type: Species
constant: false
boundary condition: true
initial concentration: NaN
name: SLC15A2
is encoded by: hsa:6565

metaR r1666
is described by: ECO:0000000
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
fast: false
reversible: true
product: MODEL1310110027#
modifier: MODEL1310110027#
name: Y+LAT2 Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaM aacoa x
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
name: acetoacetyl-CoA(4-)
is: CHEBI:57286
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB01484

metaR S2L2N2M2MASNtly
reactant: MODEL1310110027#
reversible: false
fast: false
is: SBO:0000185
kinetic law: MODEL1310110027#
name: s2l2n2m2masn transport, extracellular to lysosome
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110027#
is described by: ECO:0000000

metaM HC02175 c
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
name: caprate
constant: false
boundary condition: false
is: CHEBI:27689
is: SBO:0000247

metaM HC02208 e
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
has only substance units: false
type: Species
is: CHEBI:27696
initial concentration: 1.0
name: prostaglandin-d1
boundary condition: false

metaR RE0691C
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
is described by: ECO:0000000
name: RE0691
fast: false
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
reversible: true
is: SBO:0000176
type: Reaction
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_20f0fe09_73e2_4ee4_bf49_41b889a30d59
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:FLJ44968
initial concentration: NaN
initial amount: NaN
name: _FLJ44968_1_m
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_93cd42ea_b348_41a1_82d4_4f243154d5e5
boundary condition: true
is encoded by: hsa:51
type: Species
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
is: Q15067
name: ACOX1

metaM nrpphr c
initial concentration: 1.0
is: CHEBI:33569
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
has only substance units: false
boundary condition: false
name: Norepinephrine
is: HMDB00216
type: Species
initial amount: NaN
is: SBO:0000247
constant: false

metaM dgsn e
is: CHEBI:17172
type: Species
name: Deoxyguanosine
is: C00330
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
is: HMDB00085
is: SBO:0000247
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110027#_145ab223_de02_4184_85da_573b587edea1
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
name: _NM_013421_1_e
is encoded by: hsa:NM 013421
type: Species
constant: false
initial concentration: NaN

metaR FAOXC181C161m
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:1-->C16:1)m
type: Reaction

metaR ASNTHRNaEx
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
reversible: false
is: SBO:0000185
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-threonine/L-asparagine Na-dependent exchange (Asn-L in)
reactant: MODEL1310110027#
fast: false
is described by: ECO:0000269
type: Reaction

metaR METt4
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958 NOTES:SAB
fast: false
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110027#
reversible: false
reactant: MODEL1310110027#
name: L-methionine transport in via sodium symport
product: MODEL1310110027#
modifier: MODEL1310110027#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110027#_8f45ffce_ce1f_4f26_ab9f_b25ffeb40216
name: PIGK:PIGU:PIGT:GPAA1:PIGS
has part: Q969N2
boundary condition: true
has part: Q9H490
has part: Q92643
is encoded by: hsa:8733
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:128869
type: Species
initial concentration: NaN
has only substance units: false
has part: O43292
is encoded by: hsa:51604
is encoded by: hsa:10026
has part: Q8NBL9
is encoded by: hsa:94005
constant: false

metaM 3decdicoa m
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN
has only substance units: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: SBO:0000247
name: 3,7-decadienoylcoa
constant: false
type: Species

metaM ura e
is: HMDB00300
name: uracil
initial amount: NaN
is: CHEBI:17568
type: Species
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false

metaR UAGDP
reactant: MODEL1310110027#
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
product: MODEL1310110027#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.23
kinetic law: MODEL1310110027#
type: Reaction
fast: false
is described by: ECO:0000269
name: UDP-N-acetylglucosamine diphosphorylase

http://identifiers.org/biomodels.db/MODEL1310110027#_767c14b0_99b9_4112_b6e7_f37dd49148e5
constant: false
is encoded by: hsa:7991
boundary condition: true
initial amount: NaN
name: TUSC3
is: Q13454
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false

metaR r0801
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110027#
reversible: true
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
kinetic law: MODEL1310110027#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
reactant: MODEL1310110027#
modifier: MODEL1310110027#

metaR RE3421R
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
product: MODEL1310110027#
fast: false
reversible: true
kinetic law: MODEL1310110027#
is described by: ECO:0000000
type: Reaction
name: RE3421
reactant: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_c1b6f504_0a91_40dd_9b97_c09e7520bf0b
has only substance units: false
is encoded by: hsa:883
constant: false
initial concentration: NaN
name: CCBL1
is: SBO:0000252
initial amount: NaN
type: Species
is: Q16773
boundary condition: true

metaM srtn c
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB00259
has only substance units: false
name: serotonin(1+)
is: CHEBI:350546
type: Species
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110027#_31e3fc99_2a6f_4e30_91a3_4f324f095b62
name: MYO5B
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4645
constant: false
is: Q9H6Y6

metaR FAOXC185m
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:5)m
type: Reaction

metaM c4crn x
boundary condition: false
name: butyryl carnitine
is: http://identifiers.org/pubchem.compound/213144
initial amount: NaN
is: SBO:0000247
type: Species
is: C02862
notes: FORMULA: C11H21NO4 CHARGE: 0
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB02013

metaM C02470 e
boundary condition: false
has only substance units: false
name: Xanthurenic acid
type: Species
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
is: http://identifiers.org/pubchem.compound/5485
is: HMDB00881
initial amount: NaN
constant: false
is: C02470
initial concentration: 1.0
is: SBO:0000247

metaM mi1345p c
boundary condition: false
is: HMDB01059
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57895
name: 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
constant: false
notes: FORMULA: C6H8O18P4 CHARGE: -8 INCHI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/p-8/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C01272
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_de15e9ad_ac8d_4cb8_b75d_ef6de7d87c32
constant: false
initial concentration: NaN
has only substance units: false
is: O94777
initial amount: NaN
name: DPM2
is encoded by: hsa:8818
is: SBO:0000252
type: Species
boundary condition: true

metaR VD3
type: Reaction
fast: false
reversible: true
product: MODEL1310110027#
reactant: MODEL1310110027#
is: SBO:0000176
kinetic law: MODEL1310110027#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8392061 NOTES:This reaction takes place in skin and needs body temperature based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
name: Vitamin D3 formation

metaR MDHm
is: SBO:0000176
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
reactant: MODEL1310110027#
name: malate dehydrogenase, mitochondrial
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.37
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
reversible: true
is described by: ECO:0000134
fast: false
product: MODEL1310110027#

metaM xolest2 hs e
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: cholesterol ester
type: Species
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
is: SBO:0000247
boundary condition: false
is: CHEBI:17002
constant: false

metaR ACETONEt2m
name: acetone mitochondrial transport via proton symport
product: MODEL1310110027#
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reversible: true
modifier: MODEL1310110027#
fast: false
reactant: MODEL1310110027#

metaR EX succ LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Succinate exchange
type: Reaction

metaM nrpphr e
boundary condition: false
name: Norepinephrine
is: CHEBI:33569
type: Species
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
initial concentration: 1.0
is: HMDB00216

http://identifiers.org/biomodels.db/MODEL1310110027#_c35f2404_ed8b_43ec_a0b6_d809bb8a57f7
name: MGAT2
initial amount: NaN
type: Species
is encoded by: hsa:4247
has only substance units: false
is: Q10469
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR LEUt5m
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000
product: MODEL1310110027#
type: Reaction
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
name: leucine mitochondrial transport

metaR 1PPDCRp
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:MM
fast: false
reactant: MODEL1310110027#
type: Reaction
name: delta1-piperideine-2-carboxylate reductase, perixosomal
is: SBO:0000176
product: MODEL1310110027#
kinetic law: MODEL1310110027#

metaR PGS
reversible: false
fast: false
type: Reaction
modifier: MODEL1310110027#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.99.1
product: MODEL1310110027#
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (5743.1) or (5742.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.14.99.1 Confidence Level: 4 AUTHORS: PMID:14511332,PMID:1907252 NOTES:NJ
name: Prostaglandin G/H synthase
is: SBO:0000176

metaR r0892
name: Facilitated diffusion
modifier: MODEL1310110027#
reactant: MODEL1310110027#
fast: false
is described by: ECO:0000000
product: MODEL1310110027#
kinetic law: MODEL1310110027#
is: SBO:0000185
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.2.27
reversible: true
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110027#_7fd1e618_70a9_404f_9fac_7ef8ca6a1930
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1716
type: Species
initial amount: NaN
is: E5KSL6
name: DGUOK

metaM c10dc c
name: sebacoyl carnitine
type: Species
constant: false
initial amount: NaN
is: C14143
initial concentration: 1.0
boundary condition: false
is: HMDB04047
is: SBO:0000247
notes: FORMULA: C17H30NO6 CHARGE: -1
has only substance units: false

metaR DHFtl
fast: false
product: MODEL1310110027#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110027#
name: dihydrofolate reversible lysosomal transport
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD,IT
kinetic law: MODEL1310110027#

metaM HC02208 c
constant: false
type: Species
name: prostaglandin-d1
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
initial concentration: 1.0
is: CHEBI:27696
has only substance units: false
is: SBO:0000247

metaR r1669
reactant: MODEL1310110027#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
type: Reaction
product: MODEL1310110027#
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#

metaR EX C02470 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Xanthurenic acid exchange
type: Reaction

metaR 3HCO3 NAt
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110027#
name: 3HCO3_NAt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
kinetic law: MODEL1310110027#
is: SBO:0000185
product: MODEL1310110027#
reversible: true
fast: false

metaM msa m
name: 3-oxopropanoate
is: HMDB11111
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:33190
constant: false

metaR DTMPK
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
reactant: MODEL1310110027#
fast: false
name: dTMP kinase
kinetic law: MODEL1310110027#
is: SBO:0000176
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.4.9
is described by: ECO:0000269
product: MODEL1310110027#
type: Reaction

metaR r0780
reactant: MODEL1310110027#
product: MODEL1310110027#
kinetic law: MODEL1310110027#
is: SBO:0000176
reversible: true
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
fast: false
modifier: MODEL1310110027#
type: Reaction

metaR PSSA1 hs
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (9791.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylcholine as substrate NJ
is described by: ECO:0000269
reactant: MODEL1310110027#
name: Phosphatidylserine synthase homo sapiens
reversible: true
product: MODEL1310110027#
is: SBO:0000176
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.8.29

metaR CERT1rt
is: SBO:0000185
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.11.1
name: ceramide transport protein
type: Reaction
product: MODEL1310110027#
is described by: ECO:0000304
reactant: MODEL1310110027#
reversible: true
fast: false

metaR r1019
is: SBO:0000185
kinetic law: MODEL1310110027#
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110027#
product: MODEL1310110027#
name: Postulated transport reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:

metaR AG13T2g
type: Reaction
fast: false
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
kinetic law: MODEL1310110027#
product: MODEL1310110027#
is: SBO:0000176
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110027#

metaR INSTt2r
name: inositol transport in via proton symport
type: Reaction
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
is: SBO:0000185
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
reactant: MODEL1310110027#
reversible: true
product: MODEL1310110027#
fast: false
is described by: ECO:0000269

metaR 2HBO
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.27
is: SBO:0000176
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
is described by: ECO:0000269
name: 2-Hydroxybutyrate:NAD+ oxidoreductase
reversible: true
notes: GENE_ASSOCIATION: (92483.1) or (3948.2) or (55293.1) or (3945.1 and 3939.1) or (3939.1) or (160287.1) or (3945.1) or (3948.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:10108,PMID:21765 NOTES:NCD
product: MODEL1310110027#
modifier: MODEL1310110027#
fast: false

metaM nicrns c
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB06809
initial concentration: 1.0
name: Nicotinate D-ribonucleoside
type: Species
is: CHEBI:58527
notes: FORMULA: C11H13NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01628 EHMN_ABBREVIATION: C05841
constant: false
boundary condition: false

metaM srtn e
initial amount: NaN
has only substance units: false
name: serotonin(1+)
constant: false
is: HMDB00259
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
is: CHEBI:350546

metaM ser L e
constant: false
is: SBO:0000247
is: CHEBI:17115
boundary condition: false
name: L-serine
has only substance units: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
initial amount: NaN
type: Species
is: HMDB00187
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110027#_4b66f74a_aa64_46e1_853e_0d593b23a407
type: Species
is: F5GWR4
has only substance units: false
initial concentration: NaN
is encoded by: hsa:9481
initial amount: NaN
boundary condition: true
name: SLC25A27
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_4a05803f_70b6_4f23_b56e_dee493c35313
is: SBO:0000252
initial amount: NaN
constant: false
name: RRM2
type: Species
is encoded by: hsa:6241
has only substance units: false
initial concentration: NaN
boundary condition: true
is: P31350

metaM pmtcoa r
is: C00154
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
is: HMDB01338
type: Species
name: Palmitoyl-CoA (n-C16:0CoA)
boundary condition: false
is: CHEBI:3454
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110027#_9cff69b9_5ddb_4828_8837_af83978df390
type: Species
name: NDUFB6
constant: false
initial amount: NaN
is encoded by: hsa:4712
is: SBO:0000252
is: O95139
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR GASNASEly
name: glycosylasparaginase, lysosomal
type: Reaction
kinetic law: MODEL1310110027#
fast: false
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/3.5.1.26
product: MODEL1310110027#
reactant: MODEL1310110027#
is: SBO:0000176
is described by: ECO:0000000
reversible: false

metaM ksii core2 pre2 g
is: CHEBI:58053
has only substance units: false
is: C00130
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 2
is: HMDB00175
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C39H63N3O28X CHARGE: -1
type: Species
initial amount: NaN
constant: false

metaM mescoa m
is: C06028
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
has only substance units: false
constant: false
name: Mesaconyl-CoA
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:27969
initial concentration: 1.0
boundary condition: false

metaR EX xolest2 hs LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cholesterol ester (from FULLR2) exchange
type: Reaction

metaR r1799
is described by: ECO:0000000
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
name: Y+LAT2 Utilized transport
is: SBO:0000185
type: Reaction
reversible: false
fast: false
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110027#

metaR CMPACNAtg
reversible: true
reactant: MODEL1310110027#
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
name: CMP-Sia Golgi transport via CMP antiport
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD
type: Reaction
fast: false

metaR NDPK5n
reversible: true
type: Reaction
product: MODEL1310110027#
is: SBO:0000176
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110027#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
fast: false
modifier: MODEL1310110027#
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear

metaR ME2m
is version of: http://identifiers.org/ec-code/1.1.1.38
is version of: http://identifiers.org/ec-code/1.1.1.40
notes: GENE_ASSOCIATION: (4200.1) or (10873.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:IF
fast: false
name: malic enzyme (NADP), mitochondrial
is described by: ECO:0000000
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
reversible: false
modifier: MODEL1310110027#
is: SBO:0000176
product: MODEL1310110027#
type: Reaction

metaM inost e
boundary condition: false
is: HMDB00211
is: CHEBI:17268
name: myo-inositol
type: Species
has only substance units: false
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaM 2mp2coa m
boundary condition: false
name: 2-Methylprop-2-enoyl-CoA
is: CHEBI:27754
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB01011

http://identifiers.org/biomodels.db/MODEL1310110027#_7a8ecf2a_8474_4626_9b00_035333b417e3
boundary condition: true
name: _AL525798_1_c
is encoded by: hsa:AL525798
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN

metaR RPE
reactant: MODEL1310110027#
fast: false
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110027#
type: Reaction
product: MODEL1310110027#
name: ribulose 5-phosphate 3-epimerase
reversible: true
is version of: http://identifiers.org/ec-code/5.1.3.1

metaR MI14Ptn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
product: MODEL1310110027#
reactant: MODEL1310110027#
fast: false
name: inositol 1,4-bisphosphate nuclear transport (diffusion)
kinetic law: MODEL1310110027#
is described by: ECO:0000000
type: Reaction
reversible: true

metaR r2537
reversible: true
fast: false
name: Utilized transport
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110027#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110027#
is described by: ECO:0000000

metaM udp r
name: UDP
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
has only substance units: false
is: HMDB00295
is: CHEBI:58223
type: Species
is: C00015

metaR r2534
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
product: MODEL1310110027#
is: SBO:0000185
fast: false

metaR r1593
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110027#
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110027#

metaR q10h2tc
is: SBO:0000185
name: transport of ubiquinol into cytosol
fast: false
reversible: true
is described by: ECO:0000134
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#

metaR F6Tg
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2530.4) or (2530.1) or (2530.3) or (2530.2) or (2530.5) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.68 Confidence Level: 0 AUTHORS: PMID:14514715 NOTES:NCD
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.4.1.68
kinetic law: MODEL1310110027#
type: Reaction
is: SBO:0000176
reversible: false
name: glycoprotein 6-alpha-L-fucosyltransferase
fast: false
product: MODEL1310110027#
reactant: MODEL1310110027#

metaM pmtcoa c
has only substance units: false
initial amount: NaN
is: HMDB01338
constant: false
is: C00154
boundary condition: false
is: CHEBI:3454
type: Species
name: Palmitoyl-CoA (n-C16:0CoA)
is: SBO:0000247
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
initial concentration: 1.0

metaR EX akg LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Oxoglutarate exchange
type: Reaction

metaM uri c
initial amount: NaN
is: CHEBI:16704
is: C00299
type: Species
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
constant: false
is: SBO:0000247
boundary condition: false
name: Uridine
is: HMDB00296
has only substance units: false
initial concentration: 1.0

metaR S23T4g
is: SBO:0000176
modifier: MODEL1310110027#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.4.99.4
fast: false
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
name: beta-galactoside alpha-2,3-sialyltransferase
product: MODEL1310110027#
reversible: false

metaM val L e
has only substance units: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: HMDB00883
type: Species
is: CHEBI:16414
constant: false
initial amount: NaN
name: L-valine
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaM so4 c
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: sulfate
is: SBO:0000247
constant: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: HMDB01448
is: CHEBI:16189
boundary condition: false

metaR FUM
kinetic law: MODEL1310110027#
product: MODEL1310110027#
type: Reaction
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.2
fast: false
is: SBO:0000176
modifier: MODEL1310110027#
reversible: true
name: fumarase
is described by: ECO:0000000

metaM gthox c
is: HMDB03337
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
has only substance units: false
is: CHEBI:58297
is: C00127
boundary condition: false
initial amount: NaN
type: Species
name: Oxidized glutathione
initial concentration: 1.0
is: SBO:0000247
constant: false

metaM 4ppcys m
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:59458
is: HMDB01117
type: Species
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_6055af00_d6fb_4085_9071_3b07152d3b59
constant: false
initial concentration: NaN
name: SLC25A14
is encoded by: hsa:9016
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true

metaR RPI
name: ribose-5-phosphate isomerase
fast: false
product: MODEL1310110027#
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110027#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/5.3.1.6

http://identifiers.org/biomodels.db/MODEL1310110027#_d74708c7_c6e1_468f_bbc7_bc1f71f5b761
is encoded by: hsa:5141
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
is: P27815
has only substance units: false
boundary condition: true
name: PDE4A

metaR HDD2COAtx
reactant: MODEL1310110027#
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
product: MODEL1310110027#
name: hdd2coa intracellular transport
kinetic law: MODEL1310110027#
is: SBO:0000185
reversible: true

metaM cmpacna c
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: CHEBI:57812
name: CMP-N-acetyl-beta-neuraminate(2-)
is: HMDB01176
initial amount: NaN
is: SBO:0000247
constant: false

metaM aicar e
boundary condition: false
has only substance units: false
is: C04677
initial concentration: 1.0
constant: false
is: CHEBI:58475
type: Species
is: HMDB01517
initial amount: NaN
notes: FORMULA: C9H13N4O8P CHARGE: -2
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_b9c5e296_4b34_4547_bedc_115dc7499e38
constant: false
is: SBO:0000252
name: GCDH
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2639
type: Species
has only substance units: false
boundary condition: true

metaR r1592
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
product: MODEL1310110027#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r0783
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
type: Reaction
reactant: MODEL1310110027#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
modifier: MODEL1310110027#
product: MODEL1310110027#
kinetic law: MODEL1310110027#
is described by: ECO:0000000
fast: false
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72

metaR r1660
modifier: MODEL1310110027#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110027#
product: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110027#
type: Reaction

metaR r2535
is: SBO:0000185
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
product: MODEL1310110027#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110027#_f6db8287_aca7_4acf_babd_8f23efa60a3f
constant: false
name: FASN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: P49327
type: Species
has only substance units: false
is encoded by: hsa:2194

metaM 2dr5p c
is: CHEBI:57651
has only substance units: false
initial amount: NaN
is: HMDB01031
boundary condition: false
constant: false
type: Species
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
is: SBO:0000247
initial concentration: 1.0
name: 2-deoxy-D-ribose 5-phosphate(2-)

metaM ksii core2 deg9 l
initial amount: NaN
is: HMDB00143
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:12936
notes: FORMULA: C30H50N3O20X CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
name: keratan sulfate II (core 2-linked), degradation product 9

metaR SMS
reversible: false
is version of: http://identifiers.org/ec-code/2.7.8.27
fast: false
reactant: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (259230.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14685263 NOTES:NJ
name: Sphingomyelin synthase (homo sapiens)
is described by: ECO:0000269
product: MODEL1310110027#
is: SBO:0000176
modifier: MODEL1310110027#

metaM ser L c
name: L-serine
is: SBO:0000247
initial amount: NaN
is: CHEBI:17115
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
boundary condition: false
is: HMDB00187
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_6c8286b2_20b7_417e_9203_d9bbe9237e64
initial amount: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:270
initial concentration: NaN
is: P23109
name: AMPD1
has only substance units: false

metaR C6CRNtcx
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexanoylcarnitine into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_2af255de_e0a8_4cda_aba8_d17d164330cd
type: Species
name: SLC35A2
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:7355
initial concentration: NaN
initial amount: NaN
is: P78381
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_c18f8095_2756_43ad_847b_ab7e99b99fd8
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
name: _AA081045_1_m
boundary condition: true
is encoded by: hsa:AA081045
has only substance units: false

metaM 4izp c
is: HMDB01014
initial amount: NaN
constant: false
is: CHEBI:57255
has only substance units: false
is: SBO:0000247
name: 4-Imidazolone-5-propanoate
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C6H7N2O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01157 EHMN_ABBREVIATION: C03680

metaM ksi pre8 g
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:28067
type: Species
name: keratan sulfate I biosynthesis, precursor 8
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C115H186N8O88S2X CHARGE: -3

http://identifiers.org/biomodels.db/MODEL1310110027#_9f2cf3c8_7303_4bd7_92e7_6a6415f6b8eb
type: Species
name: _206_1_c
constant: false
is encoded by: hsa:206
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110027#_1b4ab822_e313_4e7c_8119_fc34738a8b85
name: PECR
is encoded by: hsa:55825
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
is: Q9BY49
type: Species
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_ab8663c4_799f_47ca_8739_c13902bf61f0
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:M68895
constant: false
name: _M68895_1_c
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaM o2 e
is: SBO:0000247
name: O2
is: C00007
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial concentration: 1.0
is: CHEBI:15379
boundary condition: false
is: HMDB01377
constant: false

metaR r2532
is: SBO:0000185
product: MODEL1310110027#
is described by: ECO:0000000
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
reversible: true
reactant: MODEL1310110027#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
type: Reaction

metaR CDS
name: phosphatidate cytidylyltransferase
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (1040.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:ER membrane - but on cytosolic surface NJ
modifier: MODEL1310110027#
is: SBO:0000176
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.7.41
fast: false
product: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction

metaM c8dc e
is: HMDB00705
constant: false
name: suberyl carnitine
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C15H26NO6 CHARGE: -1
boundary condition: false

metaM uri e
is: CHEBI:16704
is: C00299
type: Species
constant: false
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
is: SBO:0000247
is: HMDB00296
boundary condition: false
name: Uridine
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR r0784
modifier: MODEL1310110027#
is: SBO:0000176
fast: false
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
product: MODEL1310110027#
is described by: ECO:0000000
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.3.1.38
type: Reaction
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
reactant: MODEL1310110027#
reversible: true

metaM val L c
is: SBO:0000247
is: CHEBI:16414
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
name: L-valine
type: Species
is: HMDB00883
boundary condition: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_2dd98dd7_f2cd_4261_9148_a79da1abd2f4
name: PIGP
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:51227
constant: false
is: P57054
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR r1595
reactant: MODEL1310110027#
reversible: true
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110027#
product: MODEL1310110027#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r1512
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110027#
name: Utilized transport
is described by: ECO:0000000
type: Reaction
reversible: false
is: SBO:0000185
product: MODEL1310110027#
fast: false

metaR DM Ser Thr ly
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser/Thr(ly)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_668f0321_a0d4_4415_a5db_cdee036f59b2
is encoded by: hsa:100287639
is: SBO:0000252
name: _100287639_1_c
constant: false
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN

metaR r0549
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.6.99.3
kinetic law: MODEL1310110027#
type: Reaction
is version of: http://identifiers.org/ec-code/1.6.5.3
fast: false
modifier: MODEL1310110027#
product: MODEL1310110027#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.1.1.17
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
reversible: true
reactant: MODEL1310110027#

metaR UDPACGALtl
kinetic law: MODEL1310110027#
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - there are UDPACGAL-translocators for ER and Golgi, however no info on lysosomal - poor support for this NJ
type: Reaction
is: SBO:0000185
reactant: MODEL1310110027#
fast: false
name: udpacgal intracellular transport
reversible: true
is described by: ECO:0000000

metaR RTOTAL2t
fast: false
name: RTOTAL2 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110027#
product: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#
is: SBO:0000185

metaR KCC2t
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
fast: false
is: SBO:0000185
reversible: true
name: K+-Cl- cotransporter (NH4+)
modifier: MODEL1310110027#
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_fb4752e8_4a04_41f2_879c_f471d434a407
boundary condition: true
is: SBO:0000252
constant: false
name: PANK2
initial concentration: NaN
is encoded by: hsa:80025
has only substance units: false
type: Species
initial amount: NaN

metaR CHOLK
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (1120.2) or (1119.1) or (1120.1) or (1119.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110027#
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.1.32
type: Reaction
is described by: ECO:0000269
fast: false
reversible: false
is: SBO:0000176
name: Choline kinase

metaM oxa m
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
is: HMDB02329
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
name: oxalate(2-)
initial amount: NaN
initial concentration: 1.0
is: CHEBI:30623
type: Species

metaR r1594
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110027#
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110027#
reactant: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_38c88aa3_5c4b_476a_bb6b_f369e4055055
is encoded by: hsa:3945
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
name: LDHB
is: SBO:0000252
is: P07195

http://identifiers.org/biomodels.db/MODEL1310110027#_ca385e53_ec5f_4473_b804_02f46efc08fc
type: Species
constant: false
is: Q16774
boundary condition: true
name: GUK1
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2987

metaR GGH 7DHFe
kinetic law: MODEL1310110027#
fast: false
is: SBO:0000176
modifier: MODEL1310110027#
reactant: MODEL1310110027#
name: Gamma-glutamyl hydrolase (7DHF), extracellular
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is version of: http://identifiers.org/ec-code/3.4.19.9
type: Reaction
reversible: false
is described by: ECO:0000000

metaR r0202
reversible: true
is described by: ECO:0000000
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
fast: false
type: Reaction
product: MODEL1310110027#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110027#_5d849a2c_0e7d_4563_abdd_c37e803212db
initial concentration: NaN
is: Q9Y673
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: ALG5
constant: false
type: Species
boundary condition: true
is encoded by: hsa:29880

http://identifiers.org/biomodels.db/MODEL1310110027#_ab3591a6_5c74_4d75_b13b_2e313a1a38bc
type: Species
name: IDH1
boundary condition: true
is: O75874
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:3417

http://identifiers.org/biomodels.db/MODEL1310110027#_231bb3c2_c153_42ef_bad3_c057f88f94d1
initial concentration: NaN
is: SBO:0000252
is: Q8NFF2
type: Species
name: SLC24A4
has only substance units: false
is encoded by: hsa:123041
constant: false
boundary condition: true
initial amount: NaN

metaM cholate c
initial amount: NaN
boundary condition: false
is: CHEBI:29747
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB00619
name: Cholate
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
has only substance units: false
type: Species

metaM f6p c
type: Species
is: HMDB00124
is: CHEBI:57579
has only substance units: false
is: http://identifiers.org/pubchem.compound/3385
is: SBO:0000247
initial amount: NaN
constant: false
name: D-Fructose 6-phosphate
is: C00085
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110027#_6919495c_5997_4305_aaa9_c3073038b809
type: Species
is: F8WDN9
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: PPA2
is: SBO:0000252
has only substance units: false
is encoded by: hsa:27068
constant: false

metaM HC01522 c
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585
name: Gentisate aldehyde
has only substance units: false
boundary condition: false
is: CHEBI:28508

http://identifiers.org/biomodels.db/MODEL1310110027#_08de372a_80f7_45aa_bf6e_2f3695d589ea
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: HSD3B2
initial concentration: NaN
is encoded by: hsa:3284
is: P26439
boundary condition: true
constant: false

metaM btn e
initial concentration: 1.0
has only substance units: false
is: HMDB00030
boundary condition: false
initial amount: NaN
notes: FORMULA: C10H15N2O3S CHARGE: -1
type: Species
is: SBO:0000247
is: CHEBI:3420
is: C00120
name: Biotin
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_081de12c_8c84_48aa_b35f_5e68ca2847b8
is encoded by: hsa:4830
initial amount: NaN
type: Species
is: SBO:0000252
name: NME1
is: P15531
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110027#_fd01b186_9d97_4139_b5e9_a7cb56918c2c
is: SBO:0000252
name: PECR
is: Q9BY49
initial amount: NaN
constant: false
is encoded by: hsa:55825
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false

metaM CE5236 c
is: HMDB03952
name: O2'-4a-cyclic-tetrahydrobiopterin
is: CHEBI:28002
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
is: SBO:0000247
initial amount: NaN

metaM clpndcoa x
is: HMDB06267
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205476
name: clupanodonyl CoA
type: Species
constant: false
is: C16166
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1

metaM c8dc c
type: Species
is: HMDB00705
initial amount: NaN
initial concentration: 1.0
name: suberyl carnitine
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C15H26NO6 CHARGE: -1
boundary condition: false

metaR CTPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: true
name: CTP diffusion in nucleus
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110027#
product: MODEL1310110027#
kinetic law: MODEL1310110027#
fast: false
is: SBO:0000185

metaM o2 c
has only substance units: false
name: O2
constant: false
is: C00007
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
boundary condition: false
is: CHEBI:15379
is: HMDB01377
is: SBO:0000247

metaM Lpipecol x
notes: FORMULA: C6H11NO2 CHARGE: 0 INCHI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1 EHMN_ABBREVIATION: C00408
is: SBO:0000247
initial amount: NaN
is: CHEBI:30913
name: L-pipecolic acid
has only substance units: false
is: HMDB00716
boundary condition: false
initial concentration: 1.0
type: Species
constant: false

metaM 4abutn m
is: CHEBI:58264
is: HMDB01080
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
name: 4-ammoniobutanal
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247

metaM dgsn m
has only substance units: false
boundary condition: false
is: HMDB00085
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
is: CHEBI:17172
name: Deoxyguanosine
constant: false
type: Species
initial concentration: 1.0
is: C00330
is: SBO:0000247
initial amount: NaN

metaM cmpacna g
constant: false
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: HMDB01176
is: CHEBI:57812
name: CMP-N-acetyl-beta-neuraminate(2-)
boundary condition: false

metaR S6T2g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
reversible: false
reactant: MODEL1310110027#
type: Reaction
modifier: MODEL1310110027#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110027#
kinetic law: MODEL1310110027#

metaM bildglcur e
type: Species
is: SBO:0000247
is: HMDB03325
is: CHEBI:58471
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
name: bis(beta-glucosyluronate)bilirubin
boundary condition: false

metaR DURIt
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
name: deoxyuridine transport via diffusion
is: SBO:0000185
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_2bc599d6_a33a_47fc_9d51_9a34fcfd47a5
is encoded by: hsa:11212
constant: false
boundary condition: true
type: Species
has only substance units: false
name: PROSC
is: O94903
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaR CHSTEROLt2
is described by: ECO:0000000
kinetic law: MODEL1310110027#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
name: cholesterol intracellular transport
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110027#
product: MODEL1310110027#

metaM dhcrm hs c
initial amount: NaN
constant: false
name: dihydroceramide
boundary condition: false
type: Species
is: CHEBI:31488
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaM tdchola c
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
type: Species
boundary condition: false
is: HMDB00951
initial concentration: 1.0
constant: false
has only substance units: false
name: taurochenodeoxycholate
is: CHEBI:9407
initial amount: NaN
is: SBO:0000247

metaR r1378
kinetic law: MODEL1310110027#
is described by: ECO:0000000
reversible: true
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
reactant: MODEL1310110027#
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_1f326c79_ea98_41e3_835d_30d37ad60d61
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: PAFAH1B3
is: SBO:0000252
has only substance units: false
is: Q15102
is encoded by: hsa:5050
type: Species

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

metaR RE2649C
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.3.1.65
fast: false
kinetic law: MODEL1310110027#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.2.2
modifier: MODEL1310110027#
reversible: true
reactant: MODEL1310110027#
is: SBO:0000176
name: RE2649
type: Reaction

metaR r1664
reactant: MODEL1310110027#
name: Y+LAT2 Utilized transport
product: MODEL1310110027#
modifier: MODEL1310110027#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110027#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110027#_49aff7e1_97a7_4c64_88d8_573eb3e30852
initial concentration: NaN
has only substance units: false
is: Q03393
boundary condition: true
name: PTS
is encoded by: hsa:5805
initial amount: NaN
type: Species
is: SBO:0000252
constant: false

metaR RE3566C
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
product: MODEL1310110027#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110027#
is described by: ECO:0000000
kinetic law: MODEL1310110027#
name: RE3566
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110027#_286e60d1_961a_4a79_a253_e69b903c1a21
has only substance units: false
is: Q92643
is encoded by: hsa:10026
constant: false
is: SBO:0000252
boundary condition: true
name: PIGK
type: Species
initial amount: NaN
initial concentration: NaN

metaR r0787
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.1
modifier: MODEL1310110027#
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
product: MODEL1310110027#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110027#
type: Reaction

metaR PGK
is described by: ECO:0000134
is: SBO:0000176
fast: false
name: phosphoglycerate kinase
kinetic law: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (5230.1) or (375056.1) or (5232.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.2.3
reactant: MODEL1310110027#
reversible: true
product: MODEL1310110027#

metaR MALtm
fast: false
type: Reaction
name: malate transport, mitochondrial
modifier: MODEL1310110027#
product: MODEL1310110027#
is: SBO:0000185
reactant: MODEL1310110027#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:IF
kinetic law: MODEL1310110027#

metaM cholate e
has only substance units: false
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB00619
type: Species
initial concentration: 1.0
name: Cholate
initial amount: NaN
is: CHEBI:29747

metaR TXA2tr
is described by: ECO:0000000
product: MODEL1310110027#
fast: false
type: Reaction
name: thromboxane A2 intracellular transport
kinetic law: MODEL1310110027#
reversible: true
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism for transport - known to be secreted from cells - unknown mechanism or pathway, TXA2tr -> TXA2te to get to EC space NJ
is: SBO:0000185

metaR CHSTEROLt1
fast: false
is described by: ECO:0000304
reversible: true
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?
product: MODEL1310110027#
modifier: MODEL1310110027#
type: Reaction
reactant: MODEL1310110027#
name: cholesterol intracellular transport
is: SBO:0000185
kinetic law: MODEL1310110027#

metaR r1829
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110027#
product: MODEL1310110027#
type: Reaction
fast: false
reversible: false
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
is: SBO:0000185
is described by: ECO:0000000
name: Y+LAT2 Utilized transport

metaR r0208
is described by: ECO:0000000
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.4.1.1
product: MODEL1310110027#
fast: false
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction

metaR H2Oter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110027#
product: MODEL1310110027#
fast: false
name: H2O endoplasmic reticulum transport
kinetic law: MODEL1310110027#
type: Reaction
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110027#_8b7d1a40_ed04_4d65_b939_45dc40b53fb0
constant: false
is encoded by: hsa:3032
has only substance units: false
boundary condition: true
name: HADHA:HADHB
is: SBO:0000297
is encoded by: hsa:3030
initial concentration: NaN
type: Species
has part: E9KL44
initial amount: NaN
has part: P55084

metaR r1661
reversible: true
type: Reaction
modifier: MODEL1310110027#
product: MODEL1310110027#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110027#
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110027#

metaR RE3567C
is: SBO:0000176
type: Reaction
name: RE3567
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
product: MODEL1310110027#

metaM gthox e
boundary condition: false
initial concentration: 1.0
is: CHEBI:58297
type: Species
is: HMDB03337
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_e7478dc3_007b_4d75_842e_02803d437b3d
is: SBO:0000252
is encoded by: hsa:7372
constant: false
initial amount: NaN
boundary condition: true
is: A8K5J1
has only substance units: false
name: UMPS
initial concentration: NaN
type: Species

metaM so4 e
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
name: sulfate
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: CHEBI:16189
is: HMDB01448

metaM mn l
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB06535
has only substance units: false
initial concentration: 1.0
constant: false
name: beta-1,4-mannose-N-acetylglucosamine

metaM s2l2n2m2masn e
is: CHEBI:3554
is: C00255
boundary condition: false
notes: FORMULA: C84H135N6O61X CHARGE: -2
initial concentration: 1.0
has only substance units: false
name: de-Fuc form of PA6
constant: false
initial amount: NaN
type: Species
is: HMDB00244
is: SBO:0000247

metaM dump c
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB01409
boundary condition: false
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
name: dUMP
constant: false
is: CHEBI:246422
initial concentration: 1.0
initial amount: NaN
is: C00365

metaR AG13T14g
reactant: MODEL1310110027#
product: MODEL1310110027#
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
reversible: false
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction

metaR r0788
is version of: http://identifiers.org/ec-code/1.14.13.15
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
product: MODEL1310110027#
is described by: ECO:0000000
fast: false
reversible: true
modifier: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
reactant: MODEL1310110027#
is: SBO:0000176

metaM lnlncgcoa r
is: SBO:0000247
is: HMDB06368
constant: false
initial amount: NaN
name: gamma-linolenoyl-CoA(4-)
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:57363

metaR r1591
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110027#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110027#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR DCYTDn
product: MODEL1310110027#
is: SBO:0000176
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:IT
is version of: http://identifiers.org/ec-code/3.5.4.5
name: deoxycytidine deaminase, nuclear
is described by: ECO:0000254
type: Reaction
fast: false
modifier: MODEL1310110027#
reversible: false
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#

metaM bildglcur c
type: Species
is: SBO:0000247
is: HMDB03325
initial concentration: 1.0
is: CHEBI:58471
has only substance units: false
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
constant: false
name: bis(beta-glucosyluronate)bilirubin
initial amount: NaN
boundary condition: false

metaM HC01118 r
boundary condition: false
constant: false
name: presqualene diphosphate(3-)
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:57310

http://identifiers.org/biomodels.db/MODEL1310110027#_bd1ce706_1e2a_4dfe_91db_90d0e459248c
is: SBO:0000252
constant: false
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:6528
initial amount: NaN
is: Q92911
initial concentration: NaN
name: SLC5A5

metaM cholp c
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
name: choline phosphate(1-)
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
is: CHEBI:295975
initial amount: NaN
type: Species

metaM tdchola e
constant: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: taurochenodeoxycholate
is: CHEBI:9407
is: SBO:0000247
is: HMDB00951
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_23cb0779_8961_43be_9d06_e3795fc66a64
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5296
has only substance units: false
initial amount: NaN
name: PIK3R2
is: O00459
constant: false
type: Species
boundary condition: true

metaR r1715
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: Y+LAT2 Utilized transport
type: Reaction
reversible: false
modifier: MODEL1310110027#
product: MODEL1310110027#
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR RE3628M
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/5.3.3.8
fast: false
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110027#
type: Reaction
is: SBO:0000176
product: MODEL1310110027#
modifier: MODEL1310110027#
reversible: true
name: RE3628
is described by: ECO:0000000

metaR r1662
product: MODEL1310110027#
is described by: ECO:0000000
reactant: MODEL1310110027#
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR r0287
is: SBO:0000176
kinetic law: MODEL1310110027#
product: MODEL1310110027#
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
fast: false
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110027#
type: Reaction
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16

metaR EX ncam LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinamide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_122c0bc0_67ad_43ed_950a_38b91384b22f
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:7360
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
name: UGP2
is: Q16851
constant: false

metaR MI1PP
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.1.3.25
is: SBO:0000176
type: Reaction
reversible: false
is described by: ECO:0000269
name: myo-inositol 1-phosphatase
product: MODEL1310110027#
fast: false
reactant: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_b30bd7e3_45b7_4a07_8f40_7cdf64ca5b19
is: Q9GZV3
boundary condition: true
is encoded by: hsa:60482
initial concentration: NaN
initial amount: NaN
type: Species
name: SLC5A7
is: SBO:0000252
has only substance units: false
constant: false

metaM CE2839 e
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5041
constant: false
is: C01936
type: Species
has only substance units: false
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
initial concentration: 1.0
name: maltodecaose

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

metaR PIt7
reversible: true
kinetic law: MODEL1310110027#
name: phosphate transport in/out via three Na+ symporter
product: MODEL1310110027#
type: Reaction
modifier: MODEL1310110027#
is: SBO:0000185
fast: false
reactant: MODEL1310110027#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT

http://identifiers.org/biomodels.db/MODEL1310110027#_1b431edf_c7b4_4ac6_8064_a90140bbef3f
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:4731
name: NDUFV3
is: P56181
constant: false
initial concentration: NaN

metaR r1590
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
product: MODEL1310110027#
is: SBO:0000185

metaR FAOXC122C101m
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:2-->C10:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_c80659da_7f84_4787_9219_e571f349fc43
is: P00338
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:3939
initial amount: NaN
name: LDHA
initial concentration: NaN
boundary condition: true
type: Species

metaM ump c
type: Species
initial amount: NaN
name: UMP
is: C00105
is: SBO:0000247
is: CHEBI:57865
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
constant: false
is: HMDB00288
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR 5MTHFt2le
is: SBO:0000185
is described by: ECO:0000134
product: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
name: 5-methyltetrahydrofolate transport via anion exchange
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110027#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110027#_9bdbe9d1_c31c_4fef_a336_4a41d5318d62
is: SBO:0000252
is encoded by: hsa:221
name: ALDH3B1
is: P43353
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
type: Species

metaR PDE1
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (5139.1) or (5142.1) or (5151.3) or (5153.1) or (5150.2) or (5143.1) or (5150.1) or (5137.1) or (5144.1) or (5136.2) or (5140.2) or (5151.2) or (10846.1) or (5151.5) or (5140.1) or (5141.1) or (5138.1) or (5136.1) or (5151.4) or (5151.1) or (27115.1) or (50940.1) or (8622.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10725373,PMID:10872825,PMID:10906126,PMID:10952971,PMID:11050148,PMID:11114167,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12388353,PMID:12681444,PMID:12764607,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8884271,PMID:9210593,PMID:9419816 NOTES:NCD
product: MODEL1310110027#
reversible: false
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.1.4.17
is version of: http://identifiers.org/ec-code/3.1.4.35
is described by: ECO:0000269
name: 3',5'-cyclic-nucleotide phosphodiesterase
fast: false
type: Reaction
kinetic law: MODEL1310110027#
is: SBO:0000176

metaR PGI
is version of: http://identifiers.org/ec-code/5.3.1.9
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:
name: glucose-6-phosphate isomerase
is described by: ECO:0000134
fast: false
is: SBO:0000176
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
type: Reaction
reversible: true
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_45b495b3_47e4_41a1_9936_4a6c2956a798
name: SLC25A26
type: Species
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:115286
is: Q70HW3
boundary condition: true
is: SBO:0000252

metaR r0789
is: SBO:0000176
reversible: true
product: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110027#
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.15
modifier: MODEL1310110027#
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110027#_d69cb34e_11d1_48b8_892a_2c8660c236f9
name: BCAT2
has only substance units: false
type: Species
boundary condition: true
is: O15382
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:587

http://identifiers.org/biomodels.db/MODEL1310110027#_e72089dd_d521_4ca3_88c2_3a913291f430
is encoded by: hsa:9843
type: Species
initial amount: NaN
is: E9PHN8
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
name: HEPH
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110027#_f201ca49_4910_4403_a610_f94639a0fe62
name: PISD
is: Q9UG56
type: Species
is encoded by: hsa:23761
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110027#_133c1d4d_2a46_4a0e_ae8f_cdd1b408233b
initial amount: NaN
boundary condition: true
constant: false
type: Species
initial concentration: NaN
has only substance units: false
name: _AA502753_1_m
is encoded by: hsa:AA502753
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110027#_d926f613_fda5_421c_9e5f_1bd23407fdbb
type: Species
initial amount: NaN
name: NDUFA6
is: P56556
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4700
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110027#_d711af2f_7620_49bd_a062_a53c050e91ac
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4830
name: NME1
type: Species
is: SBO:0000252
has only substance units: false

metaR GGH 7DHFl
is described by: ECO:0000000
product: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#
fast: false
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is version of: http://identifiers.org/ec-code/3.4.19.9
modifier: MODEL1310110027#
name: Gamma-glutamyl hydrolase (7DHF), lysosomal
reactant: MODEL1310110027#

metaM oxa c
is: SBO:0000247
name: oxalate(2-)
boundary condition: false
type: Species
has only substance units: false
is: HMDB02329
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
initial concentration: 1.0
is: CHEBI:30623
initial amount: NaN
constant: false

metaM lnlncg l
type: Species
initial amount: NaN
name: gamma-linolenate
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB03073
has only substance units: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
is: SBO:0000247
is: CHEBI:32391

metaM man e
name: D-Mannose
type: Species
initial amount: NaN
is: SBO:0000247
is: C00159
boundary condition: false
is: CHEBI:16024
constant: false
initial concentration: 1.0
is: HMDB00169
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159

metaR DOLGLCP Lter
name: Dolichyl beta-D-glucosyl phosphate flippase (liver)
is described by: ECO:0000000
fast: false
product: MODEL1310110027#
type: Reaction
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
reactant: MODEL1310110027#

metaR r0779
kinetic law: MODEL1310110027#
reversible: false
type: Reaction
reactant: MODEL1310110027#
fast: false
is described by: ECO:0000000
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR CHOLtu
is: SBO:0000185
modifier: MODEL1310110027#
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
reactant: MODEL1310110027#
name: Choline uniport
kinetic law: MODEL1310110027#
is described by: ECO:0000269
type: Reaction
fast: false
reversible: true

metaR r2317
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
reactant: MODEL1310110027#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
product: MODEL1310110027#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110027#
fast: false

metaR r1374
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:17267599 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
is: SBO:0000176
product: MODEL1310110027#
name: EC:3.2.1.14
fast: false
reversible: false

metaM lnlccrn m
has only substance units: false
is: HMDB06469
constant: false
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
initial amount: NaN
is: SBO:0000247
name: Linoleyl carnitine
boundary condition: false
type: Species
initial concentration: 1.0

metaR THFtm
is: SBO:0000185
kinetic law: MODEL1310110027#
reversible: true
type: Reaction
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
reactant: MODEL1310110027#
is described by: ECO:0000000
product: MODEL1310110027#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110027#_921acf7e_0e23_44c6_a7dc_a4f48d4faa67
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: PLA2G10
is encoded by: hsa:8399
is: O15496
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110027#_ead55288_00e4_4aae_903e_60190fba1cba
is: C9JT23
has only substance units: false
initial concentration: NaN
name: NDUFA11
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:126328
constant: false
is: SBO:0000252

metaR r0345
modifier: MODEL1310110027#
reactant: MODEL1310110027#
product: MODEL1310110027#
reversible: true
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
is version of: http://identifiers.org/ec-code/1.3.99.13
is described by: ECO:0000000
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.3.99.3
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false

http://identifiers.org/biomodels.db/MODEL1310110027#_db2f7a1b_1e3f_4056_be8b_62688f8e2764
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:9016
constant: false
name: SLC25A14
is: O95258
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110027#_b392d3e9_ce62_4349_9842_9270938aa590
initial concentration: NaN
constant: false
name: ND6
type: Species
is encoded by: hsa:4541
is: Q7GXZ1
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110027#_3abfd457_80cc_4240_a3f6_8e2f4f2b7a7e
has only substance units: false
initial amount: NaN
type: Species
name: UCK2
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:7371
is: Q9BZX2

metaR GLYSARPEPT1tc
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: Transport of Glycylsarcosine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine, renal cells and brain.
type: Reaction

metaM leuktrC4 e
is: SBO:0000247
initial concentration: 1.0
is: HMDB01198
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
constant: false
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
name: leukotriene C4(2-)
is: CHEBI:57973

http://identifiers.org/biomodels.db/MODEL1310110027#_866af78d_9707_4b35_8457_082ab281d8e1
is: P36021
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:6567
initial amount: NaN
constant: false
name: SLC16A2

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

metaM hdca l
has only substance units: false
name: palmitate
type: Species
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: HMDB00220
is: CHEBI:7896
initial concentration: 1.0
initial amount: NaN

metaR RE2659R
name: RE2659
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
reversible: true
reactant: MODEL1310110027#
is described by: ECO:0000000
fast: false
is: SBO:0000176
product: MODEL1310110027#
kinetic law: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_a7964094_64e4_45b1_9430_db1e19a7d4b1
initial amount: NaN
boundary condition: true
is: Q86SF2
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:51809
name: GALNT7

metaR r2316
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
reversible: true
reactant: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
product: MODEL1310110027#
is described by: ECO:0000000
kinetic law: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_cc274408_07d3_4220_a32f_48d5ddb32762
initial amount: NaN
has only substance units: false
is: B7Z5T8
is encoded by: hsa:1375
constant: false
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: CPT1B

http://identifiers.org/biomodels.db/MODEL1310110027#_1a8987bc_70cf_4e9b_8305_e013cbdb884d
initial amount: NaN
name: GPX3
is: P22352
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:2878
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110027#_e860f826_ee6a_493a_aabd_f15c0466e7c3
has only substance units: false
initial amount: NaN
name: COX3
is encoded by: hsa:4514
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: P00414

metaR URIt
fast: false
reactant: MODEL1310110027#
type: Reaction
modifier: MODEL1310110027#
is: SBO:0000185
kinetic law: MODEL1310110027#
name: uridine facilated transport in cytosol
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_1af97d9a_7c9b_4265_bcf5_6a15f67b3db8
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: VNN3:VNN2:VNN1
type: Species
is encoded by: hsa:55350
is: SBO:0000297
constant: false

metaR r0660
is described by: ECO:0000000
kinetic law: MODEL1310110027#
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.2
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
fast: false
modifier: MODEL1310110027#
type: Reaction
reactant: MODEL1310110027#
is: SBO:0000176
product: MODEL1310110027#
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17

metaM c4crn c
is: HMDB02013
initial amount: NaN
is: http://identifiers.org/pubchem.compound/213144
is: SBO:0000247
boundary condition: false
type: Species
is: C02862
constant: false
has only substance units: false
notes: FORMULA: C11H21NO4 CHARGE: 0
initial concentration: 1.0
name: butyryl carnitine

metaR r1375
fast: false
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:17267599 NOTES:
product: MODEL1310110027#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110027#
name: Transport reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_c6fee3aa_ad9f_44bd_a48e_5f3f03e74819
constant: false
is encoded by: hsa:55811
is: SBO:0000252
name: ADCY10
is: F5GWS5
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true

metaM 4ppcys c
is: CHEBI:59458
type: Species
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
is: C04352
is: HMDB01117
constant: false
has only substance units: false

metaM CE4790 m
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
has only substance units: false
is: CHEBI:57923
boundary condition: false
initial concentration: 1.0

metaM cytd n
is: SBO:0000247
initial amount: NaN
is: CHEBI:17562
has only substance units: false
notes: FORMULA: C9H13N3O5 CHARGE: 0 INCHI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
boundary condition: false
constant: false
name: cytidine
initial concentration: 1.0
is: HMDB00089
type: Species

metaM gthrd m
initial amount: NaN
is: CHEBI:57925
is: HMDB00125
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
constant: false
has only substance units: false
name: glutathionate(1-)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_7ae79327_0463_444e_b108_5953d8f73be8
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:60386
name: SLC25A19
type: Species
is: SBO:0000252
constant: false
is: Q9HC21

metaM udp l
boundary condition: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
has only substance units: false
is: SBO:0000247
is: CHEBI:58223
is: HMDB00295
type: Species
initial concentration: 1.0
constant: false
name: UDP(3-)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_d659fea1_b9c1_447e_962e_1c37ef4c78a5
is: SBO:0000252
constant: false
initial concentration: NaN
name: HAS1
is encoded by: hsa:3036
initial amount: NaN
has only substance units: false
is: Q8IYH3
boundary condition: true
type: Species

metaM rbt c
is: HMDB00508
boundary condition: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
initial amount: NaN
initial concentration: 1.0
name: D-ribitol
constant: false
is: CHEBI:15963
has only substance units: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_ed32225b_3202_454f_99a7_324a14165431
is: Q86WA9
name: SLC26A11
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:284129
initial amount: NaN
constant: false
type: Species

metaM biliverd c
is: HMDB01008
constant: false
initial amount: NaN
is: CHEBI:57991
name: biliverdin(2-)
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C33H32N4O6 CHARGE: -2 INCHI: InChI=1S/C33H34N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-15,35H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14-,28-15- EHMN_ABBREVIATION: C00500
is: SBO:0000247

metaM oxa e
is: HMDB02329
type: Species
boundary condition: false
name: oxalate(2-)
has only substance units: false
is: CHEBI:30623
initial amount: NaN
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
initial concentration: 1.0
constant: false
is: SBO:0000247

metaM man c
is: HMDB00169
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
name: D-Mannose
is: C00159
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
type: Species
is: CHEBI:16024
is: SBO:0000247
boundary condition: false

metaR SO4tl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
fast: false
reactant: MODEL1310110027#
is described by: ECO:0000269
reversible: true
name: Sulfate transport (lysosome)
product: MODEL1310110027#
is: SBO:0000185
kinetic law: MODEL1310110027#
type: Reaction

metaR r2315
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false

metaR r0552
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.5.1
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110027#
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
modifier: MODEL1310110027#
reactant: MODEL1310110027#
type: Reaction
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8

http://identifiers.org/biomodels.db/MODEL1310110027#_1fed10c8_78b3_4db3_8f7f_b284fc01fbb7
boundary condition: true
is: SBO:0000252
name: HSD3B7
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:80270
is: Q9H2F3
type: Species
constant: false
has only substance units: false

metaR r0456
type: Reaction
is: SBO:0000176
reactant: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.32
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
product: MODEL1310110027#
modifier: MODEL1310110027#
reversible: false
kinetic law: MODEL1310110027#

metaR C6DCe
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of adipoyl carnitine into the extra cellular fluid
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_ccbe3c74_b237_4da7_a31d_f4e74dbe3254
is: Q6IBC4
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:4726
initial concentration: NaN
type: Species
name: NDUFS6
has only substance units: false

metaM cholp g
has only substance units: false
is: CHEBI:295975
initial concentration: 1.0
is: C00588
type: Species
boundary condition: false
name: choline phosphate(1-)
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588

http://identifiers.org/biomodels.db/MODEL1310110027#_fc85814b_5613_4f3d_8ad0_456fb37ee708
is encoded by: hsa:278
is: P04745
is: SBO:0000252
type: Species
constant: false
has only substance units: false
name: AMY1C
boundary condition: true
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_0098fe4a_9e69_4dfe_a511_d8f92a41e777
type: Species
has only substance units: false
is encoded by: hsa:285973
is: Q674R7
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: ATG9B
is: SBO:0000252
constant: false

metaR EX gthox LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Oxidized glutathione exchange
type: Reaction

metaM udpacgal c
initial amount: NaN
constant: false
name: UDP-N-acetyl-D-galactosamine(2-)
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: HMDB00304
is: CHEBI:57847
boundary condition: false
is: SBO:0000247

metaR HAS1
type: Reaction
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.4.1.212
name: hyaluronan synthase
fast: false
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110027#_8ba81b73_d90b_4b6b_b0ac_37fe2dcd4467
initial amount: NaN
is encoded by: hsa:1632
has only substance units: false
type: Species
constant: false
name: ECI1
is: P42126
is: SBO:0000252
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_ef9ba252_83f0_49f3_81eb_4ad6373f68df
name: UCK1
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: Q5JT09
is encoded by: hsa:83549
initial amount: NaN
constant: false

metaR THYOXt
reversible: true
modifier: MODEL1310110027#
is: SBO:0000185
reactant: MODEL1310110027#
fast: false
is described by: ECO:0000269
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (53919.1) or (6579.1) or (28231.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
kinetic law: MODEL1310110027#
type: Reaction
name: T4 transport via bicarbonate countertransport

metaM ksi pre2 g
is: SBO:0000247
initial concentration: 1.0
is: HMDB00175
type: Species
notes: FORMULA: C87H142N6O62X CHARGE: -1
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 2
is: C00130
constant: false

metaM ksii core4 e
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
name: keratan sulfate II (core 4-linked)
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:17268
is: HMDB00211
type: Species
boundary condition: false
initial amount: NaN
constant: false

metaR r2314
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110027#
fast: false
product: MODEL1310110027#
reactant: MODEL1310110027#
type: Reaction

metaR DNDPt10m
is described by: ECO:0000269
product: MODEL1310110027#
reactant: MODEL1310110027#
name: dADP transport via dCDP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
modifier: MODEL1310110027#
is: SBO:0000185
kinetic law: MODEL1310110027#
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110027#_c68eb0c6_f6a9_44e9_9201_4bc690458286
initial concentration: NaN
is: SBO:0000252
is: Q6IBC0
constant: false
has only substance units: false
name: HMGCL
boundary condition: true
is encoded by: hsa:3155
initial amount: NaN
type: Species

metaR r1377
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110027#
reversible: true
type: Reaction
is: SBO:0000176
product: MODEL1310110027#
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
kinetic law: MODEL1310110027#

metaM prgstrn c
is: HMDB01830
constant: false
has only substance units: false
name: progesterone
is: SBO:0000247
type: Species
notes: FORMULA: C21H30O2 CHARGE: 0 INCHI: InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C00410
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17026

metaR GLUt7l
kinetic law: MODEL1310110027#
fast: false
is described by: ECO:0000000
product: MODEL1310110027#
reversible: false
reactant: MODEL1310110027#
name: Glutamate transport, lysosomal
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:IT

metaR r0553
is described by: ECO:0000000
kinetic law: MODEL1310110027#
product: MODEL1310110027#
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
fast: false
type: Reaction
is: SBO:0000176
reversible: true

metaR TYRCBOX
reversible: false
product: MODEL1310110027#
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.28
is: SBO:0000176
reactant: MODEL1310110027#
modifier: MODEL1310110027#
name: L-Tyrosine carboxy-lyase
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
type: Reaction
kinetic law: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_526b2509_4128_4012_b3b8_22d31cbe5b6d
is: SBO:0000252
is encoded by: hsa:7001
name: PRDX2
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_a34ff11f_b2b8_4aac_9020_48b1f5664131
name: AMPD2
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:271
is: E9PNG0
boundary condition: true
constant: false
type: Species

metaR DOPASULT
is described by: ECO:0000269
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/2005)
is: SBO:0000176
modifier: MODEL1310110027#
reversible: false
is version of: http://identifiers.org/ec-code/2.8.2.1
type: Reaction
fast: false
name: Dopamine Sulfotransferase
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_5dc42876_d260_489a_9893_9223eed035fc
constant: false
is: Q6IA69
type: Species
name: NADSYN1
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:55191
is: SBO:0000252
initial concentration: NaN

metaR LNLCCPT1
reactant: MODEL1310110027#
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110027#
fast: false
modifier: MODEL1310110027#
name: carnitine O-palmitoyltransferase
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_f030ef10_cf0b_4ca9_91f2_6389f90706ff
has only substance units: false
has part: P57054
is encoded by: hsa:51227
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:9091
is encoded by: hsa:5277
has part: B2RAU6
is encoded by: hsa:5279
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
boundary condition: true
is: SBO:0000297
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_6423daf7_ddc9_4035_b5f3_878661061f0e
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:84720
boundary condition: true
has only substance units: false
is: Q8TEQ8
name: PIGO
type: Species

metaR LYStiDF
modifier: MODEL1310110027#
fast: false
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (6541.1) or (6542.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
is described by: ECO:0000269
kinetic law: MODEL1310110027#
is: SBO:0000185
type: Reaction
name: L-lysine transport via diffusion (extracellular to cytosol)
reversible: false
product: MODEL1310110027#

metaM docohepcoa m
has only substance units: false
is: HMDB02288
constant: false
notes: FORMULA: C43H60N7O17P3S CHARGE: -4
type: Species
initial amount: NaN
name: 2,4,7,10,13,16,19-docosaheptenoylcoa
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaR r0558
kinetic law: MODEL1310110027#
product: MODEL1310110027#
fast: false
reactant: MODEL1310110027#
is described by: ECO:0000000
reversible: true
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
type: Reaction
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.3
modifier: MODEL1310110027#
is: SBO:0000176

metaR 7DHFtl
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:carrier-mediated transport - but which and how is unknown IT
kinetic law: MODEL1310110027#
name: 7-glutamyl-DHF transport, lysosomal
is described by: ECO:0000000
reactant: MODEL1310110027#
product: MODEL1310110027#
fast: false
reversible: false
is: SBO:0000185

metaR r1446
kinetic law: MODEL1310110027#
reversible: false
is: SBO:0000176
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
product: MODEL1310110027#
is described by: ECO:0000000
name: EC:1.3.3.6
type: Reaction
fast: false

metaR r1596
reactant: MODEL1310110027#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110027#
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_bf386693_57c2_4760_90fd_eec843b977b4
is encoded by: hsa:9415
has only substance units: false
boundary condition: true
name: FADS2
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: O95864
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_8868ac29_3c68_4334_911a_2421a4b93ed5
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: Q13946
name: PDE7A
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:5150
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_7061056f_84b0_4af2_989e_1bc8454fd72e
is: Q9NWU1
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:54995
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: OXSM

metaR r2313
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
product: MODEL1310110027#
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR 5ADTSTSTERONESte
fast: false
type: Reaction
product: MODEL1310110027#
name: sulfonated testosterone transport
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
reversible: true
reactant: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_d59b768a_1257_4cac_a4cd_f1f3447ad3ae
is: H0UI06
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1347
has only substance units: false
name: COX7A2
type: Species
constant: false
boundary condition: true
is: SBO:0000252

metaM pacald c
is: CHEBI:16424
is: HMDB06236
constant: false
initial amount: NaN
has only substance units: false
name: phenylacetaldehyde
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110027#_67bf132d_a786_42bd_83ca_f2ef712cd81e
is: SBO:0000252
has only substance units: false
constant: false
type: Species
name: ACAD8
initial amount: NaN
is encoded by: hsa:27034
initial concentration: NaN
boundary condition: true
is: Q6ZWP6

metaM ksii core4 g
boundary condition: false
name: keratan sulfate II (core 4-linked)
is: SBO:0000247
is: HMDB01014
has only substance units: false
is: CHEBI:57255
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C89H142N7O72S3X CHARGE: -4

metaM glyc c
is: HMDB00131
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
name: Glycerol
is: C00116
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:17754

metaR LNLCCPT2
type: Reaction
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110027#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110027#
name: carnitine transferase
reversible: false
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110027#

metaR FAOXC10DCC8DCx
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10DC-->C8DC)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_b76b7f91_3243_421a_b587_096296badd8b
is encoded by: hsa:7358
boundary condition: true
type: Species
constant: false
initial amount: NaN
is: O60701
has only substance units: false
is: SBO:0000252
name: UGDH
initial concentration: NaN

metaM pram c
is: HMDB01128
is: CHEBI:58681
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: C03090
boundary condition: false
constant: false
notes: FORMULA: C5H11NO7P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01053 EHMN_ABBREVIATION: C03090
initial amount: NaN
name: 5-Phospho-beta-D-ribosylamine

metaM leu L c
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:15603
constant: false
name: L-leucine
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: HMDB00687
initial concentration: 1.0

metaR r0559
reversible: true
modifier: MODEL1310110027#
type: Reaction
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.3
fast: false
is: SBO:0000176
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110027#_c8db2b5d_6a7a_47da_905b_8393d020cf4d
constant: false
initial amount: NaN
is encoded by: hsa:124935
has only substance units: false
type: Species
initial concentration: NaN
is: Q8N370
boundary condition: true
is: SBO:0000252
name: SLC43A2

metaR NRPPHRtu
name: Norepinephrine uniport
reversible: true
modifier: MODEL1310110027#
is: SBO:0000185
type: Reaction
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
fast: false
is described by: ECO:0000269
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#

metaR 5ADTSTSTERONEte
reactant: MODEL1310110027#
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reversible: true
product: MODEL1310110027#
kinetic law: MODEL1310110027#
name: 5 alpha dihydrotesterone transport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110027#_3f41632a_25b9_44f9_be2c_c9bee76eb904
name: GART
has only substance units: false
is encoded by: hsa:2618
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is: P22102

metaR r1597
kinetic law: MODEL1310110027#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110027#
product: MODEL1310110027#
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM 10fthf5glu e
notes: FORMULA: C40H45N11O19 CHARGE: -6
is: CHEBI:16236
has only substance units: false
type: Species
is: SBO:0000247
constant: false
is: HMDB00108
name: 10-formyltetrahydrofolate-[Glu](5)
boundary condition: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_56e5fd8d_3d4f_4d4b_bc0c_f8d3cbef1aff
constant: false
name: B3GNT1
initial concentration: NaN
boundary condition: true
is encoded by: hsa:11041
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: O43505
type: Species

metaM ocdca c
name: stearate
is: CHEBI:25629
is: HMDB00827
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
type: Species
constant: false

metaM udp n
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
type: Species
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:58223
boundary condition: false
is: HMDB00295
name: UDP(3-)
initial concentration: 1.0
initial amount: NaN

metaR r0340
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.3.1.38
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110027#
product: MODEL1310110027#
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110027#_7b4298fa_e3e1_4943_bc22_e6185d678fdc
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:93183
name: PIGM
constant: false
is: Q9H3S5
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species

metaR r2312
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
is: SBO:0000185
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
product: MODEL1310110027#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is described by: ECO:0000000

metaR DURItn
reactant: MODEL1310110027#
is: SBO:0000185
name: deoxyuridine transport in nucleus
kinetic law: MODEL1310110027#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110027#
fast: false
is described by: ECO:0000000

metaM man g
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: SBO:0000247
constant: false
is: CHEBI:16024
boundary condition: false
name: D-mannose
initial concentration: 1.0
is: HMDB00169
type: Species
has only substance units: false
initial amount: NaN

metaM ksii core2 pre9 g
is: CHEBI:28067
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 9
notes: FORMULA: C75H120N6O59S2X CHARGE: -3
boundary condition: false
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_d508540b_8750_4b69_9671_f74a44ac7eb3
initial amount: NaN
initial concentration: NaN
name: _NM_013421_1_m
is: SBO:0000252
has only substance units: false
is encoded by: hsa:NM 013421
type: Species
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110027#_0f6447b1_ad9a_4210_a3e7_57838182e716
boundary condition: true
name: PANK1
is encoded by: hsa:53354
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_40705df3_cb64_4da8_b3c8_b71744162c80
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:5743
is: P35354
initial amount: NaN
initial concentration: NaN
type: Species
name: PTGS2
is: SBO:0000252

metaR Asn X Ser Thrtr
is: SBO:0000185
name: Asn-X-Ser/Thr transport (from ER to lysosome)
type: Reaction
fast: false
is described by: ECO:0000269
reactant: MODEL1310110027#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:10823827,PMID:12845534 NOTES:
product: MODEL1310110027#
kinetic law: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_eab75447_465f_45ca_b95c_4e8980139b92
is: P22392
constant: false
is encoded by: hsa:4831
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: NME2
boundary condition: true

metaM gthox m
is: CHEBI:58297
has only substance units: false
boundary condition: false
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
is: HMDB03337
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
constant: false

metaR CGLYt3 2
reversible: false
product: MODEL1310110027#
name: Cys-Gly transport in via proton symport
kinetic law: MODEL1310110027#
is: SBO:0000185
fast: false
modifier: MODEL1310110027#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB
reactant: MODEL1310110027#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_ca439741_4ff8_4de5_988b_f0fa7e7cc051
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: Q96AT9
boundary condition: true
type: Species
is encoded by: hsa:6120
name: RPE

http://identifiers.org/biomodels.db/MODEL1310110027#_ba713989_36a6_4913_a73f_e03c7ae6ff21
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:200010
boundary condition: true
is: E9PAK4
name: SLC5A9
initial concentration: NaN
constant: false
type: Species

metaR ACHEe
product: MODEL1310110027#
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.1.1.7
is described by: ECO:0000269
is: SBO:0000176
reversible: false
modifier: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES:NJ
type: Reaction
name: Acetylcholinesterase

metaM leu L e
is: CHEBI:15603
is: HMDB00687
initial amount: NaN
boundary condition: false
constant: false
type: Species
name: L-leucine
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: SBO:0000247

metaR r1598
product: MODEL1310110027#
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110027#
reversible: true
reactant: MODEL1310110027#

metaR r0556
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
is: SBO:0000176
modifier: MODEL1310110027#
is described by: ECO:0000000
product: MODEL1310110027#
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.14.19.1
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110027#_600b1b99_c00f_4a36_b681_728be5f7f0e4
type: Species
name: AKR1A1
initial concentration: NaN
constant: false
is: P14550
has only substance units: false
is encoded by: hsa:10327
is: SBO:0000252
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110027#_79833dcc_9650_414c_a62c_fee197927fbe
has part: P22392
has part: P15531
name: NME1:NME2
boundary condition: true
is encoded by: hsa:4830
is: SBO:0000297
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:4831

metaR r2311
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
kinetic law: MODEL1310110027#
reversible: true
product: MODEL1310110027#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110027#
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185

metaM s2l2n2m2masn l
boundary condition: false
name: de-Fuc form of PA6
has only substance units: false
initial amount: NaN
is: CHEBI:18287
is: SBO:0000247
constant: false
notes: FORMULA: C84H135N6O61X CHARGE: -2
is: HMDB00174
type: Species
initial concentration: 1.0

metaM lnlncg e
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
name: gamma-linolenate
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:32391
is: SBO:0000247
is: HMDB03073
initial concentration: 1.0
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_6fd71358_2079_4b90_8f7e_6884c1f48490
is: SBO:0000252
is encoded by: hsa:2678
boundary condition: true
constant: false
name: GGT1
type: Species
initial concentration: NaN
is: P19440
initial amount: NaN
has only substance units: false

metaM andrstndn r
has only substance units: false
constant: false
is: SBO:0000247
type: Species
name: androst-4-ene-3,17-dione
notes: FORMULA: C19H26O2 CHARGE: 0 INCHI: InChI=1S/C19H26O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-16H,3-10H2,1-2H3/t14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00280
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16422
is: HMDB00053

http://identifiers.org/biomodels.db/MODEL1310110027#_40d041a8_6dc6_4750_90e7_b6e0a8dc3481
has only substance units: false
is encoded by: hsa:AI373818
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
name: _AI373818_1_m

metaM glyc e
is: SBO:0000247
constant: false
initial amount: NaN
is: C00116
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
name: Glycerol
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB00131
is: CHEBI:17754
boundary condition: false

metaM aicar c
is: HMDB01517
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
constant: false
initial concentration: 1.0
initial amount: NaN
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
type: Species
is: C04677
boundary condition: false
is: SBO:0000247
is: CHEBI:58475
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_587dd41a_fe07_4505_86a3_513911342a6e
is: SBO:0000252
has only substance units: false
name: CLYBL
initial concentration: NaN
boundary condition: true
type: Species
is: Q8N0X4
initial amount: NaN
is encoded by: hsa:171425
constant: false

metaR DGSNt
reactant: MODEL1310110027#
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110027#
fast: false
name: deoyguanosine transport via diffusion
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is: SBO:0000185

metaM xol7a r
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C03594
type: Species
initial concentration: 1.0
has only substance units: false
name: 20-hydroxycholesterol
is: CHEBI:1296
boundary condition: false
is: HMDB01496

metaM 44mzym r
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
is: HMDB01286
is: SBO:0000247
boundary condition: false
is: CHEBI:18364
name: 14-demethyllanosterol
constant: false
initial concentration: 1.0

metaM HC00460 c
type: Species
is: CHEBI:58044
name: 2,5-dihydroxybenzoate
initial concentration: 1.0
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_0f50058c_88b0_4f75_af91_7fbb1e54ec98
type: Species
name: EHHADH
has only substance units: false
constant: false
initial concentration: NaN
is: Q9NY65
is encoded by: hsa:1962
is: SBO:0000252
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_03f77036_505a_4eb5_afed_1ce689eafb86
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:23007
is: Q4KWH8
constant: false
has only substance units: false
name: PLCH1

metaR 7DHFtm
type: Reaction
reversible: false
is: SBO:0000185
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:unknown mechanism. IT
name: 7-glutamyl-DHF transport,m mitochondrial
is described by: ECO:0000000
reactant: MODEL1310110027#
fast: false
kinetic law: MODEL1310110027#

metaR r1599
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110027#

metaR r1443
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110027#
type: Reaction
fast: false
product: MODEL1310110027#
is: SBO:0000176
reactant: MODEL1310110027#
name: EC:1.3.3.6
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110027#_f51fde35_8daf_4b81_b51f_92463f3ce916
is: SBO:0000252
is: B4DNK4
name: PKM2
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:5315
boundary condition: true

metaM c4crn e
boundary condition: false
is: C02862
initial concentration: 1.0
notes: FORMULA: C11H21NO4 CHARGE: 0
has only substance units: false
type: Species
name: butyryl carnitine
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/213144
is: HMDB02013
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_21f2727a_9077_4b15_9fa1_7bc64bf9882f
is encoded by: hsa:4719
initial concentration: NaN
name: NDUFS1
has only substance units: false
is: P28331
type: Species
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN

metaR r0557
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:9620315 NOTES:
is described by: ECO:0000000
product: MODEL1310110027#
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
reversible: false
type: Reaction
name: Glutaryl-CoA:dihydrolipoamide S-succinyltransferase Lysine degradation EC:2.3.1.61
modifier: MODEL1310110027#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110027#_b97b6438_51dc_4b35_b0f9_f2478df203d2
initial amount: NaN
has part: Q9UHI5
constant: false
has only substance units: false
name: SLC7A8:SLC3A2
initial concentration: NaN
type: Species
is encoded by: hsa:23428
boundary condition: true
is: SBO:0000297

metaR r2310
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110027#
is: SBO:0000185
reversible: true
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110027#

metaR ALADGLYexR
fast: false
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110027#
is described by: ECO:0000304
reactant: MODEL1310110027#
name: D-alanine/glycine reversible exchange
is: SBO:0000185
modifier: MODEL1310110027#

metaM hdca e
notes: FORMULA: C16H31O2 CHARGE: -1
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: Hexadecanoate (n-C16:0)
is: HMDB00220
is: CHEBI:0
type: Species
is: C00249
initial amount: NaN
constant: false

metaR PEt
fast: false
product: MODEL1310110027#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110027#
type: Reaction
name: phosphatidylethanolamine transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:
reactant: MODEL1310110027#
reversible: true

metaR FAOXC102C81m
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)m
type: Reaction

metaM 2hb c
name: 2-Hydroxybutyrate
is: CHEBI:1148
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB00008
constant: false
type: Species
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
is: SBO:0000247
initial amount: NaN

metaR r0450
type: Reaction
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
is: SBO:0000176
reactant: MODEL1310110027#
modifier: MODEL1310110027#
fast: false
kinetic law: MODEL1310110027#
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
is described by: ECO:0000000
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/4.2.1.3
reversible: true

metaR ME1m
kinetic law: MODEL1310110027#
product: MODEL1310110027#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4200.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: NOTES:NCD
name: malic enzyme (NAD), mitochondrial
reactant: MODEL1310110027#
reversible: false
modifier: MODEL1310110027#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.38

metaR 4MOPt2im
reactant: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
kinetic law: MODEL1310110027#
is described by: ECO:0000000
name: 4-methyl-2-oxopentanoate mitochondrial transport via proton symport
fast: false
reversible: false
product: MODEL1310110027#
is: SBO:0000185

metaM cytd c
is: HMDB00089
constant: false
has only substance units: false
type: Species
is: C00475
initial amount: NaN
initial concentration: 1.0
name: Cytidine
is: CHEBI:17562
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_78049dc2_dac0_4edb_9350_e86a1d5fac1f
is: Q6AI14
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
name: SLC9A4
is encoded by: hsa:389015
is: SBO:0000252

metaM xtsn c
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:18107
is: SBO:0000247
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
type: Species
name: xanthosine
has only substance units: false
is: HMDB00299

metaR r1010
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
type: Reaction
reactant: MODEL1310110027#
name: Postulated transport reaction
kinetic law: MODEL1310110027#

metaR HMGCOAtx
fast: false
is: SBO:0000185
reactant: MODEL1310110027#
name: Hydroxymethylglutaryl-CoA reversible peroxisomal transport
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:diffusion NJ
kinetic law: MODEL1310110027#

metaR EX retn LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinoate exchange
type: Reaction

metaM clpndcoa c
initial concentration: 1.0
is: HMDB06267
is: C16166
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: clupanodonyl CoA
type: Species
boundary condition: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
is: http://identifiers.org/pubchem.compound/47205476
constant: false

metaM i c
has only substance units: false
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
type: Species
constant: false
is: HMDB12238
initial concentration: 1.0
initial amount: NaN
name: iodide
is: SBO:0000247
boundary condition: false
is: CHEBI:16382

metaM dump n
is: CHEBI:246422
is: HMDB01409
initial amount: NaN
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
is: SBO:0000247
constant: false
name: dUMP(2-)
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110027#_f05d0f0b_c4b6_4ea0_9a00_95dd2487d491
initial amount: NaN
boundary condition: true
is: Q9UHW9
initial concentration: NaN
is: SBO:0000252
constant: false
name: SLC12A6
has only substance units: false
is encoded by: hsa:9990
type: Species

metaR r0998
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110027#
product: MODEL1310110027#
reversible: true
name: Facilitated diffusion

metaR THRGLYexR
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110027#
reversible: true
product: MODEL1310110027#
reactant: MODEL1310110027#
name: L-threonine/glycine reversible exchange
type: Reaction
is: SBO:0000185
is described by: ECO:0000304
fast: false
modifier: MODEL1310110027#

metaM ksii core2 deg8 l
is: CHEBI:12936
is: HMDB00143
boundary condition: false
constant: false
name: keratan sulfate II (core 2-linked), degradation product 8
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C36H60N3O25X CHARGE: 0

metaM acald e
has only substance units: false
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
name: acetaldehyde
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:15343
type: Species
initial amount: NaN
is: HMDB00990

http://identifiers.org/biomodels.db/MODEL1310110027#_edbd8a86_3501_49e2_b53a_828d39020b56
is encoded by: hsa:10678
name: B3GNT2
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
has only substance units: false
boundary condition: true
is: Q9NY97
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_94aef394_5e7d_4157_9287_b10ba669c9c3
initial concentration: NaN
boundary condition: true
name: B4GALT2
initial amount: NaN
is encoded by: hsa:8704
type: Species
constant: false
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_fc723059_3c82_4ecd_b69f_7265a7d9e665
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
is: P34896
type: Species
boundary condition: true
is encoded by: hsa:6470
name: SHMT1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_1f876fdc_a1da_41ff_ac86_7b81ce06d2a2
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: UCP2
type: Species
is: P55851
boundary condition: true
is encoded by: hsa:7351
has only substance units: false

metaR DGNSKm
notes: GENE_ASSOCIATION: (1716.5) or (1716.1) or (1716.4) or (1716.2) or (1716.3) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 4 AUTHORS: PMID:12535661,PMID:8692979 NOTES:
product: MODEL1310110027#
type: Reaction
modifier: MODEL1310110027#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110027#
name: deoxyguanosine kinase
is version of: http://identifiers.org/ec-code/2.7.1.113
is described by: ECO:0000269
reactant: MODEL1310110027#
reversible: false

metaM zymst r
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
name: zymosterol
is: HMDB06271
is: CHEBI:18252

metaR SUBERCROT
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberyl carnitine
type: Reaction

metaR CHOLtn
is: SBO:0000185
kinetic law: MODEL1310110027#
name: Choline transport, nuclear through pores
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
reversible: true
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000000
fast: false
type: Reaction

metaR AHEXASEly
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110027#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
product: MODEL1310110027#
reversible: false
kinetic law: MODEL1310110027#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110027#_d3b66954_00d0_44bc_ab29_e928276d6185
initial concentration: NaN
has only substance units: false
name: CTPS2
is: SBO:0000252
is encoded by: hsa:56474
is: Q9NRF8
boundary condition: true
type: Species
initial amount: NaN
constant: false

metaM dopa e
is: SBO:0000247
has only substance units: false
is: CHEBI:59905
boundary condition: false
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
initial amount: NaN
is: HMDB00073
name: dopaminium(1+)
type: Species
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110027#_ec1d37fb_f4b9_40b2_930e_1231c707b58c
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
name: PPCDC
has only substance units: false
is: Q96CD2
initial concentration: NaN
is encoded by: hsa:60490

http://identifiers.org/biomodels.db/MODEL1310110027#_676c0c61_123f_48b7_b041_3e46f8196357
type: Species
is: SBO:0000252
name: PIK3R3
has only substance units: false
is: Q92569
is encoded by: hsa:8503
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false

metaR r2068
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110027#
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
is described by: ECO:0000000
product: MODEL1310110027#

metaR r0668
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
fast: false
product: MODEL1310110027#
reactant: MODEL1310110027#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.19
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
is described by: ECO:0000000

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

metaM ksi pre15 g
name: keratan sulfate I biosynthesis, precursor 15
type: Species
initial amount: NaN
is: C00130
is: SBO:0000247
notes: FORMULA: C149H240N10O119S4X CHARGE: -5
constant: false
initial concentration: 1.0
is: HMDB00175
boundary condition: false
has only substance units: false
is: CHEBI:58053

metaR r0999
kinetic law: MODEL1310110027#
is described by: ECO:0000000
reactant: MODEL1310110027#
name: Facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
product: MODEL1310110027#
reversible: true
is: SBO:0000185
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_e0eecff0_abac_49d7_bd9c_cba0143edfa5
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:10861
initial amount: NaN
constant: false
is: Q9H2B4
name: SLC26A1
has only substance units: false

metaM prpp e
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:58017
is: SBO:0000247
is: HMDB00280
boundary condition: false
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
has only substance units: false
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Species

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

metaM oagd3 hs c
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:17315
is: HMDB01514
is: SBO:0000247
is: C00329
constant: false
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
has only substance units: false
boundary condition: false
name: 9-O-Acetylated GD3

