metaM gal c
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB00143
is: CHEBI:0
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0
initial amount: NaN
type: Species
name: D-Galactose
constant: false
is: C00124

http://identifiers.org/biomodels.db/MODEL1310110026#_225903c2_9aa0_4671_ac67_78ee2340144b
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:55361
constant: false
has only substance units: false
boundary condition: true
name: PI4K2A
is: Q9BTU6

http://identifiers.org/biomodels.db/MODEL1310110026#_1160438c_6489_43b4_afe1_cd673e823f37
initial amount: NaN
initial concentration: NaN
name: SLC26A11
is encoded by: hsa:284129
type: Species
is: Q86WA9
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR THRGLNexR
type: Reaction
name: L-threonine/glycine reversible exchange
is described by: ECO:0000304
product: MODEL1310110026#
reactant: MODEL1310110026#
modifier: MODEL1310110026#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_1fe9c0ce_60c3_43b7_aa83_c5cccb5e1e28
is: B3KU59
has only substance units: false
is encoded by: hsa:6547
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: SLC8A3
constant: false
is: SBO:0000252

metaR r1384
is: SBO:0000176
fast: false
name: Guanosine aminohydrolase EC:3.5.4.15
product: MODEL1310110026#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
reactant: MODEL1310110026#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110026#

metaM lgnccoa c
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C45H78N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H82N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h32-34,38-40,44,55-56H,4-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/t34-,38?,39-,40+,44-/m1/s1
name: lignocericyl coenzyme A
type: Species
constant: false
is: HMDB06526
initial concentration: 1.0
has only substance units: false

metaM dmhptcoa m
initial amount: NaN
is: HMDB06258
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C30H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C30H52N7O17P3S/c1-17(2)7-6-8-18(3)29(42)58-12-11-32-20(38)9-10-33-27(41)24(40)30(4,5)14-51-57(48,49)54-56(46,47)50-13-19-23(53-55(43,44)45)22(39)28(52-19)37-16-36-21-25(31)34-15-35-26(21)37/h15-19,22-24,28,39-40H,6-14H2,1-5H3,(H,32,38)(H,33,41)(H,46,47)(H,48,49)(H2,31,34,35)(H2,43,44,45)/p-4/t18-,19+,22-,23-,24?,28+/m0/s1
boundary condition: false
type: Species
constant: false
name: 2,6 dimethylheptanoyl-CoA

metaM vitd3 e
initial amount: NaN
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
type: Species
initial concentration: 1.0
is: HMDB00876
constant: false
is: CHEBI:28940
boundary condition: false
has only substance units: false
name: calciol
is: SBO:0000247

metaM HC00250 e
constant: false
name: hydrosulfide
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
is: CHEBI:29919
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaR PROSTGI2tr
fast: false
is: SBO:0000185
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
type: Reaction
name: Prostaglandin I2 transport (ER)
is described by: ECO:0000269

metaR GLYt7 311 r
modifier: MODEL1310110026#
product: MODEL1310110026#
is: SBO:0000185
fast: false
is described by: ECO:0000006
name: glycine reversible transport via sodium and chloride symport (3:1:1)
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB

metaR TTDCAtr
fast: false
type: Reaction
kinetic law: MODEL1310110026#
is described by: ECO:0000269
reactant: MODEL1310110026#
name: tetradecanoate (transport)
product: MODEL1310110026#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
reversible: true

metaM gpi sig r
notes: FORMULA: Y CHARGE: 0
is: HMDB00224
constant: false
name: glycophosphatidylinositol (GPI) signal sequence (C-terminal peptide)
initial concentration: 1.0
is: CHEBI:58190
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_6fdc78c0_8862_4963_932a_4c6e96aa7b7d
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:3032
constant: false
initial amount: NaN
name: HADHB
is: P55084
is: SBO:0000252

metaR AKR1C41
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.225
is: SBO:0000176
kinetic law: MODEL1310110026#
type: Reaction
name: aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
is described by: ECO:0000269
modifier: MODEL1310110026#
product: MODEL1310110026#
reversible: false
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 4 AUTHORS: NOTES:NJ

metaM malttr e
has only substance units: false
is: HMDB01262
initial concentration: 1.0
is: CHEBI:27931
boundary condition: false
is: SBO:0000247
is: C01835
type: Species
name: maltotriose
initial amount: NaN
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
constant: false

metaM mgacpail hs r
type: Species
initial amount: NaN
notes: FORMULA: C37H68NO19PFULLRCO2FULLR2CO2 CHARGE: 0
constant: false
initial concentration: 1.0
is: SBO:0000247
is: C00249
boundary condition: false
name: mannosyl-glucosaminyl-acylphosphatidylinositiol (H2)
is: HMDB00220
has only substance units: false
is: CHEBI:7896

metaR r2443
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
fast: false
reversible: false
type: Reaction
kinetic law: MODEL1310110026#
is: SBO:0000185
reactant: MODEL1310110026#
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
product: MODEL1310110026#

metaR PPA
kinetic law: MODEL1310110026#
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110026#
name: inorganic diphosphatase
type: Reaction
modifier: MODEL1310110026#
fast: false
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.6.1.1
reversible: false
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:

metaR GGT6
product: MODEL1310110026#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
fast: false
name: Gamma-glutamyltransferase
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
kinetic law: MODEL1310110026#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_69e11190_d660_4a4c_a1d2_ec627b250899
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: PDE5A
is encoded by: hsa:8654
type: Species

metaR FACOAL140i
product: MODEL1310110026#
name: fatty-acid--CoA ligase (tetradecanoate)
is: SBO:0000176
notes: GENE_ASSOCIATION: (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:JLR
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
type: Reaction
reversible: false
fast: false
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269

metaM dhcholestanate r
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
has only substance units: false
is: HMDB00359
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:16577
is: SBO:0000247
constant: false
initial concentration: 1.0

metaR PSFLIPm
fast: false
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.6.3.1
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: false
is described by: ECO:0000269
name: phosphatidylserine flippase
modifier: MODEL1310110026#
product: MODEL1310110026#
type: Reaction

metaR DGSNt
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110026#
reactant: MODEL1310110026#
name: deoyguanosine transport via diffusion
is: SBO:0000185
kinetic law: MODEL1310110026#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:

metaR HIBDm
type: Reaction
reactant: MODEL1310110026#
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
is described by: ECO:0000269
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.1.1.31
reversible: true
fast: false
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
is: SBO:0000176

metaM mem2emgacpail prot hs r
is: CHEBI:58190
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: ({[(mannosyl),(phosphoethanolaminyl)]-dimannosyl},{phosphoethanolaminyl})-mannosyl-glucosaminyl-acylphosphatidylinositol-Protein (M4B)
has only substance units: false
notes: FORMULA: C59H110N3O40P3FULLRCO2FULLR2CO2X CHARGE: 0
constant: false
initial amount: NaN
type: Species
is: HMDB00224

metaM HC02205 e
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:28099
initial concentration: 1.0
name: prostaglandin-b2

http://identifiers.org/biomodels.db/MODEL1310110026#_c3600fa4_b495_4fc9_8409_e7d3328853ad
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AI285872
boundary condition: true
type: Species
constant: false
initial concentration: NaN
has only substance units: false
name: _AI285872_1_c

http://identifiers.org/biomodels.db/MODEL1310110026#_9766c845_74e1_467b_b0d0_c0a1741fe8db
is: P04075
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
constant: false
name: ALDOA
is encoded by: hsa:226

http://identifiers.org/biomodels.db/MODEL1310110026#_0af32dbc_b66a_4caf_ac3e_831b011df67c
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:4832
type: Species
is: Q13232
constant: false
name: NME3

http://identifiers.org/biomodels.db/MODEL1310110026#_f8be11ef_0055_4b09_bd16_fb9ec8369102
type: Species
is: SBO:0000252
is encoded by: hsa:65263
constant: false
boundary condition: true
is: Q53H96
initial concentration: NaN
name: PYCRL
initial amount: NaN
has only substance units: false

metaR PDX5PO
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110026#
modifier: MODEL1310110026#
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:15182361,PMID:6380540 NOTES:NCD
name: pyridoxine 5'-phosphate oxidase
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.4.3.5
kinetic law: MODEL1310110026#

metaM CE5162 r
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,18-19,26-28,32-34,38,49-50H,4-10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5162
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
boundary condition: false
name: trans,cis-2,9-octadecadienoyl-CoA
is: CHEBI:57923

http://identifiers.org/biomodels.db/MODEL1310110026#_e56b8d48_a7cf_477b_b92f_a98df9ad655e
is: P00441
boundary condition: true
has only substance units: false
is encoded by: hsa:6647
constant: false
type: Species
name: SOD1
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR AG13T2g
reversible: false
reactant: MODEL1310110026#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
kinetic law: MODEL1310110026#
is: SBO:0000176
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction
product: MODEL1310110026#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus

metaR GLCt1r
modifier: MODEL1310110026#
reactant: MODEL1310110026#
type: Reaction
reversible: true
fast: false
product: MODEL1310110026#
kinetic law: MODEL1310110026#
is: SBO:0000185
name: glucose transport (uniport)
notes: GENE_ASSOCIATION: (66035.1) or (6517.1) or (56606.1) or (154091.1) or (6513.1) or (11182.1) or (29988.1) or (6514.1) or (155184.1) or (56606.2) or (144195.1) or (6515.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860667,PMID:10860996,PMID:10970791,PMID:11247674,PMID:11583593,PMID:11592815,PMID:11780753,PMID:11832379,PMID:11882499,PMID:12135767,PMID:12483288,PMID:12504846,PMID:12750891,PMID:12914765,PMID:14739288,PMID:15033637,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:
is described by: ECO:0000269

metaR C101CPT1
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decenoylcarnitine
type: Reaction

metaM udpgal c
is: SBO:0000247
constant: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
initial concentration: 1.0
type: Species
is: HMDB00302
name: UDP-D-galactose(2-)
is: CHEBI:58439
boundary condition: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_3199a161_407d_4911_b31e_e7ab05345ad6
name: PIK3CA:PIK3R2
is encoded by: hsa:5290
initial concentration: NaN
has part: O00459
type: Species
has only substance units: false
initial amount: NaN
has part: P42336
constant: false
is encoded by: hsa:5296
boundary condition: true
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110026#_db57a916_be1f_4410_8f08_34cb3fef6061
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: _2544_1_c
type: Species
is encoded by: hsa:2544
boundary condition: true
constant: false

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

metaM gln L m
is: CHEBI:18050
is: SBO:0000247
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
initial amount: NaN
is: HMDB00641
initial concentration: 1.0
boundary condition: false
name: L-glutamine
constant: false
has only substance units: false
type: Species

metaM HC02204 e
is: SBO:0000247
is: CHEBI:27624
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
constant: false
initial amount: NaN
initial concentration: 1.0
name: prostaglandin-b1
boundary condition: false
has only substance units: false
type: Species

metaR r1492
reversible: false
name: Utilized transport
fast: false
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
product: MODEL1310110026#
is: SBO:0000185
type: Reaction

metaM pyr m
type: Species
is: CHEBI:15361
is: HMDB00243
name: pyruvate
initial concentration: 1.0
boundary condition: false
constant: false
is: C00022
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: http://identifiers.org/pubchem.compound/3324

metaR NACHEXA22ly
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase A, lysosomal
fast: false
modifier: MODEL1310110026#
is: SBO:0000176
reactant: MODEL1310110026#
reversible: false
product: MODEL1310110026#
kinetic law: MODEL1310110026#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR GULNter
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: L-gulonate endoplasmic reticular export
kinetic law: MODEL1310110026#
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110026#
reversible: false
reactant: MODEL1310110026#

metaM fol e
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C19H18N7O6 CHARGE: -1
initial concentration: 1.0
boundary condition: false
is: HMDB00121
constant: false
name: Folate

metaR C226CRNt
reactant: MODEL1310110026#
product: MODEL1310110026#
kinetic law: MODEL1310110026#
name: C226 transport into the mitochondria
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
fast: false
type: Reaction
reversible: false

metaM ocdcea e
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C18H33O2 CHARGE: -1
is: CHEBI:0
is: C00712
name: octadecenoate (n-C18:1)
is: HMDB00207
constant: false
type: Species
initial amount: NaN

metaR UROLACer
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
product: MODEL1310110026#
name: uronolactonase, endoplasmic reticulum
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.19 Confidence Level: 1 AUTHORS: PMID:13587494 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
fast: false
type: Reaction

metaR ACGALtly
name: N-acetyl-galactosamine lysosomal efflux
type: Reaction
kinetic law: MODEL1310110026#
reversible: false
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
fast: false
product: MODEL1310110026#
is described by: ECO:0000000
is: SBO:0000185

metaR GCC2am
is: SBO:0000176
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110026#
name: glycine-cleavage complex (lipoamide), mitochondrial
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/1.4.4.2
is version of: http://identifiers.org/ec-code/2.1.2.10
fast: false
product: MODEL1310110026#
reversible: true
kinetic law: MODEL1310110026#

metaM core6 l
is: CHEBI:12936
constant: false
notes: FORMULA: C16H27N2O10X CHARGE: 0
type: Species
is: SBO:0000247
initial amount: NaN
name: Core 6
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB00143

http://identifiers.org/biomodels.db/MODEL1310110026#_7f3157a0_3c68_4f46_91c1_054d6b6379b3
initial amount: NaN
constant: false
is encoded by: hsa:11332
is: O00154
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: ACOT7
type: Species

metaM fol m
name: Folate
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
is: HMDB00121
notes: FORMULA: C19H18N7O6 CHARGE: -1 INCHI: InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00396 EHMN_ABBREVIATION: C00504
is: CHEBI:27470
initial concentration: 1.0

metaR UPP3S
notes: GENE_ASSOCIATION: (7390.1) SUBSYSTEM: Heme synthesis EC Number: 4.2.1.75 Confidence Level: 0 AUTHORS: PMID:3174619 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
name: uroporphyrinogen-III synthase
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.75
is: SBO:0000176
modifier: MODEL1310110026#
type: Reaction
product: MODEL1310110026#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110026#_8aaaafe5_033b_48fc_b617_fdc24b3b2410
has only substance units: false
is encoded by: hsa:5288
initial amount: NaN
constant: false
is: O75747
name: PIK3C2G
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species

metaM HC02205 c
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:28099
name: prostaglandin-b2
type: Species
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954

http://identifiers.org/biomodels.db/MODEL1310110026#_e5f22b17_5976_47ad_b525_6f105655caf8
initial concentration: NaN
boundary condition: true
is: Q7GXZ8
name: COX2
has only substance units: false
type: Species
constant: false
is encoded by: hsa:4513
is: SBO:0000252
initial amount: NaN

metaM glutcoa c
has only substance units: false
is: HMDB01339
constant: false
initial amount: NaN
name: glutaryl-CoA(5-)
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1
is: SBO:0000247

metaR CRVNCtr
reversible: true
is described by: ECO:0000000
name: fatty acid transport via diffusion
product: MODEL1310110026#
is: SBO:0000185
kinetic law: MODEL1310110026#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110026#

metaM ksi deg24 l
is: CHEBI:12936
has only substance units: false
constant: false
type: Species
is: SBO:0000247
is: HMDB00143
boundary condition: false
initial amount: NaN
notes: FORMULA: C118H191N8O101S5 CHARGE: -5
initial concentration: 1.0
name: keratan sulfate I, degradation product 24

metaM 4hpro LT m
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:18095
name: trans-4-hydroxy-L-proline
is: HMDB00725
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_e80003ee_27e4_47e5_95d6_a39d6105b002
is encoded by: hsa:5096
boundary condition: true
constant: false
is encoded by: hsa:5095
has part: P05166
has only substance units: false
has part: C9JPQ8
initial concentration: NaN
is: SBO:0000297
name: PCCA:PCCB
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_1ab67b0d_0201_4db2_80e8_b3a99d6f8dfb
is: H7C5B8
initial amount: NaN
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4708
name: NDUFB2
has only substance units: false

metaR ACALDtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:9028626 NOTES:NCD
reactant: MODEL1310110026#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
name: acetaldehyde mitochondrial diffusion
fast: false
product: MODEL1310110026#
kinetic law: MODEL1310110026#
type: Reaction

metaR MCLACCYSR
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:6945862 NOTES:MM
type: Reaction
reactant: MODEL1310110026#
fast: false
is: SBO:0000176
product: MODEL1310110026#
is described by: ECO:0000000
name: 3-mercaptolactate:cysteine reductase
kinetic law: MODEL1310110026#

metaM ser D e
initial amount: NaN
name: D-serine
constant: false
is: CHEBI:16523
has only substance units: false
boundary condition: false
is: HMDB03406
is: SBO:0000247
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_3c320a03_c5fb_441b_9a44_0b622a5d2587
is: SBO:0000252
name: DPM2
boundary condition: true
type: Species
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:8818
initial concentration: NaN
is: O94777

http://identifiers.org/biomodels.db/MODEL1310110026#_53131ecf_09d9_4ae0_856c_8e70a3777eb5
initial amount: NaN
is encoded by: hsa:641371
has only substance units: false
constant: false
type: Species
is: E9KL42
initial concentration: NaN
name: ACOT1
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110026#_e89663a0_2234_4d9f_bb55_159a0b393ce6
is: E7ET32
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:2592
name: GALT
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_02d22130_e6c8_416d_b3cb_4b6b2da35613
type: Species
is: SBO:0000252
is: E9PB82
is encoded by: hsa:3295
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
name: HSD17B4
has only substance units: false

metaR Ser Thrtg
reactant: MODEL1310110026#
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
product: MODEL1310110026#
reversible: true
fast: false
kinetic law: MODEL1310110026#
name: Ser/Thr transport (from golgi to lysosome)

http://identifiers.org/biomodels.db/MODEL1310110026#_0809ecbb_4c07_4e16_988b_d0048dedad1f
constant: false
is: SBO:0000252
initial concentration: NaN
name: GGT7
is: A0PJJ9
is encoded by: hsa:2686
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_8c3f32fe_63c4_4f8b_aba6_c17d07da6616
is: O75747
name: PIK3C2G
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:5288
has only substance units: false

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

metaR r0531
reversible: true
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.1.1.34
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:9923963 NOTES:
product: MODEL1310110026#
is described by: ECO:0000000
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
name: dUTP:cytidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
type: Reaction
is: SBO:0000176
fast: false

metaR AKR1C42
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/1.1.1.225
product: MODEL1310110026#
reactant: MODEL1310110026#
is: SBO:0000176
modifier: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
fast: false
reversible: false
is described by: ECO:0000269
name: aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)

http://identifiers.org/biomodels.db/MODEL1310110026#_0ffe9cb8_01d8_494d_9847_ff31341262e3
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:4715
initial concentration: NaN
name: NDUFB9
constant: false
is: SBO:0000252
type: Species
is: Q9Y6M9

metaM gal e
name: D-Galactose
is: CHEBI:0
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB00143
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0
constant: false
has only substance units: false
is: C00124

metaM HC00250 c
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:29919
type: Species
initial amount: NaN
has only substance units: false
name: hydrosulfide

http://identifiers.org/biomodels.db/MODEL1310110026#_d905fd39_c0c9_476f_bb1f_e0a7654e9e0f
boundary condition: true
is encoded by: hsa:4726
is: SBO:0000252
type: Species
is: Q6IBC4
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: NDUFS6
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_1f5e9375_00a0_4438_8e9b_f3b9de6f94e7
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: PMVK
is encoded by: hsa:10654
constant: false
initial concentration: NaN
is: Q6FGV9
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_49a562e2_7ec8_4ff8_9c93_9f7ca65c23d3
is encoded by: hsa:57786
type: Species
initial amount: NaN
name: RBAK
constant: false
boundary condition: true
initial concentration: NaN
is: Q9NYW8
has only substance units: false
is: SBO:0000252

metaM ppcoa m
name: Propanoyl-CoA
constant: false
is: CHEBI:57392
boundary condition: false
is: HMDB01275
is: SBO:0000247
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: C00100
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaM digalside hs g
is: C06126
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C06126
has only substance units: false
type: Species
is: http://identifiers.org/pubchem.compound/8383
boundary condition: false
name: Digalactosylceramide

metaR PRPPS
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:
name: phosphoribosylpyrophosphate synthetase
modifier: MODEL1310110026#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.6.1
kinetic law: MODEL1310110026#
reversible: true
reactant: MODEL1310110026#
product: MODEL1310110026#
is described by: ECO:0000000
fast: false
type: Reaction

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

metaM ocdcea c
name: octadecenoate (n-C18:1)
is: HMDB00207
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C18H33O2 CHARGE: -1
is: CHEBI:0
type: Species
initial amount: NaN
is: C00712

metaR ALAGLYexR
product: MODEL1310110026#
is: SBO:0000185
fast: false
name: L-alanine/glycine reversible exchange
is described by: ECO:0000304
reactant: MODEL1310110026#
reversible: true
type: Reaction
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110026#

metaR r2331
product: MODEL1310110026#
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110026#_e35a7af4_4753_4f91_8ed9_59042c65ed36
name: ATP1B3
boundary condition: true
is encoded by: hsa:483
type: Species
is: SBO:0000252
constant: false
is: P54709
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaR VALLAT1tc
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Valine by LAT1 in association with 4F2hc, across the apical surface of the memebranes.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_b84c6799_f844_4c1b_af1a_0a4e6a6d69d0
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
is: P49753
constant: false
name: ACOT2
is encoded by: hsa:10965

http://identifiers.org/biomodels.db/MODEL1310110026#_cfffa7ce_2dd6_41f1_b802_55ecd687fc02
type: Species
has only substance units: false
is encoded by: hsa:570
constant: false
initial amount: NaN
boundary condition: true
is: Q14032
name: BAAT
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_5db3ad3f_9b33_4e14_b601_cf76e7105200
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
type: Species
is encoded by: hsa:4907
is: SBO:0000252
has only substance units: false
is: P21589
name: NT5E

metaR r2109
is: SBO:0000185
product: MODEL1310110026#
reactant: MODEL1310110026#
reversible: true
is described by: ECO:0000000
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM gln L c
is: SBO:0000247
has only substance units: false
name: L-glutamine
type: Species
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: HMDB00641
is: CHEBI:18050

http://identifiers.org/biomodels.db/MODEL1310110026#_6f8019f4_bab3_4872_b317_14f7523774c2
name: PYCR1
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: A6NFM2
is encoded by: hsa:5831
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_960e52e8_3368_4354_adc7_23fa8b5b919e
has only substance units: false
is: SBO:0000252
name: AK1
is: P00568
constant: false
is encoded by: hsa:203
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true

metaR r0829
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
fast: false
reversible: true
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/4.1.1.37
is described by: ECO:0000000
reactant: MODEL1310110026#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_2f6ac8c6_b953_4957_9018_dbf7814133cd
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:5151
constant: false
initial concentration: NaN
name: PDE8A
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_6fa0e86a_0070_44b6_b476_9bed6a829b42
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:1103
boundary condition: true
is: Q6LEN5
is: SBO:0000252
constant: false
name: CHAT
initial concentration: NaN

metaR r2330
reactant: MODEL1310110026#
fast: false
is described by: ECO:0000000
product: MODEL1310110026#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110026#
is: SBO:0000185
reversible: true

metaM ethamp r
constant: false
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00224
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
is: SBO:0000247
name: O-phosphonatoethanaminium(1-)
is: CHEBI:58190

metaR DMHPTCRNte
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
is: SBO:0000185
name: 2,6 dimethylheptanoyl carnitine transport
type: Reaction
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:unknown mechanism for transport -see PMID 9299016, identifies 2,6-dimethylheptanoyl carnitine in the urine! NJ
fast: false
reversible: true
is described by: ECO:0000000

metaR r0974
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110026#
reversible: true
product: MODEL1310110026#
fast: false
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
is: SBO:0000185
name: Active transport

http://identifiers.org/biomodels.db/MODEL1310110026#_fe5864a4_15eb_41b2_8f54_933ab4f523c9
name: CHAT
is: SBO:0000252
initial amount: NaN
is: Q6LEN5
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:1103
boundary condition: true
has only substance units: false

metaM core6 g
name: Core 6
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:16478
notes: FORMULA: C16H27N2O10X CHARGE: 0

metaR r2108
type: Reaction
modifier: MODEL1310110026#
reactant: MODEL1310110026#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_fe38b1df_d82c_4bec_9ce6_f6549e86020a
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:80201
boundary condition: true
type: Species
initial amount: NaN
name: HKDC1
is: B3KT70
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_c0b03ff3_1144_43bc_a8ae_7cf6eda3f2bb
is encoded by: hsa:84129
initial amount: NaN
constant: false
boundary condition: true
is: Q709F0
initial concentration: NaN
type: Species
name: ACAD11
is: SBO:0000252
has only substance units: false

metaM btcoa m
name: Butanoyl-CoA
is: SBO:0000247
type: Species
constant: false
is: CHEBI:57371
boundary condition: false
is: HMDB01088
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
initial concentration: 1.0
is: C00136
has only substance units: false
initial amount: NaN

metaR r2107
product: MODEL1310110026#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110026#
is: SBO:0000185
kinetic law: MODEL1310110026#
is described by: ECO:0000000
reactant: MODEL1310110026#
fast: false

metaR EX HC02207 LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-c2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_f80230ae_a237_4f5a_926a_57fee3d36d50
constant: false
is encoded by: hsa:AI697028
name: _AI697028_1_m
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_481a35e1_3e4c_4ec8_a7c4_fc210338ec1c
constant: false
is encoded by: hsa:29968
is: SBO:0000252
boundary condition: true
has only substance units: false
is: Q9Y617
type: Species
initial amount: NaN
initial concentration: NaN
name: PSAT1

metaM lnlc c
is: CHEBI:30245
initial concentration: 1.0
name: linoleate
constant: false
boundary condition: false
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
is: HMDB00673
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_ac722a1e_5004_4b0d_9d24_a83097c019ba
constant: false
initial concentration: NaN
is: SBO:0000252
name: ATP5E
type: Species
boundary condition: true
is encoded by: hsa:514
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_e6b7f0b5_59ff_4125_bc06_1d22b8fcafa8
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:7296
constant: false
name: TXNRD1
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110026#_0e89258f_8bb1_48b7_8f4d_6a32e16fd152
is: P16442
has only substance units: false
name: ABO
constant: false
is encoded by: hsa:28
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species

metaR ACNAMlt
reversible: true
name: N-acetylneuraminate transport into lysososme
kinetic law: MODEL1310110026#
is: SBO:0000185
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ
fast: false
product: MODEL1310110026#
is described by: ECO:0000269
reactant: MODEL1310110026#
type: Reaction
modifier: MODEL1310110026#

metaR EX glygn5 LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycogen, structure 5 (glycogenin-2[1,4-Glc])
type: Reaction

metaR PRAGSr
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.1.2.2
kinetic law: MODEL1310110026#
name: phosphoribosylglycinamide synthase
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
fast: false
product: MODEL1310110026#
reactant: MODEL1310110026#

metaM dhcholestanate x
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:16577
is: HMDB00359
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554

metaM gln L e
has only substance units: false
name: L-glutamine
constant: false
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: HMDB00641
is: CHEBI:18050
is: SBO:0000247

metaR r2106
is: SBO:0000185
kinetic law: MODEL1310110026#
reversible: true
type: Reaction
reactant: MODEL1310110026#
modifier: MODEL1310110026#
fast: false
product: MODEL1310110026#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM ascb L e
is: HMDB00044
initial amount: NaN
is: CHEBI:38290
has only substance units: false
type: Species
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
name: L-ascorbate

metaM galside hs l
initial concentration: 1.0
is: CHEBI:12947
constant: false
name: D-galactosyl-N-acylsphingosine
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaM 3php c
is: CHEBI:18110
name: 3-phosphonatooxypyruvate(3-)
notes: FORMULA: C3H2O7P CHARGE: -3 INCHI: InChI=1S/C3H5O7P/c4-2(3(5)6)1-10-11(7,8)9/h1H2,(H,5,6)(H2,7,8,9)/p-3 HEPATONET_1.0_ABBREVIATION: HC01082 EHMN_ABBREVIATION: C03232
constant: false
is: HMDB01024
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_57e13876_4af2_403f_9d0a_57654d19f9c6
has part: P48201
is encoded by: hsa:518
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000297
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
constant: false
has only substance units: false

metaM citr L m
constant: false
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
initial concentration: 1.0
name: L-citrulline
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:16349
is: HMDB00904
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_aa6ec863_3928_4467_9a2e_38cf420571f8
initial amount: NaN
is encoded by: hsa:4697
is: O00483
name: NDUFA4
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false

metaM pail5p hs c
is: SBO:0000247
has only substance units: false
type: Species
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
initial amount: NaN
constant: false
is: CHEBI:57795
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
boundary condition: false
initial concentration: 1.0

metaR r1493
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:15845416 NOTES:
reversible: false
product: MODEL1310110026#
is: SBO:0000185
reactant: MODEL1310110026#
is described by: ECO:0000000
name: Utilized transport
fast: false
type: Reaction
kinetic law: MODEL1310110026#

metaM ksii core4 pre6 g
is: CHEBI:28067
type: Species
name: keratan sulfate II biosynthesis, precursor 6
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C69H111N6O51SX CHARGE: -2

metaR RE0383C
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.2
type: Reaction
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
product: MODEL1310110026#
is: SBO:0000176
reversible: true
name: RE0383
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#

metaR r2335
is: SBO:0000185
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110026#
reactant: MODEL1310110026#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110026#

metaR r1380
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
type: Reaction
product: MODEL1310110026#
is: SBO:0000176
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
is described by: ECO:0000000
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110026#_6b6d344a_686b_4688_b8e9_3a58cad3bbf9
boundary condition: true
name: SLC4A5
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:57835
is: SBO:0000252
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_2c5e0478_cbef_49fd_b422_2a9eaa568a67
is encoded by: hsa:1351
has only substance units: false
name: COX8A
boundary condition: true
is: SBO:0000252
is: Q53XN1
initial amount: NaN
type: Species
initial concentration: NaN
constant: false

metaM galside hs g
initial concentration: 1.0
name: D-galactosyl-N-acylsphingosine
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
has only substance units: false
is: CHEBI:12947
constant: false

metaR r0753
is described by: ECO:0000000
modifier: MODEL1310110026#
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:
kinetic law: MODEL1310110026#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000176
fast: false
reversible: true
product: MODEL1310110026#

metaM lnlc e
boundary condition: false
has only substance units: false
constant: false
is: HMDB00673
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
name: linoleate
is: CHEBI:30245

metaR DM T antigen g
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: DM T antigen(g)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_647049aa_cde7_406d_975d_ce93a8badc7b
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
name: INPP5E
initial concentration: NaN
is: Q9NRR6
constant: false
is encoded by: hsa:56623

metaM dnad c
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
type: Species
is: CHEBI:18304
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB01179
is: C00857
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: Deamino-NAD+

http://identifiers.org/biomodels.db/MODEL1310110026#_33b0ac85_60ca_4364_b8d8_94078d21a8dc
is: SBO:0000252
is encoded by: hsa:5464
constant: false
name: PPA1
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q15181
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_a49b5522_e146_4534_acd3_a6533d2b091e
is encoded by: hsa:1329
is: SBO:0000252
name: COX5B
initial amount: NaN
is: Q53YB7
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
constant: false

metaR r2334
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: true
fast: false
product: MODEL1310110026#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM ahdt e
constant: false
has only substance units: false
name: 7,8-dihydroneopterin 3'-triphosphate(4-)
initial concentration: 1.0
notes: FORMULA: C9H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C9H16N5O13P3/c10-9-13-7-5(8(17)14-9)12-3(1-11-7)6(16)4(15)2-25-29(21,22)27-30(23,24)26-28(18,19)20/h4,6,15-16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H4,10,11,13,14,17)/p-4/t4-,6+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01367 EHMN_ABBREVIATION: C04895
initial amount: NaN
is: CHEBI:58462
is: SBO:0000247
boundary condition: false
is: HMDB00980
type: Species

metaM ppcoa c
initial amount: NaN
constant: false
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
name: Propanoyl-CoA
has only substance units: false
is: C00100
boundary condition: false
type: Species
is: HMDB01275
is: CHEBI:57392
initial concentration: 1.0
is: SBO:0000247

metaR r1381
fast: false
product: MODEL1310110026#
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
kinetic law: MODEL1310110026#
reversible: true
reactant: MODEL1310110026#
is described by: ECO:0000000

metaM CE2420 m
is: HMDB11123
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
constant: false
initial concentration: 1.0
is: CHEBI:28387
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA

metaR ICDHyrm
is version of: http://identifiers.org/ec-code/1.1.1.42
is: SBO:0000176
reversible: true
type: Reaction
fast: false
is described by: ECO:0000269
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
product: MODEL1310110026#
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
name: Isocitrate dehydrogenase (NADP+)

metaM hyptaur c
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
initial concentration: 1.0
is: HMDB00965
name: Hypotaurine
is: CHEBI:16668
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_b469db15_33cb_4f63_b678_2c02279ef7dd
type: Species
is: SBO:0000252
is encoded by: hsa:411
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: ARSB
is: P15848
has only substance units: false

metaR r0752
fast: false
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:
type: Reaction
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
is: SBO:0000176
reversible: true
modifier: MODEL1310110026#
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16

metaM ascb L c
name: L-ascorbate
initial concentration: 1.0
is: HMDB00044
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:38290
constant: false
has only substance units: false
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074

metaR DNDPt28m
type: Reaction
kinetic law: MODEL1310110026#
is: SBO:0000185
reversible: false
reactant: MODEL1310110026#
name: dCDP transport via dGDP antiport
modifier: MODEL1310110026#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110026#
fast: false

metaR r0755
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
fast: false
reversible: true
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (37.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:1898068 NOTES:
is: SBO:0000176
modifier: MODEL1310110026#
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
is described by: ECO:0000000
product: MODEL1310110026#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_3c7adc6a_3f21_4be0_908b_c714fb7d3ffd
name: CYP7A1
initial concentration: NaN
is encoded by: hsa:1581
has only substance units: false
is: P22680
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110026#_bbd0d1dc_c3ef_4647_8475_738956557970
is encoded by: hsa:AA788780
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
has only substance units: false
name: _AA788780_1_c
boundary condition: true
is: SBO:0000252

metaR RE2660C
reactant: MODEL1310110026#
name: RE2660
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110026#
product: MODEL1310110026#
is: SBO:0000176
type: Reaction

metaR r2333
kinetic law: MODEL1310110026#
is: SBO:0000185
reactant: MODEL1310110026#
is described by: ECO:0000000
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
reversible: true

metaM glutcoa m
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
constant: false
has only substance units: false
is: HMDB01339
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
name: glutaryl-CoA(5-)
is: CHEBI:57378
initial amount: NaN

metaM pyr x
type: Species
is: CHEBI:15361
boundary condition: false
is: HMDB00243
constant: false
is: http://identifiers.org/pubchem.compound/3324
initial concentration: 1.0
name: pyruvate
is: SBO:0000247
is: C00022
initial amount: NaN
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
has only substance units: false

metaM ru5p D c
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58121
is: SBO:0000247
name: D-ribulose 5-phosphate(2-)
is: HMDB00618
boundary condition: false
constant: false

metaM fadh2 c
initial concentration: 1.0
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:58307
boundary condition: false
name: FADH2(2-)
is: HMDB01197

http://identifiers.org/biomodels.db/MODEL1310110026#_bbf4e205_a9a9_4b87_ae3b_ff8148217480
initial amount: NaN
name: ACSL5
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:51703
boundary condition: true
is: Q9ULC5
constant: false
has only substance units: false

metaM pchol hs c
type: Species
constant: false
has only substance units: false
initial amount: NaN
name: Phosphatidylcholine
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16110
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false

metaR 4HPRO LTte
reactant: MODEL1310110026#
product: MODEL1310110026#
reversible: true
kinetic law: MODEL1310110026#
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of trans-4-hydroxy-L-proline

http://identifiers.org/biomodels.db/MODEL1310110026#_b0173a02_8ce6_4e5d_8221_44718279a85d
boundary condition: true
is encoded by: hsa:6513
has only substance units: false
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is: P11166
name: SLC2A1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110026#_ce4577dc_95ed_4cd6_b687_bab7841ac879
initial amount: NaN
constant: false
has only substance units: false
name: TSTA3
is: SBO:0000252
type: Species
is encoded by: hsa:7264
initial concentration: NaN
boundary condition: true
is: Q13630

metaR DGULND
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
fast: false
product: MODEL1310110026#
kinetic law: MODEL1310110026#
is: SBO:0000176
reactant: MODEL1310110026#
name: dehydro-L-gulonate decarboxylase
is described by: ECO:0000000
type: Reaction
reversible: true

metaR r1705
reactant: MODEL1310110026#
modifier: MODEL1310110026#
product: MODEL1310110026#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
name: Y+LAT2 Utilized transport
fast: false
kinetic law: MODEL1310110026#

metaR AG13T16g
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110026#
type: Reaction
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10678.2) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110026#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110026#
is: SBO:0000176
product: MODEL1310110026#
fast: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus

metaR r2332
is described by: ECO:0000000
kinetic law: MODEL1310110026#
reversible: true
type: Reaction
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110026#
reactant: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110026#_786523d1_a2af_46ca_9fd9_f68211fde53a
is: P48735
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3418
constant: false
name: IDH2
initial concentration: NaN
type: Species
boundary condition: true

metaM HC00822 e
has only substance units: false
constant: false
notes: FORMULA: C16H28N2O11 CHARGE: 0 INCHI: InChI=1S/C16H28N2O11/c1-5(21)17-9-13(25)14(8(4-20)27-15(9)26)29-16-10(18-6(2)22)12(24)11(23)7(3-19)28-16/h7-16,19-20,23-26H,3-4H2,1-2H3,(H,17,21)(H,18,22)/t7-,8-,9-,10-,11-,12-,13-,14-,15?,16+/m1/s1 EHMN_ABBREVIATION: C01674
boundary condition: false
is: CHEBI:28681
initial concentration: 1.0
is: SBO:0000247
name: Chitobiose
type: Species
initial amount: NaN

metaM 3aib D m
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: C03265
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
type: Species
is: HMDB02299
name: D-3-Amino-isobutanoate
initial amount: NaN
constant: false

metaM 2dr5p c
initial concentration: 1.0
name: 2-deoxy-D-ribose 5-phosphate(2-)
is: HMDB01031
constant: false
is: SBO:0000247
is: CHEBI:57651
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673

metaR F1Atg
product: MODEL1310110026#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
name: F1alpha transport (from golgi to lysosome)
type: Reaction
is: SBO:0000185
reactant: MODEL1310110026#
fast: false

metaR r0754
product: MODEL1310110026#
type: Reaction
reactant: MODEL1310110026#
is: SBO:0000176
reversible: true
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
kinetic law: MODEL1310110026#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110026#
fast: false

metaM ksii core2 pre6 g
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C61H98N5O46SX CHARGE: -2
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:28067
name: keratan sulfate II biosynthesis, precursor 6

metaR DOLPGT2 Uer
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
kinetic law: MODEL1310110026#
reversible: false
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (79053.1) or (79053.3) or (79053.2) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
is version of: http://identifiers.org/ec-code/2.4.1.265
is: SBO:0000176
product: MODEL1310110026#
fast: false
modifier: MODEL1310110026#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110026#_5d4c05d9_240e_4372_ba34_91620086b435
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:123041
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
name: SLC24A4

metaR r0310
product: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: false
reactant: MODEL1310110026#
name: Palmitoyl-CoA:oxygen 2-oxidoreductase Fatty acid metabolism EC:1.3.3.6 EC:1.3.99.3
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
is: SBO:0000176
is described by: ECO:0000000

metaR UMPK4n
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110026#
is described by: ECO:0000269
reactant: MODEL1310110026#
name: UMP kinase (GTP),nuclear
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110026#
type: Reaction
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110026#_4739a798_4206_4154_a3f5_0edfa942ec1a
is: SBO:0000252
name: SYNJ2
type: Species
constant: false
boundary condition: true
is: O15056
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:8871
has only substance units: false

metaR r2112
is: SBO:0000185
product: MODEL1310110026#
fast: false
type: Reaction
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR r2326
is described by: ECO:0000000
kinetic law: MODEL1310110026#
reversible: true
type: Reaction
reactant: MODEL1310110026#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
product: MODEL1310110026#
fast: false

metaM tmndnc c
is: SBO:0000247
notes: FORMULA: C20H29O2 CHARGE: -1 INCHI: InChI=1/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-
initial amount: NaN
is: HMDB01999
name: timnodonic acid C20:5, n-3
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/446284
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_208e8d40_ec8b_466b_9196_a1eba26f21fc
boundary condition: true
is: SBO:0000252
name: AK5
constant: false
initial concentration: NaN
is encoded by: hsa:26289
initial amount: NaN
has only substance units: false
type: Species
is: Q9Y6K8

metaR SCPx
type: Reaction
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways NJ
product: MODEL1310110026#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.176
kinetic law: MODEL1310110026#
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110026#
reactant: MODEL1310110026#
reversible: false
name: peroxisomal thiolase 2

metaR r1921
kinetic law: MODEL1310110026#
product: MODEL1310110026#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
modifier: MODEL1310110026#
is described by: ECO:0000000
fast: false
reversible: false

metaR NACHEXA9ly
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
product: MODEL1310110026#
name: beta-N-acetylhexosaminidase A, lysosomal
reversible: false
reactant: MODEL1310110026#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
fast: false
kinetic law: MODEL1310110026#

metaR RE2759X
is: SBO:0000176
reversible: true
name: RE2759
kinetic law: MODEL1310110026#
type: Reaction
fast: false
product: MODEL1310110026#
reactant: MODEL1310110026#
modifier: MODEL1310110026#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/5.1.99.4
notes: GENE_ASSOCIATION: (23600.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.1.99.4 Confidence Level: 0 AUTHORS: PMID:11060344,PMID:11060359 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110026#_bb80bd60_0fa3_4618_8130_d25b5a2ec2d0
type: Species
initial amount: NaN
name: ACP2
is encoded by: hsa:53
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is: E9PCI1

http://identifiers.org/biomodels.db/MODEL1310110026#_ffd45885_7a2e_43fd_85f4_c8c4dfed38c2
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
is: P23219
has only substance units: false
initial concentration: NaN
name: PTGS1
is encoded by: hsa:5742

http://identifiers.org/biomodels.db/MODEL1310110026#_f5de4375_d3af_49a8_bac2_c97253c45bbf
name: ATP5J2
type: Species
boundary condition: true
is encoded by: hsa:9551
initial concentration: NaN
constant: false
is: SBO:0000252
is: Q6IBB3
has only substance units: false
initial amount: NaN

metaM 4h2oglt m
name: 4-hydroxy-2-oxoglutarate(2-)
constant: false
is: HMDB02070
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C5H4O6 CHARGE: -2 INCHI: InChI=1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)/p-2
is: CHEBI:17742

metaM HC02203 e
is: CHEBI:27820
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
name: prostaglandin-a2

metaR PE HSter
reactant: MODEL1310110026#
name: phosphatidylethanolamine scramblase
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110026#
is described by: ECO:0000000
product: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:

metaM galside hs c
initial amount: NaN
constant: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:12947
name: D-galactosyl-N-acylsphingosine
type: Species

metaM pchol hs e
initial concentration: 1.0
is: CHEBI:16110
name: Phosphatidylcholine
is: SBO:0000247
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
type: Species
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN

metaR r0311
product: MODEL1310110026#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.9
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110026#
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
reactant: MODEL1310110026#
fast: false
type: Reaction
kinetic law: MODEL1310110026#
is: SBO:0000176
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reversible: false

metaR r2327
product: MODEL1310110026#
fast: false
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
reversible: true
is: SBO:0000185
type: Reaction

metaM tdcrn e
type: Species
notes: FORMULA: C21H41NO4 CHARGE: 0
name: myristoyl carnitine
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB05066
initial concentration: 1.0

metaR r2113
reversible: true
fast: false
product: MODEL1310110026#
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110026#

metaM dcsptn1 c
has only substance units: false
constant: false
type: Species
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5282848
boundary condition: false
name: docosa-4,7,10,13,16-pentaenoic acid
is: HMDB13123
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-

http://identifiers.org/biomodels.db/MODEL1310110026#_1ce6223b_e275_494a_b2fa_a1a06bc05096
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:10449
is: P42765
name: ACAA2
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_b581ab60_4c70_4616_ab8b_8328def171f4
type: Species
boundary condition: true
name: NDUFB2
initial concentration: NaN
is: H7C5B8
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:4708

metaM ru5p D r
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB00618
is: CHEBI:58121
has only substance units: false
boundary condition: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
constant: false
initial amount: NaN
name: D-ribulose 5-phosphate(2-)

http://identifiers.org/biomodels.db/MODEL1310110026#_2418eb1c_caf5_4d05_8838_411ef65cfc9e
constant: false
is encoded by: hsa:644
type: Species
boundary condition: true
name: BLVRA
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: P53004
initial amount: NaN

metaR GLYt7 211 r
kinetic law: MODEL1310110026#
type: Reaction
reversible: true
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
modifier: MODEL1310110026#
fast: false
name: glycine reversible transport via sodium and chloride symport (2:1:1)
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_53d7dde9_8fc2_4960_914c_492dab710a86
constant: false
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
is: Q308M7
initial amount: NaN
name: ENPP3
initial concentration: NaN
is encoded by: hsa:5169

http://identifiers.org/biomodels.db/MODEL1310110026#_18e29781_9fb3_4b09_9a00_cc25c2d18d03
initial amount: NaN
constant: false
is encoded by: hsa:23428
name: SLC7A8
is: Q9UHI5
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true

metaR RE1523M
is: SBO:0000176
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110026#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110026#
name: RE1523

http://identifiers.org/biomodels.db/MODEL1310110026#_42ec3de5_9624_4ca5_b684_366449e56704
is: C9JV30
is encoded by: hsa:3614
name: IMPDH1
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
type: Species

metaR r2324
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
reactant: MODEL1310110026#
is: SBO:0000185
product: MODEL1310110026#
kinetic law: MODEL1310110026#
fast: false

metaR r2110
is described by: ECO:0000000
reversible: true
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110026#
is: SBO:0000185
modifier: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110026#_697c32c8_ca60_4497_ba42_1003c549e091
is encoded by: hsa:5051
is: Q99487
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
name: PAFAH2

metaM g2m8mpdol U r
constant: false
boundary condition: false
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: SBO:0000247
is: CHEBI:59093
type: Species
has only substance units: false
notes: FORMULA: C1845H3040N20O720P20 CHARGE: -20
initial amount: NaN
initial concentration: 1.0

metaM glyc3p c
is: C00093
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
name: Glycerol 3-phosphate
is: CHEBI:57597
constant: false
is: SBO:0000247
is: HMDB00126
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
initial amount: NaN

metaR HDCAtr
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110026#
is: SBO:0000185
name: fatty acid transport via diffusion
reactant: MODEL1310110026#
product: MODEL1310110026#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110026#_87d7d565_cd6d_4d45_a26a_3b57fa0206aa
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:3163
initial concentration: NaN
name: HMOX2
is: P30519
constant: false
is: SBO:0000252

metaR R group phosphotase 1
product: MODEL1310110026#
is: SBO:0000176
name: R group phosphotase 1
reactant: MODEL1310110026#
fast: false
kinetic law: MODEL1310110026#
is described by: ECO:0000000
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:

metaR EX sucr LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sucrose exchange
type: Reaction

metaM retinal 11 cis c
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
name: 11-cis-retinal
initial concentration: 1.0
type: Species
is: HMDB02152
is: CHEBI:16066

metaM dhcholestancoa r
is: CHEBI:15494
boundary condition: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
initial amount: NaN
is: HMDB02159
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110026#_8206672e_9341_4ba2_9dde_dc1fecebaf6d
is encoded by: hsa:6241
constant: false
is: SBO:0000252
initial concentration: NaN
name: RRM2
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is: P31350

metaM 4nph e
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:57917
initial concentration: 1.0
is: HMDB01232
name: 4-nitrophenolate
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
constant: false

metaM dcsptn1 e
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
constant: false
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5282848
type: Species
is: HMDB13123
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: docosa-4,7,10,13,16-pentaenoic acid

metaR r2111
product: MODEL1310110026#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
modifier: MODEL1310110026#
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110026#_2910e1c3_d44d_4770_964f_1c081eaa4a61
initial concentration: NaN
name: ACSL1
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: P33121
is encoded by: hsa:2180
boundary condition: true
is: SBO:0000252

metaR r2325
is: SBO:0000185
type: Reaction
product: MODEL1310110026#
kinetic law: MODEL1310110026#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110026#
reversible: true
is described by: ECO:0000000

metaM HC02203 c
has only substance units: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
name: prostaglandin-a2
boundary condition: false
is: CHEBI:27820
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110026#_e4b2f5e5_db59_4edf_8dbb_0c8a01bd6a0b
constant: false
boundary condition: true
is encoded by: hsa:89874
type: Species
is: G3V4L5
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: SLC25A21

http://identifiers.org/biomodels.db/MODEL1310110026#_52adfa0c_0539_4b12_b10f_b7f95ac06f9f
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
name: ALDH3A2
type: Species
has only substance units: false
is encoded by: hsa:224
initial amount: NaN
is: P51648

metaM ksi pre2 g
type: Species
boundary condition: false
is: C00130
initial concentration: 1.0
initial amount: NaN
is: HMDB00175
is: CHEBI:58053
has only substance units: false
notes: FORMULA: C87H142N6O62X CHARGE: -1
constant: false
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 2

metaR r0970
name: Active transport
product: MODEL1310110026#
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110026#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_53d2b685_7292_457d_b1ab_6cd7dd17f360
initial amount: NaN
is: P20933
has only substance units: false
is encoded by: hsa:175
type: Species
name: AGA
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110026#_9c1c4456_a5bd_41d6_bc7a_4b0932b65ac5
type: Species
is: P36957
is encoded by: hsa:1743
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: DLST
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_17bfe07c_ed9d_4146_9e4d_afbd3d180284
initial amount: NaN
is encoded by: hsa:5152
boundary condition: true
has only substance units: false
constant: false
name: PDE9A
initial concentration: NaN
type: Species
is: SBO:0000252