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

metaM hdca c
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
initial concentration: 1.0
type: Species
is: CHEBI:7896
has only substance units: false
boundary condition: false
name: palmitate
is: HMDB00220
constant: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_d629235d_14fe_4f89_9621_49a2d8fa1e63
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: ATP2B3
boundary condition: true
initial concentration: NaN
is encoded by: hsa:492
is: Q16720
constant: false
type: Species

metaR CYTK11n
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
type: Reaction
product: MODEL1310110027#
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,dGTP),nuclear
reversible: true
is described by: ECO:0000269
fast: false
reactant: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_8bb532ce_c2f7_4702_b10a_06f1a9cea78c
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
is: O15245
is encoded by: hsa:6580
constant: false
initial concentration: NaN
name: SLC22A1
initial amount: NaN

metaR RETI1
reactant: MODEL1310110027#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
fast: false
type: Reaction
product: MODEL1310110027#
is: SBO:0000176
kinetic law: MODEL1310110027#
name: retinol isomerase (11-cis)
is described by: ECO:0000000

metaM dd5ecoa m
is: http://identifiers.org/pubchem.compound/16019966
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
type: Species
name: 5-dodecenoylcoa
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false

metaR GLNTHRNaEx
type: Reaction
fast: false
name: L-threonine/L-glutamine Na-dependent exchange (Gln-L in)
modifier: MODEL1310110027#
is: SBO:0000185
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
product: MODEL1310110027#
is described by: ECO:0000269
reactant: MODEL1310110027#

metaR OAGD3tg
reversible: true
fast: false
product: MODEL1310110027#
reactant: MODEL1310110027#
name: oagd3 hs intracellular transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
kinetic law: MODEL1310110027#
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110027#_b0f000d7_7283_495d_ab00_33750e059290
name: HADH
is encoded by: hsa:3033
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is: Q16836

http://identifiers.org/biomodels.db/MODEL1310110027#_05664af1_4839_4e15_8768_77814bfa357b
type: Species
name: COASY
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
is: Q13057
initial amount: NaN
is encoded by: hsa:80347

metaR r2069
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
kinetic law: MODEL1310110027#
is described by: ECO:0000000
product: MODEL1310110027#
fast: false
is: SBO:0000185
reactant: MODEL1310110027#
type: Reaction

metaM ala D e
is: SBO:0000247
is: CHEBI:15570
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
is: HMDB01310
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
name: D-alanine
has only substance units: false

metaM gthrd e
has only substance units: false
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: CHEBI:57925
initial amount: NaN
type: Species
name: glutathionate(1-)
is: SBO:0000247
initial concentration: 1.0
is: HMDB00125
constant: false
boundary condition: false

metaM lnlncg r
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:32391
has only substance units: false
is: HMDB03073
constant: false
type: Species
boundary condition: false
initial amount: NaN
name: gamma-linolenate

metaR RETI2
fast: false
name: retinol isomerase (9-cis)
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reversible: true
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
product: MODEL1310110027#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_ab0852b6_51f6_41d1_a5c9_90d048d44e1e
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: P55084
has only substance units: false
type: Species
constant: false
name: HADHB
is encoded by: hsa:3032
boundary condition: true

metaM acald c
name: acetaldehyde
is: HMDB00990
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15343
type: Species
constant: false
initial amount: NaN
has only substance units: false

metaM clpn hs c
boundary condition: false
name: clpn_hs[c]
notes: FORMULA: CHARGE: 0
initial concentration: 1.0
is: CHEBI:15589
is: SBO:0000247
is: HMDB00156
has only substance units: false
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_e87dcd38_53c7_454e_a485_28be8ef98270
is encoded by: hsa:AV717590
is: SBO:0000252
constant: false
name: _AV717590_1_m
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_12bb7d3c_1ee9_44f3_ab61_88111d3d09ba
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:3948
is: SBO:0000252
initial amount: NaN
constant: false
name: LDHC
initial concentration: NaN

metaM leuktrB4 e
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01085
is: SBO:0000247
is: CHEBI:57461
name: leukotriene B4(1-)
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_35fec4e4_1e95_493f_a5a4_705541bcc763
constant: false
type: Species
is encoded by: hsa:10991
initial amount: NaN
boundary condition: true
is: Q99624
name: SLC38A3
initial concentration: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_16515c31_9f0a_4b54_90e8_0302de5b730c
constant: false
is encoded by: hsa:BC005314
name: _BC005314_1_x
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_e6af7311_2633_4201_aff9_c6867d11980c
has only substance units: false
is encoded by: hsa:3421
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
name: IDH3A:IDH3B:IDH3G
has part: P51553
is encoded by: hsa:3420
has part: O43837
is: SBO:0000297
type: Species

metaR r0139
reversible: true
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is version of: http://identifiers.org/ec-code/2.3.2.2
fast: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110027#
reactant: MODEL1310110027#
product: MODEL1310110027#
kinetic law: MODEL1310110027#

metaR SERtN1
fast: false
product: MODEL1310110027#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
type: Reaction
modifier: MODEL1310110027#
is described by: ECO:0000269
name: Serine transport (Na, H coupled)
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#

metaR r1447
is described by: ECO:0000000
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
is: SBO:0000176
reactant: MODEL1310110027#
fast: false
name: EC:1.3.3.6
kinetic law: MODEL1310110027#
product: MODEL1310110027#

metaM i e
constant: false
is: HMDB12238
has only substance units: false
type: Species
initial concentration: 1.0
name: iodide
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
is: CHEBI:16382

metaR FAOXC163C164Gm
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)gm
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_e9cbdba2_804b_4507_8453_52aad2f27965
boundary condition: true
is encoded by: hsa:3948
constant: false
is: SBO:0000252
name: LDHC
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is: P07864

metaR r0666
reversible: true
is version of: http://identifiers.org/ec-code/1.2.4.2
is described by: ECO:0000000
name: 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) Purine metabolism EC:6.3.3.1
product: MODEL1310110027#
type: Reaction
fast: false
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Purine synthesis EC Number: 6.3.3.1 Confidence Level: 0 AUTHORS: PMID:4084560 NOTES:

metaR S6T13g
is described by: ECO:0000000
reactant: MODEL1310110027#
product: MODEL1310110027#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (4166.1) or (10164.1) or (23563.2) or (23563.1) or (9435.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
fast: false
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110027#

metaM udp c
is: HMDB00295
type: Species
is: SBO:0000247
constant: false
is: CHEBI:58223
is: C00015
boundary condition: false
initial amount: NaN
name: UDP
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110027#_517b1205_f6cd_4048_bc9f_87b95f254a43
initial concentration: NaN
is: Q969I6
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:55089
boundary condition: true
constant: false
name: SLC38A4

metaR RETI3
reversible: true
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 4 AUTHORS: PMID:11606944 NOTES:IT
fast: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
name: retinol isomerase (13-cis)

metaM HC01401 x
is: CHEBI:27668
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: (S)-3-Hydroxydodecanoyl-CoA
type: Species
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
boundary condition: false
constant: false
has only substance units: false

metaM man l
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
initial amount: NaN
boundary condition: false
constant: false
name: D-mannose
is: SBO:0000247
has only substance units: false
is: CHEBI:16024
is: HMDB00169
type: Species

metaM HC02175 e
name: caprate
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:27689

metaR TREHe
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
is: SBO:0000176
is described by: ECO:0000269
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.28
type: Reaction
product: MODEL1310110027#
modifier: MODEL1310110027#
name: alpha,alpha-trehalase
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR

metaM dopa c
boundary condition: false
is: CHEBI:59905
is: SBO:0000247
name: dopaminium(1+)
is: HMDB00073
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758

metaR RE2799C
type: Reaction
reversible: true
name: RE2799
kinetic law: MODEL1310110027#
is: SBO:0000176
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110027#

metaM prpp c
is: C00119
is: CHEBI:58017
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
initial concentration: 1.0
initial amount: NaN
is: HMDB00280
type: Species
name: 5-Phospho-alpha-D-ribose 1-diphosphate
boundary condition: false

metaM lnlccrn c
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
name: Linoleyl carnitine
initial amount: NaN
constant: false
is: HMDB06469

http://identifiers.org/biomodels.db/MODEL1310110027#_5d161978_2ba6_4469_93d3_d5c6069f1f9e
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:AA081045
has only substance units: false
initial amount: NaN
name: _AA081045_1_c
initial concentration: NaN
boundary condition: true

metaR OAGD3te
is: SBO:0000185
reactant: MODEL1310110027#
product: MODEL1310110027#
reversible: true
type: Reaction
name: oagd3 hs transport
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ

http://identifiers.org/biomodels.db/MODEL1310110027#_9437772b_d200_4141_abef_2a6a99d36656
is: Q9UBX3
boundary condition: true
is encoded by: hsa:1468
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
name: SLC25A10

metaM prostgd2 e
type: Species
is: HMDB01403
initial amount: NaN
is: SBO:0000247
is: CHEBI:57406
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: prostaglandin D2(1-)
constant: false

metaM cys L c
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
is: SBO:0000247
name: L-cysteine
constant: false
is: HMDB00574
boundary condition: false
initial concentration: 1.0
is: CHEBI:17561

metaM xoltri27 r
initial amount: NaN
is: CHEBI:18431
is: SBO:0000247
is: HMDB06281
name: 7alpha,26-dihydroxycholesterol
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h15,17-18,20-25,28-30H,5-14,16H2,1-4H3/t17?,18-,20+,21-,22+,23+,24-,25+,26+,27-/m1/s1
type: Species
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110027#_4a7f779a_5a12_49bd_acab_926ed1a4f69d
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
name: INPP1
constant: false
is encoded by: hsa:3628
is: SBO:0000252
has only substance units: false
is: P49441

http://identifiers.org/biomodels.db/MODEL1310110027#_2028a39a_60f4_4767_b218_7d3c089bb62b
has only substance units: false
type: Species
is: Q6NVC0
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: SLC25A5
is encoded by: hsa:292
constant: false
boundary condition: true

metaM C05965 e
has only substance units: false
type: Species
is: CHEBI:57444
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
constant: false
name: 12(S)-HPETE(1-)
initial amount: NaN
initial concentration: 1.0
is: HMDB04243
is: SBO:0000247
boundary condition: false

metaM rbt e
has only substance units: false
constant: false
type: Species
is: CHEBI:15963
is: HMDB00508
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
is: SBO:0000247
initial amount: NaN
name: D-ribitol
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110027#_76a177c8_3610_48ee_ad8d_8f26bffd20ff
name: _H77542_1_r
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:H77542
type: Species
has only substance units: false
boundary condition: true
constant: false

metaM fum m
has only substance units: false
type: Species
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
is: C00122
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:29806
name: Fumarate
initial amount: NaN
is: HMDB00134
constant: false

metaM gthrd c
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:57925
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: HMDB00125
name: Reduced glutathione
is: C00051

metaR NADPHtru
is described by: ECO:0000000
name: NADPH transporter, endoplasmic reticulum
kinetic law: MODEL1310110027#
product: MODEL1310110027#
fast: false
is: SBO:0000185
reversible: false
reactant: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ

metaM ala D c
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
is: SBO:0000247
is: CHEBI:15570
boundary condition: false
initial concentration: 1.0
is: HMDB01310
name: D-alanine
has only substance units: false
initial amount: NaN
type: Species
constant: false

metaR OAADC
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: oxaloacetate decarboxylase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_80a618d8_abcf_4a7b_8f1d_83b925ef20b1
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5831
type: Species
name: PYCR1
constant: false
is: A6NFM2
initial amount: NaN

metaR DM 4abut LPAREN n RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: PMID: 16643338 NOTES:GABA in the intestine may aid in differentiation and proliferation of epithelial cells. GABA intake by oral administration has been shown to alleviate stress, worry and anxiety and additionally it can also improve human immunity (PMID: 16971751). However the PAT1 transporter located at the apical side of enterocytes have very low affinity for GABA. I have presumed that this oral GABA is used within intestine (unless administered at high very high pharmacological doses, GABA exit from the enterocytes may be mediated by other specifc transporters).
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for 4-Aminobutanoate(n)
type: Reaction

metaR SGPL12r
is version of: http://identifiers.org/ec-code/4.1.2.27
fast: false
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ
is described by: ECO:0000304
type: Reaction
reactant: MODEL1310110027#
name: Sphingosine-1-phosphate lyase
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110027#_57696fa5_f70b_42ff_a695_163f683a00d6
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
is: Q8NFL0
name: B3GNT7
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:93010

metaR RE1525M
product: MODEL1310110027#
name: RE1525
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
is described by: ECO:0000000
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
reversible: true
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
modifier: MODEL1310110027#

metaM prgstrn e
initial amount: NaN
constant: false
notes: FORMULA: C21H30O2 CHARGE: 0 INCHI: InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C00410
type: Species
is: HMDB01830
boundary condition: false
is: CHEBI:17026
is: SBO:0000247
name: progesterone
has only substance units: false
initial concentration: 1.0

metaR PEAMNO
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.4.3.21
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.22
modifier: MODEL1310110027#
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.4.3.4
is: SBO:0000176
name: Phenethylamine oxidase
notes: GENE_ASSOCIATION: (314.1) or (4128.1) or (26.1) or (4129.1) or (314.2) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:10389141,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:JLR- Kegg reaction R02613
is described by: ECO:0000304
reactant: MODEL1310110027#
fast: false

metaM retinal r
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:15035
name: retinal
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
is: HMDB01358

metaM leuktrB4 c
is: CHEBI:57461
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
constant: false
initial amount: NaN
is: HMDB01085
is: SBO:0000247
boundary condition: false
name: leukotriene B4(1-)

metaR D LACt2
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
is described by: ECO:0000269
fast: false
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
name: D-lactate transport via proton symport
reversible: true
type: Reaction
reactant: MODEL1310110027#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110027#_c7a7a8aa_b195_4db6_a2c6_821b3c74df15
has only substance units: false
is encoded by: hsa:6392
type: Species
initial amount: NaN
is: SBO:0000297
constant: false
is encoded by: hsa:6389
has part: P31040
is encoded by: hsa:6390
has part: O14521
is encoded by: hsa:6391
boundary condition: true
has part: P21912
initial concentration: NaN
name: SDHA:SDHB:SDHC:SDHD
has part: Q99643

metaM udp e
is: CHEBI:58223
name: UDP(3-)
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
is: HMDB00295
is: SBO:0000247
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015

http://identifiers.org/biomodels.db/MODEL1310110027#_b16df90b_da27_4a21_949d_e6603d7f7b31
boundary condition: true
has only substance units: false
is encoded by: hsa:8897
is: SBO:0000252
name: MTMR3
type: Species
initial amount: NaN
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_94a554c9_42e1_4ad2_965b_874603ca37a4
constant: false
is: SBO:0000252
initial concentration: NaN
is: P28332
initial amount: NaN
type: Species
name: ADH6
has only substance units: false
boundary condition: true
is encoded by: hsa:130

metaM oagd3 hs g
type: Species
is: C00329
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: 9-O-Acetylated GD3
is: HMDB01514
boundary condition: false
is: CHEBI:17315
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
is: SBO:0000247
constant: false

metaR NAGLCAly
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 1 AUTHORS: NOTES:EC 3.2.1.- This reaction is my best guess at how the GlcNAc-beta-1,6-GalNAc linkage is cleaved. NCD
product: MODEL1310110027#
kinetic law: MODEL1310110027#
is: SBO:0000176
name: N-acetylglucosaminidase, lysosomal
reversible: false
type: Reaction
reactant: MODEL1310110027#
fast: false
is described by: ECO:0000000

metaM CE2434 m
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
is: SBO:0000247
has only substance units: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
is: CHEBI:57795
type: Species
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110027#_e5a5154b_3b0e_4b73_9295_55c3ac7ace57
name: LDHC
constant: false
is: P07864
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:3948
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_8318e6b6_da39_41b4_9f66_b9f8a2d3f996
constant: false
name: PAPSS2
boundary condition: true
is encoded by: hsa:9060
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
is: O95340

metaM g3p c
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB01112
is: CHEBI:58027
name: Glyceraldehyde 3-phosphate
type: Species
is: http://identifiers.org/pubchem.compound/3930
initial concentration: 1.0
is: C00661
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_3f2eb63f_43dd_4af5_88fc_f47d995e004b
name: QDPR
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
is: P09417
type: Species
is encoded by: hsa:5860
initial amount: NaN

metaR r0661
is described by: ECO:0000000
kinetic law: MODEL1310110027#
reversible: false
product: MODEL1310110027#
type: Reaction
fast: false
reactant: MODEL1310110027#
is: SBO:0000176
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:

metaM acgam1p c
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
is: HMDB01367
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01256 EHMN_ABBREVIATION: C04256
initial amount: NaN
is: CHEBI:7125
name: N-Acetyl-D-glucosamine 1-phosphate
boundary condition: false

metaR G12MT1 L
kinetic law: MODEL1310110027#
name: Glycolipid 1,2-alpha-D-mannosyltransferase (liver)
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reversible: false
product: MODEL1310110027#
reactant: MODEL1310110027#
fast: false

metaM prostgd2 c
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
constant: false
type: Species
has only substance units: false
is: HMDB01403
is: CHEBI:57406
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: prostaglandin D2(1-)

metaM 2hb e
name: 2-Hydroxybutyrate
is: CHEBI:1148
type: Species
constant: false
has only substance units: false
boundary condition: false
is: HMDB00008
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
is: SBO:0000247

metaM leu L m
type: Species
is: SBO:0000247
constant: false
name: L-leucine
is: HMDB00687
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
boundary condition: false
initial amount: NaN
is: CHEBI:15603

metaR r2319
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110027#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaM chito2pdol L c
type: Species
is: HMDB01196
name: N,N'-Diacetylchitobiosyldiphosphodolichol, human liver homolog
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C1240H2028N20O170P20 CHARGE: -20 INCHI: InChI=1S/C41H72N2O17P2/c1-25(2)13-9-14-26(3)15-10-16-27(4)17-11-18-28(5)19-12-20-29(6)21-22-55-61(51,52)60-62(53,54)59-41-35(43-31(8)47)38(50)39(33(24-45)57-41)58-40-34(42-30(7)46)37(49)36(48)32(23-44)56-40/h13,15,17,19,29,32-41,44-45,48-50H,9-12,14,16,18,20-24H2,1-8H3,(H,42,46)(H,43,47)(H,51,52)(H,53,54)/b26-15+,27-17+,28-19-/t29?,32-,33-,34-,35-,36-,37-,38-,39-,40+,41-/m1/s1
constant: false
initial amount: NaN
is: CHEBI:12427
boundary condition: false

metaM tcynt m
name: thiocyanate
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:18022
is: HMDB01453
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755

http://identifiers.org/biomodels.db/MODEL1310110027#_9002081d_5b39_454a_9b1d_f688e629030d
initial concentration: NaN
name: HSD3B1
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
is: P14060
is encoded by: hsa:3283
type: Species

metaM ser L m
has only substance units: false
name: L-serine
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:17115
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: HMDB00187
constant: false

metaM hdd2coa x
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h16-17,24-26,30-32,36,47-48H,4-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b17-16+/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
initial concentration: 1.0
has only substance units: false
constant: false
name: (E)-hexadec-2-enoyl-CoA(4-)
boundary condition: false
is: SBO:0000247
is: CHEBI:61526
type: Species
is: HMDB03945
initial amount: NaN

metaR SUBERCACT
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberyl carnitine into cytosol
type: Reaction

metaM 10fthf6glu e
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1
is: SBO:0000247
initial concentration: 1.0
is: HMDB00108
name: 10-formyltetrahydrofolate-[Glu](6)
type: Species
is: CHEBI:16236

metaR DHCR242r
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.3.1.72
kinetic law: MODEL1310110027#
fast: false
is: SBO:0000176
is described by: ECO:0000134
name: 24-dehydrocholesterol reductase [Precursor]
type: Reaction
reactant: MODEL1310110027#
product: MODEL1310110027#
reversible: false

metaR RE3003M
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
kinetic law: MODEL1310110027#
name: RE3003
type: Reaction
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/5.3.3.8

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_b9a3d140_8a1d_4cb6_9b1a_ce5841dd18f0
is encoded by: hsa:2629
initial concentration: NaN
is: SBO:0000252
type: Species
is: P04062
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
name: GBA

http://identifiers.org/biomodels.db/MODEL1310110027#_a6e24c43_a2a2_4e47_a8bc_ef8543a64add
is: Q9HC58
name: SLC24A3
is encoded by: hsa:57419
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false

metaR r0451
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) Lysine degradation EC:1.2.4.2
type: Reaction
is: SBO:0000176
reactant: MODEL1310110027#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
fast: false
product: MODEL1310110027#
kinetic law: MODEL1310110027#
is described by: ECO:0000000

metaM HC01603 c
is: C00234
is: CHEBI:57454
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
boundary condition: false
name: 10-Formyltetrahydrofolate
initial concentration: 1.0
constant: false
is: SBO:0000247

metaR CMPACNAtn
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
reversible: false
fast: false
kinetic law: MODEL1310110027#
is described by: ECO:0000000
product: MODEL1310110027#
reactant: MODEL1310110027#
name: CMP-Sia nuclear export

http://identifiers.org/biomodels.db/MODEL1310110027#_1044a273_ffc8_4f55_b0c0_aff2b354a47d
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:1581
boundary condition: true
is: P22680
constant: false
name: CYP7A1
initial amount: NaN

metaM dhbpt c
has only substance units: false
boundary condition: false
is: HMDB00038
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
is: CHEBI:20680
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
name: 6,7-dihydrobiopterin

metaM HC01231 c
type: Species
initial concentration: 1.0
is: CHEBI:58480
boundary condition: false
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
constant: false
has only substance units: false
is: SBO:0000247
name: N-[(R)-pantothenoyl]-L-cysteinate
initial amount: NaN

metaR Q10H2e
name: transport of ubiquinol into lymph
reversible: true
type: Reaction
product: MODEL1310110027#
fast: false
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
is: SBO:0000185
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.

metaR r2318
product: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
is described by: ECO:0000000

metaM cys L e
type: Species
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:17561
boundary condition: false
name: L-cysteine
is: HMDB00574

metaM udp g
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
initial amount: NaN
type: Species
initial concentration: 1.0
name: UDP(3-)
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB00295
is: CHEBI:58223

http://identifiers.org/biomodels.db/MODEL1310110027#_2f0b34ea_5516_4ada_b16c_7cd36c406ca3
name: PDE7A
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:5150
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252

metaM glyc m
name: Glycerol
is: CHEBI:17754
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
type: Species
initial concentration: 1.0
is: HMDB00131
initial amount: NaN
is: C00116
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_688a62e6_2bf5_4c63_b237_81709eb79402
has only substance units: false
is encoded by: hsa:3156
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: P04035
constant: false
name: HMGCR
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_27ec4f52_5634_4d59_add8_ae3e1e950a08
name: MAN2A2
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4122
is: Q9P1E4

metaM oagd3 hs e
is: SBO:0000247
constant: false
is: CHEBI:18421
type: Species
is: HMDB02168
has only substance units: false
initial concentration: 1.0
name: 9-O-Acetylated GD3
boundary condition: false
initial amount: NaN
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2

metaR MM5ag
reversible: false
reactant: MODEL1310110027#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.113
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
product: MODEL1310110027#
is: SBO:0000176
fast: false

metaM HC00342 m
boundary condition: false
has only substance units: false
initial amount: NaN
name: cis-aconitate(3-)
is: CHEBI:16383
is: SBO:0000247
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
initial concentration: 1.0
type: Species
constant: false

metaM gly c
is: C00037
initial concentration: 1.0
has only substance units: false
is: HMDB00123
is: CHEBI:3339
is: SBO:0000247
boundary condition: false
type: Species
name: Glycine
initial amount: NaN
constant: false
notes: FORMULA: C2H5NO2 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110027#_5fff07f8_7f84_49ee_a0c9_070680892313
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
is: H0YMZ7
is encoded by: hsa:5151
initial amount: NaN
constant: false
name: PDE8A

metaR SADT
is: SBO:0000176
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.1.25
kinetic law: MODEL1310110027#
fast: false
name: sulfate adenylyltransferase
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
type: Reaction
reactant: MODEL1310110027#
reversible: false
product: MODEL1310110027#
is described by: ECO:0000269

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_ac42ce9e_1929_47cb_a5ae_8f1b66a240fc
is encoded by: hsa:55577
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
type: Species
name: NAGK
initial amount: NaN
initial concentration: NaN
is: Q9UJ70

http://identifiers.org/biomodels.db/MODEL1310110027#_773b8601_3565_4d99_8df5_572a98f6e7f0
constant: false
type: Species
is: SBO:0000252
is: P36969
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2879
boundary condition: true
has only substance units: false
name: GPX4

http://identifiers.org/biomodels.db/MODEL1310110027#_96716e20_2451_4abf_8536_a8314f9e7b4d
is: B7Z6M3
has only substance units: false
initial amount: NaN
name: DGKZ
initial concentration: NaN
is encoded by: hsa:8525
type: Species
constant: false
boundary condition: true
is: SBO:0000252

metaR r1657
kinetic law: MODEL1310110027#
is: SBO:0000185
fast: false
reactant: MODEL1310110027#
reversible: true
type: Reaction
modifier: MODEL1310110027#
product: MODEL1310110027#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR CYTK1n
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
reversible: true
is described by: ECO:0000269
name: cytidylate kinase (CMP),nuclear
product: MODEL1310110027#
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM succoa x
has only substance units: false
boundary condition: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
initial amount: NaN
initial concentration: 1.0
name: Succinyl-CoA
is: HMDB01022
is: SBO:0000247
type: Species
constant: false

metaR SERDGLNexR
fast: false
is described by: ECO:0000304
kinetic law: MODEL1310110027#
reversible: true
is: SBO:0000185
name: D-Serine/Glutamine reversible exchange
modifier: MODEL1310110027#
product: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110027#

metaR RE0830C
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
name: RE0830
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
is: SBO:0000176
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
product: MODEL1310110027#

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_24a52993_3d23_4f1b_b4e2_8c61e5cc7aa0
is: O43678
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:4695
initial amount: NaN
name: NDUFA2

metaR DGCHOLte
product: MODEL1310110027#
reversible: true
name: bile acid intracellular transport
fast: false
reactant: MODEL1310110027#
is described by: ECO:0000000
kinetic law: MODEL1310110027#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_469fe576_08de_4a84_a3d3_299641432727
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:115286
constant: false
name: SLC25A26
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: F8WAB8

http://identifiers.org/biomodels.db/MODEL1310110027#_600db418_c5b2_4a24_b31b_a95fc4a74b65
boundary condition: true
is: B3KT70
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: HKDC1
constant: false
type: Species
is encoded by: hsa:80201

metaM dcsptn1coa x
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
constant: false
is: C16173
is: HMDB06513
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205483
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A

metaR r0812
fast: false
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.3.1.41
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110027#
reversible: true
reactant: MODEL1310110027#

metaM core3 g
is: SBO:0000247
has only substance units: false
notes: FORMULA: C16H27N2O10X CHARGE: 0
name: Core 3
is: CHEBI:16250
initial amount: NaN
type: Species
constant: false
boundary condition: false
initial concentration: 1.0

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

metaM dolglcp L c
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:15812
boundary condition: false
initial amount: NaN

metaM crn r
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial concentration: 1.0
type: Species
name: (R)-carnitine
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:16347
is: SBO:0000247
is: HMDB00062

http://identifiers.org/biomodels.db/MODEL1310110027#_176c8508_2113_4532_a159_5a2342a73db2
is encoded by: hsa:211
constant: false
type: Species
initial concentration: NaN
name: ALAS1
is: Q5JAM2
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaR UGALNACtg
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110027#
reversible: true
reactant: MODEL1310110027#
is: SBO:0000185
modifier: MODEL1310110027#
name: UDP-GalNAc Golgi transport via CMP antiport
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
fast: false

metaR CDIPTr
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
reversible: true
product: MODEL1310110027#
name: phosphatidylinositol synthase (Homo sapiens)
is: SBO:0000176
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD
is version of: http://identifiers.org/ec-code/2.7.8.11
type: Reaction
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110027#_af720c8e_8436_4f60_b862_e6bbebf7e602
initial concentration: NaN
boundary condition: true
is encoded by: hsa:8560
name: DEGS1
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: O15121
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_3571908a_dc64_4ebb_81fc_283689207409
has only substance units: false
name: AK2
boundary condition: true
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:204

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_1dae081b_c6e8_44ae_b5bd_6788a6c4bab4
type: Species
name: AK4
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:205
initial concentration: NaN
constant: false
is: SBO:0000252

metaM ksii core2 e
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: keratan sulfate II (core 2-linked)
type: Species
constant: false
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
is: HMDB00211
is: CHEBI:17268
has only substance units: false
boundary condition: false

metaR r1658
is described by: ECO:0000000
reactant: MODEL1310110027#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110027#
reversible: true
modifier: MODEL1310110027#

metaM 5adtststerones e
initial amount: NaN
name: 5alpha-Dihydrotestosterone sulfate
initial concentration: 1.0
constant: false
type: Species
is: HMDB06278
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032

http://identifiers.org/biomodels.db/MODEL1310110027#_0b08a7e7_b886_4f14_bdb9_fc60bbc144eb
type: Species
initial amount: NaN
initial concentration: NaN
name: GGH
is encoded by: hsa:8836
is: SBO:0000252
constant: false
boundary condition: true
is: Q92820
has only substance units: false

metaR FAOXC184m
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization of (C18:4)m
type: Reaction

metaR G14T6g
product: MODEL1310110027#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is described by: ECO:0000000
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.4.1.90
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110027#

metaM 6htststerone e
initial amount: NaN
notes: FORMULA: C19H28O3 CHARGE: 0 INCHI: InChI=1/C19H28O3/c1-18-7-5-11(20)9-15(18)16(21)10-12-13-3-4-17(22)19(13,2)8-6-14(12)18/h9,12-14,16-17,21-22H,3-8,10H2,1-2H3/t12-,13-,14-,16+,17-,18+,19-/m0/s1 EHMN_ABBREVIATION: C14497
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/17395497
has only substance units: false
is: C14497
name: 6 beta hydroxy testosterone
is: HMDB06259
type: Species
constant: false
is: SBO:0000247

metaR EX prostgi2 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin I2(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_60297867_bb5b_4ae8_9143_69ddabe4339b
has only substance units: false
name: SUCLG2
is: Q96I99
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:8801

metaM gpail hs c
has only substance units: false
boundary condition: false
is: CHEBI:17049
type: Species
notes: FORMULA: C15H28NO13PFULLRCO2FULLR2CO2 CHARGE: 0 EHMN_ABBREVIATION: C04248
name: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false

metaR NTD2e
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.1.3.5
is described by: ECO:0000134
modifier: MODEL1310110027#
product: MODEL1310110027#
kinetic law: MODEL1310110027#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (4907.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:2840110 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
name: 5'-nucleotidase (UMP), extracellular
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110027#_9ff41eb1_58ba_4673_a271_1b32c8dd1454
name: B4GALT5
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
is: O43286
initial amount: NaN
is encoded by: hsa:9334
has only substance units: false

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_89fae45f_422d_48b4_a6cc_1ce126cc9b65
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:11343
initial concentration: NaN
name: MGLL
type: Species
boundary condition: true
is: Q99685

metaR DCSPTN1CPT1
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110027#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
name: carnitine O-palmitoyltransferase
fast: false
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
product: MODEL1310110027#

metaR NAHCO3 HCLt
is: SBO:0000185
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
product: MODEL1310110027#
fast: false
type: Reaction
reactant: MODEL1310110027#
name: bicarbonate transport (HCl/NaHCO3 exchange)
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM

metaM h n
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: CHEBI:24636
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
name: proton
type: Species

metaR SRTNt6 2 r
is: SBO:0000185
reversible: true
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (6532.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
product: MODEL1310110027#
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
modifier: MODEL1310110027#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110027#_82192a76_3894_4d2f_828c_d0a3dd1bcd97
is encoded by: hsa:771
name: CA12
initial amount: NaN
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: O43570
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110027#_55b4ec1a_7104_441a_91db_35efacfc89f8
initial concentration: NaN
boundary condition: true
is encoded by: hsa:7296
type: Species
constant: false
initial amount: NaN
name: TXNRD1
has only substance units: false
is: SBO:0000252
is: Q16881

http://identifiers.org/biomodels.db/MODEL1310110027#_a6ec46e0_90c4_406e_b405_9d953af6a82a
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
is: Q9NVS9
name: PNPO
type: Species
is encoded by: hsa:55163

metaR r0399
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.4.2
product: MODEL1310110027#
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:
fast: false
kinetic law: MODEL1310110027#
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110027#

metaM CE0849 m
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
name: cis,cis-palmito-7,10-dienoyl-CoA
initial concentration: 1.0
type: Species
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849
constant: false
is: CHEBI:57795

http://identifiers.org/biomodels.db/MODEL1310110027#_60c70dce_8dad_4b9a_b86a_8accd1507411
boundary condition: true
initial concentration: NaN
is encoded by: hsa:55350
initial amount: NaN
type: Species
constant: false
name: VNN3
is: SBO:0000252
has only substance units: false

metaR SERGLNexR
fast: false
reversible: true
kinetic law: MODEL1310110027#
name: L-Serine/Glutamine reversible exchange
type: Reaction
modifier: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110027#_f4743097_d83f_40f3_a493_afe1065d6be5
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: SLC12A5
initial concentration: NaN
has only substance units: false
type: Species
constant: false
is encoded by: hsa:57468
is: Q9H2X9

http://identifiers.org/biomodels.db/MODEL1310110027#_91cafce8_c4d4_4c89_8fcd_918e69a236b0
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:5092
constant: false
name: PCBD1
is: P61457

metaR r1659
type: Reaction
modifier: MODEL1310110027#
product: MODEL1310110027#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110027#
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110027#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_29217cf7_ca66_4fc7_a5d1_a20a31c52211
initial amount: NaN
constant: false
name: SUCLG1:SUCLA2
has part: E5KS60
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:8803
initial concentration: NaN
is: SBO:0000297

metaR EX 3aib D LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-3-Amino-isobutanoate exchange
type: Reaction

metaR r0160
reversible: false
is version of: http://identifiers.org/ec-code/2.1.3.2
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.51 Confidence Level: 0 AUTHORS: PMID:10347152,PMID:6469715 NOTES:
name: L-Serine:pyruvate aminotransferase Glycine, serine and threonine metabolism EC:2.6.1.51
product: MODEL1310110027#
kinetic law: MODEL1310110027#
fast: false
is: SBO:0000176
modifier: MODEL1310110027#
reactant: MODEL1310110027#
type: Reaction
is described by: ECO:0000000

metaR ITCOAL1m
modifier: MODEL1310110027#
fast: false
is: SBO:0000176
reversible: true
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
is version of: http://identifiers.org/ec-code/6.2.1.4
reactant: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
is described by: ECO:0000304
kinetic law: MODEL1310110027#
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_53df2628_7de0_4a43_9a50_ec8e9983594f
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is: P04179
is: SBO:0000252
name: SOD2
boundary condition: true
is encoded by: hsa:6648
type: Species

metaR GLYCt
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110027#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110027#
name: glycerol transport via channel
reactant: MODEL1310110027#

metaR CYSSNAT5tc
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR SUCCt2m
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is: SBO:0000185
reactant: MODEL1310110027#
reversible: true
product: MODEL1310110027#
type: Reaction
name: succinate transport, mitochondrial
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_e6543bdb_3c6b_4c34_b401_844f90bdbbce
boundary condition: true
name: SLC4A2
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
is: F8W682
has only substance units: false
is encoded by: hsa:6522

metaR CYTK9n
reactant: MODEL1310110027#
reversible: true
product: MODEL1310110027#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
name: cytidylate kinase (CMP,dCTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
is described by: ECO:0000269

metaM ksii core2 g
initial amount: NaN
is: CHEBI:57255
name: keratan sulfate II (core 2-linked)
boundary condition: false
is: SBO:0000247
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
has only substance units: false
initial concentration: 1.0
is: HMDB01014
constant: false
type: Species

metaM ksi pre35 g
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
name: keratan sulfate I biosynthesis, precursor 35
notes: FORMULA: C241H384N17O205S11X CHARGE: -12
is: CHEBI:28067
boundary condition: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_9a501144_626a_4e8b_b986_d2da36aa82f8
is encoded by: hsa:6510
is: SBO:0000252
name: SLC1A5
is: Q15758
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false

metaR PRFGS
product: MODEL1310110027#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (5198.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/6.3.5.3
type: Reaction
reversible: false
is: SBO:0000176
name: phosphoribosylformylglycinamidine synthase
reactant: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_c05185c9_b774_4399_9ac5_b78c3dc229bd
type: Species
is encoded by: hsa:257068
initial amount: NaN
is: Q0VAA5
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
name: PLCXD2

http://identifiers.org/biomodels.db/MODEL1310110027#_d52e4984_3169_4d14_ad74_4abd47b7999e
is encoded by: hsa:1339
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
is: Q02221
has only substance units: false
name: COX6A2
constant: false
initial amount: NaN

metaR r1540
type: Reaction
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
modifier: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.17.4.1
reversible: false
kinetic law: MODEL1310110027#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:

metaR r1653
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110027#
reactant: MODEL1310110027#
is: SBO:0000185
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110027#
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_3b36244c_e03d_473f_81b7_4a815fe1809f
name: DTYMK
is: P23919
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1841
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_a5c3dd09_5f00_4073_93f1_ab3d38a7f940
is: SBO:0000252
type: Species
is encoded by: hsa:5959
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
is: Q92781
name: RDH5
constant: false

metaM ksii core2 pre5 g
type: Species
is: CHEBI:58053
boundary condition: false
is: HMDB00175
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 5
notes: FORMULA: C61H99N5O43X CHARGE: -1
constant: false
initial amount: NaN
is: C00130
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110027#_e2e52f09_1774_4da3_97cd_5d806029288b
constant: false
type: Species
name: CHST6
boundary condition: true
initial concentration: NaN
is: Q9GZX3
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4166
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_8c3b759e_1da7_411c_a199_42fc2e9958b7
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
name: B3GNT8
is: Q7Z7M8
constant: false
is encoded by: hsa:374907
has only substance units: false

metaR FAOXC101C102m
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)m
type: Reaction

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

metaM dhap e
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
is: HMDB01473
constant: false
boundary condition: false
name: glycerone phosphate(2-)
is: CHEBI:57642
is: SBO:0000247

metaM HC02204 e
type: Species
is: CHEBI:27624
boundary condition: false
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
initial concentration: 1.0
name: prostaglandin-b1
initial amount: NaN
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_0e0605ac_ddea_43e8_92b3_e1142738304e
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:128869
constant: false
is: Q9H490
initial amount: NaN
name: PIGU
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110027#_b92ebf6f_ec01_4e38_abf6_58c67494b9df
is: P03897
constant: false
is: SBO:0000252
is encoded by: hsa:4537
name: ND3
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true

metaR BUTt2r
reversible: true
reactant: MODEL1310110027#
name: Butyrate transport via proton symport, reversible
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110027#_cfb8aeb9_6c7a_469b_9464_1b0fff3d40b6
constant: false
is: SBO:0000252
is: P36969
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:2879
name: GPX4

metaM naglc2p L c
is: CHEBI:18278
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C1160H1898N10O120P20 CHARGE: -20 INCHI: InChI=1S/C33H59NO12P2/c1-23(2)12-8-13-24(3)14-9-15-25(4)16-10-17-26(5)18-11-19-27(6)20-21-43-47(39,40)46-48(41,42)45-33-30(34-28(7)36)32(38)31(37)29(22-35)44-33/h12,14,16,18,27,29-33,35,37-38H,8-11,13,15,17,19-22H2,1-7H3,(H,34,36)(H,39,40)(H,41,42)/b24-14+,25-16+,26-18-/t27?,29-,30-,31-,32-,33-/m1/s1
name: N-Acetyl-D-glucosaminyldiphosphodolichol, human liver homolog
boundary condition: false
initial amount: NaN

metaM L2aadp m
is: CHEBI:58672
constant: false
is: SBO:0000247
boundary condition: false
name: L-2-aminoadipate(1-)
is: HMDB00510
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
has only substance units: false
type: Species

metaM prostgh2 e
initial concentration: 1.0
is: CHEBI:57405
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
is: SBO:0000247
constant: false
type: Species
has only substance units: false
is: HMDB01381
name: prostaglandin H2(1-)

metaR THP2Ctp
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110027#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
reactant: MODEL1310110027#
product: MODEL1310110027#
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate transport, peroxisomal
fast: false
reversible: true

metaM e4p c
has only substance units: false
is: CHEBI:16897
boundary condition: false
constant: false
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
initial amount: NaN
initial concentration: 1.0
is: C00279
type: Species
is: SBO:0000247
name: D-Erythrose 4-phosphate
is: HMDB01321

metaM 1pyr5c c
boundary condition: false
has only substance units: false
name: 1-Pyrroline-5-carboxylate
type: Species
constant: false
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
is: CHEBI:15893
is: SBO:0000247
initial amount: NaN
is: HMDB01301
initial concentration: 1.0
is: C03912

metaR r1654
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110027#
fast: false

metaR PIK3
reversible: false
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.1.137
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5290.1 and 5295.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.3) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5295.2 and 5290.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7628435,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.1.153
modifier: MODEL1310110027#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.154
type: Reaction
kinetic law: MODEL1310110027#
name: phosphatidylinositol 3-kinase
is version of: http://identifiers.org/ec-code/2.7.11.1

http://identifiers.org/biomodels.db/MODEL1310110027#_384657ed_d730_4956_8a98_595f9de0d4a4
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
name: _R51273_1_c
initial amount: NaN
type: Species
is encoded by: hsa:R51273

http://identifiers.org/biomodels.db/MODEL1310110027#_c58a7fa2_e902_4f98_8660_735b15be7557
name: PIK3CG
boundary condition: true
type: Species
is: P48736
initial concentration: NaN
is encoded by: hsa:5294
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_7381d6d4_5052_4ea0_89f0_d198c8cf5588
initial amount: NaN
name: PPT2
type: Species
is: SBO:0000252
is: Q9UMR5
constant: false
is encoded by: hsa:9374
boundary condition: true
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_37d2a313_db7b_424f_a6a8_e6f2d34e3a05
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: _AV713053_1_m
constant: false
is encoded by: hsa:AV713053

metaM c6crn c
type: Species
notes: FORMULA: C13H25NO4 CHARGE: 0
is: HMDB00705
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: hexanoyl carnitine
constant: false
is: SBO:0000247
initial amount: NaN

metaR RE3245C
type: Reaction
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000000
name: RE3245
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton
is: SBO:0000176
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110027#_f3798206_a01c_4804_af51_0f4696aeb915
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:AA278423
is: SBO:0000252
type: Species
initial concentration: NaN
name: _AA278423_1_c
constant: false

metaR r1835
reversible: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
fast: false
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110027#
is: SBO:0000185
reactant: MODEL1310110027#
modifier: MODEL1310110027#

metaM 2mcit c
is: SBO:0000247
boundary condition: false
is: HMDB00379
type: Species
constant: false
initial concentration: 1.0
name: 2-methylcitrate(3-)
initial amount: NaN
has only substance units: false
notes: FORMULA: C7H7O7 CHARGE: -3 INCHI: InChI=1S/C7H10O7/c1-3(5(10)11)7(14,6(12)13)2-4(8)9/h3,14H,2H2,1H3,(H,8,9)(H,10,11)(H,12,13)/p-3
is: CHEBI:15598

metaM hco3 m
constant: false
initial concentration: 1.0
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: C00288
is: CHEBI:17544
boundary condition: false
name: Bicarbonate
is: HMDB00595
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_42448433_9a62_49be_9199_354106b154ea
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
name: GALNT11
is encoded by: hsa:63917
is: B3KWF4
has only substance units: false

metaR r1655
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
fast: false
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110027#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110027#
is described by: ECO:0000000

metaR r0165
kinetic law: MODEL1310110027#
reversible: false
fast: false
product: MODEL1310110027#
name: UTP:pyruvate O2-phosphotransferase EC:2.7.1.40
is: SBO:0000176
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
reactant: MODEL1310110027#
type: Reaction
is described by: ECO:0000000

metaR GHMT2rm
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.1.2.1
modifier: MODEL1310110027#
type: Reaction
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110027#
name: glycine hydroxymethyltransferase, reversible, mitochondrial
notes: GENE_ASSOCIATION: (6472.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
reactant: MODEL1310110027#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110027#_bdd3cac4_6f15_4645_a553_56f323cbaf34
initial concentration: NaN
initial amount: NaN
name: ENTPD1
is encoded by: hsa:953
is: Q86VV3
is: SBO:0000252
constant: false
has only substance units: false
type: Species
boundary condition: true

metaR N3Tg
notes: GENE_ASSOCIATION: (56913.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.122 Confidence Level: 0 AUTHORS: PMID:11677243 NOTES:NCD
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.122
modifier: MODEL1310110027#
type: Reaction
reversible: false
product: MODEL1310110027#
kinetic law: MODEL1310110027#
name: N-acetylgalactosamine 3-beta-galactosyltransferase, Golgi apparatus
is described by: ECO:0000000
reactant: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_c5941906_3fae_45c4_bb1d_2157b68cb7cd
constant: false
is encoded by: hsa:29920
initial concentration: NaN
is: Q96C36
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
name: PYCR2

metaM HC02204 c
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:27624
initial amount: NaN
boundary condition: false
name: prostaglandin-b1
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959

metaM dhap c
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
is: C00111
name: Dihydroxyacetone phosphate
boundary condition: false
is: HMDB01473
is: CHEBI:57642
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/3411

http://identifiers.org/biomodels.db/MODEL1310110027#_2f88a03e_e342_4dc7_84b3_3f3a47d52150
boundary condition: true
name: _AI291895_1_c
is encoded by: hsa:AI291895
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false

metaM h r
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3380
initial amount: NaN
is: CHEBI:24636
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
name: proton
initial concentration: 1.0
is: C00080
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_104e1a02_12ac_4f5f_9762_4bd84eb12aaf
is: SBO:0000252
name: PIGF
constant: false
initial concentration: NaN
is encoded by: hsa:5281
type: Species
is: Q07326
initial amount: NaN
boundary condition: true
has only substance units: false

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

metaR NADPtru
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
is described by: ECO:0000000
kinetic law: MODEL1310110027#
name: NADP transporter, endoplasmic reticulum
product: MODEL1310110027#
reactant: MODEL1310110027#
fast: false
is: SBO:0000185
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_ab4e01b3_26d9_4343_9c33_ea324ae1cb62
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: _642502_1_c
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:642502

http://identifiers.org/biomodels.db/MODEL1310110027#_7bd0a25c_509c_4b4a_8d86_63f857f8ee16
constant: false
is encoded by: hsa:2683
initial concentration: NaN
is: P15291
type: Species
initial amount: NaN
boundary condition: true
name: B4GALT1
is: SBO:0000252
has only substance units: false

metaR CSNAT2x
reversible: true
fast: false
notes: GENE_ASSOCIATION: (54677.1) or (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:15464416,PMID:7829107 NOTES:NJ
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
product: MODEL1310110027#
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
name: carnitine dimethyl nonanoyl transferase, revsible, peroxisomal
is version of: http://identifiers.org/ec-code/2.3.1.7
is version of: http://identifiers.org/ec-code/2.3.1.137
modifier: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_31173f7a_1daf_4125_9548_e2f92afed236
is: P40879
boundary condition: true
constant: false
type: Species
has only substance units: false
name: SLC26A3
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1811

metaM prostgh2 c
is: HMDB01381
initial concentration: 1.0
is: CHEBI:57405
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
name: prostaglandin H2(1-)
type: Species
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_adfd010b_0a84_427a_8630_57b85297cc2c
is: Q86VV3
boundary condition: true
name: ENTPD1
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:953
has only substance units: false
initial amount: NaN
constant: false

metaR FAOXC226C225m
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)m
type: Reaction

metaM tym c
boundary condition: false
is: SBO:0000247
is: CHEBI:327995
name: tyraminium
initial concentration: 1.0
is: HMDB00306
type: Species
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C8H12NO CHARGE: 1 INCHI: InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2/p+1 EHMN_ABBREVIATION: C00483

http://identifiers.org/biomodels.db/MODEL1310110027#_1ddf28cd_20e9_46f2_8bd9_370a8e6df72d
is encoded by: hsa:10423
has only substance units: false
is: SBO:0000252
name: CDIPT
boundary condition: true
is: A8K3L7
initial amount: NaN
constant: false
initial concentration: NaN
type: Species

metaR r1656
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110027#
fast: false
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000

metaM 42A3HP24DB c
boundary condition: false
initial concentration: 1.0
is: C05645
type: Species
is: HMDB04083
notes: FORMULA: C10H8NO5 CHARGE: -1 INCHI: InChI=1/C10H9NO5/c11-9-5(2-1-3-6(9)12)7(13)4-8(14)10(15)16/h1-3,12H,4,11H2,(H,15,16) HEPATONET_1.0_ABBREVIATION: HC01547 EHMN_ABBREVIATION: C05645
initial amount: NaN
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
has only substance units: false
constant: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/7956

metaM 5dhf e
boundary condition: false
initial concentration: 1.0
name: pentaglutamyl folate (DHF)
constant: false
is: SBO:0000247
is: HMDB06487
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
type: Species
has only substance units: false
initial amount: NaN

metaM crn x
is: C00318
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00062
type: Species
is: CHEBI:16347
has only substance units: false
constant: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
name: L-Carnitine
initial amount: NaN

metaM adp c
type: Species
name: ADP
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3310
is: C00008
is: CHEBI:16761
constant: false
boundary condition: false
has only substance units: false
is: HMDB01341
is: SBO:0000247
initial amount: NaN

metaR FAOXC61C4m
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)m
type: Reaction

metaR UDPGALtg
type: Reaction
is described by: ECO:0000269
name: UDP-Gal Golgi transport via CMP antiport
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
product: MODEL1310110027#
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
fast: false
modifier: MODEL1310110027#

metaR P5CR
reactant: MODEL1310110027#
is: SBO:0000176
fast: false
is described by: ECO:0000134
name: pyrroline-5-carboxylate reductase
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 4 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:
type: Reaction
reversible: false
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_44481d21_1a13_4fa5_9b9c_bc5a23499bb9
boundary condition: true
is: SBO:0000252
is encoded by: hsa:26
type: Species
constant: false
initial amount: NaN
has only substance units: false
name: ABP1
is: P19801
initial concentration: NaN

metaR r0817
is: SBO:0000185
fast: false
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
is described by: ECO:0000000
type: Reaction
product: MODEL1310110027#
reversible: true
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.3.1.41
is version of: http://identifiers.org/ec-code/2.3.1.85

metaR 2OXOADPTm
modifier: MODEL1310110027#
is described by: ECO:0000269
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
reactant: MODEL1310110027#
type: Reaction
product: MODEL1310110027#
name: 2-oxoadipate shuttle (cytosol/mitochondria)

metaR PAFt
type: Reaction
product: MODEL1310110027#
fast: false
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110027#
is: SBO:0000185
name: 1-alkyl 2-acteylglycerol 3-phosphocholine transport
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaM em2emgacpail hs r
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol (H7)
initial amount: NaN
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:16038
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
constant: false

metaR EX galside hs LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-galactosyl-N-acylsphingosine exchange
type: Reaction

metaR SUCD1m
is: SBO:0000176
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
product: MODEL1310110027#
reversible: true
is version of: http://identifiers.org/ec-code/1.3.5.1
type: Reaction
modifier: MODEL1310110027#
name: succinate dehydrogenase
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
fast: false

metaM 6htststerone c
is: C14497
boundary condition: false
name: 6 beta hydroxy testosterone
initial amount: NaN
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/17395497
type: Species
has only substance units: false
notes: FORMULA: C19H28O3 CHARGE: 0 INCHI: InChI=1/C19H28O3/c1-18-7-5-11(20)9-15(18)16(21)10-12-13-3-4-17(22)19(13,2)8-6-14(12)18/h9,12-14,16-17,21-22H,3-8,10H2,1-2H3/t12-,13-,14-,16+,17-,18+,19-/m0/s1 EHMN_ABBREVIATION: C14497
is: HMDB06259
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110027#_514572fb_677f_42df_97b1_af9159ae6368
constant: false
name: PIGC
type: Species
is encoded by: hsa:5279
is: Q92535
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR 4NPHSULT
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Cytochrome metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
is: SBO:0000176
type: Reaction
fast: false
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
name: 4-Nitrophenol Sulfotransferase
reversible: false
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.8.2.1
reactant: MODEL1310110027#

metaM 5adtststerones c
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
type: Species
is: HMDB06278
is: SBO:0000247
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
name: 5alpha-Dihydrotestosterone sulfate
initial concentration: 1.0

metaR EX dheas LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dehydroepiandrosterone sulfate exchange
type: Reaction

metaM ocdececrn c
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C25H47NO4 CHARGE: 0
type: Species
has only substance units: false
name: 11-octadecenoyl carnitine
is: HMDB06351

http://identifiers.org/biomodels.db/MODEL1310110027#_deab2081_1413_4ca8_9bac_4a9133c47761
is: SBO:0000252
type: Species
initial concentration: NaN
is: A8K0T6
constant: false
name: SMPD3
boundary condition: true
initial amount: NaN
is encoded by: hsa:55512
has only substance units: false

metaM udpacgal g
is: SBO:0000247
name: UDP-N-acetyl-D-galactosamine(2-)
initial concentration: 1.0
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: HMDB00304
is: CHEBI:57847
boundary condition: false

metaR r2124
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110027#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110027#
kinetic law: MODEL1310110027#
is: SBO:0000185
modifier: MODEL1310110027#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110027#_348feeb7_c0ab_45f3_b03a_a8b96e1305a4
name: PRDX1
has only substance units: false
is encoded by: hsa:5052
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN

metaR LEUGLYPEPT1tc
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylglycine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaR r0752
fast: false
type: Reaction
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
is: SBO:0000176
modifier: MODEL1310110027#
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:

metaR RE2974C
is: SBO:0000176
product: MODEL1310110027#
type: Reaction
fast: false
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.1.149
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (8395.1) or (23396.1) or (5305.1) or (8396.1) or (79837.1) or (8394.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:
reversible: true
is described by: ECO:0000000
name: RE2974
is version of: http://identifiers.org/ec-code/2.7.1.68

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaR DMNONCOACRNCPT1
reactant: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
fast: false
name: DMNONCOACRNCPT1
is described by: ECO:0000000
reversible: true
product: MODEL1310110027#
is: SBO:0000176

metaR S23T3g
is version of: http://identifiers.org/ec-code/2.4.99.6
notes: GENE_ASSOCIATION: (6487.4) or (6487.9) or (6487.11) or (6487.6) or (6487.7) or (6487.10) or (6487.5) or (6487.1) or (6487.2) or (6487.8) or (6487.3) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.6 Confidence Level: 4 AUTHORS: PMID:8333853 NOTES:NCD
product: MODEL1310110027#
type: Reaction
name: beta-galactoside alpha-2,3-sialyltransferase (complex N-glycan)
reversible: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110027#
fast: false
modifier: MODEL1310110027#
reactant: MODEL1310110027#

metaM 3dodtricoa m
initial concentration: 1.0
is: HMDB03952
is: SBO:0000247
name: 3,6,9-dodecatrienoylcoa
type: Species
is: C05280
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C33H48N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110027#_f6028ba4_63b3_42ed_af48_2412c6d3db9a
is: Q06830
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:5052
initial concentration: NaN
name: PRDX1
has only substance units: false
type: Species

metaR FAOXMC10OHMC10r
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(MC10-->w-OHMC10)er
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_a60996d5_6ca0_4ba1_8700_86de7d549c0d
has only substance units: false
type: Species
name: SULT1A3
is encoded by: hsa:6818
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: Q1ET61

http://identifiers.org/biomodels.db/MODEL1310110027#_48f036b1_7eaf_4a3d_bfeb_5567aec4f6b8
initial amount: NaN
name: AK3
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:50808
initial concentration: NaN
is: SBO:0000252
is: E7ET30
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_9d3909d5_16d5_4e12_9e27_60cb44aa5af7
initial concentration: NaN
constant: false
is: P32929
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:1491
boundary condition: true
name: CTH
is: SBO:0000252

metaR PHEMEt
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (113235.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:16143108 NOTES:NCD
name: heme transport
product: MODEL1310110027#
fast: false
modifier: MODEL1310110027#
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110027#
reversible: false

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

metaM retinal cis 13 r
is: SBO:0000247
constant: false
is: HMDB06220
has only substance units: false
type: Species
name: 13-cis-retinal
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
boundary condition: false
initial concentration: 1.0
is: CHEBI:45487
initial amount: NaN

metaM 2mcit e
initial amount: NaN
is: CHEBI:15598
notes: FORMULA: C7H7O7 CHARGE: -3 INCHI: InChI=1S/C7H10O7/c1-3(5(10)11)7(14,6(12)13)2-4(8)9/h3,14H,2H2,1H3,(H,8,9)(H,10,11)(H,12,13)/p-3
name: 2-methylcitrate(3-)
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB00379
boundary condition: false
has only substance units: false

metaR r1544
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110027#
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110027#
is: SBO:0000185
fast: false
type: Reaction

metaM ksi pre12 g
type: Species
is: CHEBI:58053
notes: FORMULA: C135H218N9O106S3X CHARGE: -4
boundary condition: false
is: HMDB00175
has only substance units: false
constant: false
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 12
is: C00130
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_4b10e2b0_9b66_4fa6_a4b0_8bfdcc8ccc05
boundary condition: true
is encoded by: hsa:AL050025
constant: false
type: Species
has only substance units: false
name: _AL050025_1_c
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110027#_4a0ec949_08ec_4b7f_8514_6f70f640182b
name: NDUFB5
boundary condition: true
initial concentration: NaN
is: O43674
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:4711
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_b1cef3ab_be67_4501_a587_c568891d9272
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:2629
is: B7Z6S1
name: GBA
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true

metaM pail345p hs c
type: Species
constant: false
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981
boundary condition: false
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
is: SBO:0000247
initial amount: NaN
is: CHEBI:57836
initial concentration: 1.0

metaM hista c
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: histamium
is: CHEBI:58432
is: HMDB00870

http://identifiers.org/biomodels.db/MODEL1310110027#_a4586416_fb5e_48b9_b11c_d2dc0660002e
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:8875
is: A8K7W0
name: VNN2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_d0fd622c_854c_40a7_b502_16eb33189516
name: PIP5K1C
constant: false
boundary condition: true
is: O60331
has only substance units: false
is encoded by: hsa:23396
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species

metaR r2125
is: SBO:0000185
reactant: MODEL1310110027#
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110027#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110027#
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110027#_7bf7d1d4_9a30_4e33_9265_9ead91428d17
type: Species
is: SBO:0000252
initial concentration: NaN
name: ME2
has only substance units: false
constant: false
is: P23368
initial amount: NaN
boundary condition: true
is encoded by: hsa:4200

metaR PRPNCOAHYDm
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/4.2.1.18
is described by: ECO:0000134
name: Propenoyl-CoA hydrolase (m)
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
reactant: MODEL1310110027#

metaM fuc1p L c
type: Species
constant: false
is: HMDB01265
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:28319
name: L-Fucose 1-phosphate
notes: FORMULA: C6H11O8P CHARGE: -2 INCHI: InChI=1S/C6H13O8P/c1-2-3(7)4(8)5(9)6(13-2)14-15(10,11)12/h2-9H,1H3,(H2,10,11,12)/t2-,3+,4+,5-,6?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01030
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110027#_0e44e232_7c27_48ea_b9bc_7cc8faa3acd5
constant: false
boundary condition: true
is: SBO:0000252
type: Species
is: Q86SK9
name: SCD5
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:79966

metaM gal l
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124
constant: false
name: D-galactose
is: SBO:0000247
is: HMDB00143
type: Species
initial amount: NaN
is: CHEBI:12936

metaR DESAT20 2
reactant: MODEL1310110027#
name: fatty acyl-CoA desaturase (n-C20:4CoA -> n-C20:5CoA)
is described by: ECO:0000000
kinetic law: MODEL1310110027#
fast: false
is: SBO:0000176
modifier: MODEL1310110027#
product: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110027#_3ec2f1f6_2d53_4756_84a9_6a6a9fde8f23
has only substance units: false
constant: false
is: P14060
is: SBO:0000252
is encoded by: hsa:3283
initial concentration: NaN
name: HSD3B1
boundary condition: true
initial amount: NaN
type: Species

metaM glyald m
has only substance units: false
is: HMDB01051
is: CHEBI:17378
type: Species
is: SBO:0000247
name: D-glyceraldehyde
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaR r0753
is described by: ECO:0000000
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
fast: false
is: SBO:0000176
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
product: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true

metaM nadph r
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
name: Nicotinamide adenine dinucleotide phosphate - reduced
constant: false
initial concentration: 1.0
is: CHEBI:57783
type: Species
is: SBO:0000247
has only substance units: false
is: C00005
initial amount: NaN
boundary condition: false
is: HMDB00221

metaM focytC m
initial concentration: 1.0
constant: false
is: CHEBI:16928
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
name: Ferrocytochrome C

metaR ALAGLNexR
product: MODEL1310110027#
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
is described by: ECO:0000304
reversible: true
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
name: L-alanine/glutamine reversible exchange

metaR ASNGLNNaEx
type: Reaction
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110027#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110027#
reversible: false
is described by: ECO:0000269
name: L-glutamine/L-asparagine Na-dependent exchange (Asn-L in)
reactant: MODEL1310110027#

metaM fe2 c
is: CHEBI:29033
has only substance units: false
is: C00023
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
name: Fe2+
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB00692

metaR r1650
is described by: ECO:0000000
product: MODEL1310110027#
modifier: MODEL1310110027#
reactant: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110027#
type: Reaction
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110027#_d5cbc37d_d29e_4db5_bbf7_ec5329dc4c8c
is encoded by: hsa:1350
name: COX7C
has only substance units: false
is: P15954
constant: false
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252

metaR r2126
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
product: MODEL1310110027#
kinetic law: MODEL1310110027#
fast: false
modifier: MODEL1310110027#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110027#

metaR PROD2
name: Proline dehydrogenase
fast: false
is: SBO:0000176
modifier: MODEL1310110027#
is described by: ECO:0000254
type: Reaction
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (58510.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR
product: MODEL1310110027#
kinetic law: MODEL1310110027#
reversible: false
is version of: http://identifiers.org/ec-code/1.5.99.8

metaR SERDGLYexR
fast: false
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110027#
type: Reaction
reversible: true
product: MODEL1310110027#
name: D-Serine/Glycine reversible exchange
is described by: ECO:0000304
reactant: MODEL1310110027#
modifier: MODEL1310110027#
is: SBO:0000185

metaR EX HC02204 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b1 exchange
type: Reaction

metaM xoltri27 c
constant: false
has only substance units: false
is: CHEBI:18431
type: Species
name: 7alpha,26-dihydroxycholesterol
initial amount: NaN
is: HMDB06281
initial concentration: 1.0
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h15,17-18,20-25,28-30H,5-14,16H2,1-4H3/t17?,18-,20+,21-,22+,23+,24-,25+,26+,27-/m1/s1
boundary condition: false
is: SBO:0000247

metaM h e
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:24636
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3380
initial amount: NaN
name: proton
has only substance units: false
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: "
is: C00080

metaM L2aadp c
type: Species
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB00510
is: SBO:0000247
is: CHEBI:58672
initial concentration: 1.0
name: L-2-aminoadipate(1-)

metaR CRNt
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
is: SBO:0000185
type: Reaction
name: L-carnitine reversible transport
reactant: MODEL1310110027#
fast: false
product: MODEL1310110027#

metaM ksi pre6 g
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB00175
constant: false
name: keratan sulfate I biosynthesis, precursor 6
is: C00130
is: CHEBI:58053
notes: FORMULA: C107H174N7O80SX CHARGE: -2
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110027#_c8932597_6038_4005_b9fd_b7404e413225
boundary condition: true
initial concentration: NaN
is: Q9BV79
name: MECR
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:51102
type: Species
initial amount: NaN

metaR r1546
reactant: MODEL1310110027#
is described by: ECO:0000000
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110027#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110027#_4de4a014_d330_4ecf_9eb9_b579692aa7a9
boundary condition: true
is: E9PDD5
name: IDH3G
is encoded by: hsa:3421
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_5762bdb1_bbc9_4509_8fc3_4b737f25d55f
initial amount: NaN
boundary condition: true
constant: false
name: AMPD3
is: B7Z763
type: Species
is: SBO:0000252
is encoded by: hsa:272
initial concentration: NaN
has only substance units: false

metaR r1651
product: MODEL1310110027#
is: SBO:0000185
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
reversible: true
modifier: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

metaR r2127
reversible: true
reactant: MODEL1310110027#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110027#
product: MODEL1310110027#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
kinetic law: MODEL1310110027#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110027#_dea9317e_e185_4777_91f5_889547364ae7
boundary condition: true
initial amount: NaN
is encoded by: hsa:5742
name: PTGS1
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
is: P23219
constant: false

metaR GARFT
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110027#
type: Reaction
fast: false
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
name: phosphoribosylglycinamide formyltransferase
is version of: http://identifiers.org/ec-code/2.1.2.2
product: MODEL1310110027#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.2 Confidence Level: 4 AUTHORS: PMID:12450384,PMID:2183217,PMID:9328467,PMID:9473452 NOTES:

metaR EX inost LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: myo-Inositol exchange
type: Reaction

metaM h g
initial concentration: 1.0
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
name: proton
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:24636
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_be53c49c_ef93_49e7_8e9a_1f101ca18c9e
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: Q7LBE3
name: SLC26A9
is encoded by: hsa:115019
constant: false
initial amount: NaN
has only substance units: false
type: Species

metaR r1547
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
product: MODEL1310110027#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110027#
is described by: ECO:0000000

metaR r1652
is described by: ECO:0000000
reactant: MODEL1310110027#
product: MODEL1310110027#
fast: false
modifier: MODEL1310110027#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110027#
reversible: true

metaM ksii core4 pre6 g
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28067
notes: FORMULA: C69H111N6O51SX CHARGE: -2
name: keratan sulfate II biosynthesis, precursor 6

metaR r2341
fast: false
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
reversible: true

metaR r2120
modifier: MODEL1310110027#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110027#
fast: false
kinetic law: MODEL1310110027#
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110027#
is: SBO:0000185

metaM r1p c
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
name: alpha-D-Ribose 1-phosphate
is: CHEBI:57720
constant: false
is: HMDB01489
is: C00442
initial amount: NaN
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_a87aa993_0845_4343_8633_330bff59a7af
name: NDUFA8
initial amount: NaN
type: Species
is: B1AM93
initial concentration: NaN
is encoded by: hsa:4702
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true

metaM 1pyr5c m
constant: false
initial concentration: 1.0
name: 1-Pyrroline-5-carboxylate
initial amount: NaN
is: C03912
is: SBO:0000247
is: CHEBI:15893
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
has only substance units: false
is: HMDB01301
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_7ab4123c_ead5_43de_ad96_6afc7a688ede
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:6391
boundary condition: true
initial amount: NaN
is: Q99643
name: SDHC
initial concentration: NaN
has only substance units: false

metaM xoltri27 e
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB06281
name: 7alpha,26-dihydroxycholesterol
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h15,17-18,20-25,28-30H,5-14,16H2,1-4H3/t17?,18-,20+,21-,22+,23+,24-,25+,26+,27-/m1/s1
constant: false
initial concentration: 1.0
is: CHEBI:18431

http://identifiers.org/biomodels.db/MODEL1310110027#_868f029d_de49_40b0_baff_18ff944ba132
is: SBO:0000252
name: PLA2G2A
is encoded by: hsa:5320
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
is: P14555
constant: false
boundary condition: true

metaR r1548
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
fast: false
kinetic law: MODEL1310110027#
type: Reaction
product: MODEL1310110027#
reversible: true
reactant: MODEL1310110027#

metaR LYStm
reactant: MODEL1310110027#
modifier: MODEL1310110027#
reversible: true
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110027#
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is described by: ECO:0000269
name: Lysine mitochondrial transport via ornithine carrier

metaM ksi pre27 g
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58053
has only substance units: false
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 27
type: Species
notes: FORMULA: C205H328N14O171S8X CHARGE: -9
is: C00130
constant: false
is: HMDB00175

metaM 5dhf l
is: HMDB06487
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
initial amount: NaN
constant: false
has only substance units: false
name: pentaglutamyl folate (DHF)
type: Species

metaM HC02216 c
initial amount: NaN
name: prostaglandin-f2beta
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:28922
initial concentration: 1.0
constant: false

metaM ocdececrn m
initial amount: NaN
has only substance units: false
constant: false
name: 11-octadecenoyl carnitine
boundary condition: false
is: HMDB06351
initial concentration: 1.0
notes: FORMULA: C25H47NO4 CHARGE: 0
type: Species
is: SBO:0000247

metaM h l
has only substance units: false
initial concentration: 1.0
is: CHEBI:24636
boundary condition: false
type: Species
initial amount: NaN
name: proton
constant: false
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: "
is: http://identifiers.org/pubchem.compound/3380
is: C00080

metaM HC01405 m
name: (S)-Hydroxyoctanoyl-CoA
boundary condition: false
is: CHEBI:28632
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266

http://identifiers.org/biomodels.db/MODEL1310110027#_85351e36_e32e_4177_97a8_beb4cbe1ed0a
is encoded by: hsa:4129
boundary condition: true
is: P27338
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
name: MAOB
type: Species
initial amount: NaN

metaM dhap m
type: Species
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/3411
is: C00111
has only substance units: false
initial concentration: 1.0
name: Dihydroxyacetone phosphate
is: HMDB01473
boundary condition: false
initial amount: NaN

metaM hLkynr c
has only substance units: false
is: CHEBI:17380
boundary condition: false
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227
is: SBO:0000247
constant: false
is: HMDB11631
name: 3-hydroxy-L-kynurenine
initial amount: NaN
initial concentration: 1.0
type: Species

metaM ocdca e
has only substance units: false
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
name: octadecanoate (n-C18:0)
is: C01530
is: CHEBI:25629
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB00827
type: Species
initial amount: NaN
initial concentration: 1.0

metaM glyc R m
is: HMDB00139
is: CHEBI:16659
boundary condition: false
name: D-glycerate
initial concentration: 1.0
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247

metaM m7masnC g
initial amount: NaN
constant: false
is: CHEBI:58433
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform C (protein)
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C64H107N2O50X CHARGE: 0
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB02985

metaR r2121
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110027#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110027#
reversible: true
product: MODEL1310110027#
modifier: MODEL1310110027#
fast: false

metaM udpacgal l
type: Species
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB00304
name: UDP-N-acetyl-D-galactosamine(2-)
initial amount: NaN
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
initial concentration: 1.0
is: CHEBI:57847
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_2beda244_6167_4b72_8039_549311a24455
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:8803
type: Species
boundary condition: true
constant: false
has only substance units: false
is: E5KS60
name: SUCLA2
initial amount: NaN

metaM crn m
boundary condition: false
has only substance units: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
type: Species
is: CHEBI:16347
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB00062
is: C00318
name: L-Carnitine

http://identifiers.org/biomodels.db/MODEL1310110027#_2b3ef1f9_15e2_4011_8f06_b886c2908ef7
is encoded by: hsa:1718
type: Species
boundary condition: true
name: DHCR24
has only substance units: false
is: SBO:0000252
constant: false
is: Q15392
initial amount: NaN
initial concentration: NaN

metaM g3m8masn r
type: Species
notes: FORMULA: C88H147N2O70X CHARGE: 0
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
is: C05873
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)

metaR r1549
is described by: ECO:0000000
kinetic law: MODEL1310110027#
type: Reaction
product: MODEL1310110027#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185
reactant: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM ksii core2 deg3 l
name: keratan sulfate II (core 2-linked), degradation product 3
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:12936
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C58H94N5O46S2X CHARGE: -2
is: HMDB00143

metaR ACACT7p
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000269
reactant: MODEL1310110027#
modifier: MODEL1310110027#
reversible: false
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
is: SBO:0000176
name: acetyl-CoA acyltransferase (tetradecanoyl-CoA), peroxisomal
product: MODEL1310110027#
fast: false
kinetic law: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_c2619f41_8f01_40dc_a339_d2d849d30f4c
has only substance units: false
is: P23921
is encoded by: hsa:6240
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: RRM1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_1e09fb17_9a5b_4073_bc02_61a5081c596d
has only substance units: false
is: Q9NRR6
constant: false
name: INPP5E
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:56623
type: Species
initial amount: NaN

metaM h m
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3380
is: C00080
name: proton
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:24636
type: Species

metaR G14T13g
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reversible: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
product: MODEL1310110027#
kinetic law: MODEL1310110027#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
modifier: MODEL1310110027#

metaM odecoa c
constant: false
initial amount: NaN
is: CHEBI:3793
type: Species
name: Octadecenoyl-CoA (n-C18:1CoA)
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB01322
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110027#_b8d43d37_7c85_4477_8e87_34925c17e359
name: SLC6A4
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
is: P31645
is encoded by: hsa:6532
initial amount: NaN
has only substance units: false
boundary condition: true

metaR FUCtly
name: L-fucose efflux from lysosome
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:
product: MODEL1310110027#
reactant: MODEL1310110027#
type: Reaction

metaR DCSPTN1CPT2
is: SBO:0000176
name: carnitine transferase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
product: MODEL1310110027#
reactant: MODEL1310110027#
fast: false
reversible: false

metaR r2343
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110027#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110027#
type: Reaction
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_fd370298_5f44_457d_a521_143e381b6009
constant: false
is encoded by: hsa:D29675
type: Species
boundary condition: true
initial amount: NaN
name: _D29675_1_c
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR PI345P3P
reversible: false
name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.1.3.67
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (5728.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 4 AUTHORS: PMID:11463863 NOTES:NCD
kinetic law: MODEL1310110027#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110027#
reactant: MODEL1310110027#

metaR r2122
reactant: MODEL1310110027#
modifier: MODEL1310110027#
fast: false
type: Reaction
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
kinetic law: MODEL1310110027#
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110027#_e5b3fbd9_3097_4c4f_ad17_dd6a11fd4dc0
is: SBO:0000252
type: Species
is encoded by: hsa:54677
initial concentration: NaN
has only substance units: false
is: E7EQF2
constant: false
name: CROT
boundary condition: true
initial amount: NaN

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

metaR r0539
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.1.1.34
product: MODEL1310110027#
is: SBO:0000176
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:
kinetic law: MODEL1310110027#
name: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19

metaM ksii core2 l
name: keratan sulfate II (core 2-linked)
is: HMDB01014
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:57255

metaR RTOTAL3t
is described by: ECO:0000000
name: RTOTAL3 transport
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
reversible: true
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
fast: false
type: Reaction
is: SBO:0000185

metaR ACNAMlt
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ
is described by: ECO:0000269
type: Reaction
product: MODEL1310110027#
modifier: MODEL1310110027#
fast: false
reactant: MODEL1310110027#
name: N-acetylneuraminate transport into lysososme
is: SBO:0000185
kinetic law: MODEL1310110027#
reversible: true

metaR RE1531M
kinetic law: MODEL1310110027#
name: RE1531
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
modifier: MODEL1310110027#
reactant: MODEL1310110027#
type: Reaction
fast: false
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_b8b75240_4e54_4342_b5b4_32297e65e593
constant: false
name: CYP27A1
is: Q02318
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:1593
is: SBO:0000252
has only substance units: false
type: Species

metaM gly e
boundary condition: false
is: HMDB00123
has only substance units: false
is: C00037
initial concentration: 1.0
type: Species
is: CHEBI:3339
name: Glycine
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C2H5NO2 CHARGE: 0

metaR PI45P3K
reversible: false
name: phosphatidylinositol 4,5-bisphosphate 3-kinase
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.1.153
type: Reaction
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.11.1
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5293.1 and 8503.1) or (5296.1 and 5290.1) or (5293.1 and 5295.1) or (5293.1 and 5295.3) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (5295.2 and 5290.1) or (10870.1 and 5294.1) or (23533.1 and 5294.1) or (5295.2 and 5293.1) or (5290.1 and 5295.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (5291.1 and 8503.1) or (5293.1 and 5296.1) or (5295.2 and 5291.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.153 Confidence Level: 4 AUTHORS: PMID:12507995,PMID:15780590,PMID:2174051,PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989 NOTES:NCD
product: MODEL1310110027#
is: SBO:0000176
is described by: ECO:0000000
fast: false
modifier: MODEL1310110027#

metaR r2344
reactant: MODEL1310110027#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110027#
name: Organic anion transporter 5 Utilized transport
type: Reaction
is: SBO:0000185
product: MODEL1310110027#
fast: false

metaR AG13T5g
is described by: ECO:0000000
reactant: MODEL1310110027#
fast: false
is: SBO:0000176
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction
modifier: MODEL1310110027#
product: MODEL1310110027#
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false

metaR GMAND
is described by: ECO:0000000
fast: false
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
type: Reaction
name: GDP-D-mannose dehydratase
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (2762.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.2.1.47 Confidence Level: 0 AUTHORS: NOTES:JLR
is version of: http://identifiers.org/ec-code/4.2.1.47
product: MODEL1310110027#

metaR GMPtg
fast: false
product: MODEL1310110027#
reversible: true
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:
name: GMP transport (Golgi)

metaR C4DCCACT
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinyl carnitine into cytosol
type: Reaction

metaM dece4coa m
is: HMDB02145
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
name: 4-decenoylcoa

http://identifiers.org/biomodels.db/MODEL1310110027#_9c1ff0f1_b5a5_422e_aa4a_37e904d6728d
boundary condition: true
constant: false
name: PIP4K2A
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:5305
is: P48426
has only substance units: false

metaR r2123
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110027#
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110027#
fast: false
modifier: MODEL1310110027#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110027#

metaR FADH2ETC
name: Complex II reaction for respiratory chain
reactant: MODEL1310110027#
reversible: false
is described by: ECO:0000134
product: MODEL1310110027#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction

metaM CE5118 m
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,12-15,22-24,28-30,34,45-46H,4-7,10-11,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,13-12-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5118
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:57923
has only substance units: false
constant: false
initial amount: NaN
name: trans-2-cis,cis-4,8-tetradecatrienoyl-CoA

metaM hista e
name: histamium
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
is: SBO:0000247
type: Species
is: CHEBI:58432
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
is: HMDB00870

metaR HSD17B2r
reactant: MODEL1310110027#
name: 17-beta-hydroxysteroid dehydrogenase
product: MODEL1310110027#
kinetic law: MODEL1310110027#
reversible: false
modifier: MODEL1310110027#
fast: false
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (3294.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.62 Confidence Level: 4 AUTHORS: PMID:8099587 NOTES:microsomal NAD as cofactor HSD type 2 recheck/confirm comparmentalization - type 1: cytosol, types 2,3: microsomes NJ
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.62

metaM tchola x
boundary condition: false
type: Species
constant: false
is: HMDB00036
initial concentration: 1.0
is: SBO:0000247
name: taurocholate
initial amount: NaN
is: CHEBI:36257
has only substance units: false
notes: FORMULA: C26H45NO7S CHARGE: 0 INCHI: InChI=1S/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122

metaR DHAPtc
reversible: false
name: transport of DHAP into cytosol
is: SBO:0000185
type: Reaction
reactant: MODEL1310110027#
fast: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110027#
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_2b4ee137_b5a1_4235_8582_7dd26919070b
type: Species
initial concentration: NaN
is encoded by: hsa:954
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: ENTPD2
is: Q5SPY7

http://identifiers.org/biomodels.db/MODEL1310110027#_d95681ed_75ad_40ab_807a_7077d546660f
initial concentration: NaN
type: Species
is: E9PB82
has only substance units: false
name: HSD17B4
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:3295

http://identifiers.org/biomodels.db/MODEL1310110027#_d8eba32d_03d4_4081_90cf_c7ba29a1568e
is encoded by: hsa:AI653169
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
name: _AI653169_1_c

metaR FAOXC102C101m
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: reduction(C10:2-->C10:1)m
type: Reaction

metaM c226coa x
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
constant: false
is: SBO:0000247
boundary condition: false
is: C16169
type: Species
name: cervonyl coenzyme A
is: http://identifiers.org/pubchem.compound/47205479
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaM doldp L r
is: CHEBI:15750
has only substance units: false
constant: false
name: Dolichol diphosphate, human liver homolog
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C1080H1758O70P20 CHARGE: -30 INCHI: InChI=1S/C25H46O7P2/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-31-34(29,30)32-33(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H,29,30)(H2,26,27,28)/b22-13+,23-15+,24-17-
type: Species
initial concentration: 1.0
boundary condition: false

metaM fe2 e
is: HMDB00692
is: CHEBI:29033
initial amount: NaN
constant: false
is: C00023
type: Species
has only substance units: false
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
is: SBO:0000247
name: Fe2+
boundary condition: false
initial concentration: 1.0

metaR CAATPS
fast: false
reversible: false
kinetic law: MODEL1310110027#
is: SBO:0000185
reactant: MODEL1310110027#
modifier: MODEL1310110027#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (492.1) or (491.1) or (490.1) or (493.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.6 Confidence Level: 4 AUTHORS: PMID:7876199,PMID:8396145 NOTES:plasma membrane version (SR and ER versions also exist) stoichiometry actually varies (number of Ca/ATP transported). See PMID: 7876199 NJ
name: Ca ATPase
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.6.3.8

http://identifiers.org/biomodels.db/MODEL1310110027#_4a7a9af6_07f7_4079_b8c9_ce4793261b71
type: Species
boundary condition: true
is encoded by: hsa:4712
has only substance units: false
is: O95139
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
name: NDUFB6

metaM 5dhf m
name: pentaglutamyl folate (DHF)
constant: false
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB06487
initial concentration: 1.0

metaR CRNtx
name: carnitine transport peroxisome to mitochondria
is: SBO:0000185
is described by: ECO:0000000
reversible: true
product: MODEL1310110027#
reactant: MODEL1310110027#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12814641,PMID:15464416 NOTES:mechanism not currently elucidated NJ
kinetic law: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_6201ecae_ffa0_4635_a6d5_b350cd6272a6
is encoded by: hsa:8526
constant: false
has only substance units: false
is: A1L4Q0
name: DGKE
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110027#_592607ff_0e78_4b52_95ec_6bbc024d72c4
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
name: PRDX3
is encoded by: hsa:10935
type: Species
is: P30048
is: SBO:0000252

metaM ile L m
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17191
has only substance units: false
constant: false
is: HMDB00172
boundary condition: false
is: SBO:0000247
name: L-isoleucine
type: Species

metaR RE0830N
fast: false
type: Reaction
is described by: ECO:0000000
name: RE0830
product: MODEL1310110027#
is: SBO:0000176
reversible: true
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/4.2.1.96
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
kinetic law: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_8846fe6b_ccd3_4072_bfc0_7a870a433070
initial concentration: NaN
boundary condition: true
has part: O95497
is encoded by: hsa:8875
initial amount: NaN
has only substance units: false
name: VNN3:VNN2:VNN1
is encoded by: hsa:8876
has part: A8K7W0
is encoded by: hsa:55350
constant: false
is: SBO:0000297
type: Species

metaR r2398
product: MODEL1310110027#
kinetic law: MODEL1310110027#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110027#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

metaR CYTK3
reactant: MODEL1310110027#
name: cytidylate kinase (CMP)(GTP)
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
type: Reaction
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.4.3
modifier: MODEL1310110027#
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110027#
is: SBO:0000176
fast: false

metaR LACLt
reversible: false
kinetic law: MODEL1310110027#
name: Lactate transport
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMCID: PMC1820816. NOTES:for regeneration of nad in peroxisomes, for providing nad to the beta oxidation
is: SBO:0000185
type: Reaction
reactant: MODEL1310110027#
fast: false
product: MODEL1310110027#

metaR r2347
reversible: true
product: MODEL1310110027#
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000000
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
fast: false

metaR r1051
kinetic law: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110027#
is described by: ECO:0000000
name: Vesicular transport
product: MODEL1310110027#

metaM cgly c
initial amount: NaN
name: L-cysteinylglycine
is: SBO:0000247
is: HMDB00078
is: CHEBI:4047
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
type: Species

metaR C6CRNe
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of hexanoyl carnitine into the extra cellular fluid
type: Reaction

metaM ksi pre32 g
initial concentration: 1.0
initial amount: NaN
is: CHEBI:28067
type: Species
name: keratan sulfate I biosynthesis, precursor 32
boundary condition: false
is: SBO:0000247
notes: FORMULA: C227H362N16O192S10X CHARGE: -11
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_f75e78a4_6cd4_4b39_9e34_b9afa64e2e54
is: SBO:0000252
has only substance units: false
is: Q9NSW9
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6553
constant: false
type: Species
initial amount: NaN
name: SLC9A5

metaR ASNCYSNaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110027#
is: SBO:0000185
reactant: MODEL1310110027#
name: L-cysteine/L-asparagine Na-dependent exchange (Asn-L in)
product: MODEL1310110027#
is described by: ECO:0000269
reversible: false
fast: false
type: Reaction
modifier: MODEL1310110027#

metaR AG13T18g
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110027#
fast: false
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction

metaM chlstol r
is: HMDB06842
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
name: 5alpha-cholesta-7,24-dien-3beta-ol
is: CHEBI:16290

metaM C05279 m
is: HMDB11123
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
is: CHEBI:28387
name: trans,cis-Lauro-2,6-dienoyl-CoA
type: Species
constant: false
initial concentration: 1.0
has only substance units: false

metaR H2Otp
name: H2O transport, peroxisomal
fast: false
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
kinetic law: MODEL1310110027#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110027#
reversible: true

metaM 2docohexecoa m
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
is: HMDB02288
is: SBO:0000247
initial amount: NaN
name: 2,7,10,13,16,19-docosahexenoylcoa
boundary condition: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4

metaR CYTK4
modifier: MODEL1310110027#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
name: cytidylate kinase (dCMP)(GTP)
reversible: true
kinetic law: MODEL1310110027#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.3
reactant: MODEL1310110027#
type: Reaction
product: MODEL1310110027#

metaR DCMPDA
is version of: http://identifiers.org/ec-code/3.5.4.12
modifier: MODEL1310110027#
reversible: true
name: dCMP deaminase
fast: false
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is: SBO:0000176
is described by: ECO:0000254
type: Reaction

metaR r2346
name: Organic anion transporter 5 Utilized transport
reversible: true
reactant: MODEL1310110027#
is described by: ECO:0000000
product: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
fast: false
kinetic law: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_ba4ad5ba_85f8_4d25_93c5_5568b7d3657f
is: SBO:0000252
initial concentration: NaN
name: NDUFA2
boundary condition: true
constant: false
is: O43678
is encoded by: hsa:4695
type: Species
initial amount: NaN
has only substance units: false

metaR MI13PP
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.64 Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
reactant: MODEL1310110027#
reversible: false
name: inositol-1,3-bisphosphate 3-phosphatase
type: Reaction
product: MODEL1310110027#
is: SBO:0000176

metaM k c
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
type: Species
is: C00238
constant: false
is: CHEBI:29103
has only substance units: false
initial concentration: 1.0
name: potassium
is: HMDB00586

http://identifiers.org/biomodels.db/MODEL1310110027#_ae55ea5e_6ffc_4ab2_983f_093353cc70c0
initial concentration: NaN
boundary condition: true
name: ALDH3B2
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:222
is: P48448

metaM 3octdectecoa m
initial concentration: 1.0
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
has only substance units: false
is: HMDB02288
constant: false
name: 3,6,9,12-octadecatetraenoylcoa
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species

metaM prostgh2 r
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
initial amount: NaN
name: prostaglandin H2(1-)
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
is: HMDB01381
is: CHEBI:57405
has only substance units: false

metaR ADKd
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110027#
product: MODEL1310110027#
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)
is version of: http://identifiers.org/ec-code/2.7.4.3
reactant: MODEL1310110027#
modifier: MODEL1310110027#
name: adenylate kinase (d form)

metaR LDH D
is: SBO:0000176
fast: false
modifier: MODEL1310110027#
reactant: MODEL1310110027#
type: Reaction
product: MODEL1310110027#
name: D-lactate dehydrogenase
reversible: true
is version of: http://identifiers.org/ec-code/1.1.2.4
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)
is described by: ECO:0000304

metaR r1431
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
name: 2-Deoxyuridine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Pyrimidine metabolism EC:1.17.4.1
is: SBO:0000176
reactant: MODEL1310110027#
reversible: false
fast: false
kinetic law: MODEL1310110027#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110027#

metaM nh4 c
is: SBO:0000247
is: HMDB00051
is: C01342
initial concentration: 1.0
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
name: Ammonium
is: CHEBI:28938
boundary condition: false
constant: false
type: Species
initial amount: NaN
has only substance units: false

metaM CE0785 m
is: CHEBI:57795
is: SBO:0000247
initial amount: NaN
name: cis,cis-myristo-5,8-dienoyl-CoA
initial concentration: 1.0
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
boundary condition: false
has only substance units: false
constant: false
type: Species

metaM lac D e
is: CHEBI:16004
constant: false
is: HMDB01311
type: Species
is: SBO:0000247
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
name: (R)-lactate
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaM retinal cis 9 r
is: CHEBI:17898
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
boundary condition: false
is: HMDB01358
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: all-trans-retinal
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_40525558_be93_4c8e_975f_3b46aafb670e
boundary condition: true
is: Q96QD8
initial amount: NaN
name: SLC38A2
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:54407
constant: false

metaR r0545
is: SBO:0000176
is described by: ECO:0000000
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
kinetic law: MODEL1310110027#
product: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.6.1.5
reactant: MODEL1310110027#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110027#_024a9766_c4b3_4285_9eae_fd5ed1aac7c5
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5334
is: Q15111
initial concentration: NaN
type: Species
name: PLCL1
initial amount: NaN
constant: false

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_7ab204e4_6d5c_4f2c_9ed2_125cf604733d
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
name: _T83654_1_c
is encoded by: hsa:T83654
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_2d08c963_6ebd_4c35_bf63_14b1b5a374f1
boundary condition: true
is: SBO:0000252
is: O75038
is encoded by: hsa:9651
initial amount: NaN
has only substance units: false
name: PLCH2
initial concentration: NaN
constant: false
type: Species

metaR EX fe3 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Fe3+ exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_87892deb_8908_4b46_9ff7_8e743f88640c
name: AACS
constant: false
is: Q86V21
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:65985
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_661e74b6_9500_47dc_b83b_6869e3843353
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is: E2QC23
initial amount: NaN
name: GCAT
is encoded by: hsa:23464

http://identifiers.org/biomodels.db/MODEL1310110027#_8176ed0e_ca5e_477d_8115_eeb8d0597e86
boundary condition: true
is: P24752
type: Species
name: ACAT1
has only substance units: false
initial concentration: NaN
is encoded by: hsa:38
is: SBO:0000252
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_af0b8bdd_9fdd_4103_8f53_55bc88b35965
is encoded by: hsa:285973
has only substance units: false
initial concentration: NaN
type: Species
is: Q674R7
constant: false
is: SBO:0000252
initial amount: NaN
name: ATG9B
boundary condition: true

metaM chol e
name: Choline
is: CHEBI:15354
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: HMDB00097
initial amount: NaN
initial concentration: 1.0
type: Species
is: C00114
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_ec65c9f9_7232_482a_9445_c7bf11941126
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is: Q16790
name: CA9
type: Species
is: SBO:0000252
is encoded by: hsa:768
initial amount: NaN

metaR CYTK1
modifier: MODEL1310110027#
is: SBO:0000176
reactant: MODEL1310110027#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
fast: false
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110027#
name: cytidylate kinase (CMP)

metaR ALASERNaEx
modifier: MODEL1310110027#
name: L-alanine/L-serine Na-dependent exchange (Ala-L in)
is: SBO:0000185
reversible: false
fast: false
is described by: ECO:0000269
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
product: MODEL1310110027#

metaR ACACT1rm
name: acetyl-CoA C-acetyltransferase, mitochondrial
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV
is version of: http://identifiers.org/ec-code/2.3.1.9
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110027#_3c57138e_b1a7_41bf_87ae_db0f2f6f12eb
constant: false
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
name: DHFR
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1719
is: P00374

metaM acgam r
constant: false
name: N-acetyl-D-glucosamine
is: CHEBI:17411
initial concentration: 1.0
is: HMDB00215
is: SBO:0000247
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false

metaM pristcoa c
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:51341
name: pristanoyl coa
initial amount: NaN
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_4719f0d0_2997_46cd_9e10_1e2d34aca13e
constant: false
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:2348
initial concentration: NaN
name: FOLR1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110027#_0401a107_ccc5_4f6a_84be_801d73d5d490
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: PLA2G6
is encoded by: hsa:8398
is: O60733
boundary condition: true
constant: false
type: Species
initial concentration: NaN

metaM retinal 11 cis c
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:16066
is: SBO:0000247
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
name: 11-cis-retinal
constant: false
has only substance units: false
is: HMDB02152
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110027#_63388bd2_ac18_4503_ac2e_70c1952f17fa
constant: false
initial concentration: NaN
type: Species
is: Q96BD0
boundary condition: true
is encoded by: hsa:28231
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: SLCO4A1

metaR SEBACIDTD
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacic acid into cytosol (diffusion)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_582410e5_c4af_4c43_be1f_f122a383f24b
is encoded by: hsa:9123
is: SBO:0000252
name: SLC16A3
initial amount: NaN
initial concentration: NaN
is: O15427
constant: false
has only substance units: false
boundary condition: true
type: Species

metaM dolglcp L r
boundary condition: false
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
is: CHEBI:15812
has only substance units: false
initial amount: NaN
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1

metaM cgly e
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
is: CHEBI:4047
name: L-cysteinylglycine
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB00078
initial concentration: 1.0
constant: false

metaR RETH
name: retinyl ester hydrolase
fast: false
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (8228.1) SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:1503811,PMID:15955102 NOTES:IT
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.1.1.3
is described by: ECO:0000000
product: MODEL1310110027#
reactant: MODEL1310110027#
type: Reaction

metaM crn c
initial amount: NaN
has only substance units: false
is: HMDB00062
name: L-Carnitine
boundary condition: false
is: SBO:0000247
is: CHEBI:16347
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: C00318
constant: false
initial concentration: 1.0
type: Species

metaR NODe
is: SBO:0000185
kinetic law: MODEL1310110027#
product: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
type: Reaction
reactant: MODEL1310110027#
is described by: ECO:0000134
name: NODe

http://identifiers.org/biomodels.db/MODEL1310110027#_96a5e694_8a7a_4102_b58c_98e9e10f1bfd
initial amount: NaN
name: SLC26A6
constant: false
initial concentration: NaN
is encoded by: hsa:65010
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
is: Q9NQU1

metaR GLNCYSNaEx
modifier: MODEL1310110027#
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
type: Reaction
fast: false
product: MODEL1310110027#
name: L-cysteine/L-glutamine Na-dependent exchange (Gln-L in)
reactant: MODEL1310110027#

metaR FTCD
modifier: MODEL1310110027#
reversible: false
type: Reaction
name: formimidoyltransferase cyclodeaminase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.2.5
is described by: ECO:0000134
product: MODEL1310110027#
fast: false
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Folate metabolism EC Number: 4.3.1.4 Confidence Level: 4 AUTHORS: PMID:14697341 NOTES:IT
kinetic law: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_e398b536_cb7a_4d64_b143_70c88068c6b8
initial concentration: NaN
name: PPAT
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
is: Q06203
is encoded by: hsa:5471
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_852e04c4_a27b_49fe_b6d5_6fbad53a7383
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:34
initial concentration: NaN
is: SBO:0000252
name: ACADM
constant: false
is: P11310
has only substance units: false

metaR CYTK2
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP)
modifier: MODEL1310110027#
product: MODEL1310110027#
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
is described by: ECO:0000269
fast: false
reactant: MODEL1310110027#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110027#_7ad7aa8c_1151_436c_85ea_49496ba16ac3
initial amount: NaN
constant: false
is encoded by: hsa:7166
type: Species
name: TPH1
initial concentration: NaN
boundary condition: true
is: P17752
is: SBO:0000252
has only substance units: false

metaM nadph m
boundary condition: false
is: CHEBI:57783
is: HMDB00221
name: Nicotinamide adenine dinucleotide phosphate - reduced
type: Species
initial concentration: 1.0
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: C00005

metaR r1433
product: MODEL1310110027#
is: SBO:0000176
reactant: MODEL1310110027#
fast: false
type: Reaction
is described by: ECO:0000000
name: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9
reversible: false
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:

metaR DTDPtn
is described by: ECO:0000000
product: MODEL1310110027#
is: SBO:0000185
reactant: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110027#
fast: false
reversible: true
name: dTDP nuclear transport

metaM ksi pre30 g
is: CHEBI:58053
is: C00130
notes: FORMULA: C219H350N15O184S9X CHARGE: -10
constant: false
is: HMDB00175
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 30
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species

metaM nh4 e
type: Species
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:28938
is: HMDB00051
initial amount: NaN
constant: false
name: ammonium
boundary condition: false

metaR EX crn LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-Carnitine
type: Reaction

metaR RE3006M
is: SBO:0000176
reactant: MODEL1310110027#
type: Reaction
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
name: RE3006
kinetic law: MODEL1310110027#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110027#

metaM HC02216 e
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: prostaglandin-f2beta
is: CHEBI:28922
constant: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
boundary condition: false

metaM chol c
initial amount: NaN
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: C00114
is: CHEBI:15354
constant: false
name: Choline
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB00097
has only substance units: false

metaR MANt1r
name: mannose transport (uniport)
is described by: ECO:0000269
product: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (6513.1) or (6515.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:NCD
reversible: true
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
is: SBO:0000185
fast: false
reactant: MODEL1310110027#

metaM mi14p n
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
is: HMDB00968
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
constant: false
is: CHEBI:58282
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110027#_28cfd194_c09a_4d6c_9154_2e55dda16399
type: Species
has only substance units: false
is: P12074
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
name: COX6A1
is: SBO:0000252
is encoded by: hsa:1337

metaM 4hoxpacd c
is: HMDB03767
initial amount: NaN
name: (4-hydroxyphenyl)acetaldehyde
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:15621
has only substance units: false
type: Species
constant: false
notes: FORMULA: C8H8O2 CHARGE: 0 INCHI: InChI=1S/C8H8O2/c9-6-5-7-1-3-8(10)4-2-7/h1-4,6,10H,5H2 EHMN_ABBREVIATION: C03765

http://identifiers.org/biomodels.db/MODEL1310110027#_44214cd3_f4a4_4baa_9710_b1d1bad94c82
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is: P00568
is: SBO:0000252
boundary condition: true
is encoded by: hsa:203
constant: false
name: AK1

metaR TYRt
is described by: ECO:0000269
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110027#
reversible: true
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
name: L-tyrosine transport
product: MODEL1310110027#
modifier: MODEL1310110027#
reactant: MODEL1310110027#

metaM nmn c
is: SBO:0000247
is: HMDB00229
is: CHEBI:14649
constant: false
name: NMN
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
type: Species
is: C00455
boundary condition: false
has only substance units: false

metaR MALTSULtm
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
name: Malate:thiosulfate antiport, mitochondrial
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110027#
is: SBO:0000185
kinetic law: MODEL1310110027#
type: Reaction
product: MODEL1310110027#
reactant: MODEL1310110027#
fast: false

metaR DNDPt24m
is: SBO:0000185
product: MODEL1310110027#
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
is described by: ECO:0000269
fast: false
type: Reaction
name: dTDP transport via dADP antiport
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110027#

metaM guln c
has only substance units: false
constant: false
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
is: CHEBI:13115
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: L-gulonate
is: HMDB03290

http://identifiers.org/biomodels.db/MODEL1310110027#_70bb5f0f_db1a_4159_a1f1_3e814309db34
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000297
boundary condition: true
constant: false
type: Species
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
is encoded by: hsa:51227

http://identifiers.org/biomodels.db/MODEL1310110027#_996694ed_d5c0_40a1_a775_734232b6b9e5
initial concentration: NaN
has only substance units: false
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:8776
is: SBO:0000252
boundary condition: true
is: Q13613
name: MTMR1

http://identifiers.org/biomodels.db/MODEL1310110027#_5ebed0c0_c478_418c_8eec_dec13f3426c3
is: SBO:0000252
is encoded by: hsa:248
boundary condition: true
constant: false
name: ALPI
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is: P09923

metaR P5CRxm
is: SBO:0000176
fast: false
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (5831.1) or (5831.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: NOTES:PRO1x is irreversible in the other direction
is version of: http://identifiers.org/ec-code/1.5.1.2
product: MODEL1310110027#
reversible: false
kinetic law: MODEL1310110027#
is described by: ECO:0000304
reactant: MODEL1310110027#
name: pyrroline-5-carboxylate reductase (m)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_687756c0_ac2b_4612_9311_ee0ac3108313
boundary condition: true
is: SBO:0000252
is: Q9NRD9
initial concentration: NaN
initial amount: NaN
name: DUOX1
constant: false
type: Species
is encoded by: hsa:53905
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_cc3b1fba_ff84_4ab7_b79e_91e221dd8b84
has only substance units: false
has part: Q8NCI4
boundary condition: true
type: Species
is: SBO:0000297
name: PIGF:PIGG
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:54872

http://identifiers.org/biomodels.db/MODEL1310110027#_276fdc3f_7204_4566_adf5_94ce9bd18e28
boundary condition: true
type: Species
name: SKIV2L2
has only substance units: false
is encoded by: hsa:23517
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: Q3MHC9

metaR r0604
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
type: Reaction
reversible: false
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
is described by: ECO:0000000
product: MODEL1310110027#
name: (S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
modifier: MODEL1310110027#

metaM crn e
initial concentration: 1.0
has only substance units: false
is: CHEBI:16347
type: Species
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: SBO:0000247
name: L-Carnitine
constant: false
is: C00318
boundary condition: false
initial amount: NaN
is: HMDB00062

metaM acgam l
is: SBO:0000247
initial amount: NaN
name: N-acetyl-D-glucosamine
is: HMDB00215
type: Species
has only substance units: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
boundary condition: false
initial concentration: 1.0
is: CHEBI:17411
constant: false

metaR r2129
reversible: true
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110027#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110027#
type: Reaction
modifier: MODEL1310110027#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

metaR GLUDym
product: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
name: glutamate dehydrogenase (NADP), mitochondrial
is: SBO:0000176
reactant: MODEL1310110027#
modifier: MODEL1310110027#
reversible: true
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.4.1.3
kinetic law: MODEL1310110027#

metaR r0541
reversible: true
is: SBO:0000176
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
is described by: ECO:0000000
kinetic law: MODEL1310110027#
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.5
product: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
reactant: MODEL1310110027#
modifier: MODEL1310110027#

metaM g6p c
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
is: HMDB01401
is: CHEBI:61548
type: Species
has only substance units: false
constant: false
boundary condition: false
name: D-Glucose 6-phosphate
is: C00092
initial amount: NaN

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_b5911bf4_cacf_44ca_8bef_8f8317713d22
boundary condition: true
is: SBO:0000252
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:H17063
name: _H17063_1_m
initial amount: NaN

metaM lnlnca c
type: Species
name: alpha-linolenate
has only substance units: false
initial concentration: 1.0
is: CHEBI:32387
is: HMDB01388
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
is: SBO:0000247

metaR VALt4
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
type: Reaction
reactant: MODEL1310110027#
modifier: MODEL1310110027#
is described by: ECO:0000304
kinetic law: MODEL1310110027#
name: L-valine transport in via sodium symport
reversible: false
fast: false
is: SBO:0000185
product: MODEL1310110027#

metaR EX pheme LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for heme
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_c7a0533c_9a29_4235_a826_5d6c5200f9ab
name: UCP3
is encoded by: hsa:7352
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false

metaM itaccoa m
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
boundary condition: false
is: HMDB03377
constant: false
is: CHEBI:57381
type: Species
initial amount: NaN
initial concentration: 1.0
name: itaconyl-CoA(5-)
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_4de46607_7822_4dce_9cb3_277c47d391b4
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:7296
constant: false
initial concentration: NaN
has only substance units: false
name: TXNRD1

metaR GLNtN1
product: MODEL1310110027#
name: Glutamine transport (Na, H coupled)
fast: false
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
modifier: MODEL1310110027#
reversible: true
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
is: SBO:0000185

metaM aacoa m
has only substance units: false
name: acetoacetyl-CoA(4-)
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57286
is: SBO:0000247
boundary condition: false
type: Species
constant: false
is: HMDB01484
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332

metaR r0603
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
type: Reaction
reversible: true
is: SBO:0000176
product: MODEL1310110027#
is described by: ECO:0000000
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.3.1.12
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
fast: false
reactant: MODEL1310110027#

metaR r2128
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reversible: true
product: MODEL1310110027#
modifier: MODEL1310110027#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR OROTGLUt
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110027#
is described by: ECO:0000134
reactant: MODEL1310110027#
type: Reaction
name: OROTGLUt
fast: false
is: SBO:0000185
reversible: true

metaM dcsptn1coa c
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205483
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
is: C16173
is: HMDB06513
is: SBO:0000247
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_64f424bf_b15e_44c0_83cd_e20d37c2d3eb
is: P51178
is encoded by: hsa:5333
name: PLCD1
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false

metaM h c
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: H CHARGE: 1 INCHI: "
is: C00080
is: CHEBI:24636
type: Species
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3380
name: proton

http://identifiers.org/biomodels.db/MODEL1310110027#_2466391b_1127_49dd_9924_35d4c7d92ff9
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:4709
name: NDUFB3
is: Q6IB80

http://identifiers.org/biomodels.db/MODEL1310110027#_6c87fca5_3382_4a50_ae2f_3dc33fc26e6b
constant: false
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
name: _C7orf24_1_m
is encoded by: hsa:C7orf24
initial amount: NaN

metaM HC01104 e
initial amount: NaN
has only substance units: false
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
is: CHEBI:61146
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
name: 4-nitrophenyl phosphate(2-)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_4256b915_800d_441b_9bb9_e9ac1af427f1
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:7001
name: PRDX2
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN

metaR r0051
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
product: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
is version of: http://identifiers.org/ec-code/3.1.3.5
is described by: ECO:0000000
is: SBO:0000176
reversible: true
modifier: MODEL1310110027#
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
type: Reaction

metaR RE1898C
reversible: true
name: RE1898
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
is: SBO:0000176
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
is described by: ECO:0000000
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110027#_11f141a4_62db_4045_a461_7091d617f9cd
name: SLC5A8
constant: false
is: Q8N695
boundary condition: true
is encoded by: hsa:160728
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species

metaR RPEc
is: SBO:0000176
product: MODEL1310110027#
reversible: true
reactant: MODEL1310110027#
is described by: ECO:0000134
fast: false
name: ribulose 5-phosphate 3-epimerase
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
kinetic law: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_e36e07ce_69c7_4044_85d5_0904cfd082ab
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:51557
is: Q5TDP6
name: LGSN
constant: false

metaM HC02213 e
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:28031
initial concentration: 1.0
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
name: prostaglandin-e3
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_fe30baae_e3bc_4524_b195_c94015ef1da2
name: LDHAL6B
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: Q9BYZ2
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:92483
has only substance units: false

metaR H2Otn
is: SBO:0000185
reactant: MODEL1310110027#
fast: false
type: Reaction
name: H2O transport, nuclear
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110027#
is described by: ECO:0000000
product: MODEL1310110027#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110027#_3b8738ae_df03_44f3_a10b_2e1dabe08809
type: Species
boundary condition: true
name: CA6
is encoded by: hsa:765
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: Q5FC00

metaM pyr e
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
name: pyruvate
constant: false
boundary condition: false
has only substance units: false
is: HMDB00243
initial amount: NaN
is: CHEBI:15361
type: Species
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_c434ba9f_3461_4d58_91f6_6b63d2aa2c42
has only substance units: false
is: SBO:0000252
is: Q8NCG5
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:10164
constant: false
name: CHST4
type: Species

metaR S6T7g
reversible: false
modifier: MODEL1310110027#
reactant: MODEL1310110027#
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110027#
fast: false
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction

metaR PPCDC
reactant: MODEL1310110027#
product: MODEL1310110027#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110027#
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.36
name: phosphopantothenoylcysteine decarboxylase
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 4 AUTHORS: PMID:11923312 NOTES:
kinetic law: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_6bbf8f25_12a1_4ee3_aaa5_e48e5c21eeb5
constant: false
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4722
is: O75489
initial concentration: NaN
name: NDUFS3
boundary condition: true

metaM ksii core2 pre3 g
is: CHEBI:58053
has only substance units: false
notes: FORMULA: C47H76N4O33X CHARGE: -1
name: keratan sulfate II biosynthesis, precursor 3
is: HMDB00175
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: C00130
initial concentration: 1.0
constant: false

metaM 1p3h5c m
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:6151
type: Species
is: HMDB01369
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281

metaM lac D c
is: CHEBI:16004
is: HMDB01311
name: (R)-lactate
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
has only substance units: false
type: Species
initial amount: NaN

metaR 3MOBte
reactant: MODEL1310110027#
type: Reaction
reversible: true
product: MODEL1310110027#
fast: false
name: Transport of 3-methyl-2-oxobutanoate
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000185

metaR PAIL4P HStn
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
type: Reaction
fast: false
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)
is: SBO:0000185
is described by: ECO:0000000
reversible: true

metaM pyr c
is: C00022
is: SBO:0000247
notes: FORMULA: C3H3O3 CHARGE: -1
has only substance units: false
is: HMDB00243
name: pyruvate
is: CHEBI:15361
is: http://identifiers.org/pubchem.compound/3324
constant: false
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0

metaM lnlnca e
boundary condition: false
is: HMDB01388
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
type: Species
constant: false
is: CHEBI:32387
name: alpha-linolenate
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_420e8467_eb58_4b12_85d3_bb5040569382
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:8818
has only substance units: false
type: Species
constant: false
boundary condition: true
name: DPM2

http://identifiers.org/biomodels.db/MODEL1310110027#_metaR_EX_s2l2fn2m2masn_LPAREN_e_RPAREN_
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: PA6 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_8007b23f_b509_4c74_9d5c_e752ed663fa2
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
name: GGT7
is encoded by: hsa:2686
is: A0PJJ9
has only substance units: false

metaR DESAT20 1
is: SBO:0000176
product: MODEL1310110027#
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
name: fatty acyl-CoA desaturase (n-C20:3CoA -> n-C20:4CoA)
is described by: ECO:0000000
modifier: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_ee78e2f1_ae9b_4c59_a66a_4c53b20d4696
initial concentration: NaN
has only substance units: false
boundary condition: true
is: B7Z6M3
type: Species
is: SBO:0000252
constant: false
name: DGKZ
initial amount: NaN
is encoded by: hsa:8525

metaR H2Otm
reversible: true
modifier: MODEL1310110027#
is described by: ECO:0000269
reactant: MODEL1310110027#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
name: H2O transport, mitochondrial
kinetic law: MODEL1310110027#
fast: false
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_c3b2eacb_1c4d_4b8c_92f7_d561fb61d216
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
type: Species
is encoded by: hsa:622
name: BDH1

http://identifiers.org/biomodels.db/MODEL1310110027#_f781c552_3a4e_410a_8ba2_7f892181ecb9
constant: false
boundary condition: true
is: Q16739
type: Species
is encoded by: hsa:7357
is: SBO:0000252
has only substance units: false
name: UGCG
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_be65aa5a_242e_4e69_a4c0_2d179f71463f
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5092
has only substance units: false
name: PCBD1
is: SBO:0000252
boundary condition: true

metaM thr L c
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:16857
has only substance units: false
type: Species
is: HMDB00167
name: L-threonine

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_e865bb23_1c64_406c_b2c7_e4aff273c6b2
has only substance units: false
name: ALDH3A1
boundary condition: true
is encoded by: hsa:218
is: P30838
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN

metaM HC02213 c
name: prostaglandin-e3
type: Species
initial concentration: 1.0
is: CHEBI:28031
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false

metaR r0392
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
reactant: MODEL1310110027#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110027#
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
fast: false
product: MODEL1310110027#

metaM lnlc e
is: SBO:0000247
name: linoleate
is: CHEBI:30245
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
boundary condition: false
is: HMDB00673

http://identifiers.org/biomodels.db/MODEL1310110027#_6f23a5c6_cca2_4bb8_9423_66f5523759de
is encoded by: hsa:6392
is: SBO:0000252
type: Species
name: SDHD
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
is: O14521
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_fdf7b110_3923_46fb_a33f_d54f396af17c
is encoded by: hsa:84532
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: ACSS1
has only substance units: false
boundary condition: true
is: Q9NUB1
constant: false
type: Species

metaR r2390
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110027#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110027#
product: MODEL1310110027#
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110027#_4ff88f21_221b_423c_bd68_8540ad21033a
is: Q13123
is encoded by: hsa:3550
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
name: IK

metaR r0311
is version of: http://identifiers.org/ec-code/2.3.1.9
kinetic law: MODEL1310110027#
is described by: ECO:0000000
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
type: Reaction
product: MODEL1310110027#
modifier: MODEL1310110027#
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
fast: false
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110027#_56338b97_63b7_4b2e_aea0_385b3c391ad5
is: SBO:0000252
boundary condition: true
is encoded by: hsa:375056
initial concentration: NaN
is: Q5JRA6
type: Species
constant: false
initial amount: NaN
name: MIA3
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_c9d8ee1b_f90a_47da_a56d_006c7774b8d8
boundary condition: true
type: Species
constant: false
is: SBO:0000252
name: SLC6A10P
initial amount: NaN
has only substance units: false
is encoded by: hsa:386757
initial concentration: NaN

metaR r0464
is: SBO:0000176
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
fast: false
type: Reaction
product: MODEL1310110027#
is described by: ECO:0000000
kinetic law: MODEL1310110027#
reversible: true

metaR LDH L
name: L-lactate dehydrogenase
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
reactant: MODEL1310110027#
type: Reaction
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.27
fast: false

metaR FACOAL1832
is described by: ECO:0000269
reactant: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ, RE3114C
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
is: SBO:0000176
reversible: true
product: MODEL1310110027#

metaR DMNONCRNt
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
reactant: MODEL1310110027#
is described by: ECO:0000000
product: MODEL1310110027#
type: Reaction
name: 4,8 dimethylnonanoyl carnitine transport (mitochondria)
kinetic law: MODEL1310110027#
is: SBO:0000185

metaR THRSERNaEx
modifier: MODEL1310110027#
reactant: MODEL1310110027#
fast: false
kinetic law: MODEL1310110027#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-serine/L-threonine Na-dependent exchange (Thr-L in)
type: Reaction
product: MODEL1310110027#
is described by: ECO:0000269
reversible: false

metaR EX sarcs LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sarcosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_d666a494_0f9f_447c_ac82_ebff644cfbae
boundary condition: true
is: P43353
constant: false
is: SBO:0000252
is encoded by: hsa:221
initial concentration: NaN
name: ALDH3B1
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_3af7a59e_0e1b_4f43_8ee1_d52e0ecd0e40
name: AMY2A
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
is: P04746
type: Species
is: SBO:0000252
is encoded by: hsa:279
initial amount: NaN

metaM but c
has only substance units: false
initial amount: NaN
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
type: Species
boundary condition: false
is: SBO:0000247
name: butyrate
initial concentration: 1.0
is: HMDB00039
constant: false
is: CHEBI:17968

http://identifiers.org/biomodels.db/MODEL1310110027#_fea1bbdf_41b6_4fa6_aaff_f3e2749defdc
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110027#_6b07a56a_1b0e_4d2a_bcaa_57c48a8b07d8
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: Q6LEN6
has only substance units: false
is encoded by: hsa:1103
constant: false
name: CHAT
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110027#_acd56287_145c_407e_a8be_d6d1338892f4
is: O95045
type: Species
boundary condition: true
constant: false
is encoded by: hsa:151531
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: UPP2

metaR r2054
kinetic law: MODEL1310110027#
fast: false
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110027#
type: Reaction
reactant: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_1c4be8f1_85fc_4265_b04f_154940eaae99
type: Species
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is: O60760
is encoded by: hsa:27306
has only substance units: false
name: HPGDS

metaR r0393
kinetic law: MODEL1310110027#
fast: false
is: SBO:0000176
reversible: false
modifier: MODEL1310110027#
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
is version of: http://identifiers.org/ec-code/2.7.1.74
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
product: MODEL1310110027#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110027#

metaR NDPK10
type: Reaction
product: MODEL1310110027#
fast: false
kinetic law: MODEL1310110027#
name: nucleoside-diphosphate kinase (ATP:dIDP)
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
modifier: MODEL1310110027#
is described by: ECO:0000134
reactant: MODEL1310110027#
reversible: true
is: SBO:0000176

metaM glcur c
initial amount: NaN
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB00127
is: CHEBI:15748
type: Species
name: D-glucuronate
is: SBO:0000247
constant: false

metaR H2Otg
fast: false
type: Reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110027#
product: MODEL1310110027#
name: H2O transport, Golgi apparatus
reactant: MODEL1310110027#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110027#_aa6f8da2_2310_4d9e_9f85_7adb03aa317f
name: ALG3
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:10195
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252

metaR CLOXAtex2
is described by: ECO:0000304
fast: false
reversible: false
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
name: chloride transport via oxalate countertransport (2:1)
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB

metaR r0463
is: SBO:0000176
reactant: MODEL1310110027#
name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10
product: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:
is described by: ECO:0000000
fast: false

metaR FTHFL
product: MODEL1310110027#
name: Formate-tetrahydrofolate ligase
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.5.1.5
fast: false
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (4522.1) or (286297.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110027#
type: Reaction
reactant: MODEL1310110027#
is described by: ECO:0000134

metaM nadph c
has only substance units: false
is: C00005
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: HMDB00221
name: Nicotinamide adenine dinucleotide phosphate - reduced
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57783

metaR NDPK8n
reversible: true
type: Reaction
product: MODEL1310110027#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear
is: SBO:0000176
fast: false
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus

http://identifiers.org/biomodels.db/MODEL1310110027#_9d76b4fa_66d5_42fc_b452_024f114c6357
boundary condition: true
is: Q9UI40
type: Species
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
name: SLC24A2
is encoded by: hsa:25769
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110027#_1a1559ec_0a97_4217_865e_3462a64af9bf
initial amount: NaN
type: Species
is encoded by: hsa:5138
is: Q8IW54
initial concentration: NaN
name: PDE2A
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true

metaM hxcoa x
has only substance units: false
is: HMDB00705
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: Hexanoyl-CoA (n-C6:0CoA)
type: Species
boundary condition: false
constant: false
notes: FORMULA: C27H42N7O17P3S CHARGE: -4

metaR C226COAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reversible: true
type: Reaction
is: SBO:0000185
reactant: MODEL1310110027#
name: fatty acid intracellular transport
product: MODEL1310110027#
is described by: ECO:0000000
kinetic law: MODEL1310110027#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110027#_994f1f2b_79aa_4efc_84b5_e5cfdae1b8cc
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:84720
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
name: PIGO

http://identifiers.org/biomodels.db/MODEL1310110027#_3a2e40df_77cb_4118_98cd_47d20ddc2d8b
name: MTHFD1
initial amount: NaN
is: P11586
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:4522
initial concentration: NaN
type: Species

metaR DURAD2
is described by: ECO:0000269
name: dihydrothymin dehydrogenase (NADP)
fast: false
reactant: MODEL1310110027#
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.3.1.2
reversible: true
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
is: SBO:0000176
product: MODEL1310110027#
type: Reaction

metaR EX c6crn
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hexanoyl carnitine
type: Reaction

metaR r2051
type: Reaction
reversible: false
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is: SBO:0000185
fast: false
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaR r0390
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110027#_da803b1a_b917_4119_9b66_49f0324857d7
initial concentration: NaN
has only substance units: false
is encoded by: hsa:51227
name: PIGP
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
constant: false

metaM lnlc c
is: HMDB00673
name: linoleate
type: Species
boundary condition: false
constant: false
is: CHEBI:30245
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_6f7c22b2_b21e_43b7_8dec_3c608a50e6ea
name: _R39999_1_c
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:R39999
constant: false
initial amount: NaN
type: Species

metaR PIACGT
modifier: MODEL1310110027#
fast: false
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110027#
name: phosphatidylinositol N-acetylglucosaminyltransferase
notes: GENE_ASSOCIATION: (5279.1) and (51227.2) and (5283.1) and (5277.2) and (9091.1) and (8818.1) or (5279.1) and (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) or (51227.1) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.2) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (5279.2) and (8818.1) or (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.1) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.2) or (51227.1) and (5277.1) and (5283.1) and (9091.1) and (5279.2) and (8818.1) or (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (9091.2) and (5277.3) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (8818.2) and (5279.2) or (5279.1) and (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.2) or (51227.1) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.2) and (9091.2) and (5277.1) and (5283.1) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.2) and (5283.1) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (5283.1) and (5277.2) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (5283.1) and (5277.2) and (9091.1) and (8818.2) or (51227.3) and (9091.2) and (5283.1) and (5277.2) and (5279.2) and (8818.1) or (5279.1) and (51227.3) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (51227.1) and (9091.2) and (5277…
kinetic law: MODEL1310110027#
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.4.1.83
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.198

http://identifiers.org/biomodels.db/MODEL1310110027#_a9015c29_56b0_4c06_abfa_122cf251de9d
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: HIBADH
type: Species
is: P31937
has only substance units: false
is encoded by: hsa:11112
initial concentration: NaN

metaR DGSNtm
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:3696164 NOTES:
reactant: MODEL1310110027#
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110027#
name: deoyguanosine transport in mitochondria
is described by: ECO:0000000
kinetic law: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_687ce978_bfef_4f07_97fa_441da10039e5
type: Species
is: SBO:0000252
is: Q9NQ66
initial concentration: NaN
name: PLCB1
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:23236
has only substance units: false

metaR NICRNS
reactant: MODEL1310110027#
name: NICRNS
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:no gene or enzyme name known (in kegg) but reaction has to take place. IT
kinetic law: MODEL1310110027#
is described by: ECO:0000000
product: MODEL1310110027#
fast: false
type: Reaction
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110027#_6d0a40b4_0774_4cfb_9b91_ce86fcaac48f
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q9BZQ4
is: SBO:0000252
initial concentration: NaN
name: NMNAT2
is encoded by: hsa:23057
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_42d8b40b_2493_4ea8_87ce_d2837f26fda2
boundary condition: true
type: Species
is encoded by: hsa:27034
is: Q6ZWP6
constant: false
is: SBO:0000252
name: ACAD8
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR r2392
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
reactant: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110027#_1ec6872f_6cf4_4401_b660_41448310eae1
initial concentration: NaN
is encoded by: hsa:23556
type: Species
has only substance units: false
name: PIGN
is: O95427
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR O2tp
is described by: ECO:0000000
reactant: MODEL1310110027#
fast: false
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
kinetic law: MODEL1310110027#
reversible: true
is: SBO:0000185
name: O2 transport, peroxisomal

metaR PPD2CSPp
type: Reaction
is described by: ECO:0000000
name: PPD2CSPp
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:spontaneous cyclization reaction MM
is: SBO:0000176
reversible: false
fast: false

metaM CE2435 m
name: trans,cis-deca-2,4-dienoyl-CoA
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:57795
initial concentration: 1.0

metaM CE1944 c
has only substance units: false
notes: FORMULA: C4H8N CHARGE: 1 INCHI: InChI=1S/C4H7N/c1-2-4-5-3-1/h3H,1-2,4H2/p+1 EHMN_ABBREVIATION: CE1944
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
name: 1-pyrrolinium
constant: false
boundary condition: false
is: CHEBI:36781

http://identifiers.org/biomodels.db/MODEL1310110027#_d3bf24c1_b7a5_44b4_812b_30c7ee2b9d40
is encoded by: hsa:9420
initial amount: NaN
boundary condition: true
is: O75881
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
name: CYP7B1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_f496a884_21fa_4af2_990c_4694cfd3a2db
type: Species
is encoded by: hsa:53354
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: PANK1
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_823bea5a_3e1e_45c7_a0e2_d1afa169313b
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaM but e
name: butyrate
constant: false
is: CHEBI:17968
is: SBO:0000247
is: HMDB00039
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
initial amount: NaN
boundary condition: false

metaM 2octpencoa m
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
initial amount: NaN
has only substance units: false
constant: false
is: HMDB02288
name: 2,6,9,12,15-octadecapentenoylcoa
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR NMNATr
is: SBO:0000176
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110027#
is described by: ECO:0000269
name: nicotinamide-nucleotide adenylyltransferase
kinetic law: MODEL1310110027#
product: MODEL1310110027#
fast: false
reversible: true
modifier: MODEL1310110027#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.1

metaM HC00342 c
constant: false
name: cis-aconitate(3-)
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:16383
type: Species
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
has only substance units: false
initial concentration: 1.0

metaM CE5120 m
is: CHEBI:57923
initial amount: NaN
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,14-15,22-24,28-30,34,45-46H,4-7,10-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5120
boundary condition: false
name: trans-2-cis-8-tetradecadienoyl-CoA
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species

metaM HC01406 m
is: CHEBI:28264
name: 3-Oxooctanoyl-CoA
is: SBO:0000247
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267
boundary condition: false
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
has only substance units: false

metaR r2052
reactant: MODEL1310110027#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
fast: false
modifier: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_14fc1645_4d57_4212_a717_2c79ec30f4ca
name: NDUFS7
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:374291
is: O75251
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false

metaR r0899
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
product: MODEL1310110027#
name: Amino acid transporter ATB0+ Facilitated diffusion
fast: false
is: SBO:0000185

metaR RE1807C
fast: false
product: MODEL1310110027#
name: RE1807
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reversible: true
reactant: MODEL1310110027#

metaR r0391
is described by: ECO:0000000
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is: SBO:0000176
name: Nicotinate D-ribonucleotide:pyrophosphate phosphoribosyltransferase Nicotinate and nicotinamide metabolism EC:2.4.2.11
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 2.4.2.11 Confidence Level: 0 AUTHORS: PMID:17604275 NOTES:
fast: false
type: Reaction

metaM glcur e
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
boundary condition: false
initial concentration: 1.0
is: HMDB00127
is: SBO:0000247
is: CHEBI:15748
type: Species
constant: false
has only substance units: false
name: D-glucuronate
initial amount: NaN

metaR RE1519M
fast: false
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
kinetic law: MODEL1310110027#
reversible: true
name: RE1519
product: MODEL1310110027#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110027#
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.3.99.13
is version of: http://identifiers.org/ec-code/1.3.3.6

metaR RE2269E
fast: false
modifier: MODEL1310110027#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.21.39
reversible: true
kinetic law: MODEL1310110027#
product: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
name: RE2269
is: SBO:0000176
reactant: MODEL1310110027#

metaM c226coa m
has only substance units: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
constant: false
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205479
is: C16169
type: Species
name: cervonyl coenzyme A
is: SBO:0000247
initial concentration: 1.0

metaM ksi pre1 g
is: CHEBI:58053
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 1
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C79H129N5O57X CHARGE: -1
type: Species
initial amount: NaN
is: C00130
initial concentration: 1.0
boundary condition: false

metaM glyc R c
constant: false
has only substance units: false
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
boundary condition: false
name: D-glycerate
type: Species
initial concentration: 1.0
is: HMDB00139
is: SBO:0000247
is: CHEBI:16659
initial amount: NaN

metaM dcsptn1coa m
type: Species
boundary condition: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
is: C16173
is: HMDB06513
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205483

metaR r2393
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
reactant: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reversible: true
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110027#_9e261cd9_7a0c_4420_867a_9c7c4b3bcdd5
has only substance units: false
type: Species
constant: false
name: NDUFB11
boundary condition: true
initial amount: NaN
is: Q9NX14
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:54539

http://identifiers.org/biomodels.db/MODEL1310110027#_b63d59b8_a2f4_4fe3_95a2_ed3301284134
is: O15254
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:8310
name: ACOX3
constant: false
boundary condition: true

metaR CTPS2
is described by: ECO:0000269
name: CTP synthase (glutamine)
is version of: http://identifiers.org/ec-code/6.3.4.2
modifier: MODEL1310110027#
reversible: false
fast: false
kinetic law: MODEL1310110027#
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (56474.1) or (56474.2) SUBSYSTEM: Pyrimidine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
type: Reaction
reactant: MODEL1310110027#

metaR PMTCOAtx
kinetic law: MODEL1310110027#
name: fatty acid intracellular transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reactant: MODEL1310110027#
product: MODEL1310110027#
is: SBO:0000185
type: Reaction
reversible: true
fast: false

metaR PROSTGD2t
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
product: MODEL1310110027#
fast: false
type: Reaction
name: prostaglandin transport via bicarbonate countertransport
modifier: MODEL1310110027#
is: SBO:0000185
is described by: ECO:0000269
reversible: true

metaR LEUKTRA4t
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
name: leukotriene A4 transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:
type: Reaction
fast: false
reversible: true
product: MODEL1310110027#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110027#_20e54a0a_300a_473b_b181_02e8cd4247cc
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: O00219
initial concentration: NaN
is encoded by: hsa:3038
name: HAS3

metaM glu L l
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB00148
initial amount: NaN
is: CHEBI:29985
constant: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
name: L-glutamate(1-)
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_edb90d51_6cf7_41ea_bb16_4692e66b70a4
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:30061
name: SLC40A1
type: Species
initial amount: NaN
is: Q9NP59
boundary condition: true
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_2deea5a9_e96d_4780_b7db_fe5a6636715a
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:3073
constant: false
has only substance units: false
is: P06865
boundary condition: true
name: HEXA
type: Species
initial concentration: NaN

metaR ECOAH9m
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110027#
reactant: MODEL1310110027#
modifier: MODEL1310110027#
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
is described by: ECO:0000304
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
type: Reaction
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110027#_32bf1dc3_835a_4747_b132_24f7f6426269
type: Species
is: SBO:0000252
name: SLC23A2
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:9962

http://identifiers.org/biomodels.db/MODEL1310110027#_d2b647fa_f5dd_4764_86ab_0a51901fa9ae
initial concentration: NaN
has only substance units: false
is: P54819
boundary condition: true
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:204
initial amount: NaN
name: AK2

metaM HC00591 m
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
name: 2-oxoglutaramate
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
is: CHEBI:16769

metaR EX prostgf2 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin F2alpha exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_bcd4b1f8_cb33_4c0b_b0d2_fc3a22edb060
type: Species
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
name: NDUFS5
is: Q6IBA0
initial concentration: NaN
is encoded by: hsa:4725
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110027#_18894ceb_758f_4a65_9691_45a6dbb57eaa
is: P10696
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
name: ALPPL2
is encoded by: hsa:251

http://identifiers.org/biomodels.db/MODEL1310110027#_225030b7_5870_41e7_82ac_89b929e0eeb3
name: PIP4K2B
boundary condition: true
type: Species
is: P78356
initial concentration: NaN
is encoded by: hsa:8396
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252

metaR r0960
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
product: MODEL1310110027#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
type: Reaction
reversible: true
kinetic law: MODEL1310110027#
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110027#_ca2ada04_d9e1_40ce_8b38_beb92cf3123b
type: Species
is: P36269
name: GGT5
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:2687

http://identifiers.org/biomodels.db/MODEL1310110027#_5c94c835_0341_405f_b694_91e94b15392c
boundary condition: true
initial amount: NaN
name: SLC25A26
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:115286

http://identifiers.org/biomodels.db/MODEL1310110027#_6bc0e53b_76c4_43e6_bf85_961b51f89703
is encoded by: hsa:79087
type: Species
constant: false
is: Q9BV10
has only substance units: false
initial amount: NaN
name: ALG12
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaM pail4p hs c
is: CHEBI:58178
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
initial amount: NaN
has only substance units: false
constant: false
type: Species
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_715d0c58_3361_40c0_a0e2_f09ea40632de
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
is: P30837
has only substance units: false
is encoded by: hsa:219
name: ALDH1B1

metaR r1649
type: Reaction
is: SBO:0000185
product: MODEL1310110027#
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110027#
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaM 1pipdn2c x
initial concentration: 1.0
name: 1-piperideine-2-carboxylate
type: Species
is: CHEBI:16187
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092
is: HMDB01084

http://identifiers.org/biomodels.db/MODEL1310110027#_49d54fab_ddfc_416a_970d_d3df4bbd0573
is encoded by: hsa:80704
constant: false
has only substance units: false
initial concentration: NaN
name: SLC19A3
boundary condition: true
is: SBO:0000252
is: Q9BZV2
type: Species
initial amount: NaN

metaR DRPA
fast: false
is: SBO:0000176
kinetic law: MODEL1310110027#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
name: deoxyribose-phosphate aldolase
reactant: MODEL1310110027#
product: MODEL1310110027#

metaR RE3346M
name: RE3346
reversible: true
is: SBO:0000176
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110027#
type: Reaction
fast: false
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (217.1) or (219.1) or (501.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
product: MODEL1310110027#
is described by: ECO:0000000

metaM leugly c
is: http://identifiers.org/pubchem.compound/97364
name: Leucylglycine
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C8H16N2O3 CHARGE: 0

metaR r1435
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
product: MODEL1310110027#
type: Reaction
is described by: ECO:0000000
reversible: false
is: SBO:0000185
name: Transport reaction
fast: false

metaR GLYSNAT5tc
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_2c7a5ba4_02e6_42d1_a49d_dfb1728f576f
is: SBO:0000252
name: DGKD
boundary condition: true
has only substance units: false
is: Q16760
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:8527

http://identifiers.org/biomodels.db/MODEL1310110027#_60c372cd_4493_4a0c_8ba4_a45944e9a67f
boundary condition: true
is: SBO:0000252
has only substance units: false
name: NDUFB9
type: Species
initial concentration: NaN
constant: false
is: Q9Y6M9
initial amount: NaN
is encoded by: hsa:4715

metaM dmnoncrn x
constant: false
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
name: 4,8-dimethylnonanoyl carnitine
boundary condition: false
is: HMDB06202
initial concentration: 1.0
notes: FORMULA: C18H37NO4 CHARGE: 0

metaR Ser Thrtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
reversible: true
is described by: ECO:0000269
name: Ser/Thr transport (from golgi to lysosome)
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110027#
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#

metaM ura c
is: C00106
is: HMDB00300
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:17568
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
name: Uracil

http://identifiers.org/biomodels.db/MODEL1310110027#_1a30c560_f7a1_4dc6_87e6_9da9e68e9ed6
is: Q6ZMR3
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:160287
type: Species
has only substance units: false
name: LDHAL6A

metaM arachdcoa c
has only substance units: false
name: arachidonoyl-CoA(4-)
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
is: CHEBI:57368
type: Species
is: HMDB06523
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110027#_be49d5e5_1f48_4da5_8a82_999dda9f33af
constant: false
initial concentration: NaN
boundary condition: true
name: GBA
is encoded by: hsa:2629
initial amount: NaN
is: B7Z5G2
type: Species
has only substance units: false
is: SBO:0000252

metaM c8dc x
constant: false
initial concentration: 1.0
initial amount: NaN
name: suberyl carnitine
is: C08277
notes: FORMULA: C15H26NO6 CHARGE: -1
boundary condition: false
is: SBO:0000247
is: HMDB00792
type: Species
has only substance units: false

metaM thr L e
name: L-threonine
constant: false
is: CHEBI:16857
is: SBO:0000247
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB00167
has only substance units: false
initial amount: NaN

metaR r0317
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.1.2.10
fast: false
is: SBO:0000176
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.8.1.4
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
type: Reaction
kinetic law: MODEL1310110027#
reversible: true
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.4.4.2
reactant: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_013c7fb1_4790_431f_beaa_af01cb932b75
is encoded by: hsa:115019
constant: false
boundary condition: true
name: SLC26A9
is: B3KXK1
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_b9d40029_ed85_4df9_a79a_a41d536e738b
has only substance units: false
constant: false
name: ENTPD8
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: Q5MY95
is encoded by: hsa:377841

metaR UGALGTg
product: MODEL1310110027#
kinetic law: MODEL1310110027#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (3906.1) and (2683.1) or (8704.2) or (8704.1) SUBSYSTEM: Galactose metabolism EC Number: 2.4.1.22 Confidence Level: 4 AUTHORS: PMID:11419947 NOTES:NCD
name: UDPgalactose:D-glucose 4-beta-D-galactosyltransferase, Golgi apparatus
fast: false
is: SBO:0000176
reversible: false
modifier: MODEL1310110027#
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction

metaR NDP8
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110027#
modifier: MODEL1310110027#
is described by: ECO:0000269
product: MODEL1310110027#
kinetic law: MODEL1310110027#
name: nucleoside-diphosphatase (dUDP)
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.9
fast: false
reversible: false
is: SBO:0000176

metaR r1841
name: Y+LAT2 Utilized transport
type: Reaction
is: SBO:0000185
product: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
reversible: false
modifier: MODEL1310110027#

metaR EX dopa LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine exchange
type: Reaction

metaR CYTK10n
reactant: MODEL1310110027#
fast: false
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110027#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP,dGTP),nuclear
is described by: ECO:0000269
modifier: MODEL1310110027#
type: Reaction

metaR r0962
kinetic law: MODEL1310110027#
name: Facilitated diffusion
reversible: false
type: Reaction
is: SBO:0000185
product: MODEL1310110027#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
reactant: MODEL1310110027#

metaR r0394
type: Reaction
is described by: ECO:0000000
product: MODEL1310110027#
reactant: MODEL1310110027#
reversible: true
kinetic law: MODEL1310110027#
is: SBO:0000176
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
fast: false

metaR GLYPHEHYc
reversible: true
kinetic law: MODEL1310110027#
is described by: ECO:0000134
fast: false
product: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 1 AUTHORS: most probable reaction. added during gap filling. NOTES:most probable reaction. added during gap filling.
is: SBO:0000176
name: hydrolysis of glycylphenylalanine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_aaf0b3f4_d90e_4841_9a98_067f1758a4b1
boundary condition: true
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
is: Q9NY28
name: GALNT8
initial concentration: NaN
is encoded by: hsa:26290

metaR 4NPHSFte
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9344226 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Biochemical, Rat
fast: false
type: Reaction
reactant: MODEL1310110027#
product: MODEL1310110027#
name: xenobiotic transport
is: SBO:0000185
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110027#_5aef416c_cc82_46da_a711_bd9f3cb4374f
boundary condition: true
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
name: NDUFS3
initial concentration: NaN
has only substance units: false
is: O75489
is encoded by: hsa:4722

metaM chtn e
initial concentration: 1.0
is: HMDB03362
name: chitin
has only substance units: false
is: CHEBI:17029
boundary condition: false
constant: false
notes: FORMULA: C24H41N3O16 CHARGE: 0 INCHI: InChI=1S/C24H41N3O16/c1-7(31)25-13-18(36)20(11(5-29)39-22(13)38)42-24-15(27-9(3)33)19(37)21(12(6-30)41-24)43-23-14(26-8(2)32)17(35)16(34)10(4-28)40-23/h10-24,28-30,34-38H,4-6H2,1-3H3,(H,25,31)(H,26,32)(H,27,33)/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+,24+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02118
type: Species
initial amount: NaN
is: SBO:0000247

metaR S6T14g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is described by: ECO:0000000
reversible: false
is: SBO:0000176
product: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
fast: false
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

metaM aacoa c
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01484
initial amount: NaN
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
type: Species
has only substance units: false
name: Acetoacetyl-CoA
is: C00332
is: CHEBI:57286
boundary condition: false

metaM glu L m
constant: false
initial concentration: 1.0
is: HMDB00148
is: SBO:0000247
initial amount: NaN
is: CHEBI:29985
boundary condition: false
name: L-glutamate(1-)
type: Species
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
has only substance units: false

metaR r1842
type: Reaction
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
is: SBO:0000185
fast: false
reversible: false
modifier: MODEL1310110027#
name: Y+LAT2 Utilized transport

metaM leugly e
notes: FORMULA: C8H16N2O3 CHARGE: 0
boundary condition: false
name: Leucylglycine
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/97364

metaR r2397
is described by: ECO:0000000
reactant: MODEL1310110027#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110027#
kinetic law: MODEL1310110027#
reversible: false
fast: false

metaR FE3R2e
name: Fe(III) reduction (ascorbate)
is described by: ECO:0000269
kinetic law: MODEL1310110027#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (79901.1) SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11230685,PMID:12755454 NOTES:stoichiometry unknown; inferred from EC1.16.1.7 NCD
product: MODEL1310110027#
type: Reaction
reactant: MODEL1310110027#
modifier: MODEL1310110027#
reversible: false

metaR O2tm
fast: false
product: MODEL1310110027#
is described by: ECO:0000000
reactant: MODEL1310110027#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110027#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
name: O2 transport (diffusion)

http://identifiers.org/biomodels.db/MODEL1310110027#_4f436945_948f_4cfb_b910_e53c264a9e7d
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110027#_d20f0fd1_9d2c_4da8_bae8_f332594abce2
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
name: _AI222095_1_e
is encoded by: hsa:AI222095
is: SBO:0000252
initial concentration: NaN
type: Species

metaM CE2432 m
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
is: CHEBI:57795
has only substance units: false
is: SBO:0000247
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
boundary condition: false

metaM k e
constant: false
boundary condition: false
initial concentration: 1.0
name: potassium
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
is: CHEBI:29103
initial amount: NaN
is: SBO:0000247
is: C00238
type: Species
is: HMDB00586
has only substance units: false

metaR r0963
reactant: MODEL1310110027#
product: MODEL1310110027#
name: Facilitated diffusion
reversible: false
kinetic law: MODEL1310110027#
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
is described by: ECO:0000000

metaR r0395
reversible: true
fast: false
kinetic law: MODEL1310110027#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:11993848,PMID:1643670,PMID:3010873,PMID:8343533 NOTES:
type: Reaction
is described by: ECO:0000000
product: MODEL1310110027#
reactant: MODEL1310110027#
name: Hypoxanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2

metaR CYTK2n
kinetic law: MODEL1310110027#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110027#
reversible: true
name: cytidylate kinase (dCMP),nuclear
reactant: MODEL1310110027#
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_36de8120_a1bf_4e75_9729_d475f541ebb0
name: PYCRL
initial amount: NaN
is encoded by: hsa:65263
type: Species
boundary condition: true
is: Q53H96
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252

metaR R group phosphotase 3
reactant: MODEL1310110027#
name: R group phosphotase 3
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110027#
reversible: false
is: SBO:0000176
product: MODEL1310110027#

metaM HC00900 c
has only substance units: false
name: Methylmalonate
is: CHEBI:30860
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170

http://identifiers.org/biomodels.db/MODEL1310110027#_414ec2a0_3923_4350_a484_0bd6a4de40b5
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_a0504489_b647_4bc1_a783_c03decadfece
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: NDUFA4L2
type: Species
constant: false
boundary condition: true
is: Q9NRX3
initial amount: NaN
is encoded by: hsa:56901

metaM pail5p hs n
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:57795
has only substance units: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)

http://identifiers.org/biomodels.db/MODEL1310110027#_ecf1de6f_4a4f_451a_8e2a_6e75ce453732
initial concentration: NaN
initial amount: NaN
name: LDHAL6B
is encoded by: hsa:92483
constant: false
type: Species
is: SBO:0000252
is: Q9BYZ2
boundary condition: true
has only substance units: false

metaM gdp g
boundary condition: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB01201
is: CHEBI:58189
name: GDP(3-)
initial concentration: 1.0
type: Species

metaR r1647
modifier: MODEL1310110027#
product: MODEL1310110027#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_87cb4b68_1857_4e1a_96dd_e1ff6800a479
initial amount: NaN
name: ACAD9
is: SBO:0000252
is encoded by: hsa:28976
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is: Q9H845
type: Species

metaR DM Lcystin
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for L-cystine
type: Reaction

metaM ksii core2 deg2 l
is: SBO:0000247
is: HMDB00143
notes: FORMULA: C70H114N5O56S2X CHARGE: -2
initial amount: NaN
boundary condition: false
type: Species
name: keratan sulfate II (core 2-linked), degradation product 2
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:12936

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaR G14T14g
reactant: MODEL1310110027#
modifier: MODEL1310110027#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD

metaR EX bglc LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange reaction for beta glucans
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_5d0dd06a_a662_4a7f_8f59_2aeead908009
is: P42765
initial amount: NaN
name: ACAA2
is encoded by: hsa:10449
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_20ac8c1d_cbb4_44e8_9f28_4fcd361c4002
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: Q05C14
type: Species
is encoded by: hsa:2352
boundary condition: true
initial amount: NaN
name: FOLR3
constant: false

metaR R group phosphotase 2
type: Reaction
kinetic law: MODEL1310110027#
is: SBO:0000176
name: R group phosphotase 2
product: MODEL1310110027#
fast: false
reversible: false
reactant: MODEL1310110027#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110027#_40f66355_ff6d_4648_8265_6243052dde2b
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
constant: false
name: VNN3:VNN2:VNN1
is: SBO:0000297
is encoded by: hsa:55350
is encoded by: hsa:8875
has part: O95498

http://identifiers.org/biomodels.db/MODEL1310110027#_8af2ce45_9852_45b0_8a3d_bbdddb2d9fd2
is encoded by: hsa:8659
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
name: ALDH4A1
has only substance units: false
initial concentration: NaN
type: Species

metaR URATEt
type: Reaction
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
name: urate export from cytosol
product: MODEL1310110027#
reversible: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_7be731b6_9872_44a3_bb34_02ff35624b17
boundary condition: true
initial amount: NaN
is encoded by: hsa:4710
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
type: Species
is: O95168
name: NDUFB4

metaR DCSPTN1COAtx
name: fatty acid intracellular transport
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is: SBO:0000185
kinetic law: MODEL1310110027#
reversible: true
product: MODEL1310110027#
fast: false
type: Reaction
is described by: ECO:0000000

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

metaM retinal cis 9 c
type: Species
is: SBO:0000247
is: CHEBI:17898
is: HMDB01358
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
name: all-trans-retinal
initial amount: NaN
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575

metaM dcacoa m
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:61430
is: C05274
is: SBO:0000247
is: HMDB06404
name: Decanoyl-CoA (n-C10:0CoA)

http://identifiers.org/biomodels.db/MODEL1310110027#_ef6010dd_571e_4f76_85bd_d232aa112b2a
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:80025
boundary condition: true
is: Q6P1K9
name: PANK2
has only substance units: false
type: Species
is: SBO:0000252

metaR FAOXC6C4x
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6-->C4)x
type: Reaction

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

metaM anth c
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
name: anthranilate
is: CHEBI:16567
is: SBO:0000247
is: HMDB01123
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108

metaR LCTStg
is described by: ECO:0000000
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:this reaciton is only found in lactating mammary cells NCD
is: SBO:0000185
fast: false
kinetic law: MODEL1310110027#
reversible: false
type: Reaction
product: MODEL1310110027#
name: lactose transport from Golgi to extracellular (via vesicle)

metaR G14T5g
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.2) or (8704.1) or (8703.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
modifier: MODEL1310110027#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
fast: false
type: Reaction

metaR LEUt4
modifier: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
is described by: ECO:0000269
name: L-leucine transport in via sodium symport
is: SBO:0000185
reversible: false
fast: false
notes: GENE_ASSOCIATION: (81539.1) or (84889.1) or (6520.1) or (6542.1) or (6541.1) or (11254.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10391915,PMID:10891391,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:1376926,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB

metaR r1648
fast: false
product: MODEL1310110027#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
reversible: true
modifier: MODEL1310110027#
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110027#_dce921ee_b757_4211_a277_5b26d7f708b1
initial amount: NaN
name: _AI684467_1_m
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AI684467
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110027#_b713645e_8352_43c1_b14b_2ce8fd122ce0
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:230
is: P09972
constant: false
name: ALDOC
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110027#_f4f3c769_1062_42c3_bf0c_75123d5ec663
boundary condition: true
initial amount: NaN
name: TXNRD1
is encoded by: hsa:7296
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
has only substance units: false

metaM dmnoncrn c
name: 4,8-dimethylnonanoyl carnitine
type: Species
is: HMDB06202
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C18H37NO4 CHARGE: 0
constant: false
initial concentration: 1.0

metaR r1844
product: MODEL1310110027#
name: Y+LAT2 Utilized transport
type: Reaction
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110027#
modifier: MODEL1310110027#
fast: false
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaM 2maacoa m
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB01157
is: CHEBI:57335
is: SBO:0000247
name: 2-methylacetoacetyl-CoA(4-)
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
boundary condition: false
initial amount: NaN

metaR M4MPDOL Lter
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
reversible: false
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110027#
name: m4mpdol flippase
kinetic law: MODEL1310110027#
is: SBO:0000185
reactant: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_352aae9d_b3b8_451d_84ad_51a9bce0bd54
boundary condition: true
is encoded by: hsa:6818
name: SULT1A3
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252

metaR r1645
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
is: SBO:0000185
fast: false
reversible: true
type: Reaction
modifier: MODEL1310110027#
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR H2MTer L
notes: GENE_ASSOCIATION: (55650.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15623507 NOTES:NCD
reversible: false
product: MODEL1310110027#
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
is described by: ECO:0000000
name: H2 mannosyltransferase, endoplasmic reticulum
reactant: MODEL1310110027#
is: SBO:0000176
fast: false
type: Reaction

metaM gtp m
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
name: GTP
boundary condition: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: C00044
is: CHEBI:37565
is: HMDB01273
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_4872a829_fba5_4940_88b4_5ccf1b4efcc8
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:196883
boundary condition: true
initial amount: NaN
constant: false
is: Q8NFM4
name: ADCY4

metaM e4hglu m
has only substance units: false
type: Species
name: erythro-4-hydroxy-L-glutamate(1-)
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB02273
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947
boundary condition: false
constant: false
is: CHEBI:6331

metaR R group phosphotase 1
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110027#
reversible: false
reactant: MODEL1310110027#
name: R group phosphotase 1
is described by: ECO:0000000
fast: false
product: MODEL1310110027#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_86eec77f_1713_4605_a414_86b4f10ead24
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:10637
is: O75610
initial concentration: NaN
name: LEFTY1
type: Species
constant: false
has only substance units: false
boundary condition: true

metaR CO2tm
fast: false
product: MODEL1310110027#
reversible: true
kinetic law: MODEL1310110027#
name: CO2 transport (diffusion), mitochondrial
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110027#

metaR EX dcyt LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxycytidine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_7ce5a780_d858_4af4_b870_61ae03bbbc2c
is: Q6IB04
is: SBO:0000252
is encoded by: hsa:5281
name: PIGF
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

metaM 34hpp c
initial concentration: 1.0
is: CHEBI:36242
constant: false
has only substance units: false
type: Species
name: 3-(4-hydroxyphenyl)pyruvate
is: HMDB00707
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179

metaM hmgcoa c
name: Hydroxymethylglutaryl-CoA
initial amount: NaN
is: HMDB01375
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:15467
type: Species
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_d65cf198_0a69_483f_9b59_32958e1c4537
is encoded by: hsa:80308
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
name: FLAD1
is: SBO:0000252
constant: false
boundary condition: true

metaR EX tag hs LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: triacylglycerol (homo sapiens) exchange
type: Reaction

metaR MI1345PP
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.1.3.36
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
type: Reaction
fast: false
product: MODEL1310110027#
reversible: false
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.1.3.56
is: SBO:0000176
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.1.3.86
is described by: ECO:0000269

metaR PRODt2r
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
is: SBO:0000185
is described by: ECO:0000304
fast: false
reversible: true
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
product: MODEL1310110027#
type: Reaction
name: D-proline reversible transport via proton symport
modifier: MODEL1310110027#

metaM h2o2 x
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: C00027
is: SBO:0000247
name: Hydrogen peroxide
initial concentration: 1.0
is: CHEBI:16240
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
is: HMDB03125
type: Species

metaR RAtn3
name: 13-cis-retinoic acid transport, nuclear
reactant: MODEL1310110027#
is: SBO:0000185
type: Reaction
product: MODEL1310110027#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
fast: false
kinetic law: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_d9e6efd4_8d8f_4430_87c4_b6695ed23b71
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
name: _AI761708_1_m
is: SBO:0000252
is encoded by: hsa:AI761708
constant: false

metaM zymstnl r
has only substance units: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
name: 5alpha-cholest-8-en-3beta-ol
type: Species
constant: false
is: CHEBI:16608
is: SBO:0000247
boundary condition: false
is: HMDB06841
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110027#_4d73a294_8c51_4e38_9eeb_0d9e2c254dd7
initial amount: NaN
name: CHST1
boundary condition: true
is encoded by: hsa:8534
constant: false
initial concentration: NaN
is: O43916
is: SBO:0000252
has only substance units: false
type: Species

metaM gtp n
is: SBO:0000247
initial concentration: 1.0
is: HMDB01273
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
constant: false
name: GTP(4-)
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:37565
type: Species

metaR r1646
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110027#
is: SBO:0000185
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
modifier: MODEL1310110027#

metaR MM8Cg
type: Reaction
product: MODEL1310110027#
fast: false
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000000
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.2.1.113
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
notes: GENE_ASSOCIATION: (57134.1) or (10905.1) or (4121.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD

metaM mi13p c
has only substance units: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)5(17-19(11,12)13)4(10)6(3(1)9)18-20(14,15)16/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3+,4+,5+,6-
name: 1D-myo-Inositol 1,3-bisphosphate
initial concentration: 1.0
is: CHEBI:18225
boundary condition: false
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
is: HMDB06234

metaR NADtx
reversible: true
kinetic law: MODEL1310110027#
product: MODEL1310110027#
fast: false
type: Reaction
name: transport of NAD into peroxisome
is described by: ECO:0000134
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185

metaR ADK3
kinetic law: MODEL1310110027#
is described by: ECO:0000269
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.3
modifier: MODEL1310110027#
is: SBO:0000176
reactant: MODEL1310110027#
product: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
type: Reaction
name: adentylate kinase (GTP)

metaM HC02206 c
initial concentration: 1.0
is: CHEBI:57399
is: SBO:0000247
boundary condition: false
type: Species
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
initial amount: NaN
name: prostaglandin C1(1-)
has only substance units: false

metaR EX lpchol hs LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for lysophosphatidylcholine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_dc9f477f_fc45_4005_bcbb_eba9d7120c5b
is: O76062
is encoded by: hsa:7108
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
boundary condition: true
name: TM7SF2

metaR ACACtx
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
reactant: MODEL1310110027#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110027#
product: MODEL1310110027#
name: acetoacetate intracellular transport unknown mechanism
reversible: true

metaM gluside hs r
type: Species
is: CHEBI:18368
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: D-glucosyl-N-acylsphingosine

http://identifiers.org/biomodels.db/MODEL1310110027#_ab22e8dd_f31d_49ef_a7f6_c7b40762b800
is encoded by: hsa:4696
is: O95167
name: NDUFA3
initial concentration: NaN
boundary condition: true
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaR RE1530C
reactant: MODEL1310110027#
type: Reaction
name: RE1530
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
fast: false
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110027#
is described by: ECO:0000000
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_171e8ece_9a49_4f7e_97b5_4916a4dcf857
is encoded by: hsa:5332
initial concentration: NaN
initial amount: NaN
name: PLCB4
constant: false
type: Species
is: E2QRH8
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR r1643
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
fast: false
reversible: true
type: Reaction
is: SBO:0000185
product: MODEL1310110027#
modifier: MODEL1310110027#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110027#_ba8fa008_5efc_45bd_bb21_381457e3fe45
has part: Q92535
is encoded by: hsa:8818
type: Species
is encoded by: hsa:9091
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
has part: O94777
has only substance units: false
is encoded by: hsa:5283
is encoded by: hsa:51227
has part: Q14442
is: SBO:0000297
initial concentration: NaN
constant: false
is encoded by: hsa:5277
is encoded by: hsa:5279
has part: B3KUV7
boundary condition: true
initial amount: NaN
has part: Q9BRB3

http://identifiers.org/biomodels.db/MODEL1310110027#_cecfd299_3b8b_4296_ac5e_8e8c4126cd4a
constant: false
is encoded by: hsa:51079
has only substance units: false
initial concentration: NaN
name: NDUFA13
type: Species
is: SBO:0000252
boundary condition: true
is: Q9P0J0
initial amount: NaN

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type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1716
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
name: DGUOK

metaM lcts g
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3-,4-,5+,6+,7-,8-,9-,10-,11?,12+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00220 EHMN_ABBREVIATION: C00243
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17716
is: HMDB00186
name: lactose
type: Species

metaM q10h2 e
name: Ubiquinol-10
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/6504740
has only substance units: false
is: HMDB13111
initial amount: NaN
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
type: Species

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_9e6c3522_bdad_4dad_8ded_05c162d7e7e0
is encoded by: hsa:221823
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: PRPS1L1
constant: false
type: Species

metaM ptth m
is: SBO:0000247
is: CHEBI:16753
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
name: pantetheine
is: HMDB03426
initial amount: NaN
type: Species
initial concentration: 1.0

metaM 34hpp e
boundary condition: false
constant: false
is: CHEBI:36242
type: Species
initial concentration: 1.0
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
name: 3-(4-hydroxyphenyl)pyruvate
has only substance units: false
initial amount: NaN
is: HMDB00707
is: SBO:0000247

metaM mi1p D c
is: HMDB02985
is: CHEBI:58433
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
name: 1D-myo-inositol 1-phosphate(2-)

metaM 4hphac e
name: 4-hydroxyphenylacetate
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
is: CHEBI:48999
is: HMDB00020
constant: false

metaM tststerone c
is: CHEBI:17347
constant: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
initial amount: NaN
is: HMDB00234
has only substance units: false
name: testosterone
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110027#_392a3b9e_a20c_4405_ab3f_243f4388589f
constant: false
is encoded by: hsa:224
initial concentration: NaN
type: Species
initial amount: NaN
name: ALDH3A2
boundary condition: true
has only substance units: false
is: P51648
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110027#_2dbed4ef_e1fa_48f3_86f6_66b9c26a909b
boundary condition: true
is: SBO:0000252
is encoded by: hsa:124454
constant: false
name: EARS2
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: Q5JPH6

metaM 4hphac c
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:48999
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB00020
boundary condition: false
name: 4-hydroxyphenylacetate

metaR FAOXC142C122m
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_d79c6ca3_94c1_4798_ba2e_ffd759fd8375
is encoded by: hsa:114134
initial concentration: NaN
initial amount: NaN
name: SLC2A13
constant: false
type: Species
is: SBO:0000252
has only substance units: false
is: Q96QE2
boundary condition: true

metaR DOLPMT2 Ler
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110027#
is: SBO:0000176
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
product: MODEL1310110027#
is described by: ECO:0000000
kinetic law: MODEL1310110027#
type: Reaction

metaR RE3524R
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
kinetic law: MODEL1310110027#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110027#
name: RE3524
reactant: MODEL1310110027#
type: Reaction
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110027#_583f432a_a03b_40bb_9d1b_5da90b1258e5
type: Species
is encoded by: hsa:5286
is: O00443
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
name: PIK3C2A

metaR r1644
reversible: true
modifier: MODEL1310110027#
type: Reaction
product: MODEL1310110027#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#

metaM pep c
name: Phosphoenolpyruvate
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
constant: false
is: CHEBI:18021
is: C00074
initial concentration: 1.0
is: HMDB00263
type: Species
initial amount: NaN

metaM mi14p c
has only substance units: false
initial amount: NaN
is: HMDB00968
boundary condition: false
is: SBO:0000247
constant: false
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
initial concentration: 1.0
type: Species
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
is: CHEBI:58282

metaM CE4792 m
has only substance units: false
type: Species
is: CHEBI:57923
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-22,24,28-30,34,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4792
is: SBO:0000247
name: 3-oxo-cis-8-tetradecenoyl-CoA
initial amount: NaN

metaM dgdp c
constant: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58595
type: Species
is: HMDB00960
has only substance units: false
is: C00361
name: dGDP

metaR ADNCYC
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/4.6.1.1
product: MODEL1310110027#
reactant: MODEL1310110027#
type: Reaction
fast: false
is: SBO:0000176
is described by: ECO:0000269
name: adenylate cyclase
reversible: false
notes: GENE_ASSOCIATION: (112.1) or (55811.1) or (109.1) or (112.2) or (114.1) or (108.1) or (113.1) or (107.1) or (196883.1) or (115.1) or (111.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.1 Confidence Level: 4 AUTHORS: PMID:10481931,PMID:11299302,PMID:11423534,PMID:11840511,PMID:12503609,PMID:12609998,PMID:12623444,PMID:1427768,PMID:14996950,PMID:15547246,PMID:7860067,PMID:7959689,PMID:8076676 NOTES:JLR
kinetic law: MODEL1310110027#

metaR O2t
product: MODEL1310110027#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110027#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
is: SBO:0000185
kinetic law: MODEL1310110027#
type: Reaction
name: o2 transport (diffusion)

http://identifiers.org/biomodels.db/MODEL1310110027#_89649b70_03b0_4bbd_ae71_0c1f02bdf2d4
constant: false
type: Species
initial concentration: NaN
boundary condition: true
is: Q04828
has only substance units: false
is: SBO:0000252
name: AKR1C1
is encoded by: hsa:1645
initial amount: NaN

metaM sarcs m
is: CHEBI:15611
name: Sarcosine
is: C00213
is: HMDB00271
type: Species
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C3H7NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
boundary condition: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_d1a2b1e6_ad80_424b_bd0b_1f160752e33e
is: P27986
is encoded by: hsa:5295
is: SBO:0000252
has only substance units: false
boundary condition: true
name: PIK3R1
initial concentration: NaN
initial amount: NaN
type: Species
constant: false

metaR r0829
reactant: MODEL1310110027#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/4.1.1.37
is: SBO:0000185
type: Reaction
product: MODEL1310110027#

metaM HC02206 e
has only substance units: false
is: CHEBI:57399
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
name: prostaglandin C1(1-)

http://identifiers.org/biomodels.db/MODEL1310110027#_9d92cfaa_d89a_464f_bb3f_85f0155b8193
is: Q9HAB8
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:79717
boundary condition: true
name: PPCS
initial amount: NaN
is: SBO:0000252
type: Species

metaR RE1901R
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799,PMID:11279029 NOTES:
reactant: MODEL1310110027#
is described by: ECO:0000000
product: MODEL1310110027#
kinetic law: MODEL1310110027#
name: RE1901
type: Reaction
is: SBO:0000176
reversible: true
fast: false

metaR EX HC02205 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b2 exchange
type: Reaction

metaM glx c
has only substance units: false
boundary condition: false
name: glyoxylate
type: Species
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
is: CHEBI:36655
initial amount: NaN
is: HMDB00119
constant: false
is: SBO:0000247
initial concentration: 1.0

metaM m8masn g
boundary condition: false
initial concentration: 1.0
is: C05876
is: SBO:0000247
has only substance units: false
constant: false
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
type: Species
notes: FORMULA: C70H117N2O55X CHARGE: 0
initial amount: NaN

metaM gdp m
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: HMDB01201
is: CHEBI:58189
has only substance units: false
is: SBO:0000247
name: GDP
initial concentration: 1.0
is: C00035
boundary condition: false

metaR r1641
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110027#
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110027#
fast: false

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

metaR RAI1
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
type: Reaction
product: MODEL1310110027#
name: retinal isomerase (11-cis)
kinetic law: MODEL1310110027#
reversible: true
fast: false
is: SBO:0000176
reactant: MODEL1310110027#
is described by: ECO:0000000

metaM 5adtststerone e
has only substance units: false
type: Species
name: 17beta-hydroxy-5alpha-androstan-3-one
is: HMDB02961
is: CHEBI:16330
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
initial concentration: 1.0

metaR PROSTGE2t
reversible: true
name: prostaglandin transport via bicarbonate countertransport
reactant: MODEL1310110027#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
product: MODEL1310110027#

metaR RAI2
is described by: ECO:0000000
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
product: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
name: retinal isomerase (9-cis)
type: Reaction
reversible: true
is: SBO:0000176

metaM fgam c
constant: false
notes: FORMULA: C8H13N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01281 EHMN_ABBREVIATION: C04376
is: CHEBI:58426
initial concentration: 1.0
has only substance units: false
is: HMDB01308
is: SBO:0000247
initial amount: NaN
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide
is: C04376
type: Species
boundary condition: false

metaM lcts e
has only substance units: false
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00220 EHMN_ABBREVIATION: C00243
name: Lactose
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17716
is: HMDB00186
is: C00243
type: Species

metaR SUCCCROT
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of succinyl carnitine
type: Reaction

metaR H8TAer
type: Reaction
is: SBO:0000176
name: H8 transamidase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (10026.1) and (8733.1) and (128869.1) and (94005.1) and (51604.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10727241,PMID:11483512,PMID:12802054,PMID:15632136,PMID:9356492,PMID:9468317 NOTES:EC 2.6.-.- NCD
fast: false
product: MODEL1310110027#
reactant: MODEL1310110027#
reversible: false
modifier: MODEL1310110027#
is described by: ECO:0000000
kinetic law: MODEL1310110027#

metaR FAOXC16C14m
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16-->C14)m
type: Reaction

metaM tststerone e
is: CHEBI:17347
constant: false
initial amount: NaN
is: HMDB00234
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
is: SBO:0000247
type: Species
name: testosterone
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaM glyc3p m
constant: false
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
initial amount: NaN
is: HMDB00126
is: C00093
type: Species
is: SBO:0000247
name: Glycerol 3-phosphate
is: CHEBI:57597
initial concentration: 1.0
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110027#_5b3ce8f5_671e_4d1b_b7cb_4062db8f2fc5
constant: false
has only substance units: false
is encoded by: hsa:6817
type: Species
boundary condition: true
initial concentration: NaN
name: SULT1A1
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_12073ccb_a58a_4594_a761_ce66dcced1fe
is: SBO:0000252
name: SULT1A1
constant: false
is encoded by: hsa:6817
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: P50225
type: Species

metaR r2050
product: MODEL1310110027#
reversible: false
modifier: MODEL1310110027#
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110027#
type: Reaction
fast: false
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR BGLUTCHLe
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: binding of betaglucans with taurocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

metaM leuktrE4 c
is: HMDB02200
is: CHEBI:57462
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
name: leukotriene E4(1-)
has only substance units: false
is: SBO:0000247
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
constant: false

metaM dhea r
name: 3beta-hydroxyandrost-5-en-17-one
boundary condition: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C01227
has only substance units: false
is: HMDB00077
constant: false
is: CHEBI:28689
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR TRPHYDRO2
is version of: http://identifiers.org/ec-code/1.14.16.4
kinetic law: MODEL1310110027#
is described by: ECO:0000269
fast: false
product: MODEL1310110027#
reversible: false
is: SBO:0000176
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (7166.1) or (121278.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.16.4 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:12379098 NOTES:SAB unlumped version of TRPHYDRO1
type: Reaction
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
reactant: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_d6e8ff36_188b_4cd5_ae23_e2a9e0ef1d28
has part: Q15102
initial amount: NaN
has part: A8DPS7
is encoded by: hsa:5050
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5049
is: SBO:0000297
has only substance units: false
name: PAFAH1B2:PAFAH1B3
type: Species

metaM gdp n
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
name: GDP(3-)
is: HMDB01201
is: CHEBI:58189
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0

metaR r1642
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
modifier: MODEL1310110027#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110027#
kinetic law: MODEL1310110027#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110027#

metaR ICDHxm
fast: false
reactant: MODEL1310110027#
product: MODEL1310110027#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.1.1.41
is described by: ECO:0000134
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (3421.2 and 3420.3 and 3419.1) or (3420.1 and 3421.1 and 3419.1) or (3420.1 and 3421.1 and 3419.1) or (3420.3 and 3421.1 and 3419.1) or (3421.1 and 3419.1 and 3420.2) or (3421.2 and 3419.1 and 3420.2) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.41 Confidence Level: 0 AUTHORS: PMID:10601238,PMID:14555658 NOTES:The reaction may be reversible. Strathern shows the reactions as irreversible. IF. Biochemical, Genetic
reversible: false
name: Isocitrate dehydrogenase (NAD+)

metaR 2MCITt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:426765 NOTES:MM
fast: false
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
is: SBO:0000185
product: MODEL1310110027#
name: 2-methylcitrate transport via diffusion

metaM anth e
is: CHEBI:16567
initial amount: NaN
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB01123
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
has only substance units: false
name: anthranilate

metaM dctp c
initial amount: NaN
constant: false
is: CHEBI:16311
name: dCTP
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB00998
is: C00458
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_7f6633f4_9922_4ea5_81f1_5a50986d5159
name: DGKH
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:160851
is: A8K0I1
constant: false
initial concentration: NaN
has only substance units: false

metaM pail34p hs c
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:57658
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
type: Species
constant: false
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)
initial concentration: 1.0

metaR GLXO1
product: MODEL1310110027#
is described by: ECO:0000269
name: glyoxylate oxidase
is version of: http://identifiers.org/ec-code/1.1.1.27
notes: GENE_ASSOCIATION: (3939.1) or (55293.1) or (3945.1 and 3939.1) or (197257.1) or (92483.1) or (3945.1) or (160287.1) or (3948.1) or (197257.2) or (3948.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.3.5 Confidence Level: 4 AUTHORS: PMID:12768081,PMID:9038835,PMID:9604807,PMID:9783918 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110027#
reversible: false
kinetic law: MODEL1310110027#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.2.4
modifier: MODEL1310110027#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110027#_365541ff_b54e_4c43_858d_ba4588798849
name: ALDH7A1
is: E7EPT3
is: SBO:0000252
is encoded by: hsa:501
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false

metaM HC01444 e
name: Galactosylglycerol
boundary condition: false
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
constant: false
has only substance units: false
is: CHEBI:15754
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaM 3mox4hpac m
notes: FORMULA: C9H10O3 CHARGE: 0 INCHI: InChI=1S/C9H10O3/c1-12-9-6-7(4-5-10)2-3-8(9)11/h2-3,5-6,11H,4H2,1H3 HEPATONET_1.0_ABBREVIATION: HC01518 EHMN_ABBREVIATION: C05581
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
name: (4-hydroxy-3-methoxyphenyl)acetaldehyde
initial amount: NaN
is: CHEBI:28111
has only substance units: false
is: HMDB05175
boundary condition: false

metaR r1847
name: Y+LAT2 Utilized transport
type: Reaction
is: SBO:0000185
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110027#
fast: false

metaR M1316Mg
fast: false
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
product: MODEL1310110027#
type: Reaction
modifier: MODEL1310110027#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4124.1) or (4122.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.114 Confidence Level: 0 AUTHORS: PMID:8524845 NOTES:NCD
reversible: false
name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.114

metaM nh4 n
initial amount: NaN
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial concentration: 1.0
type: Species
name: ammonium
is: SBO:0000247
constant: false
is: CHEBI:28938
has only substance units: false
boundary condition: false
is: HMDB00051

metaR SPC HSt
reversible: true
reactant: MODEL1310110027#
is described by: ECO:0000000
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069827 NOTES:
type: Reaction
name: sphingosylphosphorylcholine transport (diffusion)
kinetic law: MODEL1310110027#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110027#_9c2b52b0_0e8e_4e96_9e64_8cc5e351cf8d
boundary condition: true
is encoded by: hsa:6509
name: SLC1A4
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
is: P43007
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_ceb26e77_7029_4fb9_9e48_b1ff5fe5b16f
constant: false
initial concentration: NaN
is encoded by: hsa:760
is: SBO:0000252
has only substance units: false
name: CA2
is: P00918
type: Species
initial amount: NaN
boundary condition: true

metaM ksii core2 deg6 l
constant: false
initial amount: NaN
notes: FORMULA: C44H72N4O33SX CHARGE: -1
is: SBO:0000247
name: keratan sulfate II (core 2-linked), degradation product 6
is: CHEBI:12936
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
is: HMDB00143

metaR TMDK1
name: thymidine kinase (ATP:thymidine)
is version of: http://identifiers.org/ec-code/2.7.1.21
modifier: MODEL1310110027#
is: SBO:0000176
type: Reaction
product: MODEL1310110027#
reversible: false
notes: GENE_ASSOCIATION: (7084.1) or (7083.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#

metaR RE1691M
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110027#
reactant: MODEL1310110027#
is: SBO:0000176
notes: GENE_ASSOCIATION: (7263.1) SUBSYSTEM: Miscellaneous EC Number: 2.8.1.1 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:9070219 NOTES:
fast: false
name: RE1691
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.1.1

metaM nh4 m
is: HMDB00051
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial amount: NaN
is: C01342
type: Species
constant: false
name: Ammonium
is: CHEBI:28938

http://identifiers.org/biomodels.db/MODEL1310110027#_5d04c418_8505_49b0_8c96_538243448fbe
is encoded by: hsa:4351
initial concentration: NaN
name: MPI
initial amount: NaN
type: Species
constant: false
boundary condition: true
is: P34949
has only substance units: false
is: SBO:0000252

metaR r2114
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110027#
is: SBO:0000185
kinetic law: MODEL1310110027#
fast: false
modifier: MODEL1310110027#
reactant: MODEL1310110027#

metaM nad c
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00902
is: CHEBI:57540
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/3305
is: C00003
name: Nicotinamide adenine dinucleotide
constant: false
initial amount: NaN

metaM dmnoncrn m
name: 4,8 dimethylnonanoyl carnitine
notes: FORMULA: C18H37NO4 CHARGE: 0 INCHI: InChI=1/C18H35NO4/c1-14(2)8-7-9-15(3)10-11-18(22)23-16(12-17(20)21)13-19(4,5)6/h14-16H,7-13H2,1-6H3
constant: false
has only substance units: false
initial amount: NaN
is: HMDB06202
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0

metaR EX c4crn
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for butyryl carnitine
type: Reaction

metaM lnlc r
is: HMDB00673
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC00796 EHMN_ABBREVIATION: C01595
constant: false
name: linoleate
boundary condition: false
has only substance units: false
is: CHEBI:30245

http://identifiers.org/biomodels.db/MODEL1310110027#_ae494b2e_7431_409e_ac33_43f540818a2d
name: HK3
initial amount: NaN
has only substance units: false
is encoded by: hsa:3101
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
is: P52790

http://identifiers.org/biomodels.db/MODEL1310110027#_c249885e_ae74_4a0e_ac12_7dc1fb9a66bf
is: Q01433
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
name: AMPD2
initial amount: NaN
boundary condition: true
is encoded by: hsa:271
has only substance units: false

metaM sucsal m
initial amount: NaN
is: HMDB01259
initial concentration: 1.0
is: SBO:0000247
name: Succinic semialdehyde
has only substance units: false
is: CHEBI:57706
type: Species
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
constant: false
boundary condition: false

metaR S23T2g
is described by: ECO:0000000
reactant: MODEL1310110027#
modifier: MODEL1310110027#
reversible: false
kinetic law: MODEL1310110027#
fast: false
product: MODEL1310110027#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.99.4
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
is: SBO:0000176
name: beta-galactoside alpha-2,3-sialyltransferase (core 2)

metaR MECOAS1m
product: MODEL1310110027#
name: mesaconate--CoA ligase (GDP-forming)
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
reactant: MODEL1310110027#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/6.2.1.4
kinetic law: MODEL1310110027#
fast: false
reversible: true

metaR STS1
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Steroid metabolism EC Number: 3.1.6.2 Confidence Level: 4 AUTHORS: PMID:2668275,PMID:6957717 NOTES:NJ
modifier: MODEL1310110027#
reactant: MODEL1310110027#
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.2
is: SBO:0000176
name: Steryl-sulfatase
product: MODEL1310110027#
kinetic law: MODEL1310110027#
is described by: ECO:0000269
reversible: false
type: Reaction

metaM fprica c
has only substance units: false
is: SBO:0000247
is: C04734
initial amount: NaN
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
constant: false
type: Species
notes: FORMULA: C10H13N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01344 EHMN_ABBREVIATION: C04734
is: CHEBI:58467
initial concentration: 1.0
is: HMDB01439
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110027#_50376219_daee_497d_8cea_7064544a559d
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: Q4J699
boundary condition: true
name: ATP2B2
is encoded by: hsa:491
initial concentration: NaN
constant: false
type: Species

metaR RE2973C
reactant: MODEL1310110027#
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (5290.1) or (5291.1) or (5294.1) or (5289.1) or (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:
kinetic law: MODEL1310110027#
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.11.1
is: SBO:0000176
product: MODEL1310110027#
type: Reaction
name: RE2973
is version of: http://identifiers.org/ec-code/2.7.1.137
is version of: http://identifiers.org/ec-code/2.7.1.153
is version of: http://identifiers.org/ec-code/2.7.1.154
fast: false

metaR GALASE16ly
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false
name: beta-galactosidase, lysosomal
reactant: MODEL1310110027#
type: Reaction
product: MODEL1310110027#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110027#_673ce506_1ddf_4196_8ac6_638631620b93
name: PAFAH1B2
is encoded by: hsa:5049
initial amount: NaN
has only substance units: false
is: A8DPS7
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110027#_1e1d3591_4cc9_4d3b_a1bf_c60dc88ee8d8
is encoded by: hsa:275
name: DLD:GCSH:GLDC:AMT
has part: P48728
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
has part: P09622
constant: false
is: SBO:0000297
has only substance units: false
is encoded by: hsa:1738
has part: P23434
is encoded by: hsa:2653
is encoded by: hsa:2731
has part: P23378

http://identifiers.org/biomodels.db/MODEL1310110027#_9de085e0_da1e_4159_9db0_a68ad2119f37
has only substance units: false
is encoded by: hsa:7841
initial amount: NaN
initial concentration: NaN
constant: false
is: F5H6D0
boundary condition: true
is: SBO:0000252
type: Species
name: MOGS

http://identifiers.org/biomodels.db/MODEL1310110027#_7b0cb478_30a7_437b_a996_9844d575c1e3
type: Species
is: Q9NVF9
name: ETNK2
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:55224
has only substance units: false

metaR EX Lcystin LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Cystine exchange
type: Reaction

metaM ksi pre19 g
is: CHEBI:58053
is: C00130
is: HMDB00175
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 19
notes: FORMULA: C171H275N12O137S5X CHARGE: -6
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110027#_062c86d8_de25_47f9_bc9c_1eac3e59cfbf
is: P19404
name: NDUFV2
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4729
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false

metaM nicrnt c
is: SBO:0000247
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
constant: false
name: Nicotinate D-ribonucleotide
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:57502
is: C01185
boundary condition: false
is: HMDB01132

metaR r2115
fast: false
modifier: MODEL1310110027#
product: MODEL1310110027#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
type: Reaction
reversible: true
is described by: ECO:0000000

metaR GLCter
is: SBO:0000185
reactant: MODEL1310110027#
product: MODEL1310110027#
reversible: true
kinetic law: MODEL1310110027#
fast: false
name: glucose transport, endoplasmic reticulum
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD
type: Reaction

metaM pail4p hs n
type: Species
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:58178
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
initial amount: NaN
initial concentration: 1.0