metaM malcoa r
name: malonyl-CoA(4-)
is: SBO:0000247
is: HMDB01175
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
is: CHEBI:57384
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110026#_e4baa56a_9608_4c0f_80bc_0e82a440e291
initial concentration: NaN
is: P49189
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
name: ALDH9A1
type: Species
is encoded by: hsa:223
initial amount: NaN

metaR GALASE15ly
is described by: ECO:0000000
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false
is: SBO:0000176
name: beta-galactosidase, lysosomal
modifier: MODEL1310110026#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110026#
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.1.6.4

metaM dadp n
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
boundary condition: false
is: SBO:0000247
constant: false
name: dADP(3-)
is: CHEBI:57667
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB01508

metaR BHBtm
product: MODEL1310110026#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
fast: false
is described by: ECO:0000000
reactant: MODEL1310110026#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110026#_33e48bdd_aa05_41fc_9686_7b1cf11c5f5c
has only substance units: false
name: _728226_1_e
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:728226
type: Species
initial concentration: NaN
initial amount: NaN

metaR RTOTAL3FATPc
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal3 by enterocytes
type: Reaction

metaR r2116
kinetic law: MODEL1310110026#
reversible: true
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110026#
is: SBO:0000185
fast: false
is described by: ECO:0000000
reactant: MODEL1310110026#

metaR EX gmp LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GMP exchange
type: Reaction

metaM fum c
name: Fumarate
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
is: C00122
type: Species
constant: false
is: CHEBI:29806
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
is: SBO:0000247
is: HMDB00134

metaR FAOXC5C5DCc
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of glutaryl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_51495ae6_d17d_409e_84ec_ba75ed2a8bc8
has only substance units: false
name: BTD
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: P43251
boundary condition: true
is encoded by: hsa:686
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_f6148ff9_558f_472f_a140_ee5fe06d7ee4
type: Species
has only substance units: false
initial concentration: NaN
name: UGP2
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:7360

http://identifiers.org/biomodels.db/MODEL1310110026#_5ee45748_b201_4b40_ab26_5c5a2845a297
name: NT5C1B
initial concentration: NaN
is: Q96P26
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:93034
constant: false
initial amount: NaN
is: SBO:0000252

metaR OCTAt
is described by: ECO:0000000
kinetic law: MODEL1310110026#
product: MODEL1310110026#
name: Octanoate transport via diffusion
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:JLR
fast: false
reactant: MODEL1310110026#
type: Reaction
is: SBO:0000185

metaM sebacid x
notes: FORMULA: C10H16O4 CHARGE: -2
initial concentration: 1.0
type: Species
is: C08277
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB00792
constant: false
name: sebacicacid
is: SBO:0000247

metaM c226coa x
has only substance units: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205479
is: C16169
initial amount: NaN
name: cervonyl coenzyme A

metaR r2117
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110026#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reactant: MODEL1310110026#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110026#_21f63728_7a62_4ae6_b62c_fc7fb2ef4e6d
is: SBO:0000252
initial amount: NaN
is: O14732
is encoded by: hsa:3613
constant: false
boundary condition: true
type: Species
has only substance units: false
name: IMPA2
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_4884c9b5_76a6_4c7c_a3c3_9bdf47ea41ef
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
name: PDE9A
has only substance units: false
is encoded by: hsa:5152

http://identifiers.org/biomodels.db/MODEL1310110026#_d0e1028f_4b87_4875_8c74_2fcd952ce972
constant: false
name: UPP1
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: Q16831
is encoded by: hsa:7378
boundary condition: true
type: Species

metaR r2328
reactant: MODEL1310110026#
is described by: ECO:0000000
product: MODEL1310110026#
is: SBO:0000185
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
reversible: true
type: Reaction

metaR FAOXC180x
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: NOTES:- in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) NJ
reactant: MODEL1310110026#
is described by: ECO:0000269
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/1.3.3.6
reversible: false
type: Reaction
product: MODEL1310110026#
fast: false
name: Beta oxidation of long chain fatty acid

http://identifiers.org/biomodels.db/MODEL1310110026#_280779bd_04ac_436b_aa1a_b7313d5d60c4
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:5214
name: PFKP
is: Q5VSR7

metaM dhcholestanate c
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
is: HMDB00359
is: SBO:0000247
is: CHEBI:16577
has only substance units: false

metaR RE3421R
reversible: true
name: RE3421
kinetic law: MODEL1310110026#
product: MODEL1310110026#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110026#_48af8f93_2f91_455b_a17a_206f15d72b00
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
name: PANK1
is encoded by: hsa:53354
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_1e8a5d61_a821_41e2_906e_3989ba2d8e0c
is: SBO:0000252
constant: false
name: PLCB1
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is: Q9NQ66
is encoded by: hsa:23236
initial amount: NaN

metaR RE3242R
reactant: MODEL1310110026#
reversible: true
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
is described by: ECO:0000000
product: MODEL1310110026#
kinetic law: MODEL1310110026#
fast: false
modifier: MODEL1310110026#
is: SBO:0000176
name: RE3242
type: Reaction

metaR CITtam
modifier: MODEL1310110026#
name: citrate transport, mitochondrial
product: MODEL1310110026#
type: Reaction
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110026#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
fast: false
kinetic law: MODEL1310110026#

metaR DPMVDc
product: MODEL1310110026#
name: diphosphomevalonate decarboxylase, cytosol
reactant: MODEL1310110026#
modifier: MODEL1310110026#
reversible: false
kinetic law: MODEL1310110026#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (4597.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added t product for elemental balancing.
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/4.1.1.33
fast: false

metaM tmndnc e
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C20H29O2 CHARGE: -1 INCHI: InChI=1/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-
is: HMDB01999
name: timnodonic acid C20:5, n-3
type: Species
is: http://identifiers.org/pubchem.compound/446284
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_ca64d4cf_fdcc_4fdb_8aeb_e64dc3365003
has only substance units: false
name: XDH
is encoded by: hsa:7498
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is: P47989
is: SBO:0000252

metaR r2114
fast: false
product: MODEL1310110026#
kinetic law: MODEL1310110026#
type: Reaction
modifier: MODEL1310110026#
reactant: MODEL1310110026#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
is described by: ECO:0000000

metaM clpnd e
name: clupanodonic acid
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB06528
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-
constant: false
is: CHEBI:53488

metaR r2329
reversible: true
reactant: MODEL1310110026#
product: MODEL1310110026#
is: SBO:0000185
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110026#_4f53e5f7_d5f0_435e_a8d8_bfa8875180e0
constant: false
initial amount: NaN
is encoded by: hsa:4535
initial concentration: NaN
boundary condition: true
is: Q85KV6
type: Species
name: ND1
is: SBO:0000252
has only substance units: false

metaR r0973
product: MODEL1310110026#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110026#
reversible: true
name: Facilitated diffusion
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110026#_12033746_3988_41b0_aff7_4aa2670dfd92
name: VNN3
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:55350
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_720c2b4a_f163_4244_83e9_5651f1b48d51
constant: false
type: Species
initial concentration: NaN
boundary condition: true
is: P00441
is: SBO:0000252
initial amount: NaN
name: SOD1
has only substance units: false
is encoded by: hsa:6647

metaM dadp m
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
constant: false
initial amount: NaN
is: HMDB01508
boundary condition: false
has only substance units: false
is: CHEBI:57667
name: dADP(3-)

metaR r2115
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110026#
fast: false
is: SBO:0000185
reversible: true
type: Reaction
reactant: MODEL1310110026#
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#

metaM tdcrn c
is: HMDB05066
notes: FORMULA: C21H41NO4 CHARGE: 0
has only substance units: false
boundary condition: false
name: myristoyl carnitine
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaR r1164
fast: false
reactant: MODEL1310110026#
is: SBO:0000176
product: MODEL1310110026#
is described by: ECO:0000000
kinetic law: MODEL1310110026#
name: EC:2.3.1.26
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
reversible: false
type: Reaction

metaR MALTe
fast: false
is: SBO:0000176
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.2.1.20
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8972.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.20 Confidence Level: 4 AUTHORS: PMID:3143729 NOTES:IF
product: MODEL1310110026#
name: alpha-glucosidase, extracellular
type: Reaction
reactant: MODEL1310110026#
modifier: MODEL1310110026#
reversible: false

metaM lnlc r
is: CHEBI:30245
is: HMDB00673
constant: false
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC00796 EHMN_ABBREVIATION: C01595
name: linoleate
initial concentration: 1.0
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110026#_95d937d0_bba0_4b7c_8cee_06855b625439
is: SBO:0000252
initial concentration: NaN
type: Species
name: GMPPA
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:29926
is: Q96IJ6

metaR r0603
fast: false
type: Reaction
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
modifier: MODEL1310110026#
is described by: ECO:0000000
reactant: MODEL1310110026#
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.3.1.12
kinetic law: MODEL1310110026#

metaR r1167
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110026#
is described by: ECO:0000000
reversible: false
name: EC:2.3.1.26
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110026#_23bd31bd_1896_4997_b49d_096504f0ec62
is: P49327
is encoded by: hsa:2194
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
constant: false
name: FASN

metaM gal l
is: SBO:0000247
has only substance units: false
name: D-galactose
constant: false
is: CHEBI:12936
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124
is: HMDB00143

metaM apoC Lys c
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB00182
type: Species
is: CHEBI:32551
notes: FORMULA: C6H13N2OX CHARGE: 0
has only substance units: false
constant: false
name: Apocarboxylase (Lys residue)

metaM ocdcea r
is: HMDB00207
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C18H33O2 CHARGE: -1
is: C00712
name: octadecenoate (n-C18:1)
type: Species
constant: false
is: CHEBI:0

metaR r2439
reversible: false
type: Reaction
reactant: MODEL1310110026#
is described by: ECO:0000000
product: MODEL1310110026#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12759755 NOTES:
name: Zinc (Zn2+)-Iron (Fe2+) Permease (ZIP), TCDB:2.A.53.2.2

http://identifiers.org/biomodels.db/MODEL1310110026#_2bbc05ae_d64b_4af4_9258_cb6288674cb9
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5230
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
is: P00558
type: Species
name: PGK1

metaM acac c
constant: false
name: acetoacetate
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
initial concentration: 1.0
boundary condition: false
is: HMDB00060
type: Species
is: CHEBI:13705
has only substance units: false

metaR IVCRNe
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of isovaleryl carnitine into the extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_afa3438e_73f7_422c_989b_89fc97504e5c
is encoded by: hsa:LOC647190
type: Species
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
name: _LOC647190_1_c
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_c7f74897_ca3b_49a0_820c_c04636a707cb
constant: false
name: B3GNT7
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:93010
is: Q8NFL0
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR PHETHPTOX2
is described by: ECO:0000269
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)
fast: false
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (5053.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.14.16.1 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:9450897 NOTES:SAB unlumped form of PHETHPTOX according to PMID 10727395
modifier: MODEL1310110026#
type: Reaction
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.14.16.1
product: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_26cdb91f_64ef_4d83_b660_df9ba03d6afb
name: SDHC
constant: false
type: Species
is encoded by: hsa:6391
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: Q99643
boundary condition: true
initial concentration: NaN

metaM arach c
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
constant: false
name: arachidate
type: Species
is: SBO:0000247
is: HMDB02212
boundary condition: false
is: CHEBI:32360
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_7b867a3a_15a5_4873_bc15_f822a195c089
initial concentration: NaN
name: SLC43A2
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
is: Q8N370
is encoded by: hsa:124935

metaM decdicrn e
has only substance units: false
notes: FORMULA: C17H29NO4 CHARGE: 0
name: decadienoyl carnitine
is: HMDB13325
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false

metaM hexccoa c
notes: FORMULA: C47H82N7O17P3S CHARGE: -4 INCHI: InChI=1/C47H86N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27-38(56)75-31-30-49-37(55)28-29-50-45(59)42(58)47(2,3)33-68-74(65,66)71-73(63,64)67-32-36-41(70-72(60,61)62)40(57)46(69-36)54-35-53-39-43(48)51-34-52-44(39)54/h34-36,40-42,46,57-58H,4-33H2,1-3H3,(H,49,55)(H,50,59)(H,63,64)(H,65,66)(H2,48,51,52)(H2,60,61,62)/p-4/t36-,40-,41-,42+,46-/m1/s1
name: Hexacosanoyl-CoA (n-C26:0CoA)
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB06459
type: Species
boundary condition: false

metaM sebcoa x
type: Species
is: SBO:0000247
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
has only substance units: false
constant: false
name: sebacoylcoa
initial concentration: 1.0
is: HMDB02014
initial amount: NaN
boundary condition: false

metaR SPMTDe
fast: false
is described by: ECO:0000134
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110026#
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: SPMTDe
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_ee5d7a34_54bc_4ad8_8d7c_0080b0ddd6dd
initial concentration: NaN
constant: false
is encoded by: hsa:122970
has only substance units: false
is: SBO:0000252
name: ACOT4
initial amount: NaN
is: Q8N9L9
type: Species
boundary condition: true

metaM pyr e
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: CHEBI:15361
is: SBO:0000247
constant: false
initial concentration: 1.0
name: pyruvate
is: HMDB00243

metaR MM7B2g
is version of: http://identifiers.org/ec-code/3.2.1.113
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
is described by: ECO:0000000
product: MODEL1310110026#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
reversible: false
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110026#_0be18c42_6a82_4e7f_b73b_9a019d0e53ed
constant: false
name: NDUFA1
is: Q6IBB5
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:4694
has only substance units: false

metaM 4hbz m
has only substance units: false
is: SBO:0000247
notes: FORMULA: C7H5O3 CHARGE: -1 INCHI: InChI=1S/C7H6O3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H,(H,9,10)/p-1
is: HMDB00500
is: CHEBI:17879
name: 4-hydroxybenzoate
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_7a5e7a24_3ea1_49dd_98ab_0ebe42c4286c
is: Q6ZWP6
is: SBO:0000252
name: ACAD8
constant: false
boundary condition: true
is encoded by: hsa:27034
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN

metaR EX retinol LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_a4488537_1b1b_4c4a_92e8_dbfc579f5f1d
is: P33908
name: MAN1A1
type: Species
has only substance units: false
is encoded by: hsa:4121
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN

metaR RE1254C
fast: false
kinetic law: MODEL1310110026#
is: SBO:0000176
type: Reaction
product: MODEL1310110026#
reversible: true
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
is described by: ECO:0000000
name: RE1254

metaR r0317
is described by: ECO:0000000
kinetic law: MODEL1310110026#
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/2.1.2.10
type: Reaction
modifier: MODEL1310110026#
product: MODEL1310110026#
reversible: true
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.4.4.2

metaR r1168
is: SBO:0000176
kinetic law: MODEL1310110026#
is described by: ECO:0000000
name: EC:2.3.1.26
fast: false
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
type: Reaction
reversible: false
reactant: MODEL1310110026#

metaM taur x
type: Species
notes: FORMULA: C2H7NO3S CHARGE: 0 INCHI: InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00222 EHMN_ABBREVIATION: C00245
boundary condition: false
is: HMDB00251
is: CHEBI:15891
name: taurine
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaM dgmp c
boundary condition: false
is: SBO:0000247
is: C00362
name: dGMP
constant: false
is: HMDB01044
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
is: CHEBI:57673
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_785f9fbb_99e5_41ce_9b5d_69d114438864
has part: P06576
is encoded by: hsa:498
initial concentration: NaN
has part: A8K092
constant: false
boundary condition: true
is encoded by: hsa:513
has part: P56381
initial amount: NaN
is encoded by: hsa:514
type: Species
is encoded by: hsa:506
has part: P36542
has part: P30049
is encoded by: hsa:509
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
has only substance units: false
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110026#_6368aa37_acf1_4d44_a2ec_c7a151c3417f
boundary condition: true
name: ACAD10
is encoded by: hsa:80724
type: Species
constant: false
initial concentration: NaN
is: G3XAJ0
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaM acac e
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: acetoacetate
is: HMDB00060
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
type: Species
is: CHEBI:13705
constant: false

metaM r5p c
initial concentration: 1.0
constant: false
has only substance units: false
name: alpha-D-Ribose 5-phosphate
initial amount: NaN
type: Species
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
is: HMDB00618
is: SBO:0000247
is: CHEBI:18189
boundary condition: false
is: C00117

metaM pyr c
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/3324
is: C00022
name: pyruvate
notes: FORMULA: C3H3O3 CHARGE: -1
type: Species
is: CHEBI:15361
boundary condition: false
is: HMDB00243
is: SBO:0000247

metaR EX glyc S LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (S)-Glycerate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_5831cd4e_0137_4516_bfe1_1c99f7046394
is: P22392
has only substance units: false
is: SBO:0000252
name: NME2
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4831
type: Species

metaM HC00460 c
constant: false
has only substance units: false
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
is: CHEBI:58044
type: Species
name: 2,5-dihydroxybenzoate
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaM prpncoa m
initial amount: NaN
is: HMDB02307
is: CHEBI:57367
constant: false
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
initial concentration: 1.0
boundary condition: false
name: acryloyl-CoA(4-)
has only substance units: false
type: Species
is: SBO:0000247

metaM fol c
type: Species
has only substance units: false
is: HMDB00121
initial concentration: 1.0
name: Folate
constant: false
notes: FORMULA: C19H18N7O6 CHARGE: -1
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaR DOLPMT U
product: MODEL1310110026#
reversible: false
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
name: Dolichyl-phosphate D-mannosyltransferase (uterus)
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.4.1.83
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (54344.2 and 8818.1 and 8813.1) or (8818.2 and 54344.1 and 8813.1) or (8818.1 and 54344.1 and 8813.1) or (54344.2 and 8818.2 and 8813.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.83 Confidence Level: 0 AUTHORS: PMID:11420690 NOTES:NCD
fast: false

metaR EX ddece1crn
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dodecenoyl carnitine
type: Reaction

metaR EX ahdt LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 7,8-dihydroneopterin 3-triphosphate(4-)
type: Reaction

metaR LGNCCOAtx
product: MODEL1310110026#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reactant: MODEL1310110026#
is: SBO:0000185
fast: false
reversible: true
kinetic law: MODEL1310110026#
is described by: ECO:0000000
name: fatty acid intracellular transport

metaM dhcholestanate m
initial amount: NaN
constant: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
is: CHEBI:16577
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB00359
boundary condition: false
initial concentration: 1.0

metaR DUDPtn
type: Reaction
fast: false
name: dUDP nuclear transport
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: true

metaM 4hpro LT e
constant: false
has only substance units: false
name: trans-4-hydroxy-L-proline
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
is: HMDB00725
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species

metaR MEVK1c
reactant: MODEL1310110026#
product: MODEL1310110026#
fast: false
reversible: false
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (4598.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book.
name: mevalonate kinase (atp) cytosol
is described by: ECO:0000134
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.36
type: Reaction
modifier: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_474a07e4_b1e7_4a14_b0ba_16876c1a9b4d
has only substance units: false
type: Species
constant: false
boundary condition: true
is: D9HTE9
is: SBO:0000252
name: SLC25A1
initial concentration: NaN
is encoded by: hsa:6576
initial amount: NaN

metaM dutp c
initial amount: NaN
is: HMDB01191
has only substance units: false
boundary condition: false
is: CHEBI:17625
is: C00460
type: Species
name: dUTP
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: SBO:0000247
constant: false
initial concentration: 1.0

metaM dgmp e
boundary condition: false
type: Species
is: HMDB01044
name: dGMP(2-)
has only substance units: false
initial amount: NaN
is: CHEBI:57673
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362

metaR EX fe3 LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Fe3+ exchange
type: Reaction

metaR GLACter
name: D-glucurono-6,3-lactone transport, endoplasmic reticulum
type: Reaction
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:3779687 NOTES:NCD
product: MODEL1310110026#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110026#_05be6480_f6d7_4a20_bd8b_1440a9a0468f
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:10026
has part: Q92643
has part: Q9H490
initial concentration: NaN
has part: O43292
is encoded by: hsa:128869
is encoded by: hsa:51604
is encoded by: hsa:8733
has part: Q969N2
constant: false
has part: Q8NBL9
is encoded by: hsa:94005
has only substance units: false
type: Species
name: PIGK:PIGU:PIGT:GPAA1:PIGS
boundary condition: true

metaM dhcholestancoa x
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB02159
is: CHEBI:15494
boundary condition: false
constant: false
type: Species
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA

metaR EX mercplaccys LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-mercaptolactate-cysteine disulfide exchange
type: Reaction

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

metaR URIDK2m
type: Reaction
reactant: MODEL1310110026#
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:IT
is: SBO:0000176
reversible: true
product: MODEL1310110026#
name: uridylate kinase (dUMP), mitochondrial

metaM 4hpro LT c
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:18095
boundary condition: false
name: trans-4-hydroxy-L-proline
is: HMDB00725
initial amount: NaN
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690

http://identifiers.org/biomodels.db/MODEL1310110026#_381ab6d4_6a54_4f0f_a2cc_adab27076501
initial amount: NaN
is: P25705
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: ATP5A1
is encoded by: hsa:498
type: Species
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110026#_5731320f_9bcb_45df_bf56_3c696200b044
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
is: P13995
name: MTHFD2
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:10797

metaR NDPK2n
is described by: ECO:0000269
name: nucleoside-diphosphate kinase (ATP:UDP), nuclear
modifier: MODEL1310110026#
type: Reaction
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
is: SBO:0000176
product: MODEL1310110026#
reversible: true

metaR EX leuktrB4 LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene B4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_1451b222_f9e1_4020_a5e0_652dfe1e2aae
initial concentration: NaN
is encoded by: hsa:3030
boundary condition: true
type: Species
has only substance units: false
name: HADHA
is: E9KL44
constant: false
initial amount: NaN
is: SBO:0000252

metaR r0539
reversible: true
product: MODEL1310110026#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:
name: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19
type: Reaction
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.34
modifier: MODEL1310110026#

metaR EX ribflv LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Riboflavin
type: Reaction

metaR EX cspg a LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan exchange
type: Reaction

metaR FAOXC80
reactant: MODEL1310110026#
is: SBO:0000176
kinetic law: MODEL1310110026#
is described by: ECO:0000269
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TDV (9/7/2004) Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
modifier: MODEL1310110026#
name: Beta oxidation of med/long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false

metaM decdicrn c
initial amount: NaN
constant: false
type: Species
boundary condition: false
notes: FORMULA: C17H29NO4 CHARGE: 0
name: decadienoyl carnitine
initial concentration: 1.0
is: SBO:0000247
is: HMDB13325
has only substance units: false

metaM arach e
is: SBO:0000247
is: HMDB02212
name: arachidate
initial concentration: 1.0
is: CHEBI:32360
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_251b223d_6e12_4204_9dbc_2fe307d6d6a6
name: ST3GAL3
is encoded by: hsa:6487
is: SBO:0000252
has only substance units: false
constant: false
type: Species
is: Q5T4W8
boundary condition: true
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_06a89daa_2f7c_4186_9885_2d3927d74b22
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
name: _286297_1_c
is encoded by: hsa:286297
has only substance units: false

metaR EX hexc LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexacosanoate (n-C26:0) exchange
type: Reaction

metaM adrncoa x
is: SBO:0000247
is: C16170
initial concentration: 1.0
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205480
boundary condition: false
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
type: Species
constant: false
name: adrenyl coenzyme A
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_bea2c1f6_a010_4ab5_a624_c7bd46d48f33
name: EHHADH:ACAA1:ACOX1
has part: Q9NY65
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000297
has only substance units: false
is encoded by: hsa:1962
boundary condition: true

metaR NTD7
product: MODEL1310110026#
modifier: MODEL1310110026#
name: 5'-nucleotidase (AMP)
is: SBO:0000176
reversible: false
fast: false
notes: GENE_ASSOCIATION: (22978.1) or (93034.2) or (93034.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is described by: ECO:0000269
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.1.3.5
type: Reaction
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_8b556543_2e40_4c62_8348_ce194375f67b
name: FUCA1
type: Species
constant: false
is: SBO:0000252
is: P04066
has only substance units: false
initial amount: NaN
is encoded by: hsa:2517
boundary condition: true
initial concentration: NaN

metaM odecoa r
name: oleoyl-CoA(4-)
has only substance units: false
initial concentration: 1.0
is: CHEBI:57387
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,26-28,32-34,38,49-50H,4-10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-/t28-,32-,33-,34+,38-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
boundary condition: false
is: HMDB01322

http://identifiers.org/biomodels.db/MODEL1310110026#_fd678b09_6f31_431b_bcdf_086a9186f961
type: Species
has only substance units: false
name: SLC27A1
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:376497
constant: false
is: Q6PCB7

metaR ACETONEt2
fast: false
reversible: true
is: SBO:0000185
name: acetone transport via proton symport
modifier: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
type: Reaction
product: MODEL1310110026#
kinetic law: MODEL1310110026#
is described by: ECO:0000269

metaR PSERT
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.6.1.52
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (29968.1) or (29968.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.52 Confidence Level: 4 AUTHORS: PMID:12633500 NOTES:
name: phosphoserine transaminase
product: MODEL1310110026#
reversible: false
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_79cdec57_c506_44c3_b5c1_84e83728aa3d
boundary condition: true
is encoded by: hsa:2678
name: GGT1
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false

metaR r0836
reversible: true
is version of: http://identifiers.org/ec-code/3.5.4.16
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
fast: false
is: SBO:0000185
product: MODEL1310110026#
is described by: ECO:0000000

metaR r0547
is version of: http://identifiers.org/ec-code/1.17.1.4
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction
name: Aldehyde:NADP+ oxidoreductase Phenylalanine metabolism EC:1.2.1.5
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
product: MODEL1310110026#
reactant: MODEL1310110026#
modifier: MODEL1310110026#
is: SBO:0000176
kinetic law: MODEL1310110026#

metaR NTD6
is version of: http://identifiers.org/ec-code/3.1.3.5
reactant: MODEL1310110026#
reversible: false
product: MODEL1310110026#
name: 5'-nucleotidase (dAMP)
is: SBO:0000176
type: Reaction
is described by: ECO:0000134
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31

metaR FBA
is: SBO:0000176
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (230.1) or (229.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:12626877,PMID:6765112 NOTES:6765112 - fluorescence of presence in human brain
fast: false
product: MODEL1310110026#
kinetic law: MODEL1310110026#
type: Reaction
name: fructose-bisphosphate aldolase
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/4.1.2.13
reversible: true
modifier: MODEL1310110026#

metaR q10h2tc
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000134
name: transport of ubiquinol into cytosol
product: MODEL1310110026#
is: SBO:0000185
fast: false
type: Reaction
reversible: true

metaR RE0512M
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
reversible: true
name: RE0512
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_8d0ad5c8_c730_4584_8288_6a231b0c06e7
name: SLC7A5
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
is: Q8IV97
is encoded by: hsa:8140
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_f556ba40_bff8_4f85_b154_5e7f1e6dff22
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
has only substance units: false
name: GGT1
is: P19440
is encoded by: hsa:2678

metaM anth e
type: Species
constant: false
has only substance units: false
is: HMDB01123
boundary condition: false
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16567
name: anthranilate
initial amount: NaN

metaR EX 5oxpro LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-oxoprolinate
type: Reaction

metaM arg L m
is: SBO:0000247
name: L-argininium(1+)
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:32682
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: HMDB00517

metaM leugly c
name: Leucylglycine
constant: false
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C8H16N2O3 CHARGE: 0
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/97364
initial amount: NaN

metaM HC01522 c
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
name: Gentisate aldehyde
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585
initial amount: NaN
type: Species
is: CHEBI:28508
boundary condition: false

metaM pheme e
is: C00032
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
name: Protoheme
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:17627
is: HMDB03178

metaR LEUTA
reversible: true
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110026#
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
name: leucine transaminase
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.42
product: MODEL1310110026#
is: SBO:0000176
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42

metaM CE5118 m
has only substance units: false
is: SBO:0000247
name: trans-2-cis,cis-4,8-tetradecatrienoyl-CoA
type: Species
initial amount: NaN
is: CHEBI:57923
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,12-15,22-24,28-30,34,45-46H,4-7,10-11,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,13-12-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5118
constant: false

metaM dcsptn1crn c
initial concentration: 1.0
is: HMDB06321
name: docosa-4,7,10,13,16-pentaenoyl carnitine
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110026#_c018a62f_a877_445a_a5a9_cc93f27ef4d2
type: Species
is: Q9NY97
name: B3GNT2
boundary condition: true
is encoded by: hsa:10678
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaR SUCCtp
reactant: MODEL1310110026#
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
kinetic law: MODEL1310110026#
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000185
fast: false
name: succinate transporter, peroxisome

http://identifiers.org/biomodels.db/MODEL1310110026#_2d7fc898_4e00_465a_9ab1_5356cdb1db32
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: P16499
type: Species
constant: false
name: PDE6A
is: SBO:0000252
is encoded by: hsa:5145

metaR AG13T3g
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110026#
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false
is: SBO:0000176
product: MODEL1310110026#
fast: false
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
type: Reaction
notes: GENE_ASSOCIATION: (10331.1) or (11041.1) or (374907.2) or (10678.1) or (79369.1) or (374907.1) or (10678.2) or (93010.1) or (146712.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

metaR r0834
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reactant: MODEL1310110026#
modifier: MODEL1310110026#
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110026#
product: MODEL1310110026#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.5.4.16
is described by: ECO:0000000

metaM Ser Gly Ala X Gly l
initial amount: NaN
is: CHEBI:36005
name: protein-linked serine residue (glycosaminoglycan attachment site)
notes: FORMULA: XH CHARGE: 0
boundary condition: false
constant: false
type: Species
is: HMDB02183
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaR r0549
is described by: ECO:0000000
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/6.1.1.17
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
is: SBO:0000176
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.6.5.3
is version of: http://identifiers.org/ec-code/1.6.99.3
modifier: MODEL1310110026#

metaM malt e
name: Maltose
initial amount: NaN
has only substance units: false
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00194 EHMN_ABBREVIATION: C00208
is: CHEBI:17306
is: C00208
is: HMDB00163
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false

metaM leugly e
constant: false
name: Leucylglycine
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/97364
initial concentration: 1.0
notes: FORMULA: C8H16N2O3 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110026#_51487b20_1bd1_4d52_a3dd_14df19615997
constant: false
boundary condition: true
name: GLUD1
is: E9KL48
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:2746
initial amount: NaN
initial concentration: NaN

metaM retn e
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
type: Species
is: SBO:0000247
is: CHEBI:35291
name: all-trans-retinoate
has only substance units: false
is: HMDB01852

http://identifiers.org/biomodels.db/MODEL1310110026#_b241ac11_66ac_4e6b_852d_f03ccc66715f
initial amount: NaN
name: SLC12A7
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:10723
initial concentration: NaN
constant: false
is: Q9Y666

metaR RE2659R
kinetic law: MODEL1310110026#
fast: false
product: MODEL1310110026#
type: Reaction
reversible: true
is: SBO:0000176
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
is described by: ECO:0000000
name: RE2659

http://identifiers.org/biomodels.db/MODEL1310110026#_98b6335a_75e8_48d9_b4fd_817bee53453c
is: P30837
has only substance units: false
constant: false
name: ALDH1B1
is encoded by: hsa:219
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN

metaM dutp n
initial concentration: 1.0
name: dUTP
has only substance units: false
type: Species
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
constant: false
is: CHEBI:17625
boundary condition: false
is: HMDB01191
is: SBO:0000247
initial amount: NaN

metaR FAOXC140
type: Reaction
kinetic law: MODEL1310110026#
is described by: ECO:0000269
fast: false
product: MODEL1310110026#
modifier: MODEL1310110026#
name: Beta oxidation of long chain fatty acid
is: SBO:0000176
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110026#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110026#_0f490758_b805_47c9_8415_9791204a0d01
is: Q5JWV8
type: Species
name: ACSL4
initial amount: NaN
is encoded by: hsa:2182
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_497dc7df_91d0_4874_ae23_35f165d8e0d8
name: ECH1
is encoded by: hsa:1891
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
is: Q13011
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_30ada7d6_5def_4285_b2b8_07f4ce310707
constant: false
is encoded by: hsa:6487
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
name: ST3GAL3
boundary condition: true
is: SBO:0000252

metaM apoC Lys m
initial concentration: 1.0
constant: false
is: CHEBI:32551
boundary condition: false
notes: FORMULA: C6H13N2OX CHARGE: 0
is: SBO:0000247
name: Apocarboxylase (Lys residue)
has only substance units: false
type: Species
initial amount: NaN
is: HMDB00182

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_38b3c497_be90_4a2a_824f_6b556cccf799
constant: false
boundary condition: true
initial amount: NaN
name: DGKG
type: Species
is: SBO:0000252
has only substance units: false
is: P49619
is encoded by: hsa:1608
initial concentration: NaN

metaM frdp r
initial amount: NaN
type: Species
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
initial concentration: 1.0
name: Farnesyl diphosphate
is: SBO:0000247
is: C00448
boundary condition: false
is: CHEBI:175763
constant: false
has only substance units: false
is: HMDB00961

metaM fald c
boundary condition: false
initial concentration: 1.0
is: HMDB01426
initial amount: NaN
has only substance units: false
name: formaldehyde
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
is: CHEBI:16842
is: SBO:0000247
constant: false
type: Species

metaR SIAASE3ly
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
name: sialidase, lysosomal
reactant: MODEL1310110026#
modifier: MODEL1310110026#
is described by: ECO:0000000
kinetic law: MODEL1310110026#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4

metaM 3hpcoa m
name: 3-hydroxypropanoyl-CoA(4-)
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB06807
is: CHEBI:58528
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false

metaR PIK3
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.7.11.1
modifier: MODEL1310110026#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.153
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5290.1 and 5295.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.3) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5295.2 and 5290.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7628435,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.1.137
is version of: http://identifiers.org/ec-code/2.7.1.154
is described by: ECO:0000000
name: phosphatidylinositol 3-kinase
reversible: false
fast: false

metaM retn c
is: CHEBI:35291
initial concentration: 1.0
constant: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: all-trans-retinoate
is: HMDB01852
boundary condition: false
type: Species

metaM dcamp c
is: CHEBI:57567
boundary condition: false
has only substance units: false
constant: false
is: HMDB00536
name: N6-(1,2-Dicarboxyethyl)-AMP
is: SBO:0000247
initial amount: NaN
is: C03794
type: Species
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
initial concentration: 1.0

metaR r0830
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110026#
is: SBO:0000185
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is version of: http://identifiers.org/ec-code/3.5.4.16
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reactant: MODEL1310110026#
type: Reaction
fast: false
modifier: MODEL1310110026#

metaM odecoa x
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,26-28,32-34,38,49-50H,4-10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-/t28-,32-,33-,34+,38-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
is: HMDB01322
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
is: SBO:0000247
name: oleoyl-CoA(4-)
is: CHEBI:57387
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_123a3989_7d63_498d_8860_283aaf9b1324
is: P21217
initial concentration: NaN
boundary condition: true
name: FUT3
is: SBO:0000252
constant: false
is encoded by: hsa:2525
initial amount: NaN
type: Species
has only substance units: false

metaR 3DSPHR
product: MODEL1310110026#
name: 3-Dehydrosphinganine reductase
kinetic law: MODEL1310110026#
type: Reaction
fast: false
reactant: MODEL1310110026#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2531.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 1.1.1.102 Confidence Level: 4 AUTHORS: NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.102
modifier: MODEL1310110026#

metaR sink c81coa LPAREN c RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: C81COASINK
type: Reaction

metaR NMNS
reactant: MODEL1310110026#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110026#
reversible: false
fast: false
is described by: ECO:0000134
name: NMN synthetase
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:19513556 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110026#_a58ceaeb_f1a3_42a2_8eb8_21e21e036c26
has only substance units: false
is: P31639
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6524
constant: false
type: Species
name: SLC5A2
boundary condition: true
initial amount: NaN

metaR r0545
reversible: true
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
is described by: ECO:0000000
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
product: MODEL1310110026#
modifier: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.5
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_a98d79e6_e830_495f_b12c_17b380662f15
is: SBO:0000252
is: Q8NFM4
is encoded by: hsa:196883
type: Species
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: ADCY4

metaR FAOXC16DCr
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16DC)er
type: Reaction

metaM dutp m
name: dUTP
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:17625
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: HMDB01191
type: Species
constant: false
initial amount: NaN

metaR RE1903R
reactant: MODEL1310110026#
product: MODEL1310110026#
kinetic law: MODEL1310110026#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
name: RE1903
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:

metaR G6Pter
is: SBO:0000185
product: MODEL1310110026#
reversible: true
name: glucose 6-phosphate endoplasmic reticular transport via diffusion
is described by: ECO:0000269
reactant: MODEL1310110026#
fast: false
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (2542.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11032333,PMID:11140953,PMID:11879177,PMID:9428641 NOTES:NCD
type: Reaction

metaM fald e
constant: false
has only substance units: false
name: formaldehyde
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB01426
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
boundary condition: false
is: SBO:0000247
is: CHEBI:16842

metaR NODe
name: NODe
product: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
reactant: MODEL1310110026#
is described by: ECO:0000134
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110026#_232281ce_1e78_447c_88a0_8b1408411aeb
constant: false
is: B7Z5T8
has only substance units: false
initial concentration: NaN
name: CPT1B
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:1375
initial amount: NaN

metaM pheme c
is: SBO:0000247
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
constant: false
name: Protoheme
boundary condition: false
type: Species
is: HMDB03178
is: CHEBI:17627
has only substance units: false
initial amount: NaN
is: C00032
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110026#_1885434e_578a_4b28_a311_675edd83518f
has only substance units: false
boundary condition: true
name: NDUFB6
is encoded by: hsa:4712
is: Q5VYT2
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
initial amount: NaN

metaM anth c
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB01123
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
type: Species
constant: false
name: anthranilate
is: SBO:0000247
is: CHEBI:16567

metaR GLYCt
reversible: true
kinetic law: MODEL1310110026#
type: Reaction
fast: false
name: glycerol transport via channel
reactant: MODEL1310110026#
is described by: ECO:0000000
product: MODEL1310110026#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD

metaR r0989
is: SBO:0000185
name: Postulated transport reaction
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
kinetic law: MODEL1310110026#
fast: false
reactant: MODEL1310110026#
reversible: true
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_b3ff0c83_bb40_4b9a_8451_ef59fbf4eb81
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: P36551
name: CPOX
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1371

http://identifiers.org/biomodels.db/MODEL1310110026#_af8a7212_7a4d_4bae_8252_67e8e8b72eeb
is: Q8WWX8
is: SBO:0000252
has only substance units: false
boundary condition: true
name: SLC5A11
constant: false
initial amount: NaN
is encoded by: hsa:115584
type: Species
initial concentration: NaN

metaR CSNAT2x
name: carnitine dimethyl nonanoyl transferase, revsible, peroxisomal
is version of: http://identifiers.org/ec-code/2.3.1.137
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.7
product: MODEL1310110026#
is: SBO:0000176
modifier: MODEL1310110026#
is described by: ECO:0000269
kinetic law: MODEL1310110026#
type: Reaction
notes: GENE_ASSOCIATION: (54677.1) or (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:15464416,PMID:7829107 NOTES:NJ
reactant: MODEL1310110026#
fast: false

metaM arg L e
type: Species
initial amount: NaN
is: HMDB00517
has only substance units: false
is: SBO:0000247
boundary condition: false
name: L-argininium(1+)
constant: false
is: CHEBI:32682
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
initial concentration: 1.0

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

metaR COt
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
product: MODEL1310110026#
reversible: true
is described by: ECO:0000000
name: CO transporter via diffusion
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#

metaR ENGASE2ly
is described by: ECO:0000000
reactant: MODEL1310110026#
is: SBO:0000176
name: endo-beta-N-acetylglucosaminidase, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
fast: false
kinetic law: MODEL1310110026#
type: Reaction
product: MODEL1310110026#

metaM dlnlcg c
has only substance units: false
is: CHEBI:53486
type: Species
constant: false
name: dihomo-gamma-linolenic acid (n-6)
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
initial concentration: 1.0
is: HMDB02925

metaM pglyc hs c
initial amount: NaN
notes: FORMULA: CHARGE: 0
is: CHEBI:21338
type: Species
initial concentration: 1.0
name: pglyc_hs[c]
is: HMDB02704
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_7d124319_bff6_457c_b06e_80874a03ee6a
has only substance units: false
is encoded by: hsa:55825
is: Q9BY49
boundary condition: true
name: PECR
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_a7c8b047_e926_4a51_ada7_ed043602473a
boundary condition: true
constant: false
name: DECR1
is encoded by: hsa:1666
is: Q16698
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR FAOXC2442246x
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: false
kinetic law: MODEL1310110026#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110026#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c24:4,n-6 -> c22:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
product: MODEL1310110026#
type: Reaction
modifier: MODEL1310110026#

metaM HC01410 m
is: CHEBI:28706
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
name: (2E)-Hexenoyl-CoA

metaM sebacid c
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: C08277
is: HMDB00792
type: Species
initial amount: NaN
name: sebacicacid
notes: FORMULA: C10H16O4 CHARGE: -2
constant: false

metaR B3GNT39g
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
reversible: false
type: Reaction
fast: false
is: SBO:0000176
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus

metaR MGCHrm
is version of: http://identifiers.org/ec-code/4.2.1.18
reactant: MODEL1310110026#
is: SBO:0000176
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (549.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.18 Confidence Level: 4 AUTHORS: PMID:12434311,PMID:3082934 NOTES:MM
kinetic law: MODEL1310110026#
is described by: ECO:0000269
type: Reaction
name: methylglutaconyl-CoA hydratase (reversible), mitochondrial
fast: false
modifier: MODEL1310110026#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110026#_25c46400_4cb5_4a66_abff_97382ce3a1ff
name: PDE6A:PDE6H:PDE6B
has part: B7Z9T9
has part: P16499
is: SBO:0000297
boundary condition: true
has part: Q13956
constant: false
is encoded by: hsa:5149
is encoded by: hsa:5145
initial concentration: NaN
is encoded by: hsa:5158
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_aec4d5be_274a_4813_a536_3765ae3be995
is: P49441
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:3628
initial concentration: NaN
name: INPP1
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_af43c68f_f26e_446b_9ee8_1f5888119388
boundary condition: true
type: Species
name: NDUFS6
initial concentration: NaN
initial amount: NaN
constant: false
is: Q6IBC4
is: SBO:0000252
is encoded by: hsa:4726
has only substance units: false

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

metaM frdp c
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: CHEBI:175763
name: Farnesyl diphosphate
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
is: HMDB00961
initial amount: NaN
is: C00448

metaM taur e
constant: false
is: CHEBI:3544
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C2H7NO3S CHARGE: 0
type: Species
is: C00245
is: HMDB00251
has only substance units: false
name: Taurine

http://identifiers.org/biomodels.db/MODEL1310110026#_0284cedb_9114_4ef1_a7a2_cea7ec90db27
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
is: Q96RN1
has only substance units: false
name: SLC26A8
constant: false
initial concentration: NaN
is encoded by: hsa:116369

metaR r0541
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
product: MODEL1310110026#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.1.5
reversible: true
modifier: MODEL1310110026#
fast: false
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:

metaR FAOXC16BRx
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16br)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_36cb0ab0_df26_46b3_9d10_adba2ebc5468
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
name: SLC2A10
is encoded by: hsa:81031
is: O95528
has only substance units: false
is: SBO:0000252
boundary condition: true

metaM arg L c
type: Species
has only substance units: false
initial amount: NaN
name: L-argininium(1+)
is: HMDB00517
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
constant: false
is: CHEBI:32682
initial concentration: 1.0

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

metaM 5mthf c
is: C00440
type: Species
constant: false
notes: FORMULA: C20H24N7O6 CHARGE: -1
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB01396
is: CHEBI:3729
initial amount: NaN
initial concentration: 1.0
name: 5-Methyltetrahydrofolate

metaR MALSO3tm
is: SBO:0000185
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
type: Reaction
fast: false
is described by: ECO:0000269
reactant: MODEL1310110026#
product: MODEL1310110026#
reversible: true
kinetic law: MODEL1310110026#
name: Malate:sulfite antiport, mitochondrial

metaM pac c
name: phenylacetate
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:18401
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
initial amount: NaN
has only substance units: false
is: HMDB00209
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110026#_15c96542_def4_42d4_80be_4485ee99b128
is: SBO:0000252
initial concentration: NaN
is: B4DJQ3
initial amount: NaN
is encoded by: hsa:6472
has only substance units: false
constant: false
type: Species
boundary condition: true
name: SHMT2

metaM acgam r
is: CHEBI:17411
type: Species
boundary condition: false
initial concentration: 1.0
name: N-acetyl-D-glucosamine
is: SBO:0000247
constant: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
initial amount: NaN
is: HMDB00215
has only substance units: false

metaR EX ascb L LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Ascorbate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_75775d84_d3c3_4a0a_83ac_d86032de0720
name: SLC35D1
initial amount: NaN
is encoded by: hsa:23169
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: Q9NTN3
constant: false
has only substance units: false
type: Species

metaM clpnd c
is: CHEBI:53488
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-
is: SBO:0000247
is: HMDB06528
boundary condition: false
has only substance units: false
name: clupanodonic acid
initial amount: NaN

metaR EX sfcys LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for sulfocysteine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_de7846f8_1729_4b8c_a28c_a1b41b4bacae
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: SBO:0000252
boundary condition: true
is: O95168
name: NDUFB4
is encoded by: hsa:4710
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_a6721c7e_3969_4cf5_84b6_46fdc7c16d34
type: Species
name: AGXT2
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:64902
initial amount: NaN
is: Q9BYV1

http://identifiers.org/biomodels.db/MODEL1310110026#_500ef6a2_58b8_403b_960b_8b27e1f0c81e
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: E9KL44
boundary condition: true
name: HADHA
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:3030

metaM pail3p hs n
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
is: CHEBI:58088
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C04549
initial amount: NaN
has only substance units: false

metaR r2321
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110026#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110026#_af9ea85a_ef23_4d36_9917_94dfd9ff0279
is: E7EPA7
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:7086
constant: false
name: TKT

metaR ADK3m
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
fast: false
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.7.4.10
reactant: MODEL1310110026#
reversible: true
modifier: MODEL1310110026#
type: Reaction
is: SBO:0000176
name: adentylate kinase (GTP)
is described by: ECO:0000269

metaM 5mthf e
constant: false
initial concentration: 1.0
is: HMDB01396
has only substance units: false
notes: FORMULA: C20H24N7O6 CHARGE: -1
boundary condition: false
is: SBO:0000247
is: CHEBI:3729
initial amount: NaN
is: C00440
type: Species
name: 5-Methyltetrahydrofolate

http://identifiers.org/biomodels.db/MODEL1310110026#_0cb5ecba_1aee_4906_b24c_3e846fb83949
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:5476
initial concentration: NaN
constant: false
type: Species
name: CTSA
is: P10619
is: SBO:0000252

metaM aacoa x
constant: false
is: HMDB01484
type: Species
name: acetoacetyl-CoA(4-)
has only substance units: false
is: CHEBI:57286
is: SBO:0000247
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaM cs a deg4 l
constant: false
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 4
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57455
notes: FORMULA: C31H49NO29S CHARGE: -2
has only substance units: false
boundary condition: false
is: HMDB01354
type: Species
is: SBO:0000247

metaM taur c
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:3544
name: Taurine
is: C00245
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C2H7NO3S CHARGE: 0
constant: false
is: HMDB00251

http://identifiers.org/biomodels.db/MODEL1310110026#_5187471e_c06c_4a2f_ae78_b6450db958cd
type: Species
initial concentration: NaN
is encoded by: hsa:3291
name: HSD11B2
is: P80365
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_72fcfc7b_7ae0_48fe_b6e3_50f6bde5fdca
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:7378
name: UPP1

metaR r2320
kinetic law: MODEL1310110026#
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110026#
reactant: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR ILETAm
name: isoleucine transaminase, mitochondrial
kinetic law: MODEL1310110026#
is: SBO:0000176
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
product: MODEL1310110026#
reversible: true
fast: false
reactant: MODEL1310110026#
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.6.1.42
is described by: ECO:0000269
type: Reaction

metaM dolglcp U c
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:15812
initial amount: NaN
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog
type: Species
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
constant: false

metaM acgam l
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB00215
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
constant: false
is: CHEBI:17411
name: N-acetyl-D-glucosamine
has only substance units: false

metaR r0839
is: SBO:0000185
modifier: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110026#
reversible: true
is version of: http://identifiers.org/ec-code/1.3.1.70
name: Postulated transport reaction
fast: false
type: Reaction

metaR HOXG
name: Heme oxygenase 1
notes: GENE_ASSOCIATION: (3162.1) or (3163.1) SUBSYSTEM: Heme degradation EC Number: 1.14.99.3 Confidence Level: 0 AUTHORS: PMID:16356137 NOTES:TDV (4/28/2004) There are conflicting data on how many moles of NADPH consumed per mole of Biliverdine (Tenhunen 1969, Ryter, 2000). Heme oxygenase is a well known enzyme
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.14.99.3
fast: false
type: Reaction
reversible: false
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is: SBO:0000176
product: MODEL1310110026#
modifier: MODEL1310110026#

metaM sebcoa c
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
is: HMDB13325
type: Species
constant: false
name: sebacoylcoa
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaR DCSPTN1COAtx
product: MODEL1310110026#
fast: false
name: fatty acid intracellular transport
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reactant: MODEL1310110026#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110026#

metaM CE5786 e
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
is: SBO:0000247
name: kinetensin
initial concentration: 1.0
has only substance units: false
is: HMDB02710
is: CHEBI:27485
type: Species

metaR FTHFL
fast: false
kinetic law: MODEL1310110026#
reversible: true
is described by: ECO:0000134
product: MODEL1310110026#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.5
notes: GENE_ASSOCIATION: (4522.1) or (286297.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: Formate-tetrahydrofolate ligase
type: Reaction
modifier: MODEL1310110026#
reactant: MODEL1310110026#

metaR r2323
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
kinetic law: MODEL1310110026#
is: SBO:0000185
reactant: MODEL1310110026#
is described by: ECO:0000000
product: MODEL1310110026#
type: Reaction
fast: false

metaM trdox m
constant: false
initial concentration: 1.0
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
boundary condition: false
is: CHEBI:18191
has only substance units: false
type: Species
initial amount: NaN
name: Oxidized thioredoxin
is: SBO:0000247

metaR r0838
reactant: MODEL1310110026#
product: MODEL1310110026#
reversible: true
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
name: Free diffusion
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.2.4
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
fast: false
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110026#_62777760_f6bf_425a_acd8_cca695a61f6b
is encoded by: hsa:1329
has part: Q96KJ9
has part: Q7Z4L0
is encoded by: hsa:1340
has part: Q6YFQ2
is encoded by: hsa:9377
is encoded by: hsa:9167
is encoded by: hsa:341947
is encoded by: hsa:1349
has part: H0UI06
boundary condition: true
has part: P09669
has part: Q53YB7
is encoded by: hsa:4512
is encoded by: hsa:1350
type: Species
has part: P24311
has part: Q8TF08
has part: Q02221
constant: false
has part: Q6FGA0
is encoded by: hsa:4514
has only substance units: false
is encoded by: hsa:84701
is encoded by: hsa:1327
has part: Q7GXY8
initial concentration: NaN
is: SBO:0000297
has part: Q7GXZ8
has part: P20674
initial amount: NaN
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
is encoded by: hsa:1337
is encoded by: hsa:1346
has part: Q53XN1
has part: P24310
is encoded by: hsa:4513
is encoded by: hsa:1351
is encoded by: hsa:1347
has part: P13073
has part: P12074
has part: P15954
has part: P14854
is encoded by: hsa:170712
is encoded by: hsa:1339
is encoded by: hsa:125965
has part: P00414
is encoded by: hsa:1345

metaM lgnccoa x
is: HMDB06526
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C45H78N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H82N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h32-34,38-40,44,55-56H,4-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/t34-,38?,39-,40+,44-/m1/s1
type: Species
is: SBO:0000247
constant: false
name: lignocericyl coenzyme A
has only substance units: false

metaR MG2er
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
type: Reaction
is described by: ECO:0000000
product: MODEL1310110026#
is: SBO:0000176

metaR CERT1gt
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
modifier: MODEL1310110026#
reactant: MODEL1310110026#
is: SBO:0000185
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.7.11.1
fast: false
is described by: ECO:0000304
product: MODEL1310110026#
kinetic law: MODEL1310110026#
name: ceramide transport protein

http://identifiers.org/biomodels.db/MODEL1310110026#_415eeb28_9ea4_4fea_a821_ef37d6700c37
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: _AA629629_1_m
is encoded by: hsa:AA629629
boundary condition: true
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_536780ba_582d_4f56_a639_22054fde2ab1
is encoded by: hsa:223
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
is: P49189
constant: false
name: ALDH9A1

metaR BUTt2r
name: Butyrate transport via proton symport, reversible
fast: false
reversible: true
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
modifier: MODEL1310110026#
is: SBO:0000185
is described by: ECO:0000269
type: Reaction

metaM pheme m
is: SBO:0000247
type: Species
is: C00032
boundary condition: false
name: Protoheme
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
has only substance units: false
is: CHEBI:17627
is: HMDB03178

metaR r2322
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110026#
is: SBO:0000185
reactant: MODEL1310110026#
reversible: true
fast: false
product: MODEL1310110026#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110026#_3e97d67a_3428_4c3b_9d86_b8a98e21823b
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaR EX 10fthf6glu LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](6) exchange
type: Reaction

metaM dlnlcg e
is: SBO:0000247
is: HMDB02925
is: CHEBI:53486
boundary condition: false
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
initial amount: NaN
type: Species
name: dihomo-gamma-linolenic acid (n-6)
constant: false
has only substance units: false
initial concentration: 1.0