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

metaR RE2660N
name: RE2660
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
reversible: true
kinetic law: MODEL1310110027#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/4.2.1.96
product: MODEL1310110027#
fast: false
type: Reaction
modifier: MODEL1310110027#

metaR r1640
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110027#
reversible: true
is: SBO:0000185
product: MODEL1310110027#
is described by: ECO:0000000
reactant: MODEL1310110027#
modifier: MODEL1310110027#

metaR PRO1xm
is version of: http://identifiers.org/ec-code/1.5.99.8
reversible: false
name: proline oxidase (NAD), mitochondrial
reactant: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:NCD
fast: false
is described by: ECO:0000254
is: SBO:0000176
modifier: MODEL1310110027#

metaR GALt1r
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (29988.1) or (6513.1) or (6515.1) or (6514.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860996,PMID:11247674,PMID:11592815,PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:NCD
reversible: true
product: MODEL1310110027#
type: Reaction
reactant: MODEL1310110027#
is described by: ECO:0000269
fast: false
name: galactose transport (uniport)
kinetic law: MODEL1310110027#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110027#_971abcf8_5485_4d05_84aa_890c14ac7de9
boundary condition: true
type: Species
has part: P43034
is: SBO:0000297
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:5048
name: PAFAH1B1:PAFAH1B2:PAFAH1B3
initial amount: NaN

metaM leuktrE4 e
boundary condition: false
constant: false
is: HMDB02200
is: SBO:0000247
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57462
has only substance units: false
name: leukotriene E4(1-)

metaR EX ala D LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Alanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_a3fcf291_79c7_4670_9bb5_6e50402fa7f1
is: P37837
boundary condition: true
name: TALDO1
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:6888
initial concentration: NaN
is: SBO:0000252
type: Species

metaR FERO
type: Reaction
notes: GENE_ASSOCIATION: (9843.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
product: MODEL1310110027#
reversible: false
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
is: SBO:0000176
fast: false
name: ferroxidase
is described by: ECO:0000134
reactant: MODEL1310110027#

metaM ksi pre26 g
name: keratan sulfate I biosynthesis, precursor 26
initial concentration: 1.0
is: CHEBI:28067
constant: false
notes: FORMULA: C199H318N14O166S8X CHARGE: -9
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_434c6724_f468_40f0_ae8e_66b90263925d
is: SBO:0000252
type: Species
initial concentration: NaN
name: _BE966236_1_c
constant: false
boundary condition: true
is encoded by: hsa:BE966236
initial amount: NaN
has only substance units: false

metaR NAGA2ly
is described by: ECO:0000000
modifier: MODEL1310110027#
reversible: false
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
is version of: http://identifiers.org/ec-code/3.2.1.49
type: Reaction
name: N-acetylgalactosaminidase, alpha-
product: MODEL1310110027#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110027#_611a4859_f4cf_4376_81b8_6e26289cdfb8
has only substance units: false
name: GMPS
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
is: P49915
boundary condition: true
is encoded by: hsa:8833
type: Species

metaR C226CRNt
reactant: MODEL1310110027#
name: C226 transport into the mitochondria
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
type: Reaction
is described by: ECO:0000000
product: MODEL1310110027#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110027#

metaM gluside hs c
is: CHEBI:18368
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
initial concentration: 1.0
has only substance units: false
name: D-glucosyl-N-acylsphingosine

http://identifiers.org/biomodels.db/MODEL1310110027#_954885e5_f020_45d5_b14e_666c2fb994a8
name: GALNT3
is: SBO:0000252
is: Q14435
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:2591

metaR r2112
reactant: MODEL1310110027#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
product: MODEL1310110027#
is described by: ECO:0000000
kinetic law: MODEL1310110027#
is: SBO:0000185
modifier: MODEL1310110027#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM ksi pre17 g
boundary condition: false
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 17
notes: FORMULA: C157H252N11O127S5X CHARGE: -6
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
is: CHEBI:28067

metaM dctp n
name: dCTP
is: C00458
has only substance units: false
is: CHEBI:16311
constant: false
type: Species
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
initial amount: NaN
is: SBO:0000247
is: HMDB00998
boundary condition: false
initial concentration: 1.0

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

metaM q10h2 c
name: Ubiquinol-10
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/6504740
is: HMDB13111
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_6e131dd5_99fb_4fe5_99ce_a3aeffe4d89d
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
name: ALAS1
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:211
is: P13196

metaM pail35p hs c
constant: false
boundary condition: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
type: Species
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
is: CHEBI:57923
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaR ALASm
is version of: http://identifiers.org/ec-code/2.3.1.29
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD
reactant: MODEL1310110027#
is described by: ECO:0000254
modifier: MODEL1310110027#
reversible: false
name: 5-aminolevulinate synthase
type: Reaction
product: MODEL1310110027#
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.3.1.37

metaM tre e
type: Species
is: CHEBI:16551
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: C01083
is: HMDB00975
initial amount: NaN
boundary condition: false
constant: false
name: Trehalose
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00658 EHMN_ABBREVIATION: C01083

metaR MI4PP
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
modifier: MODEL1310110027#
reversible: false
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.25
fast: false
name: myo-inositol 4-phosphatase
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
is: SBO:0000176

metaM c6crn x
constant: false
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
name: hexanoyl carnitine
notes: FORMULA: C13H25NO4 CHARGE: 0
is: HMDB00705
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_b59d67f8_1916_4e68_9706_765d5240d6af
initial amount: NaN
type: Species
name: PIK3R1
boundary condition: true
is encoded by: hsa:5295
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
is: E7EX19

http://identifiers.org/biomodels.db/MODEL1310110027#_618eea34_529c_4fcc_9d5c_14a2be4d314e
initial amount: NaN
initial concentration: NaN
is: P50226
name: SULT1A2
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
type: Species
is encoded by: hsa:6799

metaR APAT2rm
is described by: ECO:0000212
reactant: MODEL1310110027#
fast: false
modifier: MODEL1310110027#
name: 3-Aminopropanoate:2-oxoglutarate aminotransferase (m)
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 2.6.19.4 Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110027#
product: MODEL1310110027#
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.19

http://identifiers.org/biomodels.db/MODEL1310110027#_9434cc49_4c24_47cc_9d39_f0d21e5d80e5
name: RFK
initial amount: NaN
type: Species
is encoded by: hsa:55312
boundary condition: true
is: B2RDZ2
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110027#_555ee0ca_615d_48c3_a462_3da3b5ab7843
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:2194
initial concentration: NaN
name: FASN
type: Species
initial amount: NaN
is: P49327
is: SBO:0000252

metaR GLYt7 311 r
modifier: MODEL1310110027#
name: glycine reversible transport via sodium and chloride symport (3:1:1)
fast: false
is described by: ECO:0000006
is: SBO:0000185
kinetic law: MODEL1310110027#
reversible: true
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
product: MODEL1310110027#
type: Reaction

metaR PHYCBOXL
reversible: false
kinetic law: MODEL1310110027#
is described by: ECO:0000212
is: SBO:0000176
fast: false
type: Reaction
modifier: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
name: L-Phenylalanine carboxy-lyase
is version of: http://identifiers.org/ec-code/4.1.1.28
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 4.1.1.28 Confidence Level: 1 AUTHORS: NOTES:SAB

metaM m8masn r
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C70H117N2O55X CHARGE: 0
is: C05876
type: Species
boundary condition: false
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)

metaM adrncoa c
is: SBO:0000247
is: C16170
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205480
has only substance units: false
boundary condition: false
initial amount: NaN
name: adrenyl coenzyme A
constant: false

metaR CERT2gt
reactant: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
is: SBO:0000185
fast: false
is described by: ECO:0000000
name: ceramide transport protein
product: MODEL1310110027#
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.11.1

metaR r2113
product: MODEL1310110027#
fast: false
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110027#
reversible: true
is: SBO:0000185
modifier: MODEL1310110027#
type: Reaction

metaM xol7ah2al c
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
type: Species
has only substance units: false
is: HMDB06894
is: SBO:0000247
is: CHEBI:27428
constant: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445

http://identifiers.org/biomodels.db/MODEL1310110027#_b68a03f7_1166_4a14_81bb_28a4164e09ff
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:377841
constant: false
is: Q5MY95
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
name: ENTPD8

http://identifiers.org/biomodels.db/MODEL1310110027#_2a89efba_a78c_46f3_ae86_49b295d6bbb3
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:23236
name: PLCB1
is: SBO:0000252

metaM n2m2masn g
type: Species
has only substance units: false
name: ((N-acetyl-D-glucosaminyl)2-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C50H83N4O35X CHARGE: 0
is: SBO:0000247
initial amount: NaN
constant: false
is: C11530

metaR RIBt
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
reversible: true
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
fast: false
name: ribose transport via diffusion
is described by: ECO:0000000
is: SBO:0000185

metaM sarcs c
is: C00213
name: Sarcosine
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:3513
notes: FORMULA: C3H7NO2 CHARGE: 0
initial concentration: 1.0
has only substance units: false
is: HMDB00271
type: Species

metaR CITRtm
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
modifier: MODEL1310110027#
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110027#
product: MODEL1310110027#
name: citrulline mitochondrial transport via proton antiport
fast: false
is described by: ECO:0000269

metaR r0527
name: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
product: MODEL1310110027#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:
type: Reaction
reversible: true
reactant: MODEL1310110027#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_97247f38_18b3_4c2d_a432_e4416c1d00b7
is encoded by: hsa:56922
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: MCCC1
is: SBO:0000252
is: Q96RQ3
constant: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_cdfdfaef_8140_417f_b690_9fe0010839f4
type: Species
is: O95861
initial concentration: NaN
constant: false
is encoded by: hsa:10380
name: BPNT1
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR UMPK6n
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110027#
is described by: ECO:0000269
type: Reaction
name: UMP kinase (dCTP),nuclear
reversible: true
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110027#
reactant: MODEL1310110027#
fast: false
is: SBO:0000176

metaM sebcoa x
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/16019966
is: SBO:0000247
boundary condition: false
name: sebacoylcoa
initial amount: NaN
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
type: Species
constant: false
has only substance units: false

metaR r1912
is: SBO:0000185
fast: false
kinetic law: MODEL1310110027#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110027#
modifier: MODEL1310110027#
product: MODEL1310110027#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction

metaR r1538
product: MODEL1310110027#
fast: false
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
is version of: http://identifiers.org/ec-code/1.17.4.1
name: Anion Exchanger (AE) TCDB:2.A.31.2.8
is described by: ECO:0000000
is: SBO:0000185
reversible: false
type: Reaction

metaR CITtam
product: MODEL1310110027#
name: citrate transport, mitochondrial
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
modifier: MODEL1310110027#
fast: false
kinetic law: MODEL1310110027#
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
reversible: true
reactant: MODEL1310110027#

metaR r2110
modifier: MODEL1310110027#
type: Reaction
fast: false
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110027#
reversible: true
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reactant: MODEL1310110027#

metaR CSm
type: Reaction
notes: GENE_ASSOCIATION: (1431.1) or (1431.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.7 Confidence Level: 0 AUTHORS: PMID:16006620,PMID:9933076 NOTES:IF old EC number (4.1.3.7) is obsolete -- transferred to 2.3.3.1 NCD. Biochemical
kinetic law: MODEL1310110027#
fast: false
product: MODEL1310110027#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.3.3.1
reactant: MODEL1310110027#
modifier: MODEL1310110027#
is: SBO:0000176
reversible: false
name: citrate synthase

http://identifiers.org/biomodels.db/MODEL1310110027#_c9e74e50_04b4_4945_a1d8_828d4c954445
is: SBO:0000252
initial amount: NaN
is: Q9NS82
type: Species
name: SLC7A10
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:56301

metaR CYTK7
reactant: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110027#
reversible: true
name: cytidylate kinase (CMP,UTP)
is described by: ECO:0000269
product: MODEL1310110027#
fast: false
modifier: MODEL1310110027#
is: SBO:0000176

metaR ECOAH12m
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110027#
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110027#
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity

metaR CYTK6
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
modifier: MODEL1310110027#
name: cytidylate kinase (CMP,CTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
reactant: MODEL1310110027#
product: MODEL1310110027#
kinetic law: MODEL1310110027#
is described by: ECO:0000269
type: Reaction

metaR r2332
reversible: true
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110027#
kinetic law: MODEL1310110027#
is: SBO:0000185
fast: false
reactant: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_ba615f9d_df75_4e76_b2de_1958fc0025c5
constant: false
name: ME3
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is: Q6TCH8
is encoded by: hsa:10873
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110027#_9f015b84_88e6_43a7_9eab_645c56a9e632
constant: false
boundary condition: true
is encoded by: hsa:LOC727762
has only substance units: false
name: _LOC727762_1_m
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110027#_6251c33f_877e_4956_9f63_418ee88906c6
initial concentration: NaN
name: ENPP3
is: Q308M7
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:5169
is: SBO:0000252
type: Species

metaR FUMtm
reversible: true
fast: false
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV
is described by: ECO:0000269
name: fumarate transport, mitochondrial
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
product: MODEL1310110027#
is: SBO:0000185
modifier: MODEL1310110027#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_54088f59_0126_440e_94f7_9568c6a16190
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AI971036
has only substance units: false
name: _AI971036_1_m
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_6552fac1_ddb8_4d92_b38e_71ad0f78e30e
is: SBO:0000297
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
has part: O00459
is encoded by: hsa:5296
is encoded by: hsa:5290
has only substance units: false
boundary condition: true
name: PIK3CA:PIK3R2
has part: P42336

metaM pyr m
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: pyruvate
type: Species
is: http://identifiers.org/pubchem.compound/3324
initial concentration: 1.0
boundary condition: false
is: HMDB00243
is: C00022
is: CHEBI:15361
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022

metaM mlthf c
is: HMDB01533
name: 5,10-Methylenetetrahydrofolate
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
is: C00143
is: SBO:0000247
is: CHEBI:15636
constant: false
initial amount: NaN
type: Species

metaR r1913
modifier: MODEL1310110027#
reversible: false
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
name: Y+LAT2 Utilized transport
is: SBO:0000185
fast: false
product: MODEL1310110027#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110027#_bfb9bd3e_db39_4b7c_bf81_b439967f68fc
constant: false
initial amount: NaN
name: ACPP
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:55
is: P15309
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_f1776c19_1788_4d53_adac_68f01861ea93
name: SLC17A4
is: Q9Y2C5
boundary condition: true
is encoded by: hsa:10050
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false

metaM 4hexdtricoa m
is: HMDB02288
constant: false
initial amount: NaN
boundary condition: false
type: Species
name: 4,7,10-hexadecatrienoylcoa
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_d7a35c9f_f813_473d_9d55_867af4219746
name: PNPLA4
initial amount: NaN
is encoded by: hsa:8228
type: Species
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is: P41247

metaR r2111
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110027#
reversible: true
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM udpg r
is: HMDB00286
type: Species
is: CHEBI:58367
boundary condition: false
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
is: SBO:0000247
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaR EX prgstrn LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Progesterone exchange
type: Reaction

metaM peamn c
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
name: 2-phenylethanaminium
is: CHEBI:225237
initial amount: NaN
constant: false
notes: FORMULA: C8H12N CHARGE: 1 INCHI: InChI=1S/C8H11N/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7,9H2/p+1 EHMN_ABBREVIATION: C05332
is: HMDB12275

metaR r2333
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110027#
kinetic law: MODEL1310110027#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
reversible: true

metaR CYTK5
is: SBO:0000176
reactant: MODEL1310110027#
product: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP)
is described by: ECO:0000269
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14

http://identifiers.org/biomodels.db/MODEL1310110027#_3a40da47_db45_4467_a9c1_9efa414a4f84
initial amount: NaN
constant: false
boundary condition: true
name: CHST5
is: Q9GZS9
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:23563
has only substance units: false

metaM sarcs e
initial amount: NaN
constant: false
name: sarcosine
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
is: CHEBI:15611
type: Species
boundary condition: false
is: HMDB00271
has only substance units: false
initial concentration: 1.0

metaR RETNt
type: Reaction
is described by: ECO:0000000
reversible: true
product: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
fast: false
is: SBO:0000185
name: retinoic acid transport
kinetic law: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_1eb7e336_bc27_47a9_83e6_8cbe95bf144e
boundary condition: true
name: RRM2
is: SBO:0000252
is: P31350
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:6241

http://identifiers.org/biomodels.db/MODEL1310110027#_ad11f057_b598_40ca_a398_3baf97b2b764
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
type: Species
name: _J03866_1_m
is encoded by: hsa:J03866

metaR r1773
product: MODEL1310110027#
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
type: Reaction

metaR SUCCt4 2
modifier: MODEL1310110027#
fast: false
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
is: SBO:0000185
reversible: true
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110027#
product: MODEL1310110027#
name: succinate transport via sodium symport

http://identifiers.org/biomodels.db/MODEL1310110027#_39d49120_3909_4dd0_a3ae_04d6335a82a7
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:55350
constant: false
name: VNN3
boundary condition: true
has only substance units: false

metaR HPACtr
is described by: ECO:0000000
kinetic law: MODEL1310110027#
fast: false
type: Reaction
reversible: true
product: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
name: hydroxyphenylacetate transport via diffusion
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110027#_8ec0a4b6_375b_4bb1_92c0_c46b54ebfc65
initial amount: NaN
boundary condition: true
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:X63359
name: _X63359_1_c
is: SBO:0000252
has only substance units: false

metaR r1914
fast: false
reactant: MODEL1310110027#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110027#
is described by: ECO:0000000
modifier: MODEL1310110027#
product: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
is: SBO:0000185

metaR EX ribflv LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Riboflavin
type: Reaction

metaR PROSTGH2t
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
name: Prostaglandin H2 transport
is: SBO:0000185
fast: false
kinetic law: MODEL1310110027#
type: Reaction
reversible: true
is described by: ECO:0000269
product: MODEL1310110027#

metaM gluside hs g
boundary condition: false
name: D-glucosyl-N-acylsphingosine
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
type: Species
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:18368
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_befec373_af37_4497_8d3f_e43126f61a42
type: Species
initial concentration: NaN
initial amount: NaN
name: _AI924226_1_m
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:AI924226
is: SBO:0000252

metaR CYTK9
modifier: MODEL1310110027#
reactant: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
reversible: true
name: cytidylate kinase (CMP,dCTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110027#
fast: false
is: SBO:0000176
product: MODEL1310110027#

metaR RE3626M
kinetic law: MODEL1310110027#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
modifier: MODEL1310110027#
is described by: ECO:0000000
name: RE3626
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110027#
product: MODEL1310110027#

metaM acgam c
boundary condition: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: SBO:0000247
is: CHEBI:17411
constant: false
initial amount: NaN
is: HMDB00215
has only substance units: false
initial concentration: 1.0
type: Species
name: N-acetyl-D-glucosamine

http://identifiers.org/biomodels.db/MODEL1310110027#_93ef3df6_3425_464a_bc3f_007c4db18b8a
is encoded by: hsa:1890
is: P19971
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
name: TYMP
initial amount: NaN
constant: false
initial concentration: NaN

metaR TCYNTtm
name: Thiocyanate transport via diffusion (mitochondrial)
fast: false
product: MODEL1310110027#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM

metaM 3mop m
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: 3-methyl-2-oxopentanoate
initial amount: NaN
is: HMDB00491
boundary condition: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
type: Species
is: CHEBI:28654
constant: false

metaM dgdp n
type: Species
is: CHEBI:58595
initial concentration: 1.0
has only substance units: false
constant: false
name: dGDP(2-)
is: HMDB00960
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_9f27dc65_44d8_4102_8ec6_f8998316976d
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:3906
boundary condition: true
name: LALBA
is: P00709
constant: false
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110027#_58897071_4acd_4ac9_8523_7859139603c7
name: ADH1B
constant: false
is encoded by: hsa:125
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is: P00325
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_8893658e_b702_4af3_bacc_a64aeb6c592e
is: SBO:0000252
is: A7E2E5
is encoded by: hsa:5140
name: PDE3B
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
type: Species

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_56364053_1304_484e_bfaa_79d60166f418
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
type: Species
name: CTPS2
is encoded by: hsa:56474
initial amount: NaN

metaR AG13T4g
modifier: MODEL1310110027#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.4.1.149
reactant: MODEL1310110027#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (10331.1) or (374907.1) or (146712.1) or (374907.2) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
type: Reaction
fast: false
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_7e227ee9_3933_4356_a0b1_50c8c3f9d85e
has only substance units: false
type: Species
constant: false
is: Q4W5N8
initial amount: NaN
name: AADAT
is: SBO:0000252
is encoded by: hsa:51166
initial concentration: NaN
boundary condition: true

metaR r2330
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
kinetic law: MODEL1310110027#
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110027#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

http://identifiers.org/biomodels.db/MODEL1310110027#_1bbdae50_5d2f_4943_8560_383291fb9663
is: P25325
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:4357
initial concentration: NaN
name: MPST
type: Species

metaM 5thf e
constant: false
notes: FORMULA: C39H45N11O18 CHARGE: -6
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB06487
name: pentaglutamyl folate (THF)

http://identifiers.org/biomodels.db/MODEL1310110027#_c8bd41f7_24e4_475f_987d_9884e7551878
initial amount: NaN
has only substance units: false
name: SLC2A9
constant: false
is encoded by: hsa:56606
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110027#_15bdef50_b9ca_4c7a_acfd_7607d8589a93
is: B4DER4
is encoded by: hsa:5291
type: Species
initial concentration: NaN
has only substance units: false
name: PIK3CB
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN

metaM 2dodtricoa m
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB03952
boundary condition: false
constant: false
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
is: C05280
name: 2,6,9-dodecatrienoylcoa

http://identifiers.org/biomodels.db/MODEL1310110027#_7ee2dec8_2c2d_4f7d_bc0d_0e2e9361bebb
constant: false
has only substance units: false
type: Species
is encoded by: hsa:5293
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: PIK3CD
is: A7E2E0

metaR r1915
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110027#
fast: false
reversible: false
name: Y+LAT2 Utilized transport
reactant: MODEL1310110027#
product: MODEL1310110027#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110027#

metaR PA HStn
name: phosphatidate transport, nuclear
is: SBO:0000185
product: MODEL1310110027#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110027#
fast: false
reactant: MODEL1310110027#

metaR CYTK8
fast: false
type: Reaction
modifier: MODEL1310110027#
reversible: true
kinetic law: MODEL1310110027#
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
name: cytidylate kinase (CMP,dATP)
reactant: MODEL1310110027#

metaR ASCBt4
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110027#
reversible: true
fast: false
name: L-ascorbate transport via proton symport
type: Reaction
product: MODEL1310110027#
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#

metaM dgdp m
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB00960
boundary condition: false
has only substance units: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
constant: false
name: dGDP(2-)
is: CHEBI:58595
initial concentration: 1.0

metaR HYXNt
product: MODEL1310110027#
reversible: true
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
modifier: MODEL1310110027#
reactant: MODEL1310110027#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110027#
name: Hypoxanthine transport

metaR ILEt5m
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110027#
is described by: ECO:0000000
reactant: MODEL1310110027#
type: Reaction
name: Isoleucine mitochondrial transport
fast: false
product: MODEL1310110027#

metaM pep m
name: Phosphoenolpyruvate
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
is: C00074
constant: false
is: CHEBI:18021
is: HMDB00263
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
has only substance units: false

metaM ivcoa m
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: Isovaleryl-CoA
constant: false
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939
is: CHEBI:57345
is: HMDB01113
is: SBO:0000247
has only substance units: false

metaR SERGLNNaEx
is: SBO:0000185
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110027#
fast: false
modifier: MODEL1310110027#
is described by: ECO:0000269
reactant: MODEL1310110027#
name: L-serine/L-glutamine Na-dependent exchange (Ser-L in)
reversible: false
type: Reaction
kinetic law: MODEL1310110027#

metaR PI45P4P
reactant: MODEL1310110027#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
product: MODEL1310110027#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110027#
fast: false
name: phosphatidylinositol-4,5-bisphosphate 4-phosphatase

metaR PI4PLCn
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD
is: SBO:0000176
product: MODEL1310110027#
name: phosphatidylinositol 4-phosphate phospholipase C, nucleus
reversible: false
type: Reaction
fast: false
modifier: MODEL1310110027#
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.1.4.11

metaR r2331
kinetic law: MODEL1310110027#
is described by: ECO:0000000
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110027#
fast: false
reactant: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_13229810_e280_48f1_861e_7905501c18b7
is encoded by: hsa:4846
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: A0S0A7
boundary condition: true
has only substance units: false
name: NOS3

metaR FAOXC165C164m
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C16:5-->C16:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_9d24824a_a2d4_4392_a208_f5237641c34d
is: SBO:0000252
is encoded by: hsa:6520
boundary condition: true
name: SLC3A2
initial amount: NaN
is: P08195
constant: false
type: Species
initial concentration: NaN
has only substance units: false

metaM m2emgacpail hs r
has only substance units: false
type: Species
is: http://identifiers.org/pubchem.compound/3380
constant: false
initial amount: NaN
notes: FORMULA: C51H94N2O32P2FULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
name: (dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (H6)
boundary condition: false
is: C00080
is: CHEBI:24636
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_1ea08a21_f197_48b6_877f_8229e1911efd
constant: false
boundary condition: true
name: NDUFB8
is encoded by: hsa:4714
initial concentration: NaN
is: O95169
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaM ac c
has only substance units: false
type: Species
initial amount: NaN
name: acetate
initial concentration: 1.0
is: HMDB00042
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
is: CHEBI:30089

metaM adpcoa x
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB04047
has only substance units: false
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
name: adipoylcoa
initial amount: NaN
is: SBO:0000247
is: C14143

http://identifiers.org/biomodels.db/MODEL1310110027#_544dc803_c8a9_4de5_ae4d_971c3502f2b8
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
type: Species
has only substance units: false
name: CPT1C
is: SBO:0000252
is: Q8TCG5
is encoded by: hsa:126129

metaM ksii core2 pre7 g
constant: false
is: HMDB00175
is: SBO:0000247
is: CHEBI:58053
notes: FORMULA: C67H108N5O51SX CHARGE: -2
is: C00130
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
name: keratan sulfate II biosynthesis, precursor 7

metaR GLUDxm
reversible: true
is version of: http://identifiers.org/ec-code/1.4.1.3
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
kinetic law: MODEL1310110027#
name: glutamate dehydrogenase (NAD) (mitochondrial)
product: MODEL1310110027#
type: Reaction
modifier: MODEL1310110027#
is: SBO:0000176
reactant: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_d2f7fca0_de35_4abc_b0d7_0c2de6ef60e6
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:2544
name: _2544_1_c
boundary condition: true
constant: false
has only substance units: false

metaM sphmyln hs c
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
is: SBO:0000247
name: sphingomyelin betaine
type: Species
constant: false
has only substance units: false
is: CHEBI:58216

http://identifiers.org/biomodels.db/MODEL1310110027#_64943c7f_34dc_4916_a8a6_659d2a3ed0dc
initial concentration: NaN
is encoded by: hsa:1798
name: DPAGT1
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_d0f6726e_0950_4613_b577_e27e6b169951
boundary condition: true
constant: false
is: Q16762
initial concentration: NaN
name: TST
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:7263

metaR EX ksii core4 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 4-linked) exchange
type: Reaction

metaR SO4t4 2
fast: false
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
is: SBO:0000185
reactant: MODEL1310110027#
reversible: true
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
product: MODEL1310110027#
name: sulfate transport via sodium symport

http://identifiers.org/biomodels.db/MODEL1310110027#_e69148c7_fe15_412f_adc0_9914b4cf926f
constant: false
boundary condition: true
initial concentration: NaN
name: SLC16A7
has only substance units: false
is: Q8NEM3
type: Species
is encoded by: hsa:9194
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_05061373_fddc_4e6c_b4ed_cebf4b95c903
is: SBO:0000252
boundary condition: true
name: PIGP
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:51227
constant: false

metaM m6mpdol L r
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:37635
notes: FORMULA: C1660H2728N20O520P20 CHARGE: -20
boundary condition: false
name: (alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog

http://identifiers.org/biomodels.db/MODEL1310110027#_05ff7149_4d53_4d87_a3b9_9097ef46c03a
is encoded by: hsa:79901
name: CYBRD1
is: B4DWD7
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true

metaR APRGSTRNte
is: SBO:0000185
name: hydroxyprogesterone transport
reversible: true
reactant: MODEL1310110027#
fast: false
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110027#

metaR EX lcts LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Lactose exchange
type: Reaction

metaM HC01223 m
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
constant: false
boundary condition: false
is: CHEBI:57340
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
type: Species
initial concentration: 1.0

metaR r0680
reversible: true
reactant: MODEL1310110027#
is: SBO:0000176
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.137
product: MODEL1310110027#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#

metaM thcholstoic m
initial concentration: 1.0
boundary condition: false
is: CHEBI:18402
constant: false
is: HMDB03873
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722

http://identifiers.org/biomodels.db/MODEL1310110027#_8aadf43f_d8db_48bb_83b9_b170505a52c2
constant: false
type: Species
initial amount: NaN
is: Q9Y5P4
boundary condition: true
has only substance units: false
is encoded by: hsa:10087
initial concentration: NaN
name: COL4A3BP
is: SBO:0000252

metaR CHSTEROLtrc
kinetic law: MODEL1310110027#
is: SBO:0000185
reversible: true
is described by: ECO:0000134
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
type: Reaction
reactant: MODEL1310110027#
name: transport of cholesterol into the cytosol
fast: false

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_384ca148_4c19_4fd3_bd81_abc7d2653c03
name: CS
constant: false
initial concentration: NaN
is: SBO:0000252
is: O75390
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:1431

metaR GALNTg
name: GalNAc transferase, Golgi apparatus
is described by: ECO:0000000
fast: false
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.4.1.41
reversible: false
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (26290.1) or (79695.1) or (2589.1) or (50614.1) or (8693.1) or (55568.2) or (114805.1) or (11226.1) or (117248.1) or (11227.1) or (55568.1) or (2590.1) or (51809.1) or (26290.1) or (79623.1) or (63917.1) or (2591.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.41 Confidence Level: 0 AUTHORS: PMID:10767557,PMID:12417297,PMID:12507512,PMID:12634319,PMID:15147861,PMID:9765313 NOTES:NCD
is: SBO:0000176
type: Reaction
modifier: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_88a47783_7b1d_42bf_815e_cdd375064284
is: SBO:0000252
constant: false
name: INPP5J
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:27124
boundary condition: true
initial amount: NaN
is: Q15735

metaR GLYCtm
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110027#
is: SBO:0000185
kinetic law: MODEL1310110027#
fast: false
product: MODEL1310110027#
name: glycerol transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV

http://identifiers.org/biomodels.db/MODEL1310110027#_1bea6b2d_7ec3_4d4e_b62a_11b3879be865
name: PGM3
initial concentration: NaN
type: Species
constant: false
is: B4DX94
boundary condition: true
initial amount: NaN
is encoded by: hsa:5238
is: SBO:0000252
has only substance units: false

metaM paps c
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
is: HMDB01134
is: SBO:0000247
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
initial amount: NaN
is: CHEBI:58339
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
boundary condition: false

metaR H3ETer
is described by: ECO:0000304
fast: false
product: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (23556.1) or (23556.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10574991 NOTES:NCD
is: SBO:0000176
reversible: false
modifier: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#
name: H3 phosphoethanolaminyl transferase, endoplasmic reticulum

metaR r2048
reversible: false
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
modifier: MODEL1310110027#
type: Reaction
fast: false
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#

metaR FAOXC102C103m
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)m
type: Reaction

metaM 5mthf c
constant: false
initial concentration: 1.0
is: HMDB01396
is: C00440
is: SBO:0000247
is: CHEBI:3729
notes: FORMULA: C20H24N7O6 CHARGE: -1
initial amount: NaN
name: 5-Methyltetrahydrofolate
has only substance units: false
type: Species
boundary condition: false

metaR M13N2Tg
fast: false
type: Reaction
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.4.1.101
is: SBO:0000176
reversible: false
is described by: ECO:0000000
name: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
modifier: MODEL1310110027#
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (4245.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.101 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD

metaM n2m2nmasn g
type: Species
is: C04946
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C58H96N5O40X CHARGE: 0
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
has only substance units: false

metaM nad x
has only substance units: false
is: CHEBI:57540
initial concentration: 1.0
initial amount: NaN
name: Nicotinamide adenine dinucleotide
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB00902
constant: false
is: C00003
is: http://identifiers.org/pubchem.compound/3305

metaM adp m
constant: false
is: SBO:0000247
is: HMDB01341
is: C00008
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3310
is: CHEBI:456216
type: Species
name: ADP
initial amount: NaN

metaR r2335
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110027#

metaM pail45p hs c
name: phosphatidylinositol 4,5-bisphosphate
type: Species
initial concentration: 1.0
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:28910
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_a5a9d864_1fdb_4d9a_9dc0_d143f35de488
initial amount: NaN
is: B4DUY1
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:10948
name: STARD3
constant: false

metaR EX HC00822 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chitobiose exchange
type: Reaction

metaM mi1p D n
name: 1D-myo-inositol 1-phosphate(2-)
initial concentration: 1.0
has only substance units: false
is: CHEBI:58433
constant: false
initial amount: NaN
is: HMDB02985
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698

http://identifiers.org/biomodels.db/MODEL1310110027#_f737b90d_300a_4dc9_ab11_4ed67a950660
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
name: _AI694761_1_c
initial concentration: NaN
is encoded by: hsa:AI694761
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_91fca506_b352_4542_8371_397890040f4e
initial concentration: NaN
is: SBO:0000252
name: HMOX1
boundary condition: true
initial amount: NaN
type: Species
is: Q6FH11
constant: false
is encoded by: hsa:3162
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_6d39cb22_6ee2_45e3_9ac3_28a866275215
is encoded by: hsa:1178
initial concentration: NaN
type: Species
constant: false
name: CLC
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: C5HZ13
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_7f028c9b_93d5_416c_94d2_4c9e77579a6b
is encoded by: hsa:2821
is: P06744
boundary condition: true
is: SBO:0000252
name: GPI
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false

metaM tststerone r
initial amount: NaN
name: testosterone
type: Species
has only substance units: false
is: CHEBI:17347
boundary condition: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
is: HMDB00234
is: SBO:0000247
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110027#_fbedb1ea_7580_4319_9125_f83af8f74055
initial concentration: NaN
has only substance units: false
boundary condition: true
name: _H45672_1_m
is encoded by: hsa:H45672
type: Species
initial amount: NaN
is: SBO:0000252
constant: false

metaM acnam c
boundary condition: false
is: HMDB00230
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:35418
name: N-acetylneuraminate
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
type: Species
is: SBO:0000247
initial amount: NaN

metaM ptth c
type: Species
is: CHEBI:16753
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
constant: false
is: SBO:0000247
name: pantetheine
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB03426

metaR BTNt4i
reactant: MODEL1310110027#
reversible: false
modifier: MODEL1310110027#
fast: false
product: MODEL1310110027#
name: Biotin uptake (antiport)
is described by: ECO:0000269
kinetic law: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110027#_0de03a64_e121_4eef_9fed_8c8ec13f0874
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is: P07451
has only substance units: false
boundary condition: true
name: CA3
is: SBO:0000252
is encoded by: hsa:761

metaM adp n
type: Species
is: HMDB01341
boundary condition: false
initial concentration: 1.0
name: ADP(3-)
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:456216

metaR r2334
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
reversible: true
product: MODEL1310110027#
is described by: ECO:0000000
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110027#_349e935f_199f_450a_9cca_048b8ec0802f
boundary condition: true
constant: false
is: O75355
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
name: ENTPD3
initial amount: NaN
is encoded by: hsa:956

metaR THBPT4ACAMDASE
type: Reaction
fast: false
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.96
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110027#_c08e5f06_0a41_4a37_b7bf_0540181ed213
name: FUT8
boundary condition: true
is: A8K8P8
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2530
has only substance units: false
initial concentration: NaN
type: Species

metaR NACHEXA22ly
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110027#
type: Reaction
product: MODEL1310110027#
is described by: ECO:0000000
reactant: MODEL1310110027#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
reversible: false
fast: false
name: beta-N-acetylhexosaminidase A, lysosomal

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

metaR TPI
is described by: ECO:0000134
product: MODEL1310110027#
name: triose-phosphate isomerase
reversible: true
is version of: http://identifiers.org/ec-code/5.3.1.1
fast: false
kinetic law: MODEL1310110027#
is: SBO:0000176
reactant: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
modifier: MODEL1310110027#

metaM glyald c
boundary condition: false
initial amount: NaN
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
is: HMDB01051
has only substance units: false
constant: false
is: C00577
initial concentration: 1.0
is: CHEBI:17378
is: SBO:0000247
name: D-Glyceraldehyde
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_d8cde62c_2067_4869_a93d_9b9ac4e72a6e
name: _AA532636_1_m
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:AA532636
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_ddd338b2_c27f_42df_aa7f_bae3042e4d7d
type: Species
is: SBO:0000252
is encoded by: hsa:4717
initial concentration: NaN
initial amount: NaN
name: NDUFC1
constant: false
boundary condition: true
is: O43677
has only substance units: false

metaM cl c
initial concentration: 1.0
type: Species
is: C00115
is: HMDB00492
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: Cl CHARGE: -1
name: Chloride
is: CHEBI:3966
constant: false

metaM CE4876 r
is: CHEBI:57923
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876
name: delta12-Prostaglandin J2
initial concentration: 1.0

metaM gln L e
name: L-glutamine
boundary condition: false
initial amount: NaN
is: HMDB00641
constant: false
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: CHEBI:18050
initial concentration: 1.0

metaR DNDPt23m
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110027#
is described by: ECO:0000269
type: Reaction
name: dTDP transport via dGTP antiport
modifier: MODEL1310110027#
fast: false
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#

metaR r0755
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (37.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:1898068 NOTES:
is described by: ECO:0000000
fast: false
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
is: SBO:0000176
product: MODEL1310110027#
modifier: MODEL1310110027#
reversible: true
type: Reaction
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5

http://identifiers.org/biomodels.db/MODEL1310110027#_e2145f99_5dac_4cee_8636_abcb290a8630
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:10166
name: SLC25A15
constant: false
is: Q9Y619
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110027#_5a78e4b9_5a1a_48e1_949d_ab91017b0afb
is encoded by: hsa:11227
type: Species
name: GALNT5
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is: A5PKZ1
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_2e726a01_19cd_4439_83a2_ab168cd343d1
is: Q6P1K9
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:80025
boundary condition: true
name: PANK2
type: Species
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_05aa57e3_5af1_43df_b8ca_8083e59b2675
boundary condition: true
has only substance units: false
name: _AD000092_1_c
type: Species
is encoded by: hsa:AD000092
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false

metaR r0321
is: SBO:0000176
product: MODEL1310110027#
kinetic law: MODEL1310110027#
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
is described by: ECO:0000000
modifier: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/6.3.5.2
reactant: MODEL1310110027#
fast: false

metaR r0683
type: Reaction
fast: false
kinetic law: MODEL1310110027#
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
reversible: false
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110027#
is: SBO:0000176
product: MODEL1310110027#

metaR r2119
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
product: MODEL1310110027#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reversible: true
reactant: MODEL1310110027#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000

metaM sphmyln hs g
boundary condition: false
name: sphingomyelin betaine
initial concentration: 1.0
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:58216
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_fdbed01d_ee0d_487f_8bdb_d9f393010916
is encoded by: hsa:84889
name: SLC7A3
is: Q8WY07
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
constant: false

metaM 5mthf e
constant: false
notes: FORMULA: C20H24N7O6 CHARGE: -1
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB01396
initial concentration: 1.0
is: C00440
is: SBO:0000247
is: CHEBI:3729
type: Species
name: 5-Methyltetrahydrofolate

http://identifiers.org/biomodels.db/MODEL1310110027#_847492f4_09c8_45a8_be5e_85c82108ba5f
type: Species
is: B4DR31
is: SBO:0000252
initial amount: NaN
name: DPYSL2
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:1808
initial concentration: NaN

metaR ACNAMtn
type: Reaction
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110027#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: false
name: N-acetylneuraminate nuclear import
kinetic law: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_e5a9033c_1167_49a4_9493_63e698b95147
name: GALNT1
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:2589
is: Q10472

http://identifiers.org/biomodels.db/MODEL1310110027#_91355fdb_7ef2_4641_bf78_3e9642edcc5d
has only substance units: false
name: GALNT4
is: Q8N4A0
is encoded by: hsa:8693
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_5f964976_5fc4_4360_b509_6734da5e5bd7
constant: false
initial concentration: NaN
name: ALDH1A3
is: P47895
boundary condition: true
initial amount: NaN
is encoded by: hsa:220
has only substance units: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_6451018c_48f6_4ce9_9319_8c36bc395ff2
name: NDUFS4
is encoded by: hsa:4724
initial concentration: NaN
is: O43181
boundary condition: true
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

metaR r2196
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110027#
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110027#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110027#
is described by: ECO:0000000

metaR AG13T17g
product: MODEL1310110027#
is: SBO:0000176
reactant: MODEL1310110027#
fast: false
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
reversible: false

metaM pail5p hs c
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
has only substance units: false
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57795
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)

metaM l2n2m2mn l
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB00143
initial concentration: 1.0
name: de-Fuc, reducing GlcNAc removed, de-Sia form of PA6 (w/o peptide linkage)
notes: FORMULA: C54H91N3O41 CHARGE: 0
has only substance units: false
is: CHEBI:12936

metaR EX crm hs LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acylsphingosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_0279bd5a_d92b_4360_afcb_d13de6162d0e
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:6390
initial concentration: NaN
name: SDHB
is: SBO:0000252
type: Species
is: P21912

metaR PNTOte
kinetic law: MODEL1310110027#
type: Reaction
name: Transport of (R)-Pantothenate
is described by: ECO:0000134
reversible: true
reactant: MODEL1310110027#
is: SBO:0000185
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false

metaR r0754
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
reversible: true
type: Reaction
modifier: MODEL1310110027#
is described by: ECO:0000000
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000176
product: MODEL1310110027#
fast: false

metaM dcsptn1crn c
has only substance units: false
initial amount: NaN
is: HMDB06321
constant: false
initial concentration: 1.0
is: SBO:0000247
name: docosa-4,7,10,13,16-pentaenoyl carnitine
type: Species
boundary condition: false
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+

metaR OMPDC
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 4.1.1.23 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
type: Reaction
fast: false
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/2.4.2.10
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
is: SBO:0000176
name: orotidine-5'-phosphate decarboxylase

metaR r1106
kinetic law: MODEL1310110027#
type: Reaction
reactant: MODEL1310110027#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110027#
is: SBO:0000185
fast: false
name: Postulated transport reaction
reversible: true

metaR BHBtm
reversible: true
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
product: MODEL1310110027#
fast: false
is: SBO:0000185
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
kinetic law: MODEL1310110027#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_5eda8885_e1d7_4471_86f7_0756770fb53b
initial amount: NaN
is: P25874
constant: false
has only substance units: false
is encoded by: hsa:7350
is: SBO:0000252
name: UCP1
type: Species
boundary condition: true
initial concentration: NaN

metaM dcacoa x
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:61430
is: SBO:0000247
name: Decanoyl-CoA (n-C10:0CoA)
is: C05274
is: HMDB06404
type: Species

metaR r0531
fast: false
reactant: MODEL1310110027#
name: dUTP:cytidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
is version of: http://identifiers.org/ec-code/1.1.1.34
modifier: MODEL1310110027#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:9923963 NOTES:
reversible: true
is described by: ECO:0000000
product: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#

metaM pail hs n
initial amount: NaN
constant: false
type: Species
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol(1-)
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:57880
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194

metaR ILETA
product: MODEL1310110027#
is described by: ECO:0000269
kinetic law: MODEL1310110027#
name: isoleucine transaminase
type: Reaction
reversible: true
is: SBO:0000176
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.6.1.42
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
fast: false
modifier: MODEL1310110027#

metaR r2118
type: Reaction
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
kinetic law: MODEL1310110027#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110027#
reversible: true
reactant: MODEL1310110027#
modifier: MODEL1310110027#

metaM trdrd c
is: SBO:0000247
has only substance units: false
is: CHEBI:15967
initial amount: NaN
is: C00342
type: Species
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
initial concentration: 1.0
name: Reduced thioredoxin
boundary condition: false
constant: false

metaR GALASE1ly
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
fast: false
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: beta-galactosidase, lysosomal
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4

metaR r2197
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110027#
reversible: true
modifier: MODEL1310110027#
reactant: MODEL1310110027#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110027#
fast: false
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110027#_53532e00_a192_4901_8147_572a01186655
is: Q5SYN6
type: Species
constant: false
has only substance units: false
boundary condition: true
name: SLC22A3
initial amount: NaN
is encoded by: hsa:6581
is: SBO:0000252
initial concentration: NaN

metaM paps g
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
is: HMDB01134
has only substance units: false
is: CHEBI:58339
is: SBO:0000247
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
boundary condition: false
constant: false

metaM gly m
has only substance units: false
type: Species
boundary condition: false
is: HMDB00123
is: C00037
initial concentration: 1.0
name: Glycine
constant: false
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
initial amount: NaN
is: SBO:0000247
is: CHEBI:15428

metaR r1156
is described by: ECO:0000000
reactant: MODEL1310110027#
fast: false
kinetic law: MODEL1310110027#
is: SBO:0000176
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_e4a38c40_c00f_4bb4_a1e0_759cf42b28b6
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:1375
constant: false
is: SBO:0000252
is: E9PCP2
initial amount: NaN
name: CPT1B
initial concentration: NaN

metaM gln L c
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
name: L-glutamine
is: HMDB00641
is: CHEBI:18050
initial concentration: 1.0
constant: false
has only substance units: false

metaM h2o2 e
is: SBO:0000247
name: hydrogen peroxide
initial amount: NaN
is: CHEBI:16240
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
is: HMDB03125
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
has only substance units: false

metaR GPIMTer L
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (93183.1) and (54965.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11226175,PMID:15635094 NOTES:NCD
name: GlcN-acylPI mannosyltransferase, endoplasmic reticulum
fast: false
kinetic law: MODEL1310110027#
is: SBO:0000176
reactant: MODEL1310110027#
type: Reaction
reversible: false
modifier: MODEL1310110027#
product: MODEL1310110027#

metaR RE1897C
name: RE1897
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110027#
reversible: true
fast: false
product: MODEL1310110027#
is: SBO:0000176
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:

metaM g1m8masn r
boundary condition: false
has only substance units: false
is: C05875
initial amount: NaN
initial concentration: 1.0
constant: false
name: (alpha-D-Glucosyl)-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
type: Species
notes: FORMULA: C76H127N2O60X CHARGE: 0
is: SBO:0000247

metaR ALAR
name: alanine racemase
is described by: ECO:0000212
kinetic law: MODEL1310110027#
reversible: true
reactant: MODEL1310110027#
is: SBO:0000176
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (11212.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 5.1.1.1 Confidence Level: 1 AUTHORS: NOTES:
product: MODEL1310110027#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110027#_ff02054f_cf75_4ea0_a31e_30b31caa54e8
name: FH
is: SBO:0000252
is: P07954
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:2271

http://identifiers.org/biomodels.db/MODEL1310110027#_ade558e0_4e8c_46dc_bbf5_52d0ea353ac2
is: SBO:0000252
name: ALG1
initial concentration: NaN
constant: false
is: Q9BT22
boundary condition: true
has only substance units: false
is encoded by: hsa:56052
initial amount: NaN
type: Species

metaR D 3AIBt
product: MODEL1310110027#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
name: D-3-amino-isobutyrate transport
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#

metaR C8DCe
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of suberyl carnitine into the extra cellular space
type: Reaction

metaR INSTt4 2
modifier: MODEL1310110027#
reversible: true
type: Reaction
is: SBO:0000185
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
product: MODEL1310110027#
is described by: ECO:0000006
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD
name: inositol transport via sodium symport
fast: false

http://identifiers.org/biomodels.db/MODEL1310110027#_9bd60fb5_70e7_44a5_82e0_e8bceffe6699
type: Species
has only substance units: false
constant: false
is encoded by: hsa:30
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: ACAA1
is: Q96CA6
initial concentration: NaN

metaR r0267
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.5.1.9
fast: false
reversible: true
is: SBO:0000176
modifier: MODEL1310110027#
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2

http://identifiers.org/biomodels.db/MODEL1310110027#_ce0db2ed_d247_4e8e_a970_f50309bcaab1
initial concentration: NaN
is encoded by: hsa:3098
name: HK1
is: SBO:0000252
boundary condition: true
constant: false
type: Species
is: A8K7J7
initial amount: NaN
has only substance units: false

metaR S6T8g
is: SBO:0000176
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
type: Reaction
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
product: MODEL1310110027#
fast: false

metaR LEUKTRD4t
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110027#
product: MODEL1310110027#
is described by: ECO:0000269
reversible: true
name: leukotriene D4 transport
type: Reaction
fast: false

metaR DNDPt44m
is: SBO:0000185
product: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
fast: false
name: dTTP transport via ATP antiport
modifier: MODEL1310110027#

metaR r2117
modifier: MODEL1310110027#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110027#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
is: SBO:0000185

metaR SERCYSNaEx
name: L-serine/L-cysteine Na-dependent exchange (Ser-L in)
modifier: MODEL1310110027#
reversible: false
reactant: MODEL1310110027#
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110027#
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaM ac e
is: HMDB00042
type: Species
name: acetate
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
initial concentration: 1.0
boundary condition: false
is: CHEBI:30089
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_7a53d67f_cfd1_4f9f_b449_43eaf5349ba2
initial concentration: NaN
is encoded by: hsa:5315
name: PKM2
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_c0f8884b_bc17_43ea_99f0_273b327e33e8
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5289
name: PIK3C3
constant: false
is: Q8NEB9
type: Species
initial amount: NaN

metaR MALSO3tm
is: SBO:0000185
fast: false
reactant: MODEL1310110027#
product: MODEL1310110027#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
name: Malate:sulfite antiport, mitochondrial
kinetic law: MODEL1310110027#
reversible: true

metaR r2198
kinetic law: MODEL1310110027#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
is: SBO:0000185
product: MODEL1310110027#
reversible: true
reactant: MODEL1310110027#
type: Reaction
is described by: ECO:0000000

metaR LEUGLYHYc
is described by: ECO:0000134
kinetic law: MODEL1310110027#
name: hydrolysis of leucylglycine
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: most probable reaction. added during gap filling. NOTES:most probable reaction. added during gap filling.
reversible: true
fast: false
is: SBO:0000176
product: MODEL1310110027#
reactant: MODEL1310110027#

metaM 6htststerone r
name: 6 beta hydroxy testosterone
is: C14497
is: http://identifiers.org/pubchem.compound/17395497
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C19H28O3 CHARGE: 0 INCHI: InChI=1/C19H28O3/c1-18-7-5-11(20)9-15(18)16(21)10-12-13-3-4-17(22)19(13,2)8-6-14(12)18/h9,12-14,16-17,21-22H,3-8,10H2,1-2H3/t12-,13-,14-,16+,17-,18+,19-/m0/s1 EHMN_ABBREVIATION: C14497
has only substance units: false
constant: false
is: HMDB06259
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110027#_e21b613b_e12b_4f17_ba47_54154906fba7
is: SBO:0000252
name: B3GNT8
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:374907

metaR CYSPHELAT2tc
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Cysteine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaR UDPGD
name: UDPglucose 6-dehydrogenase
reversible: false
is described by: ECO:0000304
is: SBO:0000176
modifier: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.1.1.22
fast: false
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (7358.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 1.1.1.22 Confidence Level: 2 AUTHORS: PMID:9296457,PMID:9737970 NOTES:JLR
reactant: MODEL1310110027#

metaR DHPM1
kinetic law: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:
modifier: MODEL1310110027#
is: SBO:0000176
fast: false
reversible: false
reactant: MODEL1310110027#
product: MODEL1310110027#
name: dihydropyrimidinase (5,6-dihydrouracil)
is version of: http://identifiers.org/ec-code/3.5.2.2
is described by: ECO:0000269

metaR r2338
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
product: MODEL1310110027#
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:

metaM CE2417 m
is: SBO:0000247
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
is: CHEBI:28387
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
constant: false
is: HMDB11123

http://identifiers.org/biomodels.db/MODEL1310110027#_301fe5ea_16bd_47b2_b6b1_0f3cfa98fa14
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:5336
name: PLCG2
type: Species
is: P16885
initial concentration: NaN

metaR r0268
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
type: Reaction
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
modifier: MODEL1310110027#
product: MODEL1310110027#
is described by: ECO:0000000
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.1.3.2
kinetic law: MODEL1310110027#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.3.1
fast: false
is: SBO:0000176

metaM orot5p c
is: CHEBI:57538
is: HMDB00218
initial amount: NaN
has only substance units: false
is: C01103
type: Species
name: Orotidine 5'-phosphate
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H10N2O11P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00669 EHMN_ABBREVIATION: C01103

metaR r1318
name: Transport reaction
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
kinetic law: MODEL1310110027#
is: SBO:0000185
reactant: MODEL1310110027#
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110027#

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

metaR r2116
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110027#
is: SBO:0000185
modifier: MODEL1310110027#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110027#_f35b8b76_c2a8_4d75_a6c6_06f5af24b107
initial concentration: NaN
boundary condition: true
constant: false
type: Species
name: HSD17B10
is: Q99714
initial amount: NaN
is encoded by: hsa:3028
is: SBO:0000252
has only substance units: false

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

metaM 6a2ohxnt x
boundary condition: false
constant: false
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-4-2-1-3-5(8)6(9)10/h1-4,7H2,(H,9,10) EHMN_ABBREVIATION: C03239
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: 6-amino-2-oxohexanoic acid
is: HMDB12151
type: Species
is: CHEBI:17534

metaR FUMSO3tm
kinetic law: MODEL1310110027#
type: Reaction
reactant: MODEL1310110027#
fast: false
is: SBO:0000185
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110027#
name: Fumarate:sulfite antiport, mitochondrial

metaR GLCt4
name: glucose transport via sodium symport
type: Reaction
fast: false
product: MODEL1310110027#
reversible: true
modifier: MODEL1310110027#
is: SBO:0000185
reactant: MODEL1310110027#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
kinetic law: MODEL1310110027#

metaM m5mpdol L r
constant: false
initial concentration: 1.0
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:37634
is: SBO:0000247
notes: FORMULA: C1600H2628N20O470P20 CHARGE: -20

metaR ASCBt
kinetic law: MODEL1310110027#
name: L-ascorbate transport via facilitated diffusion
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD
reactant: MODEL1310110027#
is: SBO:0000185
product: MODEL1310110027#
is described by: ECO:0000000

metaR SPH1Pte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
reversible: true
reactant: MODEL1310110027#
name: sph1p transport
type: Reaction
fast: false
product: MODEL1310110027#
is described by: ECO:0000000
kinetic law: MODEL1310110027#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110027#_cff1275a_3cd1_4907_8036_aa3c4dd08ef5
name: CTPS1
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1503
constant: false
initial amount: NaN
is: P17812
boundary condition: true
initial concentration: NaN
type: Species

metaM mgacpail hs r
notes: FORMULA: C37H68NO19PFULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:7896
initial concentration: 1.0
is: HMDB00220
has only substance units: false
name: mannosyl-glucosaminyl-acylphosphatidylinositiol (H2)
initial amount: NaN
is: C00249
constant: false
boundary condition: false
is: SBO:0000247
type: Species

metaM h2o2 c
type: Species
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: C00027
is: CHEBI:16240
constant: false
name: Hydrogen peroxide
is: HMDB03125
has only substance units: false

metaM ddcacoa x
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
is: C01832
is: HMDB03571
is: CHEBI:57375
is: SBO:0000247
name: Dodecanoyl-CoA (n-C12:0CoA)
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

metaR FPGS6m
kinetic law: MODEL1310110027#
product: MODEL1310110027#
name: folylpolyglutamate synthetase (DHF), mitochondrial
is version of: http://identifiers.org/ec-code/6.3.2.17
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT
fast: false
reversible: false
reactant: MODEL1310110027#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction

metaM c6crn e
constant: false
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C13H25NO4 CHARGE: 0
is: HMDB00705
has only substance units: false
name: hexanoyl carnitine
initial concentration: 1.0

metaM gly x
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C2H5NO2 CHARGE: 0 INCHI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
is: HMDB00123
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
name: glycine
is: CHEBI:15428

metaR PMANM
modifier: MODEL1310110027#
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/5.4.2.2
reversible: true
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/5.4.2.8
kinetic law: MODEL1310110027#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:
fast: false
name: phosphomannomutase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_9c2f03a8_b3d3_4b4a_bc0a_06be38e95f74
is encoded by: hsa:4728
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
is: O00217
has only substance units: false
constant: false
name: NDUFS8
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_a9b00fd6_c14f_4e74_a173_6a5017b9de25
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
is: Q9P0J0
name: NDUFA13
initial amount: NaN
is encoded by: hsa:51079

metaR r0156
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
modifier: MODEL1310110027#
is: SBO:0000176
kinetic law: MODEL1310110027#
fast: false
reactant: MODEL1310110027#
product: MODEL1310110027#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.40
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110027#_cccc27f8_2bfd_4b2f_9bf1_77b56bec4314
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaR RE2954C
kinetic law: MODEL1310110027#
name: RE2954
modifier: MODEL1310110027#
is: SBO:0000176
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.1.40
type: Reaction
notes: GENE_ASSOCIATION: (5315.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:10585400,PMID:8967971 NOTES:
fast: false
is described by: ECO:0000000
reversible: true
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_f7a1cbce_a23a_4d0b_b6a3_be3241637f62
has only substance units: false
is encoded by: hsa:2222
is: P37268
name: FDFT1
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species

metaR ADRNCOAtx
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110027#
product: MODEL1310110027#
name: fatty acid intracellular transport
reversible: true
reactant: MODEL1310110027#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

metaM nad r
has only substance units: false
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
constant: false
is: CHEBI:57540
type: Species
name: NAD(1-)
initial amount: NaN
is: SBO:0000247
is: HMDB00902
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110027#_fab492de_2591_454d_a61d_ac712d066fd9
has only substance units: false
boundary condition: true
is: Q14442
is encoded by: hsa:5283
constant: false
is: SBO:0000252
name: PIGH
type: Species
initial amount: NaN
initial concentration: NaN

metaR r2040
kinetic law: MODEL1310110027#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110027#
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110027#
reactant: MODEL1310110027#

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

metaR GLNASNNaEx
reactant: MODEL1310110027#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110027#
name: L-glutamine/L-asparagine Na-dependent exchange (Gln-L in)
reversible: false
is: SBO:0000185
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110027#
fast: false

metaR r1429
type: Reaction
is: SBO:0000185
product: MODEL1310110027#
name: Free diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
reversible: true

metaR r0157
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
kinetic law: MODEL1310110027#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.4.2
reactant: MODEL1310110027#
product: MODEL1310110027#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:

metaR r0688
type: Reaction
kinetic law: MODEL1310110027#
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
fast: false
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110027#
is: SBO:0000176

metaR EX his L LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-histidine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_1f8cd878_8277_4cba_88c2_015ed264d140
type: Species
is: SBO:0000297
name: NME1:NME2
boundary condition: true
is encoded by: hsa:4830
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false

metaM 5adtststerone c
constant: false
initial amount: NaN
is: CHEBI:16330
initial concentration: 1.0
name: 17beta-hydroxy-5alpha-androstan-3-one
has only substance units: false
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
boundary condition: false
is: HMDB02961
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_179d2ab2_7488_4188_aa67_3b45a6da76e7
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:117247
name: SLC16A10
has only substance units: false
boundary condition: true
is: Q8TF71

http://identifiers.org/biomodels.db/MODEL1310110027#_6a7cf178_5488_4920_9311_85db7f1aa90d
initial amount: NaN
has only substance units: false
is: Q86YU0
name: CA7
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:766
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_69b22a89_198c_4a3d_aeb1_a060c9bed7f9
has only substance units: false
initial concentration: NaN
boundary condition: true
name: NDUFA9
is encoded by: hsa:4704
type: Species
is: SBO:0000252
is: Q16795
initial amount: NaN
constant: false

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_ad2d6a6b_8e4c_4eb2_8a1a_6b7f643214eb
is: SBO:0000252
constant: false
is encoded by: hsa:4731
initial amount: NaN
has only substance units: false
type: Species
name: NDUFV3
boundary condition: true
initial concentration: NaN

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_f74171fe_72d2_45aa_9738_57fa7d906934
is: SBO:0000252
is: P21399
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
type: Species
name: ACO1
is encoded by: hsa:48
boundary condition: true

metaR r1109
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
kinetic law: MODEL1310110027#
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110027#_6cfc4ea1_e7dc_4d47_b0a1_940c5d036ac6
name: PRDX3
is encoded by: hsa:10935
constant: false
boundary condition: true
has only substance units: false
is: E9PH29
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species

metaM ksi pre4 g
type: Species
is: C00130
notes: FORMULA: C101H165N7O72X CHARGE: -1
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 4
is: CHEBI:58053
is: HMDB00175

metaM dhap x
type: Species
initial concentration: 1.0
is: CHEBI:57642
boundary condition: false
constant: false
is: HMDB01473
name: Dihydroxyacetone phosphate
is: http://identifiers.org/pubchem.compound/3411
initial amount: NaN
is: C00111
has only substance units: false
is: SBO:0000247

metaR CO2t
reactant: MODEL1310110027#
product: MODEL1310110027#
type: Reaction
name: CO2 transporter via diffusion
reversible: true
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD

metaM HC02121 c
constant: false
type: Species
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180
has only substance units: false
name: S-(hydroxymethyl)glutathione(1-)
is: CHEBI:58758
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaR r1428
name: Free diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
kinetic law: MODEL1310110027#
is described by: ECO:0000000
reactant: MODEL1310110027#
reversible: true
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110027#

metaR O2ter
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
name: O2 transport, endoplasmic reticulum
reversible: true
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110027#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_3de43fcd_5c2a_4b91_8efe_295175e8ba2f
name: _AA278423_1_m
is encoded by: hsa:AA278423
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
constant: false

metaM mlthf m
name: 5,10-Methylenetetrahydrofolate
boundary condition: false
is: C00143
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:15636
initial concentration: 1.0
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
constant: false
is: HMDB01533
type: Species

metaR KSII CORE2tly
is described by: ECO:0000000
reactant: MODEL1310110027#
name: keratan sulfate II (core 2) transport, extracellular to lysosome
is: SBO:0000185
type: Reaction
product: MODEL1310110027#
reversible: false
kinetic law: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110027#_2ca08582_1369_41c7_b1d3_02008a3be598
initial concentration: NaN
name: GAD1
has only substance units: false
is encoded by: hsa:2571
type: Species
initial amount: NaN
is: SBO:0000252
is: Q99259
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_bfd83079_3a78_419c_84c0_59e6a03d6183
constant: false
initial amount: NaN
is encoded by: hsa:NM 001929
name: _NM_001929_1_c
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true

metaR PRAGSr
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.1.2.2
product: MODEL1310110027#
name: phosphoribosylglycinamide synthase
fast: false
reversible: true
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaM HC01162 c
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58376
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
is: SBO:0000247
constant: false
boundary condition: false
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
type: Species

metaR OCT11EFATP
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of vaccenic acid by cells
type: Reaction

metaR EX vitd3 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for calctriol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_4c37e8e6_90c7_4a84_bda1_a0bfca83f95c
is encoded by: hsa:BF195998
name: _BF195998_1_x
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
constant: false
boundary condition: true
initial amount: NaN

metaM h x
name: proton
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
is: C00080
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/3380
is: CHEBI:24636
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_13ef9c33_41a2_4f10_95d1_e90c571732f4
name: PPAP2C
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8612
boundary condition: true
type: Species
is: E9PAY8
constant: false
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_7fc2cf23_f2f8_47e6_9097_633c845a0ef4
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:11238
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
name: CA5B
is: Q9Y2D0

metaM HC02179 c
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:34306
boundary condition: false
name: 20-hydroxy-arachidonate
has only substance units: false
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_f2e2f4a3_a825_4ae9_9de5_d2d4ee142562
boundary condition: true
has only substance units: false
constant: false
name: DPM2
initial amount: NaN
is encoded by: hsa:8818
is: O94777
is: SBO:0000252
initial concentration: NaN
type: Species

metaM ksii core2 deg1 l
is: SBO:0000247
type: Species
notes: FORMULA: C70H113N5O59S3X CHARGE: -3
initial concentration: 1.0
constant: false
is: HMDB00868
boundary condition: false
has only substance units: false
initial amount: NaN
name: keratan sulfate II (core 2-linked), degradation product 1
is: CHEBI:57737

metaR AIRCr
modifier: MODEL1310110027#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.3.2.6
reactant: MODEL1310110027#
reversible: true
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: phosphoribosylaminoimidazole carboxylase
kinetic law: MODEL1310110027#
product: MODEL1310110027#
type: Reaction
fast: false
is: SBO:0000176

metaR MG2er
is described by: ECO:0000000
product: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
kinetic law: MODEL1310110027#
fast: false
is: SBO:0000176
reversible: false
type: Reaction
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum

http://identifiers.org/biomodels.db/MODEL1310110027#_5c6f22b5_ee8e_415d_801c_d012037ccd3e
boundary condition: true
constant: false
has only substance units: false
type: Species
name: SLCO1C1
initial concentration: NaN
is encoded by: hsa:53919
initial amount: NaN
is: SBO:0000252
is: Q5JPA4

metaR S6T15g
type: Reaction
fast: false
kinetic law: MODEL1310110027#
is described by: ECO:0000000
reactant: MODEL1310110027#
modifier: MODEL1310110027#
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.8.2.17
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
is version of: http://identifiers.org/ec-code/2.8.2.21

metaR EX HC02202 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin A1(1-) exchange
type: Reaction

metaM ksii core2 pre10 g
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
name: keratan sulfate II biosynthesis, precursor 10
is: CHEBI:28067
notes: FORMULA: C81H130N6O64S2X CHARGE: -3
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110027#_358e9545_6a81_4582_a741_047fca86fa35
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

metaR SIAT9g
is described by: ECO:0000000
type: Reaction
reversible: false
reactant: MODEL1310110027#
modifier: MODEL1310110027#
product: MODEL1310110027#
is: SBO:0000176
name: Lactosylceramide alpha-2,3-sialyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (8869.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.9 Confidence Level: 4 AUTHORS: PMID:9822625 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.4.99.9
fast: false
kinetic law: MODEL1310110027#

metaR q10tm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000134
name: transport of ubiquinone into mitochondria
kinetic law: MODEL1310110027#
is: SBO:0000185
reactant: MODEL1310110027#
fast: false
reversible: true
type: Reaction
product: MODEL1310110027#

metaR r0686
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.3.2.2
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
is: SBO:0000176
type: Reaction
fast: false
modifier: MODEL1310110027#
reversible: true
is described by: ECO:0000000
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
product: MODEL1310110027#

metaR r0475
is described by: ECO:0000000
product: MODEL1310110027#
kinetic law: MODEL1310110027#
reversible: true
fast: false
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
is: SBO:0000176
reactant: MODEL1310110027#
type: Reaction

metaR ECOAH1m
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
type: Reaction
modifier: MODEL1310110027#
is: SBO:0000176
reversible: true
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
product: MODEL1310110027#
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/4.2.1.18

metaM acgpail hs c
boundary condition: false
initial amount: NaN
name: 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(1-)
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:57265
notes: FORMULA: C17H29NO14PFULLRCO2FULLR2CO2 CHARGE: -1 EHMN_ABBREVIATION: C01288

http://identifiers.org/biomodels.db/MODEL1310110027#_199068fe_2f23_4d79_a3e9_12de5180ce56
type: Species
has only substance units: false
boundary condition: true
name: GALNTL2
initial amount: NaN
is encoded by: hsa:117248
is: SBO:0000252
constant: false
is: Q8N3T1
initial concentration: NaN

metaR r2447
type: Reaction
is: SBO:0000185
name: Concentrative Nucleoside Transporter (CNT) TCDB:2.A.41.2.3
reversible: false
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#

metaM damp c
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB00905
boundary condition: false
is: SBO:0000247
is: CHEBI:58245
type: Species
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
name: dAMP(2-)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_6e588d11_cf80_4c52_949f_27dd9d4bc71e
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: _728226_1_m
is: SBO:0000252
is encoded by: hsa:728226
constant: false

metaM gln L m
initial amount: NaN
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
boundary condition: false
type: Species
has only substance units: false
name: L-glutamine
is: SBO:0000247
is: HMDB00641
constant: false
initial concentration: 1.0
is: CHEBI:18050

metaR EX ksi LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I exchange
type: Reaction

metaR r2043
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
is described by: ECO:0000000
product: MODEL1310110027#
fast: false
modifier: MODEL1310110027#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110027#
is: SBO:0000185
kinetic law: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_c491a6b3_4a9e_421d_8ced_f1043781c2f0
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: Q96SL4
initial amount: NaN
boundary condition: true
type: Species
name: GPX7
is encoded by: hsa:2882

http://identifiers.org/biomodels.db/MODEL1310110027#_0fb198e6_134b_43a2_9efc_e8ab4aa26c98
type: Species
is: Q53TV9
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
name: RPE
initial concentration: NaN
is encoded by: hsa:6120
is: SBO:0000252

metaM HC00361 c
boundary condition: false
name: sedoheptulose 1,7-bisphosphate(4-)
constant: false
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
is: CHEBI:58335
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_1a0bd503_e049_45cb_9100_24866ed0f878
constant: false
initial amount: NaN
is: F8W1L5
type: Species
name: GPD1
is encoded by: hsa:2819
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_d538be7a_368a_4c82_8153_dd3e490ceabc
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:51292
has only substance units: false
type: Species
name: GMPR2
is: Q86T14

metaM 25aics c
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB00797
is: C04823
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
is: CHEBI:58443
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C13H15N4O12P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01356 EHMN_ABBREVIATION: C04823

metaR r0974
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110027#
product: MODEL1310110027#
kinetic law: MODEL1310110027#
name: Active transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
reversible: true
type: Reaction

metaR MAN6PI
reactant: MODEL1310110027#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000304
reversible: true
product: MODEL1310110027#
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/5.3.1.8
type: Reaction
kinetic law: MODEL1310110027#
fast: false
name: mannose-6-phosphate isomerase

http://identifiers.org/biomodels.db/MODEL1310110027#_5bf3b858_b000_406b_bc13_d888f6ec6acf
name: _R06874_1_r
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:R06874
boundary condition: true
constant: false

metaR r0474
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
is: SBO:0000176
reactant: MODEL1310110027#
fast: false
product: MODEL1310110027#
type: Reaction
is described by: ECO:0000000
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
reversible: true
kinetic law: MODEL1310110027#

metaM g2m8mpdol L r
is: C05870
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
has only substance units: false
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
boundary condition: false
notes: FORMULA: C1900H3128N20O720P20 CHARGE: -20
initial concentration: 1.0

metaM pail45p hs m
name: phosphatidylinositol 4,5-bisphosphate
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
type: Species
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:28910

http://identifiers.org/biomodels.db/MODEL1310110027#_6afca3a2_ad8a_4e26_95e7_54be087efd90
has only substance units: false
initial amount: NaN
is: Q9ULD0
name: OGDHL
is: SBO:0000252
is encoded by: hsa:55753
boundary condition: true
constant: false
type: Species
initial concentration: NaN

metaM n2m2nmasn e
notes: FORMULA: C58H96N5O40X CHARGE: 0
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: C04946
type: Species
initial concentration: 1.0
boundary condition: false
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R

metaM 4hexdtetcoa m
initial amount: NaN
name: 4,7,10,13-hexadecatetraenoylcoa
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB02288
constant: false
type: Species

metaR ACCOAgt
type: Reaction
reactant: MODEL1310110027#
product: MODEL1310110027#
fast: false
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12739170 NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ
is: SBO:0000185
reversible: true
is described by: ECO:0000269
name: acetyl-coa transport

metaR r1639
reversible: true
reactant: MODEL1310110027#
modifier: MODEL1310110027#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110027#
product: MODEL1310110027#
is: SBO:0000185

metaR RE2660C
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
name: RE2660
type: Reaction
fast: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110027#
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#

metaM HC02179 e
constant: false
is: CHEBI:34306
name: 20-hydroxy-arachidonate
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748

metaM cl e
notes: FORMULA: Cl CHARGE: -1
has only substance units: false
is: C00115
is: HMDB00492
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:3966
type: Species
name: Chloride

metaM aprgstrn e
is: SBO:0000247
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12-13,16-19,22H,4-11H2,1-3H3/t13-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C04042
has only substance units: false
is: CHEBI:28453
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB03069
name: (20S)-20-hydroxypregn-4-en-3-one
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_02b2e056_81f9_4fcf_8b1d_4bbf6f5be286
is: P05062
has only substance units: false
initial concentration: NaN
is encoded by: hsa:229
initial amount: NaN
constant: false
name: ALDOB
boundary condition: true
is: SBO:0000252
type: Species

metaR RETt
fast: false
name: Retinol transport via faciliated diffusion
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reactant: MODEL1310110027#
is described by: ECO:0000000
kinetic law: MODEL1310110027#
type: Reaction
reversible: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110027#_115ba59b_745a_4585_a80c_e661b1e6f3cb
name: SLC34A2
is: O95436
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:10568
initial concentration: NaN
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_a5fdf01f_6cd2_4863_9da3_3a3eeac96ab0
has only substance units: false
is: SBO:0000252
is: P49189
constant: false
is encoded by: hsa:223
type: Species
initial concentration: NaN
initial amount: NaN
name: ALDH9A1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110027#_8fd0d72a_5ee9_48c2_a8ba_1fee6ce26e38
initial concentration: NaN
name: GCK
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:2645
initial amount: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110027#_8a90ba2e_13a4_4aa2_82a7_cac8252e78ee
initial concentration: NaN
is encoded by: hsa:9583
is: Q9Y227
is: SBO:0000252
boundary condition: true
name: ENTPD4
has only substance units: false
initial amount: NaN
type: Species
constant: false

metaM hco3 e
has only substance units: false
boundary condition: false
initial amount: NaN
is: C00288
constant: false
type: Species
is: CHEBI:17544
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
initial concentration: 1.0
name: Bicarbonate
is: SBO:0000247
is: HMDB00595

http://identifiers.org/biomodels.db/MODEL1310110027#_60d5ced2_0fb0_455b_bcae_633a6ee1e0bc
is encoded by: hsa:27124
initial concentration: NaN
type: Species
constant: false
has only substance units: false
name: INPP5J
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaR TSULt4 3
is described by: ECO:0000269
product: MODEL1310110027#
modifier: MODEL1310110027#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6561.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10811962,PMID:11161786 NOTES:NCD
type: Reaction
reactant: MODEL1310110027#
reversible: true
kinetic law: MODEL1310110027#
fast: false
name: thiosulfate transport via sodium symport

metaM pail45p hs n
boundary condition: false
is: CHEBI:28910
type: Species
constant: false
name: phosphatidylinositol 4,5-bisphosphate
initial concentration: 1.0
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaM ahcys c
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
constant: false
is: C00021
name: S-Adenosyl-L-homocysteine
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB00939
is: CHEBI:16680

metaR IZPN
kinetic law: MODEL1310110027#
product: MODEL1310110027#
fast: false
reactant: MODEL1310110027#
reversible: false
name: Imidazolonepropionase
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR RE1523M
is described by: ECO:0000000
modifier: MODEL1310110027#
name: RE1523
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
is: SBO:0000176
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
product: MODEL1310110027#

metaR EX oagd3 hs LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 9-O-Acetylated GD3 (homo sapiens) exchange
type: Reaction

metaM ddcacoa m
is: HMDB03571
is: SBO:0000247
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
type: Species
constant: false
is: C01832
boundary condition: false
initial concentration: 1.0
is: CHEBI:57375
name: Dodecanoyl-CoA (n-C12:0CoA)
has only substance units: false
initial amount: NaN

metaR RE2972M
fast: false
modifier: MODEL1310110027#
is described by: ECO:0000000
is: SBO:0000176
reversible: true
type: Reaction
product: MODEL1310110027#
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.1.67
reactant: MODEL1310110027#
name: RE2972
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:

metaR GPDDA1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.46 Confidence Level: 0 AUTHORS: NOTES:JLR
reactant: MODEL1310110027#
reversible: false
kinetic law: MODEL1310110027#
is: SBO:0000176
is described by: ECO:0000000
name: Glycerophosphodiester phosphodiesterase (Glycerophosphocholine)
fast: false
product: MODEL1310110027#

metaM ac m
is: SBO:0000247
name: acetate
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
is: HMDB00042
is: CHEBI:30089
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
type: Species
boundary condition: false

metaR r1638
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110027#
is: SBO:0000185
kinetic law: MODEL1310110027#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110027#
modifier: MODEL1310110027#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM 13 cis retn r
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB06219
constant: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/7847414
is: D00348
initial amount: NaN
name: 13-cis-retinoate
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952

metaR G14T4g
is: SBO:0000176
modifier: MODEL1310110027#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22

http://identifiers.org/biomodels.db/MODEL1310110027#_17f2631b_93a7_4b1c_bf91_db585283843d
is encoded by: hsa:8790
constant: false
is: SBO:0000252
name: FPGT
boundary condition: true
is: O14772
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_bc080817_889b_4d85_b542_a7c8f652cc1f
is encoded by: hsa:125206
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
name: SLC5A10
boundary condition: true
is: A0PJK1
has only substance units: false

metaM adrncoa x
name: adrenyl coenzyme A
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205480
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
initial amount: NaN
constant: false
is: C16170
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR RE0926E
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
name: RE0926
is version of: http://identifiers.org/ec-code/3.2.1.17
is version of: http://identifiers.org/ec-code/3.2.1.1
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110027#
product: MODEL1310110027#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110027#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110027#_b7d5989f_eea9_4220_befd_913c19608969
boundary condition: true
is: Q53XN1
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:1351
constant: false
name: COX8A
has only substance units: false
initial amount: NaN

metaR r0472
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reactant: MODEL1310110027#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
kinetic law: MODEL1310110027#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110027#
fast: false

metaR ACACt2m
modifier: MODEL1310110027#
product: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
is described by: ECO:0000269
kinetic law: MODEL1310110027#
name: Acetoacetate mitochondrial transport via H+ symport
is: SBO:0000185
reversible: true
reactant: MODEL1310110027#
fast: false

metaM glyc3p c
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: CHEBI:57597
is: HMDB00126
constant: false
type: Species
is: C00093
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: Glycerol 3-phosphate
boundary condition: false
is: SBO:0000247

metaR UAG4E
type: Reaction
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000304
fast: false
name: UDP-N-acetylglucosamine 4-epimerase
product: MODEL1310110027#
is: SBO:0000176
modifier: MODEL1310110027#
reversible: true
is version of: http://identifiers.org/ec-code/5.1.3.2

metaR NDPK7n
kinetic law: MODEL1310110027#
fast: false
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
type: Reaction
is described by: ECO:0000304
modifier: MODEL1310110027#
product: MODEL1310110027#

metaM h2o2 m
boundary condition: false
name: Hydrogen peroxide
is: HMDB03125
constant: false
is: SBO:0000247
type: Species
is: CHEBI:16240
has only substance units: false
is: C00027
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
initial amount: NaN
initial concentration: 1.0

metaM pail hs c
name: 1-phosphatidyl-1D-myo-inositol(1-)
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:57880
has only substance units: false
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
initial concentration: 1.0

metaR GLXtp
name: glyoxylate transport, peroxisomal
kinetic law: MODEL1310110027#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
reactant: MODEL1310110027#
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110027#
type: Reaction

metaM udpg c
boundary condition: false
is: HMDB00286
is: CHEBI:58367
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
initial amount: NaN
is: C00029
name: UDPglucose
initial concentration: 1.0
type: Species

metaR OCD11CRNCACT
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaR r1637
modifier: MODEL1310110027#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
product: MODEL1310110027#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

metaM aprgstrn c
boundary condition: false
is: CHEBI:28453
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
name: (20S)-20-hydroxypregn-4-en-3-one
is: HMDB03069
type: Species
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12-13,16-19,22H,4-11H2,1-3H3/t13-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C04042

metaR RE3005M
is: SBO:0000176
product: MODEL1310110027#
name: RE3005
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
type: Reaction
modifier: MODEL1310110027#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110027#_51649110_3810_4b54_9f1a_222be3dec8f2
is: SBO:0000252
constant: false
is: Q9BXI2
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:83884
boundary condition: true
initial amount: NaN
name: SLC25A2

metaR r2443
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110027#
reversible: false
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
is described by: ECO:0000000
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_a488a22f_c1b6_4d3f_8ede_40d388b3c5f1
is: SBO:0000252
constant: false
type: Species
boundary condition: true
name: DHFR
is: P00374
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1719
has only substance units: false

metaM hco3 c
boundary condition: false
is: HMDB00595
is: C00288
type: Species
is: CHEBI:17544
initial amount: NaN
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
constant: false
initial concentration: 1.0
name: Bicarbonate
is: SBO:0000247
has only substance units: false

metaR PCm
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
reversible: false
notes: GENE_ASSOCIATION: (5091.1) or (5091.2) SUBSYSTEM: Pyruvate metabolism EC Number: 6.4.1.1 Confidence Level: 4 AUTHORS: PMID:6548474 NOTES:TV Metabolism at a glance
product: MODEL1310110027#
type: Reaction
is version of: http://identifiers.org/ec-code/6.4.1.1
is: SBO:0000176
is described by: ECO:0000269
fast: false
name: pyruvate carboxylase

metaM nh4 x
is: CHEBI:28938
initial amount: NaN
is: SBO:0000247
is: HMDB00051
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: Ammonium
type: Species
constant: false
is: C01342

metaR r0973
name: Facilitated diffusion
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
type: Reaction
is described by: ECO:0000000

metaM nad m
name: Nicotinamide adenine dinucleotide
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/3305
is: C00003
is: SBO:0000247
is: HMDB00902
boundary condition: false
is: CHEBI:57540

http://identifiers.org/biomodels.db/MODEL1310110027#_9aeff76a_368e_43cb_be2a_d703a632873a
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:27068
initial concentration: NaN
is: SBO:0000252
type: Species
name: PPA2
is: F8WDN9

metaR PROD2m
is described by: ECO:0000254
is: SBO:0000176
modifier: MODEL1310110027#
name: Proline dehydrogenase (m)
reversible: false
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.5.99.8
type: Reaction
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR SAB m
product: MODEL1310110027#
fast: false
kinetic law: MODEL1310110027#

metaR LEUtec
type: Reaction
reactant: MODEL1310110027#
is: SBO:0000185
modifier: MODEL1310110027#
is described by: ECO:0000269
name: L-leucine transport via diffusion (extracellular to cytosol)
product: MODEL1310110027#
reversible: true
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
fast: false
kinetic law: MODEL1310110027#

metaR r1423
fast: false
name: Facilitated diffusion
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
type: Reaction
is described by: ECO:0000000
reversible: false
is: SBO:0000185

metaR DESAT18 3
type: Reaction
product: MODEL1310110027#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
fast: false
is version of: http://identifiers.org/ec-code/1.14.19.1
kinetic law: MODEL1310110027#
reversible: false
name: stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)
is: SBO:0000176
reactant: MODEL1310110027#
modifier: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_087e5bb4_a23b_4851_b05f_8357ec0276fa
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:18
initial concentration: NaN
type: Species
name: ABAT
has only substance units: false
initial amount: NaN

metaM gar c
initial concentration: 1.0
is: C03838
is: HMDB02022
notes: FORMULA: C7H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01190 EHMN_ABBREVIATION: C03838
boundary condition: false
name: N1-(5-Phospho-D-ribosyl)glycinamide
is: CHEBI:58457
constant: false
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaR r0512
fast: false
reversible: true
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
modifier: MODEL1310110027#
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.17.4.1
type: Reaction
is described by: ECO:0000000
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110027#_5e08e57d_369a_4972_9a1c_ae723bfe68d6
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:AI631997
initial amount: NaN
is: SBO:0000252
name: _AI631997_1_m
type: Species

metaM udpglcur c
constant: false
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:58052
name: UDP-D-glucuronate
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
is: HMDB00935
is: SBO:0000247
has only substance units: false
is: C00167
initial concentration: 1.0

metaR VALtec
type: Reaction
reversible: true
reactant: MODEL1310110027#
modifier: MODEL1310110027#
is described by: ECO:0000269
name: L-valine transport via diffusion (extracellular to cytosol)
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
kinetic law: MODEL1310110027#
is: SBO:0000185
fast: false

metaM dhlam m
type: Species
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
boundary condition: false
name: dihydrolipoamide
is: CHEBI:17694
is: HMDB00985
initial amount: NaN

metaR GGH 6DHFe
name: Gamma-glutamyl hydrolase (6DHF), extracellular
is: SBO:0000176
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
modifier: MODEL1310110027#
fast: false
is version of: http://identifiers.org/ec-code/3.4.19.9
reversible: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
product: MODEL1310110027#

metaM cmp g
boundary condition: false
is: CHEBI:60377
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
name: CMP(2-)
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: SBO:0000247
is: HMDB00095
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_ed650ca0_511a_4a04_a4c3_dee4a099e91b
type: Species
is encoded by: hsa:2650
has only substance units: false
initial amount: NaN
is: Q02742
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: GCNT1

metaM CE0693 m
constant: false
is: SBO:0000247
is: CHEBI:28387
name: 3-oxolaur-6-cis-enoyl-CoA
type: Species
initial amount: NaN
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
is: HMDB11123
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaM HC00250 c
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
name: hydrosulfide
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: CHEBI:29919
is: SBO:0000247

metaR ACACT10m
modifier: MODEL1310110027#
reversible: true
type: Reaction
is described by: ECO:0000134
product: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
kinetic law: MODEL1310110027#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.9
is: SBO:0000176
name: acetyl-CoA C-acetyltransferase, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110027#_5a6c534f_f4a9_417c_a357_24bd9a9f09ef
boundary condition: true
initial amount: NaN
type: Species
name: GGT2
is encoded by: hsa:728441
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_8e0808de_a8b2_484b_b834_bf8cd85e6b3d
type: Species
name: ESPN
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:83715
is: B1AK53
boundary condition: true
initial concentration: NaN

metaR DSAT
name: dihydrosphingosine N-acyltransferase
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ
product: MODEL1310110027#
is described by: ECO:0000000
reactant: MODEL1310110027#
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110027#
reversible: false

metaM HC02187 e
is: SBO:0000247
constant: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: reverse-triiodthyronine
type: Species
is: CHEBI:28774
has only substance units: false

metaM ksi pre10 g
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C129H209N9O98S2X CHARGE: -3
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:58053
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 10
is: C00130

metaM dha e
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
constant: false
is: SBO:0000247
is: CHEBI:16016
has only substance units: false
name: glycerone
is: HMDB01882
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_aa034f75_2db0_4b1e_88ef_7d16d0874a3d
is: O14734
initial amount: NaN
boundary condition: true
is encoded by: hsa:10005
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
name: ACOT8
constant: false

metaM acnam n
is: HMDB00230
name: N-acetylneuraminate
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:35418
type: Species
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
initial amount: NaN
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110027#_68eca6a0_bd7e_4246_8de3_4d78bcba7e73
constant: false
name: AOC2
is: SBO:0000252
type: Species
is encoded by: hsa:314
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN

metaR r0726
product: MODEL1310110027#
fast: false
is: SBO:0000176
modifier: MODEL1310110027#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.33
type: Reaction
reactant: MODEL1310110027#
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
kinetic law: MODEL1310110027#
reversible: true

metaR EX ksii core2 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 2-linked) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_630b20d8_1313_4192_a592_0b3f243264f0
type: Species
initial amount: NaN
constant: false
boundary condition: true
is: O75912
name: DGKI
initial concentration: NaN
has only substance units: false
is encoded by: hsa:9162
is: SBO:0000252

metaR r1617
reversible: true
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110027#
type: Reaction
product: MODEL1310110027#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR NCNt
name: Na+/Ca2+-NH4+ exchange
reversible: true
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
reactant: MODEL1310110027#
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
fast: false
product: MODEL1310110027#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_b40d7d9d_191c_401d_a42d_b5474df69ac3
type: Species
is encoded by: hsa:3284
constant: false
initial concentration: NaN
name: HSD3B2
is: P26439
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_583b323e_c122_4617_a3cc_061c52ae6ecf
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AI222095
name: _AI222095_1_m
type: Species
has only substance units: false
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_c7ede282_1a1e_4b15_b6e4_40748bd3fe9b
boundary condition: true
is: SBO:0000252
type: Species
name: ADSL
constant: false
initial concentration: NaN
initial amount: NaN
is: P30566
is encoded by: hsa:158
has only substance units: false

metaR r0596
reactant: MODEL1310110027#
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
modifier: MODEL1310110027#
type: Reaction
is: SBO:0000176
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110027#
fast: false
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4

metaM ins c
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
is: C00294
boundary condition: false
is: CHEBI:17596
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB00195
initial concentration: 1.0
name: Inosine
type: Species

metaR SRTNtu
is described by: ECO:0000269
reversible: true
type: Reaction
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (6580.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
is: SBO:0000185
fast: false
kinetic law: MODEL1310110027#
name: Serotonin uniport
reactant: MODEL1310110027#
product: MODEL1310110027#

metaM prostge2 e
boundary condition: false
is: HMDB01220
name: prostaglandin E2(1-)
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:606564
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584

metaM CE2431 m
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:57795
initial concentration: 1.0
boundary condition: false
name: cis-deca-4-enoyl-CoA
type: Species
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
constant: false

metaR Uritn
reactant: MODEL1310110027#
fast: false
kinetic law: MODEL1310110027#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185
product: MODEL1310110027#
name: uridine transport in nucleus
type: Reaction

metaR UDPtl
type: Reaction
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ
reversible: true
is described by: ECO:0000000
fast: false
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
name: udp intracellular transport
is: SBO:0000185

metaM HC02205 e
constant: false
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
is: CHEBI:28099
is: SBO:0000247
name: prostaglandin-b2
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false

metaM m1mpdol L c
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:28067
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C1360H2228N20O270P20 CHARGE: -20 INCHI: InChI=1S/C53H92N2O27P2/c1-27(2)13-9-14-28(3)15-10-16-29(4)17-11-18-30(5)19-12-20-31(6)21-22-73-83(69,70)82-84(71,72)81-51-39(55-33(8)61)43(65)47(37(26-59)77-51)78-50-38(54-32(7)60)42(64)48(36(25-58)76-50)79-53-46(68)49(41(63)35(24-57)75-53)80-52-45(67)44(66)40(62)34(23-56)74-52/h13,15,17,19,31,34-53,56-59,62-68H,9-12,14,16,18,20-26H2,1-8H3,(H,54,60)(H,55,61)(H,69,70)(H,71,72)/b28-15+,29-17+,30-19+/t31?,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47-,48-,49+,50+,51-,52-,53+/m1/s1
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human liver homolog
type: Species
constant: false

metaR GK1
fast: false
product: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: guanylate kinase (GMP:ATP)
kinetic law: MODEL1310110027#
reversible: true
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.4.8
type: Reaction
is: SBO:0000176
is described by: ECO:0000269

metaR PPAm
is version of: http://identifiers.org/ec-code/3.6.1.1
modifier: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
is described by: ECO:0000269
fast: false
type: Reaction
product: MODEL1310110027#
kinetic law: MODEL1310110027#
name: inorganic diphosphatase
is: SBO:0000176
reversible: false

metaR RE0512M
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
name: RE0512
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.107

metaM gltcho e
is: C08277
has only substance units: false
name: beta glucan-taurocholic acid complex
type: Species
notes: FORMULA: C1200026H2200045NO1100007S CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB00792
constant: false

metaR G14T3g
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110027#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
type: Reaction
is: SBO:0000176
modifier: MODEL1310110027#
product: MODEL1310110027#
is described by: ECO:0000000
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.22

metaR r1618
modifier: MODEL1310110027#
reactant: MODEL1310110027#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110027#
is: SBO:0000185
fast: false
product: MODEL1310110027#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_312dc1b9_a486_4667_958f_4fae8f535d08
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
is: P30038
is encoded by: hsa:8659
boundary condition: true
initial concentration: NaN
name: ALDH4A1
type: Species

metaR SPHMYLNtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
is: SBO:0000185
product: MODEL1310110027#
fast: false
reversible: true
name: sphingomyelin intracellular transport

metaM occoa m
constant: false
is: C01944
name: Octanoyl-CoA (n-C8:0CoA)
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:57386
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01070

metaM pe hs e
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:16038
boundary condition: false
has only substance units: false
name: phosphatidylethanolamine
is: SBO:0000247
constant: false

metaM HC00250 e
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
initial concentration: 1.0
is: CHEBI:29919
name: hydrosulfide
boundary condition: false
constant: false
type: Species

metaR CYTK3n
modifier: MODEL1310110027#
reactant: MODEL1310110027#
type: Reaction
reversible: true
is described by: ECO:0000269
name: cytidylate kinase (dCMP,CTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110027#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM 56dura c
name: 5,6-dihydrouracil
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:15901
is: HMDB00076
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_3dccb1a9_cb17_4f93_b6d5_3290425687cd
type: Species
name: ST20
boundary condition: true
is: Q9HBF5
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:400410
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110027#_cbc2d933_8ecf_4170_9384_9094b1a1a766
is: SBO:0000252
boundary condition: true
is: P00439
name: PAH
initial amount: NaN
is encoded by: hsa:5053
initial concentration: NaN
constant: false
type: Species
has only substance units: false

metaR r1970
is described by: ECO:0000000
modifier: MODEL1310110027#
reactant: MODEL1310110027#
reversible: false
is: SBO:0000185
fast: false
product: MODEL1310110027#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110027#

metaR DNDPt27m
reactant: MODEL1310110027#
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
name: dCDP transport via dTDP antiport
type: Reaction
product: MODEL1310110027#
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_c6152ada_9abd_4748_8ab5_78a3ba4de6e8
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:8503
is: SBO:0000297
initial amount: NaN
has only substance units: false
type: Species
has part: A7E2E0
name: PIK3CD:PIK3R3
is encoded by: hsa:5293
has part: Q92569

http://identifiers.org/biomodels.db/MODEL1310110027#_71cfdae5_8661_4fe5_8cc4_82691a3d569d
is encoded by: hsa:2530
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is: B4DFS7
name: FUT8
type: Species

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

metaM hmgcoa x
is: CHEBI:15467
constant: false
boundary condition: false
is: SBO:0000247
name: Hydroxymethylglutaryl-CoA
initial amount: NaN
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
has only substance units: false
is: HMDB01375
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_c7454925_223f_4231_851d_48316465feb8
is: Q8TF08
type: Species
boundary condition: true
initial amount: NaN
name: COX7B2
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:170712
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_6c95e0b5_ff3d_4b07_a707_aedf36e12919
is: SBO:0000252
name: PGM1
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
is: B4DPV0
is encoded by: hsa:5236
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110027#_ed4c732a_f288_4e19_b361_791b2ae1393f
initial amount: NaN
constant: false
is encoded by: hsa:5331
boundary condition: true
initial concentration: NaN
type: Species
name: PLCB3
is: SBO:0000252
has only substance units: false
is: G5E960

http://identifiers.org/biomodels.db/MODEL1310110027#_4e2fc07b_0181_422c_8063_47ded78ef414
is: B2R6S5
initial concentration: NaN
initial amount: NaN
name: CMPK1
boundary condition: true
type: Species
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:51727

metaM HC01408 m
is: SBO:0000247
initial concentration: 1.0
name: 3-Oxohexanoyl-CoA
is: CHEBI:27648
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
type: Species

metaR PPAn
reactant: MODEL1310110027#
reversible: false
type: Reaction
product: MODEL1310110027#
is: SBO:0000176
kinetic law: MODEL1310110027#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: 3.6.1.1 Confidence Level: 1 AUTHORS: NOTES:
name: inorganic diphosphatase, nuclear
fast: false

metaM fmn c
has only substance units: false
is: C00061
type: Species
initial amount: NaN
initial concentration: 1.0
name: FMN
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB01520
is: CHEBI:58210

http://identifiers.org/biomodels.db/MODEL1310110027#_f1a7fcdc_55cf_487a_b289_29e8a741d172
constant: false
has only substance units: false
is: A8K003
is: SBO:0000252
is encoded by: hsa:5372
name: PMM1
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN

metaM HC02187 c
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
name: reverse-triiodthyronine
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:28774

metaR r0728
is described by: ECO:0000000
kinetic law: MODEL1310110027#
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reversible: true
reactant: MODEL1310110027#
product: MODEL1310110027#
is: SBO:0000176

metaR r0514
name: Dihydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:4396284,PMID:6882460,PMID:962851 NOTES:
product: MODEL1310110027#
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#

metaR S6TASE25ly
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
type: Reaction
modifier: MODEL1310110027#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: galactose-6-sulfate sulfatase, lysosomal
reactant: MODEL1310110027#
product: MODEL1310110027#

metaR EX chtn LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chitin exchange
type: Reaction

metaR r1619
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
product: MODEL1310110027#
is described by: ECO:0000000
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
reactant: MODEL1310110027#

metaR PIter
is: SBO:0000185
reactant: MODEL1310110027#
product: MODEL1310110027#
reversible: true
is described by: ECO:0000212
fast: false
type: Reaction
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
name: phosphate transport, endoplasmic reticulum
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD

metaM acnam l
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
name: N-acetylneuraminate
has only substance units: false
boundary condition: false
is: HMDB00230
initial concentration: 1.0
is: CHEBI:35418
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270

metaR NRPPHRSULT
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.8.2.1
modifier: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000269
fast: false
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (6818.1) or (6818.3) or (6818.2) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
name: Norepinephrine Sulfotransferase
reversible: false
kinetic law: MODEL1310110027#
type: Reaction

metaM prostge2 c
is: CHEBI:606564
is: SBO:0000247
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
initial concentration: 1.0
boundary condition: false
constant: false
name: prostaglandin E2(1-)
is: HMDB01220
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_08c16f8c_17ca_4170_aa51_59850768eb77
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: P35218
type: Species
has only substance units: false
is encoded by: hsa:763
constant: false
name: CA5A
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_8570028d_f5ca_4429_bd02_41b55444c6d7
is: SBO:0000252
has only substance units: false
is: Q8N1Q1
is encoded by: hsa:377677
constant: false
boundary condition: true
name: CA13
initial amount: NaN
initial concentration: NaN
type: Species

metaM HC02205 c
has only substance units: false
type: Species
boundary condition: false
name: prostaglandin-b2
is: CHEBI:28099
initial amount: NaN
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
initial concentration: 1.0
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_a49c7322_325a_4220_99d6_d28c68336fac
has only substance units: false
is: Q08828
is encoded by: hsa:107
boundary condition: true
name: ADCY1
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_131694f6_ad57_4e87_aa37_fabc4f2538dd
is: SBO:0000252
name: ACO1
initial amount: NaN
is: P21399
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
constant: false
is encoded by: hsa:48

metaR r0181
is version of: http://identifiers.org/ec-code/1.2.1.3
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
is described by: ECO:0000000
product: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
modifier: MODEL1310110027#
reversible: true
reactant: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_d679ee85_99dc_4b1a_a817_dc4a0af71565
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:26275
boundary condition: true
name: HIBCH
is: Q6NVY1
type: Species

metaR GTHPm
fast: false
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.11.1.15
product: MODEL1310110027#
is described by: ECO:0000269
reversible: true
name: glutathione peroxidase, mitochondria
is version of: http://identifiers.org/ec-code/1.11.1.12

metaM xan c
initial concentration: 1.0
initial amount: NaN
is: HMDB00292
is: SBO:0000247
type: Species
constant: false
name: Xanthine
is: C00385
boundary condition: false
is: CHEBI:17712
has only substance units: false
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385

http://identifiers.org/biomodels.db/MODEL1310110027#_c24f8534_e6e0_4dfc_93d6_41f672c71959
is encoded by: hsa:4716
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
is: A8K761
boundary condition: true
has only substance units: false
name: NDUFB10

http://identifiers.org/biomodels.db/MODEL1310110027#_11e2acd6_0988_4f74_87bf_103234e219bc
initial amount: NaN
has only substance units: false
name: GSR
is: SBO:0000252
boundary condition: true
is: P00390
type: Species
initial concentration: NaN
is encoded by: hsa:2936
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_4d18c83e_2ac8_497a_a874_3d55228ca4d6
is encoded by: hsa:2618
name: GART
is: Q59HH3
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_ad7f954d_ec11_40af_9abf_cff92250fb1a
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4842
has only substance units: false
constant: false
name: NOS1
boundary condition: true
type: Species
is: SBO:0000252
is: B4DG68

metaM Rtotal e
initial concentration: 1.0
is: CHEBI:3554
notes: FORMULA: CO2FULLR CHARGE: -1
boundary condition: false
constant: false
is: HMDB00244
type: Species
is: SBO:0000247
has only substance units: false
is: C00255
name: R total
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_b06b7f29_4125_4cdd_963c_d3953fb652ad
has only substance units: false
boundary condition: true
initial amount: NaN
is: Q9Y259
type: Species
initial concentration: NaN
is encoded by: hsa:1120
is: SBO:0000252
name: CHKB
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_7b42223b_0d06_4f57_8bea_3c324e2af8c6
initial amount: NaN
boundary condition: true
has only substance units: false
name: HK1
constant: false
is: SBO:0000252
is encoded by: hsa:3098
type: Species
is: P19367
initial concentration: NaN

metaR GLYSARCNc
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Hydrolysis of glycylsarcosine for uptake
type: Reaction

metaR UDPDOLPT L
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:8280060 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (liver)
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.4.1.117
product: MODEL1310110027#
reversible: false

metaR G14T11g
reversible: false
is: SBO:0000176
modifier: MODEL1310110027#
product: MODEL1310110027#
kinetic law: MODEL1310110027#
fast: false
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is described by: ECO:0000000

metaM pe hs c
initial concentration: 1.0
name: phosphatidylethanolamine
is: SBO:0000247
type: Species
is: CHEBI:16038
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0

metaR r1613
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110027#
is: SBO:0000185
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110027#
is described by: ECO:0000000
product: MODEL1310110027#

metaM trp L e
type: Species
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
is: CHEBI:16828
initial amount: NaN
is: HMDB00929
initial concentration: 1.0
name: L-tryptophan

metaR r1569
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
fast: false
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110027#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM nadp r
is: C00006
boundary condition: false
is: SBO:0000247
is: CHEBI:58349
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
initial amount: NaN
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide phosphate
constant: false
has only substance units: false
type: Species
is: HMDB00217

metaR CYSSERNaEx
kinetic law: MODEL1310110027#
reversible: false
name: L-serine/L-cysteine Na-dependent exchange (Cys-L in)
reactant: MODEL1310110027#
is: SBO:0000185
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
product: MODEL1310110027#
fast: false
is described by: ECO:0000269

metaR r0629
reversible: true
fast: false
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
is described by: ECO:0000000
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
is: SBO:0000176
modifier: MODEL1310110027#
product: MODEL1310110027#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.22
is version of: http://identifiers.org/ec-code/3.1.4.1
reactant: MODEL1310110027#

metaR EX HC02206 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin C1(1-) exchange
type: Reaction

metaM so3 m
boundary condition: false
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17137
has only substance units: false
is: HMDB00240
initial amount: NaN
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
name: hydrogensulfite

metaR GluForTx
kinetic law: MODEL1310110027#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Histidine metabolism EC Number: 2.1.2.5 Confidence Level: 4 AUTHORS: PMID:12815595 NOTES:SAB
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.1.2.5
reversible: false
is: SBO:0000176
name: Glutamate formimidoyltransferase
reactant: MODEL1310110027#
type: Reaction
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_69fbb3ba_5a92_4370_8fc3_86211d070844
constant: false
boundary condition: true
is encoded by: hsa:5464
is: SBO:0000252
is: Q15181
initial amount: NaN
has only substance units: false
name: PPA1
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_e32e0e06_4f16_4d08_a3b5_c4df7dab1db7
has only substance units: false
is encoded by: hsa:6785
initial amount: NaN
type: Species
boundary condition: true
name: ELOVL4
is: SBO:0000252
constant: false
is: Q9GZR5
initial concentration: NaN

metaR FAOXC163GC142m
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)gm
type: Reaction

metaM 13dpg c
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
name: 3-Phospho-D-glyceroyl phosphate
is: C00236
has only substance units: false
is: http://identifiers.org/pubchem.compound/3535
is: SBO:0000247
is: HMDB01270
constant: false
is: CHEBI:57604

metaR EX HC02207 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-c2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_32d80dc7_7092_4ca2_9346_685a489108a8
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:4952
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: OCRL

http://identifiers.org/biomodels.db/MODEL1310110027#_df959160_91b3_4454_9b7e_d08f3cf2c6c5
name: ALG8
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
is: A6NDW6
is encoded by: hsa:79053
boundary condition: true
has only substance units: false

metaM m8mpdol L r
boundary condition: false
has only substance units: false
name: (alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
constant: false
is: CHEBI:59093
is: SBO:0000247
type: Species
notes: FORMULA: C1780H2928N20O620P20 CHARGE: -20 INCHI: InChI=1S/C95H162N2O62P2/c1-34(2)13-9-14-35(3)15-10-16-36(4)17-11-18-37(5)19-12-20-38(6)21-22-138-160(132,133)159-161(134,135)158-86-53(97-40(8)108)64(119)77(49(31-106)147-86)150-85-52(96-39(7)107)63(118)78(48(30-105)146-85)151-91-76(131)80(153-94-84(71(126)60(115)46(28-103)144-94)157-95-83(70(125)59(114)47(29-104)145-95)156-90-74(129)67(122)56(111)43(25-100)141-90)62(117)51(149-91)32-136-87-75(130)79(152-93-82(69(124)58(113)45(27-102)143-93)155-89-73(128)66(121)55(110)42(24-99)140-89)61(116)50(148-87)33-137-92-81(68(123)57(112)44(26-101)142-92)154-88-72(127)65(120)54(109)41(23-98)139-88/h13,15,17,19,38,41-95,98-106,109-131H,9-12,14,16,18,20-33H2,1-8H3,(H,96,107)(H,97,108)(H,132,133)(H,134,135)/b35-15+,36-17+,37-19+/t38?,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77-,78-,79+,80+,81+,82+,83+,84+,85+,86-,87+,88-,89-,90-,91+,92+,93-,94-,95-/m1/s1 EHMN_ABBREVIATION: C05868
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110027#_22cf6092_0461_440f_8eaa_50cfc2a79be3
constant: false
is: Q13825
is encoded by: hsa:549
boundary condition: true
has only substance units: false
name: AUH
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252

metaM n2m2mn l
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: CHEBI:15428
notes: FORMULA: C42H71N3O31 CHARGE: 0
is: SBO:0000247
boundary condition: false
is: HMDB00123
initial concentration: 1.0
name: de-Fuc, reducing GlcNAc removed, de-Sia, de-Gal form of PA6 (w/o peptide linkage)

metaR FOLt2le
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: folate transport via anion exchange
reactant: MODEL1310110027#
is: SBO:0000185
kinetic law: MODEL1310110027#
is described by: ECO:0000134
reversible: true
fast: false
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_09e71040_4a2b_4d4e_b820_43be28092860
is: SBO:0000252
name: PGM2
boundary condition: true
is encoded by: hsa:55276
initial concentration: NaN
type: Species
is: Q96G03
initial amount: NaN
has only substance units: false
constant: false

metaR r1568
is: SBO:0000185
product: MODEL1310110027#
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110027#_9caa6900_9326_478c_a90d_af208d3c79e4
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:53354
name: PANK1
is: Q8TE04

http://identifiers.org/biomodels.db/MODEL1310110027#_4ff15895_a926_48fc_95f5_878423612dfd
constant: false
initial concentration: NaN
type: Species
name: PIK3CD:PIK3R1
boundary condition: true
has part: E7EX19
initial amount: NaN
is: SBO:0000297
has only substance units: false
is encoded by: hsa:5295

metaR r1614
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110027#
is: SBO:0000185
is described by: ECO:0000000

metaR UMPK5n
product: MODEL1310110027#
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (dATP),nuclear
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
modifier: MODEL1310110027#
reversible: true
fast: false

metaM Rtotal c
initial amount: NaN
name: R total
is: SBO:0000247
constant: false
notes: FORMULA: CO2FULLR CHARGE: -1
type: Species
boundary condition: false
is: CHEBI:16189
is: HMDB01448
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_97f55404_1f61_481c_893b_47ce89174658
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:H17063
name: _H17063_1_c
boundary condition: true

metaR r0517
type: Reaction
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
is version of: http://identifiers.org/ec-code/1.17.4.1
modifier: MODEL1310110027#
product: MODEL1310110027#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
kinetic law: MODEL1310110027#
fast: false
reactant: MODEL1310110027#

metaR RE2541E
modifier: MODEL1310110027#
is: SBO:0000176
reversible: true
type: Reaction
product: MODEL1310110027#
kinetic law: MODEL1310110027#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.31
name: RE2541
fast: false
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
reactant: MODEL1310110027#

metaM lac L x
is: SBO:0000247
initial amount: NaN
is: CHEBI:16651
is: HMDB00190
has only substance units: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
type: Species
constant: false
initial concentration: 1.0
name: (S)-lactate
boundary condition: false

metaM sphings c
name: sphingosine(1+)
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:57756
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
initial amount: NaN
type: Species
is: HMDB00252
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110027#_6a9b779e_15ac_430a_8fbe_145af87864c4
initial amount: NaN
name: RRM1:RRM2
is: SBO:0000297
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6240
boundary condition: true
has part: P31350
is encoded by: hsa:6241
has part: P23921

http://identifiers.org/biomodels.db/MODEL1310110027#_670e4726_e59c_4369_991d_b623de6fa530
is: SBO:0000252
is encoded by: hsa:2180
type: Species
name: ACSL1
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
is: P33121

metaR 2HBt2
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
name: 2-hydroxybutyrate cotransport with proton
is: SBO:0000185
product: MODEL1310110027#
type: Reaction
reactant: MODEL1310110027#
modifier: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_e1a42e71_194f_4acf_bbba_7cefa3af86f8
is: SBO:0000252
constant: false
is: Q16795
name: NDUFA9
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:4704

metaR PRPPS
is: SBO:0000176
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.6.1
product: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
fast: false
name: phosphoribosylpyrophosphate synthetase
reactant: MODEL1310110027#
modifier: MODEL1310110027#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110027#_801de097_e540_4bcb_85fd_b2ba924a8cb1
name: SLC7A11:SLC3A2
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000297
has part: Q9UPY5
initial amount: NaN
has only substance units: false
is encoded by: hsa:23657
constant: false

metaR r1260
reversible: false
product: MODEL1310110027#
kinetic law: MODEL1310110027#
fast: false
type: Reaction
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is described by: ECO:0000000
is: SBO:0000176
name: EC:6.2.1.3

metaR EX tre LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Trehalose exchange
type: Reaction

metaM cmp n
is: SBO:0000247
has only substance units: false
name: CMP(2-)
is: HMDB00095
is: CHEBI:60377
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055

metaM HC01415 m
has only substance units: false
type: Species
name: (2E)-Octenoyl-CoA
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:27537

metaM octd11ecoa m
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
name: 11-octadecenoylcoa
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
initial amount: NaN
is: HMDB02288

metaR PROSTGF2t
name: prostaglandin uniport
modifier: MODEL1310110027#
reactant: MODEL1310110027#
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110027#
product: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110027#_39dab6bd_551f_43a8_99da_ea716f5ac033
has only substance units: false
is: P23786
name: CPT2
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1376
constant: false
is: SBO:0000252
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_4b200f0a_7f9a_4d68_acad_a72c9de2d8f5
initial concentration: NaN
type: Species
is: SBO:0000252
name: PDE8B
is: O95263
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:8622

metaR r1615
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
fast: false
product: MODEL1310110027#
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110027#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110027#_b9def31d_c882_4aad_b16f_4d62c8bcc349
has only substance units: false
is: SBO:0000252
is: B7Z1R0
boundary condition: true
name: SLC4A10
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:57282

http://identifiers.org/biomodels.db/MODEL1310110027#_f51b8cf6_2eae_4210_883c_ae742755d978
initial amount: NaN
is encoded by: hsa:54965
is: Q8TBF5
constant: false
name: PIGX
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110027#_817659ba_c0fc_4a30_970c_47fb282e2cbd
type: Species
name: ST3GAL4
is: SBO:0000252
boundary condition: true
is: Q6IBE6
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6484
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_d791327e_1107_485b_926b_34277382cd8e
name: ST3GAL3
initial amount: NaN
type: Species
is encoded by: hsa:6487
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_4b9ea792_2ecc_437a_a3a4_3e3711e0b9ef
initial amount: NaN
boundary condition: true
constant: false
is: Q9UBY0
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: SLC9A2
is encoded by: hsa:6549
type: Species

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

metaR biomass reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
is: SBO:0000185
kinetic law: MODEL1310110027#
reversible: false
type: Reaction
fast: false
is described by: ECO:0000134
name: biomass_reaction
product: MODEL1310110027#
reactant: MODEL1310110027#

metaR r0830
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.5.4.16
reactant: MODEL1310110027#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
product: MODEL1310110027#
reversible: true
fast: false
type: Reaction
modifier: MODEL1310110027#

metaR GLYt7 211 r
kinetic law: MODEL1310110027#
fast: false
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is: SBO:0000185
type: Reaction
name: glycine reversible transport via sodium and chloride symport (2:1:1)

metaR r0594
reactant: MODEL1310110027#
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
type: Reaction
is: SBO:0000176
modifier: MODEL1310110027#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110027#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_ab74397e_8471_4be0_be44_9f210ac82982
initial concentration: NaN
type: Species
is: Q96P26
initial amount: NaN
name: NT5C1B
constant: false
is encoded by: hsa:93034
has only substance units: false
boundary condition: true
is: SBO:0000252

metaM ocdcea l
is: CHEBI:30823
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB00207
constant: false
name: oleate
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9- HEPATONET_1.0_ABBREVIATION: HC00510 EHMN_ABBREVIATION: C00712

metaR FMNAT
is: SBO:0000176
product: MODEL1310110027#
fast: false
type: Reaction
name: FMN adenylyltransferase
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
reversible: false
reactant: MODEL1310110027#
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.7.7.2

metaM docosahexcoa m
is: SBO:0000247
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
name: 3,7,10,13,16,19-docosahexenoylcoa
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
is: HMDB02288

metaM dcamp c
initial concentration: 1.0
is: HMDB00536
is: SBO:0000247
is: C03794
is: CHEBI:57567
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
name: N6-(1,2-Dicarboxyethyl)-AMP
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
type: Species

metaM 20ahchsterol m
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500
constant: false
is: HMDB06283
has only substance units: false
is: CHEBI:1296
type: Species
initial amount: NaN
name: 20-hydroxycholesterol

metaM co2 m
name: CO2
is: CHEBI:16526
is: C00011
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
boundary condition: false
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB01967
is: SBO:0000247

metaM m2gacpail hs r
initial concentration: 1.0
name: dimannosyl-glucosaminyl-acylphosphatidylinositol (H3)
is: SBO:0000247
type: Species
is: CHEBI:16038
constant: false
notes: FORMULA: C43H78NO24PFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
initial amount: NaN
has only substance units: false

metaR G14T19g
product: MODEL1310110027#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90
reactant: MODEL1310110027#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9334.1) or (8704.1) or (8703.1) or (8704.2) or (2683.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
fast: false
modifier: MODEL1310110027#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false
kinetic law: MODEL1310110027#

metaM 3octpencoa m
has only substance units: false
name: 3,6,9,12,15-octadecapentenoylcoa
type: Species
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB02288
initial amount: NaN
boundary condition: false

metaR r1616
reactant: MODEL1310110027#
fast: false
reversible: true
kinetic law: MODEL1310110027#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110027#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_fa850ebc_988a_4685_a361_d3448cac331d
type: Species
name: PIP5K1B
is: O14986
has only substance units: false
is encoded by: hsa:8395
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false

metaM gpi hs r
name: {[PE-Man-],[PE-]Man},{PE-}Man-GlcN-acylPI
notes: FORMULA: C55H106N4O38P4FULLRCO2FULLR2CO2 CHARGE: 0
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16038
type: Species
boundary condition: false
constant: false

metaR r0839
reactant: MODEL1310110027#
fast: false
is described by: ECO:0000000
product: MODEL1310110027#
name: Postulated transport reaction
is: SBO:0000185
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.70
modifier: MODEL1310110027#
reversible: true

metaR CITt4 4
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
reversible: true
is described by: ECO:0000006
type: Reaction
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
name: citrate transport via sodium symport
product: MODEL1310110027#
is: SBO:0000185
fast: false
reactant: MODEL1310110027#

metaM s2l2fn2m2masn e
is: HMDB00244
boundary condition: false
type: Species
is: C00255
has only substance units: false
name: PA6
notes: FORMULA: C90H145N6O65X CHARGE: -2
is: CHEBI:3554
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247

metaR PPAt
reversible: false
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8135845 NOTES:TDV
product: MODEL1310110027#
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000000
name: Propionate transport, diffusion

metaR EX udp LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP exchange
type: Reaction

metaR TCHOLAtx
reversible: true
name: bile acid intracellular transport
is: SBO:0000185
kinetic law: MODEL1310110027#
fast: false
is described by: ECO:0000000
product: MODEL1310110027#
reactant: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ

http://identifiers.org/biomodels.db/MODEL1310110027#_f3fe4dac_a375_4016_b66e_6d89e8598b44
constant: false
has only substance units: false
initial amount: NaN
type: Species
name: FH
is encoded by: hsa:2271
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: P07954

metaR GALASE20ly
reversible: false
product: MODEL1310110027#
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
type: Reaction
reactant: MODEL1310110027#
is described by: ECO:0000000
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4

http://identifiers.org/biomodels.db/MODEL1310110027#_f27487fb_7c68_426c_8438_64b67520a2dc
initial concentration: NaN
is: P23434
type: Species
has only substance units: false
is encoded by: hsa:2653
initial amount: NaN
name: GCSH
is: SBO:0000252
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_ef97a31f_6512_4035_9f05_5e1c92d84156
is: B7Z6S9
is: SBO:0000252
name: GBA
is encoded by: hsa:2629
type: Species
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR r1565
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110027#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
product: MODEL1310110027#
kinetic law: MODEL1310110027#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM mal L m
boundary condition: false
name: (S)-malate(2-)
is: CHEBI:15589
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB00156
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_a258a988_f8de_4c8b_bf11_8ca2891169f4
constant: false
is: P56181
name: NDUFV3
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:4731
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaM ksii core4 pre2 g
is: HMDB00175
notes: FORMULA: C47H76N4O33X CHARGE: -1
has only substance units: false
is: SBO:0000247
constant: false
name: keratan sulfate II boisynthesis, precursor 2
boundary condition: false
is: CHEBI:58053
initial amount: NaN
is: C00130
initial concentration: 1.0
type: Species

metaR SPMDOX
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
name: Spermidine:(acceptor) oxidoreductase
product: MODEL1310110027#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: beta-Alanine metabolism EC Number: 1.5.99.6 Confidence Level: 2 AUTHORS: PMID:10657958 NOTES:SAB
fast: false
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110027#_b3ca9156_ec19_4652_90ea_1f9c89d8082a
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4539
type: Species
is: Q7GXZ4
name: ND4L

http://identifiers.org/biomodels.db/MODEL1310110027#_232049c3_9348_417e_99b1_cb4acf15d2ff
initial amount: NaN
constant: false
is: O00400
initial concentration: NaN
is encoded by: hsa:9197
is: SBO:0000252
has only substance units: false
boundary condition: true
name: SLC33A1
type: Species

metaM 3odcoa m
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB03939
is: CHEBI:28528
name: 3-Oxodecanoyl-CoA

metaR FUMSO4tm
name: Fumarate:sulfate antiport, mitochondrial
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is: SBO:0000185
kinetic law: MODEL1310110027#
fast: false
type: Reaction
reactant: MODEL1310110027#
product: MODEL1310110027#
reversible: true
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110027#_2ae4b116_7ff9_4e36_9bb3_f12b3242c4b6
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
type: Species
is encoded by: hsa:5277
is: SBO:0000252
boundary condition: true
name: PIGA

metaR r2039
is: SBO:0000185
reactant: MODEL1310110027#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110027#
modifier: MODEL1310110027#
fast: false
kinetic law: MODEL1310110027#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaM chsterol r
type: Species
constant: false
has only substance units: false
boundary condition: false
is: HMDB00067
is: CHEBI:16113
initial amount: NaN
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
name: cholesterol
is: SBO:0000247
initial concentration: 1.0

metaM HC02217 c
initial concentration: 1.0
is: CHEBI:27647
name: prostaglandin-g2
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110027#_e8d5cc70_6542_49ab_8d35_967902e32492
initial amount: NaN
type: Species
is encoded by: hsa:8869
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: Q9UNP4
name: ST3GAL5
boundary condition: true
constant: false

metaR LEUKTRF4t
name: leukotriene F4 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110027#
fast: false
reversible: true
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110027#
is described by: ECO:0000000
product: MODEL1310110027#

metaR r1564
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110027#
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110027#
kinetic law: MODEL1310110027#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true

metaR GLYt2r
is: SBO:0000185
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
kinetic law: MODEL1310110027#
product: MODEL1310110027#
is described by: ECO:0000304
type: Reaction
reactant: MODEL1310110027#
modifier: MODEL1310110027#
name: glycine reversible transport via proton symport
reversible: true
fast: false

metaM 6dhf e
name: hexaglutamyl folate (DHF)
initial concentration: 1.0
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
type: Species
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB06563

metaM accoa g
has only substance units: false
initial amount: NaN
constant: false
is: HMDB01206
boundary condition: false
is: CHEBI:57288
name: acetyl-CoA(4-)
initial concentration: 1.0
type: Species
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_edf8b5bc_6d95_48db_ab15_5fe87ed36697
type: Species
has only substance units: false
constant: false
name: _AI285872_1_c
is encoded by: hsa:AI285872
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_91742a30_b748_4f01_b857_6dee4269d9f6
has only substance units: false
is: P04183
type: Species
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
name: TK1
initial concentration: NaN
is encoded by: hsa:7083

metaM sphgn c
name: sphinganine(1+)
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:57817
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
constant: false
is: HMDB00269
has only substance units: false
type: Species

metaR CYOOm3
type: Reaction
is version of: http://identifiers.org/ec-code/1.9.3.1
is described by: ECO:0000134
product: MODEL1310110027#
reactant: MODEL1310110027#
fast: false
is: SBO:0000185
modifier: MODEL1310110027#
reversible: false
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
name: cytochrome c oxidase, mitochondrial Complex IV
kinetic law: MODEL1310110027#

metaR DCATDr
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Decanoate (n-C10:0) into the E.R. by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_32d3b65b_bc9c_466e_9531_b407885aaa31
constant: false
has only substance units: false
initial concentration: NaN
is: Q9UHV8
is encoded by: hsa:29124
boundary condition: true
is: SBO:0000252
name: LGALS13
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_afd7c8b7_22e7_4b67_873a_a917475808f3
boundary condition: true
type: Species
is encoded by: hsa:217
name: ALDH2
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
is: P05091
initial amount: NaN

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

metaM occoa x
has only substance units: false
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
name: Octanoyl-CoA (n-C8:0CoA)
is: HMDB01070
initial amount: NaN
constant: false
type: Species
is: C01944
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57386
boundary condition: false

metaM ksi pre36 g
initial concentration: 1.0
is: CHEBI:28067
notes: FORMULA: C247H394N17O210S11X CHARGE: -12
constant: false
name: keratan sulfate I biosynthesis, precursor 36
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false

metaR CITt4 2
is: SBO:0000185
reactant: MODEL1310110027#
name: citrate transport via sodium symport
product: MODEL1310110027#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110027#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
kinetic law: MODEL1310110027#

metaR r0627
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110027#
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110027#
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:

metaM gdpfuc c
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
initial amount: NaN
has only substance units: false
is: HMDB01095
name: GDP-L-fucose(2-)
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:57984
type: Species

metaM pe hs m
name: phosphatidylethanolamine
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
boundary condition: false
is: CHEBI:16038
is: SBO:0000247

metaR r0413
product: MODEL1310110027#
reversible: false
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
modifier: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
name: dATP:pyruvate O2-phosphotransferase Purine metabolism EC:2.7.1.40
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110027#_96468412_de5f_4e08_bd11_f5dc2802d4ac
is: D3DWC4
type: Species
is encoded by: hsa:259230
name: SGMS1
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

metaM trp L c
has only substance units: false
name: L-tryptophan
is: HMDB00929
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:16828
is: SBO:0000247
constant: false
type: Species

metaR r1567
product: MODEL1310110027#
fast: false
type: Reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110027#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110027#
is: SBO:0000185

metaR HISTAtu
is described by: ECO:0000269
fast: false
type: Reaction
name: Histamine uniport
product: MODEL1310110027#
kinetic law: MODEL1310110027#
is: SBO:0000185
reversible: true
reactant: MODEL1310110027#
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ

metaR NDPK2n
reactant: MODEL1310110027#
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
reversible: true
fast: false
product: MODEL1310110027#
is described by: ECO:0000269
name: nucleoside-diphosphate kinase (ATP:UDP), nuclear
type: Reaction
kinetic law: MODEL1310110027#
is: SBO:0000176

metaR EX tcynt LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

metaR PSSA2 hs
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.8.29
kinetic law: MODEL1310110027#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (81490.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylethanolamine version as substrate NJ
modifier: MODEL1310110027#
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110027#
reversible: true
name: Phosphatidylserine synthase homo sapiens

metaM 3mop e
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
type: Species
is: CHEBI:28654
is: HMDB00491
initial concentration: 1.0
initial amount: NaN
name: 3-methyl-2-oxopentanoate
boundary condition: false

metaR GHMT2r
fast: false
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.1.2.1
reversible: true
kinetic law: MODEL1310110027#
name: glycine hydroxymethyltransferase, reversible
is: SBO:0000176
notes: GENE_ASSOCIATION: (6470.1) or (6470.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
type: Reaction
product: MODEL1310110027#
is described by: ECO:0000269
modifier: MODEL1310110027#

metaM glc D r
constant: false
initial concentration: 1.0
type: Species
name: D-glucose
is: CHEBI:4167
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB00122
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
boundary condition: false

metaM ditp n
type: Species
initial concentration: 1.0
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
is: SBO:0000247
is: HMDB03537
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:61382
has only substance units: false
name: dITP(4-)

metaR GGH 5DHFl
product: MODEL1310110027#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.4.19.9
modifier: MODEL1310110027#
type: Reaction
reactant: MODEL1310110027#
name: Gamma-glutamyl hydrolase (5DHF), lysosomal
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT

metaR FAOXC122m
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)m
type: Reaction

metaM nadp m
has only substance units: false
is: HMDB00217
initial concentration: 1.0
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
type: Species
constant: false
initial amount: NaN
is: C00006
boundary condition: false
is: CHEBI:58349
is: SBO:0000247
name: Nicotinamide adenine dinucleotide phosphate

metaR 3HBCOAHLm
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
reversible: false
type: Reaction
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
is: SBO:0000176
product: MODEL1310110027#
fast: false

metaR PROSTGE1t
name: prostaglandin transport via bicarbonate countertransport
reactant: MODEL1310110027#
is: SBO:0000185
kinetic law: MODEL1310110027#
is described by: ECO:0000269
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
type: Reaction
fast: false
reversible: true
modifier: MODEL1310110027#

metaR r1566
reactant: MODEL1310110027#
product: MODEL1310110027#
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110027#

metaR HISCAT1
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

metaM malttr e
type: Species
constant: false
has only substance units: false
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
name: maltotriose
is: SBO:0000247
boundary condition: false
is: CHEBI:27931
initial concentration: 1.0
is: HMDB01262
is: C01835
initial amount: NaN

metaM 4nph e
name: 4-nitrophenolate
is: CHEBI:57917
is: HMDB01232
constant: false
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaM malcoa c
is: HMDB01175
type: Species
is: C00083
constant: false
initial concentration: 1.0
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
boundary condition: false
is: SBO:0000247
is: CHEBI:57384
has only substance units: false
initial amount: NaN
name: Malonyl-CoA

metaR NRPPHRt4 2 r
fast: false
product: MODEL1310110027#
modifier: MODEL1310110027#
name: Norepinephrine reversible transport in via sodium symport (1:2)
kinetic law: MODEL1310110027#
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reactant: MODEL1310110027#
is described by: ECO:0000269

metaR RADH3
kinetic law: MODEL1310110027#
name: retinal dehydrogenase
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110027#
is: SBO:0000176
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:11606944 NOTES:IT

metaM ksi pre25 g
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 25
is: C00130
initial amount: NaN
is: CHEBI:58053
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C199H319N14O163S7X CHARGE: -8
constant: false
is: HMDB00175
initial concentration: 1.0

metaR FAOXC102m
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_38b2b3aa_0458_4159_96ab_00fb5522ee29
boundary condition: true
is: SBO:0000252
name: DHCR24
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:1718
initial concentration: NaN
has only substance units: false
is: Q15392

metaR NDP7er
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
fast: false
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum
type: Reaction
reversible: false
product: MODEL1310110027#
is: SBO:0000176

metaR FAOXC225C226m
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)m
type: Reaction

metaM retinol 9 cis c
initial concentration: 1.0
is: HMDB06217
type: Species
is: CHEBI:17336
constant: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
is: SBO:0000247
has only substance units: false
boundary condition: false
name: 9-cis-retinol
initial amount: NaN

metaM pd3 c
is: HMDB06500
has only substance units: false
boundary condition: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h10,12-13,19,21,24-26,28H,6-9,11,14-18H2,1-5H3/b13-12-/t21-,24+,25-,26?,27-/m1/s1
initial amount: NaN
name: Previtamin D3
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false

metaR r2141
modifier: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110027#
reactant: MODEL1310110027#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false

metaR r0835
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.5.4.16
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
modifier: MODEL1310110027#
is described by: ECO:0000000
kinetic law: MODEL1310110027#
reversible: true
product: MODEL1310110027#
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:

metaR r0722
type: Reaction
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110027#
product: MODEL1310110027#
reversible: true
fast: false
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is version of: http://identifiers.org/ec-code/4.2.3.12

metaR r1561
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110027#
fast: false
kinetic law: MODEL1310110027#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110027#
is: SBO:0000185
reversible: true

metaR r0186
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
type: Reaction
is: SBO:0000176
product: MODEL1310110027#
reactant: MODEL1310110027#
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
fast: false
kinetic law: MODEL1310110027#
reversible: false

metaM 4abut m
is: HMDB00112
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
initial concentration: 1.0
has only substance units: false
name: 4-Aminobutanoate
is: C00334
type: Species
is: CHEBI:16865
is: SBO:0000247

metaM 3mop c
name: 3-methyl-2-oxopentanoate
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB00491
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
has only substance units: false
type: Species
is: CHEBI:28654

metaR r0480
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110027#
is: SBO:0000176
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
reactant: MODEL1310110027#
product: MODEL1310110027#
fast: false

metaM co2 c
notes: FORMULA: CO2 CHARGE: 0
constant: false
initial concentration: 1.0
is: C00011
name: CO2
is: HMDB01967
boundary condition: false
is: CHEBI:3313
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247

metaM cmp c
name: CMP
is: C00055
constant: false
initial concentration: 1.0
is: CHEBI:60377
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: HMDB00095
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_f6111834_49cd_422a_88fa_29a64d279be9
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:115111
name: SLC26A7
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110027#_0000f837_6521_4623_94b1_c0fcf4ad0546
has only substance units: false
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
name: GLRX
is encoded by: hsa:2745
boundary condition: true
is: P35754

metaR DOLMANP Lter
is: SBO:0000185
kinetic law: MODEL1310110027#
reversible: false
reactant: MODEL1310110027#
type: Reaction
product: MODEL1310110027#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
name: dolichol-phosphate mannose flippase (liver)
fast: false

http://identifiers.org/biomodels.db/MODEL1310110027#_30baeb67_5fc8_457b_a183_353ba412723c
initial concentration: NaN
name: _BE966236_1_m
constant: false
boundary condition: true
type: Species
is encoded by: hsa:BE966236
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaM CE5101 m
type: Species
constant: false
is: SBO:0000247
is: CHEBI:57795
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101

metaR r2140
is: SBO:0000185
type: Reaction
reactant: MODEL1310110027#
product: MODEL1310110027#
modifier: MODEL1310110027#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
reversible: true
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR r0836
kinetic law: MODEL1310110027#
reversible: true
fast: false
product: MODEL1310110027#
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.16
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reactant: MODEL1310110027#
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110027#_f4dcf3b2_5051_4000_8bf2_d9f2286e9c8e
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:23533
is: Q8WYR1
type: Species
name: PIK3R5
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true

metaR r0723
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.41
product: MODEL1310110027#
is described by: ECO:0000000
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
reversible: false
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
fast: false
type: Reaction
reactant: MODEL1310110027#

metaR A MANASEly
modifier: MODEL1310110027#
product: MODEL1310110027#
reversible: false
notes: GENE_ASSOCIATION: (4125.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES:NCD
is: SBO:0000176
type: Reaction
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.2.1.24
kinetic law: MODEL1310110027#
is described by: ECO:0000000
fast: false
name: alpha-mannosidase, lysosomal

metaR PAPtg
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
is: SBO:0000185
product: MODEL1310110027#
reversible: false
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
name: adenosine 3',5'-bisphosphate Golgi transport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_bf8dd42f_9070_4a63_b166_cfd618bf38a7
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1120
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: CHKB
is: A0PJM6
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_1086c92f_a854_4df0_a11d_7a1f012f8f0b
is: SBO:0000252
constant: false
name: FOLR1
type: Species
initial concentration: NaN
is encoded by: hsa:2348
initial amount: NaN
has only substance units: false
boundary condition: true

metaR r1560
fast: false
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110027#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM accoa c
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: SBO:0000247
is: CHEBI:57288
type: Species
name: Acetyl-CoA
is: C00024
is: HMDB01206

metaR PHEACGLNt
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14681857 NOTES:SAB
name: PHEACGLN extracellular transport via diffusion
type: Reaction
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110027#_ab0178ef_bd59_4b7c_b8e5_7887ada5e9fa
constant: false
is encoded by: hsa:347734
type: Species
name: SLC35B2
has only substance units: false
is: SBO:0000252
is: Q8TB61
initial amount: NaN
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_13eff8da_84a0_485d_86b0_574fa2889dcc
initial amount: NaN
is: E9PCI1
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:53
has only substance units: false
name: ACP2
initial concentration: NaN
constant: false

metaM ocdcea r
name: octadecenoate (n-C18:1)
is: C00712
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:0
notes: FORMULA: C18H33O2 CHARGE: -1
is: HMDB00207
type: Species
initial concentration: 1.0

metaM hpyr c
is: CHEBI:17180
name: 3-hydroxypyruvate
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C3H3O4 CHARGE: -1 INCHI: InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00163 EHMN_ABBREVIATION: C00168
is: HMDB01352

http://identifiers.org/biomodels.db/MODEL1310110027#_81ac34ee_45a3_4096_a32f_ee6fe84f5f81
boundary condition: true
is: O14556
type: Species
is: SBO:0000252
initial amount: NaN
name: GAPDHS
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:26330

metaR r0724
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is: SBO:0000176
fast: false
is described by: ECO:0000000
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.1.33
kinetic law: MODEL1310110027#
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
type: Reaction
reactant: MODEL1310110027#
modifier: MODEL1310110027#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110027#_e8eecd86_acef_4260_a389_f7f11fb90b64
initial amount: NaN
name: NDUFA5
is encoded by: hsa:4698
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is: Q16718
constant: false

metaM ksii core2 deg5 l
type: Species
name: keratan sulfate II (core 2-linked), degradation product 5
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:12936
has only substance units: false
is: HMDB00143
notes: FORMULA: C50H82N4O38SX CHARGE: -1
constant: false
initial concentration: 1.0

metaR LEUTAm
is: SBO:0000176
kinetic law: MODEL1310110027#
product: MODEL1310110027#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.6.1.42
name: leucine transaminase, mitochondrial
reactant: MODEL1310110027#
fast: false
modifier: MODEL1310110027#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110027#_05e5fac4_7aad_4ef7_a82c_0834f55ce297
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
is: O15305
name: PMM2
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:5373

metaM HC01115 c
type: Species
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
is: SBO:0000247
name: NeuNGc
is: CHEBI:29025
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false

metaM thbpt4acam c
has only substance units: false
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
initial concentration: 1.0
name: 4a-hydroxytetrahydrobiopterin
constant: false
is: CHEBI:15374
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB02281

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

metaR EX cyan LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen cyanide exchange
type: Reaction

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

metaR AKR1C1
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.1.20
product: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
reversible: false
is: SBO:0000176
name: aldo-keto reductase family 1, member C1 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
notes: GENE_ASSOCIATION: (1645.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.1.20 Confidence Level: 4 AUTHORS: PMID:8486699 NOTES:NJ
modifier: MODEL1310110027#
reactant: MODEL1310110027#
fast: false

metaM cmp e
name: CMP(2-)
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB00095
constant: false
has only substance units: false
is: CHEBI:60377
initial amount: NaN
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055

metaM co2 e
is: C00011
is: SBO:0000247
initial concentration: 1.0
type: Species
name: CO2
boundary condition: false
constant: false
is: CHEBI:16526
has only substance units: false
initial amount: NaN
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: HMDB01967

metaR DIDPtn
fast: false
reversible: true
name: dIDP nuclear transport
type: Reaction
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
is: SBO:0000185
product: MODEL1310110027#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaR SUCCOAPET
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of succinyl coa for release into cytosol
type: Reaction

metaR r1563
reactant: MODEL1310110027#
product: MODEL1310110027#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110027#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110027#_dd0172a6_3c34_4879_84ff_308bbc4e0f65
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:BE042354
type: Species
initial amount: NaN
name: _BE042354_1_m
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_94fa8788_63db_413a_8cbe_9161103dae84
is encoded by: hsa:6319
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
is: O00767
constant: false
initial amount: NaN
name: SCD
initial concentration: NaN

metaM HC02217 e
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
boundary condition: false
initial amount: NaN
is: CHEBI:27647
constant: false
type: Species
initial concentration: 1.0
name: prostaglandin-g2
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_dbf53932_e054_42d2_9ed7_38798911f20a
is encoded by: hsa:5232
is: SBO:0000252
initial concentration: NaN
is: P07205
has only substance units: false
name: PGK2
boundary condition: true
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_e48f9526_4273_41a1_a8ad_89f40144b109
name: _R33828_1_c
type: Species
initial concentration: NaN
is encoded by: hsa:R33828
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaM dec24dicoa m
is: HMDB01168
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
constant: false
type: Species
name: 2,4-decadienoylcoa
initial amount: NaN

metaR LEUTA
kinetic law: MODEL1310110027#
product: MODEL1310110027#
is: SBO:0000176
name: leucine transaminase
type: Reaction
reversible: true
modifier: MODEL1310110027#
fast: false
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
is version of: http://identifiers.org/ec-code/2.6.1.42
is described by: ECO:0000269

metaR DM dttp m
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: dTTP demand
type: Reaction

metaR r2142
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
fast: false
modifier: MODEL1310110027#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
is: SBO:0000185
type: Reaction

metaR r0838
is version of: http://identifiers.org/ec-code/3.1.2.4
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
kinetic law: MODEL1310110027#
type: Reaction
modifier: MODEL1310110027#
name: Free diffusion
fast: false
reversible: true
reactant: MODEL1310110027#
product: MODEL1310110027#
is described by: ECO:0000000
is: SBO:0000185

metaM s2l2fn2m2masn l
notes: FORMULA: C90H145N6O65X CHARGE: -2
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:18287
is: HMDB00174
initial concentration: 1.0
constant: false
name: PA6
is: SBO:0000247
type: Species

metaM sebacid c
name: sebacicacid
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C10H16O4 CHARGE: -2
is: C08277
is: HMDB00792
type: Species
boundary condition: false
is: SBO:0000247

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

metaR AG13T11g
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
product: MODEL1310110027#
reversible: false
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

metaR 4NPHte
product: MODEL1310110027#
is described by: ECO:0000000
is: SBO:0000185
name: xenobiotic transport
type: Reaction
kinetic law: MODEL1310110027#
fast: false
reactant: MODEL1310110027#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8385949,PMID:9219629 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Physiological, Rat

metaM CE2838 e
is: SBO:0000247
name: maltononaose
is: http://identifiers.org/pubchem.compound/5041
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
constant: false
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
is: C01936
boundary condition: false

metaM 4abut n
name: 4-Aminobutanoate
initial concentration: 1.0
notes: FORMULA: C4H9NO2 CHARGE: 0
is: C00334
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
is: HMDB00112
constant: false

metaR ALADGLNexR
reversible: true
fast: false
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
name: L-alanine/glutamine reversible exchange
type: Reaction
is described by: ECO:0000304
reactant: MODEL1310110027#
is: SBO:0000185
modifier: MODEL1310110027#
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_4aa5043b_736e_4761_9fbb_63192d2964eb
type: Species
is encoded by: hsa:3988
boundary condition: true
initial concentration: NaN
is: P38571
name: LIPA
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR r1562
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110027#
product: MODEL1310110027#
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110027#
reversible: true

metaM ins e
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
is: CHEBI:17596
is: HMDB00195
constant: false
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
name: Inosine
initial amount: NaN
is: C00294
initial concentration: 1.0

metaR r0410
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110027#
fast: false
type: Reaction
reactant: MODEL1310110027#
is: SBO:0000176
product: MODEL1310110027#
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:

metaR ACACT1r
kinetic law: MODEL1310110027#
product: MODEL1310110027#
type: Reaction
name: acetyl-CoA C-acetyltransferase
is version of: http://identifiers.org/ec-code/2.3.1.9
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:JLR- reversible form of ACACT1
reversible: true
modifier: MODEL1310110027#
reactant: MODEL1310110027#
is: SBO:0000176
fast: false

metaM leuktrF4 e
boundary condition: false
name: leukotriene F4
is: HMDB06465
initial concentration: 1.0
is: CHEBI:27491
constant: false
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_861aabcd_352b_4c14_ab28_ce7adbe1ac85
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: NDUFA6
is: P56556
type: Species
constant: false
has only substance units: false
is encoded by: hsa:4700
is: SBO:0000252

metaM ksi e
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
has only substance units: false
is: HMDB00211
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: keratan sulfate I
constant: false
is: CHEBI:17268
initial amount: NaN

metaR r2371
is described by: ECO:0000000
kinetic law: MODEL1310110027#
is: SBO:0000185
product: MODEL1310110027#
reactant: MODEL1310110027#
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction

metaR r0630
kinetic law: MODEL1310110027#
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
type: Reaction
modifier: MODEL1310110027#
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
is described by: ECO:0000000
reactant: MODEL1310110027#
fast: false
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/3.1.3.1
is version of: http://identifiers.org/ec-code/3.1.3.2

metaM 10fthf m
has only substance units: false
is: HMDB00972
is: SBO:0000247
initial amount: NaN
is: CHEBI:57454
name: 10-formyltetrahydrofolate(2-)
boundary condition: false
constant: false
type: Species
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
initial concentration: 1.0

metaR RE1522M
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#
fast: false
reversible: true
name: RE1522
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
product: MODEL1310110027#
is described by: ECO:0000000
modifier: MODEL1310110027#

metaR r0483
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:

metaR BALAtmr
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
product: MODEL1310110027#
is described by: ECO:0000000
reversible: true
name: Beta-alanine reversible mitochondrial transport (diffusion)
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
is: SBO:0000185
type: Reaction

metaR BDMT L
modifier: MODEL1310110027#
fast: false
kinetic law: MODEL1310110027#
reversible: false
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (56052.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES:NCD
name: GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (liver)
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.142
reactant: MODEL1310110027#

metaM q10 e
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
is: HMDB01072
initial amount: NaN
has only substance units: false
is: CHEBI:46245
name: ubiquinone-10

metaM lac L c
is: SBO:0000247
name: (S)-lactate
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
type: Species
is: CHEBI:16651
constant: false
has only substance units: false
is: HMDB00190
initial amount: NaN

metaR BAAT1x
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.65
fast: false
reactant: MODEL1310110027#
is: SBO:0000176
product: MODEL1310110027#
kinetic law: MODEL1310110027#
is described by: ECO:0000269
reversible: false
name: bile acid Coenzyme A: amino acid N-acyltransferase
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
modifier: MODEL1310110027#

metaR M16NTg
reactant: MODEL1310110027#
name: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
modifier: MODEL1310110027#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.4.1.143
type: Reaction
notes: GENE_ASSOCIATION: (4247.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.143 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
kinetic law: MODEL1310110027#
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110027#_c47625cd_4ed6_484e_9339_a163488a87b0
type: Species
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: P37287
boundary condition: true
is encoded by: hsa:5277
name: PIGA
is: SBO:0000252

metaR PTPAT
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.3
product: MODEL1310110027#
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
reactant: MODEL1310110027#
name: Phosphopantetheine adenylyltransferase (EC 2.7.7.3)
is described by: ECO:0000269
is: SBO:0000176
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110027#_1a2a769f_1f29_4316_bade_b8e601b8c1b0
constant: false
initial amount: NaN
has only substance units: false
is: Q8NFF5
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:80308
name: FLAD1

metaR UMPK3
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
name: UMP kinase (UTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110027#

metaR LNLCt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
product: MODEL1310110027#
is: SBO:0000185
reactant: MODEL1310110027#
is described by: ECO:0000000
name: Linoleic acid (n-C18:2) transport in via diffusion
fast: false
reversible: true
kinetic law: MODEL1310110027#

metaR KSIt
product: MODEL1310110027#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
type: Reaction
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: keratan sulfate I transport, golgi to extracellular

metaR r0408
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
product: MODEL1310110027#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
fast: false
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.5

http://identifiers.org/biomodels.db/MODEL1310110027#_48e4b021_7d10_444c_9f47_ebef52ad646e
is: SBO:0000252
is encoded by: hsa:3418
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
type: Species
name: IDH2
is: P48735
initial amount: NaN

metaM CE2418 m
constant: false
is: SBO:0000247
is: CHEBI:28387
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
type: Species
is: HMDB11123
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
has only substance units: false

metaM 5aop m
is: C00430
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
is: HMDB01149
constant: false
type: Species
name: 5-Amino-4-oxopentanoate
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17549
initial amount: NaN

metaM triodthy e
type: Species
constant: false
initial concentration: 1.0
is: HMDB00265
initial amount: NaN
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
boundary condition: false
is: SBO:0000247
is: CHEBI:18258
name: 3,3',5-triiodo-L-thyronine
has only substance units: false

metaM forglu c
is: HMDB00854
notes: FORMULA: C6H8N2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00357 EHMN_ABBREVIATION: C00439
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: C00439
name: N-Formimidoyl-L-glutamate
constant: false
is: SBO:0000247
type: Species
is: CHEBI:18327
initial amount: NaN

metaR r1493
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:15845416 NOTES:
type: Reaction
reversible: false
product: MODEL1310110027#
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#

metaR AG13T6g
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
product: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110027#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110027#
modifier: MODEL1310110027#
is: SBO:0000176
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110027#_4e3e10f0_c85a_4cbd_ad68_b02f02ee6cd8
initial concentration: NaN
is: P27707
is encoded by: hsa:1633
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
name: DCK
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_67bfbfef_c191_47e3_996c_67c3e6d221eb
has only substance units: false
type: Species
name: ACADL
initial amount: NaN
is encoded by: hsa:33
is: P28330
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252

metaR UMPK2
name: UMP kinase (CTP)
is described by: ECO:0000269
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110027#
product: MODEL1310110027#
kinetic law: MODEL1310110027#
is: SBO:0000176
type: Reaction

metaR DOLPGT1 Ler
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
product: MODEL1310110027#
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (liver)
notes: GENE_ASSOCIATION: (29929.1) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
reversible: false
is: SBO:0000176
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.4.1.267
type: Reaction
fast: false
is described by: ECO:0000000

metaR COt
is described by: ECO:0000000
fast: false
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
product: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#
name: CO transporter via diffusion
reversible: true
is: SBO:0000185

metaR UDPG4E
is: SBO:0000176
fast: false
is described by: ECO:0000134
type: Reaction
product: MODEL1310110027#
reactant: MODEL1310110027#
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/5.1.3.2
reversible: true
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Galactose metabolism EC Number: 5.1.3.2 Confidence Level: 0 AUTHORS: PMID:11117433 NOTES:used yeast system to overexpress gene to determine mutant kinetic properties
name: UDPglucose 4-epimerase

metaM accoa n
initial amount: NaN
is: CHEBI:57288
constant: false
is: SBO:0000247
name: acetyl-CoA(4-)
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
initial concentration: 1.0
boundary condition: false
is: HMDB01206
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_81b34c71_70b7_42a3_94ce_fc3cac836583
has only substance units: false
initial concentration: NaN
constant: false
type: Species
name: _AI378339_1_m
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AI378339

http://identifiers.org/biomodels.db/MODEL1310110027#_0c4a307f_6eea_4b55_a450_912da0d23253
initial amount: NaN
constant: false
has only substance units: false
is: C9JFZ1
is: SBO:0000252
name: SYNJ1
type: Species
initial concentration: NaN
is encoded by: hsa:8867
boundary condition: true

metaR r0407
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110027#
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.4.3.5
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
reversible: true
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#

metaR r2373
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
is: SBO:0000185
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_76e3a4a4_5a98_4c47_b289_a52520d90085
has only substance units: false
constant: false
name: MGLL
is encoded by: hsa:11343
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
is: B2ZGL7

http://identifiers.org/biomodels.db/MODEL1310110027#_2cf98499_8e32_4be8_84ee_fa6ef5ea2c00
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:212
has only substance units: false
name: ALAS2
is: SBO:0000252
is: Q5JZF5
initial amount: NaN
boundary condition: true

metaM thbpt4acam n
type: Species
initial amount: NaN
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
name: 4a-hydroxytetrahydrobiopterin
is: SBO:0000247
boundary condition: false
is: CHEBI:15374
is: HMDB02281
constant: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_3f6c57e3_40f6_4853_bf68_2959cffd0c77
initial concentration: NaN
initial amount: NaN
name: CDIPT
constant: false
type: Species
is encoded by: hsa:10423
has only substance units: false
boundary condition: true
is: SBO:0000252
is: O14735

metaR DUDPtn
is: SBO:0000185
fast: false
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
product: MODEL1310110027#
is described by: ECO:0000000
reversible: true
name: dUDP nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction

metaR r1492
name: Utilized transport
is: SBO:0000185
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
type: Reaction
fast: false
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_a4495007_5b0b_4cb2_908b_61f4b1a191e6
initial amount: NaN
name: DGKI
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: O75912
constant: false
is encoded by: hsa:9162
type: Species

metaR G3PD1
reversible: true
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
kinetic law: MODEL1310110027#
fast: false
name: glycerol-3-phosphate dehydrogenase (NAD)
modifier: MODEL1310110027#
is described by: ECO:0000269
product: MODEL1310110027#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.1.1.8

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

metaR FAOXC101m
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)m
type: Reaction

metaR r1865
name: Y+LAT2 Utilized transport
fast: false
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110027#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110027#
reversible: false
product: MODEL1310110027#
type: Reaction

metaM dcsptn1crn m
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
name: docosa-4,7,10,13,16-pentaenoyl carnitine
is: HMDB06321
constant: false
initial concentration: 1.0
boundary condition: false
type: Species

metaR r2372
is described by: ECO:0000000
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
fast: false
is: SBO:0000185
type: Reaction

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_85780f6a_b7c2_4f62_9172_75657f7acfc1
is encoded by: hsa:5151
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
name: PDE8A
boundary condition: true
initial amount: NaN
has only substance units: false

metaM succ x
is: HMDB00254
is: C00042
initial concentration: 1.0
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
name: Succinate
is: CHEBI:30031

http://identifiers.org/biomodels.db/MODEL1310110027#_968f771a_6248_49ed_b5e5_c9a8b57f21e5
name: SLC7A1
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is: P30825
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6541

http://identifiers.org/biomodels.db/MODEL1310110027#_7d9a52f8_8b31_4e62_8830_7789da119e98
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1329
is: Q53YB7
boundary condition: true
initial concentration: NaN
name: COX5B
constant: false
type: Species

metaM gam c
is: C00329
boundary condition: false
type: Species
name: D-Glucosamine
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17315
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
has only substance units: false
is: HMDB01514
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_f48edc7c_3d7f_4f5b_b918_8226bf11a5c7
is encoded by: hsa:6817
type: Species
name: SULT1A1
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252

metaM nadh c
is: http://identifiers.org/pubchem.compound/3306
has only substance units: false
constant: false
type: Species
is: C00004
name: Nicotinamide adenine dinucleotide - reduced
is: HMDB01487
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57945

metaR EX q10 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinone
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_5e7faae1_b668_477e_9532_1d6364c3609f
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: DPM3
is encoded by: hsa:54344
is: Q9P2X0
type: Species
is: SBO:0000252
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_93bd85f2_5a62_4da1_9b6e_a5bb416b742f
name: MANBA
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:4126
is: O00462
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_359ece18_a7c9_4b8b_b154_987adcf220ec
is: Q4FEB3
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is: SBO:0000252
name: CMA1
initial amount: NaN
boundary condition: true
is encoded by: hsa:1215

metaR r0941
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:
fast: false
reversible: true
name: Free diffusion
is described by: ECO:0000000
product: MODEL1310110027#

metaM glc D g
is: CHEBI:4167
name: D-glucose
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
type: Species
is: HMDB00122
initial amount: NaN

metaR EX c4dc
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for succinyl carnitine
type: Reaction

metaR r2435
type: Reaction
product: MODEL1310110027#
kinetic law: MODEL1310110027#
is: SBO:0000185
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reversible: false
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
fast: false

http://identifiers.org/biomodels.db/MODEL1310110027#_950220b7_43c1_4621_8f56_5914586ffe94
is encoded by: hsa:219
initial amount: NaN
is: P30837
has only substance units: false
type: Species
name: ALDH1B1
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

metaR UMPK7
type: Reaction
product: MODEL1310110027#
name: UMP kinase (dGTP)
reversible: true
kinetic law: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
modifier: MODEL1310110027#
is: SBO:0000176

metaR ACETONEt2
is: SBO:0000185
type: Reaction
name: acetone transport via proton symport
is described by: ECO:0000269
product: MODEL1310110027#
kinetic law: MODEL1310110027#
reversible: true
modifier: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
fast: false

metaR SCP22x
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.3.1.176
reversible: true
name: Sterol carrier protein 2
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
is: SBO:0000185
reactant: MODEL1310110027#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110027#_2c4ff21c_f5a5_4326_b00e_95d195e9b58c
initial concentration: NaN
type: Species
name: AMY2B
is: P19961
boundary condition: true
initial amount: NaN
is encoded by: hsa:280
is: SBO:0000252
constant: false
has only substance units: false

metaM nadp c
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: C00006
is: HMDB00217
is: CHEBI:58349
is: SBO:0000247
name: Nicotinamide adenine dinucleotide phosphate
constant: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
type: Species

metaM pe hs r
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
name: phosphatidylethanolamine
is: SBO:0000247
is: CHEBI:16038
type: Species
initial concentration: 1.0
constant: false

metaR FRUt4
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
modifier: MODEL1310110027#
is: SBO:0000185
reversible: true
product: MODEL1310110027#
reactant: MODEL1310110027#
fast: false
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110027#
name: D-fructose transport via sodium cotransport

metaR r0940
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
is: SBO:0000185
name: Free diffusion
product: MODEL1310110027#
is described by: ECO:0000000
kinetic law: MODEL1310110027#
fast: false
type: Reaction

metaR PAFH
name: Platelet-activating factor acetylhydrolase
reactant: MODEL1310110027#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.1.47
fast: false
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110027#
product: MODEL1310110027#
modifier: MODEL1310110027#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5051.1) or (5049.1 and 5050.1) or (5049.1 and 5050.1 and 5048.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.47 Confidence Level: 4 AUTHORS: PMID:7669037,PMID:8028668,PMID:8955149 NOTES:NJ

metaR GBA
product: MODEL1310110027#
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.2.1.45
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (2629.2) or (2629.3) or (2629.4) or (2629.5) or (2629.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 0 AUTHORS: PMID:15982918 NOTES:NJ
name: Glucosylceramidase
type: Reaction
reversible: false
is described by: ECO:0000000
fast: false
is: SBO:0000176
reactant: MODEL1310110027#