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

metaM c12dccoa c
initial concentration: 1.0
name: dodecanedioylcoa
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
type: Species
is: HMDB00623

metaM n2m2nm l
constant: false
is: HMDB00573
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
name: n2m2nmasn (w/o peptide linkage)
is: CHEBI:30825
type: Species
initial concentration: 1.0
notes: FORMULA: C58H97N5O41 CHARGE: 0

metaM HC01403 m
type: Species
has only substance units: false
is: CHEBI:28325
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
name: (S)-Hydroxydecanoyl-CoA
initial amount: NaN
is: SBO:0000247
constant: false

metaM retinal c
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15035
boundary condition: false
name: retinal
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
has only substance units: false
is: HMDB01358

metaM fuc1p L c
initial concentration: 1.0
is: HMDB01265
name: L-Fucose 1-phosphate
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C6H11O8P CHARGE: -2 INCHI: InChI=1S/C6H13O8P/c1-2-3(7)4(8)5(9)6(13-2)14-15(10,11)12/h2-9H,1H3,(H2,10,11,12)/t2-,3+,4+,5-,6?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01030
constant: false
initial amount: NaN
is: CHEBI:28319
type: Species

metaR C16DCc
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of hexadecanedioylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_813459a9_e780_4c44_876f_f7a7bb0eeb50
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:51227
is: SBO:0000252
type: Species
name: PIGP
is: P57054
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_467e6679_f46f_45c2_8dee_c6bc05a3fba7
is: Q14542
is: SBO:0000252
initial amount: NaN
name: SLC29A2
has only substance units: false
type: Species
is encoded by: hsa:3177
constant: false
initial concentration: NaN
boundary condition: true

metaR r2312
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
product: MODEL1310110026#
is: SBO:0000185
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: true

metaM aacoa c
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB01484
name: Acetoacetyl-CoA
initial amount: NaN
boundary condition: false
is: C00332
has only substance units: false
is: CHEBI:57286
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332

metaM fdp c
initial amount: NaN
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00300 EHMN_ABBREVIATION: C00354
is: CHEBI:16905
type: Species
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/3647
is: C00354
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB01058
name: D-Fructose 1,6-bisphosphate

metaM C05279 m
name: trans,cis-Lauro-2,6-dienoyl-CoA
boundary condition: false
is: HMDB11123
initial concentration: 1.0
initial amount: NaN
is: CHEBI:28387
type: Species
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279

metaR P5CDm
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.12
name: 1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
product: MODEL1310110026#
modifier: MODEL1310110026#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Glutamate metabolism EC Number: 1.5.1.12 Confidence Level: 4 AUTHORS: PMID:8621661,PMID:9700195 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
reversible: false

metaR r0321
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.5.2
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110026#
fast: false
reactant: MODEL1310110026#
modifier: MODEL1310110026#
product: MODEL1310110026#

metaR FUMTSULtm
modifier: MODEL1310110026#
reversible: true
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
name: Fumarate:thiosulfate antiport, mitochondrial
fast: false
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
type: Reaction
is described by: ECO:0000269
is: SBO:0000185

metaM pail4p hs c
is: CHEBI:58178
type: Species
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110026#_781506ae_81e1_4b0d_8f9b_ce76101b602c
name: SLC5A10
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:125206
is: A0PJK1
initial concentration: NaN
constant: false

metaR EX 4nph LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_d14945db_76a0_42f7_83be_1f4bef8000e7
initial amount: NaN
is encoded by: hsa:4830
boundary condition: true
constant: false
type: Species
has only substance units: false
name: NME1
is: P15531
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_a906ddb9_e269_4b49_97ff_3789890971f4
initial amount: NaN
is: Q9UBX8
boundary condition: true
name: B4GALT6
constant: false
is encoded by: hsa:9331
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_7936c2f5_0b8d_4565_b2dd_a47e5d314de5
initial concentration: NaN
boundary condition: true
constant: false
type: Species
name: _AI620219_1_c
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AI620219

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

metaR EX Lcystin LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Cystine exchange
type: Reaction

metaM orot e
initial concentration: 1.0
type: Species
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:30839
name: orotate
initial amount: NaN
is: HMDB00226
boundary condition: false

metaM 56dthm c
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
is: CHEBI:27468
type: Species
constant: false
is: HMDB00079
initial concentration: 1.0
name: 5,6-dihydrothymine

http://identifiers.org/biomodels.db/MODEL1310110026#_479c5f02_87f0_47db_af09_997cd52056c1
is: O75874
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3417
name: IDH1
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species

metaR EX 4hpro LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hydroxy proline
type: Reaction

metaR r1172
reversible: false
product: MODEL1310110026#
name: EC:3.1.1.13
fast: false
reactant: MODEL1310110026#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110026#

metaR r2313
type: Reaction
kinetic law: MODEL1310110026#
is: SBO:0000185
product: MODEL1310110026#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110026#
reversible: true
is described by: ECO:0000000

metaM nadph x
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: SBO:0000247
is: C00005
is: HMDB00221
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide phosphate - reduced
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:57783
constant: false
initial amount: NaN

metaR C16DCe
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Hexadecanedioic acid mono-L-carnitine ester into extra cellular space
type: Reaction

metaR DSAT
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ
reactant: MODEL1310110026#
is: SBO:0000176
name: dihydrosphingosine N-acyltransferase
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110026#
fast: false
product: MODEL1310110026#

metaM CE5125 x
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
has only substance units: false
name: (2S)-pristanoyl-CoA
is: HMDB00127
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/p-4/t26-,27-,28-,29-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5125
boundary condition: false
is: CHEBI:15748
initial concentration: 1.0

metaR ARGLYSex
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (9057.1 and 6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
is described by: ECO:0000269
name: Arginine/Lysine exchanger (Arg in)
is: SBO:0000185
modifier: MODEL1310110026#
fast: false
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
product: MODEL1310110026#

metaR SERGLYexR
fast: false
reversible: true
product: MODEL1310110026#
name: L-Serine/Glycine reversible exchange
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110026#
type: Reaction
reactant: MODEL1310110026#
modifier: MODEL1310110026#
is: SBO:0000185

metaM ppcoa x
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB01275
initial concentration: 1.0
is: C00100
type: Species
name: Propanoyl-CoA
boundary condition: false
is: CHEBI:57392
has only substance units: false

metaR PHCDm
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464,PMID:500817 NOTES:NCD
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000304
reversible: false
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.5.1.12
name: L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase
modifier: MODEL1310110026#
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#

metaR r2314
is: SBO:0000185
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110026#

metaM pail5p hs n
has only substance units: false
type: Species
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
initial amount: NaN
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
is: CHEBI:57795
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false

metaR r2100
is: SBO:0000185
product: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
fast: false
reactant: MODEL1310110026#
modifier: MODEL1310110026#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110026#_ce7af2a7_5203_4af7_ae78_8deb30f3ae7d
is: SBO:0000252
is: Q68CJ7
constant: false
boundary condition: true
name: UROC1
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:131669
initial concentration: NaN

metaR AG13T15g
fast: false
reactant: MODEL1310110026#
product: MODEL1310110026#
modifier: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110026#_c3194052_cb4f_44da_806b_22e7761a6582
initial amount: NaN
is encoded by: hsa:AI761708
initial concentration: NaN
name: _AI761708_1_m
boundary condition: true
constant: false
has only substance units: false
type: Species
is: SBO:0000252

metaM nm2masn g
has only substance units: false
type: Species
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
is: SBO:0000247
notes: FORMULA: C42H70N3O30X CHARGE: 0
is: C05884
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_f16cfe8a_0d41_4d82_a5a7_0be0aa36c4bd
is encoded by: hsa:5330
name: PLCB2
constant: false
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
is: Q59F77
initial amount: NaN
has only substance units: false

metaR SUCD1m
reversible: true
is version of: http://identifiers.org/ec-code/1.3.5.1
product: MODEL1310110026#
kinetic law: MODEL1310110026#
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
fast: false
is: SBO:0000176
modifier: MODEL1310110026#
name: succinate dehydrogenase
reactant: MODEL1310110026#

metaR DPCOAPPe
reversible: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
fast: false
product: MODEL1310110026#
name: Pyrophasphatase (dephospho-CoA, extracellular)

metaR HISTAtu
is described by: ECO:0000269
reactant: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
name: Histamine uniport
modifier: MODEL1310110026#
is: SBO:0000185
kinetic law: MODEL1310110026#
reversible: true
product: MODEL1310110026#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_c1cddc51_0fc2_4e89_952c_0d7d63f57c28
name: SLC27A1
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:376497
constant: false
has only substance units: false
type: Species

metaM urcan c
is: CHEBI:17771
initial amount: NaN
is: C00785
is: SBO:0000247
name: Urocanate
is: HMDB00301
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C6H5N2O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00534 EHMN_ABBREVIATION: C00785
has only substance units: false

metaR FACOAL244 1
modifier: MODEL1310110026#
is described by: ECO:0000000
product: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
name: fatty-acid--CoA ligase
reversible: true
fast: false
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110026#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110026#_e713bb41_ed66_4a70_898c_5596801412b2
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4540
initial concentration: NaN
name: ND5
type: Species
constant: false
is: P03915
initial amount: NaN
boundary condition: true

metaR NDPK3n
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000304
reversible: true
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
kinetic law: MODEL1310110026#
product: MODEL1310110026#
type: Reaction
reactant: MODEL1310110026#
name: nucleoside-diphosphate kinase (ATP:CDP),nuclear
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110026#_8270eb67_08dc_489e_b3b2_61a649c935f4
constant: false
has only substance units: false
boundary condition: true
name: _H17063_1_m
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:H17063
initial amount: NaN
type: Species

metaM CE2424 m
type: Species
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424
is: CHEBI:28387
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA
initial amount: NaN
initial concentration: 1.0
is: HMDB11123

metaR ARACHCRNt
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
type: Reaction
fast: false
is described by: ECO:0000000
name: transport into the mitochondria (carnitine)
product: MODEL1310110026#
is: SBO:0000185
reversible: false
modifier: MODEL1310110026#

metaR CAATPS
reversible: false
kinetic law: MODEL1310110026#
is: SBO:0000185
notes: GENE_ASSOCIATION: (492.1) or (491.1) or (490.1) or (493.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.6 Confidence Level: 4 AUTHORS: PMID:7876199,PMID:8396145 NOTES:plasma membrane version (SR and ER versions also exist) stoichiometry actually varies (number of Ca/ATP transported). See PMID: 7876199 NJ
fast: false
is described by: ECO:0000269
reactant: MODEL1310110026#
type: Reaction
name: Ca ATPase
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.6.3.8
product: MODEL1310110026#

metaM odecoa c
initial concentration: 1.0
name: Octadecenoyl-CoA (n-C18:1CoA)
constant: false
type: Species
is: SBO:0000247
is: CHEBI:3793
boundary condition: false
initial amount: NaN
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
has only substance units: false
is: HMDB01322

metaM pydam c
boundary condition: false
is: SBO:0000247
is: CHEBI:57761
name: Pyridoxamine
is: HMDB01431
initial concentration: 1.0
is: C00534
initial amount: NaN
notes: FORMULA: C8H13N2O2 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00416 EHMN_ABBREVIATION: C00534
constant: false
type: Species
has only substance units: false

metaR r2101
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
modifier: MODEL1310110026#
reversible: true
product: MODEL1310110026#
is described by: ECO:0000000
kinetic law: MODEL1310110026#
fast: false
reactant: MODEL1310110026#

metaR r2315
kinetic law: MODEL1310110026#
fast: false
product: MODEL1310110026#
reactant: MODEL1310110026#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000185

metaR CORE7GTg
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: O-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
fast: false
reactant: MODEL1310110026#
is: SBO:0000176
kinetic law: MODEL1310110026#
product: MODEL1310110026#
name: Core 7 alpha-GalNAc-transferase, Golgi apparatus
reversible: false
is described by: ECO:0000000

metaM strdnc c
name: stearidonic acid C18:4, n-3
boundary condition: false
is: C16300
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
is: http://identifiers.org/pubchem.compound/47205608
has only substance units: false
initial amount: NaN
is: HMDB06547
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110026#_e737de22_fcaa_480d_ad1e_9cde5a20e65b
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:D87002
boundary condition: true
initial amount: NaN
name: _D87002_1_e

metaM s7p c
initial amount: NaN
type: Species
name: Sedoheptulose 7-phosphate
constant: false
has only substance units: false
initial concentration: 1.0
is: C05382
is: HMDB01068
is: CHEBI:57483
boundary condition: false
is: SBO:0000247
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382

metaM lnlnca c
boundary condition: false
is: SBO:0000247
name: alpha-linolenate
constant: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
is: CHEBI:32387
is: HMDB01388
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false

metaR r2102
kinetic law: MODEL1310110026#
fast: false
type: Reaction
product: MODEL1310110026#
modifier: MODEL1310110026#
reactant: MODEL1310110026#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
is described by: ECO:0000000

metaR r2316
reactant: MODEL1310110026#
is: SBO:0000185
kinetic law: MODEL1310110026#
fast: false
reversible: true
product: MODEL1310110026#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR r1177
reactant: MODEL1310110026#
reversible: false
fast: false
type: Reaction
name: EC:3.1.1.13
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
kinetic law: MODEL1310110026#
product: MODEL1310110026#

metaM leuktrA4 c
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:57463
constant: false
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
initial concentration: 1.0
name: leukotriene A4(1-)
is: HMDB01337
is: SBO:0000247

metaR r1052
is: SBO:0000185
fast: false
name: Vesicular transport
reactant: MODEL1310110026#
is described by: ECO:0000000
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
reversible: false
product: MODEL1310110026#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_1cfa446e_c95f_4f78_a8e2_bfb47f316932
name: COQ2
has only substance units: false
constant: false
type: Species
is encoded by: hsa:27235
initial concentration: NaN
boundary condition: true
is: Q96H96
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_a9f856fd_a011_4d63_8698_cea18e49930b
has only substance units: false
is: O15245
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:6580
constant: false
initial amount: NaN
boundary condition: true
name: SLC22A1

http://identifiers.org/biomodels.db/MODEL1310110026#_7a6041a8_8ab7_4159_854c_f887d179824b
is: SBO:0000252
initial concentration: NaN
is: P22102
initial amount: NaN
is encoded by: hsa:2618
boundary condition: true
has only substance units: false
name: GART
constant: false
type: Species

metaR r2317
reversible: true
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
product: MODEL1310110026#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
is described by: ECO:0000000

metaM 44mzym r
is: HMDB01286
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:18364
initial concentration: 1.0
constant: false
name: 14-demethyllanosterol
is: SBO:0000247
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
initial amount: NaN

metaM acgam c
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
name: N-acetyl-D-glucosamine
is: CHEBI:17411
is: SBO:0000247
is: HMDB00215
boundary condition: false
type: Species

metaM strdnc e
has only substance units: false
is: HMDB06547
is: SBO:0000247
constant: false
name: stearidonic acid C18:4, n-3
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205608
initial concentration: 1.0
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
initial amount: NaN
is: C16300
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_c3e22457_72d6_4e3d_898c_e0b6eaa3b6c7
type: Species
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
name: NME1:NME2
is encoded by: hsa:4830
initial concentration: NaN
is: SBO:0000297

metaR r2103
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
modifier: MODEL1310110026#
reversible: true
kinetic law: MODEL1310110026#
fast: false
is described by: ECO:0000000
product: MODEL1310110026#
reactant: MODEL1310110026#

metaM trdox c
boundary condition: false
is: SBO:0000247
name: Oxidized thioredoxin
type: Species
is: C00343
is: CHEBI:18191
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343

metaR GLCt4
type: Reaction
reactant: MODEL1310110026#
name: glucose transport via sodium symport
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
modifier: MODEL1310110026#
is described by: ECO:0000269
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110026#
kinetic law: MODEL1310110026#

metaM lnlnca e
type: Species
is: HMDB01388
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:32387
name: alpha-linolenate
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-

metaM btcoa c
initial concentration: 1.0
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
name: Butanoyl-CoA
is: CHEBI:57371
is: C00136
initial amount: NaN
constant: false
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB01088

metaR r2318
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
type: Reaction
reactant: MODEL1310110026#
is described by: ECO:0000000
product: MODEL1310110026#
kinetic law: MODEL1310110026#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true

metaR SUCOASm
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110026#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.5
name: Succinate--CoA ligase (ADP-forming)
is version of: http://identifiers.org/ec-code/6.2.1.4
modifier: MODEL1310110026#
reactant: MODEL1310110026#
product: MODEL1310110026#
fast: false

metaM forglu c
initial amount: NaN
initial concentration: 1.0
is: HMDB00854
type: Species
name: N-Formimidoyl-L-glutamate
constant: false
notes: FORMULA: C6H8N2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00357 EHMN_ABBREVIATION: C00439
is: CHEBI:18327
has only substance units: false
is: SBO:0000247
is: C00439
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110026#_1d3fefb3_0669_4e63_b30d_c8e24942158a
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: ATG9B
boundary condition: true
is encoded by: hsa:285973
type: Species
has only substance units: false
constant: false
is: Q674R7

metaR CITtbm
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with PEP IF
type: Reaction
reversible: true
reactant: MODEL1310110026#
is described by: ECO:0000269
fast: false
is: SBO:0000185
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
product: MODEL1310110026#
name: citrate transport, mitochondrial

metaR r2104
kinetic law: MODEL1310110026#
type: Reaction
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is: SBO:0000185
modifier: MODEL1310110026#
is described by: ECO:0000000
reactant: MODEL1310110026#

metaR RE3243R
is described by: ECO:0000000
fast: false
product: MODEL1310110026#
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790,PMID:11567032,PMID:2114179 NOTES:
is: SBO:0000176
reactant: MODEL1310110026#
type: Reaction
name: RE3243
reversible: true

metaM leuktrA4 e
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:57463
constant: false
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
is: HMDB01337
initial concentration: 1.0
is: SBO:0000247
name: leukotriene A4(1-)

http://identifiers.org/biomodels.db/MODEL1310110026#_b3489356_3d67_4125_a283_c976ec103916
is encoded by: hsa:117248
initial concentration: NaN
initial amount: NaN
name: GALNTL2
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
is: Q8N3T1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_5ec51b94_f7a0_4e2d_ae92_e7be96de8b62
name: DGKZ
has only substance units: false
type: Species
constant: false
is: B7Z6M3
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:8525

metaR r1050
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
product: MODEL1310110026#
fast: false
kinetic law: MODEL1310110026#
name: Vesicular transport
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_bca5ba52_8522_4021_93b1_c01f0a440780
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: _AA526438_1_c
is encoded by: hsa:AA526438
initial concentration: NaN

metaR GLXtp
is: SBO:0000185
reactant: MODEL1310110026#
fast: false
product: MODEL1310110026#
kinetic law: MODEL1310110026#
name: glyoxylate transport, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
is described by: ECO:0000000
reversible: true
type: Reaction

metaR ASPPROASCT1
notes: GENE_ASSOCIATION: (6509.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14502423, PMID: 11824937, Kim E. Barrett, Mark Donowitz (2001) Gastrointestinal transport: Molecular physiology, Academic press, A harcourt science and technology company, chapter 10, pages 389-391. NOTES:ASCT-1 transport system operates at the basolateral surface, acts as an amino acid exchanger. Preferred substrates are small neutral amino acids, however shown to have transport proline and hydroxy-proline. At acidic ph also transports aspartate and glutamate. the ASCT-1 operates in a similar mechanism as ASCT-2.
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
product: MODEL1310110026#
type: Reaction
modifier: MODEL1310110026#
is: SBO:0000185
fast: false
is described by: ECO:0000134
reversible: false
name: aspartate intake by system ASCT-1 transporter

metaR EX tethex3 LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosahexaenoic acid, n-3 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_3b3c820f_0b92_4deb_ba2e_0636bda54f1f
is: Q9UFY1
constant: false
is encoded by: hsa:5335
name: PLCG1
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaM ksi deg40 l
is: CHEBI:12936
constant: false
initial amount: NaN
initial concentration: 1.0
name: keratan sulfate I, degradation product 40
boundary condition: false
notes: FORMULA: C40H68N2O31 CHARGE: 0
is: SBO:0000247
is: HMDB00143
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_2ec51502_9fba_465e_ae36_4c8792983f19
boundary condition: true
is: P56556
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4700
initial concentration: NaN
has only substance units: false
name: NDUFA6
type: Species
constant: false

metaR r2319
reactant: MODEL1310110026#
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110026#
kinetic law: MODEL1310110026#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

http://identifiers.org/biomodels.db/MODEL1310110026#_a5e7b6e9_9142_4d86_897c_6eb60c768c0b
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
type: Species
is: Q99519
initial amount: NaN
is encoded by: hsa:4758
has only substance units: false
name: NEU1

http://identifiers.org/biomodels.db/MODEL1310110026#_49b04ebb_7f27_4ead_a928_ba58f3692646
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
name: PANK2
is encoded by: hsa:80025
is: SBO:0000252
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_63a4b77c_6b01_4bc0_877e_50abbd3f4adc
type: Species
has only substance units: false
name: _AI915649_1_c
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:AI915649
initial concentration: NaN
initial amount: NaN

metaR r2105
type: Reaction
is: SBO:0000185
fast: false
reversible: true
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM pail3p hs c
type: Species
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C04549
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:58088
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
is: SBO:0000247
initial amount: NaN

metaR THD1m
reversible: true
is version of: http://identifiers.org/ec-code/1.6.1.2
notes: GENE_ASSOCIATION: (23530.2) or (23530.1) SUBSYSTEM: NAD metabolism EC Number: 1.6.1.2 Confidence Level: 4 AUTHORS: PMID:12223207,PMID:8647343,PMID:9524818 NOTES:TDV (2-6-2003)
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
fast: false
name: NAD(P) transhydrogenase
modifier: MODEL1310110026#
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
product: MODEL1310110026#

metaM orot c
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
is: C00295
name: Orotate
boundary condition: false
initial concentration: 1.0
is: CHEBI:30839
constant: false
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
is: HMDB00226

metaM dhcrm hs c
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:31488
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126
is: SBO:0000247
initial amount: NaN
name: dihydroceramide

metaR EX gtp LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GTP exchange
type: Reaction

metaM L2aadp c
name: L-2-aminoadipate(1-)
is: HMDB00510
boundary condition: false
is: SBO:0000247
is: CHEBI:58672
type: Species
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_61e65bfd_6ca1_4d38_ba64_2b0c00a0c602
boundary condition: true
is encoded by: hsa:55350
constant: false
initial amount: NaN
name: VNN3:VNN2:VNN1
is encoded by: hsa:8875
has part: O95498
has only substance units: false
is: SBO:0000297
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_61cff4e7_614d_486f_8b19_7f76f40a254c
initial amount: NaN
is encoded by: hsa:4258
initial concentration: NaN
is: SBO:0000252
constant: false
name: MGST2
boundary condition: true
has only substance units: false
is: D6RBB5
type: Species

metaR r0617
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110026#_a2531c96_9f6f_4b5d_a74c_ee4937d39e46
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:5211
is: Q7L2M7
is: SBO:0000252
boundary condition: true
name: PFKL
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_c7178533_b388_4d8d_80a0_251265f29620
name: ALPPL2
is: P10696
initial concentration: NaN
is encoded by: hsa:251
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110026#_82e8b9e7_5ec2_4122_a8c1_60d7e2451079
boundary condition: true
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:248
initial concentration: NaN
is: P09923
name: ALPI

http://identifiers.org/biomodels.db/MODEL1310110026#_5e86cba7_0d38_4510_94d7_ddeb425157bb
is: SBO:0000252
constant: false
is encoded by: hsa:10166
name: SLC25A15
has only substance units: false
boundary condition: true
is: Q9Y619
initial amount: NaN
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_8828cfa5_905b_414f_895a_bd7decc05d8c
is: Q8NFF2
name: SLC24A4
is encoded by: hsa:123041
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true

metaR MM8Ber
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, endoplasmic reticulum
fast: false
modifier: MODEL1310110026#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.2.1.113
kinetic law: MODEL1310110026#
reversible: false
type: Reaction
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (11253.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10409699,PMID:9592125 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110026#_48158052_5942_4c7b_852b_ddf28424ecd4
type: Species
boundary condition: true
initial concentration: NaN
name: HYAL3
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:8372
is: O43820
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_ff2101b0_5b39_47cd_a315_788951b59f55
is encoded by: hsa:513
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
name: ATP5D
is: SBO:0000252
type: Species
initial concentration: NaN

metaR EX ksii core2 LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 2-linked) exchange
type: Reaction

metaR GLXtm
kinetic law: MODEL1310110026#
product: MODEL1310110026#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110026#
name: glyoxylate transport, mitochondrial
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110026#_f6a1e0e0_0ed6_4d15_8f1e_9c9e11ee7e44
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
name: AMY1B
is encoded by: hsa:277
is: P04745
type: Species
initial amount: NaN

metaM ach n
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15355
is: SBO:0000247
has only substance units: false
type: Species
constant: false
is: HMDB00895
boundary condition: false
name: acetylcholine
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996

metaM L2aadp m
is: SBO:0000247
initial amount: NaN
is: HMDB00510
has only substance units: false
boundary condition: false
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
type: Species
initial concentration: 1.0
is: CHEBI:58672
name: L-2-aminoadipate(1-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_4a717fed_dff1_4bd5_865f_41f9807a8d90
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: ATP5J
type: Species
boundary condition: true
constant: false
is encoded by: hsa:522
is: SBO:0000252

metaM doldp U r
has only substance units: false
is: CHEBI:15750
type: Species
name: Dolichol diphosphate, human uterine homolog
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C1025H1670O70P20 CHARGE: -30 INCHI: InChI=1S/C25H46O7P2/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-31-34(29,30)32-33(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H,29,30)(H2,26,27,28)/b22-13+,23-15+,24-17-
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110026#_21110cd7_2e00_43d8_b989_171351f7b8a0
is: P00491
is encoded by: hsa:4860
boundary condition: true
has only substance units: false
initial amount: NaN
name: PNP
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false

metaR r0615
kinetic law: MODEL1310110026#
type: Reaction
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
reversible: true
is: SBO:0000176
modifier: MODEL1310110026#
is described by: ECO:0000000
reactant: MODEL1310110026#
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.3.1.168
notes: GENE_ASSOCIATION: (1629.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
fast: false

metaR ABTD
kinetic law: MODEL1310110026#
name: L-arabinitol 4-dehydrogenase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
reactant: MODEL1310110026#
is: SBO:0000176
fast: false
product: MODEL1310110026#
reversible: true
type: Reaction

metaM dcsptn1crn m
is: HMDB06321
initial amount: NaN
boundary condition: false
name: docosa-4,7,10,13,16-pentaenoyl carnitine
constant: false
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0

metaR r1179
fast: false
type: Reaction
product: MODEL1310110026#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
name: EC:3.1.1.13
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#

metaM ppi r
is: CHEBI:33019
has only substance units: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial concentration: 1.0
boundary condition: false
name: Diphosphate
initial amount: NaN
is: HMDB00250
constant: false
is: SBO:0000247
type: Species
is: C00013

http://identifiers.org/biomodels.db/MODEL1310110026#_8380bb87_4149_4a9b_87ba_5ac53162bb38
is: SBO:0000252
type: Species
initial concentration: NaN
name: _AI694761_1_c
has only substance units: false
is encoded by: hsa:AI694761
constant: false
boundary condition: true
initial amount: NaN

metaR METLEUex
kinetic law: MODEL1310110026#
is: SBO:0000185
name: Methionine/Leucine exchange (Met in)
notes: GENE_ASSOCIATION: (6520.1 and 8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
reactant: MODEL1310110026#
reversible: false
type: Reaction
is described by: ECO:0000269
product: MODEL1310110026#
modifier: MODEL1310110026#
fast: false

metaR r0616
fast: false
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
reversible: true
type: Reaction
kinetic law: MODEL1310110026#
is: SBO:0000176
product: MODEL1310110026#
is described by: ECO:0000000
reactant: MODEL1310110026#
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
modifier: MODEL1310110026#

metaM aacoa m
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB01484
boundary condition: false
initial amount: NaN
is: CHEBI:57286
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: SBO:0000247
constant: false
name: acetoacetyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110026#_975d2945_bd64_4e9e_9fbb_7f893d212a0b
is encoded by: hsa:4122
name: MAN2A2
has only substance units: false
is: Q9P1E4
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species

metaM c12dccoa x
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB03712
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
name: dodecanedioylcoa

metaR CSBPASEly
product: MODEL1310110026#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
reversible: false
name: chondroitin sulfate B proteoglycan protease, lysosome (endosome)

metaM glyc3p x
is: C00093
is: SBO:0000247
boundary condition: false
name: Glycerol 3-phosphate
initial concentration: 1.0
is: CHEBI:57597
type: Species
is: HMDB00126
constant: false
initial amount: NaN
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
has only substance units: false

metaR G14T20g
kinetic law: MODEL1310110026#
fast: false
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
product: MODEL1310110026#
is: SBO:0000176
is described by: ECO:0000000
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.38

http://identifiers.org/biomodels.db/MODEL1310110026#_8c457cef_5af5_43c4_aab2_21aaad71de9e
boundary condition: true
type: Species
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2954
initial amount: NaN
initial concentration: NaN
name: GSTZ1

metaM nadph r
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: C00005
is: HMDB00221
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:57783
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110026#_4368fe1e_b099_447b_9f00_0d74dd910260
is: P03897
name: ND3
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:4537
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false

metaR SEBACIDTD
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacic acid into cytosol (diffusion)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_09294b0a_dc02_4b6f_8fc4_f5ca0f0ca3ce
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: PTGIS
is: Q16647
has only substance units: false
type: Species
is encoded by: hsa:5740
constant: false
is: SBO:0000252

metaM hom L e
initial amount: NaN
has only substance units: false
name: L-homoserine
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
is: HMDB00719
boundary condition: false
constant: false
type: Species
is: CHEBI:15699
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110026#_bfb3b6c5_2056_4843_9764_aa1732b81817
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
has only substance units: false
is: P36542
initial concentration: NaN
name: ATP5C1
boundary condition: true
is encoded by: hsa:509

metaR FCLTm
product: MODEL1310110026#
reversible: false
fast: false
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (2235.1) or (2235.2) SUBSYSTEM: Heme synthesis EC Number: 4.99.1.1 Confidence Level: 2 AUTHORS: PMID:7983009 NOTES:NCD; r0096
type: Reaction
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/4.99.1.1
reactant: MODEL1310110026#
is: SBO:0000176
is described by: ECO:0000304
name: Ferrochelatase, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110026#_4fd16a11_660b_4f36_965f_6ecd097bf120
type: Species
is: O00443
has only substance units: false
name: PIK3C2A
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5286

metaR UMPK3n
name: UMP kinase (UTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
is: SBO:0000176
reversible: true
fast: false
is described by: ECO:0000269
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
product: MODEL1310110026#

metaR EX glygn4 LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})
type: Reaction

metaM ppi x
is: HMDB00250
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
is: C00013
name: Diphosphate
is: CHEBI:33019
initial concentration: 1.0
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013

metaM CE2435 m
constant: false
name: trans,cis-deca-2,4-dienoyl-CoA
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:57795
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435

http://identifiers.org/biomodels.db/MODEL1310110026#_71e41ba1_82cb_4938_8d2d_d24595cbc031
constant: false
initial concentration: NaN
name: NDUFS2
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is: B7Z792
is encoded by: hsa:4720

metaM odecoa m
is: CHEBI:57387
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: Octadecenoyl-CoA (n-C18:1CoA)
is: HMDB01322
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
is: SBO:0000247
has only substance units: false
type: Species

metaR PEROXx
type: Reaction
reversible: false
reactant: MODEL1310110026#
is: SBO:0000176
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (3295.1 and 8310.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:lumped peroxisomal alpha and beta oxidation pristanoyl-CoA -> 4,8 diemthylnonanoyl-CoA (result of compound not known) stoichiometry for O2 is questionable at present no fad in peroxisome - 1st step of beta ox is acyl-co oxidase (not reductase) NJ
is version of: http://identifiers.org/ec-code/4.2.1.107
name: peroxisomal lumped long chain fatty acid oxidation
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110026#
product: MODEL1310110026#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR r0614
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
type: Reaction
product: MODEL1310110026#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
is described by: ECO:0000000
reversible: true
fast: false

metaM udpgal g
initial amount: NaN
is: HMDB00302
boundary condition: false
name: UDP-D-galactose(2-)
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
initial concentration: 1.0
constant: false
is: CHEBI:58439
is: SBO:0000247
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_0c6e9aa3_de7b_42e8_94e7_ded2c95cea86
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:AW277253
name: _AW277253_1_c
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110026#_3f33965c_c764_4bc6_a5c0_331c9086f360
is encoded by: hsa:34
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
is: P11310
name: ACADM
initial concentration: NaN
constant: false

metaM pre prot r
name: glycophosphatidylinositol (GPI)-anchored protein precursor
type: Species
boundary condition: false
is: CHEBI:16240
notes: FORMULA: XY CHARGE: 0
initial amount: NaN
is: HMDB03125
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false

metaM HC02204 c
is: SBO:0000247
is: CHEBI:27624
has only substance units: false
name: prostaglandin-b1
type: Species
constant: false
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110026#_8dc4661e_536c_4393_b9fe_cefae23341cd
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000297
is encoded by: hsa:3939
constant: false
boundary condition: true
has part: P00338
type: Species
name: LDHA:LDHB

metaR PTDCACRNt
fast: false
is: SBO:0000185
name: pentadecanoate transport into the mitochondria
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ
type: Reaction
reversible: false
product: MODEL1310110026#
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000000
modifier: MODEL1310110026#

metaR 2HBt2
reversible: true
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
type: Reaction
is described by: ECO:0000269
name: 2-hydroxybutyrate cotransport with proton
fast: false
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
modifier: MODEL1310110026#
product: MODEL1310110026#
is: SBO:0000185

metaM hom L c
name: L-homoserine
is: SBO:0000247
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
initial amount: NaN
boundary condition: false
is: HMDB00719
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:15699
has only substance units: false

metaR URATEtx
reversible: false
product: MODEL1310110026#
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110026#
name: urate export from peroxisome
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000

metaR H8TAer
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (10026.1) and (8733.1) and (128869.1) and (94005.1) and (51604.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10727241,PMID:11483512,PMID:12802054,PMID:15632136,PMID:9356492,PMID:9468317 NOTES:EC 2.6.-.- NCD
reversible: false
name: H8 transamidase, endoplasmic reticulum
fast: false
is: SBO:0000176
product: MODEL1310110026#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_ec1a3a9a_4605_483d_bb10_4866dae436f0
initial amount: NaN
is encoded by: hsa:5283
type: Species
is: SBO:0000252
is: Q14442
has only substance units: false
boundary condition: true
initial concentration: NaN
name: PIGH
constant: false

metaM pail4p hs n
initial concentration: 1.0
boundary condition: false
type: Species
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
initial amount: NaN
is: CHEBI:58178

metaM frdp x
is: CHEBI:175763
is: HMDB00961
has only substance units: false
name: farnesyl pyrophosphate(3-)
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_a371da9f_b75b_4090_8c9d_3d53a7c7716e
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:T83654
name: _T83654_1_e
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110026#_3b1bf770_ec81_44f2_a790_f37df0d17a78
is encoded by: hsa:9152
has only substance units: false
type: Species
constant: false
name: SLC6A5
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q9Y345

http://identifiers.org/biomodels.db/MODEL1310110026#_9cc38f2e_e983_4037_822b_6bae36c41844
is: SBO:0000252
is: Q9NSW9
initial concentration: NaN
name: SLC9A5
type: Species
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:6553

metaR BACCL
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.4.10
modifier: MODEL1310110026#
product: MODEL1310110026#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
kinetic law: MODEL1310110026#
reversible: false
fast: false
name: biotin-[acetyl-CoA-carboxylase] ligase
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_2ba0b469_0e1a_4ea6_b7e5_c09e4ed09258
type: Species
is: SBO:0000252
is encoded by: hsa:8534
initial concentration: NaN
name: CHST1
constant: false
boundary condition: true
is: O43916
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_9affef8d_c25d_4c87_8d9b_f8c7393b40b6
is encoded by: hsa:9123
constant: false
name: SLC16A3
is: O15427
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaM acgam6p c
is: CHEBI:57513
name: N-acetyl-D-glucosamine 6-phosphate(2-)
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
type: Species
constant: false
boundary condition: false
is: HMDB01062
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaM HC01223 m
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:57340
constant: false
type: Species
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
initial amount: NaN
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)

metaM ile L e
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
initial amount: NaN
is: HMDB00172
name: L-isoleucine
boundary condition: false
has only substance units: false
is: CHEBI:17191
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false

metaM val L m
initial concentration: 1.0
type: Species
initial amount: NaN
name: L-valine
constant: false
is: SBO:0000247
is: CHEBI:16414
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: HMDB00883
has only substance units: false
boundary condition: false

metaR THBPT4ACAMDASE
kinetic law: MODEL1310110026#
is: SBO:0000176
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/4.2.1.96
reactant: MODEL1310110026#
modifier: MODEL1310110026#
reversible: false
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
fast: false
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
is described by: ECO:0000269
type: Reaction

metaM nadph m
is: C00005
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB00221
is: CHEBI:57783
constant: false
type: Species
name: Nicotinamide adenine dinucleotide phosphate - reduced
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
initial concentration: 1.0

metaM ppi m
is: HMDB00250
initial amount: NaN
boundary condition: false
constant: false
name: Diphosphate
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: SBO:0000247
is: C00013
initial concentration: 1.0
is: CHEBI:33019
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_d441f1de_e22a_410b_8f01_db0cea206e49
type: Species
initial concentration: NaN
boundary condition: true
is: O60760
name: HPGDS
is: SBO:0000252
is encoded by: hsa:27306
has only substance units: false
constant: false
initial amount: NaN

metaM co2 r
initial amount: NaN
type: Species
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
name: CO2
is: C00011
is: HMDB01967
initial concentration: 1.0
is: CHEBI:16526
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_2f383379_dec6_4ba3_8816_ff0bbbff073c
is: SBO:0000252
is encoded by: hsa:NM 001929
name: _NM_001929_1_c
type: Species
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_16c76812_b2fc_43ab_9fcc_e54c0f37c387
has only substance units: false
is: SBO:0000252
is encoded by: hsa:80025
constant: false
boundary condition: true
name: PANK2
initial amount: NaN
type: Species
initial concentration: NaN

metaR r0842
fast: false
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.3.1.72
kinetic law: MODEL1310110026#
name: Postulated transport reaction
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
product: MODEL1310110026#
modifier: MODEL1310110026#
type: Reaction
reactant: MODEL1310110026#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110026#_03b39d72_7d6b_45e9_9920_995f5413deb7
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:10195
constant: false
name: ALG3
type: Species

metaR EX pydxn LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Pyridoxine
type: Reaction

metaM ppi n
name: diphosphate(3-)
type: Species
has only substance units: false
boundary condition: false
is: HMDB00250
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: SBO:0000247
is: CHEBI:33019

metaM ksii core4 g
is: HMDB01014
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
has only substance units: false
is: CHEBI:57255
initial concentration: 1.0
boundary condition: false
name: keratan sulfate II (core 4-linked)
type: Species

metaR PAPtg
name: adenosine 3',5'-bisphosphate Golgi transport
fast: false
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110026#
product: MODEL1310110026#
is: SBO:0000185
type: Reaction

metaR r0841
modifier: MODEL1310110026#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.271
kinetic law: MODEL1310110026#
reversible: true
is described by: ECO:0000000
product: MODEL1310110026#
reactant: MODEL1310110026#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16756494 NOTES:
name: Free diffusion

metaM triodthy e
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
boundary condition: false
type: Species
name: 3,3',5-triiodo-L-thyronine
is: HMDB00265
is: CHEBI:18258

metaR EX ncam LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinamide exchange
type: Reaction

metaR BACCLm
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
is described by: ECO:0000254
type: Reaction
name: biotin-[acetyl-CoA-carboxylase] ligase, mitochondrial
fast: false
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 2 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
is: SBO:0000176
reversible: false
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/6.3.4.10
product: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_20e7bb55_6847_4615_bcb3_59df2091fdaf
name: DLAT
has only substance units: false
is: Q86YI5
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:1737
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaM ksi pre20 g
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 20
notes: FORMULA: C171H274N12O140S6X CHARGE: -7
boundary condition: false
is: CHEBI:28067
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_bdaf8ed2_fc65_4da3_a783_87c02e0c1771
initial amount: NaN
initial concentration: NaN
is: A8K7W0
name: VNN2
is encoded by: hsa:8875
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
type: Species

metaR DRPA
is described by: ECO:0000000
reactant: MODEL1310110026#
fast: false
reversible: false
type: Reaction
product: MODEL1310110026#
name: deoxyribose-phosphate aldolase
is: SBO:0000176
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:

metaR ADRNt
type: Reaction
product: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
is: SBO:0000185
fast: false
is described by: ECO:0000000
reactant: MODEL1310110026#

metaM ksi pre36 g
type: Species
notes: FORMULA: C247H394N17O210S11X CHARGE: -12
boundary condition: false
initial amount: NaN
constant: false
name: keratan sulfate I biosynthesis, precursor 36
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:28067

metaR HMGLm
fast: false
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (3155.1) or (54511.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11129331 NOTES:TV
is described by: ECO:0000134
modifier: MODEL1310110026#
name: hydroxymethylglutaryl-CoA lyase
kinetic law: MODEL1310110026#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.3.4
product: MODEL1310110026#
type: Reaction

metaM didp n
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
is: CHEBI:28823
type: Species
is: SBO:0000247
name: dIDP
is: HMDB03536
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN

metaM ksi deg32 l
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C82H135N5O67S2 CHARGE: -2
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: keratan sulfate I, degradation product 32
is: CHEBI:12936
type: Species
is: HMDB00143

http://identifiers.org/biomodels.db/MODEL1310110026#_2acd2bad_726e_4087_9f53_d88fbc542abe
constant: false
name: MTHFD1
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:4522
initial concentration: NaN
is: P11586
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_5be26662_ebbf_4bdf_86a6_03a79cb66486
is: SBO:0000252
name: NDUFA10
is encoded by: hsa:4705
constant: false
initial concentration: NaN
is: O95299
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true

metaM dtmp e
is: CHEBI:26999
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: dTMP(2-)
type: Species
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
is: HMDB01227

http://identifiers.org/biomodels.db/MODEL1310110026#_3f2289dc_44b1_4d53_ac65_b0a1fc329ab8
is encoded by: hsa:4329
boundary condition: true
name: ALDH6A1
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
is: Q02252
type: Species

metaR GLYC St
product: MODEL1310110026#
reversible: false
is: SBO:0000185
type: Reaction
name: L-glycerate export
is described by: ECO:0000000
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:9604805 NOTES:
fast: false

metaM ksii core4 e
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
has only substance units: false
is: HMDB00211
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:17268
name: keratan sulfate II (core 4-linked)
initial concentration: 1.0
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_e5f4cf03_3605_4fbf_8103_bfac40f79886
has only substance units: false
is encoded by: hsa:5805
is: SBO:0000252
name: PTS
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is: Q03393

http://identifiers.org/biomodels.db/MODEL1310110026#_593ac275_c005_4e17_ac31_4a09a3084727
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
is: Q15067
is encoded by: hsa:51
type: Species
name: ACOX1
initial concentration: NaN
initial amount: NaN

metaM grdp x
is: HMDB01285
notes: FORMULA: C10H17O7P2 CHARGE: -3 INCHI: InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/p-3/b10-7+ HEPATONET_1.0_ABBREVIATION: HC00288 EHMN_ABBREVIATION: C00341
has only substance units: false
is: SBO:0000247
is: CHEBI:58057
name: geranyl diphosphate(3-)
boundary condition: false
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0

metaM triodthy c
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
name: 3,3',5-triiodo-L-thyronine
boundary condition: false
constant: false
type: Species
is: CHEBI:18258
is: HMDB00265

metaM HC00900 c
name: Methylmalonate
is: CHEBI:30860
constant: false
type: Species
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_a11e6046_1a65_4293_bed6_b8818a75f70d
is: B3KXN9
constant: false
initial amount: NaN
is encoded by: hsa:84890
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: ADO
has only substance units: false

metaR It
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
fast: false
kinetic law: MODEL1310110026#
is: SBO:0000185
modifier: MODEL1310110026#
name: Iodide uniport
product: MODEL1310110026#
is described by: ECO:0000269
reactant: MODEL1310110026#

metaR DESAT18 7
product: MODEL1310110026#
modifier: MODEL1310110026#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
kinetic law: MODEL1310110026#
reversible: false
name: fatty acyl-CoA desaturase (n-C18:1CoA -> n-C18:2CoA)
fast: false
reactant: MODEL1310110026#
type: Reaction

metaR EX co LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Carbon monoxide exchange
type: Reaction

metaM dgdp c
type: Species
is: CHEBI:58595
is: SBO:0000247
is: C00361
constant: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB00960
name: dGDP

metaR FAEL205
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
reactant: MODEL1310110026#
name: fatty-acyl-CoA elongation (n-C20:5CoA)
is described by: ECO:0000000
modifier: MODEL1310110026#
reversible: false
kinetic law: MODEL1310110026#
type: Reaction
product: MODEL1310110026#
is: SBO:0000176
fast: false

metaM o2 x
constant: false
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
is: C00007
initial concentration: 1.0
name: O2
initial amount: NaN
is: HMDB01377
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: CHEBI:15379

metaM camp c
name: 3',5'-cyclic AMP(1-)
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:58165
is: HMDB00058
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C10H11N5O6P CHARGE: -1 INCHI: InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/p-1/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00434 EHMN_ABBREVIATION: C00575

metaM bildglcur e
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB03325
is: CHEBI:58471
name: bis(beta-glucosyluronate)bilirubin
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
initial concentration: 1.0