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

metaR r0488
kinetic law: MODEL1310110027#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reactant: MODEL1310110027#
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34
reversible: true
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:
fast: false

metaR ILELAT1tc
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Isoleucine by LAT1 in association with 4F2hc, across the apical surface of the memebranes.
type: Reaction

metaR r1497
kinetic law: MODEL1310110027#
reversible: false
name: Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter TCDB:2.A.28.1.1
type: Reaction
product: MODEL1310110027#
fast: false
is: SBO:0000185
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076396,PMID:11819755,PMID:17404808,PMID:6384004 NOTES:
is described by: ECO:0000000

metaM sebacid x
boundary condition: false
is: SBO:0000247
constant: false
name: sebacicacid
is: C08277
is: HMDB00792
notes: FORMULA: C10H16O4 CHARGE: -2
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR r0403
fast: false
is version of: http://identifiers.org/ec-code/1.2.4.4
is described by: ECO:0000000
product: MODEL1310110027#
reversible: true
type: Reaction
reactant: MODEL1310110027#
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
is: SBO:0000176
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.4 Confidence Level: 0 AUTHORS: NOTES:
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) Tryptophan metabolism EC:1.14.16.4

metaR BDHm
reversible: true
product: MODEL1310110027#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.30
modifier: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
kinetic law: MODEL1310110027#
fast: false
type: Reaction

metaR SEBACACT
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of sebacic acidd
type: Reaction

metaR GLCt1r
kinetic law: MODEL1310110027#
reversible: true
fast: false
modifier: MODEL1310110027#
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110027#
name: glucose transport (uniport)
reactant: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (66035.1) or (6517.1) or (56606.1) or (154091.1) or (6513.1) or (11182.1) or (29988.1) or (6514.1) or (155184.1) or (56606.2) or (144195.1) or (6515.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860667,PMID:10860996,PMID:10970791,PMID:11247674,PMID:11583593,PMID:11592815,PMID:11780753,PMID:11832379,PMID:11882499,PMID:12135767,PMID:12483288,PMID:12504846,PMID:12750891,PMID:12914765,PMID:14739288,PMID:15033637,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:

metaM CE0713 m
boundary condition: false
type: Species
initial concentration: 1.0
name: 3-oxolinoleoyl-CoA
initial amount: NaN
has only substance units: false
is: CHEBI:30623
is: HMDB02329
constant: false
is: SBO:0000247
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713

http://identifiers.org/biomodels.db/MODEL1310110027#_cdfa8fa2_474c_4823_a7f5_febb871d9927
name: _AI191472_1_c
has only substance units: false
boundary condition: true
is encoded by: hsa:AI191472
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species

metaM 3hpp m
is: SBO:0000247
initial concentration: 1.0
name: 3-hydroxypropionate
has only substance units: false
is: CHEBI:16510
type: Species
is: HMDB00700
constant: false
initial amount: NaN
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
boundary condition: false

metaR UMPK6
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
is described by: ECO:0000269
name: UMP kinase (dCTP)
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110027#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_f10c7dda_35af_4c1a_9c06_38264aa9d2e6
is: Q92685
has only substance units: false
is: SBO:0000252
name: ALG3
boundary condition: true
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:10195
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_dc9715b3_c4e4_4eeb_883c_c9ff319d33ad
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:275
type: Species
initial amount: NaN
boundary condition: true
name: AMT
is: P48728

metaR FPGS5m
reactant: MODEL1310110027#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT
product: MODEL1310110027#
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
name: folylpolyglutamate synthetase (DHF), mitochondrial
fast: false
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/6.3.2.17

http://identifiers.org/biomodels.db/MODEL1310110027#_cf052284_f942_440c_bb2d_e286f63d384f
name: _AI934540_1_c
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AI934540
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
constant: false

metaM hdcea r
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C16H29O2 CHARGE: -1 INCHI: InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7- HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
initial concentration: 1.0
is: HMDB03229
type: Species
name: palmitoleate
is: CHEBI:32372

metaR SPMTDe
reversible: true
is: SBO:0000185
product: MODEL1310110027#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
name: SPMTDe
type: Reaction
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#

metaR DM anth
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

metaM glc D e
is: SBO:0000247
name: D-glucose
constant: false
initial amount: NaN
is: CHEBI:4167
initial concentration: 1.0
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: HMDB00122
boundary condition: false
has only substance units: false

metaM lac L e
is: SBO:0000247
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
type: Species
is: CHEBI:16651
name: (S)-lactate
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
is: HMDB00190
has only substance units: false

metaM q10 c
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
has only substance units: false
type: Species
name: ubiquinone-10
initial concentration: 1.0
is: HMDB01072
initial amount: NaN
is: CHEBI:46245

http://identifiers.org/biomodels.db/MODEL1310110027#_c4cfe1f8_a5d1_421a_86af_c01f4c3414ef
is: Q9UF12
initial amount: NaN
is encoded by: hsa:58510
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
name: PRODH2

metaM ksi g
name: keratan sulfate I
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
has only substance units: false
is: SBO:0000247
is: CHEBI:57255
constant: false
boundary condition: false
initial amount: NaN
is: HMDB01014
initial concentration: 1.0
type: Species

metaM ak2lgchol hs e
initial concentration: 1.0
name: 1-alkyl 2-lysoglycerol 3-phosphocholine
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/6975
boundary condition: false
type: Species
is: C04317

metaM CE2421 m
initial concentration: 1.0
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
type: Species
is: CHEBI:30623
name: (3S)-3-hydroxylinoleoyl-CoA
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB02329

metaR r1862
modifier: MODEL1310110027#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
reversible: false
is described by: ECO:0000000
product: MODEL1310110027#
type: Reaction

metaM btcoa x
type: Species
is: HMDB01088
is: C00136
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C25H38N7O17P3S CHARGE: -4
name: Butanoyl-CoA
initial concentration: 1.0

metaM leuktrF4 c
initial concentration: 1.0
name: leukotriene F4
is: HMDB06465
is: CHEBI:27491
has only substance units: false
constant: false
type: Species
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaM accoa m
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: C00024
name: Acetyl-CoA
is: CHEBI:57288
is: HMDB01206

metaR S6T16g
reversible: false
is: SBO:0000176
type: Reaction
product: MODEL1310110027#
is described by: ECO:0000000
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
fast: false
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110027#_1e9216cf_0d95_4a42_8ba4_38a91eb3b80e
name: _AI972237_1_c
is: SBO:0000252
type: Species
is encoded by: hsa:AI972237
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN

metaR RE1448N
type: Reaction
is described by: ECO:0000000
fast: false
name: RE1448
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
product: MODEL1310110027#
kinetic law: MODEL1310110027#
reversible: true
reactant: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_1762c739_0956_4da3_8759_ec90400e44b6
constant: false
has only substance units: false
name: ST3GAL3
type: Species
initial amount: NaN
is encoded by: hsa:6487
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaM hmgcoa m
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
initial concentration: 1.0
is: SBO:0000247
name: Hydroxymethylglutaryl-CoA
is: CHEBI:15467
has only substance units: false
is: HMDB01375
boundary condition: false
initial amount: NaN
type: Species
constant: false

metaM m6masnC g
constant: false
initial amount: NaN
notes: FORMULA: C58H97N2O45X CHARGE: 0
boundary condition: false
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
type: Species
is: HMDB01356
is: CHEBI:57312
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaR DOPAt4 2 r
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
name: Dopamine reversible transport in via sodium symport (1:2)
is described by: ECO:0000269
product: MODEL1310110027#
fast: false
kinetic law: MODEL1310110027#
is: SBO:0000185
modifier: MODEL1310110027#
reactant: MODEL1310110027#
reversible: true
type: Reaction

metaR UMPK5
is described by: ECO:0000269
product: MODEL1310110027#
reversible: true
name: UMP kinase (dATP)
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
modifier: MODEL1310110027#
reactant: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_e6f8f956_5350_4965_b9f3_019c8445ceee
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:U37519
name: _U37519_1_m
boundary condition: true
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_c1d6925f_0cdd_4d9d_b638_3c89d5af310a
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:122970
initial concentration: NaN
is: SBO:0000252
is: Q8N9L9
name: ACOT4

metaM 7thf e
notes: FORMULA: C49H57N13O24 CHARGE: -8
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB06559
name: heptaglutamyl folate (THF)

metaM triodthy c
type: Species
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
initial concentration: 1.0
is: HMDB00265
is: SBO:0000247
has only substance units: false
name: 3,3',5-triiodo-L-thyronine
is: CHEBI:18258
initial amount: NaN
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_3e150b5b_edf9_44fe_8e06_9b14ed1c8f55
boundary condition: true
has only substance units: false
name: PI4KA
is encoded by: hsa:5297
is: SBO:0000252
initial concentration: NaN
constant: false
is: B4DYG5
initial amount: NaN
type: Species

metaR r0942
kinetic law: MODEL1310110027#
is: SBO:0000185
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:
reversible: true
is described by: ECO:0000000
product: MODEL1310110027#
type: Reaction
fast: false
reactant: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_d3c05d29_15a9_4144_be02_d77d70eea4a6
name: ALDH3B1
is encoded by: hsa:221
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is: P43353
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_b9748637_5e22_4351_a963_893d16d81531
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:6817
type: Species
name: SULT1A1
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM gdpfuc g
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
boundary condition: false
is: HMDB01095
has only substance units: false
is: SBO:0000247
constant: false
name: GDP-L-fucose(2-)
initial amount: NaN
type: Species
is: CHEBI:57984
initial concentration: 1.0

metaM m5masnC g
has only substance units: false
notes: FORMULA: C52H87N2O40X CHARGE: 0
boundary condition: false
initial amount: NaN
is: HMDB02985
constant: false
type: Species
is: SBO:0000247
is: CHEBI:58433
initial concentration: 1.0
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)

metaR CHATn
fast: false
modifier: MODEL1310110027#
reactant: MODEL1310110027#
name: Choline O-acetyltransferase
is version of: http://identifiers.org/ec-code/2.3.1.6
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
is: SBO:0000176
reversible: true
product: MODEL1310110027#
kinetic law: MODEL1310110027#

metaR r1418
reactant: MODEL1310110027#
reversible: true
fast: false
product: MODEL1310110027#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
type: Reaction
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
kinetic law: MODEL1310110027#

metaR CYSGLYexR
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
is described by: ECO:0000000
modifier: MODEL1310110027#
type: Reaction
name: L-cysteine/glycine reversible exchanger
fast: false
reversible: true
kinetic law: MODEL1310110027#
is: SBO:0000185
product: MODEL1310110027#
reactant: MODEL1310110027#

metaR UMPK4
is: SBO:0000176
type: Reaction
product: MODEL1310110027#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: UMP kinase (GTP)
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
is described by: ECO:0000269

metaR HMGCOASim
is version of: http://identifiers.org/ec-code/2.3.3.10
reversible: false
fast: false
product: MODEL1310110027#
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
name: Hydroxymethylglutaryl CoA synthase (ir)
type: Reaction

metaR DOLPMT1 Ler
notes: GENE_ASSOCIATION: (10195.4) or (10195.1) or (10195.3) or (10195.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
reactant: MODEL1310110027#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.258
fast: false
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110027#
product: MODEL1310110027#
is: SBO:0000176
modifier: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_9d6e7ea6_6279_4937_81d1_c76000b6969e
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:U37519
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
name: _U37519_1_e

metaR FAOXC225C204m
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)m
type: Reaction

metaM eitetcoa m
type: Species
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
constant: false
initial concentration: 1.0
is: HMDB02288
name: 5,8,11,14-eicosatetraenoylcoa
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false

metaM cholcoa c
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01374
is: CHEBI:57373
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
constant: false
name: choloyl-CoA(4-)
is: SBO:0000247
type: Species
boundary condition: false

metaR r2507
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
name: Utilized transport
is described by: ECO:0000000
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
is: SBO:0000185
type: Reaction
reversible: true
fast: false
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_6a474922_ce94_4f03_b4fb_524bdaa78439
initial concentration: NaN
name: DCTD
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:1635
is: P32321
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110027#_5f2f261e_d935_4441_b7ac_3038fa6db172
is encoded by: hsa:AU149534
initial concentration: NaN
is: SBO:0000252
name: _AU149534_1_e
initial amount: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true

metaR CORE4GTg
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9245.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.148 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
name: Core 4 beta6-GalNAc-transferase, Golgi apparatus
product: MODEL1310110027#
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.4.1.102
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
is: SBO:0000176
fast: false
reversible: false

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

metaR r1622
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110027#
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
reactant: MODEL1310110027#
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_90ccb521_50f2_4822_827e_351bd6f3a6b6
has only substance units: false
name: ACAA1
initial amount: NaN
is: Q96CA6
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:30
constant: false

metaM 2decdicoa m
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: 2,7-decadienoylcoa
type: Species
is: http://identifiers.org/pubchem.compound/16019966

metaR SUCCTD
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

metaR GGH 6DHFl
fast: false
is described by: ECO:0000000
product: MODEL1310110027#
name: Gamma-glutamyl hydrolase (6DHF), lysosomal
kinetic law: MODEL1310110027#
type: Reaction
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.4.19.9
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110027#_959a69b6_2449_4ed9_a117_6bc736038900
is encoded by: hsa:4709
name: NDUFB3
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q6IB80
has only substance units: false
is: SBO:0000252
constant: false

metaR r2379
reactant: MODEL1310110027#
fast: false
product: MODEL1310110027#
type: Reaction
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110027#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110027#_fc9d9209_aef2_4bce_b16d_35be65eae8b8
is: SBO:0000252
name: _AI640625_1_c
initial amount: NaN
type: Species
is encoded by: hsa:AI640625
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_964f40db_64e9_4ed6_a66d_b3fd1a19bfdf
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
is: P51648
boundary condition: true
type: Species
initial concentration: NaN
name: ALDH3A2
is encoded by: hsa:224

metaR r1116
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110027#
reversible: true
is: SBO:0000185
reactant: MODEL1310110027#

metaM glc D c
type: Species
name: D-glucose
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
has only substance units: false
is: HMDB00122
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:4167

metaR NDPK9
reactant: MODEL1310110027#
fast: false
kinetic law: MODEL1310110027#
name: nucleoside-diphosphate kinase (ATP:IDP)
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
reversible: true
is described by: ECO:0000269
product: MODEL1310110027#
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110027#_318846a7_11ed_4f87_a6a6_6c382259f42f
constant: false
is: P30084
type: Species
is encoded by: hsa:1892
name: ECHS1
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_2b0607a2_7b3e_4490_9bcc_de7cd080dd7a
initial amount: NaN
has only substance units: false
is encoded by: hsa:8704
is: SBO:0000252
is: O60909
type: Species
name: B4GALT2
boundary condition: true
constant: false
initial concentration: NaN

metaR r2506
is described by: ECO:0000000
reactant: MODEL1310110027#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
name: Utilized transport
type: Reaction
product: MODEL1310110027#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110027#

metaR RE3624M
is: SBO:0000176
reversible: false
fast: false
kinetic law: MODEL1310110027#
is described by: ECO:0000000
reactant: MODEL1310110027#
modifier: MODEL1310110027#
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.3.3.6
name: RE3624
type: Reaction
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:

metaR r0944
product: MODEL1310110027#
is: SBO:0000185
name: Active transport
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#

metaR HIBDm
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
kinetic law: MODEL1310110027#
is described by: ECO:0000269
product: MODEL1310110027#
fast: false
reversible: true
type: Reaction
is: SBO:0000176
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
is version of: http://identifiers.org/ec-code/1.1.1.31
reactant: MODEL1310110027#
modifier: MODEL1310110027#

metaM 10fthf c
has only substance units: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
name: 10-Formyltetrahydrofolate
is: C00234
initial concentration: 1.0
boundary condition: false
is: CHEBI:57454
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB00972

metaR r1621
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110027#
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110027#
kinetic law: MODEL1310110027#

metaM HC01712 m
constant: false
initial concentration: 1.0
is: CHEBI:28391
type: Species
notes: FORMULA: C13H22NO4S2 CHARGE: -1 INCHI: InChI=1S/C13H23NO4S2/c14-11(15)5-2-1-4-10(19)8-9-20-13(18)7-3-6-12(16)17/h10,19H,1-9H2,(H2,14,15)(H,16,17) EHMN_ABBREVIATION: C06157
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: S-Glutaryldihydrolipoamide
has only substance units: false

metaR RE0452M
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000000
product: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.9 Confidence Level: 0 AUTHORS: PMID:8024690 NOTES:
is: SBO:0000176
reversible: true
name: RE0452
type: Reaction

metaM pi g
is: CHEBI:43474
constant: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
boundary condition: false
type: Species
initial amount: NaN
is: HMDB00973
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: hydrogenphosphate

metaR r1964
is described by: ECO:0000000
reactant: MODEL1310110027#
modifier: MODEL1310110027#
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110027#
is: SBO:0000185
reversible: false
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_debf0112_92c9_41e3_876a_8cf32b4c9e3f
initial amount: NaN
is: P07686
has only substance units: false
boundary condition: true
initial concentration: NaN
name: HEXB
type: Species
is: SBO:0000252
is encoded by: hsa:3074
constant: false

metaR DAGK hs
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110027#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.107
modifier: MODEL1310110027#
product: MODEL1310110027#
is: SBO:0000176
fast: false
name: Diacylglycerol phosphate kinase (homo sapiens)
reversible: true
kinetic law: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_19cb72e4_ac92_4b70_a710_dc9cda2a83fe
name: GCDH
boundary condition: true
is encoded by: hsa:2639
is: Q92947
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_350b8af2_1617_44a4_9c8d_8540785cb601
type: Species
is: O00142
boundary condition: true
constant: false
name: TK2
initial concentration: NaN
has only substance units: false
is encoded by: hsa:7084
initial amount: NaN
is: SBO:0000252

metaM 3mb2coa m
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069
constant: false
is: SBO:0000247
boundary condition: false
name: 3-methylbut-2-enoyl-CoA(4-)
type: Species
has only substance units: false
is: CHEBI:57344
is: HMDB01493

http://identifiers.org/biomodels.db/MODEL1310110027#_568818be_41dc_44a9_9920_2cb7f77d5c33
constant: false
has only substance units: false
is: O43837
initial amount: NaN
is encoded by: hsa:3420
name: IDH3B
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true

metaR r2378
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110027#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false
reactant: MODEL1310110027#
is: SBO:0000185
product: MODEL1310110027#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_43e2a92d_9d5d_4b21_82ca_5f1f5728a467
is encoded by: hsa:218
constant: false
initial concentration: NaN
has only substance units: false
type: Species
name: ALDH3A1
is: P30838
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR r1117
fast: false
name: Facilitated diffusion
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17124168 NOTES:
type: Reaction
product: MODEL1310110027#
reversible: true
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#

metaR ASNALANaEx
type: Reaction
kinetic law: MODEL1310110027#
fast: false
name: L-alanine/L-asparagine Na-dependent exchange (Asn-L in)
reversible: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000269
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110027#_74e2bbb4_2ba3_448c_8220_f2e073bf745a
is: Q9NT06
initial amount: NaN
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
name: HMGCLL1
is encoded by: hsa:54511
boundary condition: true

metaM 3hbcoa m
is: CHEBI:57316
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB01166
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
constant: false
boundary condition: false
name: (S)-3-hydroxybutanoyl-CoA(4-)
has only substance units: false

metaR NDPK8
is described by: ECO:0000269
reversible: true
name: Nucleoside-diphosphate kinase (ATP:dADP)
type: Reaction
fast: false
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110027#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110027#
reactant: MODEL1310110027#

metaR PAIL45P HStn
reversible: true
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
product: MODEL1310110027#
is described by: ECO:0000000
fast: false
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
is: SBO:0000185
type: Reaction
reactant: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_cb7f906c_b2a0_493c_adf9_37da55e839fc
has only substance units: false
is encoded by: hsa:AI926493
constant: false
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: _AI926493_1_m

metaM lnlccoa c
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
name: linoleic coenzyme A
is: http://identifiers.org/pubchem.compound/5462164
boundary condition: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
is: HMDB01064
is: SBO:0000247

metaR MCCCrm
name: methylcrotonoyl-CoA carboxylase, mitochondrial
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (56922.1 and 64087.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.4 Confidence Level: 4 AUTHORS: PMID:11181649,PMID:11406611 NOTES:MM
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.4.1.4
reactant: MODEL1310110027#
reversible: true
is described by: ECO:0000269
fast: false
product: MODEL1310110027#
type: Reaction
modifier: MODEL1310110027#

metaR DOPASFt
fast: false
is described by: ECO:0000000
reversible: false
name: Dopamine 3-0-sulfate transport (diffusion)
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of dopamine sulfate
type: Reaction
product: MODEL1310110027#
is: SBO:0000185

metaR GTHPe
is version of: http://identifiers.org/ec-code/1.11.1.9
fast: false
reactant: MODEL1310110027#
product: MODEL1310110027#
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110027#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (2878.1) or (257202.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:3619451 NOTES:SAB
name: glutathione peroxidase (e)

http://identifiers.org/biomodels.db/MODEL1310110027#_fe1c293b_9c14_4fd4_98a6_0ef3ca66d362
is: Q99519
boundary condition: true
type: Species
name: NEU1
is encoded by: hsa:4758
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_20c37c52_b77d_4f07_9ac8_74aa036c73ec
is: P52824
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
name: DGKQ
type: Species
is encoded by: hsa:1609
initial concentration: NaN
boundary condition: true

metaR PNTOt5le
is described by: ECO:0000134
name: Pantothenate sodium symporter II
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (8884.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: false
is: SBO:0000185
type: Reaction
modifier: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
fast: false

metaR r1624
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110027#
is: SBO:0000185
kinetic law: MODEL1310110027#
fast: false
modifier: MODEL1310110027#
is described by: ECO:0000000
reversible: true

metaM core2 g
name: Core 2
notes: FORMULA: C22H37N2O15X CHARGE: 0
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
is: CHEBI:15876
is: SBO:0000247
initial amount: NaN

metaR CYOR u10m
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.5.1.92
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
reactant: MODEL1310110027#
type: Reaction
name: ubiquinol-6 cytochrome c reductase, Complex III
kinetic law: MODEL1310110027#
fast: false
reversible: false
is: SBO:0000185
product: MODEL1310110027#

metaR r0590
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
fast: false
modifier: MODEL1310110027#
type: Reaction
is: SBO:0000176
product: MODEL1310110027#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
is version of: http://identifiers.org/ec-code/1.2.1.5

metaR TCHOLAte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reversible: true
product: MODEL1310110027#
name: bile acid intracellular transport
is described by: ECO:0000000
fast: false
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
is: SBO:0000185
type: Reaction

metaR RE1517M
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/1.3.99.13
fast: false
name: RE1517
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
is: SBO:0000176
reactant: MODEL1310110027#
type: Reaction
product: MODEL1310110027#

metaR DCTPtn
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
kinetic law: MODEL1310110027#
name: dCTP diffusion in nucleus
is: SBO:0000185
reactant: MODEL1310110027#
reversible: true
product: MODEL1310110027#

metaR EX idp LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IDP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_74ffe55b_8657_4c1f_a790_2eae40f1ee07
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:80055
is: Q75T13
name: PGAP1
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN

metaM hdcea l
initial amount: NaN
name: palmitoleate
has only substance units: false
notes: FORMULA: C16H29O2 CHARGE: -1 INCHI: InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7- HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
type: Species
initial concentration: 1.0
is: HMDB03229
constant: false
is: CHEBI:32372
is: SBO:0000247
boundary condition: false

metaR r0946
product: MODEL1310110027#
is: SBO:0000185
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110027#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM dlnlcgcoa c
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:27979
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
type: Species
constant: false
name: dihomo-gamma-linolenyl coenzyme A
boundary condition: false
has only substance units: false

metaR NDPK7
kinetic law: MODEL1310110027#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110027#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110027#
product: MODEL1310110027#
is described by: ECO:0000269
name: nucleoside-diphosphate kinase (ATP:dCDP)

metaM accoa x
name: Acetyl-CoA
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
constant: false
is: CHEBI:57288
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01206
is: C00024
boundary condition: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_4c0d374f_2d1b_4507_ad9e_60e7a8d3625c
boundary condition: true
initial amount: NaN
constant: false
is: P51553
initial concentration: NaN
has only substance units: false
is encoded by: hsa:3421
type: Species
name: IDH3G
is: SBO:0000252

metaM strdnccoa c
is: http://identifiers.org/pubchem.compound/47205473
initial amount: NaN
name: stearidonyl coenzyme A
is: HMDB06519
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
has only substance units: false
boundary condition: false
is: C16163
type: Species
constant: false

metaR r1966
name: Y+LAT2 Utilized transport
reversible: false
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110027#
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
is described by: ECO:0000000
product: MODEL1310110027#

metaM ksi pre11 g
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
type: Species
name: keratan sulfate I biosynthesis, precursor 11
is: CHEBI:28067
notes: FORMULA: C129H208N9O101S3X CHARGE: -4
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_4ecd7ad5_031c_4c4e_93b6_31feb1e1c26c
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: AK2
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:204

metaR PNTK
product: MODEL1310110027#
kinetic law: MODEL1310110027#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.33
reversible: false
name: pantothenate kinase
fast: false
modifier: MODEL1310110027#
is described by: ECO:0000269
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (79646.1) or (80025.2) or (53354.1) or (53354.3) or (80025.1) or (53354.2) or (80025.3) or (80025.4) or (55229.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction

metaR MGCHrm
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.18
reactant: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#
reversible: true
modifier: MODEL1310110027#
name: methylglutaconyl-CoA hydratase (reversible), mitochondrial
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (549.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.18 Confidence Level: 4 AUTHORS: PMID:12434311,PMID:3082934 NOTES:MM
is described by: ECO:0000269
is: SBO:0000176

metaM thyox L c
is: HMDB00248
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
name: L-thyroxine
is: CHEBI:18332
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_f10e74ff_93f8_4420_b34c_147abca027a5
boundary condition: true
name: PIGT
type: Species
is: Q969N2
constant: false
initial concentration: NaN
is encoded by: hsa:51604
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR ALCD2yf
is described by: ECO:0000134
product: MODEL1310110027#
modifier: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (10327.1) or (10327.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:11003211,PMID:14576493,PMID:19382904,PMID:19382905 NOTES:NCD
kinetic law: MODEL1310110027#
fast: false
is: SBO:0000176
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.1.1.2
reversible: false
name: alcohol dehydrogenase (ethanol, NADP), forward reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_2b04b0e8_4a01_4fe5_9fe1_a2c0d3559aa6
is: SBO:0000252
is encoded by: hsa:29925
constant: false
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: GMPPB

metaR r1623
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
fast: false
modifier: MODEL1310110027#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110027#
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#

metaR DOLDPP Ler
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
fast: false
modifier: MODEL1310110027#
reversible: false
name: Dolichyl-diphosphate phosphohydrolase, human (liver)
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.1.43
notes: GENE_ASSOCIATION: (57171.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.6.1.43 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:NCD
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110027#_0a7719a4_ecdb_4cf0_a525_6db175899c79
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:51
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: B4DK61
type: Species
name: ACOX1

metaR EX dca LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Decanoate (n-C10:0) exchange
type: Reaction

metaR r0591
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
product: MODEL1310110027#
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
is described by: ECO:0000000
fast: false
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#

metaM 3oddcoa x
type: Species
name: 3-Oxododecanoyl-CoA
initial concentration: 1.0
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
initial amount: NaN
is: CHEBI:27868
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
is: HMDB03937

metaR GNMT
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (27232.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.1.20 Confidence Level: 4 AUTHORS: PMID:10843803,PMID:11810299 NOTES:
is described by: ECO:0000269
type: Reaction
product: MODEL1310110027#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.1.1.20
reactant: MODEL1310110027#
name: glycine N-methyltransferase
fast: false

metaM etoh e
is: CHEBI:16236
is: SBO:0000247
boundary condition: false
has only substance units: false
name: ethanol
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
initial amount: NaN
is: HMDB00108

metaR FAOXC101C8m
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C8)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_87b322cf_0aa1_4f0c_b2e3_6d272ed72dbd
is encoded by: hsa:55967
boundary condition: true
is: F8VQS7
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
name: NDUFA12

metaM dece3coa m
name: 3-decenoylcoa
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/16019966
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_573411c4_dc5d_42d2_9dc3_4d45929f7010
boundary condition: true
has only substance units: false
type: Species
name: _728637_1_c
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:728637
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_3ebeb721_de4b_4638_ba0b_e48af2dae156
is: P30084
name: ECHS1
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1892
boundary condition: true
constant: false
type: Species
initial amount: NaN
is: SBO:0000252

metaR AMPDA
is described by: ECO:0000269
is: SBO:0000176
name: Adenosine monophosphate deaminase
product: MODEL1310110027#
reversible: false
is version of: http://identifiers.org/ec-code/3.5.4.6
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (271.2) or (270.1) or (271.1) or (272.1) or (271.3) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.6 Confidence Level: 4 AUTHORS: PMID:1400401,PMID:2345176 NOTES:
fast: false
reactant: MODEL1310110027#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_a0c9a53d_8464_4237_a799_f43ed44b5c76
initial concentration: NaN
constant: false
type: Species
name: NDUFS7
boundary condition: true
is: O75251
is encoded by: hsa:374291
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR FAOXC227C226m
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:7-->C22:6)m
type: Reaction

metaR MTHFD
name: methylenetetrahydrofolate dehydrogenase (NADP)
modifier: MODEL1310110027#
reversible: true
reactant: MODEL1310110027#
is described by: ECO:0000134
type: Reaction
is: SBO:0000176
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (4522.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.5.1.5
fast: false

http://identifiers.org/biomodels.db/MODEL1310110027#_9445f263_aeb3_47b8_a620_5d2589a0d297
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:5298
initial amount: NaN
initial concentration: NaN
is: Q9UBF8
boundary condition: true
type: Species
name: PI4KB

metaR SIAASE4ly
is described by: ECO:0000000
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
reactant: MODEL1310110027#
name: sialidase, lysosomal
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110027#
type: Reaction
fast: false
modifier: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_f3820173_3c09_43e3_ac35_a43f5871d550
is: P47895
name: ALDH1A3
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:220
initial amount: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_9fdd3e9a_04fe_4795_9bd2_1a9a8e67d8e0
type: Species
is encoded by: hsa:T83654
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
name: _T83654_1_m
initial amount: NaN

metaR r2375
fast: false
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110027#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#
is described by: ECO:0000000

metaM thyox L e
is: HMDB00248
constant: false
has only substance units: false
is: CHEBI:18332
type: Species
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
initial amount: NaN
boundary condition: false
name: L-thyroxine
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110027#_bb2aa454_1b2e_413e_9c8f_4d8c009e050e
constant: false
is encoded by: hsa:81031
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
is: O95528
type: Species
name: SLC2A10
is: SBO:0000252

metaM g1p c
is: HMDB01586
initial concentration: 1.0
boundary condition: false
name: D-Glucose 1-phosphate
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
constant: false
is: C00103
is: CHEBI:58601

http://identifiers.org/biomodels.db/MODEL1310110027#_2d546396_4fe1_45a2_8a39_6ed118f6fb90
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: Q14749
is encoded by: hsa:27232
initial amount: NaN
type: Species
name: GNMT
boundary condition: true

metaR CREATt4 2 r
type: Reaction
modifier: MODEL1310110027#
product: MODEL1310110027#
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110027#
reversible: true
name: Creatine transport (sodium symport) (2:1)
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
fast: false
kinetic law: MODEL1310110027#

metaR 5MTHFt
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
is: SBO:0000185
reactant: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#
fast: false
product: MODEL1310110027#
is described by: ECO:0000269
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110027#_9d29c9a4_e7e6_4387_8326_5f9f83be2940
type: Species
initial concentration: NaN
boundary condition: true
is: Q9H6Y6
constant: false
is encoded by: hsa:4645
is: SBO:0000252
name: MYO5B
has only substance units: false
initial amount: NaN

metaM nadh m
is: http://identifiers.org/pubchem.compound/3306
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: Nicotinamide adenine dinucleotide - reduced
is: C00004
is: HMDB01487
initial amount: NaN
constant: false
type: Species
is: CHEBI:57945
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_84cbee09_4b96_4bc9_a45a_fd67f103feac
initial concentration: NaN
type: Species
is encoded by: hsa:55500
boundary condition: true
constant: false
name: ETNK1
is: Q9HBU6
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR DNDPt26m
reactant: MODEL1310110027#
is described by: ECO:0000269
fast: false
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110027#
name: dCDP transport via dUDP antiport
modifier: MODEL1310110027#
is: SBO:0000185
product: MODEL1310110027#

metaM btcoa m
is: CHEBI:57371
boundary condition: false
name: Butanoyl-CoA
is: SBO:0000247
is: HMDB01088
type: Species
has only substance units: false
constant: false
is: C00136
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
initial concentration: 1.0
initial amount: NaN

metaM core6 l
boundary condition: false
name: Core 6
is: CHEBI:12936
is: HMDB00143
initial amount: NaN
notes: FORMULA: C16H27N2O10X CHARGE: 0
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247

metaM glyc3p x
has only substance units: false
constant: false
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:57597
is: HMDB00126
boundary condition: false
name: Glycerol 3-phosphate
is: C00093

metaM CE4872 m
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
has only substance units: false
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15748
boundary condition: false
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
is: HMDB00127

metaR r0033
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.6.1.5
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110027#
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
is: SBO:0000176
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
reversible: false
product: MODEL1310110027#
modifier: MODEL1310110027#
fast: false

metaR RE1533M
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reactant: MODEL1310110027#
fast: false
kinetic law: MODEL1310110027#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
name: RE1533
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110027#

metaR r2374
type: Reaction
kinetic law: MODEL1310110027#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false
product: MODEL1310110027#

metaM pi c
is: C00009
name: hydrogenphosphate
constant: false
is: HMDB00973
type: Species
initial concentration: 1.0
is: CHEBI:43474
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: HO4P CHARGE: -2
initial amount: NaN

metaM duri c
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
type: Species
is: C00526
is: HMDB00012
is: CHEBI:16450
name: Deoxyuridine

http://identifiers.org/biomodels.db/MODEL1310110027#_06db8dcf_4894_4e47_bb54_35dd74b81dd5
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
name: SLC20A1
boundary condition: true
is: Q8WUM9
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6574

metaR C4tcx
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of bytyrylcarnitine from peroxisomes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_5d87a8ab_d529_4c6e_9b62_f51619287650
is encoded by: hsa:759
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
name: CA1
is: P00915
type: Species
initial concentration: NaN

metaR r1757
is: SBO:0000185
product: MODEL1310110027#
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: false
is described by: ECO:0000000
fast: false
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_50d728b9_fbd0_42be_bd01_d65916434fd0
is: SBO:0000252
has only substance units: false
is encoded by: hsa:50484
constant: false
initial concentration: NaN
boundary condition: true
is: Q7LG56
type: Species
initial amount: NaN
name: RRM2B

metaM etoh c
is: HMDB00108
is: CHEBI:16236
has only substance units: false
boundary condition: false
name: ethanol
is: SBO:0000247
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_b8a76937_cc09_4900_94ae_1936491502d0
initial amount: NaN
has part: Q9HCC0
type: Species
is: SBO:0000297
name: MCCC1:MCCC2
has part: Q96RQ3
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:64087
initial concentration: NaN
is encoded by: hsa:56922

metaR NACDe
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: release of nicotinate at the basolateral surface
type: Reaction

metaR CHOLESTle
reversible: false
kinetic law: MODEL1310110027#
fast: false
is: SBO:0000176
is described by: ECO:0000134
modifier: MODEL1310110027#
name: hydrolysis of cholesterol ester by cholesterol esterase
is version of: http://identifiers.org/ec-code/3.1.1.13
type: Reaction
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (3988.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110027#

metaM pristcoa x
constant: false
name: pristanoyl coa
type: Species
is: CHEBI:51341
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
is: SBO:0000247
boundary condition: false

metaR r2501
fast: false
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.3
is described by: ECO:0000000
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
product: MODEL1310110027#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:18619829 NOTES:
is: SBO:0000185

metaR r2377
reactant: MODEL1310110027#
is: SBO:0000185
product: MODEL1310110027#
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
kinetic law: MODEL1310110027#

metaR r1620
modifier: MODEL1310110027#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000000
is: SBO:0000185

metaR r0523
product: MODEL1310110027#
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
reversible: false
type: Reaction
fast: false
is described by: ECO:0000000
modifier: MODEL1310110027#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.17.4.1

metaR UDPGLCter
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
reversible: true
type: Reaction
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110027#
is: SBO:0000185

metaM amet c
initial concentration: 1.0
boundary condition: false
is: C00019
is: HMDB01185
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: CHEBI:15414
name: S-Adenosyl-L-methionine
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: SBO:0000247

metaM ditp c
constant: false
initial concentration: 1.0
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
has only substance units: false
is: HMDB03537
name: dITP(4-)
is: SBO:0000247
boundary condition: false
is: CHEBI:61382
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_3055fd1f_2bfd_4574_8741_18a8a2456fc5
is encoded by: hsa:8501
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
is: O75387
name: SLC43A1
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110027#_8371d0b8_edbd_4bfa_9a8b_9cdba1b3a6ae
boundary condition: true
type: Species
constant: false
is: O43677
has only substance units: false
initial amount: NaN
is encoded by: hsa:4717
name: NDUFC1
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110027#_fbba3eb5_cd7b_4d3a_b4d6_7ee22cc7dd41
is: SBO:0000252
name: MAN1C1
constant: false
is encoded by: hsa:57134
has only substance units: false
is: Q9NR34
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR S6T5g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110027#
type: Reaction
fast: false
is described by: ECO:0000000
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110027#
product: MODEL1310110027#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_553fe29e_42fc_43f0_9c7a_bcda560dee94
initial amount: NaN
is encoded by: hsa:3034
name: HAL
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
is: B4E0V8
has only substance units: false
type: Species

metaR MTHFC
notes: GENE_ASSOCIATION: (4522.1) or (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
name: methenyltetrahydrofolate cyclohydrolase
is described by: ECO:0000134
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/3.5.4.9
reactant: MODEL1310110027#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.5.1.5
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_1906e887_02a5_4e3f_a65d_c0f28336e481
is encoded by: hsa:AI971036
name: _AI971036_1_c
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
constant: false
initial concentration: NaN

metaR PI5P3K
kinetic law: MODEL1310110027#
name: phosphatidylinositol-5-phosphate 3-kinase
product: MODEL1310110027#
fast: false
is version of: http://identifiers.org/ec-code/2.7.11.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5295.2 and 5290.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.1) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5290.1 and 5295.3) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
type: Reaction
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.1.154
is version of: http://identifiers.org/ec-code/2.7.1.153
is: SBO:0000176
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.1.137
reversible: false

metaR r2376
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
kinetic law: MODEL1310110027#
fast: false
reactant: MODEL1310110027#
product: MODEL1310110027#
is: SBO:0000185
type: Reaction
reversible: true

metaR FAOXC10C8x
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->C8)x
type: Reaction

metaR KYN3OX
is: SBO:0000176
reactant: MODEL1310110027#
name: kynurenine 3-monooxygenase
is version of: http://identifiers.org/ec-code/1.14.13.9
product: MODEL1310110027#
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (8564.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.13.9 Confidence Level: 4 AUTHORS: PMID:9237672 NOTES:NCD
fast: false
is described by: ECO:0000269
modifier: MODEL1310110027#
reversible: false
type: Reaction

metaR r1756
name: Y+LAT2 Utilized transport
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
reversible: false
modifier: MODEL1310110027#
product: MODEL1310110027#
is: SBO:0000185
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r0377
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
type: Reaction
is: SBO:0000176
reversible: false
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.3
product: MODEL1310110027#
fast: false
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110027#_2a224d25_3818_4b73_a5eb_4b39e94b1d43
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
is: Q02218
type: Species
name: OGDH
boundary condition: true
is encoded by: hsa:4967
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_866895b7_c4eb_467b_ab6a_8c185bfd2657
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: SLC22A5
is encoded by: hsa:6584
constant: false
is: O76082
type: Species

metaR r0522
modifier: MODEL1310110027#
fast: false
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
type: Reaction
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
reversible: false
is described by: ECO:0000000
product: MODEL1310110027#
is: SBO:0000176

metaM HC00229 e
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
has only substance units: false
name: Isomaltose
is: CHEBI:28189

metaM pi e
boundary condition: false
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: C00009
constant: false
is: CHEBI:43474
initial concentration: 1.0
has only substance units: false
is: HMDB00973
name: hydrogenphosphate
is: SBO:0000247
type: Species
initial amount: NaN

metaR MANt4
modifier: MODEL1310110027#
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
type: Reaction
product: MODEL1310110027#
fast: false
name: D-mannose transport via sodium cotransport
kinetic law: MODEL1310110027#
reversible: true
reactant: MODEL1310110027#

metaM 3mob m
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
is: SBO:0000247
constant: false
name: 3-methyl-2-oxobutanoate
is: CHEBI:11851
boundary condition: false
is: HMDB00019
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN

metaM 4mop c
is: CHEBI:17865
has only substance units: false
is: HMDB00695
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: 4-methyl-2-oxopentanoate
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233

metaM txa2 r
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
name: thromboxane A2(1-)
type: Species
is: CHEBI:57445
initial concentration: 1.0
is: HMDB01452

http://identifiers.org/biomodels.db/MODEL1310110027#_76a6e1eb_33e8_47d8_9a23_c7792be8c523
has only substance units: false
is encoded by: hsa:2686
is: SBO:0000252
constant: false
initial amount: NaN
name: GGT7
is: A0PJJ9
initial concentration: NaN
type: Species
boundary condition: true

metaR EX s2l2n2m2masn LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: de-Fuc form of PA6 exchange
type: Reaction

metaM amp e
type: Species
constant: false
name: AMP
has only substance units: false
is: C00020
initial amount: NaN
boundary condition: false
is: HMDB00045
is: SBO:0000247
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: CHEBI:456215
initial concentration: 1.0

metaM hdcea e
initial concentration: 1.0
is: CHEBI:32372
initial amount: NaN
name: Hexadecenoate (n-C16:1)
constant: false
is: HMDB03229
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR r0502
is version of: http://identifiers.org/ec-code/2.7.1.113
type: Reaction
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
kinetic law: MODEL1310110027#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110027#
product: MODEL1310110027#
modifier: MODEL1310110027#

metaM duri e
boundary condition: false
is: C00526
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: CHEBI:16450
is: HMDB00012
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
name: Deoxyuridine
constant: false
is: SBO:0000247

metaR r0385
fast: false
reversible: false
reactant: MODEL1310110027#
is described by: ECO:0000000
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110027#
name: 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

metaR G14T12g
type: Reaction
modifier: MODEL1310110027#
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110027#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
product: MODEL1310110027#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110027#_8fc3acdf_98c4_401a_a0e5_e80d765b7734
name: MTHFD2L
boundary condition: true
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is: Q9H903
is encoded by: hsa:441024
initial amount: NaN
is: SBO:0000252

metaR LNLNCAt
fast: false
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
product: MODEL1310110027#
kinetic law: MODEL1310110027#
reversible: true
reactant: MODEL1310110027#

metaR TYMSFt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of tyramine sulfate
is: SBO:0000185
reversible: false
name: Tyramine O-sulfate transport (diffusion)
fast: false
is described by: ECO:0000000
product: MODEL1310110027#
reactant: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#

metaM nm2masn g
has only substance units: false
type: Species
constant: false
boundary condition: false
notes: FORMULA: C42H70N3O30X CHARGE: 0
is: C05884
initial amount: NaN
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
initial concentration: 1.0
is: SBO:0000247

metaM 2oxoadp m
is: HMDB00225
is: CHEBI:57499
has only substance units: false
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: 2-oxoadipate(2-)
initial amount: NaN
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322

metaR AMETtd
kinetic law: MODEL1310110027#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110027#
name: diffusion of S-Adenosyl-L-methionine
reversible: true
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110027#
fast: false

metaR PPItx
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is: SBO:0000185
kinetic law: MODEL1310110027#
name: Diphosphate transporter, peroxisome
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_21fdf847_d7ae_49c5_a3bf_895699b16f4b
is: P24310
is encoded by: hsa:1346
name: COX7A1
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species

metaR r0384
reactant: MODEL1310110027#
is described by: ECO:0000000
kinetic law: MODEL1310110027#
type: Reaction
is: SBO:0000176
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
name: 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2
reversible: false
fast: false

metaM nadh r
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
is: CHEBI:57945
is: HMDB01487
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: NADH(2-)
has only substance units: false

metaM cit c
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
initial concentration: 1.0
is: CHEBI:16947
is: SBO:0000247
boundary condition: false
is: C00158
name: Citrate
has only substance units: false
constant: false
type: Species
is: HMDB00094
initial amount: NaN

metaR PAPStg
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
is described by: ECO:0000269
name: 3'-Phosphoadenylyl sufate Golgi transport
fast: false
type: Reaction
kinetic law: MODEL1310110027#
product: MODEL1310110027#
is: SBO:0000185
modifier: MODEL1310110027#
reactant: MODEL1310110027#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110027#_1aa7e3c4_378b_4dfc_a7f5_6d7913fe0031
is: SBO:0000252
type: Species
constant: false
name: UCKL1
is encoded by: hsa:54963
is: Q53HM1
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_8c42587b_7744_4cc5_8139_6e7574befafe
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:9962
constant: false
name: SLC23A2
type: Species
initial concentration: NaN
is: Q9UGH3

http://identifiers.org/biomodels.db/MODEL1310110027#_202943c9_5c21_42f9_8f36_6f84dafac76b
initial concentration: NaN
boundary condition: true
name: DPM1
is: O60762
is encoded by: hsa:8813
type: Species
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN

metaM spc hs e
type: Species
is: http://identifiers.org/pubchem.compound/5311445
name: sphingosylphosphorylcholine
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaM gtp c
initial concentration: 1.0
is: HMDB01273
is: SBO:0000247
type: Species
constant: false
has only substance units: false
name: GTP
initial amount: NaN
is: C00044
is: CHEBI:37565
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
boundary condition: false

metaM nrpphrsf c
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/123747
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
initial concentration: 1.0
name: Sulfate derivative of norepinephrine
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB02062
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_b2be1e74_cb16_4826_9420_6440dfc0eb3a
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
name: TKTL2
constant: false
is encoded by: hsa:84076
is: Q9H0I9
initial amount: NaN
initial concentration: NaN

metaM dhea c
boundary condition: false
constant: false
is: HMDB00077
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C01227
type: Species
initial amount: NaN
name: 3beta-hydroxyandrost-5-en-17-one
initial concentration: 1.0
is: CHEBI:28689
has only substance units: false
is: SBO:0000247

metaM sql r
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
is: CHEBI:15440
name: squalene
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB00256

metaM dnad c
boundary condition: false
is: SBO:0000247
name: Deamino-NAD+
constant: false
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
initial amount: NaN
type: Species
is: C00857
is: HMDB01179
initial concentration: 1.0
has only substance units: false
is: CHEBI:18304

metaR EX co LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Carbon monoxide exchange
type: Reaction

metaR RE1845X
product: MODEL1310110027#
type: Reaction
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.3.1.65
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 1 h[c] from compEHMN reaction as they were not necessary
name: RE1845
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110027#
reversible: true
modifier: MODEL1310110027#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110027#_8f7fea72_9e1e_4564_9c01_cdb2db6545af
is encoded by: hsa:51727
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is: B2R6S5
type: Species
constant: false
name: CMPK1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_daf7db81_c547_4092_9e61_da978ca8059b
type: Species
boundary condition: true
name: _7359_1_c
constant: false
initial amount: NaN
is encoded by: hsa:7359
has only substance units: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110027#_b2f950b2_c36f_4ea7_bada_426814655caa
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:2181
has only substance units: false
name: ACSL3
boundary condition: true
is: O95573
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_7d024393_58f0_4eb1_9547_5e07ee0d5d9a
initial concentration: NaN
initial amount: NaN
is: Q9H310
has only substance units: false
type: Species
constant: false
boundary condition: true
is encoded by: hsa:57127
name: RHBG
is: SBO:0000252

metaR r0170
product: MODEL1310110027#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
fast: false
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.1.40
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
reversible: true
modifier: MODEL1310110027#

metaR RE2814M
name: RE2814
kinetic law: MODEL1310110027#
is described by: ECO:0000000
product: MODEL1310110027#
type: Reaction
reactant: MODEL1310110027#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110027#_29433906_1b79_4688_bdd0_4ff1485a8bad
is encoded by: hsa:2645
constant: false
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
name: GCK
is: P35557
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110027#_410ba3a7_c5f7_4398_b134_e14afe9e39a5
has only substance units: false
constant: false
name: SULT1A1
is encoded by: hsa:6817
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_f9a22df8_c00a_4741_9cd5_f23faa1848c0
type: Species
is encoded by: hsa:55650
is: Q9NUD9
has only substance units: false
name: PIGV
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110027#_1a68604c_f567_4d6e_ae8a_91896eaab8be
initial amount: NaN
initial concentration: NaN
name: PDE3A
is: SBO:0000252
has only substance units: false
constant: false
is: Q14432
type: Species
is encoded by: hsa:5139
boundary condition: true

metaM hdcea c
is: SBO:0000247
initial concentration: 1.0
name: Hexadecenoate (n-C16:1)
is: CHEBI:32372
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
initial amount: NaN
constant: false
is: HMDB03229
has only substance units: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110027#_635fc2c1_c127_468d_9496_df10ea92f566
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:5136
initial concentration: NaN
initial amount: NaN
constant: false
name: PDE1A
is: Q9Y633
has only substance units: false

metaR RE1709N
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
reactant: MODEL1310110027#
product: MODEL1310110027#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.96
modifier: MODEL1310110027#
type: Reaction
name: RE1709
kinetic law: MODEL1310110027#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110027#_84908a1b_89d8_477d_a7d4_16c58197a8aa
is: SBO:0000252
type: Species
is: O00750
name: PIK3C2B
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5287
boundary condition: true

metaM imp c
is: HMDB00175
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: C00130
name: IMP
type: Species
has only substance units: false
is: CHEBI:58053
constant: false
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130

http://identifiers.org/biomodels.db/MODEL1310110027#_f6c6580c_2f14_48d8_acd1_b6e30a17193d
constant: false
is: P19634
is encoded by: hsa:6548
type: Species
has only substance units: false
name: SLC9A1
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR CYTK4n
fast: false
product: MODEL1310110027#
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110027#
reactant: MODEL1310110027#
type: Reaction
is: SBO:0000176
name: cytidylate kinase (dCMP,GTP),nuclear
is described by: ECO:0000269
reversible: true

metaM ksi pre28 g
is: C00130
notes: FORMULA: C213H341N15O176S8X CHARGE: -9
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:58053
has only substance units: false
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 28
is: HMDB00175
initial amount: NaN

metaR KSII CORE2t
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
product: MODEL1310110027#
is described by: ECO:0000000
name: keratan sulfate II (core2) transport, golgi to extracellular
type: Reaction
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#

metaR AICARte
kinetic law: MODEL1310110027#
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110027#
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
reactant: MODEL1310110027#

metaR NDPK1
is: SBO:0000176
reactant: MODEL1310110027#
name: nucleoside-diphosphate kinase (ATP:GDP)
reversible: true
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110027#
fast: false
type: Reaction
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#

metaR r1629
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110027#
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#

metaM succ e
is: HMDB00254
initial amount: NaN
initial concentration: 1.0
is: CHEBI:30031
is: SBO:0000247
type: Species
name: succinate(2-)
boundary condition: false
constant: false
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
has only substance units: false

metaR r2133
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
reversible: true
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reactant: MODEL1310110027#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM dtdp m
initial concentration: 1.0
name: dTDP
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB01274
constant: false
type: Species
is: C00363
is: SBO:0000247
is: CHEBI:58369
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363

metaM utp e
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: SBO:0000247
name: UTP(4-)
is: CHEBI:46398
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
is: HMDB00285
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110027#_1baf1cf1_9d76_46ab_8346_3ee1b20fc082
is encoded by: hsa:6185
initial concentration: NaN
name: DAD1:DDOST:RPN1:RPN2
is encoded by: hsa:6184
has part: P04843
has part: Q53G02
has only substance units: false
initial amount: NaN
has part: P39656
boundary condition: true
has part: P04844
is encoded by: hsa:1603
is: SBO:0000297
type: Species
constant: false
is encoded by: hsa:1650

metaM lpchol hs e
initial concentration: 1.0
name: lysophosphatidylcholine
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0
is: CHEBI:60479
type: Species
is: SBO:0000247
boundary condition: false

metaM no e
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
is: HMDB03378
constant: false
initial amount: NaN
type: Species
name: Nitric oxide
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:16480
is: C00533
has only substance units: false

metaM ksii core4 pre1 g
has only substance units: false
notes: FORMULA: C36H60N3O25X CHARGE: 0
name: keratan sulfate II biosynthesis, precursor 1
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:28067
type: Species
initial concentration: 1.0
is: SBO:0000247

metaM cit e
type: Species
boundary condition: false
is: HMDB00094
initial concentration: 1.0
has only substance units: false
is: CHEBI:16947
name: citrate(3-)
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
constant: false

metaR r1291
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110027#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reactant: MODEL1310110027#
name: Postulated transport reaction
type: Reaction
product: MODEL1310110027#

metaM spc hs c
name: sphingosylphosphorylcholine
type: Species
is: http://identifiers.org/pubchem.compound/5311445
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false

metaR AHCYStd
name: diffusion of S-Adenosyl-L-homocysteine
fast: false
reversible: true
kinetic law: MODEL1310110027#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110027#
product: MODEL1310110027#

metaR GLNALANaEx
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
is described by: ECO:0000269
reactant: MODEL1310110027#
name: L-alanine/L-glutamine Na-dependent exchange (Gln-L in)
kinetic law: MODEL1310110027#
product: MODEL1310110027#
is: SBO:0000185
type: Reaction
reversible: false

metaM nrpphrsf e
constant: false
is: SBO:0000247
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
name: Sulfate derivative of norepinephrine
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/123747
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB02062

metaM HC01397 x
constant: false
initial concentration: 1.0
name: (S)-3-Hydroxyhexadecanoyl-CoA
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:27402

metaM pi n
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: CHEBI:43474
has only substance units: false
is: HMDB00973
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
name: hydrogenphosphate

http://identifiers.org/biomodels.db/MODEL1310110027#_46cc9e66_74df_4d0a_a458_c6538ee2e0c2
type: Species
has only substance units: false
is encoded by: hsa:AA788780
constant: false
name: _AA788780_1_c
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR NDPK2
name: nucleoside-diphosphate kinase (ATP:UDP)
reversible: true
product: MODEL1310110027#
modifier: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110027#

metaR r2132
reactant: MODEL1310110027#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110027#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
modifier: MODEL1310110027#
product: MODEL1310110027#
type: Reaction

metaM fpram c
constant: false
boundary condition: false
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
is: HMDB06211
has only substance units: false
type: Species
is: CHEBI:58478
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C8H15N3O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01329 EHMN_ABBREVIATION: C04640
initial concentration: 1.0
is: C04640

metaR FAOXC121C101m
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:1-->C10:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_f0bfc230_bde3_4dee_a460_7296f66ed258
constant: false
type: Species
boundary condition: true
name: DCK
is encoded by: hsa:1633
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: P27707

metaR GTHOm
product: MODEL1310110027#
is described by: ECO:0000254
reversible: false
name: glutathione oxidoreductase
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558,PMID:15149466 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
fast: false
modifier: MODEL1310110027#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.8.1.7
kinetic law: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_b14eb712_f623_4137_9bb8_03c9b5ce5420
type: Species
is: P54819
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: AK2
constant: false
is encoded by: hsa:204
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_f17b41b3_e86d_4903_9baa_9d8f86e275ff
boundary condition: true
type: Species
initial concentration: NaN
is: Q9UN76
is encoded by: hsa:11254
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
name: SLC6A14

metaR r0027
fast: false
is: SBO:0000176
modifier: MODEL1310110027#
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.14.13.39
reversible: true
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
type: Reaction
product: MODEL1310110027#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110027#_3d80719e_7497_4098_ba9e_59fcb5e60cb6
initial concentration: NaN
constant: false
is: Q9BY07
has only substance units: false
initial amount: NaN
is encoded by: hsa:57835
boundary condition: true
name: SLC4A5
is: SBO:0000252
type: Species

metaM prostgf2 c
is: CHEBI:57404
is: HMDB01139
type: Species
initial amount: NaN
name: prostaglandin F2alpha(1-)
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110027#_7afb594c_aaa1_443a_8884_be7d5acdd954
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
name: GALNT9
is: Q9HCQ5
is encoded by: hsa:50614
boundary condition: true
type: Species

metaM pmtcrn m
name: L-palmitoylcarnitine
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:17490
type: Species
is: HMDB00222
initial amount: NaN
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: SBO:0000247
initial concentration: 1.0

metaR DURIPP
is: SBO:0000176
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.4.2.3
fast: false
reversible: true
product: MODEL1310110027#
modifier: MODEL1310110027#
is described by: ECO:0000269
kinetic law: MODEL1310110027#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.1
name: deoxyuridine phosphorylase

http://identifiers.org/biomodels.db/MODEL1310110027#_438e48cd_2669_4326_a1a7_cb11e5d346a7
is encoded by: hsa:6569
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
is: Q7Z725
initial concentration: NaN
constant: false
boundary condition: true
name: SLC34A1

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

metaM m2mn l
notes: FORMULA: C26H45NO21 CHARGE: 0 INCHI: InChI=1/C26H45NO21/c1-6(32)27-11-15(36)20(10(5-31)42-23(11)41)46-25-18(39)22(14(35)8(3-29)44-25)48-26-19(40)21(13(34)9(4-30)45-26)47-24-17(38)16(37)12(33)7(2-28)43-24/h7-26,28-31,33-41H,2-5H2,1H3,(H,27,32)/t7-,8-,9-,10+,11+,12-,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23+,24-,25+,26+/m0/s1
is: HMDB06537
initial concentration: 1.0
constant: false
name: (alpha-D-mannosyl)2-beta-D-mannosyl-N-acetylglucosamine
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_ca7a13fd_3295_4d63_af46_6276a33719b0
is encoded by: hsa:1431
type: Species
boundary condition: true
name: CS
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN

metaR r0381
notes: GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.8.1.3 Confidence Level: 0 AUTHORS: PMID:13979247,PMID:16680556,PMID:7295801 NOTES:
name: hypotaurine:NAD+ oxidoreductase Taurine and hypotaurine metabolism EC:1.8.1.3
reversible: true
reactant: MODEL1310110027#
is described by: ECO:0000000
product: MODEL1310110027#
kinetic law: MODEL1310110027#
fast: false
type: Reaction
is: SBO:0000176

metaR GALASE18ly
is: SBO:0000176
is described by: ECO:0000000
fast: false
reactant: MODEL1310110027#
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110027#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110027#
reversible: false

metaM lpchol hs c
type: Species
has only substance units: false
name: lysophosphatidylcholine
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0
initial amount: NaN
is: CHEBI:60479
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaM dcyt n
type: Species
initial amount: NaN
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
is: CHEBI:15698
name: 2'-deoxycytidine
initial concentration: 1.0
constant: false
is: HMDB00014
is: SBO:0000247
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_3468379b_a778_4b51_b366_b6765e491fc1
initial amount: NaN
is: SBO:0000252
type: Species
is: Q9Y6T7
name: DGKB
boundary condition: true
is encoded by: hsa:1607
initial concentration: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_a7d1bc33_4929_40b9_aef7_498664cfe8c3
is: SBO:0000252
type: Species
name: TMEM54
is: Q969K7
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:113452
boundary condition: true
has only substance units: false

metaM urate c
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
is: HMDB00289
is: CHEBI:17775
initial amount: NaN
boundary condition: false
has only substance units: false
name: Urate
is: SBO:0000247
is: C00366

metaR PNTEH
type: Reaction
name: Hydrolase Class ( RXN R02973)
is version of: http://identifiers.org/ec-code/3.5.1.92
reactant: MODEL1310110027#
fast: false
is: SBO:0000176
product: MODEL1310110027#
reversible: false
modifier: MODEL1310110027#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) SUBSYSTEM: CoA catabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10567687,PMID:11491533 NOTES:EC 3.5.1- KEGG RXN R02973 RM
kinetic law: MODEL1310110027#

metaR NOt
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
name: NO transport (diffusion)
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)

http://identifiers.org/biomodels.db/MODEL1310110027#_5ee24d5b_e090_45c3_9f31_5638663f01f3
initial amount: NaN
name: PIP4K2C
constant: false
is: B3KQV3
is encoded by: hsa:79837
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR NDPK3
name: nucleoside-diphosphate kinase (ATP:CDP)
is: SBO:0000176
product: MODEL1310110027#
reactant: MODEL1310110027#
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110027#
type: Reaction
is described by: ECO:0000269
fast: false
reversible: true

metaM gm3 hs g
has only substance units: false
notes: FORMULA: C41H72N2O20FULLRCO CHARGE: -1 EHMN_ABBREVIATION: C04730
initial concentration: 1.0
boundary condition: false
name: alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide(1-)
constant: false
initial amount: NaN
is: CHEBI:60065
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_b7543bc9_cae2_45f1_ab79_a91e19f6dd0f
has only substance units: false
name: MGAT1
is encoded by: hsa:4245
is: P26572
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252

metaM pi m
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
name: hydrogenphosphate
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: HMDB00973
initial amount: NaN
is: SBO:0000247
is: C00009
constant: false
is: CHEBI:43474

metaR r2139
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110027#
is described by: ECO:0000000
fast: false
type: Reaction
modifier: MODEL1310110027#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
reversible: true
is: SBO:0000185

metaR r1559
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110027#
reactant: MODEL1310110027#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110027#
fast: false
reversible: true
type: Reaction

metaR OCD11COACPT1
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaR r1627
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110027#
is: SBO:0000185
reversible: true
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110027#
fast: false
is described by: ECO:0000000

metaM utp c
name: UTP
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
constant: false
is: HMDB00285
is: CHEBI:46398
is: SBO:0000247
is: C00075
initial amount: NaN

metaM 2octdectecoa m
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
initial concentration: 1.0
type: Species
is: HMDB02288
constant: false
initial amount: NaN
name: 2,6,9,12-octadecatetraenoylcoa

metaM ile L c
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
constant: false
is: HMDB00172
is: CHEBI:17191
name: L-isoleucine
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110027#_b9778e9c_584d_4219_aaa1_18ae0ade070f
name: ST3GAL1
type: Species
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:6482
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaR MCITS
reversible: false
fast: false
product: MODEL1310110027#
name: 2-methylcitrate synthase
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 2.3.3.5 Confidence Level: 2 AUTHORS: PMID:426765,PMID:4507604 NOTES:NCD new EC is 2.3.3.5 - NCD
is: SBO:0000176
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
is described by: ECO:0000000

metaR ABUTt2r
kinetic law: MODEL1310110027#
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000304
type: Reaction
modifier: MODEL1310110027#
name: 4-aminobutyrate reversible transport in via proton symport
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_402279a6_ca23_4d6f_9493_9d311504cdb6
name: TSTA3
initial concentration: NaN
is: Q13630
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:7264
has only substance units: false

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

metaM no c
name: Nitric oxide
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:16480
is: C00533
initial concentration: 1.0
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
is: HMDB03378
constant: false
boundary condition: false

metaM akg e
is: HMDB00208
name: 2-oxoglutarate(2-)
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:16810
type: Species
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
constant: false

metaR r0842
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.3.1.72
reversible: true
type: Reaction
name: Postulated transport reaction
is described by: ECO:0000000
modifier: MODEL1310110027#
is: SBO:0000185
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
kinetic law: MODEL1310110027#
fast: false

metaM 7dhf e
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
type: Species
name: heptaglutamyl folate (DHF)
is: HMDB06559
initial amount: NaN
initial concentration: 1.0

metaR HISD
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/4.3.1.3
is described by: ECO:0000269
kinetic law: MODEL1310110027#
reversible: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110027#
name: histidase
fast: false
notes: GENE_ASSOCIATION: (3034.1) SUBSYSTEM: Histidine metabolism EC Number: 4.3.1.3 Confidence Level: 4 AUTHORS: PMID:8530107 NOTES:
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_b2505a7d_8e81_48b9_adae_cde717dc2cb7
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:197257
name: LDHD
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR H2O2syn
reversible: false
is: SBO:0000176
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (53905.1) or (50506.1) or (53905.2) SUBSYSTEM: Tyrosine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15677770,PMID:15972824 NOTES:SAB lumped reaction--first O2 goes to superoxide radical, then dismutes to H2O2
fast: false
product: MODEL1310110027#
name: Hydrogen peroxide synthesis (NADPH dependent)
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.6.3.1
is described by: ECO:0000304
kinetic law: MODEL1310110027#
type: Reaction

metaM cdp n
initial amount: NaN
constant: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
name: CDP(3-)
initial concentration: 1.0
is: HMDB01546
is: CHEBI:58069

metaM Lcystin c
initial amount: NaN
name: L-cystine
has only substance units: false
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
is: CHEBI:16283
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB00192
constant: false

metaR NDPK4
fast: false
kinetic law: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: nucleoside-diphosphate kinase (ATP:dTDP)
modifier: MODEL1310110027#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
product: MODEL1310110027#
is described by: ECO:0000269
reactant: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_e03068ce_616f_4c27_ac65_ea552e2c426a
is: B3KT86
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:109
name: ADCY3
boundary condition: true
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_5dd170c6_114c_40f6_a294_da94e6c68c28
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:159963
name: SLC5A12
type: Species
is: Q1EHB4
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaM ala B e
name: beta-alanine
boundary condition: false
initial concentration: 1.0
is: CHEBI:16958
is: HMDB00056
initial amount: NaN
has only substance units: false
type: Species
constant: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
is: SBO:0000247

metaR VALTA
name: valine transaminase
is: SBO:0000176
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
product: MODEL1310110027#
type: Reaction
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.6.1.42
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
fast: false
is described by: ECO:0000269
reversible: true

metaR NDPK9n
reversible: true
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110027#
modifier: MODEL1310110027#
product: MODEL1310110027#
kinetic law: MODEL1310110027#

metaR UMPK4n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110027#
reversible: true
product: MODEL1310110027#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110027#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110027#
name: UMP kinase (GTP),nuclear
is: SBO:0000176

metaR FAOXC8DCC6DCx
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8DC-->C6DC)x
type: Reaction

metaR ATP2ter
reactant: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
kinetic law: MODEL1310110027#
is described by: ECO:0000000
name: AMP/ATP transporter, endoplasmic reticulum
reversible: true
product: MODEL1310110027#
is: SBO:0000185

metaR r1628
product: MODEL1310110027#
fast: false
reversible: true
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110027#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

metaR G14T2g
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
product: MODEL1310110027#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
modifier: MODEL1310110027#
is: SBO:0000176

metaR EX udpgal LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP-D-galactose(2-) exchange
type: Reaction

metaR EX lac D LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-lactate exchange
type: Reaction

metaM cholcoa x
boundary condition: false
has only substance units: false
is: HMDB01374
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:57373
name: choloyl-CoA(4-)
is: SBO:0000247
initial amount: NaN

metaR D3AIBTm
product: MODEL1310110027#
kinetic law: MODEL1310110027#
is described by: ECO:0000000
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
reactant: MODEL1310110027#
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
is: SBO:0000176

metaR NDPK1n
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:15242782 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
name: nucleoside-diphosphate kinase (ATP:GDP), nuclear
modifier: MODEL1310110027#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110027#
type: Reaction
is described by: ECO:0000134
is: SBO:0000176
reactant: MODEL1310110027#

metaM amp c
is: HMDB00045
notes: FORMULA: C10H12N5O7P CHARGE: -2
is: CHEBI:3322
has only substance units: false
boundary condition: false
name: AMP
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: C00020

metaM CE2422 m
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:28387
has only substance units: false
is: HMDB11123
type: Species
initial amount: NaN
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA

metaR r1557
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110027#
fast: false
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110027#
reactant: MODEL1310110027#

metaR EX xoltri27 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 7-alpha,27-Dihydroxycholesterol exchange
type: Reaction

metaM man1p c
name: D-Mannose 1-phosphate
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:35374
initial amount: NaN
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
constant: false
is: HMDB06330
initial concentration: 1.0

metaR 10FTHFtm
is described by: ECO:0000000
fast: false
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
reversible: true
product: MODEL1310110027#
type: Reaction

metaR LTC4CP
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
kinetic law: MODEL1310110027#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110027#
name: Leukotriene C4 carboxypeptidase
type: Reaction
reactant: MODEL1310110027#
fast: false

metaM prostgf2 e
initial concentration: 1.0
is: CHEBI:57404
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
boundary condition: false
name: prostaglandin F2alpha(1-)
type: Species
is: HMDB01139

http://identifiers.org/biomodels.db/MODEL1310110027#_61a3f496_f0de_462f_982a_b3c948b574fc
name: _D29675_1_e
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:D29675
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR NDPK5
is: SBO:0000176
reactant: MODEL1310110027#
product: MODEL1310110027#
name: Nucleoside-diphosphate kinase (ATP:dGDP)
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
modifier: MODEL1310110027#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110027#
fast: false
reversible: true

metaM retinal cis 13 c
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB06220
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:45487
boundary condition: false
name: 13-cis-retinal

metaM urate e
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: C00366
constant: false
is: HMDB00289
has only substance units: false
type: Species
is: CHEBI:17775
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
name: Urate
boundary condition: false

metaR r1625
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110027#
modifier: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
fast: false

metaR r0504
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
reversible: true
modifier: MODEL1310110027#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.3.3.10
is described by: ECO:0000000
reactant: MODEL1310110027#
product: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:

metaM chol n
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: CHEBI:15354
has only substance units: false
is: HMDB00097
boundary condition: false
type: Species
name: choline
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247

metaM mpdol L c
notes: FORMULA: C1300H2128N20O220P20 CHARGE: -20 INCHI: InChI=1S/C47H82N2O22P2/c1-26(2)13-9-14-27(3)15-10-16-28(4)17-11-18-29(5)19-12-20-30(6)21-22-64-72(60,61)71-73(62,63)70-46-37(49-32(8)54)40(57)43(35(25-52)67-46)68-45-36(48-31(7)53)39(56)44(34(24-51)66-45)69-47-42(59)41(58)38(55)33(23-50)65-47/h13,15,17,19,30,33-47,50-52,55-59H,9-12,14,16,18,20-25H2,1-8H3,(H,48,53)(H,49,54)(H,60,61)(H,62,63)/b27-15+,28-17+,29-19+/t30?,33-,34-,35-,36-,37-,38-,39-,40-,41+,42+,43-,44-,45+,46-,47+/m1/s1
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
is: SBO:0000247
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human liver homolog
is: CHEBI:18396
has only substance units: false
initial amount: NaN

metaR r2137
reversible: true
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110027#
product: MODEL1310110027#
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
type: Reaction
modifier: MODEL1310110027#
reactant: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:

metaR SARCStex
name: Sarcosine transport (extracellular to cytosol)
product: MODEL1310110027#
reversible: false
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110027#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:5096515 NOTES:MM

metaR NDPK1m
reversible: true
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
kinetic law: MODEL1310110027#
is described by: ECO:0000254
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
fast: false
product: MODEL1310110027#
is: SBO:0000176
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.

metaM ala B c
type: Species
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
initial amount: NaN
constant: false
is: CHEBI:16958
is: SBO:0000247
is: HMDB00056
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: beta-alanine

metaR ACGAMPM
name: phosphoacetylglucosamine mutase
reactant: MODEL1310110027#
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
reversible: true
fast: false
is: SBO:0000176
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/5.4.2.3
type: Reaction
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD
is described by: ECO:0000269

metaR RE2814R
reversible: true
product: MODEL1310110027#
is described by: ECO:0000000
name: RE2814
fast: false
reactant: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
is: SBO:0000176

metaR r1985
is described by: ECO:0000000
kinetic law: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110027#
fast: false
modifier: MODEL1310110027#
name: Y+LAT2 Utilized transport
reversible: false
product: MODEL1310110027#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110027#_4b49be20_eb47_4340_b400_e928f53df94c
constant: false
boundary condition: true
is encoded by: hsa:8611
is: G3XA95
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: PPAP2A
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_c0b094d8_6745_4838_9fec_cca773ab0045
is: SBO:0000252
type: Species
is: P30613
has only substance units: false
is encoded by: hsa:5313
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
name: PKLR

metaR r1556
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
product: MODEL1310110027#
fast: false
is: SBO:0000185
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#

metaM 7dhf c
boundary condition: false
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
is: SBO:0000247
name: heptaglutamyl folate (DHF)
constant: false
type: Species
initial concentration: 1.0
is: HMDB06559
initial amount: NaN
has only substance units: false

metaM akg c
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB00208
name: 2-Oxoglutarate
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
type: Species
is: C00026
constant: false
is: CHEBI:16810
initial amount: NaN
has only substance units: false

metaM pa hs n
type: Species
is: CHEBI:57739
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
name: phosphatidate(2-)

http://identifiers.org/biomodels.db/MODEL1310110027#_4b2f06bb_b8dd_4e20_acf1_a427bfed8cc5
initial amount: NaN
name: IDH1
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:3417
type: Species
has only substance units: false
is: O75874

metaR FAOXC6DCC4DCx
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6DC-->C4DC)x
type: Reaction

metaR NDPK6
fast: false
type: Reaction
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
is: SBO:0000176
modifier: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.6
name: Nucleoside-diphosphate kinase (ATP:dUDP)
product: MODEL1310110027#

metaM Lcystin e
is: CHEBI:16283
name: L-cystine
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
is: SBO:0000247
type: Species
boundary condition: false
constant: false
is: HMDB00192
initial amount: NaN

metaM frdp c
initial concentration: 1.0
is: C00448
is: SBO:0000247
is: HMDB00961
initial amount: NaN
boundary condition: false
is: CHEBI:175763
constant: false
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
type: Species
name: Farnesyl diphosphate
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_b7c58176_d903_4044_8f39_ca04582ff97c
is: SBO:0000252
is: Q6FG42
has only substance units: false
type: Species
name: NDUFA7
boundary condition: true
is encoded by: hsa:4701
constant: false
initial concentration: NaN
initial amount: NaN

metaR HCO3 CLt
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110027#
reversible: true
modifier: MODEL1310110027#
is described by: ECO:0000269
name: bicarbonate transport (Cl-/HCO3- exchange)
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (6522.1) or (83697.1) or (6521.1) or (6508.2) or (6508.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11302728,PMID:12027221,PMID:14722772 NOTES:MM
fast: false
reactant: MODEL1310110027#

metaR ITPtn
type: Reaction
is described by: ECO:0000000
name: ITP nuclear transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110027#
is: SBO:0000185
product: MODEL1310110027#
reactant: MODEL1310110027#
reversible: true

metaR r0618
kinetic law: MODEL1310110027#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
product: MODEL1310110027#
type: Reaction
fast: false
reactant: MODEL1310110027#
reversible: true
is: SBO:0000176
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2

metaR r1626
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110027#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110027#
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110027#

metaR OBDHc
product: MODEL1310110027#
name: 2-Oxobutanoate dehydrogenase, cytosolic
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.7.2 Confidence Level: 2 AUTHORS: NOTES:as shown in Lehninger (4th ed.) for threonine degradation MM
kinetic law: MODEL1310110027#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110027#
is described by: ECO:0000000
reversible: false

metaM amet m
constant: false
type: Species
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: C00019
name: S-Adenosyl-L-methionine
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB01185
is: CHEBI:15414
is: SBO:0000247

metaR O2Stm
fast: false
is: SBO:0000185
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction
reactant: MODEL1310110027#
product: MODEL1310110027#
name: superoxide anion transport via diffusion (mitochondria)

http://identifiers.org/biomodels.db/MODEL1310110027#_9385c1d1_8897_4f0a_ab5e_5d96a805d74c
is encoded by: hsa:1806
is: Q12882
constant: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: DPYD
has only substance units: false
is: SBO:0000252

metaR ADPCOACROT
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of adipoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_6c7fd21d_d4ab_47b0_ac7d_f5482454345c
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:9791
initial concentration: NaN
is: P48651
name: PTDSS1
has only substance units: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110027#_1057213d_02eb_401b_8476_616e6b53b734
initial amount: NaN
constant: false
initial concentration: NaN
is: P19404
is encoded by: hsa:4729
boundary condition: true
is: SBO:0000252
type: Species
name: NDUFV2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_d207bba7_eb5b_40ee_a12b_a6bab2c6f930
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

metaM duri n
is: CHEBI:16450
name: 2'-deoxyuridine
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: SBO:0000247
is: HMDB00012
constant: false
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR EX n2m2nmasn LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R exchange
type: Reaction

metaM rib D e
initial concentration: 1.0
type: Species
is: CHEBI:16988
name: D-ribose
is: HMDB00283
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_9bdafca8_e754_46c8_bac1_d970e1d6b9f8
name: GCNT3
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:9245
initial amount: NaN
is: O95395
is: SBO:0000252
initial concentration: NaN
type: Species

metaM lys L x
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
name: L-lysinium(1+)
is: HMDB00182
is: CHEBI:32551
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_6479c0a7_5efc_4d2b_b795_398f06ca8085
is: Q92521
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:9488
initial amount: NaN
constant: false
is: SBO:0000252
name: PIGB

http://identifiers.org/biomodels.db/MODEL1310110027#_03869b6d_2d47_48ea_80a0_629b1d2f3fc2
constant: false
boundary condition: true
name: COX5A
type: Species
initial concentration: NaN
is encoded by: hsa:9377
has only substance units: false
is: P20674
initial amount: NaN
is: SBO:0000252

metaM dgtp n
initial amount: NaN
is: HMDB01440
constant: false
boundary condition: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
initial concentration: 1.0
is: C00286
has only substance units: false
name: dGTP
type: Species
is: SBO:0000247
is: CHEBI:16497

metaR FUCASEly
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110027#
name: alpha-fucosidase, lysosomal
notes: GENE_ASSOCIATION: (2517.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.51 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110027#
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.2.1.51
is: SBO:0000176
fast: false
reversible: false
modifier: MODEL1310110027#

metaM gchola c
initial amount: NaN
is: HMDB00138
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:58235
name: glycocholate
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
has only substance units: false

metaR RE1709C
fast: false
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
name: RE1709
type: Reaction
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_775680ad_cb9f_4960_add6_307c6fe9969e
is: SBO:0000252
name: INPPL1
boundary condition: true
is: O15357
is encoded by: hsa:3636
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
type: Species

metaM dtdp c
constant: false
is: C00363
initial concentration: 1.0
boundary condition: false
is: HMDB01274
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
has only substance units: false
is: CHEBI:58369
is: SBO:0000247
initial amount: NaN
name: dTDP
type: Species

metaM cdpdag hs c
is: SBO:0000247
is: CHEBI:58332
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
type: Species
has only substance units: false
boundary condition: false
name: CDP-diacylglycerol(2-)

metaM dudp c
constant: false
type: Species
initial amount: NaN
is: CHEBI:60471
is: C01346
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: HMDB01000
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: dUDP
has only substance units: false

metaR r0732
reversible: false
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reactant: MODEL1310110027#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110027#
product: MODEL1310110027#
fast: false

metaR r1298
kinetic law: MODEL1310110027#
is described by: ECO:0000000
name: Vesicular transport
product: MODEL1310110027#
fast: false
reactant: MODEL1310110027#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_5685518b_9198_41b9_9486_ab3b24b89d86
type: Species
has only substance units: false
is: E9KL42
is encoded by: hsa:641371
boundary condition: true
initial concentration: NaN
name: ACOT1
initial amount: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_86ea0ad5_026e_4ee5_89d3_67d7daccccbe
initial concentration: NaN
name: PDE1B
initial amount: NaN
is encoded by: hsa:5153
is: Q7Z364
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
type: Species

metaM 3mob e
boundary condition: false
is: CHEBI:11851
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
name: 3-methyl-2-oxobutanoate
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
is: HMDB00019
has only substance units: false
is: SBO:0000247

metaR FK
name: Fucokinase
fast: false
notes: GENE_ASSOCIATION: (197258.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.52 Confidence Level: 0 AUTHORS: NOTES:kh 1/6/03 NCD
product: MODEL1310110027#
modifier: MODEL1310110027#
type: Reaction
reactant: MODEL1310110027#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.52
is described by: ECO:0000000
kinetic law: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_a8060e72_9aeb_4778_96bc_41b9decbec2f
name: ADCY9
is: O60503
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:115
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_c3bb53dd_b68b_4230_b2bc_fe4f8e819db8
is: SBO:0000252
initial concentration: NaN
name: _H77542_1_c
type: Species
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:H77542

metaR r0616
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
is: SBO:0000176
product: MODEL1310110027#

metaM gmp c
is: C00144
initial amount: NaN
name: GMP
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
has only substance units: false
boundary condition: false
is: CHEBI:58115
is: HMDB01397
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247

metaM lpam m
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
is: HMDB00962
type: Species
name: lipoamide
constant: false
initial amount: NaN
is: CHEBI:17460
boundary condition: false
has only substance units: false

metaM 3mob c
name: 3-methyl-2-oxobutanoate
is: SBO:0000247
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:11851
boundary condition: false
is: HMDB00019
constant: false
has only substance units: false

metaM pi x
initial amount: NaN
is: HMDB00973
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:43474
name: hydrogenphosphate
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009

http://identifiers.org/biomodels.db/MODEL1310110027#_0fe2cca6_81ae_44d0_9b5c_b55ac3796537
initial amount: NaN
is encoded by: hsa:5320
name: PLA2G2A
boundary condition: true
is: SBO:0000252
constant: false
is: P14555
initial concentration: NaN
has only substance units: false
type: Species

metaR FADtru
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
type: Reaction
is described by: ECO:0000000
fast: false
reversible: false
product: MODEL1310110027#
name: FAD transporter, endoplasmic reticulum
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110027#_51ea7194_06f9_47c1_a746_85acde23faa6
initial concentration: NaN
type: Species
boundary condition: true
is: E7EQF2
has only substance units: false
is encoded by: hsa:54677
is: SBO:0000252
constant: false
name: CROT
initial amount: NaN

metaR PE HSter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:
name: phosphatidylethanolamine scramblase
type: Reaction
kinetic law: MODEL1310110027#
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: true
product: MODEL1310110027#
reactant: MODEL1310110027#

metaR r0733
type: Reaction
fast: false
reactant: MODEL1310110027#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.12
reversible: false
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_eafc4854_1c8f_4357_96f1_c438f3e36796
is: Q8TDB8
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:144195
name: SLC2A14
constant: false
type: Species

metaM glu L e
is: HMDB00148
name: L-glutamate(1-)
initial concentration: 1.0
is: CHEBI:29985
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false

metaM pmtcrn r
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: HMDB00222
type: Species
constant: false
name: L-palmitoylcarnitine
has only substance units: false
boundary condition: false
is: CHEBI:17490

metaR DASCBR
notes: GENE_ASSOCIATION: (2745.1) or (51022.2) or (51022.1) SUBSYSTEM: Vitamin C metabolism EC Number: 1.6.5.4 Confidence Level: 4 AUTHORS: PMID:11297543 NOTES:
reversible: false
product: MODEL1310110027#
is: SBO:0000176
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.8.4.1
reactant: MODEL1310110027#
fast: false
modifier: MODEL1310110027#
name: dehydroascorbate reductase
is described by: ECO:0000269
type: Reaction

metaR r1554
type: Reaction
product: MODEL1310110027#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110027#
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110027#

metaR DNDPt35m
product: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dGDP transport via dADP antiport
reversible: false
is: SBO:0000185
modifier: MODEL1310110027#
is described by: ECO:0000269
reactant: MODEL1310110027#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110027#_a4faf354_b5a6_4a38_9bb1_4003d1885aae
is: A8MU28
type: Species
boundary condition: true
name: NAE1
initial concentration: NaN
constant: false
is encoded by: hsa:8883
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaM succ m
type: Species
is: HMDB00254
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
has only substance units: false
constant: false
is: SBO:0000247
name: Succinate
is: C00042
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:30031

metaM rib D c
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:16988
name: D-ribose
is: HMDB00283
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaM gchola e
is: HMDB00138
has only substance units: false
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
name: glycocholate
notes: FORMULA: C26H43NO6 CHARGE: 0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_52cfc4f9_3549_4d16_9e40_47cdc9bc257c
initial concentration: NaN
name: IDH3A:IDH3B:IDH3G
type: Species
is: SBO:0000297
constant: false
is encoded by: hsa:3420
boundary condition: true
initial amount: NaN
has only substance units: false

metaM 4mop m
name: 4-methyl-2-oxopentanoate
boundary condition: false
constant: false
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB00695
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
is: CHEBI:17865
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_55f29825_f512_4bd9_b34f_1dd1dcd327d5
has only substance units: false
is: P11498
boundary condition: true
is encoded by: hsa:5091
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
name: PC
constant: false

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

metaM ksii core2 pre6 g
is: CHEBI:28067
type: Species
boundary condition: false
constant: false
name: keratan sulfate II biosynthesis, precursor 6
initial concentration: 1.0
notes: FORMULA: C61H98N5O46SX CHARGE: -2
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR GLNS
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110027#
is described by: ECO:0000254
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.15
type: Reaction
is: SBO:0000176
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
name: glutamine synthetase

metaR r0730
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
fast: false
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110027#
type: Reaction
reactant: MODEL1310110027#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
product: MODEL1310110027#

metaM HC01409 m
is: CHEBI:27540
has only substance units: false
notes: FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h14-16,20-22,26,37-38H,4-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05270
name: Hexanoyl-CoA
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false

metaM dtdp e
initial concentration: 1.0
is: HMDB01274
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:58369
has only substance units: false
type: Species
constant: false
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363

metaR r0242
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:
is: SBO:0000176
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
fast: false
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/6.2.1.1
type: Reaction
product: MODEL1310110027#
reversible: true
is described by: ECO:0000000

metaR r1553
reactant: MODEL1310110027#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction
product: MODEL1310110027#
is described by: ECO:0000000
kinetic law: MODEL1310110027#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaM CE5117 m
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:57923
initial concentration: 1.0
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117

metaR r0178
kinetic law: MODEL1310110027#
reversible: true
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.5.1.21
fast: false
product: MODEL1310110027#
reactant: MODEL1310110027#
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110027#_5f606232_0baf_4d19_8ffe_68bd2c6e4260
boundary condition: true
initial amount: NaN
name: PLCB1
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:23236
constant: false

metaM 2oxoadp c
has only substance units: false
is: CHEBI:57499
is: HMDB00225
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
name: 2-oxoadipate(2-)
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_d5a8306d_63ee_4639_b018_8dad12df3e79
name: SDHC
type: Species
is: Q99643
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6391
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false

metaR r0509
notes: GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: 1.3.5.1 Confidence Level: 0 AUTHORS: PMID:2843227 NOTES:
reversible: false
fast: false
kinetic law: MODEL1310110027#
is: SBO:0000176
name: Succinate:ubiquinone oxidoreductase Citrate cycle (TCA cycle) EC:1.3.5.1
is described by: ECO:0000000
product: MODEL1310110027#
reactant: MODEL1310110027#
type: Reaction

metaR r0614
is: SBO:0000176
fast: false
is described by: ECO:0000000
reversible: true
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
kinetic law: MODEL1310110027#
type: Reaction
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_f6312082_9713_4eac_8fac_6a881200bfe5
constant: false
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: NDUFA12
has only substance units: false
initial concentration: NaN
is encoded by: hsa:55967
is: F8VQS7

metaM bglc e
type: Species
is: SBO:0000247
is: C08277
is: HMDB00792
name: beta-glucans
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C1200000H2200000O1100000 CHARGE: 0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110027#_509884cf_e785_45d9_ad70_c91ec490ec4e
initial amount: NaN
is encoded by: hsa:23236
constant: false
boundary condition: true
is: SBO:0000252
type: Species
name: PLCB1
initial concentration: NaN
is: Q9NQ66
has only substance units: false

metaM lnlccoa r
is: HMDB01064
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
name: linoleic coenzyme A
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
is: http://identifiers.org/pubchem.compound/5462164
boundary condition: false

metaR r0731
reversible: false
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
kinetic law: MODEL1310110027#
fast: false
type: Reaction
reactant: MODEL1310110027#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
product: MODEL1310110027#

metaM tymsf c
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
type: Species
is: HMDB06409
is: SBO:0000247
constant: false
name: Tyramine O-sulfate
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110027#_b1eefae6_5182_4fd5_9aed_bb3f0fa31575
constant: false
boundary condition: true
is encoded by: hsa:223
initial concentration: NaN
name: ALDH9A1
has only substance units: false
is: P49189
initial amount: NaN
type: Species
is: SBO:0000252

metaM utp n
has only substance units: false
is: HMDB00285
is: SBO:0000247
is: CHEBI:46398
name: UTP(4-)
constant: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species

metaM glu L c
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
name: L-glutamate(1-)
is: SBO:0000247
constant: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
is: CHEBI:29985
is: HMDB00148
initial amount: NaN

metaR 2AMADPTm
modifier: MODEL1310110027#
product: MODEL1310110027#
reversible: true
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
is: SBO:0000185
kinetic law: MODEL1310110027#
type: Reaction
reactant: MODEL1310110027#
fast: false
name: L-2-aminoadipate shuttle (cytosol/mitochondria)
is described by: ECO:0000269

metaR THYOXt2
type: Reaction
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
is described by: ECO:0000269
kinetic law: MODEL1310110027#
reversible: true
product: MODEL1310110027#
name: T4 transport via facilitated diffusion
reactant: MODEL1310110027#
is: SBO:0000185
fast: false

metaM HC01602 c
is: SBO:0000247
initial concentration: 1.0
is: C00234
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:57454
initial amount: NaN
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
name: 10-Formyltetrahydrofolate
type: Species

metaM ile L e
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
has only substance units: false
is: HMDB00172
name: L-isoleucine
boundary condition: false
type: Species
is: CHEBI:17191
is: SBO:0000247

metaR r1552
product: MODEL1310110027#
type: Reaction
fast: false
kinetic law: MODEL1310110027#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110027#

metaR DCYTt
type: Reaction
kinetic law: MODEL1310110027#
fast: false
is described by: ECO:0000000
name: deoxycytidine transport via diffusion
is: SBO:0000185
reactant: MODEL1310110027#
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
reversible: true

metaM nadh x
boundary condition: false
constant: false
name: Nicotinamide adenine dinucleotide - reduced
initial concentration: 1.0
is: CHEBI:57945
has only substance units: false
is: HMDB01487
initial amount: NaN
is: C00004
is: http://identifiers.org/pubchem.compound/3306
is: SBO:0000247
type: Species

metaR r0179
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.1.1.27
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16
product: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110027#
reversible: true
type: Reaction
is: SBO:0000176

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

metaR r0400
is version of: http://identifiers.org/ec-code/1.2.4.4
kinetic law: MODEL1310110027#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
reactant: MODEL1310110027#
modifier: MODEL1310110027#
reversible: true
is: SBO:0000176
fast: false

metaR FAOXC184C163m
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C18:4-->C16:3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_5012903f_5282_4744_b7fc_6d2edc125742
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:286016
name: TPI1P2
initial concentration: NaN
boundary condition: true

metaR C14STRr
name: C-14 sterol reductase
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.70
reversible: false
product: MODEL1310110027#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110027#
is described by: ECO:0000134
reactant: MODEL1310110027#

metaR r1299
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110027#
reactant: MODEL1310110027#
type: Reaction
name: Vesicular transport
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110027#

metaM cit m
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: C00158
initial amount: NaN
boundary condition: false
name: Citrate
type: Species
constant: false
is: CHEBI:16947
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB00094

http://identifiers.org/biomodels.db/MODEL1310110027#_69d8f19f_6891_486b_b2c2_b2e697d8ca46
constant: false
is: E9PB82
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:3295
is: SBO:0000252
name: HSD17B4

metaM HC00591 c
type: Species
initial concentration: 1.0
name: 2-oxoglutaramate
boundary condition: false
is: CHEBI:16769
constant: false
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
initial amount: NaN
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_3caff56c_1346_4fa7_a835_5ad8e640bd5a
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:2222
name: FDFT1
is: P37268
is: SBO:0000252

metaM m4mpdol L c
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:37633
constant: false
boundary condition: false
notes: FORMULA: C1540H2528N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
initial concentration: 1.0
type: Species
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog

metaM ibcoa m
is: CHEBI:57338
type: Species
initial amount: NaN
is: HMDB01243
boundary condition: false
is: SBO:0000247
name: isobutyryl-CoA(4-)
constant: false
initial concentration: 1.0
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,34-35H,5-10H2,1-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00462 EHMN_ABBREVIATION: C00630
has only substance units: false

metaR r2131
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reversible: true
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
type: Reaction
modifier: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#

metaM 7dhf m
is: SBO:0000247
is: HMDB06559
initial concentration: 1.0
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
has only substance units: false
name: heptaglutamyl folate (DHF)
boundary condition: false
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_935ccbab_fa6e_4024_bf12_be0590fc924e
initial concentration: NaN
is: Q9NY65
type: Species
is encoded by: hsa:1962
initial amount: NaN
boundary condition: true
name: EHHADH
is: SBO:0000252
has only substance units: false
constant: false

metaM vitd3 e
constant: false
initial amount: NaN
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
type: Species
has only substance units: false
boundary condition: false
is: HMDB00876
initial concentration: 1.0
name: calciol
is: SBO:0000247
is: CHEBI:28940

http://identifiers.org/biomodels.db/MODEL1310110027#_3cfedd38_0e63_4fe2_8007_817c996c6316
name: _NOS2A_1_e
initial concentration: NaN
is encoded by: hsa:NOS2A
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
constant: false
has only substance units: false

metaM c226coa c
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205479
boundary condition: false
is: SBO:0000247
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
is: C16169
constant: false
name: cervonyl coenzyme A
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_d3d7dd36_3b4b_4ada_adb2_7c21e879d534
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:23057
name: NMNAT2
initial concentration: NaN
type: Species

metaM gmp g
constant: false
type: Species
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
name: GMP(3-)
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB01397
boundary condition: false
is: CHEBI:58115

metaR TAGt
is described by: ECO:0000000
product: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110027#
is: SBO:0000185
name: triacylglycerol transport
reversible: true
reactant: MODEL1310110027#

metaR r1551
product: MODEL1310110027#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110027#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110027#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM HC02210 c
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:34939
name: prostaglandin-d3
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_52c7288a_32f7_48c3_9ad6_da2bb8ab7995
type: Species
name: COX6B2
is: Q6YFQ2
is encoded by: hsa:125965
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false

metaR r0494
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
type: Reaction
is: SBO:0000176
reversible: true
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
product: MODEL1310110027#
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
fast: false

metaM pheacgln c
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
type: Species
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58310
constant: false
is: HMDB06344
has only substance units: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110027#_1374e347_cb91_4227_b3d5_79df6b6ffbec
boundary condition: true
constant: false
is: SBO:0000252
type: Species
name: ALDH1B1
initial concentration: NaN
is: P30837
has only substance units: false
initial amount: NaN
is encoded by: hsa:219

metaM gacpail hs c
boundary condition: false
is: CHEBI:61548
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB01401
is: C00092
has only substance units: false
name: glucosaminyl-acylphosphatidylinositol
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
constant: false

metaR r2130
product: MODEL1310110027#
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
modifier: MODEL1310110027#
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110027#_48c7f50b_4808_4f68_80c8_707c0e465471
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:4512
initial amount: NaN
initial concentration: NaN
type: Species
is: Q7GXY8
name: COX1
has only substance units: false

metaM CE5121 m
name: trans-3-decenoyl-CoA
type: Species
constant: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
is: SBO:0000247
is: CHEBI:57449
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110027#_90c2ebdd_9afc_483a_b8a0_3478f8a64903
initial concentration: NaN
constant: false
initial amount: NaN
name: _AV717590_1_c
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:AV717590

http://identifiers.org/biomodels.db/MODEL1310110027#_139d1479_3c95_4b1d_a9d6_f56c8a317ad7
initial concentration: NaN
has only substance units: false
boundary condition: true
is: P22413
constant: false
type: Species
name: ENPP1
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5167

http://identifiers.org/biomodels.db/MODEL1310110027#_15c0ecaa_ddf6_4043_9c9f_72fcf0886b29
initial concentration: NaN
is: P46721
has only substance units: false
name: SLCO1A2
is: SBO:0000252
boundary condition: true
constant: false
type: Species
is encoded by: hsa:6579
initial amount: NaN

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

metaR DCK1n
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
name: Deoxycytidine kinase, nuclear (ATP)
is version of: http://identifiers.org/ec-code/2.7.1.74
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
reversible: true
is: SBO:0000176
type: Reaction
modifier: MODEL1310110027#
is described by: ECO:0000269
fast: false

metaM dhdascb c
boundary condition: false
is: HMDB01264
name: dehydroascorbide(1-)
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
constant: false
initial concentration: 1.0
is: CHEBI:58070

metaR GLYC St
kinetic law: MODEL1310110027#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:9604805 NOTES:
reactant: MODEL1310110027#
product: MODEL1310110027#
is described by: ECO:0000000
reversible: false
name: L-glycerate export
fast: false
type: Reaction

metaR DHAAt1r
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6515.1) or (6513.1) or (6517.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:15705056,PMID:2656669,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
type: Reaction
fast: false
modifier: MODEL1310110027#
reactant: MODEL1310110027#
reversible: true
product: MODEL1310110027#
is: SBO:0000185
name: dehydroascorbate transport (uniport)
kinetic law: MODEL1310110027#

metaR FATP2t
reactant: MODEL1310110027#
is: SBO:0000185
product: MODEL1310110027#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
reversible: true
name: fatty acid electroneutral transport
fast: false
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_819df88f_62b8_46cf_a62f_c7320d7e8fb8
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
name: PGK1
is: P00558
constant: false
is encoded by: hsa:5230

metaR DNDPt15m
is: SBO:0000185
name: dUDP transport via dGDP antiport
is described by: ECO:0000269
kinetic law: MODEL1310110027#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
reactant: MODEL1310110027#
product: MODEL1310110027#
modifier: MODEL1310110027#

metaM tymsf e
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
initial amount: NaN
name: Tyramine O-sulfate
type: Species
has only substance units: false
is: HMDB06409

http://identifiers.org/biomodels.db/MODEL1310110027#_2a161271_e732_4714_b9ef_e7cf807e7cf9
constant: false
is: H7C5B8
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: NDUFB2
boundary condition: true
is encoded by: hsa:4708

metaR BAAT2x
modifier: MODEL1310110027#
is described by: ECO:0000269
name: bile acid Coenzyme A: amino acid N-acyltransferase
type: Reaction
fast: false
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.3.1.65
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
reactant: MODEL1310110027#
is: SBO:0000176
reversible: false

metaR EX spc hs LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: sphingosylphosphorylcholine (homo sapiens) exchange
type: Reaction

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

metaM gam e
initial amount: NaN
type: Species
constant: false
is: CHEBI:17315
is: HMDB01514
name: D-Glucosamine
initial concentration: 1.0
is: C00329
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329

http://identifiers.org/biomodels.db/MODEL1310110027#_adaef478_3a19_441b_9bab_356e26278800
is encoded by: hsa:159
boundary condition: true
name: ADSS
is: P30520
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
constant: false

metaR r0734
type: Reaction
reactant: MODEL1310110027#
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110027#
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
kinetic law: MODEL1310110027#

metaR CHOLPtg
is: SBO:0000185
product: MODEL1310110027#
reversible: true
kinetic law: MODEL1310110027#
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - no strong evidence to indicate further lysosomal or golgi metabolism NJ
name: choline phosphate intracellular transport
reactant: MODEL1310110027#

metaM xu5p D c
is: HMDB00868
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:57737
name: D-xylulose 5-phosphate(2-)
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
is: SBO:0000247
initial amount: NaN

metaM itp n
initial concentration: 1.0
is: CHEBI:57614
name: ITP(3-)
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
boundary condition: false
is: HMDB00189
has only substance units: false
is: SBO:0000247
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_63da0bad_2162_43d7_baf9_63c7a1a6ea37
initial concentration: NaN
constant: false
is: P04054
name: PLA2G1B
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:5319

metaR CRNrtx
is described by: ECO:0000134
product: MODEL1310110027#
is: SBO:0000185
name: reversible transport of L-Carnitine in peroxisome
reactant: MODEL1310110027#
reversible: true
kinetic law: MODEL1310110027#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: added during gap filling. NOTES:added during gap filling.

metaR P4503A7r
is version of: http://identifiers.org/ec-code/1.14.14.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (1551.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15579107,PMID:2722762 NOTES:_3 beta hydroxylation of testosterone NJ
name: cytochrome p450 P450 3A7
reversible: false
type: Reaction
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110027#
product: MODEL1310110027#
modifier: MODEL1310110027#
reactant: MODEL1310110027#

metaR FAOXC205C185m
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:5-->C18:5)m
type: Reaction

metaM for e
initial amount: NaN
is: CHEBI:15740
is: SBO:0000247
boundary condition: false
type: Species
constant: false
has only substance units: false
is: HMDB00142
name: formate
initial concentration: 1.0
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058

metaR NACHEXA20ly
name: beta-N-acetylhexosaminidase A, lysosomal
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
product: MODEL1310110027#
reversible: false
reactant: MODEL1310110027#
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110027#
type: Reaction

metaM m2mpdol L c
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C1420H2328N20O320P20 CHARGE: -20
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:28049

metaR r0246
is: SBO:0000176
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.3
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
type: Reaction
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
product: MODEL1310110027#
is described by: ECO:0000000
modifier: MODEL1310110027#
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110027#_6e676e30_a370_496d_ba10_22cc2317060c
has only substance units: false
is: SBO:0000252
is: Q7Z7B1
name: PIGW
initial concentration: NaN
type: Species
is encoded by: hsa:284098
constant: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_908c9d97_9e89_4213_807b_98d28baab52a
is: Q9UIG8
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:28232
name: SLCO3A1
is: SBO:0000252
boundary condition: true

metaR AG13T8g
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110027#
is: SBO:0000176
kinetic law: MODEL1310110027#
fast: false
modifier: MODEL1310110027#
is described by: ECO:0000000
product: MODEL1310110027#
reversible: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149

metaR N2M2NMASNt
name: n2m2nmasn transport, Golgi to extracellular
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110027#
reversible: false
reactant: MODEL1310110027#
is: SBO:0000185
type: Reaction
fast: false

metaM pheacgln e
is: HMDB06344
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:58310
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate

http://identifiers.org/biomodels.db/MODEL1310110027#_e23b54f9_3366_46dd_a605_88ebd1c52da9
boundary condition: true
is encoded by: hsa:AI697028
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
name: _AI697028_1_e

metaM HC02210 e
name: prostaglandin-d3
is: SBO:0000247
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:34939
constant: false
has only substance units: false

metaM lnlccoa m
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5462164
name: linoleic coenzyme A
is: SBO:0000247
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
is: HMDB01064
boundary condition: false
has only substance units: false

metaM 7dhf l
initial concentration: 1.0
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
constant: false
initial amount: NaN
name: heptaglutamyl folate (DHF)
is: HMDB06559
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_6ea395d3_7d61_4446_95f3_0a960698a0b7
name: NDUFAB1
is encoded by: hsa:4706
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
is: O14561
boundary condition: true
type: Species
initial concentration: NaN

metaM pi r
is: HMDB00973
initial concentration: 1.0
is: CHEBI:43474
constant: false
type: Species
initial amount: NaN
is: C00009
is: SBO:0000247
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
name: hydrogenphosphate
has only substance units: false
boundary condition: false

metaR r0735
reactant: MODEL1310110027#
reversible: true
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
product: MODEL1310110027#
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction

metaR S2L2FN2M2MASNtly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110027#
product: MODEL1310110027#
is: SBO:0000185
type: Reaction
fast: false
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110027#
name: s2l2fn2m2masn transport, extracellular to lysosome

metaM udpgal g
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
is: HMDB00302
type: Species
name: UDP-D-galactose(2-)
is: CHEBI:58439
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_1ab10290_6dca_49e2_9653_9b599f215fc9
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:2530
type: Species
is: Q9BYC5
name: FUT8
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR THRGLNNaEx
is: SBO:0000185
reactant: MODEL1310110027#
type: Reaction
product: MODEL1310110027#
name: L-threonine/L-glutamine Na-dependent exchange (Thr-L in)
kinetic law: MODEL1310110027#
reversible: false
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_52217208_4047_4a70_87a3_3724655e213d
is encoded by: hsa:55902
type: Species
boundary condition: true
initial concentration: NaN
constant: false
name: ACSS2
is: SBO:0000252
is: Q5QPH3
has only substance units: false
initial amount: NaN

metaM for c
initial concentration: 1.0
is: CHEBI:15740
initial amount: NaN
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: SBO:0000247
has only substance units: false
name: Formate
type: Species
is: HMDB00142
boundary condition: false
constant: false
is: C00058

metaR r0245
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.3
modifier: MODEL1310110027#
reactant: MODEL1310110027#
type: Reaction
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110027#
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
is: SBO:0000176

metaM pmtcrn x
name: L-palmitoylcarnitine
is: CHEBI:17490
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: HMDB00222
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110027#_254fdf3e_fafb_43a9_99ae_88e9f9323722
name: CAD
is: P27708
constant: false
type: Species
is encoded by: hsa:790
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN

metaR ADK3m
fast: false
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.10
kinetic law: MODEL1310110027#
reversible: true
is described by: ECO:0000269
type: Reaction
product: MODEL1310110027#
reactant: MODEL1310110027#
name: adentylate kinase (GTP)

http://identifiers.org/biomodels.db/MODEL1310110027#_686442c8_ce5e_4259_b50f_cbeda09c0157
constant: false
is: SBO:0000252
name: PLA2G5
is: P39877
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5322
initial amount: NaN
boundary condition: true
type: Species

metaR NADH2 u10m
is described by: ECO:0000134
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
type: Reaction
product: MODEL1310110027#
is: SBO:0000185
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.6.99.3
notes: GENE_ASSOCIATION: (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (4694.1) and (374291.1) and (4728.1) and (4717.1) and (4731.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (4722.1) and (7991.1) and (4541.1) and (4539.1) and (4712.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4706.1) and (4535.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (4712.2) and (4717.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (7991.1) and (4722.1) and (4541.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (126328.1) and (4711.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4729.1) and (4540.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (7991.2) and (4717.1) and (4705.1) and (4725.1) and (4537.1) and (4716.1) and (4722.1) and (4541.1) and (4712.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (374291.1) and (4694.1) and (4728.1) and (4712.2) and (4717.1) and (4731.1) and (…
is version of: http://identifiers.org/ec-code/1.6.5.3
name: NADH dehydrogenase, mitochondrial

metaR GTHRDt
product: MODEL1310110027#
reactant: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#
name: Glutathione transport into mitochondria
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
is: SBO:0000185

metaM dhdascb e
initial amount: NaN
constant: false
is: CHEBI:58070
is: HMDB01264
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
name: dehydroascorbide(1-)

metaM tmndnccoa c
has only substance units: false
is: HMDB06514
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
constant: false
boundary condition: false
type: Species
name: timnodonyl coenzyme A
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_6f6da5f5_5dbe_4dcb_9ffd_a9e519b5b11c
initial concentration: NaN
name: GGT2
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:728441

metaM 3hmbcoa m
has only substance units: false
is: CHEBI:57312
initial amount: NaN
constant: false
initial concentration: 1.0
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
boundary condition: false
type: Species
is: HMDB01356
is: SBO:0000247

metaR AG13T10g
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10331.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
kinetic law: MODEL1310110027#
is: SBO:0000176
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
reactant: MODEL1310110027#
modifier: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_6e890dee_79d2_45e1_9169_cbe9d559dc09
initial concentration: NaN
has only substance units: false
is encoded by: hsa:23539
type: Species
name: SLC16A8
initial amount: NaN
is: SBO:0000252
is: O95907
constant: false
boundary condition: true

metaM dpcoa e
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
has only substance units: false
is: CHEBI:57328
initial concentration: 1.0
constant: false
is: HMDB01373
is: SBO:0000247
is: C00882
initial amount: NaN
name: Dephospho-CoA
type: Species
boundary condition: false

metaR RE2655R
is described by: ECO:0000000
name: RE2655
kinetic law: MODEL1310110027#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
type: Reaction
fast: false
reactant: MODEL1310110027#
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_a586e571_fa34_42ab_a8bd_ed403ec9f11e
constant: false
is encoded by: hsa:1374
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: CPT1A
is: Q8WZ48
initial amount: NaN

metaR GTHP
product: MODEL1310110027#
reversible: true
is described by: ECO:0000134
type: Reaction
is version of: http://identifiers.org/ec-code/1.11.1.12
is version of: http://identifiers.org/ec-code/1.11.1.15
modifier: MODEL1310110027#
reactant: MODEL1310110027#
name: glutathione peroxidase
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.11.1.9
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD

metaR GALU
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.7.9
is described by: ECO:0000134
modifier: MODEL1310110027#
reversible: true
name: UTP-glucose-1-phosphate uridylyltransferase
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (7360.1) or (7359.1) or (7360.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.9 Confidence Level: 0 AUTHORS: PMID:9119383 NOTES:Human Y/N: Y
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_5c59b4fb_378e_4b57_9c9d_276e49071a92
type: Species
is encoded by: hsa:788
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
is: O43772
name: SLC25A20
has only substance units: false
initial amount: NaN

metaR r0497
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
fast: false
modifier: MODEL1310110027#
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
is described by: ECO:0000000
reversible: true
product: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.4.2
reactant: MODEL1310110027#

metaR r2385
modifier: MODEL1310110027#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false
fast: false
is: SBO:0000185
product: MODEL1310110027#
reactant: MODEL1310110027#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110027#

metaR ACACt2
product: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
is described by: ECO:0000269
kinetic law: MODEL1310110027#
reversible: true
modifier: MODEL1310110027#
fast: false
reactant: MODEL1310110027#
name: acetoacetate transport via proton symport
is: SBO:0000185

metaR DHFR
type: Reaction
kinetic law: MODEL1310110027#
reversible: true
product: MODEL1310110027#
is described by: ECO:0000254
reactant: MODEL1310110027#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.3
fast: false
name: dihydrofolate reductase
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:

metaM txa2 c
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
name: thromboxane A2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
is: CHEBI:57445
constant: false
is: HMDB01452

http://identifiers.org/biomodels.db/MODEL1310110027#_78300464_c303_48c8_9605_f8d30677f4a7
is: Q10471
is: SBO:0000252
type: Species
is encoded by: hsa:2590
has only substance units: false
constant: false
name: GALNT2
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR SPODMm
product: MODEL1310110027#
reversible: false
notes: GENE_ASSOCIATION: (6648.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 2 AUTHORS: PMID:12649272,PMID:9376114 NOTES:TV (8-15-2003)
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
fast: false
is: SBO:0000176
is described by: ECO:0000304
name: superoxide dismutase
reactant: MODEL1310110027#
type: Reaction
is version of: http://identifiers.org/ec-code/1.15.1.1

http://identifiers.org/biomodels.db/MODEL1310110027#_a9f09879_74be_4758_b61e_ef11f381243c
initial concentration: NaN
is encoded by: hsa:57786
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is: Q9NYW8
name: RBAK

metaM nac e
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H4NO2 CHARGE: -1
is: C00253
is: HMDB01488
type: Species
is: CHEBI:0
name: Nicotinate
has only substance units: false

metaR TMDPP
product: MODEL1310110027#
type: Reaction
name: thymidine phosphorylase
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (1890.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.4 Confidence Level: 4 AUTHORS: PMID:7028324,PMID:718961,PMID:9693094 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.4
fast: false
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
is: SBO:0000176
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110027#_9b107f29_9d29_4d62_a281_e6874e815450
boundary condition: true
has only substance units: false
type: Species
constant: false
name: MECR
is: SBO:0000252
is encoded by: hsa:51102
initial amount: NaN
is: Q9BV79
initial concentration: NaN

metaR FAOXC61m
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)m
type: Reaction

metaM udpgal e
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
constant: false
is: HMDB00302
type: Species
is: SBO:0000247
boundary condition: false
name: UDP-D-galactose(2-)
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:58439

http://identifiers.org/biomodels.db/MODEL1310110027#_a7a68bda_d804_48d3_aef0_4752e50c1171
constant: false
has only substance units: false
initial amount: NaN
is: O75414
is encoded by: hsa:10201
initial concentration: NaN
type: Species
name: NME6
is: SBO:0000252
boundary condition: true

metaR AG13T7g
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110027#
type: Reaction
reversible: false
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
fast: false
product: MODEL1310110027#
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000

metaR GTHO
is described by: ECO:0000254
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.7
product: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
name: glutathione oxidoreductase
reactant: MODEL1310110027#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#

metaR r2384
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110027#
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
fast: false
is: SBO:0000185

metaR RE1532M
reactant: MODEL1310110027#
product: MODEL1310110027#
fast: false
reversible: true
is: SBO:0000176
name: RE1532
is described by: ECO:0000000
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110027#_4c68db80_f5c1_4ad1_aa05_77ccb8d0067b
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:1345
initial amount: NaN
is: P09669
type: Species
name: COX6C
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110027#_00c6a480_4060_476e_8d4d_36acb428a322
is: SBO:0000252
boundary condition: true
is: Q9NY64
is encoded by: hsa:29988
type: Species
has only substance units: false
name: SLC2A8
constant: false
initial amount: NaN
initial concentration: NaN

metaM prostge1 c
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
name: prostaglandin E1(1-)
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
is: HMDB01442
boundary condition: false
is: CHEBI:57397

http://identifiers.org/biomodels.db/MODEL1310110027#_fd1d29ea_f217_4f3a_b1e3_6865a223c985
boundary condition: true
is encoded by: hsa:6526
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is: P53794
name: SLC5A3
is: SBO:0000252
has only substance units: false

metaM c6dc e
is: HMDB00705
notes: FORMULA: C13H22NO6 CHARGE: -1
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: adipoyl carnitine
constant: false
type: Species
boundary condition: false

metaM hdcoa m
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB06532
name: Hexadecenoyl-CoA (n-C16:1CoA)
is: SBO:0000247
has only substance units: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_eb7af938_1591_4c2e_a948_427197fafdcc
has only substance units: false
name: IMPA1
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is: B7Z6Q4
is: SBO:0000252
is encoded by: hsa:3612
initial amount: NaN

metaM pro D c
initial concentration: 1.0
initial amount: NaN
is: HMDB03411
constant: false
is: SBO:0000247
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
is: CHEBI:16313
type: Species
boundary condition: false
has only substance units: false
name: D-proline

http://identifiers.org/biomodels.db/MODEL1310110027#_00da117d_348b_4329_8df4_05b29c130608
initial amount: NaN
has only substance units: false
is encoded by: hsa:65010
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: SLC26A6
type: Species
constant: false
is: Q548A7

http://identifiers.org/biomodels.db/MODEL1310110027#_573d12df_3dc6_4171_a54a_aa1a19f78d9c
is encoded by: hsa:4645
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
name: MYO5B
is: Q9H6Y6
boundary condition: true

metaR CYTDtn
reversible: true
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
reactant: MODEL1310110027#
name: cytidine transport in nucleus
kinetic law: MODEL1310110027#
type: Reaction
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_e46a5f8a_3f8e_4c6a_a61c_272ab8eeaffc
is encoded by: hsa:AI824319
name: _AI824319_1_r
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
has only substance units: false
initial concentration: NaN

metaR ORNLEUrBATtc
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Ornithine into the cell in exchange for L-Leucine by b0,+AT transporter at the apical surfaces of the membranes of small intestine and renal cells.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_71028231_675f_400b_abec_0b485c1cd491
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:10861
type: Species
boundary condition: true
initial concentration: NaN
name: SLC26A1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110027#_170b48f2_49f4_4c8e_ad61_443311119897
boundary condition: true
name: SLC6A5
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:9152
is: Q9Y345
initial concentration: NaN
initial amount: NaN
constant: false

metaM lys L c
is: HMDB00182
is: SBO:0000247
constant: false
name: L-lysinium(1+)
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: CHEBI:32551
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

metaR DNDPt14m
type: Reaction
product: MODEL1310110027#
is described by: ECO:0000269
is: SBO:0000185
reversible: false
name: dUDP transport via dTDP antiport
kinetic law: MODEL1310110027#
fast: false
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_9585d6a5_e4f6_461e_843f_5557c5f817e8
boundary condition: true
constant: false
is encoded by: hsa:1809
name: DPYSL3
is: Q8IXW6
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_1e982385_92cb_4b5d_afcb_69a3962281ea
is: SBO:0000252
name: PHPT1
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is: Q9P019
is encoded by: hsa:29085
constant: false
initial concentration: NaN

metaR EX orot LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of orotate
type: Reaction

metaR INSt
reversible: true
name: Inosine transport (diffusion)
fast: false
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:AR
modifier: MODEL1310110027#
product: MODEL1310110027#
is: SBO:0000185
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#

metaM nac c
boundary condition: false
notes: FORMULA: C6H4NO2 CHARGE: -1
constant: false
is: SBO:0000247
initial amount: NaN
is: C00253
is: HMDB01488
type: Species
has only substance units: false
name: Nicotinate
is: CHEBI:0
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110027#_255f30fb_23ac_4618_b8d3_0eada6eef438
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is: Q9H999
type: Species
name: PANK3
constant: false
is encoded by: hsa:79646
initial amount: NaN

metaR EX ak2lgchol hs LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-lysoglycerol 3-phosphocholine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_761c72e1_a1ef_4e37_9762_2faba5f7041a
has only substance units: false
is encoded by: hsa:4718
name: NDUFC2
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
is: Q549M5
type: Species

metaM mal L e
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: (S)-malate(2-)
has only substance units: false
is: HMDB00156
initial amount: NaN
is: CHEBI:15589
constant: false
type: Species
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110027#_1fa58051_6fa8_41ee_9769_b5d3ec874e6b
initial concentration: NaN
name: SLC2A9
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:56606
boundary condition: true
is: Q9NRM0

metaR RE3269C
is version of: http://identifiers.org/ec-code/3.1.3.48
is described by: ECO:0000000
name: RE3269
product: MODEL1310110027#
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (8897.1) or (8897.3) or (8897.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:Recin 1 had irreversible version - PI35P3P - GPR from PI35P3P was added - May 2011 IT
fast: false
reactant: MODEL1310110027#
type: Reaction
reversible: true
is: SBO:0000176
modifier: MODEL1310110027#

metaM txa2 e
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
boundary condition: false
initial concentration: 1.0
is: CHEBI:57445
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
is: HMDB01452
has only substance units: false
name: thromboxane A2(1-)

metaM udpgal c
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58439
constant: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
type: Species
is: HMDB00302
boundary condition: false
name: UDP-D-galactose(2-)
initial amount: NaN

metaR HISSNAT5tc
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR r2420
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reversible: true
reactant: MODEL1310110027#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
type: Reaction
is described by: ECO:0000000
product: MODEL1310110027#
kinetic law: MODEL1310110027#

metaM prostge1 e
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
initial amount: NaN
is: CHEBI:57397
boundary condition: false
name: prostaglandin E1(1-)
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
is: HMDB01442

metaR FAOXC121C10x
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C12:1-->C10)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_a441a6c8_0174_418e_a829_4a60eb423e80
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:5330
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
name: PLCB2
is: Q59F77

metaR ALAt2r
reactant: MODEL1310110027#
is described by: ECO:0000304
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
reversible: true
product: MODEL1310110027#
modifier: MODEL1310110027#
name: L-alanine reversible transport via proton symport
is: SBO:0000185
kinetic law: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_3adabe94_cacc_49ec_aa00_906cc4267d05
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:121278
name: TPH2
initial concentration: NaN
is: Q8IWU9
has only substance units: false
boundary condition: true

metaR r2382
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
product: MODEL1310110027#
reversible: false
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185

metaR r1400
fast: false
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
reactant: MODEL1310110027#
name: Active transport
is described by: ECO:0000000
reversible: false
type: Reaction
kinetic law: MODEL1310110027#
is: SBO:0000185

metaR CYSALANaEx
type: Reaction
modifier: MODEL1310110027#
fast: false
is described by: ECO:0000269
reversible: false
product: MODEL1310110027#
is: SBO:0000185
reactant: MODEL1310110027#
name: L-alanine/L-cysteine Na-dependent exchange (Cys-L in)
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

http://identifiers.org/biomodels.db/MODEL1310110027#_c3e8e558_4b37_45bd_8e5c_b5e9c1fdb51f
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:51292
is: SBO:0000252
name: GMPR2
initial amount: NaN

metaM 6dhf m
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
name: hexaglutamyl folate (DHF)
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB06563

metaM c6dc c
is: SBO:0000247
notes: FORMULA: C13H22NO6 CHARGE: -1
boundary condition: false
is: HMDB00705
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
name: adipoyl carnitine
has only substance units: false

metaM vitd3 c
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
name: calciol
initial amount: NaN
type: Species
is: HMDB00876
has only substance units: false
is: CHEBI:28940

http://identifiers.org/biomodels.db/MODEL1310110027#_16016dc7_1d2c_4c9a_86ac_a17bbce78ad7
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: Q9Y5P6
is encoded by: hsa:29925
name: GMPPB
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_688bf4d7_b564_49a4_841b_52532e8b2b6a
boundary condition: true
name: PDE7B
is: Q9NP56
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:27115

metaM dpcoa c
is: HMDB01373
is: C00882
is: CHEBI:57328
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
name: Dephospho-CoA
is: SBO:0000247
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
has only substance units: false
type: Species

metaM oaa m
name: Oxaloacetate
is: CHEBI:16452
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
is: C00036
initial amount: NaN
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
constant: false
is: HMDB00223
is: SBO:0000247

metaM L2aadp6sa c
has only substance units: false
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
is: SBO:0000247
initial concentration: 1.0
is: HMDB01263
boundary condition: false
is: CHEBI:17917
type: Species
constant: false
name: L-allysine
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_3a58c5aa_f8cb_49e8_a876_58dda68af183
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
is: P11168
is encoded by: hsa:6514
type: Species
name: SLC2A2

metaM pro D e
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
name: D-proline
boundary condition: false
has only substance units: false
is: CHEBI:16313
is: HMDB03411
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_8f3df2ab_737f_4376_9160_ba99a2b90eea
type: Species
is encoded by: hsa:4536
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: ND2
constant: false
is: Q7GXY9
has only substance units: false
initial concentration: NaN

metaR FRDPtc
type: Reaction
reversible: true
fast: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110027#
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ

metaM chsterol l
is: HMDB00067
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
name: cholesterol
is: CHEBI:16113
is: SBO:0000247
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187

http://identifiers.org/biomodels.db/MODEL1310110027#_bb80b02d_da88_445c_aa3c_cf14ca9a49ee
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
name: CYP3A7
boundary condition: true
type: Species
is encoded by: hsa:1551
is: P24462

http://identifiers.org/biomodels.db/MODEL1310110027#_05e51330_1801_4845_9852_00b7fe4f08a1
name: _U37519_1_c
initial amount: NaN
is encoded by: hsa:U37519
type: Species
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_13c0dd37_b528_4743_a181_912a9658e59e
boundary condition: true
initial amount: NaN
is: Q15392
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:1718
is: SBO:0000252
type: Species
name: DHCR24

metaM lys L e
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:32551
name: L-lysinium(1+)
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
has only substance units: false
constant: false
is: HMDB00182

metaM m4masn g
name: (alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C46H77N2O35X CHARGE: 0
is: C05881
type: Species

metaR EX glyc LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycerol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_59f97068_e0b3_446d_935a_7b4e548f454c
type: Species
is: P48775
initial concentration: NaN
name: TDO2
constant: false
is encoded by: hsa:6999
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110027#_4d1a2a03_1053_4900_8ae0_6c9956325983
name: SLC24A4
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:123041
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_be89ee6c_0592_4c8b_b187_ce668d7739cf
name: SLC2A1
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is: P11166
type: Species
is encoded by: hsa:6513

metaM xylt c
is: CHEBI:17151
constant: false
name: xylitol
type: Species
is: HMDB02917
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaR GAMt1r
reactant: MODEL1310110027#
type: Reaction
reversible: true
is: SBO:0000185
name: glucosamine transport (uniport)
notes: GENE_ASSOCIATION: (6513.1) or (6517.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:
modifier: MODEL1310110027#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110027#
product: MODEL1310110027#

metaM ksi pre31 g
has only substance units: false
is: HMDB00175
type: Species
boundary condition: false
notes: FORMULA: C227H363N16O189S9X CHARGE: -10
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58053
is: C00130
name: keratan sulfate I biosynthesis, precursor 31
constant: false
is: SBO:0000247

metaR KHte
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
product: MODEL1310110027#
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
name: KHte
fast: false

metaM 6dhf l
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: hexaglutamyl folate (DHF)
is: HMDB06563
is: SBO:0000247
boundary condition: false
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
type: Species
constant: false

metaM arg L e
is: HMDB00517
is: SBO:0000247
initial amount: NaN
is: CHEBI:32682
name: L-argininium(1+)
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
has only substance units: false
boundary condition: false

metaR DOLPH Ler
kinetic law: MODEL1310110027#
product: MODEL1310110027#
is: SBO:0000176
name: Dolichol-phosphate phosphohydrolase, human (liver)
type: Reaction
fast: false
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.3.51 Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:
reactant: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_0d634175_feb3_4abf_a571_03713760175d
type: Species
constant: false
boundary condition: true
is encoded by: hsa:113235
has only substance units: false
name: SLC46A1
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: Q96NT5

http://identifiers.org/biomodels.db/MODEL1310110027#_bb8222cf_6f53_4539_a308_6ca4c60d2c9b
is: Q8NBL9
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:94005
type: Species
constant: false
initial concentration: NaN
boundary condition: true
name: PIGS

http://identifiers.org/biomodels.db/MODEL1310110027#_f27d3829_1869_451d_9bbd_e34d4060fe1e
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:5315
name: PKM2
initial amount: NaN
has only substance units: false
type: Species
is: P14618

metaM glyb c
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
constant: false
is: CHEBI:17750
has only substance units: false
name: glycine betaine
initial concentration: 1.0
type: Species
is: HMDB00043

metaR r1760
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110027#
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
reversible: false
reactant: MODEL1310110027#
modifier: MODEL1310110027#
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110027#_6e882f83_c530_4001_a698_b95f2780f073
is: SBO:0000252
has only substance units: false
is: Q14542
constant: false
name: SLC29A2
initial concentration: NaN
type: Species
is encoded by: hsa:3177
boundary condition: true
initial amount: NaN

metaM chsterol m
constant: false
name: cholesterol
is: CHEBI:16113
initial amount: NaN
is: HMDB00067
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
boundary condition: false
type: Species

metaR r2380
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110027#
kinetic law: MODEL1310110027#
reversible: true
reactant: MODEL1310110027#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

metaM 3mgcoa m
is: CHEBI:57346
initial concentration: 1.0
is: HMDB01057
notes: FORMULA: C27H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C27H42N7O19P3S/c1-14(8-17(36)37)9-18(38)57-7-6-29-16(35)4-5-30-25(41)22(40)27(2,3)11-50-56(47,48)53-55(45,46)49-10-15-21(52-54(42,43)44)20(39)26(51-15)34-13-33-19-23(28)31-12-32-24(19)34/h8,12-13,15,20-22,26,39-40H,4-7,9-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,45,46)(H,47,48)(H2,28,31,32)(H2,42,43,44)/p-5/b14-8+/t15-,20-,21-,22+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01081 EHMN_ABBREVIATION: C03231
type: Species
boundary condition: false
has only substance units: false
name: trans-3-methylglutaconyl-CoA(5-)
constant: false
initial amount: NaN
is: SBO:0000247

metaR RE2677E
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:IT - fixed proton
fast: false
type: Reaction
product: MODEL1310110027#
kinetic law: MODEL1310110027#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110027#
name: RE2677

http://identifiers.org/biomodels.db/MODEL1310110027#_64932a66_88ab_45d1_82af_66f117867116
boundary condition: true
type: Species
initial concentration: NaN
name: PIK3R1
has only substance units: false
is encoded by: hsa:5295
is: SBO:0000252
constant: false
initial amount: NaN
is: B3KT19

metaR C226CPT1
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
name: carnitine C22:6 transferase
product: MODEL1310110027#
is described by: ECO:0000000
fast: false
reversible: false
reactant: MODEL1310110027#

metaM mi145p c
constant: false
is: HMDB01498
is: SBO:0000247
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1 EHMN_ABBREVIATION: C01245
initial concentration: 1.0
boundary condition: false
is: CHEBI:203600
initial amount: NaN
has only substance units: false
name: 1D-myo-inositol 1,4,5-trisphosphate(6-)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_fcdb0e86_ab9c_48fb_894b_96dbbd852abc
has only substance units: false
is encoded by: hsa:4702
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: NDUFA8
constant: false
is: B1AM93

metaR EX tymsf LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Tyramine O-sulfate exchange
type: Reaction

metaM 34dhoxmand m
has only substance units: false
name: 3,4-Dihydroxymandelate
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:27637
is: HMDB01866
constant: false
type: Species
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_86633caf_2c24_4b03_8ccf_9a043211470e
is: SBO:0000252
is: Q5JT09
has only substance units: false
boundary condition: true
is encoded by: hsa:83549
initial amount: NaN
initial concentration: NaN
name: UCK1
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_be08014e_b0eb_46dd_9dc8_09822e55f37c
boundary condition: true
is: P21912
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:6390
name: SDHB
initial amount: NaN

metaR ACACT1x
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:11108725 NOTES:NCD NJ - added peroxisomal version
type: Reaction
is described by: ECO:0000134
product: MODEL1310110027#
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
name: acetyl-CoA C-acetyltransferase, mitochondrial
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.9
reversible: false
reactant: MODEL1310110027#
is: SBO:0000176

metaR RE1518M
kinetic law: MODEL1310110027#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.3.3.6
product: MODEL1310110027#
modifier: MODEL1310110027#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is: SBO:0000176
name: RE1518
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.3.99.13
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_2837491a_eee3_42da_af77_b4170d3717b8
is: P59796
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:257202
has only substance units: false
name: GPX6
type: Species
initial concentration: NaN
initial amount: NaN

metaM tag hs c
constant: false
initial concentration: 1.0
is: SBO:0000247
name: triglyceride
type: Species
is: CHEBI:17855
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0

metaR CORE3GTg
name: Core 3 beta-GlcNAc-transferase, Golgi apparatus
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
is: SBO:0000176
notes: GENE_ASSOCIATION: (192134.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.147 Confidence Level: 0 AUTHORS: PMID:11821425 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110027#
modifier: MODEL1310110027#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110027#_ffc29e11_0fed_482e_b47d_5f11af65edaa
has only substance units: false
is encoded by: hsa:3294
is: SBO:0000252
constant: false
type: Species
is: P37059
initial amount: NaN
initial concentration: NaN
name: HSD17B2
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110027#_0b703138_4cf4_4223_804d_b15bb7c1987c
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
name: GALNS
is: P34059
is: SBO:0000252
constant: false
is encoded by: hsa:2588

metaM arg L c
name: L-argininium(1+)
is: HMDB00517
is: CHEBI:32682
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
constant: false
boundary condition: false

metaM dudp n
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
initial amount: NaN
name: dUDP(3-)
type: Species
is: HMDB01000
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:60471

metaR C226CPT2
product: MODEL1310110027#
reactant: MODEL1310110027#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
modifier: MODEL1310110027#
fast: false
name: C226 transport into the mitochondria
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:TDV
kinetic law: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_9bb3336a_8d15_42f0_baf4_4026109b2257
type: Species
is: P51687
is encoded by: hsa:6821
name: SUOX
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false

metaR RE1447N
product: MODEL1310110027#
name: RE1447
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
reactant: MODEL1310110027#
reversible: true
kinetic law: MODEL1310110027#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
fast: false

metaR RE2079R
is: SBO:0000176
reactant: MODEL1310110027#
reversible: true
name: RE2079
is described by: ECO:0000000
product: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
type: Reaction
kinetic law: MODEL1310110027#

metaM nm4masn g
constant: false
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
is: C05882
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C54H90N3O40X CHARGE: 0
type: Species
initial amount: NaN

metaR r1871
type: Reaction
kinetic law: MODEL1310110027#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000000
reversible: false
fast: false
product: MODEL1310110027#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110027#_9955f28a_8e51_4250_bb57_6cf46c83b5a6
has only substance units: false
constant: false
is: SBO:0000252
is: Q9NRA2
type: Species
is encoded by: hsa:26503
name: SLC17A5
initial amount: NaN
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110027#_a28f4d0b_64af_482c_ab79_3bdfe7ffbaad
is: Q6PXP3
is: SBO:0000252
name: SLC2A7
has only substance units: false
constant: false
is encoded by: hsa:155184
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species

metaM frdp r
is: CHEBI:175763
initial concentration: 1.0
is: C00448
constant: false
initial amount: NaN
is: HMDB00961
type: Species
name: Farnesyl diphosphate
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448

metaR ALAt4
is described by: ECO:0000269
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (54407.1) or (6542.1) or (11254.1) or (6541.1) or (81539.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:tv Mendz pg. 201 Reversibility is unclear.
reversible: false
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
product: MODEL1310110027#
name: Alanine-Sodium symporter
fast: false
is: SBO:0000185
type: Reaction

metaM itp e
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
boundary condition: false
is: SBO:0000247
is: HMDB00189
is: CHEBI:57614
initial concentration: 1.0
has only substance units: false
type: Species
name: ITP(3-)
constant: false
initial amount: NaN

metaM 3hibutcoa m
initial concentration: 1.0
is: CHEBI:28259
boundary condition: false
is: HMDB01052
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
name: (S)-3-Hydroxyisobutyryl-CoA
type: Species

metaR RE0453C
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
name: RE0453
is: SBO:0000176
product: MODEL1310110027#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110027#_58250972_b5cd_48e2_8739_7eca004eb8df
has only substance units: false
is encoded by: hsa:2517
boundary condition: true
name: FUCA1
is: P04066
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_1fdff9b7_0d94_4150_9971_aeeab0f2dbc1
initial concentration: NaN
name: SLC12A4
is: F5H066
type: Species
is: SBO:0000252
is encoded by: hsa:6560
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN

metaR EX pchol hs LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphatidylcholine (homo sapiens) exchange
type: Reaction

metaM 4abut e
boundary condition: false
is: HMDB00112
is: CHEBI:3628
name: 4-Aminobutanoate
type: Species
initial amount: NaN
initial concentration: 1.0
is: C00334
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C4H9NO2 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110027#_e9820d4e_9042_41f5_8715_bd4379fba232
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: _AI620219_1_m
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AI620219
type: Species

metaM Lkynr c
boundary condition: false
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
name: L-kynurenine
is: CHEBI:16946
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
is: HMDB00684

metaM dudp m
type: Species
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB01000
boundary condition: false
is: CHEBI:60471
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
initial amount: NaN
name: dUDP(3-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110027#_368111d4_789c_419c_955b_9e5d4798857b
boundary condition: true
is: SBO:0000252
constant: false
name: ACSS1
has only substance units: false
is encoded by: hsa:84532
is: Q9NUB1
type: Species
initial amount: NaN
initial concentration: NaN

metaR RE1447M
is: SBO:0000176
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.3.1.41
product: MODEL1310110027#
fast: false
reactant: MODEL1310110027#
reversible: true
kinetic law: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
name: RE1447
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110027#_b8b6203e_33bb_4d7f_8d86_447c7123b103
initial amount: NaN
is: SBO:0000252
is: P23921
is encoded by: hsa:6240
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
name: RRM1
type: Species

metaR r1636
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110027#
fast: false
product: MODEL1310110027#
modifier: MODEL1310110027#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110027#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR ACGPID
reactant: MODEL1310110027#
product: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (9487.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.5.1.89 Confidence Level: 4 AUTHORS: PMID:10085243,PMID:14742432 NOTES:NCD
modifier: MODEL1310110027#
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.89
is: SBO:0000176
name: N-acetylglucosaminylphosphatidylinositol deacetylase
reversible: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110027#_26662f91_a1f6_4190_9c74_c1cc9312234f
initial concentration: NaN
is: E7EPT3
type: Species
name: ALDH7A1
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:501
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_2756e5bc_09bf_4225_86a1_47ef44f7d980
constant: false
initial amount: NaN
has only substance units: false
name: IDH2
initial concentration: NaN
is: P48735
is encoded by: hsa:3418
type: Species
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110027#_33574410_c447_404e_ab36_0e25a477ab0a
has only substance units: false
initial concentration: NaN
is: Q8IZH9
type: Species
initial amount: NaN
name: GCH1
boundary condition: true
is encoded by: hsa:2643
is: SBO:0000252
constant: false

metaM tag hs e
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:17855
name: triglyceride
boundary condition: false
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
initial concentration: 1.0
type: Species

metaM dcyt c
type: Species
is: HMDB00014
is: SBO:0000247
boundary condition: false
is: C00881
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:15698
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
name: Deoxycytidine
has only substance units: false

metaR ETHAK
is version of: http://identifiers.org/ec-code/2.7.1.82
product: MODEL1310110027#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
name: Ethanolamine kinase
is version of: http://identifiers.org/ec-code/2.7.1.32
reversible: false
notes: GENE_ASSOCIATION: (1119.2) or (55500.1) or (1119.1) or (55224.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.82 Confidence Level: 4 AUTHORS: NOTES:NCD
fast: false
is: SBO:0000176
modifier: MODEL1310110027#

metaM ribflv e
is: C00255
has only substance units: false
is: SBO:0000247
is: HMDB00244
boundary condition: false
constant: false
name: Riboflavin
is: CHEBI:3554
notes: FORMULA: C17H20N4O6 CHARGE: 0
initial amount: NaN
type: Species
initial concentration: 1.0

metaM dpcoa m
is: HMDB01373
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
name: 3'-dephospho-CoA(2-)
type: Species
has only substance units: false
is: CHEBI:57328
is: SBO:0000247
initial concentration: 1.0

metaM C04849 e
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
has only substance units: false
type: Species
is: CHEBI:57449
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaR OCDCAtr
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110027#
is described by: ECO:0000000
reactant: MODEL1310110027#
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110027#
name: fatty acid transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110027#_dc70564a_c21d_42f4_9543_f51886bc81ce
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
name: BAAT
type: Species
has only substance units: false
is: Q14032
is encoded by: hsa:570
boundary condition: true

metaR RE0453N
is: SBO:0000176
fast: false
modifier: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110027#
product: MODEL1310110027#
name: RE0453

metaR FPGS4m
modifier: MODEL1310110027#
name: folylpolyglutamate synthetase (DHF), mitochondrial
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT
type: Reaction
fast: false
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/6.3.2.17
product: MODEL1310110027#
is described by: ECO:0000000
reactant: MODEL1310110027#
is: SBO:0000176
reversible: false

metaR ACGAM6PSi
reversible: false
name: N-acetylglucosamine-6-phosphate synthase
product: MODEL1310110027#
is: SBO:0000176
notes: GENE_ASSOCIATION: (64841.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.3.1.4 Confidence Level: 2 AUTHORS: NOTES:NCD
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.3.1.4
fast: false
reactant: MODEL1310110027#
is described by: ECO:0000304
kinetic law: MODEL1310110027#
type: Reaction

metaR r1978
product: MODEL1310110027#
reversible: false
is: SBO:0000185
name: Y+LAT2 Utilized transport
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
is described by: ECO:0000000
modifier: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_1568e652_1fa5_4acb_a456_f0025dca6284
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:55350
has only substance units: false
type: Species
is: SBO:0000252
name: VNN3

http://identifiers.org/biomodels.db/MODEL1310110027#_78ce7dda_7a27_4a7a_8677_50902c50cda1
type: Species
constant: false
name: B3GNT6
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:192134
is: A8K9Q8
has only substance units: false
boundary condition: true

metaR NAt3 1
notes: GENE_ASSOCIATION: (389015.1) or (6548.1) or (6550.1) or (6549.1) or (6553.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:7759094,PMID:8199403,PMID:8595899,PMID:9933641 NOTES:JLR
is: SBO:0000185
modifier: MODEL1310110027#
reactant: MODEL1310110027#
type: Reaction
product: MODEL1310110027#
fast: false
reversible: true
name: sodium proton antiporter (H:NA is 1:1)
is described by: ECO:0000269
kinetic law: MODEL1310110027#

metaM gua e
name: guanine
is: HMDB00132
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
constant: false
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:16235

http://identifiers.org/biomodels.db/MODEL1310110027#_9ee0678c_1166_4cb2_b25e_354d232ef664
initial concentration: NaN
is: P04844
is encoded by: hsa:6185
initial amount: NaN
boundary condition: true
name: RPN2
type: Species
has only substance units: false
is: SBO:0000252
constant: false

metaR THRALANaEx
is described by: ECO:0000269
product: MODEL1310110027#
fast: false
reactant: MODEL1310110027#
name: L-alanine/L-threonine Na-dependent exchange (Thr-L in)
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
type: Reaction

metaM HC01496 m
type: Species
name: 2-Amino-3-oxoadipate
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
is: SBO:0000247
constant: false
is: CHEBI:28095
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaM 4abut c
is: CHEBI:3628
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C4H9NO2 CHARGE: 0
is: C00334
is: HMDB00112
name: 4-Aminobutanoate
initial amount: NaN

metaR THRCYSNaEx
fast: false
reactant: MODEL1310110027#
is: SBO:0000185
kinetic law: MODEL1310110027#
type: Reaction
reversible: false
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110027#
name: L-cysteine/L-threonine Na-dependent exchange (Thr-L in)
is described by: ECO:0000269

metaR HIStiDF
notes: GENE_ASSOCIATION: (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754 NOTES:SAB
is: SBO:0000185
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
reversible: false
name: L-histidine transport via diffusion (extracellular to cytosol)
is described by: ECO:0000269
reactant: MODEL1310110027#
product: MODEL1310110027#
type: Reaction
fast: false

metaR EX trp L LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tryptophan exchange
type: Reaction

metaM 5aizc c
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
is: HMDB06273
type: Species
initial concentration: 1.0
is: C04751
initial amount: NaN
is: CHEBI:58564
has only substance units: false
notes: FORMULA: C9H11N3O9P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01347 EHMN_ABBREVIATION: C04751
is: SBO:0000247
boundary condition: false
constant: false

metaR BMTer L
is: SBO:0000176
notes: GENE_ASSOCIATION: (9488.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8861954 NOTES:NCD
reactant: MODEL1310110027#
reversible: false
fast: false
name: B mannosyltransferase, endoplasmic reticulum
is described by: ECO:0000000
kinetic law: MODEL1310110027#
product: MODEL1310110027#
modifier: MODEL1310110027#
type: Reaction

metaM ksii core4 pre7 g
notes: FORMULA: C75H121N6O56SX CHARGE: -2
name: keratan sulfate II biosynthesis, precursor 7
boundary condition: false
has only substance units: false
is: SBO:0000247
is: C00130
is: HMDB00175
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:58053

metaR GLYC3Ptmc
fast: false
is: SBO:0000185
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: added during gap filling. No evidence found for such a reaction. NOTES:added during gap filling. No evidence found for such a reaction.
kinetic law: MODEL1310110027#
type: Reaction
reactant: MODEL1310110027#
name: glycerol-3-phopshate transport, cytoplasm
product: MODEL1310110027#
reversible: true

metaR RE0453M
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110027#
product: MODEL1310110027#
name: RE0453
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
fast: false
modifier: MODEL1310110027#

metaR FAOXOHMC10DC10c
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(w-OHMC10-->DC10)c
type: Reaction

metaR EX 4nphsf LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenyl sulfate exchange
type: Reaction

metaM itp c
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
name: ITP(3-)
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
is: HMDB00189
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:57614

metaR r1635
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
fast: false
modifier: MODEL1310110027#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110027#
kinetic law: MODEL1310110027#
is described by: ECO:0000000
reactant: MODEL1310110027#

metaR EX glysar LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycylsarcosine
type: Reaction

metaR KSII CORE4tly
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: keratan sulfate II (core 4) transport, extracellular to lysosome
product: MODEL1310110027#
reactant: MODEL1310110027#
is: SBO:0000185
fast: false
reversible: false
kinetic law: MODEL1310110027#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110027#_c1a2fb3d_a315_4a13_9545_13ba16899503
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:37
initial concentration: NaN
is: P49748
name: ACADVL
type: Species
is: SBO:0000252
initial amount: NaN

metaM gpi prot hs r
initial amount: NaN
notes: FORMULA: C55H106N4O38P4FULLRCO2FULLR2CO2X CHARGE: 0
boundary condition: false
constant: false
name: {[(Prot-PE-Man),(PE)-Man],[PE]}-Man-GlcN-acylPI
is: HMDB00220
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:7896
is: C00249
has only substance units: false

metaR S6T17g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
fast: false
product: MODEL1310110027#
reversible: false
reactant: MODEL1310110027#
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#

metaR FAEL183
kinetic law: MODEL1310110027#
fast: false
modifier: MODEL1310110027#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
name: fatty-acyl-CoA elongation (n-C18:3CoA)
product: MODEL1310110027#
type: Reaction

metaM pmtcrn c
initial amount: NaN
is: CHEBI:17490
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: HMDB00222
has only substance units: false
boundary condition: false
name: L-palmitoylcarnitine

metaR EX vacc LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: vaccenic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_b96b7872_a1f1_422d_b4a0_18a2a6fc7f07
name: COX4I2
constant: false
is: Q96KJ9
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:84701
is: SBO:0000252
boundary condition: true
type: Species

metaR PPItm
product: MODEL1310110027#
is described by: ECO:0000134
reactant: MODEL1310110027#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
is: SBO:0000185
kinetic law: MODEL1310110027#
name: diphopshate transporter, mitochondrial
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_fe26af8f_b91b_401c_bd90_ca3a7a701c5d
type: Species
initial amount: NaN
is: Q68CJ7
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:131669
name: UROC1
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110027#_e88f8787_2a56_4db5_b5dd_52fd45d31bbe
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
type: Species
name: PKLR
is encoded by: hsa:5313
initial amount: NaN
initial concentration: NaN

metaM dcyt e
initial amount: NaN
is: CHEBI:15698
is: HMDB00014
type: Species
is: SBO:0000247
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
initial concentration: 1.0
name: Deoxycytidine
is: C00881
has only substance units: false
boundary condition: false
constant: false

metaR r1634
kinetic law: MODEL1310110027#
fast: false
is: SBO:0000185
product: MODEL1310110027#
is described by: ECO:0000000
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction

metaM glcur r
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: HMDB00127
name: D-glucuronate
type: Species
constant: false
is: CHEBI:15748
initial concentration: 1.0

metaR EX Rtotal3 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 3 position exchange
type: Reaction

metaM ribflv c
name: Riboflavin
initial amount: NaN
constant: false
is: C00255
is: CHEBI:3554
has only substance units: false
type: Species
is: HMDB00244
notes: FORMULA: C17H20N4O6 CHARGE: 0
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaR DM pe hs LPAREN r RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pe_hs[r]
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_c8dc8d3e_58f1_490b_ad34_e5e9a5bf30d2
is: Q8IVA8
type: Species
has only substance units: false
is encoded by: hsa:2571
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: GAD1
initial concentration: NaN
constant: false

metaM gua c
is: CHEBI:16235
initial concentration: 1.0
is: HMDB00132
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
is: C00242
name: Guanine
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_d74bf4a5_8d0a_4001_a6a9_1f149931e9dc
constant: false
is: Q59EH3
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:52
type: Species
name: ACP1
initial concentration: NaN
initial amount: NaN

metaR FAEL184
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
fast: false
name: fatty-acyl-CoA elongation (n-C20:4CoA)
reversible: false
modifier: MODEL1310110027#
product: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#

metaR CYSGLTH
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
name: Glutathione:cystine oxidoreductase
product: MODEL1310110027#
reversible: true
reactant: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#
fast: false
is: SBO:0000176

metaR 7DHCHSTEROLtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is described by: ECO:0000000
kinetic law: MODEL1310110027#
reversible: true
type: Reaction
name: cholesterol precursor intracellular transport
fast: false
product: MODEL1310110027#
is: SBO:0000185
reactant: MODEL1310110027#

metaR CYSASNNaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110027#
type: Reaction
modifier: MODEL1310110027#
reversible: false
kinetic law: MODEL1310110027#
is described by: ECO:0000269
fast: false
name: L-cysteine/L-asparagine Na-dependent exchange (Cys-L in)
reactant: MODEL1310110027#
is: SBO:0000185

metaM succoa m
is: HMDB01022
constant: false
name: Succinyl-CoA
initial concentration: 1.0
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
boundary condition: false
is: CHEBI:57292
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_082456d4_37a4_4754_ae36_10e1c58e12b4
boundary condition: true
name: ECI2
has only substance units: false
type: Species
is: O75521
initial amount: NaN
is encoded by: hsa:10455
is: SBO:0000252
initial concentration: NaN
constant: false

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_64e8db5c_d545_46e8_a6a9_0c53633e0367
is: P05091
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: ALDH2
is encoded by: hsa:217
type: Species
constant: false
boundary condition: true

metaM chsterol c
boundary condition: false
is: SBO:0000247
is: CHEBI:16113
constant: false
type: Species
name: cholesterol
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
is: HMDB00067

metaM trdrd m
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:15967
name: Reduced thioredoxin
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
type: Species
boundary condition: false

metaR r1633
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110027#
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110027#
type: Reaction
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR EX hdcea LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecenoate (n-C16:1)
type: Reaction

metaR DTTPtn
reversible: true
name: dTTP diffusion in nucleus
fast: false
kinetic law: MODEL1310110027#
is described by: ECO:0000000
reactant: MODEL1310110027#
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185
type: Reaction

metaM HC01609 e
is: CHEBI:28766
initial concentration: 1.0
constant: false
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
has only substance units: false
name: UroporphyrinogenI
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN

metaR GALt4
kinetic law: MODEL1310110027#
product: MODEL1310110027#
type: Reaction
modifier: MODEL1310110027#
name: galactose transport via sodium symport
reactant: MODEL1310110027#
reversible: true
is described by: ECO:0000269
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110027#_2eb60ce1_66d2_4778_985f_fbc06ca9a0ed
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is: O60658
is encoded by: hsa:5151
constant: false
initial concentration: NaN
name: PDE8A
is: SBO:0000252

metaM gal e
is: CHEBI:0
notes: FORMULA: C6H12O6 CHARGE: 0
type: Species
name: D-Galactose
is: C00124
boundary condition: false
is: SBO:0000247
is: HMDB00143
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_1dcf7bbf_cd8a_428e_937c_419a4bebd680
is encoded by: hsa:23563
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
name: CHST5
boundary condition: true
has only substance units: false

metaM lys L m
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00182
name: L-lysinium(1+)
is: CHEBI:32551
type: Species

metaM ala B m
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
is: HMDB00056
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
constant: false
initial concentration: 1.0
name: beta-alanine
is: CHEBI:16958

metaM dgtp c
is: HMDB01440
initial concentration: 1.0
constant: false
name: dGTP
initial amount: NaN
is: SBO:0000247
is: CHEBI:16497
is: C00286
has only substance units: false
boundary condition: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
type: Species

metaR FAOXC226m
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:6)m
type: Reaction

metaM dtdp n
initial concentration: 1.0
is: HMDB01274
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
has only substance units: false
is: CHEBI:58369
boundary condition: false
type: Species
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
constant: false
is: SBO:0000247
initial amount: NaN

metaR L LACt2r
kinetic law: MODEL1310110027#
name: L-lactate reversible transport via proton symport
reactant: MODEL1310110027#
fast: false
modifier: MODEL1310110027#
type: Reaction
reversible: true
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD

metaM mal L c
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
type: Species
is: HMDB00156
initial amount: NaN
boundary condition: false
name: (S)-malate(2-)
is: CHEBI:15589
has only substance units: false

metaR RE1521M
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110027#
name: RE1521
is: SBO:0000176
modifier: MODEL1310110027#
is described by: ECO:0000000
reactant: MODEL1310110027#
product: MODEL1310110027#

metaR RE3272N
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
type: Reaction
name: RE3272
reversible: true
product: MODEL1310110027#
fast: false
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_30216ce0_293d_4df2_a6c2_3fd518b19c2b
is: SBO:0000252
has only substance units: false
name: LDHA
boundary condition: true
initial amount: NaN
is encoded by: hsa:3939
type: Species
constant: false
initial concentration: NaN
is: P00338

metaM akg m
is: CHEBI:16810
boundary condition: false
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
name: 2-Oxoglutarate
is: C00026
constant: false
is: HMDB00208
initial concentration: 1.0

metaR BHBt
name: (R)-3-Hydroxybutanoate transport via H+ symport
kinetic law: MODEL1310110027#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
type: Reaction
is described by: ECO:0000000
product: MODEL1310110027#
reactant: MODEL1310110027#
fast: false
is: SBO:0000185

metaR r1632
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
modifier: MODEL1310110027#
reversible: true
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_bc5a6a04_4e70_4cea_87e4_dd33a3ac4bc3
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q38G75
has only substance units: false
name: GALE
is encoded by: hsa:2582
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_35b677b1_8537_440a_b4e5_e32bb29a84d5
initial amount: NaN
name: GLRX2
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:51022
constant: false
has only substance units: false
is: Q9NS18
boundary condition: true
type: Species

metaR DNDPt8m
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dADP transport via dUDP antiport
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
product: MODEL1310110027#
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
fast: false
modifier: MODEL1310110027#

metaR r2389
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110027#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110027#
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110027#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110027#
fast: false

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

metaM coa x
is: HMDB01423
is: C00010
has only substance units: false
name: Coenzyme A
initial concentration: 1.0
constant: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
initial amount: NaN
is: CHEBI:57287
boundary condition: false
is: SBO:0000247
type: Species

metaM succ c
is: HMDB00254
boundary condition: false
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: SBO:0000247
is: CHEBI:30031
initial amount: NaN
type: Species
name: Succinate
initial concentration: 1.0
is: C00042
constant: false
has only substance units: false

metaM lthstrl r
type: Species
boundary condition: false
is: HMDB01170
name: 5alpha-cholest-7-en-3beta-ol
constant: false
has only substance units: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189
initial amount: NaN
is: CHEBI:17168
is: SBO:0000247
initial concentration: 1.0

metaR EX aprgstrn LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 20alpha-Hydroxyprogesterone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_41ec50ad_824e_4f07_a8e4_346610071960
is encoded by: hsa:2880
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
constant: false
name: GPX5
has only substance units: false
is: O75715
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_b6b62f16_e2a5_4763_8dd2_471ea7df0bb8
name: GMDS
is: SBO:0000252
is: O60547
boundary condition: true
type: Species
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2762

http://identifiers.org/biomodels.db/MODEL1310110027#_044ce786_233c_41d2_9c13_f25f6e2e79d6
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
is: P78542
name: HK1
is encoded by: hsa:3098

metaM oaa c
name: Oxaloacetate
initial concentration: 1.0
has only substance units: false
is: C00036
is: CHEBI:3338
is: HMDB00223
is: SBO:0000247
boundary condition: false
notes: FORMULA: C4H2O5 CHARGE: -2
type: Species
initial amount: NaN
constant: false

metaM aps c
name: 5'-adenylyl sulfate(2-)
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB01003
constant: false
notes: FORMULA: C10H12N5O10PS CHARGE: -2 INCHI: InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00204 EHMN_ABBREVIATION: C00224
type: Species
boundary condition: false
is: CHEBI:58243

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

metaR r1768
type: Reaction
kinetic law: MODEL1310110027#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110027#
reversible: false
modifier: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110027#
is described by: ECO:0000000

metaM cdp e
name: CDP(3-)
is: HMDB01546
constant: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:58069

metaR GULNDer
type: Reaction
kinetic law: MODEL1310110027#
is: SBO:0000176
product: MODEL1310110027#
name: gulonate dehydrogenase, endoplasmic reticulum
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.19 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD
fast: false
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110027#_0bfa2479_b92a_4c30_a937_4504fcdf9d66
is encoded by: hsa:6389
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
name: SDHA
is: P31040

metaM 44mctr r
has only substance units: false
is: CHEBI:17813
initial amount: NaN
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
constant: false
initial concentration: 1.0
type: Species
is: HMDB01023
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
is: SBO:0000247
boundary condition: false

metaR r1631
is described by: ECO:0000000
reactant: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110027#
product: MODEL1310110027#

metaR CITL
is: SBO:0000176
reactant: MODEL1310110027#
fast: false
kinetic law: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
is described by: ECO:0000000
product: MODEL1310110027#
modifier: MODEL1310110027#
name: Citrate lyase
reversible: false

metaM arg L m
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:32682
constant: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
type: Species
has only substance units: false
is: HMDB00517
name: L-argininium(1+)
initial concentration: 1.0

metaR RE3556C
is described by: ECO:0000000
is: SBO:0000176
fast: false
product: MODEL1310110027#
reactant: MODEL1310110027#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
name: RE3556
type: Reaction
kinetic law: MODEL1310110027#

metaR HMGLm
product: MODEL1310110027#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3155.1) or (54511.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11129331 NOTES:TV
reversible: false
fast: false
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
reactant: MODEL1310110027#
type: Reaction
name: hydroxymethylglutaryl-CoA lyase
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/4.1.3.4

metaM ca2 c
initial amount: NaN
is: HMDB00464
boundary condition: false
initial concentration: 1.0
name: calcium(2+)
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
is: CHEBI:29108
has only substance units: false
constant: false
is: SBO:0000247
type: Species

metaR GMPR
modifier: MODEL1310110027#
name: GMP reductase
notes: GENE_ASSOCIATION: (2766.1) or (51292.1) or (51292.3) or (51292.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.1.7 Confidence Level: 4 AUTHORS: PMID:12009299,PMID:8188226 NOTES:
reversible: false
product: MODEL1310110027#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110027#
is described by: ECO:0000269
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.7.1.7
type: Reaction

metaM ocdcea e
name: octadecenoate (n-C18:1)
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB00207
initial amount: NaN
is: CHEBI:0
has only substance units: false
is: C00712
notes: FORMULA: C18H33O2 CHARGE: -1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_37bb91aa_b0cd_4407_a2ef_663b747fcda6
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
has only substance units: false
name: CMAS
is encoded by: hsa:55907
is: Q8NFW8
boundary condition: true
initial amount: NaN

metaM chsterol e
constant: false
type: Species
is: CHEBI:16113
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
name: cholesterol
is: HMDB00067
has only substance units: false
initial concentration: 1.0

metaR r2388
kinetic law: MODEL1310110027#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
modifier: MODEL1310110027#
reversible: false
reactant: MODEL1310110027#
product: MODEL1310110027#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110027#_266323a5_140b_41a9_880a_6847206fdcf3
type: Species
name: _286297_1_c
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:286297
has only substance units: false

metaR ALATHRNaEx
is described by: ECO:0000269
product: MODEL1310110027#
type: Reaction
modifier: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
name: L-alanine/L-threonine Na-dependent exchange (Ala-L in)
reversible: false
kinetic law: MODEL1310110027#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110027#_0417a1ec_a48c_4df5_8afe_8ca4e57663eb
initial amount: NaN
is: SBO:0000252
name: CBR1
has only substance units: false
boundary condition: true
is: P16152
constant: false
is encoded by: hsa:873
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_8b295a24_0121_4c24_b61e_a7f7a762082a
is: Q9UPY5
boundary condition: true
has only substance units: false
constant: false
name: SLC7A11
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:23657
type: Species
initial amount: NaN

metaR CLPNDCOAtx
is: SBO:0000185
fast: false
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
name: fatty acid intracellular transport
is described by: ECO:0000000
type: Reaction
reversible: true

metaR RE1903R
reactant: MODEL1310110027#
reversible: true
product: MODEL1310110027#
type: Reaction
fast: false
kinetic law: MODEL1310110027#
name: RE1903
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110027#_f7df85d6_7523_4c7f_89b6_9194270da2cf
is encoded by: hsa:8394
is: SBO:0000252
name: PIP5K1A
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is: Q99755
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_09128e1f_58d5_404c_9477_a916890fbc91
initial concentration: NaN
name: DGKZ
type: Species
is: SBO:0000252
boundary condition: true
is: B7Z2M9
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:8525

http://identifiers.org/biomodels.db/MODEL1310110027#_8807a2d8_861e_4254_bc86_be21db6d3126
type: Species
is: Q16842
has only substance units: false
is encoded by: hsa:6483
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: ST3GAL2
constant: false

metaM gal c
name: D-Galactose
type: Species
is: C00124
is: SBO:0000247
is: CHEBI:0
has only substance units: false
constant: false
is: HMDB00143
notes: FORMULA: C6H12O6 CHARGE: 0
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaM dgtp e
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: dGTP
is: CHEBI:16497
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: HMDB01440
has only substance units: false
type: Species
boundary condition: false

metaR r0022
is described by: ECO:0000000
modifier: MODEL1310110027#
is: SBO:0000176
kinetic law: MODEL1310110027#
reversible: true
fast: false
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
reactant: MODEL1310110027#
type: Reaction
is version of: http://identifiers.org/ec-code/1.8.1.7
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7

metaM gchola x
notes: FORMULA: C26H43NO6 CHARGE: 0 INCHI: InChI=1S/C26H43NO6/c1-14(4-7-22(31)27-13-23(32)33)17-5-6-18-24-19(12-21(30)26(17,18)3)25(2)9-8-16(28)10-15(25)11-20(24)29/h14-21,24,28-30H,4-13H2,1-3H3,(H,27,31)(H,32,33)/p-1/t14-,15+,16-,17-,18+,19+,20-,21+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:58235
name: glycocholate
is: HMDB00138
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false

metaM b2coa m
is: SBO:0000247
is: HMDB02009
is: CHEBI:57332
boundary condition: false
type: Species
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
constant: false
has only substance units: false
initial amount: NaN
name: crotonoyl-CoA(4-)
initial concentration: 1.0

metaR r1630
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110027#
type: Reaction

metaR r0386
is described by: ECO:0000000
reactant: MODEL1310110027#
fast: false
type: Reaction
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110027#
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
name: 4-methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4

http://identifiers.org/biomodels.db/MODEL1310110027#_b058ef8b_2442_4b06_97be_e1e8a5b25fc8
boundary condition: true
is encoded by: hsa:146712
initial amount: NaN
type: Species
name: B3GNTL1
is: SBO:0000252
is: Q67FW5
has only substance units: false
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_21b44dc2_a84d_4a26_9115_8f028aa575ac
name: _AI656480_1_m
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:AI656480
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species

metaR NDP7g
is: SBO:0000176
product: MODEL1310110027#
reversible: false
modifier: MODEL1310110027#
name: nucleoside-diphosphatase (UDP), Golgi apparatus
is described by: ECO:0000269
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.6.1.6
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#

metaR r2387
product: MODEL1310110027#
modifier: MODEL1310110027#
reversible: false
type: Reaction
kinetic law: MODEL1310110027#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
reactant: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110027#_ca9c50c2_4a28_426d_8014_259319672356
constant: false
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:6470
initial concentration: NaN
has only substance units: false
name: SHMT1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110027#_9b92fc0e_7835_4488_9afc_0cb9770a8b27
boundary condition: true
is: B7Z4Y6
constant: false
has only substance units: false
is encoded by: hsa:249
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
name: ALPL

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

metaR DM dgpi prot hs r
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dgpi prot hs(r)
type: Reaction

metaR S6T6g
is: SBO:0000176
product: MODEL1310110027#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
modifier: MODEL1310110027#
fast: false
reversible: false
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
type: Reaction
is described by: ECO:0000000

metaM cdp c
is: CHEBI:58069
name: CDP
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: HMDB01546
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: C00112
boundary condition: false
type: Species

metaR DUMPtn
fast: false
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110027#
name: dUMP nuclear transport
product: MODEL1310110027#
is: SBO:0000185

metaR AMETt2m
is described by: ECO:0000269
modifier: MODEL1310110027#
is: SBO:0000185
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (115286.3) or (115286.2) or (115286.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14674884 NOTES:Added by RS/TV (6/17/05)
reactant: MODEL1310110027#
type: Reaction
fast: false
product: MODEL1310110027#
reversible: true
name: S-Adenosyl-L-methionine reversible transport, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110027#_e1c6ce98_a1cc_4e47_90d3_78463327bcbb
constant: false
has only substance units: false
boundary condition: true
name: SLC26A8
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:116369
initial amount: NaN

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

metaM m4mpdol L r
type: Species
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C1540H2528N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
is: CHEBI:37633
initial concentration: 1.0
constant: false
boundary condition: false

metaR r1766
is: SBO:0000185
product: MODEL1310110027#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110027#
reversible: false
reactant: MODEL1310110027#
fast: false
modifier: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_7a0e8853_ce58_4d7c_94b5_d6aaae3c72d7
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: _AV727634_1_c
is: SBO:0000252
constant: false
is encoded by: hsa:AV727634
type: Species
boundary condition: true

metaM gacpail hs r
initial amount: NaN
is: SBO:0000247
is: CHEBI:61548
name: glucosaminyl-acylphosphatidylinositol
is: HMDB01401
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: C00092
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0

metaR r2386
is: SBO:0000185
type: Reaction
product: MODEL1310110027#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110027#
modifier: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false
kinetic law: MODEL1310110027#

metaR 3MOPte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of 3-methyl-2-oxopentanoate
reactant: MODEL1310110027#
type: Reaction
reversible: true
is described by: ECO:0000134
is: SBO:0000185
fast: false
product: MODEL1310110027#
kinetic law: MODEL1310110027#

metaR DOLPGT2 Ler
modifier: MODEL1310110027#
is: SBO:0000176
notes: GENE_ASSOCIATION: (79053.1) or (79053.3) or (79053.2) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (liver)
product: MODEL1310110027#
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.265

metaM ocdcea c
is: C00712
name: octadecenoate (n-C18:1)
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:0
notes: FORMULA: C18H33O2 CHARGE: -1
is: HMDB00207
initial amount: NaN

metaR r0021
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
reversible: true
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
is version of: http://identifiers.org/ec-code/3.6.1.5
reactant: MODEL1310110027#
product: MODEL1310110027#
modifier: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110027#_6d984078_c240_4037_a4dd_e1ebd362e79f
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:2746
name: GLUD1
constant: false
boundary condition: true
is: E9KL48
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_13c17a04_e5ea_4161_a3a1_f03084f4dfda
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
constant: false
is encoded by: hsa:341947
initial concentration: NaN
name: COX8C
boundary condition: true
is: Q7Z4L0

metaM ca2 e
boundary condition: false
initial concentration: 1.0
is: CHEBI:29108
name: calcium(2+)
constant: false
is: SBO:0000247
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
type: Species
initial amount: NaN
has only substance units: false
is: HMDB00464

metaR 4HGLSDm
reversible: true
fast: false
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.5.1.12
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
type: Reaction
is described by: ECO:0000212
product: MODEL1310110027#
name: L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
is: SBO:0000176

metaR ATPtm
reactant: MODEL1310110027#
reversible: false
is described by: ECO:0000269
name: ADP/ATP transporter, mitochondrial
is: SBO:0000185
notes: GENE_ASSOCIATION: (291.1) or (293.1) or (292.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
kinetic law: MODEL1310110027#
product: MODEL1310110027#
type: Reaction
fast: false
modifier: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_e408ebe8_17ef_49f5_9b85_f97132e74be6
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
name: CHAT
constant: false
is: P28329
is encoded by: hsa:1103
initial concentration: NaN
initial amount: NaN

metaR r1726
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
is described by: ECO:0000000
modifier: MODEL1310110027#
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
product: MODEL1310110027#
name: Y+LAT2 Utilized transport

metaR HACD1m
reactant: MODEL1310110027#
is described by: ECO:0000134
product: MODEL1310110027#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110027#
fast: false
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
reversible: true
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110027#
type: Reaction

metaM na1 e
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: Na CHARGE: 1
is: HMDB00588
name: Sodium
is: C01330
constant: false
is: CHEBI:4541
type: Species
is: SBO:0000247

metaM dopasf e
is: CHEBI:37946
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB06275
constant: false
name: dopamine 3-O-sulfate
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690

metaR FRDPtr
fast: false
name: lipid, flip-flop intracellular transport
product: MODEL1310110027#
is described by: ECO:0000000
kinetic law: MODEL1310110027#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
reversible: true
reactant: MODEL1310110027#

metaM Ser Thr l
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
name: protein-linked serine or threonine residue (O-glycosylation site)
initial amount: NaN
is: HMDB00224
type: Species
notes: FORMULA: XH CHARGE: 0
is: CHEBI:58190
initial concentration: 1.0

metaM coa r
name: Coenzyme A
has only substance units: false
constant: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:57287
is: C00010
is: SBO:0000247
is: HMDB01423

http://identifiers.org/biomodels.db/MODEL1310110027#_b1a3f72f_8e85_4a5f_8618_e94c369ebf42
initial amount: NaN
is encoded by: hsa:1593
name: CYP27A1
boundary condition: true
is: SBO:0000252
type: Species
is: Q02318
constant: false
initial concentration: NaN
has only substance units: false

metaR SIAASE3ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.2.1.18
name: sialidase, lysosomal
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
reversible: false
type: Reaction
modifier: MODEL1310110027#
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110027#

metaR CERT2rt
product: MODEL1310110027#
type: Reaction
fast: false
is: SBO:0000185
name: ceramide transport protein
reversible: true
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.11.1
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside

metaR r2358
fast: false
reactant: MODEL1310110027#
reversible: true
kinetic law: MODEL1310110027#
type: Reaction
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

metaR G12MT2 L
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110027#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110027#
product: MODEL1310110027#
name: Glycolipid 1,2-alpha-D-mannosyltransferase (liver)
is described by: ECO:0000000

metaR EX 3mop LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxopentanoate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_4473a51a_dd91_4a48_9959_4fd5764923f7
type: Species
is encoded by: hsa:4830
initial concentration: NaN
is encoded by: hsa:4831
has part: P22392
is: SBO:0000297
initial amount: NaN
name: NME1:NME2
has part: P15531
has only substance units: false
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_832c3242_c604_496b_9398_3bea77d25155
boundary condition: true
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
is: Q99884
is encoded by: hsa:6534
has only substance units: false
name: SLC6A7
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_634031ec_12b9_40ff_b36a_a2147b47bedb
is encoded by: hsa:4701
is: Q6FG42
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
name: NDUFA7

metaM dca r
has only substance units: false
constant: false
initial amount: NaN
is: HMDB00705
boundary condition: false
name: Decanoate (n-C10:0)
type: Species
is: SBO:0000247
notes: FORMULA: C10H19O2 CHARGE: -1
initial concentration: 1.0

metaR PHACCOAGLNAC
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
is described by: ECO:0000000
name: Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
reversible: false
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 2.3.1.14 Confidence Level: 2 AUTHORS: NOTES:SAB
product: MODEL1310110027#

metaR SERALANaEx
reactant: MODEL1310110027#
is: SBO:0000185
kinetic law: MODEL1310110027#
product: MODEL1310110027#
fast: false
is described by: ECO:0000269
name: L-alanine/L-serine Na-dependent exchange (Ser-L in)
reversible: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110027#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_14d96902_811e_4825_8e7b_39c838fd4011
is: SBO:0000252
name: GLB1
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:2720
has only substance units: false
is: P16278

http://identifiers.org/biomodels.db/MODEL1310110027#_27e49b3c_a0dd_4f75_8a65_c4e673bba946
is encoded by: hsa:4705
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
is: O95299
has only substance units: false
name: NDUFA10
boundary condition: true

metaR PROt4 2 r
is: SBO:0000185
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reactant: MODEL1310110027#
is described by: ECO:0000006
kinetic law: MODEL1310110027#
name: Proline transport (sodium symport) (2:1)
reversible: true
modifier: MODEL1310110027#
fast: false
type: Reaction

metaM paf hs c
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:36707
boundary condition: false
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
initial concentration: 1.0
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
is: SBO:0000247
type: Species

metaM Lfmkynr c
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB01200
notes: FORMULA: C11H12N2O4 CHARGE: 0 INCHI: InChI=1S/C11H12N2O4/c12-8(11(16)17)5-10(15)7-3-1-2-4-9(7)13-6-14/h1-4,6,8H,5,12H2,(H,13,14)(H,16,17)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00985 EHMN_ABBREVIATION: C02700
name: N-formyl-L-kynurenine
initial concentration: 1.0
initial amount: NaN
is: CHEBI:30249
boundary condition: false
constant: false

metaR LYSOXp
product: MODEL1310110027#
type: Reaction
name: L-lysine oxidase, peroxisomal
is described by: ECO:0000000
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.4.3.14 Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957,PMID:6811962 NOTES:MM
reversible: false
is: SBO:0000176
fast: false
reactant: MODEL1310110027#

metaR r2359
reversible: true
kinetic law: MODEL1310110027#
name: Organic anion transporter 5 Utilized transport
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reactant: MODEL1310110027#

metaR TALA
name: transaldolase
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
fast: false
product: MODEL1310110027#
modifier: MODEL1310110027#
type: Reaction
is version of: http://identifiers.org/ec-code/2.2.1.2
reactant: MODEL1310110027#
is described by: ECO:0000000
kinetic law: MODEL1310110027#
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110027#_c5499692_8128_4a24_ae17_aa4fba1d6bd0
has only substance units: false
boundary condition: true
name: _U52111_1_c
constant: false
is encoded by: hsa:U52111
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

metaR VALt5m
product: MODEL1310110027#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
fast: false
kinetic law: MODEL1310110027#
is described by: ECO:0000000
is: SBO:0000185
name: Valine reversible mitochondrial transport
reactant: MODEL1310110027#

metaR EX txa2 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thromboxane A2 exchange
type: Reaction

metaR THRASNNaEx
is described by: ECO:0000269
kinetic law: MODEL1310110027#
product: MODEL1310110027#
is: SBO:0000185
reversible: false
name: L-threonine/L-asparagine Na-dependent exchange (Thr-L in)
type: Reaction
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
modifier: MODEL1310110027#

metaM xol7aone m
type: Species
has only substance units: false
name: 7alpha-hydroxycholest-4-en-3-one
constant: false
boundary condition: false
initial amount: NaN
is: HMDB01993
initial concentration: 1.0
is: CHEBI:17899
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_d1876bce_cce6_4f2e_8c94_d0bc83dc76b7
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:29926
constant: false
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
name: GMPPA
is: Q96IJ6

http://identifiers.org/biomodels.db/MODEL1310110027#_a7de54d1_28f6_44fd_8bc1_b49fee0fcdac
boundary condition: true
is encoded by: hsa:9058
is: E7ETH5
initial concentration: NaN
constant: false
name: SLC13A2
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_f6c2612a_8747_4f28_9b29_504a6acb5eba
boundary condition: true
name: SLC35C1
is: B3KQH0
is encoded by: hsa:55343
type: Species
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR DGAT
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.20
reactant: MODEL1310110027#
product: MODEL1310110027#
type: Reaction
name: diacylglycerol acyltransferase
reversible: false
notes: GENE_ASSOCIATION: (8694.1) or (84649.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11481335 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
is described by: ECO:0000000

metaM c6dc x
is: HMDB04047
name: adipoyl carnitine
constant: false
notes: FORMULA: C13H22NO6 CHARGE: -1
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: C14143
type: Species
initial amount: NaN
has only substance units: false

metaR RE1254C
is: SBO:0000176
fast: false
reversible: true
kinetic law: MODEL1310110027#
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
name: RE1254
is described by: ECO:0000000
reactant: MODEL1310110027#
type: Reaction

metaR HDCAtr
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110027#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110027#
fast: false
name: fatty acid transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110027#_c8fbb258_3e8e_4ba0_9ce2_08b5440ebac5
type: Species
has only substance units: false
name: RHAG
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q96E98
initial concentration: NaN
is encoded by: hsa:6005

metaR CYTK5n
is: SBO:0000176
product: MODEL1310110027#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110027#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
kinetic law: MODEL1310110027#
fast: false
name: cytidylate kinase (CMP),nuclear
reactant: MODEL1310110027#

metaM na1 c
is: HMDB00588
is: C01330
initial concentration: 1.0
constant: false
notes: FORMULA: Na CHARGE: 1
type: Species
name: Sodium
initial amount: NaN
has only substance units: false
is: CHEBI:4541
boundary condition: false
is: SBO:0000247

metaR ILEPHELAT2tc
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Isoleucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_af0dc5ba_9372_4f64_8061_f1de3c7ced8b
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:4831
name: NME2
boundary condition: true
constant: false
is: P22392

metaR FAOXC141C121m
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:1-->C12:1)m
type: Reaction

metaR ACALDt
type: Reaction
reactant: MODEL1310110027#
name: acetaldehyde reversible transport
kinetic law: MODEL1310110027#
fast: false
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110027#_a469007d_e0f4_490f_9811_239c48ecc952
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:29922
constant: false
name: NME7