metaM ptdcacrn c
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:15811
is: HMDB01721
has only substance units: false
notes: FORMULA: C22H43NO4 CHARGE: 0 INCHI: InChI=1/C22H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)27-20(18-21(24)25)19-23(2,3)4/h20H,5-19H2,1-4H3/t20-/m0/s1
name: pendtadenoyl carnitine
type: Species
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_62b06677_6ec4_4112_95f7_95847d81ca48
has only substance units: false
is encoded by: hsa:AA021081
boundary condition: true
name: _AA021081_1_r
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
initial amount: NaN

metaM gthrd r
constant: false
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: SBO:0000247
has only substance units: false
is: CHEBI:57925
initial amount: NaN
type: Species
initial concentration: 1.0
name: glutathionate(1-)
is: HMDB00125
boundary condition: false

metaM tcynt m
is: CHEBI:18022
has only substance units: false
type: Species
constant: false
name: thiocyanate
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
is: HMDB01453
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110026#_ba1bf85f_e25f_4ad1_b91b_381833d97b4b
is: SBO:0000252
type: Species
initial amount: NaN
name: COX7C
is: P15954
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:1350
initial concentration: NaN

metaR FAOXC2242046x
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
kinetic law: MODEL1310110026#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 3295.1 and 30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c22:4,n-6 -> c20:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110026#
name: Beta oxidation of long chain fatty acid
product: MODEL1310110026#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR XOLTRIOLtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
kinetic law: MODEL1310110026#
fast: false
product: MODEL1310110026#
is: SBO:0000185
reversible: true
name: lipid, flip-flop intracellular transport
reactant: MODEL1310110026#
type: Reaction
is described by: ECO:0000000

metaM pydx5p e
initial amount: NaN
is: SBO:0000247
name: pyridoxal 5'-phosphate(2-)
initial concentration: 1.0
is: CHEBI:597326
type: Species
is: HMDB01491
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C8H8NO6P CHARGE: -2 INCHI: InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)/p-2 HEPATONET_1.0_ABBREVIATION: HC00028 EHMN_ABBREVIATION: C00018

metaR r0845
is described by: ECO:0000000
reactant: MODEL1310110026#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110026#
reversible: false
type: Reaction
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12759756,PMID:17466261,PMID:9759482 NOTES:UGLCNACtg but different compartment
name: Drug/Metabolite Transporter (DMT) TCDB:2.A.7.12.7

metaR 5ADTSTSTERONEte
name: 5 alpha dihydrotesterone transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
product: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110026#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110026#_ece91060_41a3_4644_81b5_e0db847c019e
is encoded by: hsa:10195
is: Q92685
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
constant: false
name: ALG3
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110026#_e6171869_6407_4420_8aae_f208118f925f
type: Species
is: SBO:0000252
name: MTMR3
is encoded by: hsa:8897
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false

metaR GLCter
reactant: MODEL1310110026#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD
name: glucose transport, endoplasmic reticulum
reversible: true
is described by: ECO:0000000
product: MODEL1310110026#
kinetic law: MODEL1310110026#
fast: false

metaR r0512
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
is version of: http://identifiers.org/ec-code/1.17.4.1
product: MODEL1310110026#
is: SBO:0000176
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
reversible: true
fast: false
reactant: MODEL1310110026#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110026#

metaM dcyt n
is: SBO:0000247
is: HMDB00014
initial concentration: 1.0
is: CHEBI:15698
has only substance units: false
boundary condition: false
name: 2'-deoxycytidine
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881

http://identifiers.org/biomodels.db/MODEL1310110026#_a2f97948_0876_42e3_8e52_5a49b44d0760
initial amount: NaN
type: Species
is encoded by: hsa:3906
is: SBO:0000297
boundary condition: true
has part: P00709
has only substance units: false
constant: false
initial concentration: NaN
name: B4GALT1:LALBA

http://identifiers.org/biomodels.db/MODEL1310110026#_2438d1e6_a5f7_49f7_92a7_e48cba80a6a9
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is: P23743
is encoded by: hsa:1606
name: DGKA

http://identifiers.org/biomodels.db/MODEL1310110026#_7cff2209_edc7_4028_a4e0_3cedbfa06d47
initial amount: NaN
is: SBO:0000252
type: Species
name: ME2
is: P23368
has only substance units: false
constant: false
is encoded by: hsa:4200
boundary condition: true
initial concentration: NaN

metaR DCSPTN1t
is: SBO:0000185
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
is described by: ECO:0000000
name: fatty acid transport via diffusion
fast: false
type: Reaction

metaM bildglcur c
initial amount: NaN
has only substance units: false
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
is: CHEBI:58471
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
name: bis(beta-glucosyluronate)bilirubin
is: HMDB03325

metaM co2 x
boundary condition: false
constant: false
is: CHEBI:16526
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01967
type: Species
initial amount: NaN
notes: FORMULA: CO2 CHARGE: 0 INCHI: InChI=1S/CO2/c2-1-3 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
name: carbon dioxide

http://identifiers.org/biomodels.db/MODEL1310110026#_870e22ca_73ba_4e5f_923c_3c508cb2a1a8
is encoded by: hsa:26289
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
name: AK5

http://identifiers.org/biomodels.db/MODEL1310110026#_ffa33ea3_3082_453c_a114_f394555619c2
boundary condition: true
name: CRAT
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:1384
has only substance units: false

metaM mmcoa S m
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13+,16+,17+,18-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00495
initial concentration: 1.0
is: HMDB02310
type: Species
is: CHEBI:57327
boundary condition: false
name: (S)-methylmalonyl-CoA(5-)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110026#_c5397c74_3f83_4f33_9792_ca995efeb5d2
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:53354
initial amount: NaN
name: PANK1
is: SBO:0000252

metaR P4508B11r
is: SBO:0000176
name: sterol 12-alpha-hydroxylase
is described by: ECO:0000269
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
reversible: false
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.13.95
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (1582.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH and NADPH can both be used)
modifier: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_45476493_6801_4a69_bbf7_3f9643a7cca9
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5137
constant: false
initial concentration: NaN
name: PDE1C
has only substance units: false
type: Species
boundary condition: true
is: Q8NB10

http://identifiers.org/biomodels.db/MODEL1310110026#_84081086_92b4_46c6_921a_ca495dcbdeb2
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
type: Species
name: SOD1
is: P00441
has only substance units: false
initial amount: NaN
is encoded by: hsa:6647

metaM pydx5p c
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:597326
type: Species
is: C00018
is: HMDB01491
name: Pyridoxal 5'-phosphate
notes: FORMULA: C8H8NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00028 EHMN_ABBREVIATION: C00018
boundary condition: false
constant: false

metaM s2l2n2m2masn e
type: Species
initial concentration: 1.0
is: CHEBI:3554
notes: FORMULA: C84H135N6O61X CHARGE: -2
is: HMDB00244
constant: false
name: de-Fuc form of PA6
boundary condition: false
is: SBO:0000247
is: C00255
has only substance units: false
initial amount: NaN

metaM dgtp n
is: SBO:0000247
boundary condition: false
is: HMDB01440
has only substance units: false
constant: false
is: C00286
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
initial concentration: 1.0
is: CHEBI:16497
type: Species
name: dGTP
initial amount: NaN

metaR BILIRUBt2
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
type: Reaction
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
is described by: ECO:0000269
fast: false
reactant: MODEL1310110026#
reversible: true
name: bilirubin transport via bicarbonate countertransport
product: MODEL1310110026#
is: SBO:0000185

metaM acald m
is: HMDB00990
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
name: acetaldehyde
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:15343

http://identifiers.org/biomodels.db/MODEL1310110026#_b179a849_ef39_4b9b_87ad_242d4c754bb0
type: Species
initial amount: NaN
is: SBO:0000252
is: Q02218
name: OGDH
constant: false
boundary condition: true
is encoded by: hsa:4967
initial concentration: NaN
has only substance units: false

metaM m4mpdol U c
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
constant: false
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial amount: NaN
is: SBO:0000247
is: CHEBI:37633

http://identifiers.org/biomodels.db/MODEL1310110026#_a20e019f_0a51_412d_b558_1f56756bc19a
has only substance units: false
constant: false
initial concentration: NaN
name: PKLR
boundary condition: true
type: Species
initial amount: NaN
is: P30613
is: SBO:0000252
is encoded by: hsa:5313

metaM ppi e
initial concentration: 1.0
boundary condition: false
is: CHEBI:33019
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: C00013
initial amount: NaN
constant: false
name: Diphosphate
is: HMDB00250

http://identifiers.org/biomodels.db/MODEL1310110026#_940ef0e4_69c6_4b63_8d8b_a60ce666469e
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:AI926493
is: SBO:0000252
name: _AI926493_1_m

http://identifiers.org/biomodels.db/MODEL1310110026#_25b34eb8_bce0_4d3a_afff_4b0294090ab9
constant: false
has only substance units: false
is: A8K3J4
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
name: CA14
is encoded by: hsa:23632
initial concentration: NaN

metaM s2l2n2m2masn l
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:18287
notes: FORMULA: C84H135N6O61X CHARGE: -2
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: de-Fuc form of PA6
is: HMDB00174

metaR r2311
reversible: true
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
product: MODEL1310110026#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

metaR NTD10
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.5
reactant: MODEL1310110026#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110026#
product: MODEL1310110026#
name: 5'-nucleotidase (XMP)
reversible: false
modifier: MODEL1310110026#
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:15699053 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31. Rat

metaM val L e
has only substance units: false
is: CHEBI:16414
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
name: L-valine
initial amount: NaN
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: HMDB00883

metaM mthgxl e
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: methylglyoxal
has only substance units: false
is: CHEBI:17158
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
type: Species
constant: false
is: HMDB01167
initial concentration: 1.0

metaM L2aadp6sa m
is: HMDB01263
boundary condition: false
has only substance units: false
is: CHEBI:17917
name: L-allysine
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
initial concentration: 1.0

metaM 4mlacac c
constant: false
name: 4-maleylacetoacetate
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1- HEPATONET_1.0_ABBREVIATION: HC00635 EHMN_ABBREVIATION: C01036
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB02052
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17105

metaM nadph c
is: C00005
constant: false
type: Species
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: SBO:0000247
is: CHEBI:57783
boundary condition: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
has only substance units: false
is: HMDB00221
initial amount: NaN

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_b8c0b01c_f9a7_4ab2_95b2_3e47f3941691
type: Species
is encoded by: hsa:4539
boundary condition: true
initial concentration: NaN
is: Q7GXZ4
name: ND4L
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false

metaR CHAT
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110026#
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.3.1.6
name: Choline O-acetyltransferase
is described by: ECO:0000269
fast: false
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
reactant: MODEL1310110026#
reversible: true

metaR PGLer
is: SBO:0000176
reactant: MODEL1310110026#
reversible: false
fast: false
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.1.1.47
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 3.1.1.31 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:SMP Net reaction same as described in Lehringer 334 NCD
product: MODEL1310110026#
type: Reaction
modifier: MODEL1310110026#
name: 6-phosphogluconolactonase, endoplasmic reticulum

metaR H6 ETer
is described by: ECO:0000000
product: MODEL1310110026#
name: H6' phosphoethanolaminyl transferase, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10574991 NOTES:NCD
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
reversible: false

metaR IDPtn
name: IDP nuclear transport
is: SBO:0000185
reversible: true
product: MODEL1310110026#
fast: false
kinetic law: MODEL1310110026#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction
reactant: MODEL1310110026#

metaM tmndnccoa m
is: HMDB06514
name: timnodonyl coenzyme A
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
constant: false
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false

metaM cs e l
constant: false
notes: FORMULA: C45H64N2O55S6 CHARGE: -8
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:36005
type: Species
boundary condition: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), free chain
is: HMDB02183
has only substance units: false
initial amount: NaN

metaM icit x
is: SBO:0000247
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
is: HMDB00193
is: CHEBI:16087
has only substance units: false
initial amount: NaN
name: isocitrate(3-)
constant: false
type: Species
boundary condition: false
initial concentration: 1.0

metaM ksii core4 l
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
is: HMDB01014
constant: false
initial concentration: 1.0
name: keratan sulfate II (core 4-linked)
boundary condition: false
is: CHEBI:57255
notes: FORMULA: C89H142N7O72S3X CHARGE: -4

metaR r0731
fast: false
product: MODEL1310110026#
is: SBO:0000176
reactant: MODEL1310110026#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110026#
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17

metaM ptdcacrn m
notes: FORMULA: C22H43NO4 CHARGE: 0 INCHI: InChI=1/C22H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)27-20(18-21(24)25)19-23(2,3)4/h20H,5-19H2,1-4H3/t20-/m0/s1
is: HMDB01721
name: pendtadenoyl carnitine
type: Species
is: CHEBI:15811
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_29a336ce_13d2_4cb6_962a_a227c382ff63
has part: Q9UHI5
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000297
constant: false
type: Species
name: SLC7A8:SLC3A2
is encoded by: hsa:23428
initial concentration: NaN

metaR FATP9t
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
type: Reaction
modifier: MODEL1310110026#
name: fatty acid electroneutral transport
is described by: ECO:0000269
kinetic law: MODEL1310110026#
reversible: true
is: SBO:0000185
is version of: http://identifiers.org/ec-code/6.2.1.7
reactant: MODEL1310110026#

metaR 3SALATAim
name: 3-sulfino-alanine transaminase (irreversible), mitochondrial
kinetic law: MODEL1310110026#
is: SBO:0000176
fast: false
modifier: MODEL1310110026#
reversible: false
is described by: ECO:0000304
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM. activity measured in rat, 3-sulfinoalanine is substrate found in human brain
type: Reaction
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.6.1.1

http://identifiers.org/biomodels.db/MODEL1310110026#_36998298_caeb_4c42_8e05_eb8325c93fdb
is: SBO:0000297
has only substance units: false
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:515
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
initial concentration: NaN
boundary condition: true

metaR AG13T4g
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110026#
type: Reaction
fast: false
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (10331.1) or (374907.1) or (146712.1) or (374907.2) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110026#
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_06dbea18_8d94_4bb3_8058_1198a895c111
initial concentration: NaN
boundary condition: true
is: Q9Y4C5
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:9435
initial amount: NaN
name: CHST2
constant: false

metaM c3dc e
boundary condition: false
notes: FORMULA: C10H16NO6 CHARGE: -1
is: HMDB02095
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: malonyl carnitine
constant: false

metaM val L c
is: HMDB00883
is: CHEBI:16414
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
name: L-valine
constant: false
initial amount: NaN
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
has only substance units: false

metaM mthgxl c
name: methylglyoxal
type: Species
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:17158
is: HMDB01167
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110026#_6f68b9d9_dbd2_4322_a61e_8296bb68d66f
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2618
has only substance units: false
boundary condition: true
name: GART
initial concentration: NaN
type: Species
constant: false
is: Q59HH3

metaR C16OHc
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyhexadecanoylcarnitinec
type: Reaction

metaM CE0233 c
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
name: 5beta-cholestane-3alpha,7alpha,27-triol
initial amount: NaN
is: HMDB01993
is: CHEBI:17899
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1/C27H48O3/c1-17(7-6-12-25(2,3)30)20-8-9-21-24-22(11-14-27(20,21)5)26(4)13-10-19(28)15-18(26)16-23(24)29/h17-24,28-30H,6-16H2,1-5H3/t17-,18-,19+,20-,21-,22-,23+,24-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE0233
boundary condition: false

metaR HXPRT
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
is described by: ECO:0000269
reversible: false
name: hypoxanthine phosphoribosyltransferase (Hypoxanthine)
reactant: MODEL1310110026#
type: Reaction
fast: false
product: MODEL1310110026#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.8
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine (see GUAPRT) and 6-mercaptopurine can replace hypoxanthine

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_796f1750_f32d_4ccd_9c08_1395465aa359
constant: false
initial amount: NaN
is: B7Z3U6
has only substance units: false
type: Species
name: ATP1A1
boundary condition: true
initial concentration: NaN
is encoded by: hsa:476
is: SBO:0000252

metaR r0730
is: SBO:0000176
product: MODEL1310110026#
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
fast: false
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reversible: false
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_3b6d97a3_d48d_4ad8_9767_8348087a4004
is encoded by: hsa:4700
boundary condition: true
type: Species
initial amount: NaN
name: NDUFA6
has only substance units: false
initial concentration: NaN
constant: false
is: P56556
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110026#_5a98c06e_e018_4ce1_9e9a_be4825f38d3c
type: Species
is encoded by: hsa:6718
constant: false
initial amount: NaN
initial concentration: NaN
is: P51857
is: SBO:0000252
has only substance units: false
boundary condition: true
name: AKR1D1

metaR CO2t
is: SBO:0000185
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
name: CO2 transporter via diffusion
product: MODEL1310110026#
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD

metaR C14STRr
is described by: ECO:0000134
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
is: SBO:0000176
name: C-14 sterol reductase
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
is version of: http://identifiers.org/ec-code/1.3.1.70
product: MODEL1310110026#
fast: false
modifier: MODEL1310110026#
reversible: false
type: Reaction

metaR GLYt2r
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
modifier: MODEL1310110026#
is described by: ECO:0000304
fast: false
product: MODEL1310110026#
reactant: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
name: glycine reversible transport via proton symport
reversible: true
is: SBO:0000185

metaM hmgcoa x
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
is: SBO:0000247
is: CHEBI:15467
is: HMDB01375
name: Hydroxymethylglutaryl-CoA
has only substance units: false
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaM dodecanac x
notes: FORMULA: C12H20O4 CHARGE: -2
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB00623
name: Dodecanedioic acid

metaR GCC2cm
type: Reaction
is described by: ECO:0000269
reversible: true
is version of: http://identifiers.org/ec-code/1.4.4.2
product: MODEL1310110026#
fast: false
is: SBO:0000176
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.8.1.4
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
name: glycine-cleavage complex (lipoamide), mitochondrial
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.1.2.10

metaR O2tm
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
product: MODEL1310110026#
is: SBO:0000185
fast: false
type: Reaction
name: O2 transport (diffusion)
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110026#_371e18bb_7689_4eed_9f22_fed4996fe908
is: SBO:0000297
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
is encoded by: hsa:518
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
constant: false

metaR r0400
is described by: ECO:0000000
type: Reaction
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
reversible: true
reactant: MODEL1310110026#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.4.4
fast: false
product: MODEL1310110026#
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
modifier: MODEL1310110026#

metaR MI4PP
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110026#
fast: false
modifier: MODEL1310110026#
product: MODEL1310110026#
kinetic law: MODEL1310110026#
name: myo-inositol 4-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.25
is described by: ECO:0000269
type: Reaction
reversible: false

metaR EX 5thf LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (THF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_117ffe86_a6b1_40de_bd1f_4d37651bad41
initial concentration: NaN
boundary condition: true
is encoded by: hsa:H45672
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
name: _H45672_1_m
constant: false

metaR FACOAL203
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase
reactant: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
is: SBO:0000176
modifier: MODEL1310110026#
fast: false
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110026#_3a1f51f4_d081_4176_8358_07fd0c0f3466
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
name: PDE9A
initial concentration: NaN
type: Species
is encoded by: hsa:5152
initial amount: NaN

metaR LNLCCPT2
type: Reaction
reactant: MODEL1310110026#
product: MODEL1310110026#
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110026#
fast: false
name: carnitine transferase
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaM ksi deg8 l
notes: FORMULA: C194H311N13O171S10 CHARGE: -10
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:12936
is: HMDB00143
has only substance units: false
type: Species
name: keratan sulfate I, degradation product 8
is: SBO:0000247

metaM dgdp m
initial concentration: 1.0
name: dGDP(2-)
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
constant: false
is: HMDB00960
is: CHEBI:58595

metaR O2tn
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110026#
product: MODEL1310110026#
fast: false
type: Reaction
name: O2 nuclear transport
reactant: MODEL1310110026#
reversible: true
is: SBO:0000185

metaM c3dc c
notes: FORMULA: C10H16NO6 CHARGE: -1
constant: false
is: HMDB02095
has only substance units: false
initial concentration: 1.0
name: malonyl carnitine
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN

metaM acald c
is: HMDB00990
has only substance units: false
constant: false
is: CHEBI:15343
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
name: acetaldehyde
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247

metaM c226crn m
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/127055
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
initial amount: NaN
name: cervonyl carnitine
is: HMDB06510
constant: false

metaM rbt c
type: Species
initial amount: NaN
name: D-ribitol
is: CHEBI:15963
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB00508
initial concentration: 1.0
constant: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380

metaR EX c51crn
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tiglyl carnitine
type: Reaction

metaM glyb c
has only substance units: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
constant: false
is: SBO:0000247
name: glycine betaine
is: HMDB00043
initial amount: NaN
boundary condition: false
is: CHEBI:17750
initial concentration: 1.0
type: Species

metaR MMEm
fast: false
reactant: MODEL1310110026#
is described by: ECO:0000269
modifier: MODEL1310110026#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/5.1.99.1
notes: GENE_ASSOCIATION: (84693.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.1.99.1 Confidence Level: 4 AUTHORS: PMID:11481338 NOTES:TDV
product: MODEL1310110026#
kinetic law: MODEL1310110026#
name: methylmalonyl-CoA epimerase/racemase
type: Reaction

metaM ahcys m
constant: false
initial concentration: 1.0
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
is: CHEBI:16680
is: C00021
is: HMDB00939
name: S-Adenosyl-L-homocysteine
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species

metaR LNLCCPT1
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
name: carnitine O-palmitoyltransferase
is: SBO:0000176
modifier: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_8bbc2c6f_b215_44b5_9da7_cc3667a98603
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4967
name: OGDH
is: B4E3E9

metaM gluside hs c
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
type: Species
initial concentration: 1.0
is: CHEBI:18368
is: SBO:0000247
constant: false
name: D-glucosyl-N-acylsphingosine

metaR LPCOXp
notes: GENE_ASSOCIATION: (51268.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.3.7 Confidence Level: 4 AUTHORS: PMID:10772957 NOTES:
type: Reaction
reversible: false
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.3.1
name: L-pipecolate oxidase, peroxisomal
is described by: ECO:0000269
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_62a00169_22e4_4818_840b_4f17116e0390
is encoded by: hsa:341947
constant: false
name: COX8C
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
is: Q7Z4L0
initial concentration: NaN

metaR GLRASE
is: SBO:0000176
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 1.1.1.20 Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110026#
reversible: true
kinetic law: MODEL1310110026#
name: glucuronolactone reductase
type: Reaction
reactant: MODEL1310110026#

metaM ile L c
is: CHEBI:17191
name: L-isoleucine
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: HMDB00172
initial amount: NaN

metaR EX xylt LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for xylitol
type: Reaction

metaM ppi c
has only substance units: false
is: CHEBI:0
notes: FORMULA: HO7P2 CHARGE: -3
is: C00013
is: HMDB00250
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
name: Diphosphate
initial concentration: 1.0
constant: false

metaM ddcacoa m
is: C01832
is: SBO:0000247
has only substance units: false
is: HMDB03571
name: Dodecanoyl-CoA (n-C12:0CoA)
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
type: Species
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:57375

metaR EX dhdascb LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dehydroascorbide(1-)
type: Reaction

metaR EX n2m2nmasn LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R exchange
type: Reaction

metaR AG13T18g
product: MODEL1310110026#
fast: false
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110026#_c3f9d0b2_c840_4d3a_b6d7_4d2b026ecea9
initial amount: NaN
initial concentration: NaN
type: Species
name: AK2
is: SBO:0000252
is encoded by: hsa:204
boundary condition: true
constant: false
has only substance units: false

metaR CMPACNAtg
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
product: MODEL1310110026#
name: CMP-Sia Golgi transport via CMP antiport
reversible: true
type: Reaction
fast: false
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD
modifier: MODEL1310110026#

metaM acald e
is: CHEBI:15343
has only substance units: false
initial amount: NaN
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
initial concentration: 1.0
name: acetaldehyde
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB00990
constant: false

metaR FACOAL200
is described by: ECO:0000269
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110026#
reversible: true
modifier: MODEL1310110026#
reactant: MODEL1310110026#
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ

metaM rbt e
name: D-ribitol
is: HMDB00508
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:15963
type: Species
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_aae935bf_7c76_4a39_a7d3_8dd3125626da
is encoded by: hsa:10559
boundary condition: true
is: P78382
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: SLC35A1
type: Species
constant: false

metaM ksii core4 pre3 g
boundary condition: false
constant: false
is: C00130
notes: FORMULA: C55H89N5O38X CHARGE: -1
initial concentration: 1.0
type: Species
name: keratan sulfate II biosynthesis, precursor 3
is: CHEBI:58053
is: SBO:0000247
is: HMDB00175
has only substance units: false
initial amount: NaN

metaR TETPENT6t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110026#
is described by: ECO:0000000
kinetic law: MODEL1310110026#
name: fatty acid transport via diffusion
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110026#
reversible: true

metaR FACOAL206
is described by: ECO:0000269
kinetic law: MODEL1310110026#
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: true
fast: false
modifier: MODEL1310110026#
type: Reaction
reactant: MODEL1310110026#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase

http://identifiers.org/biomodels.db/MODEL1310110026#_b7cfd272_86d7_484c_9d74_ee1375089f79
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

metaR MI34PP
reactant: MODEL1310110026#
fast: false
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.1.3.66
type: Reaction
kinetic law: MODEL1310110026#
reversible: false
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110026#
name: inositol-3,4-bisphosphate 4-phosphatase
notes: GENE_ASSOCIATION: (3631.2) or (3631.1) or (8821.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:7608176,PMID:9295334 NOTES:NCD

metaR EX cholate LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_5f8c589b_9ef0_4ce7_a3de_e160c596f45a
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:57835
initial concentration: NaN
constant: false
name: SLC4A5
initial amount: NaN

metaR EX c8crn
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoyl carnitine
type: Reaction

metaR VLCS2p
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110026#
type: Reaction
product: MODEL1310110026#
reactant: MODEL1310110026#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: PMID:10479480 NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
kinetic law: MODEL1310110026#
reversible: false
name: Very-long-chain-fatty-acid-CoA ligase
is described by: ECO:0000304

metaM ksi pre23 g
type: Species
notes: FORMULA: C185H296N13O153S7X CHARGE: -8
is: CHEBI:28067
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 23
initial amount: NaN
constant: false
boundary condition: false

metaR RE0583C
reactant: MODEL1310110026#
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110026#
type: Reaction
is: SBO:0000176
reversible: true
name: RE0583

metaR LEUKTRE4t
reversible: true
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
fast: false
reactant: MODEL1310110026#
name: leukotriene E4 transport
kinetic law: MODEL1310110026#
type: Reaction
is described by: ECO:0000000

metaR CYSTA
fast: false
reversible: true
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.3 Confidence Level: 2 AUTHORS: PMID:15189131,PMID:7113743 NOTES:MM
name: cysteine transaminase
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.1
modifier: MODEL1310110026#
is described by: ECO:0000304
product: MODEL1310110026#

metaM dodecanac c
constant: false
type: Species
boundary condition: false
initial amount: NaN
is: HMDB00623
name: Dodecanedioic acid
initial concentration: 1.0
notes: FORMULA: C12H20O4 CHARGE: -2
is: SBO:0000247
has only substance units: false

metaR EX his L LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-histidine
type: Reaction

metaM ksi pre1 g
notes: FORMULA: C79H129N5O57X CHARGE: -1
constant: false
initial concentration: 1.0
is: HMDB00175
is: C00130
type: Species
is: SBO:0000247
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 1
boundary condition: false
is: CHEBI:58053
initial amount: NaN

metaM HC02207 e
is: SBO:0000247
initial amount: NaN
name: prostaglandin-c2
type: Species
boundary condition: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:27555

http://identifiers.org/biomodels.db/MODEL1310110026#_372425fd_9693_4298_aa62_bca99b2070f0
is encoded by: hsa:10201
is: O75414
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
name: NME6
type: Species
initial amount: NaN

metaM m6masnB2 g
boundary condition: false
has only substance units: false
is: HMDB00573
type: Species
is: SBO:0000247
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: CHEBI:30825
initial concentration: 1.0
notes: FORMULA: C58H97N2O45X CHARGE: 0
initial amount: NaN
constant: false

metaR GALASE6ly
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
is: SBO:0000176
product: MODEL1310110026#
reactant: MODEL1310110026#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: beta-galactosidase, lysosomal

metaR FACOAL204
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269
fast: false
reactant: MODEL1310110026#
name: fatty-acid--CoA ligase
product: MODEL1310110026#
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT
kinetic law: MODEL1310110026#
type: Reaction
is: SBO:0000176
reversible: true

metaM L2aadp6sa c
initial amount: NaN
is: CHEBI:17917
type: Species
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
constant: false
has only substance units: false
is: HMDB01263
name: L-allysine
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR r1088
product: MODEL1310110026#
name: Active transport
is: SBO:0000185
fast: false
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_57e3769b_3be2_40d1_a8cb_de40f29e41f1
is: Q14916
name: SLC17A1
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:6568
has only substance units: false
constant: false

metaR r0409
notes: GENE_ASSOCIATION: (6476.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275 NOTES:
is described by: ECO:0000000
name: UTP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
fast: false
product: MODEL1310110026#
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
reactant: MODEL1310110026#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.10
reversible: true
type: Reaction

metaR AIRCr
name: phosphoribosylaminoimidazole carboxylase
is described by: ECO:0000269
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.2.6
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: true
type: Reaction
product: MODEL1310110026#

metaR RE1525M
is version of: http://identifiers.org/ec-code/4.2.1.107
name: RE1525
is: SBO:0000176
product: MODEL1310110026#
reactant: MODEL1310110026#
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: true

metaR SIAT4Bg
is: SBO:0000176
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
reversible: false
type: Reaction
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.4.99.4
reactant: MODEL1310110026#
is described by: ECO:0000269
name: Beta-galactoside alpha-2,3-sialyltransferase, Golgi apparatus
fast: false

metaR O2tp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
name: O2 transport, peroxisomal
is: SBO:0000185
reactant: MODEL1310110026#
fast: false
product: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
reversible: true

metaR ELAIDt
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
kinetic law: MODEL1310110026#
is: SBO:0000185
type: Reaction
product: MODEL1310110026#
is described by: ECO:0000000
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110026#_daa51d78_ab3b_416a_a29e_d732e2e49038
has only substance units: false
is: O43924
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
name: PDE6D
boundary condition: true
is encoded by: hsa:5147
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110026#_59b1dd16_1d70_4438_abc2_67f4e2138bb1
is encoded by: hsa:BE966236
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252
name: _BE966236_1_c

http://identifiers.org/biomodels.db/MODEL1310110026#_a860246b_ba7c_431e_95b3_807d892b90c1
is: Q9HBH5
name: RDH14
type: Species
constant: false
is encoded by: hsa:57665
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false

metaM tcynt c
type: Species
is: CHEBI:18022
is: HMDB01453
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
name: thiocyanate
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_dcea8caa_f2c6_42b1_b09b_34fb00648517
type: Species
name: COX3
boundary condition: true
has only substance units: false
initial concentration: NaN
is: P00414
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:4514

metaM 4hglusa m
is: HMDB06556
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938
initial amount: NaN
is: CHEBI:27809
boundary condition: false
constant: false
name: L-4-hydroxyglutamic semialdehyde
initial concentration: 1.0

metaR VLCS2r
fast: false
name: Very-long-chain-fatty-acid-CoA ligase
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
is described by: ECO:0000304
product: MODEL1310110026#
modifier: MODEL1310110026#
reactant: MODEL1310110026#
is: SBO:0000176
kinetic law: MODEL1310110026#
reversible: false
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_dbb911c8_df0c_4086_880d_e1c519ff5eac
initial concentration: NaN
is: Q9UBF8
is: SBO:0000252
has only substance units: false
name: PI4KB
constant: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:5298

metaR FACOAL205
kinetic law: MODEL1310110026#
is described by: ECO:0000000
fast: false
product: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
modifier: MODEL1310110026#
reversible: true
name: fatty-acid--CoA ligase
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110026#_6a10c2ed_336d_4496_9f32_aa1eaf623195
type: Species
is encoded by: hsa:60481
has only substance units: false
initial concentration: NaN
is: F6SH78
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: ELOVL5
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_b4ae8014_8283_4ffe_9a80_5674f2d931a7
is: B1AM93
initial concentration: NaN
is encoded by: hsa:4702
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
name: NDUFA8

metaR EX ha LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan exchange
type: Reaction

metaM uppg3 c
is: HMDB01086
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C40H36N4O16 CHARGE: -8 HEPATONET_1.0_ABBREVIATION: HC00643 EHMN_ABBREVIATION: C01051
is: C01051
type: Species
is: CHEBI:57308
constant: false
name: Uroporphyrinogen III
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110026#_5d2ccf58_f5f1_444f_8977_49eeee9bb509
initial concentration: NaN
type: Species
is encoded by: hsa:6560
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
is: F5H066
name: SLC12A4
constant: false

metaM galgbside hs g
constant: false
name: galactosylgloboside
notes: FORMULA: C50H89N2O27FULLRCO CHARGE: 0
is: CHEBI:18259
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaM gluside hs g
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: D-glucosyl-N-acylsphingosine
constant: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
boundary condition: false
initial concentration: 1.0
is: CHEBI:18368
type: Species

metaM 3mb2coa m
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069
initial amount: NaN
name: 3-methylbut-2-enoyl-CoA(4-)
constant: false
is: HMDB01493
is: CHEBI:57344

metaR RE3006M
name: RE3006
type: Reaction
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: true
reactant: MODEL1310110026#
product: MODEL1310110026#
is described by: ECO:0000000
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17

metaM HC02207 c
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
name: prostaglandin-c2
is: CHEBI:27555
boundary condition: false

metaR r0407
is version of: http://identifiers.org/ec-code/1.4.3.5
is described by: ECO:0000000
product: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is: SBO:0000176
modifier: MODEL1310110026#
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_a3a717ed_96e5_4d4e_929b_226efec80e34
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:5152
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
name: PDE9A

http://identifiers.org/biomodels.db/MODEL1310110026#_3428e990_0288_4e60_9dd9_e617227bd44b
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:205
name: AK4

metaR r0732
reversible: false
reactant: MODEL1310110026#
is: SBO:0000176
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
fast: false
is described by: ECO:0000000
product: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110026#_ce6d0eff_dcea_4e99_a4e1_a3df40427b8f
name: ACO2
has only substance units: false
is encoded by: hsa:50
is: SBO:0000252
initial amount: NaN
type: Species
is: Q99798
constant: false
boundary condition: true
initial concentration: NaN

metaM dolglcp U r
initial concentration: 1.0
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
is: CHEBI:15812
is: SBO:0000247
has only substance units: false
type: Species

metaR ARACHDtr
is: SBO:0000185
name: intracellular transport
kinetic law: MODEL1310110026#
type: Reaction
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ

metaR r0408
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
is: SBO:0000176
modifier: MODEL1310110026#
reversible: true
product: MODEL1310110026#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.5
kinetic law: MODEL1310110026#
is described by: ECO:0000000
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:

metaR r0733
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/1.5.1.12
is: SBO:0000176
product: MODEL1310110026#
type: Reaction
reactant: MODEL1310110026#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110026#
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35

metaM ahcys c
initial amount: NaN
initial concentration: 1.0
name: S-Adenosyl-L-homocysteine
type: Species
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
is: C00021
is: CHEBI:16680
boundary condition: false
constant: false
is: HMDB00939
is: SBO:0000247
has only substance units: false

metaM retfa c
type: Species
constant: false
boundary condition: false
name: fatty acid retinol
is: HMDB00305
is: SBO:0000247
is: CHEBI:50211
initial concentration: 1.0
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_f453940d_5332_477e_b6ff_2ef656e07714
has only substance units: false
is encoded by: hsa:490
is: P20020
constant: false
is: SBO:0000252
name: ATP2B1
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110026#_3f4ea452_3768_4dd2_87d8_b74748d6be9c
name: PDE9A
initial amount: NaN
type: Species
has only substance units: false
constant: false
is encoded by: hsa:5152
is: SBO:0000252
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_591a2f2b_031c_4a6c_a9a6_ad3804a2c966
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:T83654
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
name: _T83654_1_m

metaM ksi deg21 l
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:12936
constant: false
name: keratan sulfate I, degradation product 21
notes: FORMULA: C132H213N9O114S6 CHARGE: -6
has only substance units: false
is: HMDB00143
type: Species
boundary condition: false

metaR 3MOBte
product: MODEL1310110026#
reactant: MODEL1310110026#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
name: Transport of 3-methyl-2-oxobutanoate
fast: false
kinetic law: MODEL1310110026#
is: SBO:0000185
is described by: ECO:0000134

metaR r0734
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is: SBO:0000176
kinetic law: MODEL1310110026#
type: Reaction
is described by: ECO:0000000
reversible: false
product: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
fast: false

metaR RE3244R
product: MODEL1310110026#
is: SBO:0000176
modifier: MODEL1310110026#
reversible: true
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
reactant: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
fast: false
is described by: ECO:0000000
name: RE3244

metaM c226crn c
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
boundary condition: false
is: HMDB06510
initial concentration: 1.0
name: cervonyl carnitine
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/127055
constant: false
type: Species
initial amount: NaN

metaM m1mpdol U c
initial concentration: 1.0
has only substance units: false
is: CHEBI:28067
notes: FORMULA: C1305H2140N20O270P20 CHARGE: -20 INCHI: InChI=1S/C53H92N2O27P2/c1-27(2)13-9-14-28(3)15-10-16-29(4)17-11-18-30(5)19-12-20-31(6)21-22-73-83(69,70)82-84(71,72)81-51-39(55-33(8)61)43(65)47(37(26-59)77-51)78-50-38(54-32(7)60)42(64)48(36(25-58)76-50)79-53-46(68)49(41(63)35(24-57)75-53)80-52-45(67)44(66)40(62)34(23-56)74-52/h13,15,17,19,31,34-53,56-59,62-68H,9-12,14,16,18,20-26H2,1-8H3,(H,54,60)(H,55,61)(H,69,70)(H,71,72)/b28-15+,29-17+,30-19+/t31?,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47-,48-,49+,50+,51-,52-,53+/m1/s1
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human uterine homolog

metaR DPHMBDCm
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11051212,PMID:7380842 NOTES:enzyme has not been identified yet IT
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
reversible: false
is described by: ECO:0000000
fast: false
product: MODEL1310110026#
is: SBO:0000176
name: 3-Decaprenyl-4-hydroxy-5-methoxybenzoate decarboxylation

http://identifiers.org/biomodels.db/MODEL1310110026#_77cadd7e_b2c5_4b8a_a89e_04b7fc1b9a5b
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:160851
name: DGKH
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: A8K0I1
type: Species

metaR r0735
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
type: Reaction
reactant: MODEL1310110026#
is described by: ECO:0000000
product: MODEL1310110026#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: true

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

metaM retfa e
name: fatty acid retinol
is: HMDB00508
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
is: CHEBI:15963
boundary condition: false

metaM tetpent3coa c
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4,7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-/t34-,38-,39-,40?,44-/m1/s1
is: SBO:0000247
name: tetracosapentaenoyl coenzyme A, n-3
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
is: C16167
initial concentration: 1.0
type: Species

metaR ACCOAgt
kinetic law: MODEL1310110026#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12739170 NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ
modifier: MODEL1310110026#
type: Reaction
reactant: MODEL1310110026#
product: MODEL1310110026#
fast: false
reversible: true
is described by: ECO:0000269
name: acetyl-coa transport

http://identifiers.org/biomodels.db/MODEL1310110026#_f16d1f15_d37f_4fd9_a65d_e3c2e747eeaf
is encoded by: hsa:36
boundary condition: true
name: ACADSB
has only substance units: false
is: SBO:0000252
is: P45954
type: Species
initial amount: NaN
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_8612341d_21a3_49ec_bdaf_752c883598d6
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:1718
initial amount: NaN
type: Species
name: DHCR24
boundary condition: true
is: Q15392
has only substance units: false

metaR ADPACDAc
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of adipic acid for formation of adipoyl carnitine
type: Reaction

metaR UMPK2n
type: Reaction
reactant: MODEL1310110026#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
modifier: MODEL1310110026#
name: UMP kinase (CTP),nuclear
is: SBO:0000176
reversible: true
product: MODEL1310110026#
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110026#_9d1a57d6_ec38_4484_94ae_9e20f7fc4107
name: ACP5
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:54
type: Species
constant: false
is: P13686
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_b4c9eeac_300a_4d41_bbc4_011cf55cc210
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
name: SLC25A13
has only substance units: false
initial concentration: NaN
is: Q9UJS0
boundary condition: true
is encoded by: hsa:10165

metaR r1147
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110026#
product: MODEL1310110026#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
fast: false

metaR DURIt
name: deoxyuridine transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110026#
type: Reaction
reversible: true
reactant: MODEL1310110026#
fast: false
product: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_47ac55b5_0974_4b83_b8db_b0bb4b55ade7
constant: false
is: P47895
initial concentration: NaN
is encoded by: hsa:220
type: Species
is: SBO:0000252
has only substance units: false
name: ALDH1A3
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110026#_195a91e4_902a_4ea7_ab4c_d12407f8b50d
is: SBO:0000252
is encoded by: hsa:1337
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is: P12074
type: Species
name: COX6A1
initial concentration: NaN

metaM 5dhf l
boundary condition: false
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
name: pentaglutamyl folate (DHF)
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
is: HMDB06487
is: SBO:0000247
initial amount: NaN

metaM mlthf m
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:15636
boundary condition: false
name: 5,10-Methylenetetrahydrofolate
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB01533
is: C00143

metaR r1292
fast: false
name: Postulated transport reaction
type: Reaction
kinetic law: MODEL1310110026#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reactant: MODEL1310110026#
product: MODEL1310110026#

metaR EX tmndnc LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: timnodonic acid exchange
type: Reaction

metaR HEX10
is version of: http://identifiers.org/ec-code/2.7.1.1
notes: GENE_ASSOCIATION: (2645.1) or (3099.1) or (3098.3) or (2645.2) or (80201.1) or (3098.2) or (2645.3) or (3098.1) or (3098.4) or (3101.1) or (3098.5) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.1 Confidence Level: 1 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase.
fast: false
kinetic law: MODEL1310110026#
type: Reaction
reversible: false
modifier: MODEL1310110026#
is: SBO:0000176
is described by: ECO:0000212
name: hexokinase (D-glucosamine:ATP)
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.7.1.2
reactant: MODEL1310110026#

metaR NACHEXA17ly
kinetic law: MODEL1310110026#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
type: Reaction
product: MODEL1310110026#
modifier: MODEL1310110026#
name: beta-N-acetylhexosaminidase A, lysosomal
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_2e253b14_f9da_4c46_9e49_7505820417e5
constant: false
has only substance units: false
initial amount: NaN
has part: Q8IV97
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:8140
is: SBO:0000297
name: SLC3A2:SLC7A5

metaM gluside hs r
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:18368
type: Species
name: D-glucosyl-N-acylsphingosine
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110026#_25d2085d_146e_4c2f_bb95_0d96b39300a4
is: SBO:0000252
is encoded by: hsa:3098
constant: false
initial amount: NaN
has only substance units: false
name: HK1
initial concentration: NaN
is: P19367
type: Species
boundary condition: true

metaR r1908
is described by: ECO:0000000
modifier: MODEL1310110026#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110026#
product: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
name: Y+LAT2 Utilized transport
is: SBO:0000185

metaR r0517
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
fast: false
is: SBO:0000176
product: MODEL1310110026#
type: Reaction
modifier: MODEL1310110026#
reversible: true
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.17.4.1
reactant: MODEL1310110026#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:

metaM 5dhf m
name: pentaglutamyl folate (DHF)
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
is: HMDB06487
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
constant: false

metaM ile L m
name: L-isoleucine
has only substance units: false
initial concentration: 1.0
is: HMDB00172
type: Species
boundary condition: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: CHEBI:17191
constant: false
initial amount: NaN
is: SBO:0000247

metaR r1291
kinetic law: MODEL1310110026#
is: SBO:0000185
reactant: MODEL1310110026#
product: MODEL1310110026#
name: Postulated transport reaction
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is described by: ECO:0000000
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110026#_9ce8dedf_7da3_4b44_ab1c_f11c95407fa3
initial amount: NaN
is encoded by: hsa:230
boundary condition: true
has only substance units: false
is: P09972
initial concentration: NaN
type: Species
constant: false
name: ALDOC
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110026#_f1afee50_8939_4e22_bfc7_94b24c7d6d1f
initial concentration: NaN
boundary condition: true
is: P30613
type: Species
name: PKLR
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:5313

metaR ECOAH9m
fast: false
reversible: true
reactant: MODEL1310110026#
product: MODEL1310110026#
is described by: ECO:0000304
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
kinetic law: MODEL1310110026#
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
is: SBO:0000176
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

metaR PROSTGF2t
is described by: ECO:0000269
is: SBO:0000185
fast: false
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
product: MODEL1310110026#
name: prostaglandin uniport
reactant: MODEL1310110026#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_840a6f95_fb13_4b14_b992_61dc06cca568
type: Species
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:2686
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: GGT7
is: A0PJJ9

http://identifiers.org/biomodels.db/MODEL1310110026#_0fe407eb_b5cf_4896_afbb_120be1980a9a
is encoded by: hsa:5091
name: PC
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
is: P11498
initial amount: NaN

metaR FAOXC200180m
fast: false
reactant: MODEL1310110026#
is: SBO:0000176
product: MODEL1310110026#
reversible: false
name: Beta oxidation of long chain fatty acid
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
kinetic law: MODEL1310110026#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000000

metaR r0514
kinetic law: MODEL1310110026#
fast: false
modifier: MODEL1310110026#
is: SBO:0000176
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:4396284,PMID:6882460,PMID:962851 NOTES:
type: Reaction
reversible: false
name: Dihydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
reactant: MODEL1310110026#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110026#_3708b96d_a02c_40ef_b6c0_79f8586f66e6
name: SDHB
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:6390
has only substance units: false
is: P21912
boundary condition: true
initial amount: NaN

metaR IDOURtly
is: SBO:0000185
type: Reaction
reversible: true
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000269
fast: false
product: MODEL1310110026#
modifier: MODEL1310110026#
name: iduronate transport into lysososme
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261,PMID:9852127 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 (for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD added IdoA reaction - NCD

metaR Asn X Ser Thrtr
is: SBO:0000185
name: Asn-X-Ser/Thr transport (from ER to lysosome)
reversible: true
reactant: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:10823827,PMID:12845534 NOTES:
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110026#
product: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_2302ff14_a80b_4cdc_ae54_c68aa0499577
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000297
has part: Q8WYR1
type: Species
name: PIK3R5:PIK3CG
is encoded by: hsa:23533

http://identifiers.org/biomodels.db/MODEL1310110026#_97f8cfd1_6df2_47c7_b49d_c7040af39391
boundary condition: true
name: AK2
is: SBO:0000252
constant: false
is encoded by: hsa:204
is: P54819
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_7b3ac2d4_0930_4108_af47_b7238ca16116
is: SBO:0000252
name: TM7SF2
is encoded by: hsa:7108
constant: false
has only substance units: false
is: O76062
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN

metaR r1148
product: MODEL1310110026#
is: SBO:0000185
name: Active transport
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110026#
reversible: true
kinetic law: MODEL1310110026#
is described by: ECO:0000000

metaR TYRt
is described by: ECO:0000269
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
reversible: true
kinetic law: MODEL1310110026#
name: L-tyrosine transport
modifier: MODEL1310110026#
type: Reaction
reactant: MODEL1310110026#
product: MODEL1310110026#

metaR r1906
modifier: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110026#
is described by: ECO:0000000
is: SBO:0000185
name: Y+LAT2 Utilized transport
product: MODEL1310110026#
reversible: false
type: Reaction
fast: false

metaM nicrnt c
constant: false
is: SBO:0000247
has only substance units: false
name: Nicotinate D-ribonucleotide
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
is: C01185
boundary condition: false
is: HMDB01132
is: CHEBI:57502
type: Species
initial amount: NaN
initial concentration: 1.0

metaR PNTOte
reversible: true
kinetic law: MODEL1310110026#
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of (R)-Pantothenate
is: SBO:0000185
reactant: MODEL1310110026#
type: Reaction
is described by: ECO:0000134
fast: false

metaM tcynt e
is: CHEBI:18022
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
is: HMDB01453
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: thiocyanate
type: Species
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_fd74b33b_bcf6_4728_8e0f_c0177babe25e
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000297
has only substance units: false
constant: false
name: SUCLG1:SUCLA2
is encoded by: hsa:8803
has part: E5KS60
initial concentration: NaN

metaM clpn hs c
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB02704
is: CHEBI:21338
notes: FORMULA: CHARGE: 0
has only substance units: false
name: clpn_hs[c]

metaR r0627
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
fast: false
kinetic law: MODEL1310110026#
reversible: true
is: SBO:0000176
product: MODEL1310110026#
reactant: MODEL1310110026#
type: Reaction
is described by: ECO:0000000

metaR RE3269C
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (8897.1) or (8897.3) or (8897.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:Recin 1 had irreversible version - PI35P3P - GPR from PI35P3P was added - May 2011 IT
kinetic law: MODEL1310110026#
fast: false
reversible: true
modifier: MODEL1310110026#
name: RE3269
is version of: http://identifiers.org/ec-code/3.1.3.48
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000000

metaM ksi deg39 l
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
is: HMDB00143
has only substance units: false
is: CHEBI:12936
notes: FORMULA: C48H81N3O36 CHARGE: 0
initial amount: NaN
name: keratan sulfate I, degradation product 39
is: SBO:0000247

metaM 3snpyr m
is: HMDB02332
name: 3-Sulfinopyruvate
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C3H2O5S CHARGE: -2 INCHI: InChI=1S/C3H4O5S/c4-2(3(5)6)1-9(7)8/h1H2,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C05527
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:1665

metaR OIVD3m
kinetic law: MODEL1310110026#
is described by: ECO:0000269
name: 2-oxoisovalerate dehydrogenase (acylating; 3-methyl-2-oxopentanoate), mitochondrial
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.168
is version of: http://identifiers.org/ec-code/1.2.4.4
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.4
reversible: false
notes: GENE_ASSOCIATION: (1629.1) and (594.1 and 593.1) and (1738.1) or (1629.1) and (1738.1) and (594.2 and 593.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:1429740,PMID:2914958 NOTES:
product: MODEL1310110026#
modifier: MODEL1310110026#
is: SBO:0000176
reactant: MODEL1310110026#