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaM cyan c
name: hydrogen cyanide
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB02084
is: SBO:0000247
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
is: CHEBI:18407

metaR CHOLATEt
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
name: cholate transport via bicarbonate countertransport
product: MODEL1310110027#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110027#
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
fast: false

metaM dolmanp L c
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
type: Species
is: CHEBI:15809
constant: false
name: Dolichyl phosphate D-mannose, human liver homolog
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_0444af26_a4ce_43fe_81da_7c227c66ac52
type: Species
is: Q8N0W3
name: FUK
is encoded by: hsa:197258
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR GGH 7THFe
product: MODEL1310110027#
modifier: MODEL1310110027#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.4.19.9
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110027#
name: Gamma-glutamyl hydrolase (7THF), extracellular
reversible: false
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT

http://identifiers.org/biomodels.db/MODEL1310110027#_58b07830_f174_409a_8a1d_66069eb3fdab
type: Species
name: _AI024818_1_c
initial amount: NaN
is encoded by: hsa:AI024818
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false

metaM dd2coa m
boundary condition: false
is: SBO:0000247
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
initial concentration: 1.0
is: HMDB03712
initial amount: NaN
constant: false
is: CHEBI:57330
type: Species
name: trans-dodec-2-enoyl-CoA(4-)
has only substance units: false

metaM dadp c
is: CHEBI:57667
constant: false
is: SBO:0000247
is: C00206
is: HMDB01508
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
boundary condition: false
name: dADP
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_a43a31cd_59db_497b_af4f_de808f2d23ad
constant: false
type: Species
is encoded by: hsa:4846
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
name: NOS3
is: A0S0A7

metaR FAOXC123C102m
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:3-->C10:2)m
type: Reaction

metaM c4dc x
notes: FORMULA: C11H18NO6 CHARGE: -1
is: HMDB02013
is: C02862
name: succinyl carnitine
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/213144

metaR DM atp c
type: Reaction
is: SBO:0000176
name: DM_atp(c)
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reversible: false
is described by: ECO:0000134
fast: false
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:

metaM itacon m
is: HMDB02092
constant: false
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
boundary condition: false
initial concentration: 1.0
is: CHEBI:17240
type: Species
name: itaconate(2-)
is: SBO:0000247
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_5bcd8d10_be10_45ed_9673_f8dc0e427f22
constant: false
is: Q53Y25
has only substance units: false
name: GCK
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:2645

http://identifiers.org/biomodels.db/MODEL1310110027#_cc26f056_645b_4c40_86f5_fe0481623baa
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:4707
is: O75438
name: NDUFB1
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_de55d48f_fc03_4568_bbbe_c2a0ff10aafe
name: ADSSL1
type: Species
is: B3KTV4
is: SBO:0000252
is encoded by: hsa:122622
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_f6f0f5a7_b4dc_499e_b0f8_2ace9860b69c
name: PANK3
type: Species
is: Q9H999
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:79646

metaM paf hs e
boundary condition: false
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:36707
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0

metaR r0570
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
is: SBO:0000176
kinetic law: MODEL1310110027#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.3.2
reactant: MODEL1310110027#
product: MODEL1310110027#
modifier: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_50712a63_8744_45b1_86e5_f3e7bc441076
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
name: _AI090874_1_c
is encoded by: hsa:AI090874

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

metaM gd3 hs g
has only substance units: false
constant: false
initial concentration: 1.0
name: GD3
is: CHEBI:28424
notes: FORMULA: C52H88N3O28FULLRCO CHARGE: -2
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_c5817eb1_cc69_4e61_a8b8_4bd97f8db614
initial amount: NaN
constant: false
initial concentration: NaN
is: Q13370
name: PDE3B
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5140
has only substance units: false
type: Species

metaR r0917
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: true
kinetic law: MODEL1310110027#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110027#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110027#_6e052e74_991c_4234_8054_214745c9ff97
initial amount: NaN
constant: false
is encoded by: hsa:4723
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is: E5KNH5
name: NDUFV1

metaR RE0935E
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.2.1.17
is: SBO:0000176
modifier: MODEL1310110027#
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.2.1.1
fast: false
product: MODEL1310110027#
name: RE0935
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:

metaM tsul e
type: Species
is: HMDB00257
name: thiosulfate(2-)
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
boundary condition: false
initial concentration: 1.0
is: CHEBI:16094
initial amount: NaN

metaM maltpt e
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
is: SBO:0000247
type: Species
initial amount: NaN
name: maltopentaose
has only substance units: false
initial concentration: 1.0
is: C02052
is: HMDB01296
is: http://identifiers.org/pubchem.compound/5141
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110027#_41884d4a_8c15_4425_a6fe_204e8700d25b
name: PPT1
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:5538
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is: Q6FGQ4

metaM coa n
initial concentration: 1.0
name: coenzyme A(4-)
is: HMDB01423
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:57287
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
initial amount: NaN
constant: false

metaR DAG HSter
type: Reaction
kinetic law: MODEL1310110027#
is: SBO:0000185
product: MODEL1310110027#
fast: false
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:
name: diacylglycerol ER export
reversible: false
is described by: ECO:0000000

metaM ppi x
boundary condition: false
is: C00013
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB00250
name: Diphosphate
is: CHEBI:33019
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
has only substance units: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_9837baf4_c4f4_4b73_88f3_dc44cb4d977b
name: _AI091231_1_c
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:AI091231
boundary condition: true
initial concentration: NaN

metaM dcmp c
is: HMDB01202
is: C00239
name: dCMP
has only substance units: false
is: CHEBI:57566
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239

metaM cyan e
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
name: hydrogen cyanide
initial amount: NaN
boundary condition: false
constant: false
is: HMDB02084
has only substance units: false
is: CHEBI:18407
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR r0013
product: MODEL1310110027#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.2.1.52 Confidence Level: 0 AUTHORS: PMID:10481922,PMID:2423070,PMID:6219664,PMID:758959 NOTES:
kinetic law: MODEL1310110027#
name: beta-N-acetylhexosaminidase Aminosugars metabolism EC:3.2.1.52
type: Reaction
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110027#
is described by: ECO:0000000
reversible: false

metaR r0797
type: Reaction
product: MODEL1310110027#
name: glycine N-choloyltransferase EC:2.3.1.65
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
reactant: MODEL1310110027#
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
is: SBO:0000176
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:

metaM citr L m
is: CHEBI:16349
constant: false
initial amount: NaN
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB00904
name: L-citrulline
type: Species

metaR GGH 6THFe
name: Gamma-glutamyl hydrolase (6THF), extracellular
type: Reaction
reversible: false
reactant: MODEL1310110027#
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.4.19.9
is: SBO:0000176
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
kinetic law: MODEL1310110027#
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_6ebb91b7_4edd_433f_8912_857921f77c21
constant: false
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
name: PKLR
is: P30613
boundary condition: true
is encoded by: hsa:5313

metaR COAtp
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110027#
type: Reaction
name: coenzyme A transport, peroxisomal
is: SBO:0000185
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110027#
fast: false

metaM coa m
is: HMDB01423
initial amount: NaN
boundary condition: false
constant: false
name: Coenzyme A
is: CHEBI:57287
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: C00010

http://identifiers.org/biomodels.db/MODEL1310110027#_d8b01415_4340_49df_ab6f_942614667c49
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:51268
constant: false
initial amount: NaN
name: PIPOX
type: Species
initial concentration: NaN
is: Q9P0Z9

http://identifiers.org/biomodels.db/MODEL1310110027#_c24f64e7_a482_4f76_90c9_2165fc7f555b
constant: false
initial concentration: NaN
is: P11908
boundary condition: true
name: PRPS2
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:5634
is: SBO:0000252

metaR CORE2GTg
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.4.1.102
reactant: MODEL1310110027#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (9245.1) or (2650.1) or (51301.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:10753916,PMID:9915862 NOTES:NCD
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
is described by: ECO:0000000

metaR ARGtm
fast: false
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is described by: ECO:0000269
type: Reaction
name: arginine mitochondrial transport via ornithine carrier
reactant: MODEL1310110027#
reversible: true
is: SBO:0000185
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_4be0ab6c_16cc_406c_85c2_6214a26ffd16
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: Q86U05
type: Species
name: SLC7A8
initial amount: NaN
is encoded by: hsa:23428
constant: false

metaM idp e
is: CHEBI:58280
has only substance units: false
initial amount: NaN
name: IDP(3-)
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB03335
type: Species
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104

metaR r0796
modifier: MODEL1310110027#
type: Reaction
product: MODEL1310110027#
fast: false
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:

metaM dtmp c
is: HMDB01227
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:26999
name: dTMP
is: SBO:0000247
is: C00364
initial amount: NaN
constant: false
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110027#_26115c56_2681_4066_8085_b71619cc4a68
initial amount: NaN
name: HADHB
type: Species
is: P55084
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3032

http://identifiers.org/biomodels.db/MODEL1310110027#_713fb9fb_0318_4f73_ad6b_cd7659b986cd
type: Species
name: GALNT13
constant: false
initial concentration: NaN
is: Q8IUC8
initial amount: NaN
is encoded by: hsa:114805
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR EX 2mcit LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Methylcitrate exchange
type: Reaction

metaR HDCEAtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
name: fatty acid transport via diffusion
is: SBO:0000185
fast: false
product: MODEL1310110027#
reversible: true
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
type: Reaction

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

metaR COAtm
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
reactant: MODEL1310110027#
is: SBO:0000185
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
type: Reaction
fast: false
reversible: true
is described by: ECO:0000269
name: CoA transporter

http://identifiers.org/biomodels.db/MODEL1310110027#_e6d38499_b21c_4b67_8dd6_521471fa0aff
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:728226
name: _728226_1_e
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_9700de9a_f932_468c_86d2_9cc103340276
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:3613
initial concentration: NaN
is: O14732
name: IMPA2
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_70c2355a_fdcb_4945_93d7_0795225c4e9c
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
name: IDH3B
is encoded by: hsa:3420

metaM dopasf c
is: SBO:0000247
is: CHEBI:37946
type: Species
initial amount: NaN
boundary condition: false
is: HMDB06275
initial concentration: 1.0
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
constant: false
has only substance units: false
name: dopamine 3-O-sulfate

http://identifiers.org/biomodels.db/MODEL1310110027#_efbb9f69_7fc2_42da_be80_bb90aca4c2c9
is: E7EPT3
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: ALDH7A1
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:501

metaM acac m
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
name: acetoacetate
is: CHEBI:13705
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: HMDB00060
constant: false
initial amount: NaN

metaR SUCCtp
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110027#
is: SBO:0000185
kinetic law: MODEL1310110027#
name: succinate transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
type: Reaction
product: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_c9c059d8_03de_4e7c_81b9_9587e8615516
is: E9KL44
constant: false
name: HADHA
boundary condition: true
is encoded by: hsa:3030
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species

metaM tsul c
is: SBO:0000247
initial amount: NaN
is: HMDB00257
initial concentration: 1.0
name: thiosulfate(2-)
has only substance units: false
type: Species
is: CHEBI:16094
boundary condition: false
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_12aaa282_dff3_4e49_af27_38ccf50c68f5
constant: false
name: PIGG
is encoded by: hsa:54872
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: Q8NCI4
type: Species
initial concentration: NaN

metaR r0127
modifier: MODEL1310110027#
name: L-Asparagine amidohydrolase Alanine and aspartate metabolism / Cyanoamino acid metabolism / Nitrogen metabolism EC:3.5.1.1 EC:3.5.1.38
is: SBO:0000176
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.5.4.16
reactant: MODEL1310110027#
type: Reaction
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.38 Confidence Level: 0 AUTHORS: PMID:4311065,PMID:4894450 NOTES:
is described by: ECO:0000000
product: MODEL1310110027#
reversible: false
fast: false

metaR r0575
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.48
kinetic law: MODEL1310110027#
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
type: Reaction
fast: false
reactant: MODEL1310110027#
product: MODEL1310110027#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
modifier: MODEL1310110027#
is described by: ECO:0000000

metaM Asn X Ser Thr r
initial amount: NaN
is: SBO:0000247
is: CHEBI:28938
name: protein-linked asparagine residue (N-glycosylation site)
constant: false
initial concentration: 1.0
is: C01342
is: HMDB00051
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: XH CHARGE: 0

metaR BILIRED
is described by: ECO:0000000
name: Nad(p)h biliverdin reductase
is version of: http://identifiers.org/ec-code/1.3.1.24
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (645.1) or (644.1) SUBSYSTEM: Heme degradation EC Number: 1.3.1.24 Confidence Level: 0 AUTHORS: PMID:12456881,PMID:7656592,PMID:8117274 NOTES:TDV
is: SBO:0000176
fast: false
product: MODEL1310110027#
reversible: false

metaR 6HTSTSTERONEtr
product: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, inactivated testosterone transport to get out of cell NJ
reversible: true
is: SBO:0000185
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
is described by: ECO:0000000
type: Reaction
name: hydroxylated testosterone transport

metaR FALDH
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.1.1.1
is: SBO:0000176
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
reactant: MODEL1310110027#
name: formaldehyde dehydrogenase
reversible: true
type: Reaction
product: MODEL1310110027#

metaM g3pc c
is: SBO:0000247
name: sn-Glycero-3-phosphocholine
is: HMDB00086
is: CHEBI:16870
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C8H20NO6P CHARGE: 0 INCHI: InChI=1S/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/p+1/t8-/m1/s1 EHMN_ABBREVIATION: C00670
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_8b6aff44_84f9_4b6a_91db_cff788c03475
is encoded by: hsa:56953
has only substance units: false
name: NT5M
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
boundary condition: true
is: Q9NPB1

metaM lnlncg c
type: Species
name: gamma-linolenate
is: SBO:0000247
is: HMDB03073
is: CHEBI:32391
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-

http://identifiers.org/biomodels.db/MODEL1310110027#_02b69e2b_9822_4236_97e0_b3ac435235c6
constant: false
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:4967
initial amount: NaN
is: SBO:0000252
is: Q02218
name: OGDH
initial concentration: NaN

metaM xol7aone r
constant: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
initial concentration: 1.0
name: 7alpha-hydroxycholest-4-en-3-one
boundary condition: false
is: HMDB01993
initial amount: NaN
is: CHEBI:17899
has only substance units: false
type: Species
is: SBO:0000247

metaR PHEt4
reactant: MODEL1310110027#
is: SBO:0000185
reversible: false
type: Reaction
is described by: ECO:0000269
product: MODEL1310110027#
fast: false
name: L-phenylalanine transport in via sodium symport
notes: GENE_ASSOCIATION: (54407.1) or (84889.1) or (11254.1) or (6542.1) or (81539.1) or (6541.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#

metaR EX thym LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymine exchange
type: Reaction

metaM prpncoa m
name: acryloyl-CoA(4-)
is: HMDB02307
boundary condition: false
is: SBO:0000247
is: CHEBI:57367
has only substance units: false
initial amount: NaN
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
type: Species
initial concentration: 1.0
constant: false

metaR EX HC02203 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-a2 exchange
type: Reaction

metaR COAtn
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
name: coenzyme A transport, nuclear
reversible: true
is: SBO:0000185
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110027#_d6418cc8_886a_4980_950c_7e3ecb714601
name: SLC6A9
is encoded by: hsa:6536
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: P48067
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaM ksii core4 deg1 l
is: HMDB00868
initial amount: NaN
initial concentration: 1.0
name: keratan sulfate II (core 4-linked), degradation product 1
is: CHEBI:57737
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C78H126N6O64S3X CHARGE: -3
type: Species
constant: false

metaR PRASCS
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
fast: false
name: phosphoribosylaminoimidazolesuccinocarboxamide synthase
product: MODEL1310110027#
reactant: MODEL1310110027#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.2.6
type: Reaction
is described by: ECO:0000269

metaR r1725
is described by: ECO:0000000
product: MODEL1310110027#
reactant: MODEL1310110027#
reversible: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110027#
name: Y+LAT2 Utilized transport
type: Reaction
is: SBO:0000185
fast: false
modifier: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_6e3ca7cc_51a3_4acd_84b7_308373169aa8
is: Q5JWV8
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:2182
type: Species
name: ACSL4
initial concentration: NaN
has only substance units: false

metaR ALAtN1
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
product: MODEL1310110027#
reversible: true
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
reactant: MODEL1310110027#
type: Reaction
is: SBO:0000185
name: Alanine transport (Na, H coupled)
fast: false

metaM 2mbcoa m
is: CHEBI:57336
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
type: Species
initial concentration: 1.0
is: HMDB01041
name: 2-methylbutanoyl-CoA(4-)
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaR TRPO2
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (6999.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.13.11.11 Confidence Level: 4 AUTHORS: PMID:8666386 NOTES:NCD
fast: false
is described by: ECO:0000269
name: L-Tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
product: MODEL1310110027#
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.13.11.11
modifier: MODEL1310110027#
type: Reaction
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110027#_c1eb8186_c680_4c70_9562_9162dfb8db0b
is: SBO:0000252
boundary condition: true
is: Q8IWX5
has only substance units: false
initial concentration: NaN
name: SGPP2
is encoded by: hsa:130367
constant: false
type: Species
initial amount: NaN

metaR RE2999M
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
name: RE2999
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
product: MODEL1310110027#
type: Reaction
reversible: true
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/5.3.3.8
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is described by: ECO:0000000

metaM dcholcoa r
boundary condition: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28701
initial amount: NaN
type: Species
has only substance units: false
name: chenodeoxycholoyl coenzyme a
is: HMDB06292

metaR PSt3
is: SBO:0000185
type: Reaction
reversible: true
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
fast: false
name: phosphatidylserine transport
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110027#_26363864_2a92_4ca7_850a_8bb337c09388
is: Q8N5Z0
name: AADAT
initial amount: NaN
is encoded by: hsa:51166
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_9a936285_1926_475d_99df_c3fcd86e97de
is encoded by: hsa:115111
has only substance units: false
name: SLC26A7
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q8TE54
initial amount: NaN
boundary condition: true

metaM dolp L r
has only substance units: false
name: dolichyl phosphate(2-)
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
is: CHEBI:57683
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_6d8262b1_8b29_4d02_aab7_2832d51716ea
is encoded by: hsa:1329
has part: Q02221
initial concentration: NaN
is encoded by: hsa:1351
constant: false
is encoded by: hsa:1346
has part: Q53XN1
has part: Q7Z4L0
has part: H0UI06
boundary condition: true
has part: Q6YFQ2
is encoded by: hsa:4513
is encoded by: hsa:9167
is encoded by: hsa:1350
is encoded by: hsa:1340
has part: Q8TF08
has part: P13073
is: SBO:0000297
is encoded by: hsa:1345
is encoded by: hsa:1347
is encoded by: hsa:1337
is encoded by: hsa:1327
is encoded by: hsa:9377
is encoded by: hsa:4512
has only substance units: false
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
has part: Q7GXZ8
has part: Q6FGA0
has part: P20674
has part: Q7GXY8
has part: P15954
has part: P24310
has part: P14854
has part: P24311
has part: P00414
type: Species
has part: P12074
is encoded by: hsa:170712
has part: Q53YB7
has part: Q96KJ9
is encoded by: hsa:1349
is encoded by: hsa:1339
is encoded by: hsa:341947
is encoded by: hsa:4514
has part: P09669
is encoded by: hsa:84701
initial amount: NaN
is encoded by: hsa:125965

http://identifiers.org/biomodels.db/MODEL1310110027#_99993618_394e_4954_8711_d8c2771bb52b
boundary condition: true
constant: false
name: HADHA
is: SBO:0000252
has only substance units: false
is: E9KL44
type: Species
is encoded by: hsa:3030
initial amount: NaN
initial concentration: NaN

metaR AG13T13g
product: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110027#
is: SBO:0000176

metaM malthp e
constant: false
is: C01936
boundary condition: false
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
name: maltoheptaose
is: http://identifiers.org/pubchem.compound/5041
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaM retn r
is: SBO:0000247
is: CHEBI:35291
name: all-trans-retinoate
boundary condition: false
has only substance units: false
is: HMDB01852
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species

metaM dtmp e
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:26999
initial amount: NaN
constant: false
name: dTMP(2-)
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
is: HMDB01227
initial concentration: 1.0

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_dade09c1_06ed_4bb9_9bf0_cc53adbc060a
is encoded by: hsa:1375
has only substance units: false
is: SBO:0000252
constant: false
is: Q53FV7
type: Species
initial amount: NaN
name: CPT1B
initial concentration: NaN
boundary condition: true

metaM acac x
is: HMDB00060
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
boundary condition: false
is: CHEBI:13705
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
name: acetoacetate
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_5ac9da97_3e28_4c65_a978_157ab118392b
type: Species
is: O60312
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
name: ATP10A
boundary condition: true
is encoded by: hsa:57194

metaM atp c
is: CHEBI:30616
has only substance units: false
name: ATP(4-)
type: Species
initial concentration: 1.0
initial amount: NaN
is: C00002
constant: false
is: HMDB00538
is: SBO:0000247
boundary condition: false

metaM s2l2n2m2mn l
constant: false
initial amount: NaN
name: de-Fuc, reducing GlcNAc removed form of PA6 (w/o peptide linkage)
is: HMDB01356
notes: FORMULA: C76H123N5O57 CHARGE: -2
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:57312

metaM ascb L c
type: Species
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
is: SBO:0000247
is: CHEBI:38290
is: HMDB00044
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: L-ascorbate
constant: false
has only substance units: false

metaM gdpmann c
type: Species
is: CHEBI:57527
is: HMDB01163
name: GDP-alpha-D-mannose(2-)
is: SBO:0000247
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN

metaR r1585
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110027#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110027#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110027#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110027#_7a4511cb_5639_4408_951d_b58f8552083c
type: Species
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: B3GNT2
is encoded by: hsa:10678

http://identifiers.org/biomodels.db/MODEL1310110027#_9a1e01b0_4137_48cb_a009_96dfff09773b
constant: false
has only substance units: false
is encoded by: hsa:5143
name: PDE4C
type: Species
is: Q7KYS4
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR r0129
kinetic law: MODEL1310110027#
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
product: MODEL1310110027#
reactant: MODEL1310110027#
is: SBO:0000176
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.40
modifier: MODEL1310110027#
reversible: true
is described by: ECO:0000000

metaM ala L c
name: L-alanine
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB00161
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:16977

metaR r2201
type: Reaction
modifier: MODEL1310110027#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
kinetic law: MODEL1310110027#
is: SBO:0000185
product: MODEL1310110027#
reactant: MODEL1310110027#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5

http://identifiers.org/biomodels.db/MODEL1310110027#_4164cc8c_209f_44c4_9804_c645368f4bfe
is encoded by: hsa:9498
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: E7EML0
constant: false
has only substance units: false
name: SLC4A8

http://identifiers.org/biomodels.db/MODEL1310110027#_fe70de4e_8885_407a_ac54_2cb37585d85f
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
name: BDH1
is encoded by: hsa:622
initial concentration: NaN
is: Q02338
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_6aa062bf_c2f5_4710_86e2_c15962339e5a
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: ACSS2
initial concentration: NaN
boundary condition: true
is: Q5QPH3
is encoded by: hsa:55902

metaM 2obut c
type: Species
boundary condition: false
name: 2-Oxobutanoate
is: SBO:0000247
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
has only substance units: false
is: C00109
constant: false
is: CHEBI:16763
initial concentration: 1.0
is: HMDB00005
initial amount: NaN

metaM dd2coa x
constant: false
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB03712
has only substance units: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
name: trans-Dodec-2-enoyl-CoA
is: CHEBI:57330
is: SBO:0000247

metaM spmd c
is: C00315
name: Spermidine
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB01257
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
type: Species
is: CHEBI:57834
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110027#_226740ee_c3f3_4da8_9b8d_a5548104c4c9
name: CHKA
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:1119
boundary condition: true
has only substance units: false

metaR r1584
is described by: ECO:0000000
kinetic law: MODEL1310110027#
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110027#
product: MODEL1310110027#

metaM glyphe c
is: SBO:0000247
name: Glycylphenylalanine
is: http://identifiers.org/pubchem.compound/97415
constant: false
initial concentration: 1.0
notes: FORMULA: C11H14N2O3 CHARGE: 0
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_7509db5a_4afa_4e1e_879a_a4e45c07b557
boundary condition: true
is: E5KNH5
initial concentration: NaN
is encoded by: hsa:4723
has only substance units: false
constant: false
is: SBO:0000252
type: Species
name: NDUFV1
initial amount: NaN

metaM 2hexdtricoa m
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
constant: false
type: Species
is: HMDB02288
is: SBO:0000247
has only substance units: false
name: 2,7,10-hexadecatrienoylcoa
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaM cmpacna n
type: Species
name: CMP-N-acetyl-beta-neuraminate(2-)
is: CHEBI:57812
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01176
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
constant: false

metaR CYANtm
reactant: MODEL1310110027#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:assumed to be readily diffusible MM
type: Reaction
product: MODEL1310110027#
is described by: ECO:0000000
name: Cyanide transport via diffusion (mitochondrial)
kinetic law: MODEL1310110027#
reversible: true

metaM ksi pre7 g
notes: FORMULA: C115H187N8O85SX CHARGE: -2
type: Species
is: HMDB00175
constant: false
is: CHEBI:58053
has only substance units: false
boundary condition: false
is: C00130
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 7

http://identifiers.org/biomodels.db/MODEL1310110027#_e14bf4ad_8a8c_42ef_82ef_eb86d9741902
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
name: LYZL1
is: Q6UWQ5
constant: false
is encoded by: hsa:84569
has only substance units: false
initial concentration: NaN

metaR DESAT18 10
reactant: MODEL1310110027#
product: MODEL1310110027#
reversible: false
fast: false
type: Reaction
is described by: ECO:0000000
name: fatty acyl-CoA desaturase (n-C18:2CoA -> n-C18:3CoA)
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
is: SBO:0000176
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#

metaR NMNS
reversible: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
product: MODEL1310110027#
fast: false
name: NMN synthetase
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:19513556 NOTES:
is described by: ECO:0000134

metaR CYSTHRNaEx
product: MODEL1310110027#
fast: false
is: SBO:0000185
name: L-cysteine/L-threonine Na-dependent exchange (Cys-L in)
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110027#
type: Reaction
modifier: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaM thym e
is: HMDB00262
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:17821
name: thymine
type: Species
notes: FORMULA: C5H6N2O2 CHARGE: 0 INCHI: InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178

metaR r2202
reactant: MODEL1310110027#
fast: false
modifier: MODEL1310110027#
product: MODEL1310110027#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
kinetic law: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_1726383d_8223_49f1_96e0_b1c9556e8680
name: GCDH
is encoded by: hsa:2639
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
is: Q92947
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_990ced07_e856_4188_b5ed_37f533ef28de
boundary condition: true
initial amount: NaN
name: PLA2G6
has only substance units: false
is: SBO:0000252
is encoded by: hsa:8398
constant: false
is: A8K460
type: Species
initial concentration: NaN

metaR FAOXC103C102m
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_84e393b3_63cf_4994_9633_a88ef2b158bc
name: PLCG1
is: P19174
boundary condition: true
is encoded by: hsa:5335
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_c416c9e9_5e04_4398_8951_65fda94bb6ea
has only substance units: false
name: PLCB4
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:5332
is: Q15147
boundary condition: true
type: Species

metaM xylu L c
is: CHEBI:17399
name: L-xylulose
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB00751
initial amount: NaN
type: Species
constant: false

metaM tetd7ecoa m
is: SBO:0000247
has only substance units: false
type: Species
is: C05280
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
name: 7-tetradecenoylcoa
boundary condition: false
constant: false
is: HMDB03952
initial concentration: 1.0
initial amount: NaN

metaM m7mpdol L r
initial amount: NaN
notes: FORMULA: C1720H2828N20O570P20 CHARGE: -20
is: CHEBI:37636
is: SBO:0000247
type: Species
name: (alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110027#_5ca74097_1ae8_4e12_98e8_4d5f59986ee5
name: _AI539321_1_c
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:AI539321
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110027#_9d110015_5180_456f_83be_fb75a1aa9d66
is: Q96Q11
name: TRNT1
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:51095
constant: false
boundary condition: true
has only substance units: false
type: Species

metaR AG13T9g
product: MODEL1310110027#
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: (146712.1) or (79369.1) or (10331.1) or (374907.1) or (10678.2) or (374907.2) or (10678.1) or (11041.1) or (93010.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110027#
is: SBO:0000176
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110027#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_af9aef5f_abe4_413f_b1ac_fdf29f60cf27
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:AI915649
name: _AI915649_1_c
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_94b101db_956b_40fd_8299_fe29ed1a66a9
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
name: MTHFD2
is: P13995
is encoded by: hsa:10797
type: Species

metaR NDPK4n
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
is: SBO:0000176
reactant: MODEL1310110027#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
type: Reaction
fast: false
name: nucleoside-diphosphate kinase (ATP:dTDP), nuclear
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
product: MODEL1310110027#

metaR r0236
kinetic law: MODEL1310110027#
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110027#
modifier: MODEL1310110027#
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.5.1.6
is: SBO:0000176
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:

metaM frdp x
is: HMDB00961
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: SBO:0000247
type: Species
is: CHEBI:175763
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: farnesyl pyrophosphate(3-)
constant: false
has only substance units: false

metaR r1587
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110027#
fast: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110027#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110027#
reversible: true

metaR r0579
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
modifier: MODEL1310110027#
type: Reaction
reactant: MODEL1310110027#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110027#
reversible: true
is version of: http://identifiers.org/ec-code/1.13.11.19
is described by: ECO:0000000
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110027#_34a6f298_3451_4a40_9908_e8befdfee882
initial amount: NaN
has only substance units: false
name: RPIA
boundary condition: true
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:22934
initial concentration: NaN
is: P49247

metaR r0791
fast: false
product: MODEL1310110027#
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
modifier: MODEL1310110027#
reactant: MODEL1310110027#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110027#

metaM HC01842 c
has only substance units: false
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
name: Phosphodimethylethanolamine
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:31997
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110027#_3ca772fd_1a49_4ef2_8ca2_4d389753748a
boundary condition: true
type: Species
name: ACHE
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:43
is: SBO:0000252
initial concentration: NaN
is: P22303

metaR r0647
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
product: MODEL1310110027#
name: Spontaneous reaction
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
reversible: true

metaR TYRTA
is described by: ECO:0000269
product: MODEL1310110027#
reactant: MODEL1310110027#
fast: false
type: Reaction
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.1
reversible: true
name: tyrosine transaminase
kinetic law: MODEL1310110027#

metaR C4x
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: esterification of butyrylcoa to butyrylcarnitine for transport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_f5d86d60_3aa1_4d76_879f_c4fa7231ef2c
constant: false
has only substance units: false
type: Species
is: Q53G02
name: DAD1
initial amount: NaN
is encoded by: hsa:1603
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR DNDPt36m
product: MODEL1310110027#
is described by: ECO:0000269
modifier: MODEL1310110027#
fast: false
type: Reaction
reactant: MODEL1310110027#
name: dGDP transport via dCDP antiport
kinetic law: MODEL1310110027#
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

metaR CYSTGLUex
name: L-cystine/L-glutamate exchanger
modifier: MODEL1310110027#
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110027#
fast: false
reactant: MODEL1310110027#
product: MODEL1310110027#
reversible: false
notes: GENE_ASSOCIATION: (23657.1 and 6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310

metaM spmd e
is: SBO:0000247
name: Spermidine
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB01257
type: Species
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
is: CHEBI:57834
is: C00315
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110027#_4726c23a_1be2_4a22_8557_7f6bc6cb4cf9
is: SBO:0000252
constant: false
is encoded by: hsa:160851
is: Q86XP1
name: DGKH
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN

metaR r0434
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
fast: false
is described by: ECO:0000000
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is: SBO:0000176

metaM coa g
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57287
has only substance units: false
name: coenzyme A(4-)
is: HMDB01423
boundary condition: false
constant: false
is: SBO:0000247
type: Species

metaM idp c
initial amount: NaN
name: IDP(3-)
constant: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
is: CHEBI:58280
is: HMDB03335
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR EX nrpphr LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Norepinephrine exchange
type: Reaction

metaR r1586
fast: false
type: Reaction
kinetic law: MODEL1310110027#
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110027#
is described by: ECO:0000000
product: MODEL1310110027#

metaR r0578
kinetic law: MODEL1310110027#
reversible: true
is described by: ECO:0000000
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/4.1.2.27
type: Reaction
reactant: MODEL1310110027#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
modifier: MODEL1310110027#
is: SBO:0000176

metaR RE2349C
modifier: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES:IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C
is version of: http://identifiers.org/ec-code/2.6.1.64
reversible: true
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000000
type: Reaction
name: RE2349
is: SBO:0000176

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

metaR COAtr
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
product: MODEL1310110027#
is: SBO:0000185
reactant: MODEL1310110027#
name: COA transporter, endoplasmic reticulum
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110027#_bdf1c059_6591_4ccb_82d4_8426f8f7e506
type: Species
name: _AU149534_1_c
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:AU149534
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_e8f37a51_f1fd_4270_a6cb_1a5389ceff28
is: SBO:0000252
name: DDOST
constant: false
initial amount: NaN
has only substance units: false
is: P39656
is encoded by: hsa:1650
type: Species
initial concentration: NaN
boundary condition: true

metaR PHCHGSm
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reversible: true
kinetic law: MODEL1310110027#
fast: false
name: L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial
product: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:taken from KEGG map. No enzyme assigned, so assumed this is a non-enzymatic reaction. NCD

http://identifiers.org/biomodels.db/MODEL1310110027#_5ea3acf8_27a8_4d54_8c23_8719fcf11ab6
has only substance units: false
is: Q9BWD1
is encoded by: hsa:39
initial amount: NaN
boundary condition: true
name: ACAT2
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false

metaM 2docopencoa m
constant: false
name: 2,7,10,13,16-docosapentenoylcoa
has only substance units: false
boundary condition: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
type: Species
is: HMDB02288
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaM Ser Thr g
name: protein-linked serine or threonine residue (O-glycosylation site)
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: XH CHARGE: 0
initial amount: NaN
is: HMDB00143
is: CHEBI:0
is: C00124
constant: false

metaM tchola c
type: Species
is: HMDB00036
initial amount: NaN
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
is: CHEBI:36257
is: SBO:0000247
name: taurocholic acid
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false

metaR MALSO4tm
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
modifier: MODEL1310110027#
is described by: ECO:0000269
fast: false
name: Malate:sulfate antiport, mitochondrial
product: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#
reversible: true
reactant: MODEL1310110027#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110027#_37364404_c9fa_4975_9f4c_3c4a5834d6da
initial concentration: NaN
constant: false
is: P04843
has only substance units: false
is encoded by: hsa:6184
initial amount: NaN
type: Species
is: SBO:0000252
name: RPN1
boundary condition: true

metaM pac c
is: CHEBI:18401
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
name: phenylacetate
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
is: HMDB00209
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_791aedc1_7a87_419a_94da_849b8522468e
name: DECR1
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1666
constant: false
is: Q16698

metaR r1589
reactant: MODEL1310110027#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110027#
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110027#
type: Reaction

metaM Asn X Ser Thr l
initial concentration: 1.0
type: Species
notes: FORMULA: XH CHARGE: 0
initial amount: NaN
is: CHEBI:28938
has only substance units: false
is: HMDB00051
name: protein-linked asparagine residue (N-glycosylation site)
boundary condition: false
is: SBO:0000247
constant: false
is: C01342

metaM na1 r
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
has only substance units: false
is: HMDB00588
is: CHEBI:29101
name: sodium(1+)
initial concentration: 1.0
initial amount: NaN
constant: false

metaR P5CDm
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Glutamate metabolism EC Number: 1.5.1.12 Confidence Level: 4 AUTHORS: PMID:8621661,PMID:9700195 NOTES:NCD
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.5.1.12
type: Reaction
reactant: MODEL1310110027#
modifier: MODEL1310110027#
fast: false
reversible: false
is: SBO:0000176
product: MODEL1310110027#
is described by: ECO:0000269
name: 1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

metaM tsul m
name: thiosulfate(2-)
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB00257
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:16094

metaR NACHEX25ly
product: MODEL1310110027#
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
reversible: false
reactant: MODEL1310110027#
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110027#_d0bee058_18f0_4325_a95c_0510abba9b6e
type: Species
name: PRPS1
constant: false
has only substance units: false
is encoded by: hsa:5631
is: P60891
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_e4f7b1d0_5e01_48f1_9c8f_2000a3fa8d4a
initial amount: NaN
is encoded by: hsa:3037
is: Q92819
type: Species
has only substance units: false
name: HAS2
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false

MODEL1310110027#
species: metaM 3ddecdicoa m
stoichiometry: 0.036117
species: metaM HC01231 c
species: metaM peamn c
species: metaM CE4794 m
species: metaM 10fthf5glu e
species: metaM icit c
species: metaM doldp L r
stoichiometry: 0.159671
species: metaM chsterol m
species: metaM oaa m
species: metaM 3mob m
species: metaM dcdp m
species: metaM pail5p hs c
species: metaM HC01162 c
species: metaM creat e
species: metaM hdcoa m
species: metaM gchola x
species: metaM pan4p e
species: metaM atp m
species: metaM o2s m
species: metaM ksi pre9 g
species: metaM chol n
species: metaM accoa n
species: metaM dttp c
species: metaM pheme c
species: metaM paps c
species: metaM pchol hs c
species: metaM ficytC m
species: metaM citr L e
species: metaM mi1345p c
species: metaM oh1 e
stoichiometry: 0.31269
species: metaM ps hs e
species: metaM pyr m
species: metaM o2 x
species: metaM HC02216 c
species: metaM 10fthf6glu e
species: metaM coa n
species: metaM cmp e
species: metaM co2 e
species: metaM 1pyr5c m
species: metaM chtn e
species: metaM thyox L e
species: metaM CE2420 m
species: metaM thp2c x
stoichiometry: 0.592114
species: metaM CE2705 n
species: metaM thcholstoic m
species: metaM ksii core4 pre6 g
species: metaM 3hibutcoa m
species: metaM clpndcoa x
species: metaM gly m
species: metaM 3aib D c
multipler: 1.0
species: metaM lnlncacoa c
species: metaM ala B e
species: metaM amet c
species: metaM thbpt4acam c
species: metaM ocdececrn c
species: metaM nadh x
species: metaM pacald c
species: metaM CE0693 m
species: metaM glyc c
species: metaM btcoa x
species: metaM pail34p hs c
species: metaM 4nph e
species: metaM rbt e
species: metaM fe2 c
species: metaM pmtcoa r
species: metaM pac c
species: metaM lnlc e
species: metaM dpcoa e
species: metaM h c
species: metaM c6dc c
species: metaM CE2417 m
species: metaM em2emgacpail hs r
species: metaM fgam c
species: metaM Rtotal3 e
species: metaM CE4872 m

http://identifiers.org/biomodels.db/MODEL1310110027#_0eac01e7_0949_4192_89c7_9071a432cffb
is encoded by: hsa:4720
type: Species
is: SBO:0000252
is: B7Z792
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: NDUFS2

metaR HMGLx
type: Reaction
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (3155.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:TV NJ added peroxisomal version - see Olivier Biochimica et Biophysica Act 1529 (2000) 89-102
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/4.1.3.4
is described by: ECO:0000134
reactant: MODEL1310110027#
is: SBO:0000176
reversible: false
product: MODEL1310110027#
fast: false
name: hydroxymethylglutaryl-CoA lyase

metaR NRPPHRSFt
type: Reaction
is: SBO:0000185
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB
reactant: MODEL1310110027#
is described by: ECO:0000000
reversible: false
fast: false
kinetic law: MODEL1310110027#
name: norepinephrine sulfate transport (diffusion)

http://identifiers.org/biomodels.db/MODEL1310110027#_a3895ae8_aa4f_4407_ae88_25d113d49694
boundary condition: true
has only substance units: false
name: UCK2
type: Species
is: Q9BZX2
constant: false
is encoded by: hsa:7371
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR ATPtx
product: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
reversible: true
reactant: MODEL1310110027#
name: ATP transporter, peroxisomal
is described by: ECO:0000000
is: SBO:0000185
fast: false

metaR ASNSERNaEx
name: L-serine/L-asparagine Na-dependent exchange (Asn-L in)
type: Reaction
kinetic law: MODEL1310110027#
is described by: ECO:0000269
modifier: MODEL1310110027#
is: SBO:0000185
reversible: false
product: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false

metaM stcoa c
name: Stearoyl-CoA (n-C18:0CoA)
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
constant: false
has only substance units: false
is: CHEBI:57394
type: Species
boundary condition: false
is: C00412
is: HMDB01114
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_9f8d8eef_4446_4edd_afa8_f8ac3b8ee564
is encoded by: hsa:54344
name: DPM3:DPM1:DPM2
has part: O94777
initial amount: NaN
is encoded by: hsa:8818
is encoded by: hsa:8813
is: SBO:0000297
has part: O60762
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
type: Species
has part: Q86TM7

metaR r1588
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110027#
type: Reaction
fast: false
reactant: MODEL1310110027#
product: MODEL1310110027#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110027#_a951ff00_4e92_433a_ba7e_1077080a4b93
constant: false
type: Species
initial concentration: NaN
boundary condition: true
is: Q6IBB5
name: NDUFA1
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:4694

metaM phe L e
is: CHEBI:17295
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
is: HMDB00159
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
initial concentration: 1.0
name: L-phenylalanine
initial amount: NaN

metaM sph1p c
has only substance units: false
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57939
boundary condition: false
type: Species
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
constant: false
is: HMDB01383
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_25bd34f8_7618_498c_a1ff_7fac6b17dc51
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:3632
is: Q14642
name: INPP5A

metaR CYTK14n
reversible: true
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110027#
name: cytidylate kinase (dCMP,CTP),nuclear
type: Reaction
reactant: MODEL1310110027#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110027#

metaM bilirub r
is: CHEBI:57977
is: HMDB00054
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
has only substance units: false
name: bilirubin(2-)

metaR FATP3t
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110027#
fast: false
name: fatty acid electroneutral transport
product: MODEL1310110027#
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ

metaR URIt5le
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
reversible: false
fast: false
is: SBO:0000185
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
modifier: MODEL1310110027#
name: uridine transport in via sodium symport (1:2)
is described by: ECO:0000134
type: Reaction

metaR M14NTg
product: MODEL1310110027#
type: Reaction
fast: false
is described by: ECO:0000000
modifier: MODEL1310110027#
name: beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
is: SBO:0000176
notes: GENE_ASSOCIATION: (4248.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.144 Confidence Level: 0 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.144
kinetic law: MODEL1310110027#
reversible: false
reactant: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_da32aed0_a217_4877_9702_dc88fd0c07b4
has only substance units: false
type: Species
name: SMPD3
initial amount: NaN
is: Q9NY59
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:55512
is: SBO:0000252

metaM tchola e
initial concentration: 1.0
is: HMDB00036
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
name: taurocholic acid
constant: false
notes: FORMULA: C26H45NO7S CHARGE: 0
initial amount: NaN

metaM 7dhchsterol c
constant: false
is: CHEBI:17759
initial concentration: 1.0
is: HMDB00032
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: cholesta-5,7-dien-3beta-ol
type: Species
boundary condition: false

metaM C02528 r
type: Species
constant: false
is: SBO:0000247
is: HMDB00518
is: CHEBI:36234
boundary condition: false
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
initial amount: NaN
name: chenodeoxycholate
initial concentration: 1.0
has only substance units: false

metaR EX fe2 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_fe2(u)
type: Reaction

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

metaR C6DCCACT
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of adipoyl carnitine into cytosol
type: Reaction

metaR UMPK3n
fast: false
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: UMP kinase (UTP),nuclear
reversible: true
product: MODEL1310110027#
modifier: MODEL1310110027#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR DCK2n
is version of: http://identifiers.org/ec-code/2.7.1.74
reversible: true
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
reactant: MODEL1310110027#
type: Reaction
name: Deoxycytidine kinase, nuclear (UTP)
is described by: ECO:0000269
kinetic law: MODEL1310110027#
fast: false
modifier: MODEL1310110027#
is: SBO:0000176

metaR GLYCTDle
name: difussion of glycerol accross the brush border membrane
product: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
type: Reaction
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110027#
is described by: ECO:0000134

metaR MANtly
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
name: mannose efflux from lysosome
kinetic law: MODEL1310110027#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110027#
type: Reaction
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110027#_db0eb3db_65ea_49c5_bb65_ff4fb49afa3c
initial amount: NaN
constant: false
type: Species
is: SBO:0000297
is encoded by: hsa:7991
boundary condition: true
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
initial concentration: NaN
has only substance units: false

metaR NP1
name: nucleotide phosphatase
reversible: false
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: NAD metabolism EC Number: 3.4.2.1 Confidence Level: 2 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.2.1
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
fast: false
modifier: MODEL1310110027#
is: SBO:0000176
product: MODEL1310110027#
type: Reaction

metaR MG3er
is: SBO:0000176
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
type: Reaction
reversible: false
reactant: MODEL1310110027#
product: MODEL1310110027#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
kinetic law: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_a8ebe299_6e96_4222_86ce_d2c4c3fdaaa0
name: NUDT12
is encoded by: hsa:83594
is: Q9BQG2
initial amount: NaN
has only substance units: false
type: Species
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110027#_dac3e86a_81e1_49a6_9db4_041b23858b7f
type: Species
boundary condition: true
is: Q9Y672
is encoded by: hsa:29929
constant: false
is: SBO:0000252
name: ALG6
initial concentration: NaN
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110027#_3bd21720_6345_45c9_a93e_f7e7fd1210d0
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:26289
constant: false
is: Q9Y6K8
name: AK5
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR H2O2tp
is described by: ECO:0000000
kinetic law: MODEL1310110027#
is: SBO:0000185
type: Reaction
name: hydrogen peroxide peroxisomal transport via diffusion
fast: false
reversible: true
reactant: MODEL1310110027#
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD

metaM ppi r
is: SBO:0000247
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial amount: NaN
type: Species
name: Diphosphate
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB00250
is: CHEBI:33019
is: C00013
has only substance units: false

metaM ctp n
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB00082
has only substance units: false
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: CHEBI:37563
initial concentration: 1.0
name: CTP(4-)
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110027#_3385c04c_b34f_411d_97ca_df7a76155f3f
is encoded by: hsa:5625
constant: false
has only substance units: false
boundary condition: true
is: O43272
initial concentration: NaN
name: PRODH
is: SBO:0000252
initial amount: NaN
type: Species

metaR DUTPDPn
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/3.6.1.23
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (1854.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.23 Confidence Level: 4 AUTHORS: PMID:12799180,PMID:8631816,PMID:9070952 NOTES:
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reversible: false
reactant: MODEL1310110027#
name: dUTP diphosphatase, nuclear
type: Reaction
is: SBO:0000176

metaR TCYNTt
is described by: ECO:0000000
product: MODEL1310110027#
name: Thiocyanate transport via diffusion (cytosol to extracellular)
reactant: MODEL1310110027#
fast: false
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
type: Reaction
is: SBO:0000185
reversible: false

metaR TRPt4
is described by: ECO:0000304
kinetic law: MODEL1310110027#
type: Reaction
is: SBO:0000185
product: MODEL1310110027#
reactant: MODEL1310110027#
name: L-tryptophan transport in via sodium symport
fast: false
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
modifier: MODEL1310110027#
reversible: false

metaR VITD3t2
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110027#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is taken up from peripheral cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
name: Vitamin D3 uptake
reversible: false
kinetic law: MODEL1310110027#
product: MODEL1310110027#

metaR PIPLCn
is version of: http://identifiers.org/ec-code/3.1.4.11
product: MODEL1310110027#
reversible: false
modifier: MODEL1310110027#
is described by: ECO:0000000
kinetic law: MODEL1310110027#
name: phosphatidylinositol phospholipase C, nucleus
is: SBO:0000176
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD
fast: false
type: Reaction

metaM ascb L e
boundary condition: false
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
initial concentration: 1.0
type: Species
is: CHEBI:38290
is: HMDB00044
has only substance units: false
initial amount: NaN
name: L-ascorbate
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_d4725f05_2fda_4c2a_895a_aa03fc18fc34
is: SBO:0000252
boundary condition: true
is encoded by: hsa:1738
has only substance units: false
name: DLD
initial amount: NaN
initial concentration: NaN
constant: false
is: P09622
type: Species

metaM ala L e
initial concentration: 1.0
type: Species
name: L-alanine
is: HMDB00161
has only substance units: false
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
initial amount: NaN
constant: false
is: CHEBI:16977
boundary condition: false

metaR 34HPPte
name: Transport of 3-(4-hydroxyphenyl)pyruvate
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
product: MODEL1310110027#
is: SBO:0000185
kinetic law: MODEL1310110027#
reversible: true
reactant: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_42cb48c4_9b86_44ad_acd6_b8c763d6ad5e
has only substance units: false
constant: false
name: PC
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5091
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110027#_f93635d7_d70d_4e9f_984e_42ef59a62a1a
is encoded by: hsa:2876
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
name: GPX1
initial amount: NaN
boundary condition: true

metaM ksi pre20 g
constant: false
name: keratan sulfate I biosynthesis, precursor 20
boundary condition: false
type: Species
notes: FORMULA: C171H274N12O140S6X CHARGE: -7
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:28067

metaR r0437
type: Reaction
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
is version of: http://identifiers.org/ec-code/4.1.2.13
is: SBO:0000176
kinetic law: MODEL1310110027#
fast: false
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110027#
reactant: MODEL1310110027#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21

metaM sph1p e
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
initial concentration: 1.0
initial amount: NaN
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
is: CHEBI:57939
has only substance units: false
constant: false
type: Species
is: SBO:0000247
is: HMDB01383
boundary condition: false

metaM glyphe e
type: Species
constant: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/97415
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
name: Glycylphenylalanine
notes: FORMULA: C11H14N2O3 CHARGE: 0

metaM coa c
has only substance units: false
is: SBO:0000247
is: C00010
notes: FORMULA: C21H32N7O16P3S CHARGE: -4
initial amount: NaN
constant: false
boundary condition: false
type: Species
is: HMDB01423
initial concentration: 1.0
name: Coenzyme A
is: CHEBI:3312

http://identifiers.org/biomodels.db/MODEL1310110027#_effc5f42_5b6b_48f8_adea_d70bd1820377
is encoded by: hsa:BG035985
initial amount: NaN
boundary condition: true
name: _BG035985_1_c
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
type: Species

metaR AG13T1g
is: SBO:0000176
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (374907.2) or (374907.1) or (146712.1) or (10331.1) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110027#
reversible: false
is described by: ECO:0000000
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus

metaR RE1796M
reversible: true
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
name: RE1796
is: SBO:0000176
fast: false
modifier: MODEL1310110027#
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.1.1.145
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000000
type: Reaction

metaM dtmp m
is: HMDB01227
initial amount: NaN
name: dTMP
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
is: CHEBI:26999
is: C00364
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_b42d87ad_fe50_4397_9ddc_187b297f6cb2
is encoded by: hsa:66035
constant: false
boundary condition: true
type: Species
name: SLC2A11
is: SBO:0000252
is: Q8WXF9
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM mag hs c
is: SBO:0000247
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
is: HMDB12130
has only substance units: false
initial concentration: 1.0
is: CHEBI:16987
name: monoacylglycerol 2
initial amount: NaN
boundary condition: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_96cee41d_62ef_4c1c_b853_781d208e4f0e
initial concentration: NaN
boundary condition: true
name: DCXR
is encoded by: hsa:51181
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: Q7Z4W1

http://identifiers.org/biomodels.db/MODEL1310110027#_bd5c1b0d_3089_4d29_a0dd_0b719625fca8
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:4715
boundary condition: true
name: NDUFB9
is: Q9Y6M9

metaM icit m
boundary condition: false
constant: false
is: SBO:0000247
name: Isocitrate
is: HMDB00193
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
is: C00311
initial amount: NaN
has only substance units: false
is: CHEBI:16087
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_983f9b37_8070_4b0c_8d94_5505b5028ef1
is: P80404
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:18
constant: false
name: ABAT
type: Species
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110027#_1b88a91f_1a0d_4477_92af_5650c41ee1f1
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: _100128062_1_m
is encoded by: hsa:100128062
boundary condition: true

metaR AICART
modifier: MODEL1310110027#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
is version of: http://identifiers.org/ec-code/2.1.2.3
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110027#
name: phosphoribosylaminoimidazolecarboxamide formyltransferase
reactant: MODEL1310110027#
product: MODEL1310110027#

metaR r2017
modifier: MODEL1310110027#
reversible: false
fast: false
product: MODEL1310110027#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110027#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110027#_fa831deb_725e_4c19_a708_98d5504684f0
is encoded by: hsa:23428
initial concentration: NaN
name: SLC7A8
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
constant: false
is: Q9UHI5

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_af23945e_88ff_468a_91b4_b5e57a51aaa3
is encoded by: hsa:215
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
is: P33897
name: ABCD1

metaR P450SCC1m
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
reactant: MODEL1310110027#
type: Reaction
is: SBO:0000176
name: cholesterol monooxygenase
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110027#_1ddf1317_2a8a_4acd_a0ba_99d4ab2cbe31
initial concentration: NaN
name: PPA1
is: Q15181
is: SBO:0000252
is encoded by: hsa:5464
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
constant: false

metaM retinol c
boundary condition: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
is: CHEBI:50211
constant: false
name: retinol
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB00305

http://identifiers.org/biomodels.db/MODEL1310110027#_ee5ed8cc_82a7_4735_bd3d_76f3f4fd9022
is: Q92835
is encoded by: hsa:3635
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
name: INPP5D
constant: false

metaM ksi pre5 g
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 5
is: CHEBI:28067
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C101H164N7O75SX CHARGE: -2
has only substance units: false
boundary condition: false

metaM gsn c
name: Guanosine
is: C00387
is: HMDB00133
constant: false
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:16750
is: SBO:0000247
has only substance units: false

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_96b0b22f_1a08_4601_bbfc_d5a4f9809149
is: SBO:0000252
type: Species
boundary condition: true
name: PAPSS1
initial amount: NaN
is encoded by: hsa:9061
has only substance units: false
constant: false
is: O43252
initial concentration: NaN

metaR PGDI
is version of: http://identifiers.org/ec-code/5.3.99.2
is version of: http://identifiers.org/ec-code/2.5.1.18
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
reversible: true
type: Reaction
modifier: MODEL1310110027#
name: Prostaglandin-H2 D-isomerase [Precursor]
product: MODEL1310110027#
fast: false

metaR ACCOAtn
reversible: true
product: MODEL1310110027#
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
fast: false
reactant: MODEL1310110027#
is described by: ECO:0000000
is: SBO:0000185
name: acetyl-CoA transport, nuclear

metaM dcmp n
is: HMDB01202
is: SBO:0000247
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:57566
boundary condition: false
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
name: dCMP(2-)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_23a03039_4df6_4262_b7a3_42f5359229ff
boundary condition: true
initial amount: NaN
type: Species
constant: false
name: SHMT2
has only substance units: false
is encoded by: hsa:6472
is: B4DJQ3
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_ae150bdb_7260_467f_8684_2a66a289c184
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
name: ACAA2
is encoded by: hsa:10449
is: P42765

http://identifiers.org/biomodels.db/MODEL1310110027#_433d99bd_482f_47a7_9f11_bd04c5289cb5
is encoded by: hsa:1103
boundary condition: true
is: Q6LEN6
initial amount: NaN
name: CHAT
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110027#_3e3a5c10_4dd1_43db_9b9a_cb739c1ae08f
is encoded by: hsa:2582
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
is: Q14376
initial amount: NaN
name: GALE

metaM ctp e
is: SBO:0000247
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
boundary condition: false
is: CHEBI:37563
initial concentration: 1.0
name: CTP(4-)
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: HMDB00082

metaR r0650
is: SBO:0000176
reversible: true
type: Reaction
modifier: MODEL1310110027#
is version of: http://identifiers.org/ec-code/4.1.1.36
product: MODEL1310110027#
fast: false
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
is described by: ECO:0000000
reactant: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_a0b9966f_6906_4f53_9c95_db9e520dfc3c
has only substance units: false
initial amount: NaN
is: Q9H553
boundary condition: true
is: SBO:0000252
constant: false
name: ALG2
type: Species
is encoded by: hsa:85365
initial concentration: NaN

metaM 3ddecdicoa m
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: C05280
initial concentration: 1.0
constant: false
name: 3,6-dodecadienoylcoa
boundary condition: false
is: HMDB03952
type: Species

metaM hedepecoa m
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
name: 2,4,7,10,13-hexadecapentenoylcoa
is: SBO:0000247
notes: FORMULA: C37H52N7O17P3S CHARGE: -4
is: HMDB02288

metaM pchol hs e
initial amount: NaN
name: Phosphatidylcholine
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false
constant: false
is: CHEBI:16110
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110027#_67ec3dbb_4c79_4c5a_9c7b_93c319a69240
type: Species
has only substance units: false
name: _AI480132_1_c
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AI480132

http://identifiers.org/biomodels.db/MODEL1310110027#_647f5671_c94d_45f0_baa6_7f1c0f53fa32
has only substance units: false
is encoded by: hsa:NOS2A
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: _NOS2A_1_c
type: Species

http://identifiers.org/biomodels.db/MODEL1310110027#_1c20fa60_0799_436d_af1e_4011d1eb9c91
has only substance units: false
constant: false
is: Q6LEN5
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:1103
name: CHAT
initial amount: NaN

metaM HC01610 e
initial concentration: 1.0
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768
initial amount: NaN
name: CoproporphyrinogenI
is: CHEBI:28607
has only substance units: false
boundary condition: false
constant: false
type: Species
is: SBO:0000247

metaM galgluside hs g
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB00295
initial amount: NaN
constant: false
is: C00015
name: galactosyl glucosyl ceramide
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
is: CHEBI:58223
type: Species

metaM retfa c
initial amount: NaN
is: HMDB00305
is: CHEBI:50211
type: Species
name: fatty acid retinol
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110027#_22a83b2a_b7de_43aa_b411_926a471e3dc7
is encoded by: hsa:T83654
name: _T83654_1_e
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN

metaM oh1 c
type: Species
notes: FORMULA: HO CHARGE: -1
is: C01328
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: hydroxide ion
constant: false
is: HMDB01039
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_fb8956a9_a597_49f2_bdeb_d52bb953d8ab
name: _HG2846_HT2983_1_c
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:HG2846-HT2983
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR SERTHRNaEx
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-serine/L-threonine Na-dependent exchange (Ser-L in)
product: MODEL1310110027#
reversible: false
reactant: MODEL1310110027#
fast: false
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_d1456fe7_ce3e_45ec_9779_c5385f016036
is: E7EUT4
is: SBO:0000252
constant: false
is encoded by: hsa:2597
initial concentration: NaN
initial amount: NaN
name: GAPDH
has only substance units: false
type: Species
boundary condition: true

metaR PRO Dtde
fast: false
reactant: MODEL1310110027#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110027#
reversible: true
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
is described by: ECO:0000134
name: D-proline transport, extracellular

http://identifiers.org/biomodels.db/MODEL1310110027#_b258abf3_1899_4386_98cb_fb281e9af774
initial amount: NaN
boundary condition: true
type: Species
has part: P00338
name: LDHA:LDHB
constant: false
is encoded by: hsa:3939
has part: P07195
is encoded by: hsa:3945
initial concentration: NaN
has only substance units: false
is: SBO:0000297

metaR PVD3
reversible: true
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110027#
name: Previtamin D3 formation
product: MODEL1310110027#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:6281884 NOTES:This reaction takes place in skin and needs UV 290-305. based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
reactant: MODEL1310110027#

metaM c4dc e
constant: false
is: HMDB02013
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: succinyl carnitine
is: http://identifiers.org/pubchem.compound/213144
notes: FORMULA: C11H18NO6 CHARGE: -1
boundary condition: false
type: Species
is: C02862
is: SBO:0000247

metaR FAOXC161C141m
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:1-->C14:1)m
type: Reaction

metaR CYTDn
is described by: ECO:0000254
is: SBO:0000176
name: cytidine deaminase, nuclear
modifier: MODEL1310110027#
reactant: MODEL1310110027#
reversible: false
is version of: http://identifiers.org/ec-code/3.5.4.5
kinetic law: MODEL1310110027#
type: Reaction
fast: false
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.5 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:

metaR RNDR1
is described by: ECO:0000254
is: SBO:0000176
kinetic law: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.17.4.1
reversible: false
type: Reaction
reactant: MODEL1310110027#
modifier: MODEL1310110027#
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
fast: false
name: ribonucleoside-diphosphate reductase (ADP)

http://identifiers.org/biomodels.db/MODEL1310110027#_2bc122de_0b99_470f_a060_74f034915139
name: GSR
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:2936
is: SBO:0000252
constant: false
is: P00390
boundary condition: true
initial concentration: NaN

metaM HC02180 c
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
constant: false
is: CHEBI:28728
initial concentration: 1.0
has only substance units: false
name: thromboxane-b2
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_68929a92_a2fe_4bd6_bfd7_56e6c558dfcd
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
is: O95622
is encoded by: hsa:111
constant: false
has only substance units: false
initial concentration: NaN
name: ADCY5

http://identifiers.org/biomodels.db/MODEL1310110027#_c5a9f258_61e9_49fc_afc0_fd4a39e148ac
constant: false
is encoded by: hsa:5295
name: PIK3CA:PIK3R1
initial amount: NaN
has only substance units: false
initial concentration: NaN
has part: P27986
boundary condition: true
type: Species
is: SBO:0000297

metaR r1883
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110027#
reversible: false
modifier: MODEL1310110027#
fast: false
type: Reaction
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_440aa286_6b73_43d5_914d_ed6becb18a4f
name: ACAT2
is encoded by: hsa:39
is: SBO:0000252
constant: false
initial amount: NaN
is: Q9BWD1
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN

metaR C10DCc
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoylcarnitine
type: Reaction

metaM HC01401 m
name: (S)-3-Hydroxydodecanoyl-CoA
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
is: CHEBI:27668
boundary condition: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110027#_b8685b0a_c36f_40ab_963d_949a6b2059ec
name: SLC6A2
type: Species
is: Q96KH8
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6530

metaM icit c
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB00193
is: CHEBI:16087
name: Isocitrate
type: Species
is: C00311
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311

metaR RE1845C
is: SBO:0000176
product: MODEL1310110027#
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/2.3.1.65
is described by: ECO:0000000
name: RE1845
fast: false
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 4 h[c] from compEHMN reaction as they were not necessary
modifier: MODEL1310110027#
type: Reaction
reversible: true

metaR MI1P Dtn
is: SBO:0000185
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
kinetic law: MODEL1310110027#
name: inositol 1-phosphate nuclear transport (diffusion)
reactant: MODEL1310110027#
fast: false

metaR C4DCe
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of succinyl carnitine into the extra cellular space
type: Reaction

metaR EX lnlncg LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gamma-linolenic acid exchange
type: Reaction

metaR 6HTSTSTERONEte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, inactivated testosterone needs to be exported NJ
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110027#
fast: false
type: Reaction
reversible: true
name: hydroxylated testosterone transport

metaR r2308
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110027#
is described by: ECO:0000000
kinetic law: MODEL1310110027#
reversible: true
product: MODEL1310110027#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_83af14e3_9f55_445c_9fb7_8f54e0a42176
name: UPP1
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:7378
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_44225135_4d0c_492d_bdd7_7efdc9a6a47a
is: SBO:0000252
is encoded by: hsa:205
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
name: AK4
boundary condition: true
has only substance units: false

metaM ctp c
is: C00063
boundary condition: false
is: SBO:0000247
is: CHEBI:37563
initial concentration: 1.0
name: CTP
has only substance units: false
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
type: Species
initial amount: NaN
is: HMDB00082
constant: false

http://identifiers.org/biomodels.db/MODEL1310110027#_be0a68de_d100_4011_9b9e_646c59324613
constant: false
type: Species
is encoded by: hsa:158
has only substance units: false
name: ADSL
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR RNDR2
name: ribonucleoside-diphosphate reductase (GDP)
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
reversible: false
is: SBO:0000176
modifier: MODEL1310110027#
type: Reaction
reactant: MODEL1310110027#
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/1.17.4.1
fast: false
kinetic law: MODEL1310110027#
product: MODEL1310110027#

metaR HMGCOARc
reactant: MODEL1310110027#
fast: false
product: MODEL1310110027#
kinetic law: MODEL1310110027#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.1.1.34
is: SBO:0000176
type: Reaction
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). enzyme is located in E.R. but has catalytic site facing the cytosol (D.S. Sheriff (2004) Medical biochemistry, 1st edition Jaypee brothers Medical publishers pvt ltd page 502).
name: Hydroxymethylglutaryl CoA reductase (ir) in cytosol
reversible: false

metaR r1886
fast: false
type: Reaction
is: SBO:0000185
reversible: false
modifier: MODEL1310110027#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110027#
product: MODEL1310110027#
is described by: ECO:0000000
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110027#_4701d998_db55_4bc0_a451_0fe48dea6f97
name: _AI769281_1_e
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AI769281
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110027#_68d06f13_adca_42e0_be59_f52ba721cb57
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:AA177072
boundary condition: true
initial concentration: NaN
name: _AA177072_1_c

http://identifiers.org/biomodels.db/MODEL1310110027#_c6d11a1d_670d_492a_abac_327507de5dff
constant: false
is: Q9HBH5
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:57665
type: Species
name: RDH14
is: SBO:0000252
boundary condition: true

metaM ppi m
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
name: Diphosphate
is: C00013
initial concentration: 1.0
type: Species
is: CHEBI:33019
is: HMDB00250
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110027#_fe59380a_0748_4f4c_b857_a233f97518f5
has only substance units: false
is encoded by: hsa:55229
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
type: Species
name: PANK4
is: Q9NVE7

http://identifiers.org/biomodels.db/MODEL1310110027#_27a65df2_f9f6_419e_892a_ad7582bf3ab8
constant: false
initial amount: NaN
is: SBO:0000252
name: CRAT
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1384
has only substance units: false
type: Species

metaR ASNtN1
product: MODEL1310110027#
kinetic law: MODEL1310110027#
reversible: true
name: Asparagine transport (Na, H coupled)
type: Reaction
reactant: MODEL1310110027#
modifier: MODEL1310110027#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is described by: ECO:0000269
is: SBO:0000185
fast: false

metaM pglyc hs c
boundary condition: false
initial concentration: 1.0
is: HMDB00156
is: SBO:0000247
has only substance units: false
constant: false
type: Species
is: CHEBI:15589
name: pglyc_hs[c]
initial amount: NaN
notes: FORMULA: CHARGE: 0

metaR r2099
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110027#
product: MODEL1310110027#
modifier: MODEL1310110027#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110027#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110027#_feb82561_22ca_4a13_9278_8851b2d2a24e
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:84890
boundary condition: true
initial concentration: NaN
is: B3KXN9
has only substance units: false
constant: false
name: ADO

http://identifiers.org/biomodels.db/MODEL1310110027#_6802d549_730a_4df7_8a58_bcbb91666227
is: SBO:0000252
is: Q9HCR9
constant: false
type: Species
is encoded by: hsa:50940
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: PDE11A

metaM oh1 e
type: Species
is: C01328
initial amount: NaN
notes: FORMULA: HO CHARGE: -1
boundary condition: false
constant: false
is: HMDB01039
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: hydroxide ion

http://identifiers.org/biomodels.db/MODEL1310110027#_86144ffe_129e_417c_bad6_7f98b3426d72
is encoded by: hsa:11332
boundary condition: true
type: Species
initial amount: NaN
constant: false
name: ACOT7
is: SBO:0000252
is: O00154
initial concentration: NaN
has only substance units: false

metaM amp r
is: HMDB00045
boundary condition: false
is: SBO:0000247
is: CHEBI:456215
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
has only substance units: false
constant: false
is: C00020
initial amount: NaN
name: AMP
type: Species
initial concentration: 1.0

metaR r2309
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
product: MODEL1310110027#
reactant: MODEL1310110027#
is described by: ECO:0000000
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110027#
fast: false

metaR UGCG
modifier: MODEL1310110027#
product: MODEL1310110027#
name: Ceramide glucosyltransferase
reversible: false
is: SBO:0000176
reactant: MODEL1310110027#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.80
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (7357.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES:NJ
kinetic law: MODEL1310110027#

metaR NACHEXA21ly
name: beta-N-acetylhexosaminidase A, lysosomal
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
reversible: false
reactant: MODEL1310110027#
fast: false
product: MODEL1310110027#

metaM HC02180 e
boundary condition: false
constant: false
is: CHEBI:28728
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
initial concentration: 1.0
type: Species
is: SBO:0000247
name: thromboxane-b2
has only substance units: false
initial amount: NaN

metaR RNDR3
type: Reaction
reactant: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.17.4.1
kinetic law: MODEL1310110027#
reversible: false
product: MODEL1310110027#
modifier: MODEL1310110027#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 4 AUTHORS: PMID:14729598 NOTES:
is: SBO:0000176
name: ribonucleoside-diphosphate reductase (CDP)

metaM HC02203 e
is: CHEBI:27820
boundary condition: false
has only substance units: false
name: prostaglandin-a2
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR GDPFUCtg
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (55343.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11326279,PMID:11326280 NOTES:NCD
fast: false
name: GDPFuc Golgi transport via CMP antiport
reversible: true
reactant: MODEL1310110027#
is: SBO:0000185
modifier: MODEL1310110027#
product: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#

metaM citr L c
initial amount: NaN
has only substance units: false
is: HMDB00904
is: SBO:0000247
constant: false
initial concentration: 1.0
name: L-citrulline
type: Species
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
boundary condition: false
is: CHEBI:16349

metaM leuktrA4 e
name: leukotriene A4(1-)
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57463
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
has only substance units: false
is: HMDB01337
boundary condition: false
type: Species
is: SBO:0000247
constant: false

metaM ppi n
initial concentration: 1.0
boundary condition: false
name: diphosphate(3-)
is: SBO:0000247
type: Species
is: CHEBI:33019
is: HMDB00250
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial amount: NaN
has only substance units: false
constant: false

metaR r0651
fast: false
is described by: ECO:0000000
reactant: MODEL1310110027#
modifier: MODEL1310110027#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
is: SBO:0000176
type: Reaction
reversible: true
product: MODEL1310110027#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.2
kinetic law: MODEL1310110027#

metaM 6thf e
initial concentration: 1.0
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1
constant: false
name: hexaglutamyl folate (THF)
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/169691

http://identifiers.org/biomodels.db/MODEL1310110027#_452dfde6_651d_4c78_aee0_af6c2b56a6ea
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:9963
is: SBO:0000252
boundary condition: true
name: SLC23A1
has only substance units: false

metaR PROt2r
is described by: ECO:0000304
product: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
name: L-proline reversible transport via proton symport
reactant: MODEL1310110027#
reversible: true
fast: false
is: SBO:0000185
modifier: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_a54b18c2_6374_49df_91be_5e1c2763c196
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
constant: false
name: PIGC
is: SBO:0000252
is encoded by: hsa:5279

metaM pro L m
initial concentration: 1.0
type: Species
initial amount: NaN
name: L-proline
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB00162
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
boundary condition: false
is: CHEBI:17203

metaR INSTt4
fast: false
reversible: true
name: inositol transport via sodium symport
type: Reaction
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD
is described by: ECO:0000269
product: MODEL1310110027#
modifier: MODEL1310110027#
is: SBO:0000185
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#

metaM HC01434 m
type: Species
name: oxalatosuccinate(3-)
initial amount: NaN
boundary condition: false
is: CHEBI:58931
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110027#_109f335e_3f6f_4838_a5a2_d4010175e194
initial concentration: NaN
name: _HG2846_HT2983_1_m
type: Species
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:HG2846-HT2983
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_162df179_b3f3_4347_9b6b_4ccb92db8698
initial concentration: NaN
is encoded by: hsa:65263
is: Q53H96
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
name: PYCRL
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_7d751422_9bdb_4ab1_84fb_36e9dcf3d5a5
has only substance units: false
boundary condition: true
is encoded by: hsa:4860
initial concentration: NaN
constant: false
initial amount: NaN
is: P00491
is: SBO:0000252
type: Species
name: PNP

metaM retn c
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:35291
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
boundary condition: false
is: HMDB01852
has only substance units: false
name: all-trans-retinoate

http://identifiers.org/biomodels.db/MODEL1310110027#_2cbea0a5_a2e6_4818_a037_8955cfeff1f5
initial concentration: NaN
is encoded by: hsa:AA419122
name: _AA419122_1_c
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
type: Species

metaR NADHtru
product: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
reactant: MODEL1310110027#
reversible: false
type: Reaction
name: NADH transporter, endoplasmic reticulum
kinetic law: MODEL1310110027#
is: SBO:0000185
fast: false
is described by: ECO:0000000

metaM dadp n
is: CHEBI:57667
is: HMDB01508
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
name: dADP(3-)

http://identifiers.org/biomodels.db/MODEL1310110027#_83f7ff78_24bf_43ec_97c1_624fe8a6d5f4
boundary condition: true
name: GALNT12
is encoded by: hsa:79695
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
is: Q8IXK2

http://identifiers.org/biomodels.db/MODEL1310110027#_3845b102_a413_4214_8410_29f8a0b76250
has only substance units: false
is: Q86YT5
constant: false
initial concentration: NaN
is: SBO:0000252
name: SLC13A5
is encoded by: hsa:284111
boundary condition: true
initial amount: NaN
type: Species

metaR BILIRUBt2
modifier: MODEL1310110027#
type: Reaction
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
is described by: ECO:0000269
name: bilirubin transport via bicarbonate countertransport
product: MODEL1310110027#
fast: false
reactant: MODEL1310110027#
reversible: true
is: SBO:0000185

metaR TKT1
reactant: MODEL1310110027#
fast: false
modifier: MODEL1310110027#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.2.1.1
is described by: ECO:0000000
name: transketolase
product: MODEL1310110027#
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110027#_3c4d7921_1cdc_4505_8c7e_d611e62235f2
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
is: Q53F23
initial concentration: NaN
name: TBXAS1
has only substance units: false
boundary condition: true
is encoded by: hsa:6916

metaR IMPC
reversible: true
modifier: MODEL1310110027#
fast: false
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 3.5.4.10 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
name: IMP cyclohydrolase
type: Reaction
is: SBO:0000176
product: MODEL1310110027#
kinetic law: MODEL1310110027#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.2.3

metaM 3pg c
is: http://identifiers.org/pubchem.compound/3497
is: HMDB00807
initial concentration: 1.0
name: 3-Phospho-D-glycerate
initial amount: NaN
has only substance units: false
is: CHEBI:58272
type: Species
is: C00197
constant: false
is: SBO:0000247
boundary condition: false

metaR r1580
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reversible: true
fast: false
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110027#_200b1c68_a658_4d46_8955_d67cbf308086
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:29920
initial concentration: NaN
constant: false
type: Species
name: PYCR2
is: Q96C36

metaR TXA2te
fast: false
name: thromboxane A2 transport
is: SBO:0000185
reactant: MODEL1310110027#
kinetic law: MODEL1310110027#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism for transport - known to be secreted from cells - unknown mechanism or pathway, TXA2tc -> TXA2te to get to EC space NJ
reversible: true
product: MODEL1310110027#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_a765c866_9a91_4563_b8b7_3e59567fedfe
initial amount: NaN
has only substance units: false
is: Q9Y2A9
constant: false
is encoded by: hsa:10331
name: B3GNT3
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110027#_166b43e9_142c_4f30_bfca_f0e9af8a3f58
initial amount: NaN
name: _AI440329_1_r
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AI440329
constant: false
type: Species

metaR DM 13 cis retn n
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: 13-cis-retinoate demand
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_2ad2bd60_3622_49f2_a888_ea04fe164335
boundary condition: true
has only substance units: false
constant: false
type: Species
name: UPP1
is: Q16831
initial amount: NaN
is encoded by: hsa:7378
initial concentration: NaN
is: SBO:0000252

metaM amp x
is: HMDB00045
boundary condition: false
initial amount: NaN
is: C00020
initial concentration: 1.0
is: CHEBI:456215
is: SBO:0000247
constant: false
name: AMP
has only substance units: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
type: Species

metaM dolmanp L r
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:15809
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
initial concentration: 1.0
name: Dolichyl phosphate D-mannose, human liver homolog
type: Species

metaR RE1796R
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
product: MODEL1310110027#
is version of: http://identifiers.org/ec-code/1.1.1.145
fast: false
is: SBO:0000176
kinetic law: MODEL1310110027#
name: RE1796
reversible: true
reactant: MODEL1310110027#
modifier: MODEL1310110027#
type: Reaction

metaM dca e
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB00705
constant: false
notes: FORMULA: C10H19O2 CHARGE: -1
has only substance units: false
type: Species
name: Decanoate (n-C10:0)

http://identifiers.org/biomodels.db/MODEL1310110027#_047744b1_380a_4b29_aec9_59a9ecf5fe82
initial amount: NaN
name: DPM2
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:8818
boundary condition: true
constant: false
is: SBO:0000252

metaR PLA2 2e
reversible: false
type: Reaction
fast: false
kinetic law: MODEL1310110027#
notes: GENE_ASSOCIATION: (5322.1) or (5319.1) or (81579.1) or (64600.1) or (26279.1) or (5320.1) or (8399.1) or (30814.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:10455175,PMID:10681567,PMID:11031251,PMID:11112443,PMID:8300559,PMID:9188469,PMID:9272153,PMID:9886417 NOTES:phosphatidyl choline degradation NJ
name: phospholipase A2
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.1.4
is described by: ECO:0000000
reactant: MODEL1310110027#
product: MODEL1310110027#
modifier: MODEL1310110027#

metaR EX gam LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Glucosamine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_eafca6b4_d393_49d6_b11d_304e604c0587
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: _AA977580_1_c
type: Species
is encoded by: hsa:AA977580
initial amount: NaN

metaM ncam e
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:0
is: C00153
initial concentration: 1.0
is: HMDB01406
is: SBO:0000247
notes: FORMULA: C6H6N2O CHARGE: 0
boundary condition: false
name: Nicotinamide
constant: false

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

metaM retn e
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01852
is: CHEBI:35291
name: all-trans-retinoate
constant: false
has only substance units: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777

http://identifiers.org/biomodels.db/MODEL1310110027#_5ec3cc2f_d9d8_439e_bac5_6e940f47ed78
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
name: SGPL1
has only substance units: false
is: O95470
is encoded by: hsa:8879

metaR EX 5thf LPAREN e RPAREN
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (THF) exchange
type: Reaction

metaM dadp m
has only substance units: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
initial concentration: 1.0
boundary condition: false
is: CHEBI:57667
name: dADP(3-)
is: HMDB01508
type: Species
is: SBO:0000247
initial amount: NaN
constant: false

metaM HC02203 c
type: Species
name: prostaglandin-a2
has only substance units: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
is: CHEBI:27820
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaR r1581
type: Reaction
kinetic law: MODEL1310110027#
product: MODEL1310110027#
reversible: true
reactant: MODEL1310110027#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110027#_1b1accad_852f_439c_b0fb_7aca670a7a75
has only substance units: false
is: SBO:0000252
name: ITPKA
type: Species
constant: false
initial concentration: NaN
is: P23677
boundary condition: true
is encoded by: hsa:3706
initial amount: NaN

metaR B MANNASEly
name: beta-mannosidase, lysosomal
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110027#
modifier: MODEL1310110027#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.25
reactant: MODEL1310110027#
reversible: false
notes: GENE_ASSOCIATION: (4126.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.25 Confidence Level: 0 AUTHORS: PMID:9384606 NOTES:NCD
product: MODEL1310110027#

metaR PItx
kinetic law: MODEL1310110027#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is: SBO:0000185
name: Phosphate transporter, peroxisome
fast: false
reactant: MODEL1310110027#
type: Reaction
product: MODEL1310110027#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110027#_8d055f0c_8c5e_425c_8572_521cf90040f0
boundary condition: true
constant: false
is: P04745
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
name: AMY1B
is encoded by: hsa:277

http://identifiers.org/biomodels.db/MODEL1310110027#_1d0044e2_5163_43b1_8b40_dbce2300572e
is encoded by: hsa:80271
has only substance units: false
name: ITPKC
type: Species
boundary condition: true
is: SBO:0000252
is: Q96DU7
initial concentration: NaN
initial amount: NaN
constant: false

metaM HC02207 e
type: Species
boundary condition: false
constant: false
has only substance units: false
name: prostaglandin-c2
initial amount: NaN
initial concentration: 1.0
is: CHEBI:27555
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955

metaR PRISTCOAtx
kinetic law: MODEL1310110027#
reactant: MODEL1310110027#
name: pristcoa peroxisomal transport
is described by: ECO:0000000
fast: false
product: MODEL1310110027#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110027#_cec6eea9_0997_4050_95b7_d7b39ce31455
name: SULT1A2
initial amount: NaN
boundary condition: true
is encoded by: hsa:6799
is: SBO:0000252
constant: false
has only substance units: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_ed38c9fa_d64c_466a_bf8e_09047dd1275a
is: SBO:0000252
initial amount: NaN
constant: false
is: Q8N3E9
name: PLCD3
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:113026
boundary condition: true

metaM thym c
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: Thymine
is: C00178
constant: false
initial concentration: 1.0
is: CHEBI:17821
type: Species
notes: FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
is: HMDB00262
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110027#_13b657b2_4d48_433d_9b23_c06e491ab972
name: ST3GAL3
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:6487
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110027#_bb59cedb_9cd0_4b36_bbdd_438b24667764
is encoded by: hsa:AA614647
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: _AA614647_1_c
constant: false
type: Species

metaR r2200
fast: false
type: Reaction
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110027#
kinetic law: MODEL1310110027#
is described by: ECO:0000000
modifier: MODEL1310110027#
reversible: true
reactant: MODEL1310110027#

http://identifiers.org/biomodels.db/MODEL1310110027#_dffaf101_d0a0_4e43_9e04_2d95ec104dad
initial concentration: NaN
boundary condition: true
is encoded by: hsa:53354
constant: false
type: Species
is: SBO:0000252
is: Q8TE04
name: PANK1
has only substance units: false
initial amount: NaN

metaM fe3 e
is: HMDB12943
name: Fe3+
is: SBO:0000247
is: CHEBI:29034
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: Fe CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC01847
initial concentration: 1.0

metaM 3hexdtricoa m
constant: false
name: 3,7,10-hexadecatrienoylcoa
boundary condition: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
is: HMDB02288
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110027#_68a9998a_2b38_4d84_a696_5c6dda50f7ef
is encoded by: hsa:641649
constant: false
boundary condition: true
is: SBO:0000252
is: C9JZ62
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
name: TMEM91

metaR r0656
product: MODEL1310110027#
name: 3-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(3-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
fast: false
kinetic law: MODEL1310110027#
is described by: ECO:0000000
reactant: MODEL1310110027#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
type: Reaction

metaM ala L m
is: SBO:0000247
type: Species
initial concentration: 1.0
name: L-alanine
initial amount: NaN
is: CHEBI:16977
is: HMDB00161
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
constant: false
boundary condition: false

metaM Rtotal2coa c
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4
name: R total 2 coenzyme A
is: CHEBI:60377
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB00095
constant: false
is: C00055
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110027#_1be672d0_9566_4e2f_964a_4938fc7280b8
has only substance units: false
is: SBO:0000252
is: P47712
constant: false
name: PLA2G4A
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5321
boundary condition: true

metaR r2521
reactant: MODEL1310110027#
fast: false
type: Reaction
kinetic law: MODEL1310110027#
name: Utilized transport
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
product: MODEL1310110027#
is: SBO:0000185

ORG:
  orgname: University of Iceland