metaM icit m
is: CHEBI:16087
is: SBO:0000247
is: HMDB00193
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
boundary condition: false
name: Isocitrate
constant: false
is: C00311
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_75572a2c_573a_4193_bc94_99a6ec2a94a3
is: O75874
name: IDH1
type: Species
constant: false
has only substance units: false
is encoded by: hsa:3417
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaR RE1810M
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:
fast: false
reactant: MODEL1310110026#
product: MODEL1310110026#
name: RE1810
is: SBO:0000176
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110026#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_fcff30b6_6b48_4cd3_8339_bdfd7e1459ce
constant: false
type: Species
name: IDUA
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:3425
is: P35475
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_0a0a1db6_4b87_456f_8c4d_218dc0ba574a
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
name: NDUFB7
is: SBO:0000252
is encoded by: hsa:4713
is: P17568

metaR r2308
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110026#
product: MODEL1310110026#
fast: false
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:

metaM maltttr e
boundary condition: false
is: C02052
is: SBO:0000247
is: HMDB01296
name: Maltotetraose
constant: false
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5141
type: Species

metaM adpac c
initial concentration: 1.0
name: adipic acid
constant: false
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H8O4 CHARGE: -2
is: SBO:0000247
has only substance units: false
is: HMDB00448

metaR SEBCOACROT
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_e845886a_6fbd_4ed9_9371_69653144d1e4
has only substance units: false
name: MAN1A2
is: O60476
type: Species
is encoded by: hsa:10905
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_8001797e_f604_4656_b167_9f6ca66393bd
type: Species
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: ACO1
is: P21399
initial amount: NaN
boundary condition: true
is encoded by: hsa:48

metaR r0629
fast: false
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.1.4.1
is: SBO:0000176
kinetic law: MODEL1310110026#
reversible: true
reactant: MODEL1310110026#
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
is version of: http://identifiers.org/ec-code/3.6.1.22
type: Reaction
product: MODEL1310110026#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110026#_64287041_5402_48e0_87af_6474be3b9bb0
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:54539
name: NDUFB11
is: Q9NX14
type: Species
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_238d88ed_8182_4857_a0ac_b3fdfa26ef1b
type: Species
is encoded by: hsa:230
initial amount: NaN
boundary condition: true
name: ALDOC
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: P09972

http://identifiers.org/biomodels.db/MODEL1310110026#_7bfd0adb_29b5_4253_ba72_8b7edb2c7495
boundary condition: true
is: Q9P0Z9
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
name: PIPOX
is encoded by: hsa:51268

http://identifiers.org/biomodels.db/MODEL1310110026#_4099e5fb_315f_4389_a0bc_be78fbc0ea0d
boundary condition: true
is encoded by: hsa:80308
type: Species
is: SBO:0000252
has only substance units: false
name: FLAD1
constant: false
initial concentration: NaN
initial amount: NaN

metaM guln r
initial amount: NaN
type: Species
name: L-gulonate
has only substance units: false
is: CHEBI:13115
boundary condition: false
is: HMDB03290
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800

metaM ksii core4 deg3 l
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
name: keratan sulfate II (core 4-linked), degradation product 3
notes: FORMULA: C66H107N6O51S2X CHARGE: -2
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:12936
is: HMDB00143

metaM cytd c
is: HMDB00089
is: CHEBI:17562
boundary condition: false
is: C00475
name: Cytidine
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
constant: false

metaR r1378
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
kinetic law: MODEL1310110026#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110026#
fast: false
reversible: true
reactant: MODEL1310110026#

metaR r0630
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.2
type: Reaction
kinetic law: MODEL1310110026#
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.1.3.1
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
reversible: true
fast: false
reactant: MODEL1310110026#
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
is: SBO:0000176
modifier: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_aaa8b442_6d50_4ef4_914b_2c82de62083e
type: Species
name: TUSC3
has only substance units: false
is: Q13454
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:7991
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_7442c37c_9e3b_4745_8542_4f2e2febc2f6
has part: Q8TEQ8
has part: Q07326
boundary condition: true
is: SBO:0000297
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5281
is encoded by: hsa:84720
constant: false
has only substance units: false
name: PIGF:PIGO

http://identifiers.org/biomodels.db/MODEL1310110026#_baa9fd08_9ac7_4f18_b026_43579582f834
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:84701
boundary condition: true
constant: false
is: Q96KJ9
name: COX4I2
has only substance units: false
initial concentration: NaN

metaM core2 g
constant: false
initial concentration: 1.0
is: CHEBI:15876
initial amount: NaN
name: Core 2
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C22H37N2O15X CHARGE: 0

metaR TSULt4 3
name: thiosulfate transport via sodium symport
is: SBO:0000185
reactant: MODEL1310110026#
fast: false
is described by: ECO:0000269
product: MODEL1310110026#
reversible: true
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
type: Reaction
notes: GENE_ASSOCIATION: (6561.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10811962,PMID:11161786 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110026#_a8bc964a_91f7_41ad_9281_02f638ddcc73
constant: false
type: Species
has only substance units: false
name: _642502_1_c
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:642502

metaM CE5854 e
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
constant: false
boundary condition: false
is: CHEBI:27485
name: gama-CEHC-glucuronide
has only substance units: false
initial concentration: 1.0
is: HMDB02710

metaM sbt D c
name: D-glucitol
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
is: CHEBI:17924
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB00247

http://identifiers.org/biomodels.db/MODEL1310110026#_3b3d0f8a_541d_419d_b78f_4ce87469aca8
type: Species
initial amount: NaN
name: SLCO2A1
initial concentration: NaN
is: SBO:0000252
is: Q92959
is encoded by: hsa:6578
constant: false
boundary condition: true
has only substance units: false

metaM 34dhoxmand m
constant: false
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
is: HMDB01866
boundary condition: false
name: 3,4-Dihydroxymandelate
has only substance units: false
is: CHEBI:27637
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN

metaM ksi pre34 g
boundary condition: false
is: HMDB00175
is: CHEBI:58053
is: C00130
type: Species
notes: FORMULA: C241H385N17O202S10X CHARGE: -11
initial amount: NaN
constant: false
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 34
has only substance units: false
initial concentration: 1.0

metaR PI3P3Pn
name: phosphatidylinositol-3-phosphate 3-phosphatase, nuclear
is described by: ECO:0000000
product: MODEL1310110026#
fast: false
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12728269 NOTES:EC 3.1.3.- NCD
type: Reaction

metaM dhbpt c
is: CHEBI:20680
type: Species
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: 6,7-dihydrobiopterin
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
is: HMDB00038

metaM malcoa c
is: HMDB01175
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:57384
initial amount: NaN
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
is: C00083
boundary condition: false
type: Species
has only substance units: false
name: Malonyl-CoA

metaR XOLDIOLONEt
fast: false
reversible: true
type: Reaction
name: lipid, flip-flop intracellular transport
is described by: ECO:0000000
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
product: MODEL1310110026#
reactant: MODEL1310110026#
is: SBO:0000185

metaM ksii core2 e
boundary condition: false
is: SBO:0000247
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
name: keratan sulfate II (core 2-linked)
initial amount: NaN
is: CHEBI:17268
is: HMDB00211
initial concentration: 1.0
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_6727c7eb_d684_4b36_b7ef_96db310fed33
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5625
is: SBO:0000252
boundary condition: true
constant: false
type: Species
name: PRODH
is: O43272
initial amount: NaN

metaM c8crn c
has only substance units: false
is: HMDB00791
initial concentration: 1.0
is: C02838
is: SBO:0000247
type: Species
notes: FORMULA: C15H29NO4 CHARGE: 0
boundary condition: false
constant: false
initial amount: NaN
name: octanoyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110026#_dc7cdb42_31b4_4aab_bb78_2333ac4e4e41
is: SBO:0000252
name: ACP6
initial concentration: NaN
has only substance units: false
boundary condition: true
is: Q9NPH0
is encoded by: hsa:51205
initial amount: NaN
type: Species
constant: false

metaM chtn e
is: CHEBI:17029
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
is: SBO:0000247
has only substance units: false
name: chitin
notes: FORMULA: C24H41N3O16 CHARGE: 0 INCHI: InChI=1S/C24H41N3O16/c1-7(31)25-13-18(36)20(11(5-29)39-22(13)38)42-24-15(27-9(3)33)19(37)21(12(6-30)41-24)43-23-14(26-8(2)32)17(35)16(34)10(4-28)40-23/h10-24,28-30,34-38H,4-6H2,1-3H3,(H,25,31)(H,26,32)(H,27,33)/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+,24+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02118
is: HMDB03362

metaR r1377
reversible: true
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110026#_01f97ed8_895f_4d09_9eed_2fa61cdbc6d4
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:23236
name: PLCB1
constant: false

metaM dolmanp U c
has only substance units: false
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
type: Species
constant: false
is: CHEBI:15809
is: SBO:0000247
name: Dolichyl phosphate D-mannose, human uterine homolog
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaR r0853
type: Reaction
kinetic law: MODEL1310110026#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8132483 NOTES:
product: MODEL1310110026#
reactant: MODEL1310110026#
fast: false
is: SBO:0000185
name: Facilitated diffusion
reversible: false

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_0d0c8595_c0af_456c_b371_6776589b467e
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
name: PIGO
is: Q8TEQ8
type: Species
is encoded by: hsa:84720
boundary condition: true

metaM ipdp c
type: Species
constant: false
boundary condition: false
is: C00129
has only substance units: false
name: Isopentenyl diphosphate
is: CHEBI:128769
initial concentration: 1.0
notes: FORMULA: C5H9O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
is: SBO:0000247
is: HMDB01347
initial amount: NaN

metaR IVCOAACBP
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Isovaleryl-CoA from mitochondria into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_b3131a37_e984_4d59_9e8f_55e834e8cdb7
is encoded by: hsa:23600
initial concentration: NaN
is: Q3KT79
constant: false
name: AMACR
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110026#_29deec6e_8a0b_41e5_93a8_f416e4423421
name: ATP5A1
initial concentration: NaN
is: SBO:0000252
is: A8K092
initial amount: NaN
type: Species
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:498

http://identifiers.org/biomodels.db/MODEL1310110026#_628cc598_6a65_4468_83b2_8cec963c11e8
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5152
constant: false
boundary condition: true
type: Species
name: PDE9A
initial concentration: NaN
has only substance units: false

metaM oagd3 hs g
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
initial concentration: 1.0
has only substance units: false
is: HMDB01514
is: SBO:0000247
type: Species
is: CHEBI:17315
constant: false
is: C00329
name: 9-O-Acetylated GD3
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_3d8f435e_789e_4de1_b24e_036f9eccfec1
is encoded by: hsa:34
constant: false
name: ACADM
boundary condition: true
is: P11310
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR r1374
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:17267599 NOTES:
product: MODEL1310110026#
name: EC:3.2.1.14
fast: false
reactant: MODEL1310110026#
is described by: ECO:0000000
kinetic law: MODEL1310110026#
reversible: false
type: Reaction

metaM trp L e
initial amount: NaN
has only substance units: false
is: HMDB00929
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
type: Species
constant: false
is: CHEBI:16828
boundary condition: false
initial concentration: 1.0
name: L-tryptophan
is: SBO:0000247

metaR r0634
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
modifier: MODEL1310110026#
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
fast: false
reactant: MODEL1310110026#
product: MODEL1310110026#
is: SBO:0000176
kinetic law: MODEL1310110026#
type: Reaction
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/3.1.4.1

metaR 4HGLSDm
is: SBO:0000176
kinetic law: MODEL1310110026#
is described by: ECO:0000212
name: L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial
reversible: true
fast: false
modifier: MODEL1310110026#
type: Reaction
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.5.1.12
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD

metaM nadh x
is: SBO:0000247
initial concentration: 1.0
is: HMDB01487
constant: false
name: Nicotinamide adenine dinucleotide - reduced
is: CHEBI:57945
boundary condition: false
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/3306
is: C00004
initial amount: NaN

metaR EX lnlncg LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gamma-linolenic acid exchange
type: Reaction

metaR r0523
is described by: ECO:0000000
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.17.4.1
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
reactant: MODEL1310110026#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110026#
product: MODEL1310110026#

metaR RE3245C
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000000
name: RE3245
type: Reaction
fast: false
is: SBO:0000176
reversible: true

metaR RE3050R
name: RE3050
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215 NOTES:
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110026#
product: MODEL1310110026#
kinetic law: MODEL1310110026#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110026#_ecc39cce_381a_4fac_8e9b_c3e9559bc5dd
is: Q9UPR5
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:6543
constant: false
initial concentration: NaN
is: SBO:0000252
name: SLC8A2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_73e76bab_aa40_493e_b905_213e79316f86
constant: false
is: SBO:0000252
boundary condition: true
name: PPCDC
has only substance units: false
is encoded by: hsa:60490
initial concentration: NaN
type: Species
is: Q96CD2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_4decd510_ee9f_46c3_9dbc_e60f89556e05
boundary condition: true
is encoded by: hsa:8503
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: Q92569
name: PIK3R3
type: Species
is: SBO:0000252

metaR r1375
name: Transport reaction
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:17267599 NOTES:
product: MODEL1310110026#
is: SBO:0000185
fast: false
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: false

metaM c8crn e
is: HMDB00791
has only substance units: false
is: C02838
constant: false
is: SBO:0000247
notes: FORMULA: C15H29NO4 CHARGE: 0
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: octanoyl carnitine
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_77d7a07e_c941_4df1_948c_8df9bbf6da64
is encoded by: hsa:522
has only substance units: false
boundary condition: true
initial concentration: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
has part: Q6NZ59
is: SBO:0000297
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_1e3db827_61ae_4b08_9493_7b1c2b49ee75
name: ACO2
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:50
is: SBO:0000252
is: Q99798
initial amount: NaN
boundary condition: true

metaM HC02202 c
type: Species
is: SBO:0000247
initial amount: NaN
name: prostaglandin A1(1-)
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
has only substance units: false
is: CHEBI:57398
initial concentration: 1.0
boundary condition: false
constant: false

metaR r0522
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
reactant: MODEL1310110026#
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110026#
type: Reaction
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
kinetic law: MODEL1310110026#
product: MODEL1310110026#
is: SBO:0000176
fast: false

metaR CYSTALArBATtc
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Cystine into the cell in exchange for L-Alanine by b0,+AT transporter at the apical surfaces of the membranes of small intestine and renal cells.
type: Reaction

metaR r0633
reactant: MODEL1310110026#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.3
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
reversible: true
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_f7a12193_4825_4945_9232_3b081bc5ee34
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:AA278423
name: _AA278423_1_m
is: SBO:0000252
initial amount: NaN

metaM oagd3 hs e
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
is: CHEBI:18421
initial concentration: 1.0
initial amount: NaN
is: HMDB02168
type: Species
is: SBO:0000247
constant: false
name: 9-O-Acetylated GD3
boundary condition: false
has only substance units: false

metaR EX cyan LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen cyanide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_77b839c6_a71c_43c1_ae82_0b0860249dc3
is: P51687
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:6821
boundary condition: true
name: SUOX
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_dbc2069c_1937_425e_b7ce_45e93a44cb1d
initial amount: NaN
is: Q9Y2C3
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:10317
type: Species
initial concentration: NaN
has only substance units: false
name: B3GALT5

http://identifiers.org/biomodels.db/MODEL1310110026#_170f9f02_4fa4_4632_89a3_0e6a2b4faaf4
is: SBO:0000252
type: Species
constant: false
name: AK4
is encoded by: hsa:205
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR NACHEXA20ly
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
reactant: MODEL1310110026#
modifier: MODEL1310110026#
type: Reaction
product: MODEL1310110026#
kinetic law: MODEL1310110026#
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase A, lysosomal
reversible: false
is: SBO:0000176

metaM 4abutn m
type: Species
is: CHEBI:58264
is: SBO:0000247
has only substance units: false
name: 4-ammoniobutanal
boundary condition: false
initial amount: NaN
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
constant: false
is: HMDB01080
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110026#_5590a24f_f19f_41a3_9f54_475af4e6e7b9
is encoded by: hsa:33
has only substance units: false
is: P28330
is: SBO:0000252
name: ACADL
boundary condition: true
initial concentration: NaN
type: Species
constant: false
initial amount: NaN

metaM HC02202 e
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:57398
name: prostaglandin A1(1-)
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

metaM glgchlo e
name: beta glucan-glycocholate complex
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C1200026H2200043NO1100006 CHARGE: 0
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: HMDB00725

metaR 5AOPtm
kinetic law: MODEL1310110026#
fast: false
product: MODEL1310110026#
name: 5-Aminolevulinate mitochondrial transport
reversible: true
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10558864 NOTES:NCD. Delta-aminolevulinic acid is produced in mitochondria then converted to PBG in the cytoplasm. Could not find anything on the transporter itself.
is described by: ECO:0000134
type: Reaction
is: SBO:0000185

metaR EX tetpent6 LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosapentaenoic acid, n-6 exchange
type: Reaction

metaM sbt D e
has only substance units: false
constant: false
name: D-glucitol
initial concentration: 1.0
type: Species
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB00247

http://identifiers.org/biomodels.db/MODEL1310110026#_6591e830_5091_4c39_835b_189f553fa2dc
is: P19440
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
name: GGT1
is encoded by: hsa:2678
is: SBO:0000252
boundary condition: true

metaM thym c
initial amount: NaN
is: HMDB00262
is: C00178
is: SBO:0000247
constant: false
has only substance units: false
name: Thymine
is: CHEBI:17821
notes: FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
type: Species
boundary condition: false
initial concentration: 1.0

metaR SERDGLNexR
modifier: MODEL1310110026#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
name: D-Serine/Glutamine reversible exchange
fast: false
kinetic law: MODEL1310110026#
product: MODEL1310110026#
is described by: ECO:0000304
reactant: MODEL1310110026#
is: SBO:0000185

metaM fum m
is: SBO:0000247
is: CHEBI:29806
initial concentration: 1.0
has only substance units: false
is: C00122
is: HMDB00134
type: Species
boundary condition: false
name: Fumarate
initial amount: NaN
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
constant: false

metaR GPIAT
product: MODEL1310110026#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (284098.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14517336 NOTES:EC 2.3.-.- NCD
modifier: MODEL1310110026#
reactant: MODEL1310110026#
fast: false
kinetic law: MODEL1310110026#
name: glucosaminylphosphatidyl inositol acetyltransferase

http://identifiers.org/biomodels.db/MODEL1310110026#_da3d11d3_db1b_4b5b_a893_c4cf222ae150
type: Species
boundary condition: true
initial concentration: NaN
is: Q9UGH3
initial amount: NaN
constant: false
is encoded by: hsa:9962
is: SBO:0000252
has only substance units: false
name: SLC23A2

http://identifiers.org/biomodels.db/MODEL1310110026#_35a0c0c1_aa43_4f41_a26a_b6e220745f26
initial amount: NaN
boundary condition: true
type: Species
is: Q9H008
is encoded by: hsa:64077
constant: false
has only substance units: false
name: LHPP
is: SBO:0000252
initial concentration: NaN

metaM oagd3 hs c
is: CHEBI:17315
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
is: C00329
name: 9-O-Acetylated GD3
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
is: HMDB01514

metaM o2 e
constant: false
is: HMDB01377
is: C00007
is: CHEBI:15379
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
name: O2
initial concentration: 1.0
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial amount: NaN

metaR PI34P5K
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
reactant: MODEL1310110026#
modifier: MODEL1310110026#
fast: false
kinetic law: MODEL1310110026#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.68
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110026#

metaM cmpacna g
initial concentration: 1.0
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
type: Species
name: CMP-N-acetyl-beta-neuraminate(2-)
is: HMDB01176
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:57812
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_2c155801_8ac9_4abb_9c86_6dec3459117c
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3284
type: Species
name: HSD3B2
constant: false
is: P26439
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_29a63125_a283_45cb_b4fe_6d08b3516543
is: SBO:0000252
boundary condition: true
name: PDE9A
constant: false
is encoded by: hsa:5152
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false

metaR DESAT18 10
name: fatty acyl-CoA desaturase (n-C18:2CoA -> n-C18:3CoA)
kinetic law: MODEL1310110026#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
fast: false
reversible: false
reactant: MODEL1310110026#
product: MODEL1310110026#
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ

metaR HBZOPT10m
name: Hydroxybenzoate Decaprenyltransferase
is: SBO:0000176
reactant: MODEL1310110026#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (27235.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:15153069,PMID:1965190,PMID:7380842 NOTES:Used to make Ubiquinone-10 EC 2.5.1.- IT
reversible: false
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.5.1.39
product: MODEL1310110026#
fast: false
kinetic law: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_d762985b_c6c8_476c_9429_edc1f33431e1
initial amount: NaN
name: FOLR1
is encoded by: hsa:2348
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_adebd3e9_874b_4984_af9e_227763815fc8
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: PCCA
type: Species
is encoded by: hsa:5095
is: C9JPQ8
constant: false

metaM udpglcur c
is: CHEBI:58052
is: SBO:0000247
boundary condition: false
type: Species
is: C00167
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB00935
initial amount: NaN
name: UDP-D-glucuronate
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167

metaM i e
initial concentration: 1.0
is: CHEBI:16382
name: iodide
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB12238
initial amount: NaN
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
boundary condition: false
type: Species

metaR r0968
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
name: Postulated transport reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
reversible: false
type: Reaction
product: MODEL1310110026#
is described by: ECO:0000000

metaR FATP8t
type: Reaction
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
is described by: ECO:0000269
product: MODEL1310110026#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty acid electroneutral transport
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
is: SBO:0000185
reactant: MODEL1310110026#
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.7

metaM glyald c
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
is: CHEBI:17378
initial amount: NaN
type: Species
constant: false
name: D-Glyceraldehyde
has only substance units: false
is: C00577
is: HMDB01051
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaM i c
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
type: Species
is: CHEBI:16382
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
name: iodide
initial amount: NaN
is: HMDB12238

metaM lac D e
initial amount: NaN
constant: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
type: Species
boundary condition: false
is: HMDB01311
name: (R)-lactate
has only substance units: false
is: SBO:0000247
is: CHEBI:16004
initial concentration: 1.0

metaM e4hglu m
boundary condition: false
is: CHEBI:6331
type: Species
constant: false
initial concentration: 1.0
is: HMDB02273
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947
initial amount: NaN
has only substance units: false
name: erythro-4-hydroxy-L-glutamate(1-)
is: SBO:0000247

metaM 6dhf l
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
name: hexaglutamyl folate (DHF)
is: HMDB06563
boundary condition: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110026#_9c4b462d_9478_4b36_824e_3c07ed80269b
type: Species
initial concentration: NaN
is: SBO:0000252
is: Q02218
name: OGDH
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:4967

http://identifiers.org/biomodels.db/MODEL1310110026#_8743c480_767f_4ad7_aca9_c889cb0f0e22
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
is: B3KXK1
type: Species
is encoded by: hsa:115019
initial amount: NaN
name: SLC26A9

metaM adpac x
boundary condition: false
is: HMDB00448
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: adipic acid
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C6H8O4 CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110026#_488e918b_1c32_48ff_b36e_73c7ef045673
is: SBO:0000252
is encoded by: hsa:4712
constant: false
boundary condition: true
has only substance units: false
is: O95139
name: NDUFB6
initial concentration: NaN
initial amount: NaN
type: Species

metaM trp L c
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16828
is: HMDB00929
boundary condition: false
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
initial amount: NaN
name: L-tryptophan
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_5a298710_e403_4770_a732_a00b2f00376e
boundary condition: true
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:10449
is: SBO:0000252
has only substance units: false
name: ACAA2
is: P42765
initial concentration: NaN

metaM o2 c
initial amount: NaN
is: CHEBI:15379
is: C00007
type: Species
is: SBO:0000247
name: O2
is: HMDB01377
initial concentration: 1.0
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
has only substance units: false
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110026#_8d2d9a26_3018_42c3_b161_29dc3d524da3
has part: D6RDW3
is encoded by: hsa:2982
type: Species
constant: false
is: SBO:0000297
name: GUCY1B2:GUCY1A3
initial concentration: NaN
is encoded by: hsa:2974
boundary condition: true
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_fdc999c5_94e0_4bc0_af7a_95249cbcdf1c
is: P48448
is encoded by: hsa:222
name: ALDH3B2
boundary condition: true
type: Species
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR AG13T5g
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false
fast: false
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
type: Reaction
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
reactant: MODEL1310110026#

metaR PYNP2r
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2
type: Reaction
name: pyrimidine-nucleoside phosphorylase (uracil)
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.3
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110026#
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
fast: false
product: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_4d1466a5_1bb3_44fb_a089_e0a7c0b75c83
is encoded by: hsa:30
initial amount: NaN
constant: false
name: ACAA1
initial concentration: NaN
is: Q96CA6
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252

metaM 6dhf m
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB06563
has only substance units: false
type: Species
name: hexaglutamyl folate (DHF)
is: SBO:0000247

metaM 3dphb m
notes: FORMULA: C57H85O3 CHARGE: -1 INCHI: InChI=1/C57H86O3/c1-44(2)21-12-22-45(3)23-13-24-46(4)25-14-26-47(5)27-15-28-48(6)29-16-30-49(7)31-17-32-50(8)33-18-34-51(9)35-19-36-52(10)37-20-38-53(11)39-40-54-43-55(57(59)60)41-42-56(54)58/h21,23,25,27,29,31,33,35,37,39,41-43,58H,12-20,22,24,26,28,30,32,34,36,38,40H2,1-11H3,(H,59,60)/b45-23+,46-25+,47-27+,48-29+,49-31+,50-33+,51-35+,52-37+,53-39+
initial amount: NaN
type: Species
constant: false
is: HMDB06251
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
name: 3-Decaprenyl-4-hydroxybenzoate

metaR AG13T17g
is described by: ECO:0000000
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
product: MODEL1310110026#
modifier: MODEL1310110026#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
reversible: false
is: SBO:0000176

metaR GLYSNAT5tc
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_1a3972b6_6024_4ef1_8d14_5d08cdb0b9a5
is encoded by: hsa:6120
type: Species
initial concentration: NaN
is: Q53TV9
constant: false
is: SBO:0000252
initial amount: NaN
name: RPE
boundary condition: true
has only substance units: false

metaM malthp e
initial amount: NaN
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
is: http://identifiers.org/pubchem.compound/5041
constant: false
is: SBO:0000247
name: maltoheptaose
is: C01936
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaR GALASE20ly
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
reversible: false
product: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: beta-galactosidase, lysosomal
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_95839e84_7e51_4243_b2c3_300fa4e4d89c
initial amount: NaN
type: Species
constant: false
name: ATP10A
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:57194
is: O60312

metaR r0410
fast: false
is: SBO:0000176
product: MODEL1310110026#
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
kinetic law: MODEL1310110026#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
type: Reaction
reversible: true
reactant: MODEL1310110026#

metaR RE2799C
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110026#
is: SBO:0000176
reversible: true
reactant: MODEL1310110026#
type: Reaction
name: RE2799
product: MODEL1310110026#

metaM lac D c
initial amount: NaN
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
constant: false
boundary condition: false
name: (R)-lactate
is: HMDB01311
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:16004

metaM ksi deg1 l
is: HMDB00174
name: keratan sulfate I, degradation product 1
is: CHEBI:18287
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
constant: false
boundary condition: false

metaR GLUt7l
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
is described by: ECO:0000000
type: Reaction
fast: false
name: Glutamate transport, lysosomal
is: SBO:0000185
reversible: false
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_edc0b2ed_f47a_4b69_a33f_549ad9998b5c
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:197258
is: SBO:0000252
name: FUK
is: Q8N0W3

metaR EX tetdece1crn
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecenoyl carnitine
type: Reaction

metaM mlthf c
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
name: 5,10-Methylenetetrahydrofolate
boundary condition: false
is: CHEBI:15636
constant: false
is: HMDB01533
is: C00143

metaM cmpacna c
initial amount: NaN
is: HMDB01176
is: SBO:0000247
is: CHEBI:57812
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: CMP-N-acetyl-beta-neuraminate(2-)
constant: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_bb93a1ea_2225_4747_aaad_9e7a8232e748
initial concentration: NaN
name: GBA
initial amount: NaN
constant: false
is encoded by: hsa:2629
boundary condition: true
is: B7Z6S1
has only substance units: false
is: SBO:0000252
type: Species

metaR NADHtru
reversible: false
reactant: MODEL1310110026#
fast: false
kinetic law: MODEL1310110026#
product: MODEL1310110026#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
is: SBO:0000185
name: NADH transporter, endoplasmic reticulum

metaR EX dgsn LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyguanosine
type: Reaction

metaR LEUt5m
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110026#
product: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
name: leucine mitochondrial transport
fast: false

metaR r0963
is: SBO:0000185
name: Facilitated diffusion
kinetic law: MODEL1310110026#
reversible: false
product: MODEL1310110026#
fast: false
reactant: MODEL1310110026#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
is described by: ECO:0000000

metaM nadh r
has only substance units: false
boundary condition: false
constant: false
is: HMDB01487
initial concentration: 1.0
name: NADH(2-)
is: SBO:0000247
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
is: CHEBI:57945
type: Species
initial amount: NaN

metaR DNDPt27m
modifier: MODEL1310110026#
is described by: ECO:0000269
fast: false
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110026#
name: dCDP transport via dTDP antiport
type: Reaction
is: SBO:0000185
reversible: false
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_63b90f37_d400_4fdc_a418_139dbe8fd4a4
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:1633
name: DCK
is: P27707
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110026#_f5df7665_e2b2_4bf2_95ba_c821c201b163
boundary condition: true
is encoded by: hsa:4718
initial amount: NaN
name: NDUFC2
has only substance units: false
type: Species
constant: false
is: Q549M5
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110026#_b991af53_ca2e_4cc4_a040_a08c6f5d69e9
type: Species
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: ALOX5
is encoded by: hsa:240
boundary condition: true
is: P09917

http://identifiers.org/biomodels.db/MODEL1310110026#_1d08ead6_178f_4be0_b037_e8b83b322e03
is: SBO:0000252
boundary condition: true
is encoded by: hsa:29925
type: Species
name: GMPPB
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_d5d9e156_5d2d_49ba_8467_0fc1a7ce8927
type: Species
initial concentration: NaN
is: SBO:0000252
is: Q9GZX3
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:4166
name: CHST6

metaR EX din LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyinosine
type: Reaction

metaM tethex3coa c
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C45H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4,7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38?,39-,40+,44-/m1/s1
is: HMDB06243
name: tetracosahexaenoyl coenzyme A
is: C16168
is: http://identifiers.org/pubchem.compound/47205478
constant: false

metaR r0962
type: Reaction
kinetic law: MODEL1310110026#
is described by: ECO:0000000
reversible: false
product: MODEL1310110026#
fast: false
reactant: MODEL1310110026#
is: SBO:0000185
name: Facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110026#_4e2046ca_4b7a_421f_9058_72f67b32e10f
name: PDE2A
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:5138
initial amount: NaN
is: Q8IW54
constant: false
type: Species
is: SBO:0000252

metaR ADKd
modifier: MODEL1310110026#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.3
product: MODEL1310110026#
name: adenylate kinase (d form)
type: Reaction
kinetic law: MODEL1310110026#
reversible: true
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)
fast: false
is: SBO:0000176
reactant: MODEL1310110026#

metaM cs e deg1 l
is: CHEBI:57737
constant: false
has only substance units: false
initial amount: NaN
is: HMDB00868
initial concentration: 1.0
notes: FORMULA: C45H65N2O52S5 CHARGE: -7
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 1
is: SBO:0000247
type: Species
boundary condition: false

metaM pect e
boundary condition: false
is: HMDB03402
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
type: Species
notes: FORMULA: C2535H3509O2535 CHARGE: -1
name: pectins

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_0aa5cb4c_7ede_47a7_b6f8_85384a32f5ab
is: SBO:0000252
constant: false
is: B7Z2M9
initial concentration: NaN
is encoded by: hsa:8525
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
name: DGKZ

http://identifiers.org/biomodels.db/MODEL1310110026#_aafbe924_9bdf_493c_9671_45f5971b03ce
boundary condition: true
constant: false
is: Q9Y6T7
type: Species
is encoded by: hsa:1607
has only substance units: false
initial concentration: NaN
name: DGKB
is: SBO:0000252
initial amount: NaN

metaR RE1526M
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
fast: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
name: RE1526
reactant: MODEL1310110026#
reversible: true
modifier: MODEL1310110026#
product: MODEL1310110026#

metaR GAL3ST11
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
is described by: ECO:0000000
modifier: MODEL1310110026#
reversible: false
fast: false
name: Galactosylceramide sulfotransferase
notes: GENE_ASSOCIATION: (9514.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 4 AUTHORS: PMID:9030544 NOTES:NJ
is: SBO:0000176
type: Reaction
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.8.2.11

metaM leuktrE4 e
name: leukotriene E4(1-)
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:57462
has only substance units: false
constant: false
is: HMDB02200
initial amount: NaN
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952

metaR SUCCACT
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of succinate
type: Reaction

metaM guln c
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
name: L-gulonate
has only substance units: false
initial amount: NaN
constant: false
is: HMDB03290
is: SBO:0000247
is: CHEBI:13115

metaM gthrd e
is: CHEBI:57925
name: glutathionate(1-)
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB00125

metaR r0960
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110026#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
product: MODEL1310110026#
reactant: MODEL1310110026#
type: Reaction

metaM 5fthf m
type: Species
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
name: 5-formyltetrahydrofolate(2-)
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
is: HMDB01562
has only substance units: false
is: SBO:0000247
is: CHEBI:57457

metaM 5oxpro e
constant: false
name: 5-oxoprolinate
is: SBO:0000247
is: CHEBI:57606
type: Species
initial amount: NaN
is: HMDB00267
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1

http://identifiers.org/biomodels.db/MODEL1310110026#_e60e6379_a213_42ff_b5b6_85d9b91ca90d
is: SBO:0000252
initial concentration: NaN
name: SLC33A1
has only substance units: false
constant: false
boundary condition: true
is: O00400
initial amount: NaN
is encoded by: hsa:9197
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_4bf1fe67_7f86_40e1_954f_2c7d51d580da
has only substance units: false
initial amount: NaN
is encoded by: hsa:79143
name: MBOAT7
is: SBO:0000252
is: Q96N66
boundary condition: true
type: Species
initial concentration: NaN
constant: false

metaR GAL3ST12
notes: GENE_ASSOCIATION: (9514.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 4 AUTHORS: PMID:9030544 NOTES:NJ
reversible: false
name: Galactosylceramide sulfotransferase
is described by: ECO:0000269
modifier: MODEL1310110026#
reactant: MODEL1310110026#
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.8.2.11
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110026#
fast: false

metaR RE3272N
type: Reaction
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
is: SBO:0000176
name: RE3272
kinetic law: MODEL1310110026#
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110026#

metaM o2 m
is: HMDB01377
initial concentration: 1.0
has only substance units: false
is: CHEBI:15379
type: Species
is: SBO:0000247
initial amount: NaN
is: C00007
name: O2
boundary condition: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
constant: false

metaM 5oxpro c
is: CHEBI:57606
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB00267
initial amount: NaN
type: Species
name: 5-oxoprolinate
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00856 EHMN_ABBREVIATION: C01879
has only substance units: false
initial concentration: 1.0

metaM HC00822 l
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: Chitobiose
is: SBO:0000247
notes: FORMULA: C16H28N2O11 CHARGE: 0 INCHI: InChI=1S/C16H28N2O11/c1-5(21)17-9-13(25)14(8(4-20)27-15(9)26)29-16-10(18-6(2)22)12(24)11(23)7(3-19)28-16/h7-16,19-20,23-26H,3-4H2,1-2H3,(H,17,21)(H,18,22)/t7-,8-,9-,10-,11-,12-,13-,14-,15?,16+/m1/s1 EHMN_ABBREVIATION: C01674
is: CHEBI:28681
constant: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_2cead392_d6af_40ab_9f40_864ea3277c4d
is encoded by: hsa:3422
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
type: Species
name: IDI1
is: SBO:0000252
is: Q13907

metaR EX btn LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biotin exchange
type: Reaction

metaM dgdp n
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:58595
constant: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: HMDB00960
name: dGDP(2-)

metaR RDH3
product: MODEL1310110026#
fast: false
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368 NOTES:IT
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.315
modifier: MODEL1310110026#
reversible: true
name: retinol dehydrogenase (11-cis,NADH)
reactant: MODEL1310110026#

metaM glyald m
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:17378
has only substance units: false
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
initial amount: NaN
is: SBO:0000247
is: HMDB01051
name: D-glyceraldehyde

http://identifiers.org/biomodels.db/MODEL1310110026#_6cb5eda3_822a_4500_830b_27b4910911ff
boundary condition: true
name: _F23536_1_m
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:F23536
initial concentration: NaN
type: Species

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

metaR GALASE9ly
kinetic law: MODEL1310110026#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
reactant: MODEL1310110026#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110026#
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
modifier: MODEL1310110026#

metaM cmpacna n
is: SBO:0000247
type: Species
name: CMP-N-acetyl-beta-neuraminate(2-)
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: CHEBI:57812
initial amount: NaN
is: HMDB01176

metaR CYSGLTH
is: SBO:0000176
type: Reaction
name: Glutathione:cystine oxidoreductase
kinetic law: MODEL1310110026#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
fast: false
reactant: MODEL1310110026#
is described by: ECO:0000000
product: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_44370028_566a_4e67_9a98_03479e7ab9e9
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: ABCB4
type: Species
boundary condition: true
is encoded by: hsa:5244
constant: false

metaM leuktrE4 c
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:57462
is: SBO:0000247
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
constant: false
name: leukotriene E4(1-)
is: HMDB02200

metaR DITPtn
product: MODEL1310110026#
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110026#
is: SBO:0000185
reversible: true
name: dITP nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_f89fee2e_02b4_4cfd_91d0_f29c8f5d7348
boundary condition: true
is encoded by: hsa:5136
initial concentration: NaN
name: PDE1A
constant: false
is: Q9Y633
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false

metaM nadh m
type: Species
is: C00004
initial concentration: 1.0
is: HMDB01487
constant: false
is: http://identifiers.org/pubchem.compound/3306
initial amount: NaN
is: SBO:0000247
is: CHEBI:57945
has only substance units: false
boundary condition: false
name: Nicotinamide adenine dinucleotide - reduced

http://identifiers.org/biomodels.db/MODEL1310110026#_ab043113_7120_4fe8_80ee_526a5d4372f9
is encoded by: hsa:206
initial amount: NaN
type: Species
name: _206_1_c
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110026#_2942bb24_ff05_4ba5_8a6d_400f57b816b8
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
is: Q5TDP6
name: LGSN
is encoded by: hsa:51557
constant: false
type: Species

metaR FUCASE2ly
name: alpha-fucosidase, lysosomal
fast: false
reversible: false
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
type: Reaction
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.2.1.51
notes: GENE_ASSOCIATION: (2517.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:11870229,PMID:1769200,PMID:2803312,PMID:2983333 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110026#
is: SBO:0000176

metaM hista e
initial concentration: 1.0
type: Species
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
is: SBO:0000247
constant: false
has only substance units: false
name: histamium
is: CHEBI:58432
initial amount: NaN
boundary condition: false
is: HMDB00870

http://identifiers.org/biomodels.db/MODEL1310110026#_005c150a_1dbc_40c7_9686_491342934c55
boundary condition: true
is: SBO:0000252
name: _AA081045_1_m
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:AA081045

metaR RDH2
fast: false
name: retinol dehydrogenase (9-cis,NADH)
modifier: MODEL1310110026#
is: SBO:0000176
type: Reaction
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.1.1.315
is described by: ECO:0000269
kinetic law: MODEL1310110026#
reversible: true
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368,PMID:9115228 NOTES:IT
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_6a4405ce_a389_47ca_ad91_96a761978909
constant: false
name: GALNT14
has only substance units: false
is: SBO:0000252
is: Q96FL9
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:79623
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110026#_ddf27b7c_c6f4_48e3_b162_bcbfebe72fd0
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:56052
name: ALG1
initial amount: NaN
is: Q9BT22

metaM xol27oh r
boundary condition: false
name: 26-hydroxycholesterol
is: HMDB02103
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:17703
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340

metaM fadh2 m
is: C01352
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB01197
initial concentration: 1.0
name: Flavin adenine dinucleotide reduced
is: CHEBI:58307
constant: false
is: SBO:0000247

metaM dgtp c
is: HMDB01440
is: CHEBI:16497
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
type: Species
initial concentration: 1.0
name: dGTP
is: C00286
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247

metaR DASCBR
is described by: ECO:0000269
type: Reaction
product: MODEL1310110026#
is: SBO:0000176
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (2745.1) or (51022.2) or (51022.1) SUBSYSTEM: Vitamin C metabolism EC Number: 1.6.5.4 Confidence Level: 4 AUTHORS: PMID:11297543 NOTES:
is version of: http://identifiers.org/ec-code/1.8.4.1
reversible: false
fast: false
modifier: MODEL1310110026#
name: dehydroascorbate reductase

http://identifiers.org/biomodels.db/MODEL1310110026#_78be00c4_9fb9_4e38_a64c_1ec96899a479
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
name: B3GALT5
is encoded by: hsa:10317

http://identifiers.org/biomodels.db/MODEL1310110026#_2a5313a5_0413_4cc5_8a0b_ea56b785a371
constant: false
name: ADSS
boundary condition: true
is: SBO:0000252
is encoded by: hsa:159
is: P30520
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_4778c801_61bf_4e1d_915f_4c379111ee43
initial concentration: NaN
type: Species
has only substance units: false
is: Q13956
boundary condition: true
initial amount: NaN
constant: false
name: PDE6H
is encoded by: hsa:5149
is: SBO:0000252

metaR FORMCOAtx
is: SBO:0000185
name: formyl coa transport
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism see Verhoeven 11591435 and clayton 11356171 - added for peroxisomal oxidation of fatty acids NJ
reversible: true
product: MODEL1310110026#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110026#
fast: false

metaR DNDPt41m
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
product: MODEL1310110026#
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110026#
name: dUTP transport via dCDP antiport
reversible: false
reactant: MODEL1310110026#
modifier: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_03f69a3f_d076_4f66_a32c_63dc60d9a278
boundary condition: true
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:2720
is: SBO:0000252
name: GLB1
is: P16278

metaR M13N2Tg
notes: GENE_ASSOCIATION: (4245.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.101 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
name: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.4.1.101
reversible: false
type: Reaction
reactant: MODEL1310110026#
product: MODEL1310110026#
modifier: MODEL1310110026#
is described by: ECO:0000000
fast: false
is: SBO:0000176

metaR RDH1
name: retinol dehydrogenase (all-trans)
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES:IT
is described by: ECO:0000269
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
is: SBO:0000176
reactant: MODEL1310110026#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.315
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110026#_0b5cc7c4_0e73_4b2e_883c_09ec9a22e419
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
name: ALDOB
is: P05062
initial concentration: NaN
is encoded by: hsa:229

http://identifiers.org/biomodels.db/MODEL1310110026#_11270630_dddd_43f9_9e91_397330e22fbd
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is: E5KS60
is encoded by: hsa:8803
name: SUCLA2
is: SBO:0000252
initial amount: NaN

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_b46da85f_ff97_4c4a_a448_ea9d6f0ee675
type: Species
initial concentration: NaN
name: ADH7
boundary condition: true
is: P40394
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:131
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_1e2609b4_b49f_454a_b720_93cd2adc6d16
type: Species
initial concentration: NaN
has only substance units: false
constant: false
name: DGKB
initial amount: NaN
boundary condition: true
is encoded by: hsa:1607
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110026#_77377f7a_78f8_4731_b187_ccdba19d0055
is encoded by: hsa:30
is: SBO:0000252
type: Species
name: ACAA1
is: Q96CA6
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN

metaR EX ocdca LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: echange reaction for octadecanoate (n-C18:0)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_6e57f862_ed86_44c7_9cc7_fca9ead7fb9a
is: SBO:0000252
is encoded by: hsa:953
name: ENTPD1
has only substance units: false
is: Q86VV3
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
constant: false

metaM hista c
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
name: histamium
constant: false
type: Species
boundary condition: false
is: CHEBI:58432
initial concentration: 1.0
initial amount: NaN
is: HMDB00870

http://identifiers.org/biomodels.db/MODEL1310110026#_f1718b14_a204_4a68_9d82_d2ba2b46bc31
is: Q99714
initial concentration: NaN
constant: false
name: HSD17B10
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:3028

metaR CYOOm3
is version of: http://identifiers.org/ec-code/1.9.3.1
reversible: false
reactant: MODEL1310110026#
is: SBO:0000185
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
product: MODEL1310110026#
name: cytochrome c oxidase, mitochondrial Complex IV
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
type: Reaction

metaR NACHEXA16ly
modifier: MODEL1310110026#
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase A, lysosomal
reversible: false

metaM didp c
is: HMDB03536
is: CHEBI:28823
name: dIDP
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_f466b26d_bc86_482d_832f_8aa9d50a34c1
type: Species
has only substance units: false
is encoded by: hsa:29920
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: PYCR2
constant: false
boundary condition: true
is: Q96C36

metaM adrncoa c
is: http://identifiers.org/pubchem.compound/47205480
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
name: adrenyl coenzyme A
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
is: C16170
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_f9f85890_49e7_4157_b3e9_4cc235da0538
is: Q8N1Q1
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: CA13
is encoded by: hsa:377677
boundary condition: true
has only substance units: false

metaM gchola c
is: HMDB00138
is: CHEBI:58235
has only substance units: false
name: glycocholate
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
constant: false

metaM gthrd c
is: CHEBI:57925
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: C00051
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00125
has only substance units: false
boundary condition: false
initial amount: NaN
name: Reduced glutathione

http://identifiers.org/biomodels.db/MODEL1310110026#_a4bbd8a5_0dab_4e41_8c68_60d75451ffc7
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:BE966236
name: _BE966236_1_m
type: Species
constant: false

metaR DIDPtn
kinetic law: MODEL1310110026#
is described by: ECO:0000000
product: MODEL1310110026#
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110026#
name: dIDP nuclear transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110026#_bc250f76_78f4_47c4_b419_a126624bddf3
boundary condition: true
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
is: SBO:0000297
has only substance units: false
is encoded by: hsa:7991
type: Species
constant: false
initial concentration: NaN
initial amount: NaN

metaR CSPG Atly
fast: false
type: Reaction
kinetic law: MODEL1310110026#
reversible: false
product: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
is described by: ECO:0000000
name: chondroitin sulfate A transport, extracellular to lysosome

metaR r1078
fast: false
reactant: MODEL1310110026#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
name: Vesicular transport
kinetic law: MODEL1310110026#
product: MODEL1310110026#
is: SBO:0000185

metaR XOL27OHtm
reversible: true
kinetic law: MODEL1310110026#
name: 27 hydroxy cholesterol transport
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
type: Reaction
product: MODEL1310110026#
is: SBO:0000185
is described by: ECO:0000000
fast: false

metaM mi34p c
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: 1D-myo-Inositol 3,4-bisphosphate
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)4(10)6(18-20(14,15)16)5(3(1)9)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C04063
initial amount: NaN
is: CHEBI:28858
constant: false
is: SBO:0000247
is: HMDB06235
type: Species

metaR MCCCrm
kinetic law: MODEL1310110026#
type: Reaction
fast: false
reversible: true
is: SBO:0000176
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (56922.1 and 64087.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.4 Confidence Level: 4 AUTHORS: PMID:11181649,PMID:11406611 NOTES:MM
product: MODEL1310110026#
modifier: MODEL1310110026#
is described by: ECO:0000269
name: methylcrotonoyl-CoA carboxylase, mitochondrial
is version of: http://identifiers.org/ec-code/6.4.1.4

metaR GASNASEly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/3.5.1.26
name: glycosylasparaginase, lysosomal
product: MODEL1310110026#
fast: false
modifier: MODEL1310110026#
is: SBO:0000176
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
reversible: false
type: Reaction

metaM pail35p hs c
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
type: Species
boundary condition: false
constant: false
is: CHEBI:57923
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_e5856eaf_c2ab_4b1f_a76e_8a33a90d60f2
boundary condition: true
initial concentration: NaN
name: NDUFS4
initial amount: NaN
constant: false
type: Species
is: O43181
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4724

metaR LYStip
is: SBO:0000185
type: Reaction
fast: false
name: L-lysine transport, peroxisomal (irreversible)
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:6811962 NOTES:MM
product: MODEL1310110026#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110026#_8ed56367_0098_48fa_99d5_9ba738dcf6f4
is: SBO:0000252
constant: false
name: SLC26A7
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:115111

http://identifiers.org/biomodels.db/MODEL1310110026#_ec2f3d44_22f2_481f_81ff_a71948859398
constant: false
type: Species
is encoded by: hsa:1582
boundary condition: true
name: CYP8B1
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: Q9UNU6

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

metaM gchola e
is: HMDB00138
is: SBO:0000247
boundary condition: false
has only substance units: false
name: glycocholate
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C26H43NO6 CHARGE: 0

metaM gluala e
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740
initial concentration: 1.0
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/6503
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB06248
type: Species
is: C03740
name: 5-L-Glutamyl-L-alanine

metaM nadh c
is: CHEBI:57945
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3306
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
is: C00004
is: HMDB01487
name: Nicotinamide adenine dinucleotide - reduced

metaR TETTET6t
reversible: true
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
fast: false
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
name: fatty acid transport via diffusion

metaM aps c
initial amount: NaN
has only substance units: false
is: CHEBI:58243
name: 5'-adenylyl sulfate(2-)
notes: FORMULA: C10H12N5O10PS CHARGE: -2 INCHI: InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00204 EHMN_ABBREVIATION: C00224
is: SBO:0000247
is: HMDB01003
constant: false
type: Species
initial concentration: 1.0
boundary condition: false

metaM gthrd m
boundary condition: false
type: Species
is: HMDB00125
has only substance units: false
name: glutathionate(1-)
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57925
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051

metaM 20ahchsterol m
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500
is: HMDB06283
is: CHEBI:1296
has only substance units: false
constant: false
initial amount: NaN
name: 20-hydroxycholesterol

metaM ksi pre21 g
boundary condition: false
initial concentration: 1.0
is: CHEBI:58053
is: HMDB00175
initial amount: NaN
is: SBO:0000247
constant: false
is: C00130
has only substance units: false
notes: FORMULA: C177H284N12O145S6X CHARGE: -7
name: keratan sulfate I biosynthesis, precursor 21
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_9f498256_b66f_4c74_82a4_199c82cd481c
boundary condition: true
has only substance units: false
is encoded by: hsa:6555
type: Species
is: SBO:0000252
initial amount: NaN
name: SLC10A2
is: Q12908
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_828f7a90_cc64_4968_8aa3_748446059238
initial amount: NaN
type: Species
is: SBO:0000252
name: FTCD
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:10841
initial concentration: NaN

metaM 5dpmev c
initial amount: NaN
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1
initial concentration: 1.0
has only substance units: false
name: (R)-5-Diphosphomevalonate
boundary condition: false
constant: false
type: Species
is: HMDB01090
is: SBO:0000247

metaR NDPK1m
modifier: MODEL1310110026#
type: Reaction
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
fast: false
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
reversible: true
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
product: MODEL1310110026#
kinetic law: MODEL1310110026#

metaM biliverd c
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C33H32N4O6 CHARGE: -2 INCHI: InChI=1S/C33H34N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-15,35H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14-,28-15- EHMN_ABBREVIATION: C00500
name: biliverdin(2-)
boundary condition: false
is: CHEBI:57991
constant: false
is: HMDB01008
initial amount: NaN

metaM HC01609 e
type: Species
initial concentration: 1.0
is: CHEBI:28766
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
boundary condition: false
name: UroporphyrinogenI
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_0e8596f6_f3af_46b0_a6dc_2a4043a2ced6
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110026#_23780574_b66b_43e7_a142_9a340efa3438
is: A8K7J7
is encoded by: hsa:3098
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
constant: false
has only substance units: false
initial amount: NaN
name: HK1

metaM hgentis c
constant: false
name: homogentisate
boundary condition: false
is: HMDB00130
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 HEPATONET_1.0_ABBREVIATION: HC00423 EHMN_ABBREVIATION: C00544
initial amount: NaN
is: CHEBI:16169
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_5528aa04_3189_4d2e_b82d_863966693f0d
has only substance units: false
name: _AA576959_1_c
constant: false
is: SBO:0000252
is encoded by: hsa:AA576959
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN

metaR r0527
name: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
reversible: true
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110026#_6695dd94_59ff_46ea_af85_7c761ca8ac54
is: SBO:0000252
initial amount: NaN
is: O75746
constant: false
name: SLC25A12
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:8604
type: Species

metaR r0638
product: MODEL1310110026#
reactant: MODEL1310110026#
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is version of: http://identifiers.org/ec-code/2.8.1.2
reversible: true
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
fast: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_a8e873f2_5d48_43cb_8fd8_a5c21852c7aa
name: PKM2
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:5315
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110026#_46ce8ae2_8489_451d_8b86_91729432d4d7
type: Species
is: SBO:0000252
is encoded by: hsa:10935
constant: false
has only substance units: false
name: PRDX3
is: P30048
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaM pppg9 c
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB01097
is: CHEBI:57307
notes: FORMULA: C34H38N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00656 EHMN_ABBREVIATION: C01079
type: Species
is: C01079
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: Protoporphyrinogen IX

metaM m4mpdol U r
type: Species
boundary condition: false
is: SBO:0000247
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: CHEBI:37633
initial amount: NaN
constant: false
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
has only substance units: false
initial concentration: 1.0

metaR 34HPLFM
name: 3-(4-hydroxyphenyl-)lactate formation
is described by: ECO:0000000
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
type: Reaction
product: MODEL1310110026#
fast: false

metaR AHEXASE2ly
is described by: ECO:0000000
kinetic law: MODEL1310110026#
fast: false
product: MODEL1310110026#
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110026#
type: Reaction
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
is: SBO:0000176
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110026#_fed02c82_33d2_4807_be74_4fef4bf62164
type: Species
initial concentration: NaN
is encoded by: hsa:2687
has only substance units: false
is: P36269
is: SBO:0000252
name: GGT5
initial amount: NaN
constant: false
boundary condition: true

metaM CE2416 x
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:57923
type: Species
has only substance units: false
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)/p-1/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: CE2416
is: SBO:0000247
name: (2R,6S,10S)-pristanate
initial amount: NaN

metaR AGTim
product: MODEL1310110026#
kinetic law: MODEL1310110026#
is: SBO:0000176
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110026#
name: alanine-glyoxylate transaminase (irreversible), mitochondrial
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.44
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (64902.1) or (64850.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.44 Confidence Level: 4 AUTHORS: PMID:15240345,PMID:9038835,PMID:9783918 NOTES:NCD
fast: false

metaR PI45PLC
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110026#
is: SBO:0000176
modifier: MODEL1310110026#
reversible: false
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.4.11
reactant: MODEL1310110026#
product: MODEL1310110026#
fast: false
name: phosphatidylinositol 4,5-bisphosphate phospholipase C

metaR GLNS
reversible: false
fast: false
is: SBO:0000176
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: glutamine synthetase
type: Reaction
modifier: MODEL1310110026#
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/4.1.1.15
product: MODEL1310110026#
is described by: ECO:0000254

http://identifiers.org/biomodels.db/MODEL1310110026#_fb574a7b_4ad4_41b9_ae17_9827e7c2749c
constant: false
is encoded by: hsa:4723
type: Species
is: E5KNH5
initial amount: NaN
name: NDUFV1
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN

metaM focytC m
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
name: Ferrocytochrome C
is: CHEBI:16928

metaR NDPK1n
product: MODEL1310110026#
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:15242782 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
name: nucleoside-diphosphate kinase (ATP:GDP), nuclear
reversible: true
is: SBO:0000176
is described by: ECO:0000134
fast: false
type: Reaction
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_a08781be_0618_4ed6_877e_150ba96a693a
is: SBO:0000252
is encoded by: hsa:10587
initial concentration: NaN
boundary condition: true
type: Species
constant: false
has only substance units: false
name: TXNRD2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_54aedb61_45b7_4f4c_b685_66c26c6485e4
constant: false
is: P27144
initial concentration: NaN
has only substance units: false
is encoded by: hsa:205
is: SBO:0000252
boundary condition: true
type: Species
name: AK4
initial amount: NaN

metaM ethamp c
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB00224
boundary condition: false
initial amount: NaN
name: ethamp[c]
is: CHEBI:58190
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
type: Species

metaR DM Ser Gly Ala X Gly ly
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser-Gly/Ala-X-Gly(ly)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_cee43ff4_1c8f_4118_8751_5e0fcc5df8d6
is encoded by: hsa:593
is: B4DP47
constant: false
boundary condition: true
has only substance units: false
name: BCKDHA
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species

metaR RE2660N
kinetic law: MODEL1310110026#
reversible: true
name: RE2660
modifier: MODEL1310110026#
reactant: MODEL1310110026#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
is: SBO:0000176
product: MODEL1310110026#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.96

http://identifiers.org/biomodels.db/MODEL1310110026#_6d399ed9_a238_4d1a_92a0_a3836a76271e
name: MVD
initial amount: NaN
is encoded by: hsa:4597
constant: false
initial concentration: NaN
is: P53602
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_55ef72ae_a31a_4286_b5cb_507592e3fc30
has only substance units: false
constant: false
is encoded by: hsa:6487
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: ST3GAL3
is: Q5T4Y1
is: SBO:0000252

metaM sphmyln hs c
is: CHEBI:21338
is: HMDB02704
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
name: sphmyln_hs[c]
type: Species
notes: FORMULA: CHARGE: 0
has only substance units: false

metaM o2 r
constant: false
is: CHEBI:15379
is: SBO:0000247
is: HMDB01377
initial concentration: 1.0
is: C00007
type: Species
name: O2
has only substance units: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
boundary condition: false
initial amount: NaN

metaM dgtp e
has only substance units: false
constant: false
is: HMDB01440
name: dGTP
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: CHEBI:16497
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN

metaR EX c81crn
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octenoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_64c2395d_9bfe_48c0_89f1_9a81184fe8d1
has only substance units: false
is encoded by: hsa:5305
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: PIP4K2A
is: SBO:0000252
constant: false
is: P48426

metaM c5dc e
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C12H21NO6 CHARGE: 0
type: Species
name: glutaryl carnitine
initial concentration: 1.0
is: HMDB13130
boundary condition: false
initial amount: NaN

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

metaM ksii core4 pre4 g
type: Species
notes: FORMULA: C61H99N5O43X CHARGE: -1
initial concentration: 1.0
is: HMDB00175
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 4
initial amount: NaN
is: CHEBI:58053
is: C00130
constant: false
has only substance units: false
is: SBO:0000247

metaR r1156
fast: false
product: MODEL1310110026#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
reversible: true
reactant: MODEL1310110026#
type: Reaction
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
kinetic law: MODEL1310110026#

metaM mescon m
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB00749
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
name: Mesaconate
is: CHEBI:36986
initial amount: NaN
constant: false
is: SBO:0000247

metaM hexdiac r
is: HMDB00672
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C16H28O4 CHARGE: -2
constant: false
is: C08260
name: hexadecanediocacid
type: Species
is: SBO:0000247

metaR FAOXC160
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
kinetic law: MODEL1310110026#
fast: false
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110026#
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
modifier: MODEL1310110026#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110026#_59a37465_100b_4d69_8d8a_e2b01ab1301e
is encoded by: hsa:116369
initial concentration: NaN
type: Species
constant: false
boundary condition: true
name: SLC26A8
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaM vacccoa c
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h9-10,26-28,32-34,38,49-50H,4-8,11-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b10-9+/t28-,32-,33?,34+,38-/m1/s1
has only substance units: false
is: HMDB06521
type: Species
constant: false
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/9543677
initial amount: NaN
initial concentration: 1.0
name: vaccenyl coenzyme A

metaR LNLCCRNt
modifier: MODEL1310110026#
product: MODEL1310110026#
name: transport into the mitochondria (carnitine)
type: Reaction
is: SBO:0000185
reversible: false
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110026#
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110026#_ca3fdc01_1b2d_460d_9d92_13d6c15916e0
boundary condition: true
initial concentration: NaN
is: P48448
type: Species
is encoded by: hsa:222
name: ALDH3B2
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false

metaM xol27oh m
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
is: CHEBI:17703
name: 26-hydroxycholesterol
type: Species
is: HMDB02103
has only substance units: false

metaR r0639
reversible: false
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is: SBO:0000176
name: Lauroyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is described by: ECO:0000000
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110026#_9540586c_d19d_437a_aaea_78aa4c3bc05e
initial concentration: NaN
boundary condition: true
name: NDUFAB1
type: Species
initial amount: NaN
is encoded by: hsa:4706
is: SBO:0000252
constant: false
is: O14561
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_6cbd8404_e1c9_4bc3_99a2_0fe1be7e62b6
is: SBO:0000252
is encoded by: hsa:AI769281
initial amount: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
name: _AI769281_1_e

metaM o2 n
notes: FORMULA: O2 CHARGE: 0 INCHI: InChI=1S/O2/c1-2 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial amount: NaN
initial concentration: 1.0
name: dioxygen
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
type: Species
is: HMDB01377
is: CHEBI:15379

http://identifiers.org/biomodels.db/MODEL1310110026#_d0e60bc7_789c_4d2e_ad7a_644ddd93971f
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:1349
boundary condition: true
constant: false
is: P24311
name: COX7B
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_b4ec7d91_8bf3_4ddc_93e6_c73e95fa50b2
is encoded by: hsa:4541
initial concentration: NaN
name: ND6
constant: false
initial amount: NaN
is: Q7GXZ1
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252

metaM air c
is: HMDB01235
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:58592
constant: false
notes: FORMULA: C8H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01108 EHMN_ABBREVIATION: C03373
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole
boundary condition: false
is: C03373
initial concentration: 1.0
type: Species

metaR MI3PP
name: myo-inositol 3-phosphatase
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.3.25
product: MODEL1310110026#
reversible: false
fast: false
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110026#
reactant: MODEL1310110026#

metaM udpglcur r
constant: false
is: C00167
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
is: SBO:0000247
is: CHEBI:58052
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: UDP-D-glucuronate
is: HMDB00935
boundary condition: false
type: Species

metaM 2dp6mep m
has only substance units: false
initial concentration: 1.0
name: 2-Decaprenyl-6-methoxyphenol
type: Species
is: CHEBI:50774
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C57H88O2 CHARGE: 0 INCHI: InChI=1S/C57H88O2/c1-45(2)23-13-24-46(3)25-14-26-47(4)27-15-28-48(5)29-16-30-49(6)31-17-32-50(7)33-18-34-51(8)35-19-36-52(9)37-20-38-53(10)39-21-40-54(11)43-44-55-41-22-42-56(59-12)57(55)58/h22-23,25,27,29,31,33,35,37,39,41-43,58H,13-21,24,26,28,30,32,34,36,38,40,44H2,1-12H3/b46-25+,47-27+,48-29+,49-31+,50-33+,51-35+,52-37+,53-39+,54-43+
is: SBO:0000247

metaM HC01406 m
initial concentration: 1.0
name: 3-Oxooctanoyl-CoA
boundary condition: false
type: Species
constant: false
is: CHEBI:28264
initial amount: NaN
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267
is: SBO:0000247
has only substance units: false

metaM c5dc c
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: glutaryl carnitine
notes: FORMULA: C12H21NO6 CHARGE: 0
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB13130

metaM HC01399 m
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C35H58N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-24,28-30,34,43,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t23-,24+,28+,29+,30-,34+/m0/s1 EHMN_ABBREVIATION: C05260
is: SBO:0000247
name: (S)-3-Hydroxytetradecanoyl-CoA
type: Species
is: CHEBI:27466

metaM ipdp x
is: CHEBI:128769
is: HMDB01347
name: isopentenyl diphosphate(3-)
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_e63d89f3_9d56_49ea_9dcd_3df208a7e8ea
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
has only substance units: false
is: Q9NY64
name: SLC2A8
is encoded by: hsa:29988

metaM tmndnccoa c
constant: false
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
name: timnodonyl coenzyme A
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB06514
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_61acd890_243a_48f5_a9eb_a9aee79ec3b2
is: SBO:0000252
name: BPNT1
initial amount: NaN
has only substance units: false
is: O95861
is encoded by: hsa:10380
boundary condition: true
initial concentration: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_79c49331_5391_42c9_9df4_26234f5765cc
initial concentration: NaN
type: Species
boundary condition: true
is: Q14032
initial amount: NaN
name: BAAT
is encoded by: hsa:570
constant: false
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_66d1f7a9_7c9a_4dd7_8ec2_3d6c57398290
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
name: LPGAT1
is: Q92604
is encoded by: hsa:9926
boundary condition: true
has only substance units: false
initial amount: NaN

metaR NACHEX25ly
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
type: Reaction
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110026#
is: SBO:0000176
reversible: false
modifier: MODEL1310110026#
is described by: ECO:0000000

metaR r2378
product: MODEL1310110026#
is: SBO:0000185
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110026#
reversible: true

metaR HISyLATthc
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: Transport of Histidine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

metaR SQLSr
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
type: Reaction
fast: false
is described by: ECO:0000134
reversible: false
is version of: http://identifiers.org/ec-code/2.5.1.21
reactant: MODEL1310110026#
is: SBO:0000176
name: Squalene synthase
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ
product: MODEL1310110026#

metaR FACOAL226
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110026#
is: SBO:0000176
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: true
name: fatty-acid--CoA ligase
fast: false

metaR r0021
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
is described by: ECO:0000000
product: MODEL1310110026#
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.6.1.5
fast: false
reversible: true
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110026#_0fbdbdea_978f_4d10_986d_eb34b45f5ebf
boundary condition: true
initial concentration: NaN
name: AGXT2L1
is encoded by: hsa:64850
initial amount: NaN
is: Q8TBG4
constant: false
is: SBO:0000252
type: Species
has only substance units: false

metaR AMPtp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110026#
reversible: true
kinetic law: MODEL1310110026#
product: MODEL1310110026#
name: AMP transporter, peroxisome
fast: false
is: SBO:0000185

metaR r0170
type: Reaction
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
reversible: true
product: MODEL1310110026#
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.7.1.40
is described by: ECO:0000000
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
fast: false
is: SBO:0000176

metaM idp n
name: IDP(3-)
constant: false
is: CHEBI:58280
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
initial concentration: 1.0
is: HMDB03335

metaR NAGLCAly
type: Reaction
name: N-acetylglucosaminidase, lysosomal
reactant: MODEL1310110026#
fast: false
reversible: false
kinetic law: MODEL1310110026#
is: SBO:0000176
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 1 AUTHORS: NOTES:EC 3.2.1.- This reaction is my best guess at how the GlcNAc-beta-1,6-GalNAc linkage is cleaved. NCD
is described by: ECO:0000000

metaR r0423
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
product: MODEL1310110026#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110026#
reversible: true
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
type: Reaction

metaM CE5117 m
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117
has only substance units: false
is: CHEBI:57923
constant: false
boundary condition: false
type: Species
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110026#_7d54bb10_0cee_46ea_9db6_4e2502817f2b
name: SLC25A4
is: P12235
initial amount: NaN
is encoded by: hsa:291
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR FAOXC260240x
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 30.1 and 1962.1) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c26:0 -> c24:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 -> into pmtcoa NJ
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: false
fast: false
type: Reaction
reactant: MODEL1310110026#
is: SBO:0000176
name: Beta oxidation of long chain fatty acid
is described by: ECO:0000000
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
product: MODEL1310110026#

metaR r2379
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110026#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110026#
is: SBO:0000185
reversible: true

metaM met L c
has only substance units: false
is: HMDB00696
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
boundary condition: false
initial concentration: 1.0
type: Species
name: L-methionine
is: CHEBI:16643
initial amount: NaN
is: SBO:0000247
constant: false

metaM digalsgalside hs e
is: C06127
constant: false
initial amount: NaN
notes: FORMULA: C30H55NO15SFULLRCO CHARGE: -1 EHMN_ABBREVIATION: C06127
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
name: Digalactosylceramidesulfate
is: http://identifiers.org/pubchem.compound/8384
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_c684bac0_b44f_4154_ad26_6b76efc3212d
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: P04179
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:6648
constant: false
name: SOD2

http://identifiers.org/biomodels.db/MODEL1310110026#_4022020e_e9f5_47a0_a6ae_57005b9599b1
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6184
is: P04843
boundary condition: true
name: RPN1
has only substance units: false

metaR r0022
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
fast: false
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.8.1.7
reversible: true
product: MODEL1310110026#
type: Reaction
reactant: MODEL1310110026#
is: SBO:0000176
modifier: MODEL1310110026#
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
is described by: ECO:0000000

metaM cbasp e
boundary condition: false
name: N-Carbamoyl-L-aspartate
is: SBO:0000247
type: Species
is: CHEBI:32814
has only substance units: false
initial amount: NaN
is: HMDB00828
is: C00438
initial concentration: 1.0
constant: false
notes: FORMULA: C5H6N2O5 CHARGE: -2

metaR NDPK7n
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110026#
is described by: ECO:0000304
reversible: true
modifier: MODEL1310110026#
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
product: MODEL1310110026#
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.7.4.6

metaM T4hcinnm m
initial amount: NaN
type: Species
has only substance units: false
name: trans-4-coumarate
notes: FORMULA: C9H7O3 CHARGE: -1 INCHI: InChI=1S/C9H8O3/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6,10H,(H,11,12)/p-1/b6-3+ EHMN_ABBREVIATION: C00811
is: SBO:0000247
is: HMDB02035
initial concentration: 1.0
constant: false
is: CHEBI:12876
boundary condition: false

metaR RE2814R
type: Reaction
product: MODEL1310110026#
is: SBO:0000176
reversible: true
fast: false
name: RE2814
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#

metaR G12MT1 U
kinetic law: MODEL1310110026#
is: SBO:0000176
reversible: false
reactant: MODEL1310110026#
name: Glycolipid 1,2-alpha-D-mannosyltransferase (uterus)
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
fast: false
product: MODEL1310110026#

metaR r0424
reactant: MODEL1310110026#
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
is described by: ECO:0000000
is: SBO:0000176
reversible: true
fast: false
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
type: Reaction
kinetic law: MODEL1310110026#
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.17.1.4

metaM ksi pre32 g
is: CHEBI:28067
type: Species
notes: FORMULA: C227H362N16O192S10X CHARGE: -11
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 32
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247

metaR r2376
product: MODEL1310110026#
fast: false
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110026#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110026#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110026#_e96eaacb_794a_45fe_9141_4eb3d2e27c2a
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:10965
is: P49753
type: Species
name: ACOT2
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR FACOAL224
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is: SBO:0000176
reversible: true
name: fatty-acid--CoA ligase
fast: false

metaM digalsgalside hs g
name: Digalactosylceramidesulfate
has only substance units: false
constant: false
initial amount: NaN
is: C06127
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C30H55NO15SFULLRCO CHARGE: -1 EHMN_ABBREVIATION: C06127
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/8384

metaM prostgi2 r
initial amount: NaN
boundary condition: false
is: HMDB01335
has only substance units: false
is: CHEBI:57403
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
name: prostaglandin I2(1-)
constant: false
type: Species
initial concentration: 1.0

metaR r2377
reversible: true
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
product: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_31410633_4d93_498d_b971_6ba3e346d6b2
initial concentration: NaN
name: _AI971036_1_m
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:AI971036
boundary condition: true

metaM cbasp c
notes: FORMULA: C5H6N2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00356 EHMN_ABBREVIATION: C00438
boundary condition: false
constant: false
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:32814
initial amount: NaN
is: HMDB00828
initial concentration: 1.0
is: C00438
name: N-Carbamoyl-L-aspartate

metaR EX dcsptn1 LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: docosa-4,7,10,13,16-pentaenoic acid (n-6) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_5b3e189b_1750_4a50_8aca_7b270a1fa8c4
is encoded by: hsa:522
is encoded by: hsa:516
is encoded by: hsa:515
type: Species
is encoded by: hsa:10632
is encoded by: hsa:521
has part: P05496
has part: P46459
boundary condition: true
is: SBO:0000297
is encoded by: hsa:4905
is encoded by: hsa:10476
initial amount: NaN
has only substance units: false
has part: Q6IBB3
name: ATP5H:ATP5L:NSF:ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
initial concentration: NaN
has part: O75964
has part: Q08ET0
has part: P56385
constant: false
is encoded by: hsa:9551
has part: A0PJH2

metaR DHCRD1
type: Reaction
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
name: dihydroceramide desaturase
reactant: MODEL1310110026#
is: SBO:0000176
reversible: false
product: MODEL1310110026#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ

metaR HMBS
product: MODEL1310110026#
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.5.1.61
is described by: ECO:0000254
reactant: MODEL1310110026#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (3145.1) SUBSYSTEM: Heme synthesis EC Number: 4.3.1.8 Confidence Level: 2 AUTHORS: PMID:2875434 NOTES:
type: Reaction
name: hydroxymethylbilane synthase
modifier: MODEL1310110026#
is: SBO:0000176

metaR r0173
reversible: true
kinetic law: MODEL1310110026#
product: MODEL1310110026#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3704.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:12042361,PMID:17045662,PMID:7449128,PMID:9927705 NOTES:
name: (S)-Lactate:NAD+ oxidoreductase Glycolysis / Gluconeogenesis / Pyruvate metabolism EC:1.1.1.27
is version of: http://identifiers.org/ec-code/3.6.1.19
reactant: MODEL1310110026#
is: SBO:0000176
modifier: MODEL1310110026#
fast: false
type: Reaction

metaR r0575
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.48
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
is described by: ECO:0000000
product: MODEL1310110026#

metaM HC00591 m
name: 2-oxoglutaramate
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
is: CHEBI:16769

metaM m8masn r
constant: false
boundary condition: false
initial concentration: 1.0
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: SBO:0000247
type: Species
has only substance units: false
is: C05876
notes: FORMULA: C70H117N2O55X CHARGE: 0
initial amount: NaN

metaM cl e
initial concentration: 1.0
is: C00115
is: SBO:0000247
constant: false
notes: FORMULA: Cl CHARGE: -1
has only substance units: false
is: CHEBI:3966
boundary condition: false
type: Species
name: Chloride
initial amount: NaN
is: HMDB00492

metaM pail45p hs m
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: phosphatidylinositol 4,5-bisphosphate
is: CHEBI:28910
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
is: SBO:0000247
has only substance units: false

metaR ACGALK
name: N-acetylgalactosamine kinase
reversible: false
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
type: Reaction
reactant: MODEL1310110026#
is: SBO:0000176
product: MODEL1310110026#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110026#_2b27b6d7_2a64_4859_a185_1325d0f45427
name: ADCY9
is encoded by: hsa:115
type: Species
is: SBO:0000252
is: O60503
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false

metaM gacpail hs c
is: CHEBI:61548
constant: false
name: glucosaminyl-acylphosphatidylinositol
initial concentration: 1.0
is: C00092
boundary condition: false
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN
type: Species
is: HMDB01401
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_d8b00520_7717_4975_949a_3929dcf5a935
constant: false
is encoded by: hsa:11046
initial concentration: NaN
type: Species
name: SLC35D2
initial amount: NaN
is: Q76EJ3
is: SBO:0000252
has only substance units: false
boundary condition: true

metaM atp x
type: Species
name: ATP(4-)
is: CHEBI:57299
is: C00002
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB00538

metaR RE2814M
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110026#
type: Reaction
product: MODEL1310110026#
name: RE2814
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
kinetic law: MODEL1310110026#

metaM HC00319 m
type: Species
has only substance units: false
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
is: CHEBI:30794
name: Malonate
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110026#_58b7c3d5_26d5_4490_afb4_95233a2978c6
name: _AI345944_1_m
constant: false
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AI345944
has only substance units: false

metaR PALFATPtc
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Hexadecanoate by the enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_94a8b9de_bdb3_424f_bbcf_1460d6df6ba1
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:51079
type: Species
constant: false
name: NDUFA13
initial amount: NaN
is: Q9P0J0

metaR SBCOAACOTx
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of suberyl coa for release into cytosol
type: Reaction

metaM 3hbcoa m
initial concentration: 1.0
is: HMDB01166
is: SBO:0000247
constant: false
is: CHEBI:57316
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
name: (S)-3-hydroxybutanoyl-CoA(4-)

metaR r0573
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:438652 NOTES:
is: SBO:0000176
name: Cholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
fast: false
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
product: MODEL1310110026#
is described by: ECO:0000000
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_3ba46c83_2445_4666_84c5_d406d951f7ae
is: P31040
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:6389
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
name: SDHA

metaR r1964
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
reversible: false
product: MODEL1310110026#
type: Reaction
reactant: MODEL1310110026#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110026#_d19417b9_c7d5_4891_b7cf_15a3de25a0e6
is encoded by: hsa:10870
type: Species
initial amount: NaN
has part: Q9UBK5
boundary condition: true
initial concentration: NaN
has part: P48736
name: HCST:PIK3CG
has only substance units: false
constant: false
is: SBO:0000297
is encoded by: hsa:5294

http://identifiers.org/biomodels.db/MODEL1310110026#_22eeda17_0c5e_46ca_b83f_6ae5266aeaf8
constant: false
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:AL038231
is: SBO:0000252
boundary condition: true
name: _AL038231_1_c

metaM cl c
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: Cl CHARGE: -1
is: C00115
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
name: Chloride
is: CHEBI:3966
type: Species
is: HMDB00492

http://identifiers.org/biomodels.db/MODEL1310110026#_139f020f_af7f_434a_bc81_6953b091d51a
is encoded by: hsa:9551
type: Species
name: ATP5J2
is: SBO:0000252
is: P56134
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110026#_cd14de2a_31bb_433c_9a09_e4e273274af8
initial amount: NaN
is: P08397
constant: false
name: HMBS
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:3145

http://identifiers.org/biomodels.db/MODEL1310110026#_be4c3446_7bb3_42ac_a572_655f36968746
name: MPI
has only substance units: false
boundary condition: true
type: Species
is: P34949
initial amount: NaN
is encoded by: hsa:4351
constant: false
is: SBO:0000252
initial concentration: NaN

metaM prist x
is: HMDB00795
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
initial amount: NaN
name: pristanic acid
is: CHEBI:51340
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_9523a0cd_b61b_43f8_b6f3_4ed7b8b79df6
has only substance units: false
name: SLC4A8
is: E7EML0
boundary condition: true
type: Species
is encoded by: hsa:9498
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaM pristcoa x
initial concentration: 1.0
type: Species
is: CHEBI:51341
has only substance units: false
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
name: pristanoyl coa

metaR r0570
is: SBO:0000176
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
reactant: MODEL1310110026#
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/6.3.3.2
product: MODEL1310110026#
kinetic law: MODEL1310110026#
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
fast: false
is described by: ECO:0000000
reversible: true
type: Reaction

metaR C12DCTD
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Dodecanedioic acid by diffusion
type: Reaction

metaR RTOTAL2FATPc
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal2 by enterocytes
type: Reaction

metaR r1670
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Y+LAT2 Utilized transport
modifier: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110026#

metaM m7mpdol U r
is: CHEBI:37636
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
name: (alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial concentration: 1.0
notes: FORMULA: C1665H2740N20O570P20 CHARGE: -20
type: Species
is: SBO:0000247

metaR DOPAt4 2 r
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reactant: MODEL1310110026#
is described by: ECO:0000269
name: Dopamine reversible transport in via sodium symport (1:2)
reversible: true
fast: false
modifier: MODEL1310110026#
is: SBO:0000185
product: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#

metaM digalsgalside hs c
is: http://identifiers.org/pubchem.compound/8384
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: Digalactosylceramidesulfate
type: Species
is: C06127
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C30H55NO15SFULLRCO CHARGE: -1 EHMN_ABBREVIATION: C06127

metaM Lcystin c
type: Species
is: SBO:0000247
name: L-cystine
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
constant: false
initial concentration: 1.0
is: CHEBI:16283
has only substance units: false
is: HMDB00192
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110026#_8c8366e4_e11f_449c_9a59_985601ad686f
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is: Q16718
name: NDUFA5
is encoded by: hsa:4698
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_72787249_c826_419f_aa59_57cfca256c64
is encoded by: hsa:2687
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
constant: false
boundary condition: true
name: GGT5
is: P36269

metaR r0426
product: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
modifier: MODEL1310110026#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.34
reactant: MODEL1310110026#
reversible: true
kinetic law: MODEL1310110026#
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3

metaR S6T10g
reversible: false
type: Reaction
product: MODEL1310110026#
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is described by: ECO:0000000
reactant: MODEL1310110026#
is: SBO:0000176
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110026#_abb1c2cf_dc8a_4015_83e1_89507ab65cc9
is encoded by: hsa:4694
type: Species
is: Q6IBB5
constant: false
name: NDUFA1
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_1e1032d5_9025_4473_9bd1_08480c929c85
name: _PRO1933_1_m
is encoded by: hsa:PRO1933
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
constant: false

metaM ddece1crn c
type: Species
is: HMDB03712
initial amount: NaN
has only substance units: false
notes: FORMULA: C19H35NO4 CHARGE: 0
name: dodecenoyl carnitine
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaM n2m2nmasn e
initial concentration: 1.0
is: C04946
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
initial amount: NaN
notes: FORMULA: C58H96N5O40X CHARGE: 0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_8631bb86_e1a1_4f3f_93b4_646c380e540d
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:622
name: BDH1
initial amount: NaN
has only substance units: false
is: Q02338

metaM xoldiolone c
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
is: CHEBI:28477
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
initial amount: NaN
is: HMDB02197
has only substance units: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110026#_c5dd500f_faa4_476f_9bb5_76dfd29f9912
constant: false
is encoded by: hsa:4124
is: SBO:0000252
name: MAN2A1
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: Q16706
boundary condition: true
type: Species

metaR GLUtr
reactant: MODEL1310110026#
reversible: true
type: Reaction
product: MODEL1310110026#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, needed to transport glu-L out of ER in conversion of leuktrC4-> leuktrD4 NJ
name: intracellular transport
fast: false
kinetic law: MODEL1310110026#

metaR MI1345PP
reversible: false
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110026#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.56
is version of: http://identifiers.org/ec-code/3.1.3.86
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.36
product: MODEL1310110026#
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_859c53ed_f1a6_4264_9953_d79d9ec486eb
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AGPAT7
name: _AGPAT7_1_c
type: Species
is: SBO:0000252
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_4d94e743_820b_4c20_9818_2fa18ba4c9b6
boundary condition: true
initial amount: NaN
name: HSD11B1
type: Species
is encoded by: hsa:3290
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false

metaR r0178
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.5.1.21
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
reversible: true
modifier: MODEL1310110026#
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110026#
product: MODEL1310110026#
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
reactant: MODEL1310110026#

metaR BILIRUBtr
type: Reaction
name: lipid, flip-flop intracellular transport
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reversible: true
kinetic law: MODEL1310110026#
product: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_32816089_edce_4e11_9c56_62c6b8652452
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
name: VNN3
is encoded by: hsa:55350
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_9a9bc30e_7555_4701_b807_1c96827e13a8
is: SBO:0000252
name: SDHA
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:6389
is: P31040
boundary condition: true

metaR SUCCTD
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

metaR H4ET3er
product: MODEL1310110026#
type: Reaction
reversible: false
kinetic law: MODEL1310110026#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.8.1
is described by: ECO:0000000
reactant: MODEL1310110026#
name: H4 phosphoethanolaminyl transferase, endoplasmic reticulum
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (84720.2) and (5281.1) or (84720.1) and (5281.2) or (5281.1) and (84720.1) or (84720.2) and (5281.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10781593,PMID:8463218 NOTES:NCD
fast: false

metaM gbside hs g
name: globoside
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
initial concentration: 1.0
initial amount: NaN
is: CHEBI:18259
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_fa294c03_5fd0_4e7b_a6ec_e0adc34f9f11
initial concentration: NaN
is: O75038
initial amount: NaN
constant: false
has only substance units: false
name: PLCH2
is: SBO:0000252
boundary condition: true
is encoded by: hsa:9651
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_8b2a531d_dca5_4e9b_8690_5167140babde
name: SLC16A10
initial concentration: NaN
is encoded by: hsa:117247
boundary condition: true
constant: false
is: SBO:0000252
is: Q8TF71
has only substance units: false
type: Species
initial amount: NaN

metaR GLYtm
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
fast: false
name: glycine passive transport to mitochondria
type: Reaction
product: MODEL1310110026#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110026#_e91664c1_17cc_49eb_b169_d20943b93101
constant: false
has only substance units: false
is: SBO:0000252
name: CHAT
initial concentration: NaN
is: D3DX95
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:1103

metaR r0179
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.27
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16
product: MODEL1310110026#
fast: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110026#

metaR GGH 7DHFl
name: Gamma-glutamyl hydrolase (7DHF), lysosomal
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.4.19.9
kinetic law: MODEL1310110026#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110026#
reactant: MODEL1310110026#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110026#_a1b0ca5b_5f00_4a44_948f_de6ad7126678
constant: false
is: Q9NRM0
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:56606
type: Species
name: SLC2A9

metaM idp e
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:58280
initial amount: NaN
boundary condition: false
is: HMDB03335
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
name: IDP(3-)

metaR S6T9g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
fast: false
type: Reaction
reactant: MODEL1310110026#
modifier: MODEL1310110026#
product: MODEL1310110026#
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110026#
is described by: ECO:0000000
reversible: false

metaR HEX4
name: hexokinase (D-mannose:ATP)
is described by: ECO:0000304
fast: false
type: Reaction
product: MODEL1310110026#
is: SBO:0000176
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.7.1.2
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (3098.2) or (2645.2) or (3098.3) or (2645.3) or (3098.4) or (3099.1) or (3098.5) or (3098.1) or (3101.1) or (80201.1) or (2645.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.7 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. also active in ecoli PMID: 4557975
is version of: http://identifiers.org/ec-code/2.7.1.1
reversible: false
modifier: MODEL1310110026#

metaR r2371
is: SBO:0000185
product: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110026#
reversible: true
type: Reaction
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110026#

metaR EX xolest2 hs LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cholesterol ester (from FULLR2) exchange
type: Reaction

metaM gua c
is: CHEBI:16235
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: C00242
type: Species
name: Guanine
has only substance units: false
is: HMDB00132

metaR PROt4 2 r
product: MODEL1310110026#
is described by: ECO:0000006
is: SBO:0000185
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
modifier: MODEL1310110026#
reactant: MODEL1310110026#
name: Proline transport (sodium symport) (2:1)
reversible: true
kinetic law: MODEL1310110026#
type: Reaction
fast: false

metaR PRASCS
type: Reaction
name: phosphoribosylaminoimidazolesuccinocarboxamide synthase
is described by: ECO:0000269
product: MODEL1310110026#
is: SBO:0000176
kinetic law: MODEL1310110026#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/6.3.2.6
reactant: MODEL1310110026#

metaR F1PGT
modifier: MODEL1310110026#
product: MODEL1310110026#
type: Reaction
is: SBO:0000176
reversible: true
fast: false
name: fucose-1-phosphate guanylyltransferase
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (8790.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.30 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.7.30

http://identifiers.org/biomodels.db/MODEL1310110026#_4bd7682a_0d00_4da6_87ea_23293bf5a042
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:2984
is: SBO:0000252
name: GUCY2C
is: P25092
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_56153d04_d6b0_4681_b27f_d6af25e5bf2d
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:6548
is: SBO:0000252
constant: false
is: P19634
initial concentration: NaN
name: SLC9A1

http://identifiers.org/biomodels.db/MODEL1310110026#_e8680347_225a_4fc5_8b95_f70ad6124cda
type: Species
is: SBO:0000252
name: FDPS
constant: false
is encoded by: hsa:2224
initial amount: NaN
has only substance units: false
boundary condition: true
is: P14324
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_bfe08a57_1b61_4046_aa7f_4f75929c02aa
is: SBO:0000297
is encoded by: hsa:4830
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
name: NME1:NME2
has only substance units: false
type: Species

metaR PCm
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/6.4.1.1
reversible: false
kinetic law: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: (5091.1) or (5091.2) SUBSYSTEM: Pyruvate metabolism EC Number: 6.4.1.1 Confidence Level: 4 AUTHORS: PMID:6548474 NOTES:TV Metabolism at a glance
name: pyruvate carboxylase
is described by: ECO:0000269
modifier: MODEL1310110026#
is: SBO:0000176
type: Reaction
product: MODEL1310110026#

metaM hdcea r
has only substance units: false
boundary condition: false
type: Species
is: HMDB03229
constant: false
is: CHEBI:32372
name: palmitoleate
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C16H29O2 CHARGE: -1 INCHI: InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7- HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850

metaR OMHPALTD
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of w-hydroxypalmitic acid by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_7f0f4d15_a514_4e47_b948_48bb2c0133c9
constant: false
is encoded by: hsa:5295
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: PIK3R1
boundary condition: true
is: E7EX19
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_e44e1e77_58b3_4217_96a0_6f0e69ee4d36
is encoded by: hsa:410
initial concentration: NaN
constant: false
name: ARSA
is: P15289
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR RE1573M
is version of: http://identifiers.org/ec-code/5.3.3.8
product: MODEL1310110026#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
fast: false
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
name: RE1573
reversible: true

metaR HEX1
notes: GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.7.1.1
type: Reaction
name: hexokinase (D-glucose:ATP)
reversible: false
kinetic law: MODEL1310110026#
product: MODEL1310110026#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.2
is described by: ECO:0000134
fast: false
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_6c235c71_55f4_40ec_b244_2b341cbe04ed
is: B3KWF4
is encoded by: hsa:63917
initial amount: NaN
name: GALNT11
constant: false
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252

metaM idp c
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
name: IDP(3-)
is: CHEBI:58280
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB03335

metaM 5adtststerones e
name: 5alpha-Dihydrotestosterone sulfate
constant: false
boundary condition: false
is: HMDB06278
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
type: Species
has only substance units: false

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

metaM pail45p hs n
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
name: phosphatidylinositol 4,5-bisphosphate
is: SBO:0000247
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
is: CHEBI:28910

metaR COQ5m
type: Reaction
fast: false
kinetic law: MODEL1310110026#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10777520,PMID:1965190,PMID:7380842 NOTES:_2.1.1.- IT
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110026#
name: Ubiquinone biosynthesis methyltransferase COQ5
product: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_a624e0f3_372e_42ea_8bed_5f9815df9b2f
is encoded by: hsa:55753
initial concentration: NaN
type: Species
is: Q9ULD0
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: OGDHL
constant: false

metaR DCMPDA
type: Reaction
product: MODEL1310110026#
reversible: true
is version of: http://identifiers.org/ec-code/3.5.4.12
is: SBO:0000176
kinetic law: MODEL1310110026#
is described by: ECO:0000254
modifier: MODEL1310110026#
name: dCMP deaminase
fast: false
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD

metaR r1116
is: SBO:0000185
kinetic law: MODEL1310110026#
fast: false
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:
type: Reaction
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
reactant: MODEL1310110026#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110026#_cd0fde4f_ac7c_4f89_a966_3a726cfda61f
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
name: PIGQ
is encoded by: hsa:9091
type: Species
has only substance units: false
is: B2RAU6
is: SBO:0000252

metaM gua e
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
name: guanine
is: SBO:0000247
initial concentration: 1.0
is: HMDB00132
is: CHEBI:16235
boundary condition: false
has only substance units: false

metaM 2hb e
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
is: HMDB00008
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
name: 2-Hydroxybutyrate
initial concentration: 1.0
boundary condition: false
is: CHEBI:1148

metaR GLYtp
product: MODEL1310110026#
kinetic law: MODEL1310110026#
type: Reaction
reactant: MODEL1310110026#
fast: false
reversible: true
is described by: ECO:0000000
is: SBO:0000185
name: glycine passive transport to peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:TDV

http://identifiers.org/biomodels.db/MODEL1310110026#_b0856795_9d93_4e9b_86f9_c2fb3a04825c
name: PPA2
is encoded by: hsa:27068
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: F8WDN9
initial amount: NaN
constant: false
type: Species
boundary condition: true

metaR EHGLATm
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.1 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
modifier: MODEL1310110026#
reversible: false
is described by: ECO:0000212
fast: false
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase, mitochondrial
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.6.1.1
is: SBO:0000176
product: MODEL1310110026#
type: Reaction

metaR r2374
is: SBO:0000185
kinetic law: MODEL1310110026#
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110026#
product: MODEL1310110026#

metaM urate e
type: Species
constant: false
initial concentration: 1.0
is: C00366
boundary condition: false
initial amount: NaN
is: HMDB00289
is: SBO:0000247
name: Urate
is: CHEBI:17775
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_e41fdfc3_238a_4a66_8e6e_fb7ef266211b
type: Species
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:AI191472
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: _AI191472_1_c

metaR r0130
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
fast: false
type: Reaction
reactant: MODEL1310110026#
is: SBO:0000176
product: MODEL1310110026#
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110026#_725e86c2_0809_4631_8fff_ee55aead72f1
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
name: PDE9A
type: Species
constant: false
is encoded by: hsa:5152

metaR C80CPT1
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of octanoylcarnitine
type: Reaction

metaR EX CLPND LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: clupanodonic acid (docosapentaenoic (n-3)) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_dd1f0c0c_b4e8_4480_b15d_2005dadbbbfa
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AI539321
name: _AI539321_1_c

http://identifiers.org/biomodels.db/MODEL1310110026#_8768b186_6a1e_40a7_ad3d_76cae44a284a
initial amount: NaN
is encoded by: hsa:10786
boundary condition: true
name: SLC17A3
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
is: O00476
constant: false

metaM pppg9 m
type: Species
is: HMDB01097
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C34H38N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00656 EHMN_ABBREVIATION: C01079
constant: false
is: C01079
initial concentration: 1.0
name: Protoporphyrinogen IX
is: CHEBI:57307
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_39f26c24_a994_493a_967b_d975603a4e09
initial amount: NaN
name: ADCY3
is encoded by: hsa:109
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
is: B3KT86
constant: false

metaR RE1533M
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
modifier: MODEL1310110026#
reversible: true
fast: false
product: MODEL1310110026#
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE1533
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:

metaR r2375
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110026#
is: SBO:0000185
product: MODEL1310110026#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110026#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110026#_9a9f33e5_78fe_48d6_a8a7_79019032c064
boundary condition: true
type: Species
constant: false
is encoded by: hsa:481
has only substance units: false
has part: A3KLL5
has part: B7Z2T0
initial amount: NaN
is encoded by: hsa:478
initial concentration: NaN
name: ATP1A3:ATP1B1
is: SBO:0000297

metaM 5adtststerones c
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB06278
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
has only substance units: false
initial amount: NaN
name: 5alpha-Dihydrotestosterone sulfate
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110026#_7351057e_9d31_4a38_a6fe_b393333170c3
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:79369
name: B3GNT4
is: Q9C0J1

metaR PTE4x
is version of: http://identifiers.org/ec-code/3.1.2.2
name: peroxisomal acyl-CoA thioesterase
is: SBO:0000176
is described by: ECO:0000269
fast: false
reversible: false
reactant: MODEL1310110026#
product: MODEL1310110026#
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (10965.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10944470 NOTES:NJ
type: Reaction

metaR r0578
kinetic law: MODEL1310110026#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
reversible: true
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/4.1.2.27
reactant: MODEL1310110026#
modifier: MODEL1310110026#
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
is: SBO:0000176

metaM fe2 c
has only substance units: false
boundary condition: false
initial amount: NaN
name: Fe2+
is: CHEBI:29033
is: C00023
constant: false
is: HMDB00692
is: SBO:0000247
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
initial concentration: 1.0
type: Species

metaM 2hb c
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
is: CHEBI:1148
is: SBO:0000247
boundary condition: false
is: HMDB00008
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: 2-Hydroxybutyrate
constant: false

metaM met L e
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:16643
boundary condition: false
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
initial concentration: 1.0
is: HMDB00696
name: L-methionine
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_e8b1ad88_caed_4c2c_9b40_f7fb5bf5a804
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: COX7A2L
is: Q6FGA0
boundary condition: true
type: Species
is encoded by: hsa:9167
constant: false

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_67611f66_cd76_449c_9055_1c03e76e2ee9
has only substance units: false
is encoded by: hsa:4705
boundary condition: true
type: Species
is: O95299
initial concentration: NaN
name: NDUFA10
constant: false
initial amount: NaN
is: SBO:0000252

metaR Q10H2e
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.
kinetic law: MODEL1310110026#
reversible: true
name: transport of ubiquinol into lymph
is described by: ECO:0000134
product: MODEL1310110026#
reactant: MODEL1310110026#

metaR r2372
kinetic law: MODEL1310110026#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
product: MODEL1310110026#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110026#

metaM urate c
is: C00366
has only substance units: false
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
initial concentration: 1.0
is: HMDB00289
is: SBO:0000247
is: CHEBI:17775
initial amount: NaN
name: Urate
type: Species
boundary condition: false
constant: false

metaR HIVCRNe
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-isovaleryl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_950d5ac0_27c8_49dc_9af5_574a555fd712
is encoded by: hsa:1962
constant: false
initial amount: NaN
is: Q9NY65
type: Species
boundary condition: true
is: SBO:0000252
name: EHHADH
has only substance units: false
initial concentration: NaN

metaR LTA4H
reactant: MODEL1310110026#
fast: false
name: Leukotriene A-4 hydrolase
kinetic law: MODEL1310110026#
is described by: ECO:0000134
type: Reaction
reversible: false
product: MODEL1310110026#
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.3.2.6
is: SBO:0000176
notes: GENE_ASSOCIATION: (4048.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 3.3.2.6 Confidence Level: 4 AUTHORS: PMID:7918238 NOTES:NJ

metaR HEX7
kinetic law: MODEL1310110026#
reversible: false
product: MODEL1310110026#
type: Reaction
is described by: ECO:0000304
is: SBO:0000176
name: hexokinase (D-fructose:ATP)
is version of: http://identifiers.org/ec-code/2.7.1.1
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.7.1.2
fast: false
notes: GENE_ASSOCIATION: (2645.2) or (2645.3) or (3098.3) or (3098.1) or (3101.1) or (3098.2) or (3099.1) or (2645.1) or (3098.4) or (80201.1) or (3098.5) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. Same as 2.7.1.4
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_50ca4d71_f800_4eab_a198_7aead32546b6
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AI990637
constant: false
initial concentration: NaN
name: _AI990637_1_x
type: Species
initial amount: NaN

metaR C81CRNe
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of octenoyl carnitine into the extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_e2b26384_ddb8_48c0_8539_997bc91a1e92
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:83884
is: Q9BXI2
is: SBO:0000252
constant: false
initial concentration: NaN
name: SLC25A2

metaR M4MPDOL Uter
reactant: MODEL1310110026#
name: m4mpdol flippase
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
product: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110026#_63c2290a_00d5_4536_b1eb_dd6b258a271a
has only substance units: false
constant: false
is: Q6AI14
is encoded by: hsa:389015
initial concentration: NaN
name: SLC9A4
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true

metaM fpram c
is: HMDB06211
is: C04640
initial concentration: 1.0
type: Species
is: CHEBI:58478
constant: false
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C8H15N3O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01329 EHMN_ABBREVIATION: C04640

metaM ser L m
is: CHEBI:17115
is: HMDB00187
name: L-serine
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaM ksii core2 pre5 g
is: SBO:0000247
is: CHEBI:58053
notes: FORMULA: C61H99N5O43X CHARGE: -1
constant: false
initial amount: NaN
is: HMDB00175
initial concentration: 1.0
is: C00130
has only substance units: false
boundary condition: false
type: Species
name: keratan sulfate II biosynthesis, precursor 5

metaR r2373
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
reactant: MODEL1310110026#
reversible: true
product: MODEL1310110026#
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110026#_9a636ad8_b5f1_41fa_9dd7_dc08ff4101fd
has only substance units: false
is encoded by: hsa:4731
constant: false
name: NDUFV3
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN

metaM CE5120 m
constant: false
boundary condition: false
is: SBO:0000247
name: trans-2-cis-8-tetradecadienoyl-CoA
initial amount: NaN
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,14-15,22-24,28-30,34,45-46H,4-7,10-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5120
initial concentration: 1.0
type: Species
is: CHEBI:57923
has only substance units: false

metaR DURIPP
is described by: ECO:0000269
fast: false
reactant: MODEL1310110026#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.1
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
is version of: http://identifiers.org/ec-code/2.4.2.3
name: deoxyuridine phosphorylase
reversible: true
modifier: MODEL1310110026#
product: MODEL1310110026#

metaR r0579
reactant: MODEL1310110026#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
is version of: http://identifiers.org/ec-code/1.13.11.19
product: MODEL1310110026#
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000176

metaM thcrm hs g
is: CHEBI:24636
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C36H66NO17FULLRCO CHARGE: 0
has only substance units: false
constant: false
name: trihexosyl ceramide

http://identifiers.org/biomodels.db/MODEL1310110026#_3f349ab3_3990_490a_b256_8efb8013bc3a
initial concentration: NaN
is: SBO:0000252
name: MYO5B
has only substance units: false
initial amount: NaN
is encoded by: hsa:4645
type: Species
constant: false
is: Q9H6Y6
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110026#_00314416_7c69_45e9_b213_549d02003e27
constant: false
name: ATP1B1
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is: A3KLL5
is: SBO:0000252
is encoded by: hsa:481
has only substance units: false

metaR FUMSO4tm
reactant: MODEL1310110026#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is: SBO:0000185
modifier: MODEL1310110026#
reversible: true
type: Reaction
name: Fumarate:sulfate antiport, mitochondrial
product: MODEL1310110026#
kinetic law: MODEL1310110026#

metaM HC02175 c
initial concentration: 1.0
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
boundary condition: false
constant: false
name: caprate
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:27689

metaR MANtg
is: SBO:0000185
is described by: ECO:0000000
name: mannose efflux from Golgi apparatus
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
reactant: MODEL1310110026#
type: Reaction
reversible: false
product: MODEL1310110026#
kinetic law: MODEL1310110026#

metaM paf hs e
has only substance units: false
boundary condition: false
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
initial concentration: 1.0
type: Species
is: CHEBI:36707
initial amount: NaN
constant: false
is: SBO:0000247

metaM maltpt e
has only substance units: false
name: maltopentaose
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
is: http://identifiers.org/pubchem.compound/5141
initial amount: NaN
is: C02052
type: Species
is: HMDB01296

http://identifiers.org/biomodels.db/MODEL1310110026#_f706aff1_0a26_4b42_8c65_fad3fc85a967
type: Species
constant: false
initial concentration: NaN
is: Q9BZQ4
name: NMNAT2
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:23057

metaR SPODMn
name: superoxide dismutase, nuclear
kinetic law: MODEL1310110026#
product: MODEL1310110026#
modifier: MODEL1310110026#
reactant: MODEL1310110026#
fast: false
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.15.1.1
reversible: false
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
is: SBO:0000176

metaM creat e
is: CHEBI:16919
type: Species
initial concentration: 1.0
constant: false
name: creatine
is: SBO:0000247
is: HMDB00064
boundary condition: false
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
has only substance units: false
initial amount: NaN

metaM uacgam g
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:57705
is: HMDB00290
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
name: UDP-N-acetyl-alpha-D-glucosamine(2-)

http://identifiers.org/biomodels.db/MODEL1310110026#_0395aae8_546a_423e_885a_4eb51242f617
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:23396
is: O60331
name: PIP5K1C
type: Species

metaR r1667
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: true
name: Y+LAT2 Utilized transport
type: Reaction
is: SBO:0000185
product: MODEL1310110026#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110026#
fast: false

metaR EX nac LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinate exchange
type: Reaction

metaM xol7ah c
is: CHEBI:2290
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-19,21-25,29H,6-16H2,1-5H3/t18-,19+,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01460 EHMN_ABBREVIATION: C05451
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB06892
initial amount: NaN
name: 7alpha-hydroxy-5beta-cholestan-3-one
constant: false
initial concentration: 1.0
boundary condition: false

metaR r1668
is: SBO:0000185
fast: false
reactant: MODEL1310110026#
type: Reaction
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110026#
product: MODEL1310110026#
modifier: MODEL1310110026#
is described by: ECO:0000000
reversible: true

metaR r0716
kinetic law: MODEL1310110026#
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reactant: MODEL1310110026#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110026#
fast: false
reversible: false
type: Reaction

metaM creat c
is: HMDB00064
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
is: CHEBI:16919
has only substance units: false
initial amount: NaN
name: creatine
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300

metaR r0122
product: MODEL1310110026#
type: Reaction
reactant: MODEL1310110026#
name: GTP:pyruvate O2-phosphotransferase Purine metabolism EC:2.7.1.40
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110026#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110026#_31c4c2ca_2245_4407_a8e0_973959e11481
has only substance units: false
name: _AA502753_1_m
is encoded by: hsa:AA502753
type: Species
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_3a9299f4_2e9e_41a2_9263_7b4f917c1b27
initial concentration: NaN
is: P15291
has only substance units: false
name: B4GALT1
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:2683
type: Species
constant: false

metaR EX uri LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Uridine
type: Reaction

metaR 34DHPHEt
is: SBO:0000185
reversible: true
product: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:NCD
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
name: 3,4-Dihydroxy-L-phenylalanine transport
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_e84712f4_fed3_4c67_825b_6a5bd3d2d0b6
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:10246
is: O00624
boundary condition: true
initial concentration: NaN
name: SLC17A2

http://identifiers.org/biomodels.db/MODEL1310110026#_7baef4e3_61ce_46ca_8f07_c1ce6c3e4888
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
name: PCBD1
type: Species
is encoded by: hsa:5092
is: P61457

http://identifiers.org/biomodels.db/MODEL1310110026#_5bdbae30_2351_4f2c_b3a7_3914e24ecfd7
initial amount: NaN
constant: false
has only substance units: false
name: IDH2
is: SBO:0000252
type: Species
is: P48735
is encoded by: hsa:3418
initial concentration: NaN
boundary condition: true

metaR r1669
name: Y+LAT2 Utilized transport
is: SBO:0000185
reactant: MODEL1310110026#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110026#
reversible: true
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110026#
type: Reaction

metaR RE3004M
product: MODEL1310110026#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110026#
fast: false
modifier: MODEL1310110026#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE3004

metaM paf hs c
is: SBO:0000247
boundary condition: false
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
initial concentration: 1.0
type: Species
is: CHEBI:36707
has only substance units: false
initial amount: NaN
constant: false

metaM HC02175 e
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
boundary condition: false
name: caprate
type: Species
is: CHEBI:27689
has only substance units: false

metaM galacglcgalgluside hs g
constant: false
type: Species
name: Lc4Cer
boundary condition: false
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
is: CHEBI:17103
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaR PGCD
notes: GENE_ASSOCIATION: (26227.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.1.95 Confidence Level: 4 AUTHORS: PMID:10713460 NOTES:
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110026#
name: phosphoglycerate dehydrogenase
reversible: false
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.1.1.95
type: Reaction
reactant: MODEL1310110026#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110026#_3ccf8770_cf94_48a6_993c_0dec3ceefb7f
initial concentration: NaN
name: DEGS1
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8560
boundary condition: true

metaR HSD3A1r
is: SBO:0000176
type: Reaction
product: MODEL1310110026#
reversible: true
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
is version of: http://identifiers.org/ec-code/1.1.1.225
is described by: ECO:0000269
reactant: MODEL1310110026#
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
fast: false

metaR r1814
kinetic law: MODEL1310110026#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110026#
name: Y+LAT2 Utilized transport
product: MODEL1310110026#
is described by: ECO:0000000
modifier: MODEL1310110026#

metaM zymstnl r
is: CHEBI:16608
boundary condition: false
is: SBO:0000247
is: HMDB06841
type: Species
initial amount: NaN
has only substance units: false
constant: false
name: 5alpha-cholest-8-en-3beta-ol
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
initial concentration: 1.0

metaR r0718
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110026#
product: MODEL1310110026#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.181
type: Reaction
reversible: false
modifier: MODEL1310110026#
name: (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reactant: MODEL1310110026#

metaR PYDXNK
is described by: ECO:0000269
modifier: MODEL1310110026#
name: pyridoxine kinase
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.7.1.35
fast: false
type: Reaction
reversible: false
kinetic law: MODEL1310110026#
is: SBO:0000176
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (8566.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaM CE0713 m
is: CHEBI:30623
constant: false
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
is: SBO:0000247
initial amount: NaN
name: 3-oxolinoleoyl-CoA
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB02329
type: Species

metaM gacpail hs r
type: Species
has only substance units: false
is: CHEBI:61548
name: glucosaminyl-acylphosphatidylinositol
boundary condition: false
constant: false
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN
is: C00092
is: SBO:0000247
initial concentration: 1.0
is: HMDB01401

metaR DUTPDPn
notes: GENE_ASSOCIATION: (1854.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.23 Confidence Level: 4 AUTHORS: PMID:12799180,PMID:8631816,PMID:9070952 NOTES:
kinetic law: MODEL1310110026#
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110026#
name: dUTP diphosphatase, nuclear
is version of: http://identifiers.org/ec-code/3.6.1.23
reversible: false
type: Reaction
reactant: MODEL1310110026#
modifier: MODEL1310110026#
fast: false

metaR CMPSASn
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.43
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
fast: false
reactant: MODEL1310110026#
name: CMP sialic acid synthase, nuclear
type: Reaction
product: MODEL1310110026#
is described by: ECO:0000304
reversible: false

metaR FE2tm
kinetic law: MODEL1310110026#
is described by: ECO:0000000
reactant: MODEL1310110026#
is: SBO:0000185
name: iron (II) transport
fast: false
reversible: false
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10383398,PMID:12755454 NOTES:TDV Lange H, 1999.
type: Reaction

metaR O2ter
kinetic law: MODEL1310110026#
is described by: ECO:0000000
fast: false
product: MODEL1310110026#
type: Reaction
name: O2 transport, endoplasmic reticulum
reactant: MODEL1310110026#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaR PHCHGSm
product: MODEL1310110026#
reactant: MODEL1310110026#
reversible: true
type: Reaction
kinetic law: MODEL1310110026#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:taken from KEGG map. No enzyme assigned, so assumed this is a non-enzymatic reaction. NCD
is described by: ECO:0000000
name: L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial

metaM uacgam c
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
type: Species
constant: false
has only substance units: false
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
boundary condition: false
initial amount: NaN
is: CHEBI:57705
initial concentration: 1.0
is: HMDB00290
is: SBO:0000247

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

metaR r0127
name: L-Asparagine amidohydrolase Alanine and aspartate metabolism / Cyanoamino acid metabolism / Nitrogen metabolism EC:3.5.1.1 EC:3.5.1.38
reactant: MODEL1310110026#
type: Reaction
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110026#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110026#
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.5.4.16
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.38 Confidence Level: 0 AUTHORS: PMID:4311065,PMID:4894450 NOTES:

metaR PI5P4K
type: Reaction
kinetic law: MODEL1310110026#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.67
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (5297.1) or (55361.1) or (5298.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.149 Confidence Level: 4 AUTHORS: PMID:10358929,PMID:9211928,PMID:9367159 NOTES:NCD
is: SBO:0000176
product: MODEL1310110026#
name: phosphatidylinositol-5-phosphate 4-kinase
fast: false
modifier: MODEL1310110026#

metaR PCt
reversible: true
modifier: MODEL1310110026#
product: MODEL1310110026#
is: SBO:0000185
notes: GENE_ASSOCIATION: (5244.1) or (5244.3) or (5244.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11826283,PMID:7912658 NOTES:for PC secretion into bile NJ
kinetic law: MODEL1310110026#
is described by: ECO:0000269
reactant: MODEL1310110026#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.3.44
name: phosphatidylcholine transporter
fast: false

http://identifiers.org/biomodels.db/MODEL1310110026#_2d53c1e7_55a7_49d5_a0ee_343fca96e5f6
constant: false
is: SBO:0000297
has only substance units: false
is encoded by: hsa:9517
is encoded by: hsa:10558
has part: O15270
name: SPTLC1:SPTLC2
boundary condition: true
initial concentration: NaN
has part: O15269
type: Species
initial amount: NaN

metaR RE3079X
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:11356164 NOTES:IT - fixed proton
reversible: true
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
name: RE3079
product: MODEL1310110026#

metaR TIGCRNe
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of tiglyl carnitine into the extra cellular fluid
type: Reaction

metaR L LACt2r
product: MODEL1310110026#
modifier: MODEL1310110026#
type: Reaction
reversible: true
name: L-lactate reversible transport via proton symport
is: SBO:0000185
fast: false
is described by: ECO:0000269
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
kinetic law: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_d5ced345_101e_4f47_a752_09f0cb47bbef
constant: false
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:197257
boundary condition: true
name: LDHD

http://identifiers.org/biomodels.db/MODEL1310110026#_8837aaea_2c2f_4e4d_806f_cd7a0c9692d3
has part: Q96I99
type: Species
boundary condition: true
name: SUCLG2:SUCLG1
initial amount: NaN
is encoded by: hsa:8801
is encoded by: hsa:8802
is: SBO:0000297
initial concentration: NaN
has part: P53597
has only substance units: false
constant: false

metaR EX aicar LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
type: Reaction

metaR OCDCAtr
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110026#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_94abff52_7db9_49b8_9f0a_658729a3acff
has part: P08195
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000297
is encoded by: hsa:6520
has part: Q9NS82
initial amount: NaN
name: SLC7A10:SLC3A2
constant: false
initial concentration: NaN
is encoded by: hsa:56301

metaM acnacngalgbside hs g
is: SBO:0000247
initial amount: NaN
is: CHEBI:3338
constant: false
has only substance units: false
is: C00036
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
type: Species
is: HMDB00223
name: disialyl galactosylgloboside

metaM prostgi2 c
constant: false
name: prostaglandin I2(1-)
initial amount: NaN
is: HMDB01335
boundary condition: false
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
is: CHEBI:57403
initial concentration: 1.0
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110026#_2f24b124_7bf0_4c92_82f3_0aca38faf153
is: SBO:0000252
constant: false
is encoded by: hsa:51703
boundary condition: true
type: Species
is: Q9ULC5
name: ACSL5
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaM asp L m
initial concentration: 1.0
constant: false
is: HMDB00191
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:29991
name: L-aspartate(1-)
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
is: SBO:0000247

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

metaM fe2 m
is: C00023
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:29033
is: HMDB00692
boundary condition: false
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
type: Species
is: SBO:0000247
initial concentration: 1.0
name: Fe2+

http://identifiers.org/biomodels.db/MODEL1310110026#_3268901b_33bf_47e8_8ad3_f066f56cbc7e
is encoded by: hsa:1962
boundary condition: true
name: EHHADH
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
is: Q9NY65
type: Species

metaR S6TASE9ly
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
modifier: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110026#
reversible: true
product: MODEL1310110026#
name: N-acetylgalactosamine-6-sulfatase, lysosomal
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

metaR ASCBt4
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
kinetic law: MODEL1310110026#
is described by: ECO:0000269
is: SBO:0000185
fast: false
type: Reaction
name: L-ascorbate transport via proton symport
reversible: true
modifier: MODEL1310110026#
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_69fd2b93_19ae_40f8_b27b_cdc0245c7163
initial concentration: NaN
is encoded by: hsa:6487
boundary condition: true
initial amount: NaN
type: Species
constant: false
name: ST3GAL3
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110026#_ebb809c5_709a_4c73_a483_994943701542
is encoded by: hsa:4830
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
name: NME1
boundary condition: true
initial amount: NaN

metaM ppbng c
name: Porphobilinogen
is: SBO:0000247
constant: false
is: HMDB00245
is: CHEBI:58126
boundary condition: false
initial concentration: 1.0
type: Species
is: C00931
notes: FORMULA: C10H13N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00588 EHMN_ABBREVIATION: C00931
initial amount: NaN
has only substance units: false

metaM HC02020 r
type: Species
boundary condition: false
name: Cholesterol-ester-palm
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C43H76O2 CHARGE: 0 INCHI: InChI=1S/C43H76O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-23-41(44)45-36-28-30-42(5)35(32-36)24-25-37-39-27-26-38(34(4)22-20-21-33(2)3)43(39,6)31-29-40(37)42/h24,33-34,36-40H,7-23,25-32H2,1-6H3/t34-,36+,37+,38-,39+,40+,42+,43-/m1/s1
is: CHEBI:3663
constant: false

metaM ksii core2 deg6 l
initial amount: NaN
name: keratan sulfate II (core 2-linked), degradation product 6
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C44H72N4O33SX CHARGE: -1
is: HMDB00143
is: CHEBI:12936
has only substance units: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110026#_eb5d01d6_413c_402d_a957_8b641e43ca2b
is: B3KQ63
type: Species
is encoded by: hsa:3242
initial concentration: NaN
initial amount: NaN
name: HPD
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110026#_521b5a92_2bfe_4e30_9a8d_4c0e758452bc
name: SCD
initial concentration: NaN
is: O00767
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:6319
boundary condition: true
initial amount: NaN
type: Species

metaR TCYNTt
kinetic law: MODEL1310110026#
reversible: false
product: MODEL1310110026#
name: Thiocyanate transport via diffusion (cytosol to extracellular)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110026#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110026#_c27cb6ba_42a1_4bcf_80cb_28b09b1842f8
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:6579
is: P46721
initial amount: NaN
name: SLCO1A2
boundary condition: true
constant: false

metaM acnacngalgbside hs e
is: HMDB00223
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:3338
constant: false
boundary condition: false
is: C00036
initial concentration: 1.0
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
name: disialyl galactosylgloboside
type: Species

metaR SFGTH
product: MODEL1310110026#
kinetic law: MODEL1310110026#
is: SBO:0000176
reversible: true
fast: false
type: Reaction
modifier: MODEL1310110026#
name: S-Formylglutathione hydralase
notes: GENE_ASSOCIATION: (2098.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.1.2.12 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.2.12
is described by: ECO:0000269
reactant: MODEL1310110026#

metaM prostgi2 e
name: prostaglandin I2(1-)
is: CHEBI:57403
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
boundary condition: false
is: HMDB01335
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
initial concentration: 1.0

metaR r0860
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1459,PMID:14598172,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000185
fast: false
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/4.1.2.27
kinetic law: MODEL1310110026#
name: Utilized transport
modifier: MODEL1310110026#

metaR r0129
modifier: MODEL1310110026#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.40
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
reactant: MODEL1310110026#
type: Reaction
product: MODEL1310110026#
kinetic law: MODEL1310110026#
is: SBO:0000176

metaR PIter
product: MODEL1310110026#
is described by: ECO:0000212
reactant: MODEL1310110026#
is: SBO:0000185
kinetic law: MODEL1310110026#
fast: false
modifier: MODEL1310110026#
name: phosphate transport, endoplasmic reticulum
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD

metaM decdicoa c
is: HMDB01168
constant: false
is: SBO:0000247
boundary condition: false
name: decadienoylcoa
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0

metaR DGK1
kinetic law: MODEL1310110026#
is described by: ECO:0000269
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.7.4.8
fast: false
name: deoxyguanylate kinase (dGMP:ATP)
reactant: MODEL1310110026#
is: SBO:0000176
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110026#

metaM xylu L c
type: Species
is: HMDB00751
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
constant: false
name: L-xylulose
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:17399
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110026#_ec535c56_b328_4b13_86b7_ff1028d81002
initial concentration: NaN
is encoded by: hsa:2678
constant: false
name: GGT1
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_a7679a98_128c_4514_b8ce_253f6e788c03
type: Species
is: O15254
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:8310
name: ACOX3
boundary condition: true
is: SBO:0000252
constant: false

metaR MALSO4tm
fast: false
reactant: MODEL1310110026#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
name: Malate:sulfate antiport, mitochondrial
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
product: MODEL1310110026#
reversible: true
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110026#_b75d1bb0_9450_4ab9_aca7_8ce649527e15
has only substance units: false
is: SBO:0000252
boundary condition: true
is: F5GWS5
is encoded by: hsa:55811
type: Species
name: ADCY10
initial amount: NaN
constant: false
initial concentration: NaN

metaM ura e
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
is: CHEBI:17568
boundary condition: false
is: HMDB00300
type: Species
initial amount: NaN
name: uracil

metaM c101crn c
name: decenoyl carnitine
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C17H31NO4 CHARGE: 0
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB13205

metaM tetdece1crn e
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB02014
initial concentration: 1.0
name: tetradecenoyl carnitine
notes: FORMULA: C21H39NO4 CHARGE: 0
initial amount: NaN

metaM acnacngalgbside hs c
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:3338
has only substance units: false
constant: false
is: HMDB00223
is: C00036
name: disialyl galactosylgloboside

metaR SIAASE2ly
reactant: MODEL1310110026#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
name: sialidase, lysosomal
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110026#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110026#
type: Reaction

metaM HC00591 c
initial amount: NaN
initial concentration: 1.0
name: 2-oxoglutaramate
has only substance units: false
constant: false
type: Species
boundary condition: false
is: CHEBI:16769
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110026#_ab7aa5da_fb70_4c7d_92e7_d312981a2bc8
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is: O43674
initial amount: NaN
is: SBO:0000252
name: NDUFB5
is encoded by: hsa:4711
boundary condition: true

metaR NACHEXA14ly
kinetic law: MODEL1310110026#
is described by: ECO:0000000
product: MODEL1310110026#
fast: false
name: beta-N-acetylhexosaminidase A, lysosomal
reactant: MODEL1310110026#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
modifier: MODEL1310110026#
reversible: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD

metaR VALTAm
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
name: valine transaminase, mitochondiral
is version of: http://identifiers.org/ec-code/2.6.1.42
kinetic law: MODEL1310110026#
reversible: true
product: MODEL1310110026#
fast: false
modifier: MODEL1310110026#
reactant: MODEL1310110026#

metaM Lcystin e
is: CHEBI:16283
boundary condition: false
type: Species
initial amount: NaN
name: L-cystine
is: HMDB00192
initial concentration: 1.0
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
is: SBO:0000247
constant: false
has only substance units: false

metaR r0580
product: MODEL1310110026#
is described by: ECO:0000000
reactant: MODEL1310110026#
modifier: MODEL1310110026#
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110026#
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
reversible: true
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
is version of: http://identifiers.org/ec-code/1.3.99.7

metaM fucgalacglcgalgluside hs g
type: Species
initial concentration: 1.0
is: HMDB01263
is: CHEBI:17917
is: SBO:0000247
notes: FORMULA: C50H89N2O26FULLRCO CHARGE: 0
has only substance units: false
name: Type IH glycolipid
boundary condition: false
initial amount: NaN
constant: false

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

metaM od2coa c
is: C16218
is: HMDB06529
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: CE2244
initial amount: NaN
type: Species
constant: false
is: CHEBI:50570
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: trans-Octadec-2-enoyl-CoA
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110026#_11082434_a086_404f_95e8_54781d3c12f1
is: SBO:0000252
name: _NM_013421_1_m
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:NM 013421

metaR r1660
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110026#
is: SBO:0000185
reactant: MODEL1310110026#
type: Reaction
product: MODEL1310110026#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110026#_d8c721c9_17be_49a9_9a06_a8c7fb2c9c26
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
name: OCRL
is encoded by: hsa:4952
type: Species

metaM CE4794 m
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
name: cis-6-dodecenoyl-CoA
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,20-22,26-28,32,43-44H,4-7,10-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE4794
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:57923

http://identifiers.org/biomodels.db/MODEL1310110026#_5693a969_2703_4c86_a48f_f388307aac1b
has only substance units: false
name: TAT
is encoded by: hsa:6898
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: P17735
constant: false
is: SBO:0000252

metaM c81coa c
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
initial concentration: 1.0
is: C05276
is: HMDB03949
name: octenoylcoa
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false

metaR SPODMx
is version of: http://identifiers.org/ec-code/1.15.1.1
fast: false
reversible: false
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
type: Reaction
is: SBO:0000176
name: superoxide dismutase, peroxisome
modifier: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000269
kinetic law: MODEL1310110026#
product: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_4d26972f_3196_475c_8868_907d65b5d404
type: Species
is encoded by: hsa:1103
name: CHAT
initial concentration: NaN
is: Q6LEN6
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN

metaM ura c
constant: false
is: C00106
initial concentration: 1.0
name: Uracil
type: Species
is: HMDB00300
has only substance units: false
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:17568

metaM tetdece1crn c
type: Species
is: HMDB02014
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: tetradecenoyl carnitine
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C21H39NO4 CHARGE: 0

metaR VALtec
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
reactant: MODEL1310110026#
fast: false
product: MODEL1310110026#
reversible: true
modifier: MODEL1310110026#
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
name: L-valine transport via diffusion (extracellular to cytosol)

metaM but e
is: HMDB00039
type: Species
is: CHEBI:17968
constant: false
boundary condition: false
is: SBO:0000247
name: butyrate
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaM c101crn e
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C17H31NO4 CHARGE: 0
name: decenoyl carnitine
is: SBO:0000247
is: HMDB13205
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_6462b16e_4852_4c0a_9802_f9b1d95cd76e
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000297
type: Species
is encoded by: hsa:9551
initial amount: NaN
is encoded by: hsa:517
initial concentration: NaN
has part: F8W7V3
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2

http://identifiers.org/biomodels.db/MODEL1310110026#_metaR_EX_s2l2fn2m2masn_LPAREN_e_RPAREN_
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: PA6 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_c68cac01_65e7_4e68_ad30_925428f5bb7e
name: PI4KA
is: SBO:0000252
constant: false
is: B4DYG5
boundary condition: true
is encoded by: hsa:5297
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN

metaR r1661
modifier: MODEL1310110026#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110026#
is described by: ECO:0000000
reactant: MODEL1310110026#
product: MODEL1310110026#

metaR r1966
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000000
reversible: false
is: SBO:0000185
fast: false
kinetic law: MODEL1310110026#
type: Reaction
modifier: MODEL1310110026#
name: Y+LAT2 Utilized transport

metaM 3ohdcoa m
initial amount: NaN
type: Species
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
name: 3-oxopalmitoyl-CoA(4-)
is: CHEBI:57349
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB06402
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110026#_2a7b3581_b832_4651_9c82_d4aa6171ae07
name: TST
is encoded by: hsa:7263
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q16762
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_8b3a36d3_7d61_44c8_9965_a714b95277d3
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:79053
is: A6NDW6
name: ALG8
boundary condition: true
is: SBO:0000252
type: Species

metaR GGH 5DHFl
reversible: false
reactant: MODEL1310110026#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.4.19.9
modifier: MODEL1310110026#
is: SBO:0000176
name: Gamma-glutamyl hydrolase (5DHF), lysosomal
kinetic law: MODEL1310110026#
is described by: ECO:0000000
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT

metaM HC02214 e
type: Species
has only substance units: false
is: CHEBI:28852
name: prostaglandin-f1alpha
constant: false
initial amount: NaN
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110026#_fa1305a2_f482_4d5b_90c4_9d64961e1507
is: Q08828
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: ADCY1
boundary condition: true
is encoded by: hsa:107

http://identifiers.org/biomodels.db/MODEL1310110026#_fd7a1418_8762_46ee_af5b_2057d8c6e9b4
initial concentration: NaN
constant: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
type: Species
has part: Q6IB54
is: SBO:0000297
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:522

metaM gdpfuc c
name: GDP-L-fucose(2-)
has only substance units: false
is: CHEBI:57984
initial concentration: 1.0
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
type: Species
is: HMDB01095
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaR r1662
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110026#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110026#
reversible: true

metaM HC01401 m
initial concentration: 1.0
is: CHEBI:27668
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
name: (S)-3-Hydroxydodecanoyl-CoA
boundary condition: false
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
has only substance units: false

metaR SIAASEly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.1.6.4
name: sialidase, lysosomal
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110026#
reactant: MODEL1310110026#
reversible: false
fast: false

metaR ACGAMK
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110026#
fast: false
modifier: MODEL1310110026#
reversible: false
reactant: MODEL1310110026#
name: N-acetylglucosamine kinase
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.59 Confidence Level: 4 AUTHORS: PMID:10824116 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.59
is described by: ECO:0000269

metaM CE0849 m
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
name: cis,cis-palmito-7,10-dienoyl-CoA
constant: false
is: CHEBI:57795
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110026#_330fa8d8_be40_448f_ba3b_60bc1131c618
name: PLCG1
is: SBO:0000252
is: P19174
initial amount: NaN
is encoded by: hsa:5335
constant: false
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true

metaM xoldiolone r
initial concentration: 1.0
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
is: HMDB02197
has only substance units: false
constant: false
is: CHEBI:28477
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110026#_ffa7754a_6e52_4270_a572_ad81ee59b1f7
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: P78381
constant: false
is: SBO:0000252
type: Species
name: SLC35A2
boundary condition: true
is encoded by: hsa:7355

metaR DMNONCRNCPT2
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110026#
fast: false
reactant: MODEL1310110026#
type: Reaction
name: DMNONCRNCPT2
reversible: true
product: MODEL1310110026#
is described by: ECO:0000000

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_4a557d96_ece9_4131_84e8_01b9656c3624
boundary condition: true
name: MTMR6
has only substance units: false
is: SBO:0000252
is: Q9Y217
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:9107

metaR AG13T12g
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
modifier: MODEL1310110026#
is described by: ECO:0000000

metaM but c
is: CHEBI:17968
initial amount: NaN
type: Species
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
has only substance units: false
is: SBO:0000247
name: butyrate
is: HMDB00039
initial concentration: 1.0
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_2f340ec8_95d3_4dbd_a5dd_ff9f46048957
type: Species
boundary condition: true
is encoded by: hsa:7371
has only substance units: false
is: SBO:0000252
constant: false
name: UCK2
is: Q9BZX2
initial amount: NaN
initial concentration: NaN

metaM xmp c
has only substance units: false
type: Species
constant: false
is: CHEBI:57464
notes: FORMULA: C10H11N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00478 EHMN_ABBREVIATION: C00655
boundary condition: false
is: SBO:0000247
name: Xanthosine 5'-phosphate
is: C00655
is: HMDB01554
initial amount: NaN
initial concentration: 1.0

metaM HC02214 c
name: prostaglandin-f1alpha
boundary condition: false
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:28852
type: Species

metaR SRTNt6 2 r
reactant: MODEL1310110026#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6532.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
product: MODEL1310110026#
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
is: SBO:0000185
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)

metaR ALADGLNexR
is described by: ECO:0000304
product: MODEL1310110026#
reversible: true
fast: false
modifier: MODEL1310110026#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
name: L-alanine/glutamine reversible exchange

http://identifiers.org/biomodels.db/MODEL1310110026#_dc4ec1c5_776d_4c56_8448_9bfa8790e24f
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:T83654
constant: false
type: Species
has only substance units: false
name: _T83654_1_c

metaR PIACGT
notes: GENE_ASSOCIATION: (5279.1) and (51227.2) and (5283.1) and (5277.2) and (9091.1) and (8818.1) or (5279.1) and (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) or (51227.1) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.2) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (5279.2) and (8818.1) or (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.1) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.2) or (51227.1) and (5277.1) and (5283.1) and (9091.1) and (5279.2) and (8818.1) or (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (9091.2) and (5277.3) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (8818.2) and (5279.2) or (5279.1) and (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.2) or (51227.1) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.2) and (9091.2) and (5277.1) and (5283.1) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.2) and (5283.1) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (5283.1) and (5277.2) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (5283.1) and (5277.2) and (9091.1) and (8818.2) or (51227.3) and (9091.2) and (5283.1) and (5277.2) and (5279.2) and (8818.1) or (5279.1) and (51227.3) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (51227.1) and (9091.2) and (5277…
fast: false
type: Reaction
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.4.1.83
product: MODEL1310110026#
is described by: ECO:0000000
modifier: MODEL1310110026#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.4.1.198
name: phosphatidylinositol N-acetylglucosaminyltransferase

http://identifiers.org/biomodels.db/MODEL1310110026#_b98d9e00_70e6_4b7a_ac41_f62c4756b804
is encoded by: hsa:8694
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
constant: false
initial amount: NaN
name: DGAT1
is: O75907

http://identifiers.org/biomodels.db/MODEL1310110026#_256eb523_fa73_4297_b64f_db0433d3171c
is encoded by: hsa:8310
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000297
initial concentration: NaN
boundary condition: true
name: EHHADH:ACAA1:HSD17B4:ACOX3
has part: O15254
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_ef8b6830_e45d_40d2_be5b_59d7167d392e
constant: false
initial amount: NaN
name: ENTPD8
boundary condition: true
is: Q5MY95
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:377841

metaM hdcea c
boundary condition: false
initial concentration: 1.0
is: CHEBI:32372
is: SBO:0000247
type: Species
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
name: Hexadecenoate (n-C16:1)
initial amount: NaN
is: HMDB03229
has only substance units: false
constant: false

metaR r1664
is: SBO:0000185
product: MODEL1310110026#
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
type: Reaction
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#

metaR r0013
product: MODEL1310110026#
reversible: false
fast: false
modifier: MODEL1310110026#
reactant: MODEL1310110026#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110026#
name: beta-N-acetylhexosaminidase Aminosugars metabolism EC:3.2.1.52
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.2.1.52 Confidence Level: 0 AUTHORS: PMID:10481922,PMID:2423070,PMID:6219664,PMID:758959 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR FALDH
fast: false
kinetic law: MODEL1310110026#
is described by: ECO:0000269
name: formaldehyde dehydrogenase
is version of: http://identifiers.org/ec-code/1.1.1.1
modifier: MODEL1310110026#
is: SBO:0000176
reactant: MODEL1310110026#
reversible: true
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
product: MODEL1310110026#
type: Reaction

metaR KHte
kinetic law: MODEL1310110026#
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
reactant: MODEL1310110026#
is described by: ECO:0000134
fast: false
reversible: true
type: Reaction
name: KHte

http://identifiers.org/biomodels.db/MODEL1310110026#_d7f7e73f_d2f7_4e38_b9d0_26a3584b5a8b
type: Species
constant: false
initial amount: NaN
has only substance units: false
name: SLC36A1
is: SBO:0000252
is encoded by: hsa:206358
is: Q1LZ56
boundary condition: true
initial concentration: NaN

metaR IPDPtx
fast: false
is: SBO:0000185
is described by: ECO:0000134
product: MODEL1310110026#
name: Isopentenyl diphosphate transport (peroxisome)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 5.3.3.2 Confidence Level: 1 AUTHORS: PMID:11111079 NOTES:
type: Reaction
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: true

metaR r1665
reactant: MODEL1310110026#
modifier: MODEL1310110026#
reversible: true
is: SBO:0000185
product: MODEL1310110026#
kinetic law: MODEL1310110026#
type: Reaction
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110026#_d4094d3f_6373_4ad8_aa9c_34db964b2913
constant: false
type: Species
initial amount: NaN
boundary condition: true
name: NADSYN1
is encoded by: hsa:55191
initial concentration: NaN
is: Q6IA69
has only substance units: false
is: SBO:0000252

metaR TREHe
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000269
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR
reversible: false
type: Reaction
name: alpha,alpha-trehalase
is version of: http://identifiers.org/ec-code/3.2.1.28
kinetic law: MODEL1310110026#
is: SBO:0000176
fast: false

metaM retinol 9 cis c
is: CHEBI:17336
has only substance units: false
name: 9-cis-retinol
initial concentration: 1.0
boundary condition: false
is: HMDB06217
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
type: Species

metaR NDPK6n
product: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is: SBO:0000176
is described by: ECO:0000304
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
reversible: true
fast: false
type: Reaction

metaR ARACHDt2
name: fatty acid transport via diffusion
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110026#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110026#

metaR FUT12g
is: SBO:0000176
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.4.1.69
fast: false
name: Galactoside 2-alpha-L-fucosyltransferase 1
reactant: MODEL1310110026#
product: MODEL1310110026#
reversible: false
modifier: MODEL1310110026#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110026#_cbc930c6_a389_45d9_90bc_41d8e2b5cb32
type: Species
is encoded by: hsa:N63787
initial amount: NaN
name: _N63787_1_c
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR CYTK1n
kinetic law: MODEL1310110026#
fast: false
is: SBO:0000176
name: cytidylate kinase (CMP),nuclear
is described by: ECO:0000269
modifier: MODEL1310110026#
type: Reaction
product: MODEL1310110026#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR r1666
product: MODEL1310110026#
kinetic law: MODEL1310110026#
type: Reaction
modifier: MODEL1310110026#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
reactant: MODEL1310110026#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110026#_861b066a_2bd3_47ec_a9d3_685c66069feb
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:51727
has only substance units: false
is: B2R6S5
name: CMPK1
constant: false
type: Species
initial concentration: NaN

metaR DTDPtn
name: dTDP nuclear transport
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110026#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110026#_753a59cb_9106_4de7_84cc_23f4b465abda
type: Species
has only substance units: false
is: SBO:0000252
is: P00325
is encoded by: hsa:125
boundary condition: true
constant: false
name: ADH1B
initial concentration: NaN
initial amount: NaN

metaR UPPDC1
fast: false
type: Reaction
kinetic law: MODEL1310110026#
is described by: ECO:0000269
product: MODEL1310110026#
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.37
modifier: MODEL1310110026#
reactant: MODEL1310110026#
name: uroporphyrinogen decarboxylase (uroporphyrinogen III)
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Heme synthesis EC Number: 4.1.1.37 Confidence Level: 4 AUTHORS: PMID:3015909 NOTES:Acts on a number of porphyrinogens, r0606
is: SBO:0000176

metaR r0714
reactant: MODEL1310110026#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
kinetic law: MODEL1310110026#
reversible: false
type: Reaction
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
product: MODEL1310110026#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110026#_f548bf53_d89e_42cd_990b_25015844d0a7
is encoded by: hsa:84649
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: Q96PD7
constant: false
is: SBO:0000252
boundary condition: true
name: DGAT2
type: Species

metaR DOLPMT3 Uer
reversible: false
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110026#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.260
modifier: MODEL1310110026#
is described by: ECO:0000000
product: MODEL1310110026#
is: SBO:0000176
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)

metaM 3pg c
initial amount: NaN
name: 3-Phospho-D-glycerate
is: C00197
type: Species
has only substance units: false
is: CHEBI:58272
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00807
is: http://identifiers.org/pubchem.compound/3497

metaR RE3520E
type: Reaction
is version of: http://identifiers.org/ec-code/1.11.1.9
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
name: RE3520
fast: false
is: SBO:0000176
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
modifier: MODEL1310110026#
reversible: true
is described by: ECO:0000000

metaR PTDCACRNCPT2
modifier: MODEL1310110026#
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ
is: SBO:0000176
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
name: pentadecanoate transport into the mitochondria
type: Reaction
is described by: ECO:0000000
reversible: false

metaR r2364
reversible: true
product: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110026#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110026#

metaM cholcoar x
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
is: HMDB02178
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:58677
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_49910d25_b646_4f7e_947a_a2b7814a8447
initial concentration: NaN
is: Q8TF08
has only substance units: false
name: COX7B2
boundary condition: true
constant: false
type: Species
is encoded by: hsa:170712
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110026#_2695fa77_058a_45ac_a169_4cf0d9538de4
is: Q6NVY1
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: HIBCH
boundary condition: true
is encoded by: hsa:26275
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_3ec4abbd_41ca_45fc_af24_e0cdc0f11ae5
type: Species
initial concentration: NaN
initial amount: NaN
name: LDHA
is: SBO:0000252
is: P00338
has only substance units: false
constant: false
is encoded by: hsa:3939
boundary condition: true

metaR S2TASE3ly
reactant: MODEL1310110026#
reversible: false
product: MODEL1310110026#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3423.2) or (3423.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
fast: false
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.1.6.13
name: iduronate-2-sulfatase, lysosomal
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110026#

metaM ksii core2 deg9 l
is: HMDB00143
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C30H50N3O20X CHARGE: 0
boundary condition: false
has only substance units: false
constant: false
name: keratan sulfate II (core 2-linked), degradation product 9
is: CHEBI:12936
type: Species
initial concentration: 1.0

metaR r0160
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
product: MODEL1310110026#
is described by: ECO:0000000
fast: false
name: L-Serine:pyruvate aminotransferase Glycine, serine and threonine metabolism EC:2.6.1.51
modifier: MODEL1310110026#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.3.2
reversible: false
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.51 Confidence Level: 0 AUTHORS: PMID:10347152,PMID:6469715 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110026#_502d52d4_e689_49cb_9d1f_e89a8ce687cc
is: P51178
initial concentration: NaN
is encoded by: hsa:5333
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
constant: false
name: PLCD1
initial amount: NaN

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

metaR FACOAL1831
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110026#
product: MODEL1310110026#
name: fatty-acid--CoA ligase
modifier: MODEL1310110026#
is described by: ECO:0000269
reactant: MODEL1310110026#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ

metaR FUT33g
reactant: MODEL1310110026#
type: Reaction
name: fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group included) 1
fast: false
notes: GENE_ASSOCIATION: (2525.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.65 Confidence Level: 4 AUTHORS: PMID:12424536,PMID:12493760,PMID:1977660 NOTES:NJ
kinetic law: MODEL1310110026#
product: MODEL1310110026#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.65
modifier: MODEL1310110026#
reversible: false

metaR r2365
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110026#
type: Reaction
product: MODEL1310110026#
is described by: ECO:0000000
fast: false
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
reversible: true
kinetic law: MODEL1310110026#

metaR PTDCACRNCPT1
type: Reaction
reactant: MODEL1310110026#
name: carnitine fatty-acyl transferase
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (1375.1) or (1375.4) or (1375.3) or (1374.1) or (126129.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
modifier: MODEL1310110026#
reversible: false
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110026#

metaR RE1532M
is: SBO:0000176
is described by: ECO:0000000
name: RE1532
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
modifier: MODEL1310110026#
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
reversible: true
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
product: MODEL1310110026#

metaR r0587
kinetic law: MODEL1310110026#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
reactant: MODEL1310110026#
modifier: MODEL1310110026#
is described by: ECO:0000000
product: MODEL1310110026#

metaR r0434
is: SBO:0000176
kinetic law: MODEL1310110026#
product: MODEL1310110026#
type: Reaction
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
reactant: MODEL1310110026#
is described by: ECO:0000000
fast: false
reversible: true

metaR ALA DASH DTDe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: no specific transporter for exit of D-alanine could be found, so diffusion mechanism is assumed. NOTES:no specific transporter for exit of D-alanine could be found, so diffusion mechanism is assumed.
is: SBO:0000185
reactant: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
fast: false
is described by: ECO:0000134
product: MODEL1310110026#
reversible: false
name: exit of D-alanine from the enterocytes

http://identifiers.org/biomodels.db/MODEL1310110026#_14af92f2_3e02_48e5_be78_dac762b842b5
is encoded by: hsa:2194
is: P49327
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
type: Species
has only substance units: false
name: FASN
initial amount: NaN

metaR FAOXC150m
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:by extension from even chain lumped FAO - should double-check stoich in future NJ
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110026#
modifier: MODEL1310110026#
fast: false
kinetic law: MODEL1310110026#
reversible: false
type: Reaction
name: Beta oxidation of long chain fatty acid (odd chain)
is described by: ECO:0000269
product: MODEL1310110026#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110026#_0b342993_7b6a_4706_9515_19f321e39bf5
is: Q9NS82
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:56301
boundary condition: true
constant: false
type: Species
has only substance units: false
name: SLC7A10

http://identifiers.org/biomodels.db/MODEL1310110026#_9f199c8b_d86c_4caa_8cf5_8914cc8fa222
is: SBO:0000252
type: Species
name: PDE1B
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:5153
is: Q7Z364
initial concentration: NaN

metaM gpail hs c
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:17049
type: Species
notes: FORMULA: C15H28NO13PFULLRCO2FULLR2CO2 CHARGE: 0 EHMN_ABBREVIATION: C04248
boundary condition: false
name: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_67bbc8f0_6773_4a69_9959_e4c53aa42c9f
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
name: HGD
type: Species
is encoded by: hsa:3081
initial amount: NaN
is: SBO:0000252
is: Q93099

metaR NDPK8n
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear
product: MODEL1310110026#
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000304
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110026#_fcbe0419_41e3_4c91_ad6c_60d4719255a7
initial concentration: NaN
name: PIK3C2B
has only substance units: false
is: O00750
type: Species
initial amount: NaN
is encoded by: hsa:5287
constant: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110026#_0cb73943_b571_4014_a6e3_095a70f9b51b
boundary condition: true
name: FUT8
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
is: B4DFS7
is encoded by: hsa:2530
initial amount: NaN
constant: false

metaM 5aizc c
type: Species
constant: false
is: C04751
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C9H11N3O9P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01347 EHMN_ABBREVIATION: C04751
is: CHEBI:58564
is: HMDB06273
initial amount: NaN
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate

metaR IDOAASE4ly
kinetic law: MODEL1310110026#
fast: false
reactant: MODEL1310110026#
reversible: false
product: MODEL1310110026#
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.2.1.76
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
is: SBO:0000176
type: Reaction
name: alpha-L-iduronidase, lysosomal
is described by: ECO:0000000

metaR r2366
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110026#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#

metaR C6DCc
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of adipoylcarnitine
type: Reaction

metaR C101CRNe
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of decenoyl carnitine into extra cellular space
type: Reaction

metaR FACOAL1832
fast: false
modifier: MODEL1310110026#
is: SBO:0000176
kinetic law: MODEL1310110026#
product: MODEL1310110026#
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ, RE3114C
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_a57fbfbb_f6a7_4833_9005_a03f8a724375
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: PDE1A
is: P54750
initial concentration: NaN
type: Species
is encoded by: hsa:5136
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_98838c78_5e07_4d04_bb27_d8e66327952c
is encoded by: hsa:81537
is: Q9BX95
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
name: SGPP1
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_cdf34da5_c8a4_42d2_aa45_acd4bf27c114
initial concentration: NaN
has only substance units: false
name: SLC4A5
is: SBO:0000252
boundary condition: true
is encoded by: hsa:57835
type: Species
initial amount: NaN
constant: false

metaR APOCF
is: SBO:0000176
kinetic law: MODEL1310110026#
name: Apocarboxylase formation
reversible: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110026#
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10191093 NOTES:IT faked reaction to balance reaction in human biotin metabolism
fast: false

http://identifiers.org/biomodels.db/MODEL1310110026#_d69515b1_1d6a_4874_8b7c_4477471aafb2
initial amount: NaN
constant: false
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
name: COX6C
is encoded by: hsa:1345
initial concentration: NaN
is: P09669

metaR r2367
kinetic law: MODEL1310110026#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110026#
reversible: true
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110026#

metaM ptth m
is: HMDB03426
boundary condition: false
name: pantetheine
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:16753
initial concentration: 1.0
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_d56bf9c3_1d1f_4c50_a35e_fbca7dffe80b
constant: false
type: Species
initial concentration: NaN
is: B7Z2T0
initial amount: NaN
is encoded by: hsa:478
is: SBO:0000252
name: ATP1A3
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110026#_d563d2e1_2762_4fac_94a2_784b025fdd49
name: PHYH
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5264
is: O14832
initial amount: NaN

metaM nmn c
name: NMN
is: C00455
initial amount: NaN
is: CHEBI:14649
is: SBO:0000247
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
has only substance units: false
is: HMDB00229
initial concentration: 1.0
constant: false
boundary condition: false
type: Species

metaR r2368
is: SBO:0000185
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110026#
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110026#
type: Reaction
fast: false
reversible: true
is described by: ECO:0000000

metaR r0437
reversible: true
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
reactant: MODEL1310110026#
modifier: MODEL1310110026#
is described by: ECO:0000000
kinetic law: MODEL1310110026#
product: MODEL1310110026#
fast: false
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.2.13

http://identifiers.org/biomodels.db/MODEL1310110026#_17a08a26_4fef_4bfb_a961_98a311d114e4
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:221823
initial concentration: NaN
name: PRPS1L1
constant: false
is: P21108
is: SBO:0000252
initial amount: NaN

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

metaR NADHtpu
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110026#
is described by: ECO:0000000
name: NADH transporter, peroxisome
reversible: false
fast: false
reactant: MODEL1310110026#
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ

http://identifiers.org/biomodels.db/MODEL1310110026#_3ef6ecb8_e1de_4202_a63f_fd988cbc966b
name: _AA081045_1_e
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:AA081045
constant: false
is: SBO:0000252
type: Species

metaM CE5121 m
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
initial concentration: 1.0
constant: false
is: CHEBI:57449
name: trans-3-decenoyl-CoA
is: SBO:0000247
type: Species

metaR RE3346M
is: SBO:0000176
name: RE3346
notes: GENE_ASSOCIATION: (217.1) or (219.1) or (501.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
fast: false
modifier: MODEL1310110026#
is described by: ECO:0000000
reactant: MODEL1310110026#
reversible: true
product: MODEL1310110026#

metaR r1682
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: false
is: SBO:0000185
reactant: MODEL1310110026#
name: Y+LAT2 Utilized transport
fast: false
modifier: MODEL1310110026#
product: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_d299abd4_3174_4081_a8f2_ebcf95d04bc8
type: Species
is encoded by: hsa:10678
initial concentration: NaN
is: SBO:0000252
name: B3GNT2
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true

metaR DOLASNT Uer
reactant: MODEL1310110026#
name: Dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase (uterus)
notes: GENE_ASSOCIATION: (6185.1 and 1650.1 and 6184.1 and 1603.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.119 Confidence Level: 0 AUTHORS: PMID:8413235,PMID:9367678 NOTES:NCD
type: Reaction
is: SBO:0000176
product: MODEL1310110026#
fast: false
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.119

metaR r2369
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110026#_d36da100_3c71_46ed_a1ed_1817e5075df5
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
name: SLC35B2
is: SBO:0000252
type: Species
is: Q8TB61
is encoded by: hsa:347734

metaM n2m2nmn l
constant: false
is: SBO:0000247
is: HMDB00243
is: C00022
type: Species
is: CHEBI:15361
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C50H84N4O36 CHARGE: 0
has only substance units: false
name: reducing GlcNAc removed form of n2m2nmasn (w/o peptide)
is: http://identifiers.org/pubchem.compound/3324

metaM pser L c
initial concentration: 1.0
constant: false
is: HMDB01721
notes: FORMULA: C3H5NO6P CHARGE: -3 INCHI: InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00621
name: O-Phospho-L-serine
has only substance units: false
is: SBO:0000247
is: CHEBI:15811
boundary condition: false
type: Species
initial amount: NaN

metaR r1090
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: false
reactant: MODEL1310110026#
name: TCDB:2.A.47.1.9 TCDB:2.A.29.7.2
product: MODEL1310110026#
is: SBO:0000185
kinetic law: MODEL1310110026#
type: Reaction

metaR SO4HCOtex
product: MODEL1310110026#
is described by: ECO:0000304
kinetic law: MODEL1310110026#
reversible: false
fast: false
name: sulfate transport via bicarbonate countertransport
is: SBO:0000185
notes: GENE_ASSOCIATION: (115111.1) or (115019.2) or (1836.1) or (115111.2) or (116369.2) or (284129.1) or (10861.2) or (116369.1) or (10861.1) or (10861.3) or (115019.1) or (1811.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
type: Reaction
modifier: MODEL1310110026#
reactant: MODEL1310110026#

metaR GLCURter
fast: false
name: glucuronate endoplasmic reticular transport
is: SBO:0000185
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110026#
type: Reaction
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_eaa09b84_5761_41c3_9d3c_5ec569675cb0
is: Q01959
name: SLC6A3
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:6531

metaR MDHm
name: malate dehydrogenase, mitochondrial
type: Reaction
reactant: MODEL1310110026#
product: MODEL1310110026#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.37
kinetic law: MODEL1310110026#
reversible: true
is described by: ECO:0000134
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical

http://identifiers.org/biomodels.db/MODEL1310110026#_8059138c_523b_456c_a7fd_26038556bbed
is encoded by: hsa:6582
is: SBO:0000252
type: Species
initial amount: NaN
is: O15244
name: SLC22A2
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_7b8d4097_18eb_4e19_98a2_33a3cf93efd8
name: PRPS2
is encoded by: hsa:5634
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
type: Species
is: P11908
initial amount: NaN

metaM itacon m
has only substance units: false
is: CHEBI:17240
initial amount: NaN
is: HMDB02092
initial concentration: 1.0
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
name: itaconate(2-)
type: Species
is: SBO:0000247
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_e7bcbcfd_478d_44bc_8cb6_bc967aeb5cc3
type: Species
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is: Q9H0P0
is encoded by: hsa:51251
has only substance units: false
name: NT5C3
is: SBO:0000252

metaR TETPENT3t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: true
type: Reaction
name: fatty acid transport via diffusion
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110026#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110026#_6246c965_d12b_4a57_b775_89f6d6816e80
type: Species
has part: Q6IB04
is: SBO:0000297
is encoded by: hsa:84720
is encoded by: hsa:5281
name: PIGF:PIGO
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_c723589c_abd4_46bc_8176_382a1bcc0a05
initial amount: NaN
constant: false
name: GAL3ST1
is: Q99999
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:9514
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_3c1735a0_c1b1_40e4_9365_f34912074059
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: P17516
has only substance units: false
boundary condition: true
is encoded by: hsa:1109
name: AKR1C4
type: Species
constant: false

metaR r0584
is described by: ECO:0000000
reversible: true
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
type: Reaction
product: MODEL1310110026#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_bbcaab13_c365_4c84_9b51_1ba493563d0d
is: Q9UI40
name: SLC24A2
initial concentration: NaN
is encoded by: hsa:25769
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
boundary condition: true
has only substance units: false

metaR r1953
product: MODEL1310110026#
reactant: MODEL1310110026#
modifier: MODEL1310110026#
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110026#
reversible: false
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM ksi deg15 l
is: HMDB00143
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C160H257N11O140S8 CHARGE: -8
initial amount: NaN
boundary condition: false
has only substance units: false
name: keratan sulfate I, degradation product 15
is: CHEBI:12936
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_0f3c8fa7_2fd2_4d17_adbd_6134ec09d9d8
initial amount: NaN
name: CPT1B
initial concentration: NaN
type: Species
has only substance units: false
constant: false
boundary condition: true
is: E9PCP2
is encoded by: hsa:1375
is: SBO:0000252

metaM dhap e
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
boundary condition: false
is: HMDB01473
is: CHEBI:57642
constant: false
initial concentration: 1.0
name: glycerone phosphate(2-)
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species

metaR CLHCO3tex2
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
is described by: ECO:0000304
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
product: MODEL1310110026#
is: SBO:0000185
name: chloride transport via bicarbonate countertransport (2:1)
type: Reaction
fast: false
reversible: false
modifier: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_491a4797_22b3_43d9_a4c4_8e7b95f65d4f
has only substance units: false
is: SBO:0000252
name: KDSR
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is: Q06136
type: Species
is encoded by: hsa:2531

http://identifiers.org/biomodels.db/MODEL1310110026#_5206331b_21a0_4b0a_93bb_1676c52f929c
initial amount: NaN
name: _X63359_1_c
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:X63359
has only substance units: false
boundary condition: true

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

metaR UDPGALtg
name: UDP-Gal Golgi transport via CMP antiport
reactant: MODEL1310110026#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110026#
type: Reaction
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
fast: false
is described by: ECO:0000269
product: MODEL1310110026#
modifier: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_3f347ace_3f30_4d90_afca_b76c8b0929d3
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
type: Species
name: PYCRL
is encoded by: hsa:65263
is: Q53H96
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_076bfed5_fcc2_4cb9_a5e4_1cb41fca9e40
constant: false
name: ATP5F1
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: Q08ET0
is encoded by: hsa:515
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_5b97cce7_23a2_4727_9067_681172a607a2
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:5152
initial concentration: NaN
constant: false
name: PDE9A
has only substance units: false
type: Species

metaR BPNT
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
is: SBO:0000176
name: 3',5'-bisphosphate nucleotidase
product: MODEL1310110026#
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.1.3.7
type: Reaction
reactant: MODEL1310110026#
modifier: MODEL1310110026#
fast: false
is described by: ECO:0000269
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110026#_9085a9c6_d6e1_4616_8151_ffe5157bd6e5
name: PCBD1
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:5092
initial concentration: NaN
constant: false
boundary condition: true

metaR FAOXC18480m
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
reactant: MODEL1310110026#
modifier: MODEL1310110026#
reversible: false
product: MODEL1310110026#
type: Reaction
name: Beta oxidation of fatty acid
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 4 degrees loss of saturation -> only 1 fad oxidized to fadh2 peroxisomal (very long chain FA) c18:4,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.8.1

metaM man1p c
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:35374
initial concentration: 1.0
constant: false
name: D-Mannose 1-phosphate
has only substance units: false
is: HMDB06330
type: Species
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636

metaR EX paf hs LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-acteylglycerol 3-phosphocholine (homo sapiens) exchange
type: Reaction

metaM atp e
boundary condition: false
initial concentration: 1.0
is: CHEBI:57299
is: HMDB00538
type: Species
constant: false
initial amount: NaN
is: C00002
has only substance units: false
is: SBO:0000247
name: ATP(4-)

metaR LYStm
name: Lysine mitochondrial transport via ornithine carrier
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
reversible: true
modifier: MODEL1310110026#
fast: false
kinetic law: MODEL1310110026#
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110026#
reactant: MODEL1310110026#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_11bc01aa_b513_48d9_be48_dbba30dc4c05
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
name: ALG8
initial amount: NaN
has only substance units: false
is encoded by: hsa:79053

http://identifiers.org/biomodels.db/MODEL1310110026#_377b1be8_0ffb_4103_a5b4_3dc99704680d
name: PIP4K2C
boundary condition: true
is encoded by: hsa:79837
initial concentration: NaN
has only substance units: false
type: Species
is: B3KQV3
initial amount: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110026#_dfe45970_9885_427a_85f9_d9c4dc8dc2e4
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
name: VNN3
is encoded by: hsa:55350
constant: false
boundary condition: true

metaM xtsn c
name: xanthosine
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
is: HMDB00299
type: Species
is: CHEBI:18107
has only substance units: false
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
is: SBO:0000247

metaM HC00361 c
is: SBO:0000247
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:58335
initial amount: NaN
boundary condition: false
type: Species
name: sedoheptulose 1,7-bisphosphate(4-)

metaM dhap c
has only substance units: false
initial concentration: 1.0
is: CHEBI:57642
type: Species
initial amount: NaN
is: C00111
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB01473
name: Dihydroxyacetone phosphate
is: http://identifiers.org/pubchem.compound/3411

metaM imp c
name: IMP
is: CHEBI:58053
is: HMDB00175
is: SBO:0000247
is: C00130
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130

metaR S6T8g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110026#
product: MODEL1310110026#
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
is described by: ECO:0000000
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
fast: false
is: SBO:0000176

metaM icit c
has only substance units: false
is: CHEBI:16087
initial concentration: 1.0
boundary condition: false
is: HMDB00193
name: Isocitrate
is: C00311
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
constant: false
type: Species
is: SBO:0000247
initial amount: NaN

metaR ATPtm
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (291.1) or (293.1) or (292.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
product: MODEL1310110026#
fast: false
is: SBO:0000185
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
name: ADP/ATP transporter, mitochondrial
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110026#_2db17691_4c9d_44ce_a3d7_3466cb548b4f
has only substance units: false
name: SDHD
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:6392
is: O14521
boundary condition: true

metaR r0166
reactant: MODEL1310110026#
is described by: ECO:0000000
name: Uridine triphosphate pyrophosphohydrolase Pyrimidine metabolism EC:3.6.1.19
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110026#
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
product: MODEL1310110026#

metaM 3hpp m
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
has only substance units: false
constant: false
type: Species
is: CHEBI:16510
name: 3-hydroxypropionate
boundary condition: false
is: HMDB00700

http://identifiers.org/biomodels.db/MODEL1310110026#_c4a24353_d689_40dc_a12c_2fb6eaa7edf1
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
is: Q9Y2A9
initial amount: NaN
name: B3GNT3
has only substance units: false
is encoded by: hsa:10331

http://identifiers.org/biomodels.db/MODEL1310110026#_6aec01d2_f281_4db1_8bbe_fe9bf39d7cee
type: Species
boundary condition: true
initial concentration: NaN
name: ABCD1
is: P33897
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:215

metaR PDE4
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.1.4.35
type: Reaction
name: 3',5'-cyclic-nucleotide phosphodiesterase
fast: false
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.1.4.17
is described by: ECO:0000269
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (5139.1) or (5146.1) or (5152.17) or (50940.1) or (5152.6) or (5136.1) or (5152.11) or (5152.2) or (8654.2) or (10846.1) or (5152.10) or (5145.1 and 5158.1 and 5149.1) or (5140.1) or (5152.12) or (5152.15) or (5137.1) or (5136.2) or (5138.1) or (5152.5) or (5153.1) or (5152.20) or (5152.19) or (5152.16) or (8654.3) or (5152.14) or (5152.13) or (5152.7) or (5152.3) or (5140.2) or (8654.1) or (5152.18) or (5145.1 and 5146.1 and 5158.1 and 5147.1 and 5148.1) or (5152.4) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10952971,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12565835,PMID:14527714,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8786098,PMID:8884271,PMID:9210593,PMID:9419816,PMID:9624146,PMID:9716380 NOTES:NCD
product: MODEL1310110026#
reactant: MODEL1310110026#

metaM atp c
has only substance units: false
is: CHEBI:30616
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB00538
name: ATP(4-)
initial amount: NaN
is: C00002

metaM m6mpdol U r
has only substance units: false
is: SBO:0000247
name: (alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C1605H2640N20O520P20 CHARGE: -20
is: CHEBI:37635
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_326e045b_6a13_4189_840d_2329a8ad091f
constant: false
is: SBO:0000252
name: PGAP1
is encoded by: hsa:80055
is: Q75T13
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_d17ecfdd_ff8d_4ae2_9f59_3788357e9589
initial concentration: NaN
is encoded by: hsa:D29675
boundary condition: true
constant: false
initial amount: NaN
name: _D29675_1_e
has only substance units: false
is: SBO:0000252
type: Species

metaR URAt
is: SBO:0000185
reversible: true
name: uracil transport via facilated diffusion
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
fast: false
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_3ab057f0_8b3a_4fc9_acb4_36306e5f516e
initial concentration: NaN
constant: false
boundary condition: true
is: Q6IBA0
has only substance units: false
type: Species
is encoded by: hsa:4725
is: SBO:0000252
initial amount: NaN
name: NDUFS5

metaM imp e
type: Species
boundary condition: false
name: IMP(2-)
is: CHEBI:58053
is: HMDB00175
is: SBO:0000247
has only substance units: false
notes: FORMULA: C10H11N4O8P CHARGE: -2 INCHI: InChI=1S/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
constant: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110026#_c54dadaa_9241_497d_8bce_b950c36ee13c
name: ACAD9
initial concentration: NaN
is: Q9H845
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:28976

metaR O16G1e
notes: GENE_ASSOCIATION: (6476.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
modifier: MODEL1310110026#
is described by: ECO:0000000
product: MODEL1310110026#
is: SBO:0000176
name: oligo-1,6-glucosidase (glygn4 -> glygn5), extracellular
is version of: http://identifiers.org/ec-code/3.2.1.10
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110026#_d85dee55_bcd8_4985_b30a_9f0c9b249208
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
name: RPE
is: Q96AT9
is: SBO:0000252
is encoded by: hsa:6120
type: Species
initial concentration: NaN

metaR TETTET6COAtx
is described by: ECO:0000000
name: fatty acid intracellular transport
fast: false
is: SBO:0000185
reactant: MODEL1310110026#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
product: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_be4838e0_cd5c_44f3_a6c9_d77b78224472
has only substance units: false
is encoded by: hsa:26266
type: Species
is: SBO:0000252
is: Q9UKG4
initial concentration: NaN
constant: false
name: SLC13A4
boundary condition: true
initial amount: NaN

metaR EX lneldc LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoelaidic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_b27ed8e0_3c1b_4d4d_8336_f1b379bc5576
boundary condition: true
type: Species
initial amount: NaN
constant: false
name: GBA
is: SBO:0000252
is: P04062
is encoded by: hsa:2629
has only substance units: false
initial concentration: NaN

metaR r0879
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110026#
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11287335,PMID:11327718 NOTES:
reversible: false
is: SBO:0000185
name: TCDB:2.A.29.2.4 TCDB:2.A.29.16.1

metaR r2360
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
reversible: true
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110026#
is described by: ECO:0000000
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_66037a77_9323_4e71_86fb_8ec3844d39f3
is: Q15111
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
constant: false
name: PLCL1
boundary condition: true
initial amount: NaN
is encoded by: hsa:5334

metaM C04849 e
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:57449
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_7e231de2_d98b_4b91_ab27_c19b22ff7c01
constant: false
is: SBO:0000252
is: Q8NCI4
is encoded by: hsa:54872
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
name: PIGG

metaR EX biocyt LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biocytin exchange
type: Reaction

metaM ksi deg9 l
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: keratan sulfate I, degradation product 9
constant: false
type: Species
is: CHEBI:12936
is: SBO:0000247
is: HMDB00143
notes: FORMULA: C188H301N13O166S10 CHARGE: -10

metaM ksi pre3 g
initial concentration: 1.0
has only substance units: false
is: C00130
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 3
is: CHEBI:58053
boundary condition: false
constant: false
is: HMDB00175
notes: FORMULA: C93H152N6O67X CHARGE: -1
type: Species
is: SBO:0000247

metaR r0165
kinetic law: MODEL1310110026#
fast: false
reversible: false
reactant: MODEL1310110026#
is: SBO:0000176
type: Reaction
name: UTP:pyruvate O2-phosphotransferase EC:2.7.1.40
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
product: MODEL1310110026#
is described by: ECO:0000000

metaM CE2421 m
initial amount: NaN
is: HMDB02329
type: Species
is: CHEBI:30623
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
name: (3S)-3-hydroxylinoleoyl-CoA
is: SBO:0000247
constant: false
boundary condition: false

metaM 3hibutcoa m
type: Species
is: HMDB01052
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:28259
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
boundary condition: false
initial concentration: 1.0
name: (S)-3-Hydroxyisobutyryl-CoA
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_d0cd7a26_5b95_449d_91fc_e8e8a5df34b8
has only substance units: false
initial amount: NaN
is encoded by: hsa:30061
initial concentration: NaN
constant: false
is: Q9NP59
name: SLC40A1
is: SBO:0000252
type: Species
boundary condition: true

metaR PDE1
notes: GENE_ASSOCIATION: (5139.1) or (5142.1) or (5151.3) or (5153.1) or (5150.2) or (5143.1) or (5150.1) or (5137.1) or (5144.1) or (5136.2) or (5140.2) or (5151.2) or (10846.1) or (5151.5) or (5140.1) or (5141.1) or (5138.1) or (5136.1) or (5151.4) or (5151.1) or (27115.1) or (50940.1) or (8622.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10725373,PMID:10872825,PMID:10906126,PMID:10952971,PMID:11050148,PMID:11114167,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12388353,PMID:12681444,PMID:12764607,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8884271,PMID:9210593,PMID:9419816 NOTES:NCD
type: Reaction
fast: false
kinetic law: MODEL1310110026#
reversible: false
is: SBO:0000176
product: MODEL1310110026#
reactant: MODEL1310110026#
name: 3',5'-cyclic-nucleotide phosphodiesterase
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.1.4.35
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.4.17

metaR GTHPm
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.11.1.15
is version of: http://identifiers.org/ec-code/1.11.1.12
type: Reaction
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
product: MODEL1310110026#
is described by: ECO:0000269
reactant: MODEL1310110026#
name: glutathione peroxidase, mitochondria
reversible: true

metaR r2361
fast: false
reversible: true
product: MODEL1310110026#
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
name: Organic anion transporter 5 Utilized transport
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR RBTt
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
fast: false
is: SBO:0000185
reversible: false
name: ribitol transport via passive diffusion
type: Reaction
reactant: MODEL1310110026#
product: MODEL1310110026#
is described by: ECO:0000000

metaM naglc2p U c
initial concentration: 1.0
boundary condition: false
name: N-Acetyl-D-glucosaminyldiphosphodolichol, human uterine homolog
initial amount: NaN
type: Species
notes: FORMULA: C1105H1810N10O120P20 CHARGE: -20 INCHI: InChI=1S/C33H59NO12P2/c1-23(2)12-8-13-24(3)14-9-15-25(4)16-10-17-26(5)18-11-19-27(6)20-21-43-47(39,40)46-48(41,42)45-33-30(34-28(7)36)32(38)31(37)29(22-35)44-33/h12,14,16,18,27,29-33,35,37-38H,8-11,13,15,17,19-22H2,1-7H3,(H,34,36)(H,39,40)(H,41,42)/b24-14+,25-16+,26-18-/t27?,29-,30-,31-,32-,33-/m1/s1
is: CHEBI:18278
has only substance units: false
constant: false
is: SBO:0000247

metaR GUACYC
reactant: MODEL1310110026#
is: SBO:0000176
modifier: MODEL1310110026#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.6.1.2
kinetic law: MODEL1310110026#
product: MODEL1310110026#
name: guanylate cyclase
type: Reaction
notes: GENE_ASSOCIATION: (2977.1 and 2983.1) or (4882.2) or (2982.1 and 2974.1) or (2986.1) or (4882.1) or (2984.1) or (4881.1) or (2977.1 and 2974.1) or (3000.1) or (2982.1 and 2983.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.2 Confidence Level: 4 AUTHORS: PMID:10449911,PMID:10777682,PMID:11565546,PMID:11851379,PMID:1352257,PMID:14748740,PMID:15371450,PMID:7601467,PMID:7761400,PMID:7777544,PMID:7954658,PMID:8838319,PMID:9097965,PMID:9742212 NOTES:IT
reversible: false
fast: false

metaR ALDD2xm
name: aldehyde dehydrogenase (acetylaldehyde, NAD), mitochondrial
notes: GENE_ASSOCIATION: (219.1) or (217.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:18983992,PMID:18983993,PMID:19382904,PMID:19382905 NOTES:NCD. For NAD
product: MODEL1310110026#
reversible: false
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
kinetic law: MODEL1310110026#
is: SBO:0000176
modifier: MODEL1310110026#
type: Reaction
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_44852775_9189_4c34_b7ea_69f4be2f1549
is encoded by: hsa:10861
has only substance units: false
name: SLC26A1
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false

metaR RE0935E
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.1
is version of: http://identifiers.org/ec-code/3.2.1.17
is: SBO:0000176
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
kinetic law: MODEL1310110026#
is described by: ECO:0000000
name: RE0935
fast: false
reactant: MODEL1310110026#
product: MODEL1310110026#
modifier: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_75431331_3a6f_4bf5_9182_6748bf6f9471
type: Species
has only substance units: false
name: PLCE1
is: Q9P212
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:51196
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_ad2a7059_e56d_42e8_b4b9_be41e3a8957c
initial amount: NaN
is: SBO:0000252
name: HSD17B4
type: Species
is: E9PB82
is encoded by: hsa:3295
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true

metaR PRO Dtde
product: MODEL1310110026#
reversible: true
kinetic law: MODEL1310110026#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
fast: false
name: D-proline transport, extracellular
is: SBO:0000185
reactant: MODEL1310110026#
type: Reaction

metaR PTE3x
reactant: MODEL1310110026#
product: MODEL1310110026#
fast: false
reversible: false
type: Reaction
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (10965.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10944470 NOTES:NJ
is version of: http://identifiers.org/ec-code/3.1.2.2
modifier: MODEL1310110026#
is described by: ECO:0000000
is: SBO:0000176
name: peroxisomal acyl-CoA thioesterase

http://identifiers.org/biomodels.db/MODEL1310110026#_1e17a0cc_55e9_4d18_bd05_046b01693b48
constant: false
initial amount: NaN
is: P07451
is: SBO:0000252
is encoded by: hsa:761
name: CA3
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false

metaM retinal cis 13 r
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:45487
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
boundary condition: false
name: 13-cis-retinal
type: Species
constant: false
is: HMDB06220

metaR LEUKTRD4t
is: SBO:0000185
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
reactant: MODEL1310110026#
type: Reaction
name: leukotriene D4 transport
product: MODEL1310110026#

metaR S4TASE2ly
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000000
product: MODEL1310110026#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.12
modifier: MODEL1310110026#
type: Reaction
fast: false
reversible: true
name: N-acetylgalactosamine-4-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD

metaM gpi prot hs r
notes: FORMULA: C55H106N4O38P4FULLRCO2FULLR2CO2X CHARGE: 0
is: CHEBI:7896
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB00220
constant: false
name: {[(Prot-PE-Man),(PE)-Man],[PE]}-Man-GlcN-acylPI
is: SBO:0000247
is: C00249
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_28feadd3_4b7a_48c7_a619_e988eb509f4a
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2235
is: Q7KZA3
initial concentration: NaN
name: FECH
constant: false
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110026#_94523bdc_19cc_4df5_81b0_626d8ecf24f7
has only substance units: false
name: INPP5B
is: P32019
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:3633
initial concentration: NaN
type: Species
constant: false

metaR r2362
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110026#
product: MODEL1310110026#

metaM hmgcoa c
has only substance units: false
is: HMDB01375
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
is: SBO:0000247
name: Hydroxymethylglutaryl-CoA
boundary condition: false
is: CHEBI:15467
initial amount: NaN

metaR O2St
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
fast: false
name: superoxide anion transport via diffusion (extracellular)
reversible: true
product: MODEL1310110026#

metaM ksii core2 pre7 g
is: HMDB00175
is: CHEBI:58053
type: Species
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 7
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C67H108N5O51SX CHARGE: -2
is: C00130
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_f803d70c_849d_44e6_a55d_3942b6f42024
boundary condition: true
has only substance units: false
is: O94777
initial concentration: NaN
is encoded by: hsa:8818
is: SBO:0000252
name: DPM2
type: Species
constant: false
initial amount: NaN

metaR NDP10ex
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:IT
reversible: false
fast: false
type: Reaction
name: nucleoside-diphosphatase (IDP), extracellular
reactant: MODEL1310110026#
is: SBO:0000176
product: MODEL1310110026#
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.6.1.6
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110026#_79cf9d90_c6a5_45b2_94f9_a6a86641098b
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
name: _AA664770_1_m
type: Species
has only substance units: false
is encoded by: hsa:AA664770

http://identifiers.org/biomodels.db/MODEL1310110026#_0e991f5c_46bd_4b42_abef_dd406ba3e7e8
is: Q5JPA4
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:53919
type: Species
has only substance units: false
name: SLCO1C1
boundary condition: true
initial concentration: NaN

metaR r2363
fast: false
reactant: MODEL1310110026#
reversible: true
product: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaM m2gacpail hs r
notes: FORMULA: C43H78NO24PFULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
constant: false
type: Species
name: dimannosyl-glucosaminyl-acylphosphatidylinositol (H3)
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:16038
has only substance units: false

metaR r0113
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
product: MODEL1310110026#
name: UDP-N-acetyl-D-glucosamine 2-epimerase Aminosugars metabolism EC:5.1.3.14
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.1
reversible: false
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 0 AUTHORS: PMID:10431835,PMID:15748884,PMID:3740419,PMID:4337336,PMID:5063602,PMID:5417402,PMID:9305887,PMID:9305888 NOTES:
fast: false
modifier: MODEL1310110026#
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110026#_1784a9f6_d1b1_4fee_bded_7c6a8b8ba098
name: MCEE
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is: Q96PE7
is: SBO:0000252
type: Species
is encoded by: hsa:84693
initial concentration: NaN

metaR CYSGLUexR
product: MODEL1310110026#
name: L-cysteine/L-glutamine reversible exchanger
type: Reaction
modifier: MODEL1310110026#
reversible: true
is described by: ECO:0000304
fast: false
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185

metaR CYTK10n
name: cytidylate kinase (CMP,dGTP),nuclear
reactant: MODEL1310110026#
modifier: MODEL1310110026#
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
product: MODEL1310110026#

metaM 2oxoadp c
constant: false
boundary condition: false
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
is: HMDB00225
has only substance units: false
is: CHEBI:57499
initial concentration: 1.0
name: 2-oxoadipate(2-)
initial amount: NaN
is: SBO:0000247
type: Species

metaM mpdol U c
boundary condition: false
is: CHEBI:18396
constant: false
initial concentration: 1.0
type: Species
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human uterine homolog
has only substance units: false
is: SBO:0000247
notes: FORMULA: C1245H2040N20O220P20 CHARGE: -20
initial amount: NaN

metaR TETDECE1CRNe
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of tetradecenoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_4ef7adb9_c602_469f_9ec0_47cdbe3f9476
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
constant: false
name: GOT2
is: P00505
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2806

http://identifiers.org/biomodels.db/MODEL1310110026#_06d9cebe_eed9_491e_9641_d8262b2161b0
is: O75355
is encoded by: hsa:956
boundary condition: true
is: SBO:0000252
name: ENTPD3
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false

metaM lthstrl r
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:17168
boundary condition: false
is: HMDB01170
type: Species
name: 5alpha-cholest-7-en-3beta-ol
initial concentration: 1.0

metaR G5SADrm
reactant: MODEL1310110026#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110026#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
product: MODEL1310110026#
is described by: ECO:0000000

metaM nrpphr e
type: Species
is: HMDB00216
boundary condition: false
is: CHEBI:33569
initial concentration: 1.0
constant: false
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: Norepinephrine

metaM atp m
initial concentration: 1.0
is: CHEBI:57299
type: Species
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
is: HMDB00538
name: ATP(4-)
is: C00002
is: SBO:0000247

metaM octa c
is: HMDB00482
constant: false
is: C06423
initial concentration: 1.0
notes: FORMULA: C8H15O2 CHARGE: -1
boundary condition: false
type: Species
is: CHEBI:25646
has only substance units: false
name: octanoate (n-C8:0)
is: SBO:0000247
initial amount: NaN

metaR GLNLASEer
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.17 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD
product: MODEL1310110026#
fast: false
reactant: MODEL1310110026#
type: Reaction
reversible: true
name: gluconolactonase, endoplasmic reticulum
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110026#

metaR RAI1
name: retinal isomerase (11-cis)
product: MODEL1310110026#
kinetic law: MODEL1310110026#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reactant: MODEL1310110026#
fast: false
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110026#_75ce0583_63df_4eca_8d80_5ae0536cfed9
initial concentration: NaN
is: SBO:0000252
name: ALG2
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:85365

metaM fucacgalfucgalacglcgalgluside hs g
initial amount: NaN
is: CHEBI:57455
is: C00445
name: (Gal)2 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)2 (Cer)1
notes: FORMULA: C64H112N3O35FULLRCO CHARGE: 0
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01354
type: Species
boundary condition: false
constant: false

metaR ILETA
is: SBO:0000176
reversible: true
type: Reaction
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.6.1.42
is described by: ECO:0000269
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
name: isoleucine transaminase
reactant: MODEL1310110026#
product: MODEL1310110026#
fast: false

metaM cmp n
type: Species
initial concentration: 1.0
name: CMP(2-)
is: SBO:0000247
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
has only substance units: false
is: CHEBI:60377
constant: false
boundary condition: false
initial amount: NaN
is: HMDB00095

metaR ACCOAtn
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110026#
fast: false
kinetic law: MODEL1310110026#
name: acetyl-CoA transport, nuclear
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110026#

metaR EX asp L LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Aspartate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_cc7507a2_317a_401d_b8bc_3c7ab0ca9520
boundary condition: true
name: PANK4
is: Q9NVE7
is encoded by: hsa:55229
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_1f08d250_b147_49c0_91d2_5328cda1ebb7
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:22978
has only substance units: false
is: P49902
name: NT5C2
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR ADK1
reversible: true
is described by: ECO:0000269
fast: false
product: MODEL1310110026#
type: Reaction
name: adenylate kinase
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.7.4.3
kinetic law: MODEL1310110026#
is: SBO:0000176
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaM CE4792 m
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-22,24,28-30,34,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4792
is: SBO:0000247
is: CHEBI:57923
name: 3-oxo-cis-8-tetradecenoyl-CoA
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false

metaR ASPCTr
reactant: MODEL1310110026#
fast: false
product: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: true
name: aspartate carbamoyltransferase (reversible)
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.1.3.2 Confidence Level: 4 AUTHORS: PMID:2565865,PMID:8619816 NOTES:
is version of: http://identifiers.org/ec-code/2.1.3.2

metaR EX HC02204 LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b1 exchange
type: Reaction

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_7aebb6f1_7366_4a2b_907d_0a16573b7fd2
initial amount: NaN
boundary condition: true
is encoded by: hsa:AI971023
constant: false
type: Species
is: SBO:0000252
has only substance units: false
name: _AI971023_1_c
initial concentration: NaN

metaR EX digalsgalside hs LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Digalactosylceramidesulfate exchange
type: Reaction

metaR RE3005M
modifier: MODEL1310110026#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
kinetic law: MODEL1310110026#
name: RE3005
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
reactant: MODEL1310110026#
fast: false
product: MODEL1310110026#

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_043d82e9_954a_4e0e_b966_ba5ea65090f9
is: Q6ZMR3
initial amount: NaN
type: Species
is encoded by: hsa:160287
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
name: LDHAL6A

metaR GTHOm
type: Reaction
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558,PMID:15149466 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
reactant: MODEL1310110026#
reversible: false
is version of: http://identifiers.org/ec-code/1.8.1.7
is: SBO:0000176
is described by: ECO:0000254
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
product: MODEL1310110026#
fast: false
name: glutathione oxidoreductase

metaM nrpphr c
boundary condition: false
name: Norepinephrine
type: Species
is: CHEBI:33569
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB00216
is: SBO:0000247
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547

metaM HC10852 r
is: SBO:0000247
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h9-10,24-26,30-32,36,47-48H,4-8,11-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b10-9-/t26-,30-,31-,32+,36-/m1/s1 EHMN_ABBREVIATION: CE0852
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
name: palmitoleyl-CoA(4-)
is: CHEBI:61540
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_f65db5f4_cf02_4dc2_b820_37f79dd7968a
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:1633
is: SBO:0000252
initial amount: NaN
type: Species
is: P27707
name: DCK

metaM octa e
is: C06423
initial concentration: 1.0
type: Species
notes: FORMULA: C8H15O2 CHARGE: -1
boundary condition: false
is: CHEBI:25646
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
name: octanoate (n-C8:0)
is: HMDB00482

metaR AK2LGCHOLt
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.1.1.21 Confidence Level: 2 AUTHORS: PMID:2004782,PMID:2253271,PMID:8106516 NOTES:
is described by: ECO:0000269
reversible: true
type: Reaction
product: MODEL1310110026#
fast: false
name: 1-alkyl 2-acylglycerol 3-phosphocholine transport
is: SBO:0000185
reactant: MODEL1310110026#

metaM ksi deg18 l
is: SBO:0000247
constant: false
name: keratan sulfate I, degradation product 18
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C146H235N10O127S7 CHARGE: -7
boundary condition: false
is: HMDB00143
is: CHEBI:12936
type: Species

metaR r0728
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
type: Reaction
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000176
kinetic law: MODEL1310110026#
product: MODEL1310110026#

metaM co2 m
has only substance units: false
is: C00011
constant: false
initial amount: NaN
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
name: CO2
type: Species
is: HMDB01967
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16526

metaM 10fthf5glu e
is: HMDB00108
is: SBO:0000247
initial amount: NaN
type: Species
name: 10-formyltetrahydrofolate-[Glu](5)
initial concentration: 1.0
notes: FORMULA: C40H45N11O19 CHARGE: -6
is: CHEBI:16236
boundary condition: false
constant: false
has only substance units: false

metaR HSD3A2r
modifier: MODEL1310110026#
fast: false
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.1.1.225
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
is: SBO:0000176
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_66a0aa07_09ec_4992_92d2_fe27ed36b0c9
boundary condition: true
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: Q8NFF5
is encoded by: hsa:80308
is: SBO:0000252
name: FLAD1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_b8eff4d9_3bff_4e3e_91cd_f63b5257a1d7
initial amount: NaN
name: NDUFC2
is: Q549M5
type: Species
is encoded by: hsa:4718
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaM fucacgalfucgalacglcgalgluside hs e
is: C00095
constant: false
name: (Gal)2 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)2 (Cer)1
has only substance units: false
initial amount: NaN
notes: FORMULA: C64H112N3O35FULLRCO CHARGE: 0
is: CHEBI:15824
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB00660

metaR URCN
fast: false
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (131669.1) SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.49
type: Reaction
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
reversible: false
modifier: MODEL1310110026#
name: URCN
is: SBO:0000176
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110026#_3e2e5a39_e616_446c_a38f_6ae118afc05e
boundary condition: true
is encoded by: hsa:10026
initial concentration: NaN
name: PIGK
is: Q92643
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_e6e88fd3_be23_46b2_b184_6c67650728ab
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4247
is: Q10469
name: MGAT2
type: Species
has only substance units: false
boundary condition: true
constant: false

metaR ADK3
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
name: adentylate kinase (GTP)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.3
modifier: MODEL1310110026#
is described by: ECO:0000269

metaM dcdp c
name: dCDP
is: SBO:0000247
is: C00705
initial amount: NaN
is: HMDB01245
type: Species
is: CHEBI:58593
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
constant: false

metaR r2092
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
product: MODEL1310110026#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110026#

metaR r2091
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
modifier: MODEL1310110026#
fast: false
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110026#

metaM ser L e
has only substance units: false
initial amount: NaN
is: CHEBI:17115
type: Species
is: HMDB00187
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
constant: false
name: L-serine
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110026#_d59fb867_9d1c_4230_9673_1da847435572
is encoded by: hsa:6547
initial concentration: NaN
is: P57103
type: Species
name: SLC8A3
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false

metaR GTMLTe
is: SBO:0000185
name: g-glutamyltransferase (e)
is version of: http://identifiers.org/ec-code/2.3.2.2
reversible: false
kinetic law: MODEL1310110026#
fast: false
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (2679.1) or (2678.1) or (2678.3) or (2678.2) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:15469854 NOTES:NCD SAB e see Disussion section of PMID 15469854
product: MODEL1310110026#
modifier: MODEL1310110026#
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_1194733c_949e_4804_87a3_7f0eaca992ec
is: SBO:0000252
constant: false
is encoded by: hsa:1374
has only substance units: false
is: Q8WZ48
name: CPT1A
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species

metaR LEUtec
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
name: L-leucine transport via diffusion (extracellular to cytosol)
is: SBO:0000185
reactant: MODEL1310110026#
type: Reaction
modifier: MODEL1310110026#
fast: false
reversible: true
product: MODEL1310110026#
kinetic law: MODEL1310110026#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110026#_e1c07558_b0a0_46d1_befb_4feb091b4cb2
type: Species
constant: false
is: SBO:0000252
name: RDH16
is: O75452
initial amount: NaN
has only substance units: false
is encoded by: hsa:8608
initial concentration: NaN
boundary condition: true

metaM hmgcoa m
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB01375
is: CHEBI:15467
has only substance units: false
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
name: Hydroxymethylglutaryl-CoA
type: Species
constant: false
boundary condition: false

metaR MCLOR
type: Reaction
reversible: true
reactant: MODEL1310110026#
product: MODEL1310110026#
kinetic law: MODEL1310110026#
fast: false
is described by: ECO:0000269
name: 3-Mercaptolactate:NAD+ oxidoreductase
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.1.1.27
is: SBO:0000176
notes: GENE_ASSOCIATION: (92483.1) or (3945.1 and 3939.1) or (55293.1) or (3948.2) or (3948.1) or (3945.1) or (160287.1) or (3939.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:7054184 NOTES:

metaM dhap x
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3411
is: CHEBI:57642
constant: false
is: C00111
is: SBO:0000247
type: Species
name: Dihydroxyacetone phosphate
is: HMDB01473

http://identifiers.org/biomodels.db/MODEL1310110026#_d3faf38d_2eaa_41c4_be61_4dfe277293b8
boundary condition: true
name: ADCY6
is encoded by: hsa:112
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN

metaM fucacgalfucgalacglcgalgluside hs c
is: C00445
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C64H112N3O35FULLRCO CHARGE: 0
name: (Gal)2 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)2 (Cer)1
is: HMDB01354
initial amount: NaN
type: Species
is: CHEBI:57455
has only substance units: false
constant: false
boundary condition: false

metaR r2090
is: SBO:0000185
fast: false
reactant: MODEL1310110026#
reversible: true
kinetic law: MODEL1310110026#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
modifier: MODEL1310110026#
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM cholcoaone x
initial amount: NaN
is: HMDB06891
type: Species
constant: false
name: 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA(4-)
is: CHEBI:58507
is: SBO:0000247
notes: FORMULA: C48H74N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-30,32-34,36,38-40,44,56,58-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/p-4/t24-,25?,26+,27-,28-,29+,30+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01473 EHMN_ABBREVIATION: C05467
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaR NACHEX8ly
reactant: MODEL1310110026#
modifier: MODEL1310110026#
reversible: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
product: MODEL1310110026#
is described by: ECO:0000000
kinetic law: MODEL1310110026#
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR DESAT24 1
is: SBO:0000176
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.99.25 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
fast: false
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
name: fatty acyl-CoA desaturase (n-C24:5CoA -> n-C24:6CoA)
product: MODEL1310110026#

metaR r0871
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409 NOTES:
fast: false
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110026#
name: Diffusion

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

metaM 34dhmald m
initial concentration: 1.0
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
is: HMDB06242
boundary condition: false
type: Species
constant: false
has only substance units: false
name: 3,4-Dihydroxymandelaldehyde
is: http://identifiers.org/pubchem.compound/7903
initial amount: NaN
is: C05577
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110026#_0b322e01_a5f2_4d10_8e4f_58cbf0a4bff8
name: PIGS
is: SBO:0000252
is: Q8NBL9
boundary condition: true
has only substance units: false
is encoded by: hsa:94005
initial concentration: NaN
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_2df6750d_d1d3_40a7_8c7d_ae8d3c68836d
is encoded by: hsa:3632
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
name: INPP5A
is: SBO:0000252
constant: false
has only substance units: false
is: Q14642

metaR GLUDxm
kinetic law: MODEL1310110026#
product: MODEL1310110026#
name: glutamate dehydrogenase (NAD) (mitochondrial)
is version of: http://identifiers.org/ec-code/1.4.1.3
reactant: MODEL1310110026#
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
reversible: true
modifier: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_cc60af58_e2d7_4aff_ba5d_0816d5c07ac5
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:7357
constant: false
name: UGCG
type: Species
is: Q16739
initial concentration: NaN

metaR S6T7g
is: SBO:0000176
modifier: MODEL1310110026#
reactant: MODEL1310110026#
product: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110026#
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

metaR PGDI
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/5.3.99.2
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
product: MODEL1310110026#
type: Reaction
is: SBO:0000176
reversible: true
fast: false
name: Prostaglandin-H2 D-isomerase [Precursor]
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.5.1.18

metaR r0870
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.6.1.1
is version of: http://identifiers.org/ec-code/3.1.3.4
is version of: http://identifiers.org/ec-code/2.7.7.72
name: Facilitated diffusion
is version of: http://identifiers.org/ec-code/3.6.4.13
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_e37ef872_59e6_41a2_97bf_723c6d956429
is: SBO:0000252
type: Species
name: B4GALT2
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:8704
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_5d2a0988_f03b_4038_ba11_4491c9fd85bb
has only substance units: false
is encoded by: hsa:35
name: ACADS
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
is: P16219
type: Species
boundary condition: true

metaM g3p c
is: C00661
is: CHEBI:58027
is: http://identifiers.org/pubchem.compound/3930
is: SBO:0000247
is: HMDB01112
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
initial concentration: 1.0
name: Glyceraldehyde 3-phosphate
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
constant: false

metaM 2mp2coa m
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
is: HMDB01011
is: CHEBI:27754
name: 2-Methylprop-2-enoyl-CoA
has only substance units: false
type: Species

metaR C10DCCACT
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacoyl carnitine into cytosol
type: Reaction

metaR DM atp c
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
kinetic law: MODEL1310110026#
name: DM_atp(c)
is: SBO:0000176
reactant: MODEL1310110026#
is described by: ECO:0000134
fast: false
type: Reaction
reversible: false

metaR RE1520M
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110026#
reactant: MODEL1310110026#
name: RE1520
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110026#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/1.1.1.35

http://identifiers.org/biomodels.db/MODEL1310110026#_f5527806_71c8_48a2_be29_661553c1c783
type: Species
initial concentration: NaN
is encoded by: hsa:AV717590
has only substance units: false
initial amount: NaN
constant: false
name: _AV717590_1_m
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110026#_b9fdbadb_1aee_4e5a_83be_72f77fccd9f2
boundary condition: true
type: Species
has only substance units: false
name: NDUFC1
initial amount: NaN
is encoded by: hsa:4717
is: O43677
is: SBO:0000252
constant: false
initial concentration: NaN

metaR EX ksii core4 LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 4-linked) exchange
type: Reaction

metaR r0009
reactant: MODEL1310110026#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
is version of: http://identifiers.org/ec-code/3.6.1.1
kinetic law: MODEL1310110026#
is described by: ECO:0000000
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
product: MODEL1310110026#
type: Reaction
reversible: false
modifier: MODEL1310110026#

metaR RDH2a
notes: GENE_ASSOCIATION: (195814.1) or (112724.1) or (145226.1) or (51109.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12435598,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
is: SBO:0000176
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: true
fast: false
type: Reaction
name: retinol dehydrogenase (9-cis,NADPH)
is version of: http://identifiers.org/ec-code/1.1.1.105
is described by: ECO:0000269
modifier: MODEL1310110026#
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.1.1.300

http://identifiers.org/biomodels.db/MODEL1310110026#_ad9aafe3_8d21_4a00_93ec_a12be374665e
type: Species
initial concentration: NaN
is: P78356
boundary condition: true
name: PIP4K2B
has only substance units: false
is encoded by: hsa:8396
is: SBO:0000252
constant: false
initial amount: NaN

metaM 5HPET c
has only substance units: false
is: HMDB01193
name: 5(S)-HPETE(1-)
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:57450
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
type: Species
is: SBO:0000247
constant: false

metaR r0591
fast: false
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
is described by: ECO:0000000
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
is: SBO:0000176
reversible: true
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
reactant: MODEL1310110026#

metaR EX phyt LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phytanic acid exchange
type: Reaction

metaR CMPACNAtn
product: MODEL1310110026#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
is described by: ECO:0000000
name: CMP-Sia nuclear export
reversible: false
fast: false
type: Reaction

metaR r2096
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110026#
is described by: ECO:0000000
product: MODEL1310110026#
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
fast: false
type: Reaction
reversible: true
is: SBO:0000185

metaM HC00319 c
constant: false
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
is: CHEBI:30794
has only substance units: false
name: Malonate
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

metaR LNELDCt
is described by: ECO:0000000
kinetic law: MODEL1310110026#
type: Reaction
reactant: MODEL1310110026#
product: MODEL1310110026#
reversible: true
name: fatty acid transport via diffusion
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110026#_d7a6bf6d_1826_43e0_bd1b_a0861472afa5
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is: P07864
constant: false
name: LDHC
is: SBO:0000252
is encoded by: hsa:3948

http://identifiers.org/biomodels.db/MODEL1310110026#_a14a45ea_4033_4a72_be6f_30d5e24a3f62
boundary condition: true
constant: false
type: Species
initial amount: NaN
is: P33316
name: DUT
is encoded by: hsa:1854
has only substance units: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110026#_5744d08c_6e07_4d9b_bdc9_4e4c16f5420d
initial amount: NaN
constant: false
is: O43451
boundary condition: true
has only substance units: false
is encoded by: hsa:8972
type: Species
initial concentration: NaN
is: SBO:0000252
name: MGAM

http://identifiers.org/biomodels.db/MODEL1310110026#_97559d44_814c_4e07_b271_c47394f87b5a
has only substance units: false
is encoded by: hsa:1718
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial concentration: NaN
name: DHCR24
is: Q15392

metaM HC02217 e
constant: false
name: prostaglandin-g2
has only substance units: false
is: CHEBI:27647
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
initial amount: NaN
is: SBO:0000247

metaR RE3347C
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110026#
product: MODEL1310110026#
is: SBO:0000176
name: RE3347
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:

metaR r1674
name: Y+LAT2 Utilized transport
is: SBO:0000185
fast: false
modifier: MODEL1310110026#
reversible: false
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110026#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110026#

metaR CHSTEROLt1
product: MODEL1310110026#
is: SBO:0000185
kinetic law: MODEL1310110026#
type: Reaction
fast: false
name: cholesterol intracellular transport
modifier: MODEL1310110026#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?
reversible: true
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_3d5f6f39_57b9_4c59_b120_e13fc7568ee5
has only substance units: false
initial concentration: NaN
is: Q96QD8
name: SLC38A2
is encoded by: hsa:54407
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
constant: false

metaM ksi l
boundary condition: false
initial concentration: 1.0
is: CHEBI:57455
has only substance units: false
type: Species
name: keratan sulfate I
constant: false
is: HMDB01354
initial amount: NaN
is: C00445
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
is: SBO:0000247

metaR r0590
modifier: MODEL1310110026#
is described by: ECO:0000000
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
type: Reaction
is: SBO:0000176
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
reversible: false
product: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_d395d70e_7cba_461a_b53f_c84b9660cb71
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
name: _LOC727762_1_m
constant: false
type: Species
is encoded by: hsa:LOC727762

http://identifiers.org/biomodels.db/MODEL1310110026#_cbdbd4f4_ca8e_4f71_b356_d243052f251f
is encoded by: hsa:6240
boundary condition: true
is: SBO:0000297
constant: false
type: Species
is encoded by: hsa:6241
has part: P23921
has only substance units: false
initial amount: NaN
has part: P31350
initial concentration: NaN
name: RRM1:RRM2

metaR r0722
kinetic law: MODEL1310110026#
product: MODEL1310110026#
type: Reaction
modifier: MODEL1310110026#
fast: false
reactant: MODEL1310110026#
is described by: ECO:0000000
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.3.12
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reversible: true

metaR r2095
is described by: ECO:0000000
reactant: MODEL1310110026#
product: MODEL1310110026#
is: SBO:0000185
fast: false
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110026#
reversible: true
kinetic law: MODEL1310110026#

metaM pdx5p c
initial concentration: 1.0
is: CHEBI:58589
name: Pyridoxine 5'-phosphate
has only substance units: false
initial amount: NaN
type: Species
is: HMDB01319
constant: false
is: SBO:0000247
boundary condition: false
is: C00627
notes: FORMULA: C8H10NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00459 EHMN_ABBREVIATION: C00627

metaM cmp g
type: Species
initial concentration: 1.0
is: CHEBI:60377
initial amount: NaN
name: CMP(2-)
is: SBO:0000247
constant: false
is: HMDB00095
boundary condition: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_e8cc174b_3042_480b_9db6_94519d4a9544
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:25902
constant: false
is: B2RD24
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: MTHFD1L

http://identifiers.org/biomodels.db/MODEL1310110026#_982db406_46f4_40a5_afd5_5685942651ce
is encoded by: hsa:1593
constant: false
is: SBO:0000252
name: CYP27A1
type: Species
initial concentration: NaN
is: Q02318
initial amount: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110026#_b6640a81_7adf_479a_bb42_561baeb5e65e
is: Q05932
constant: false
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2356
initial amount: NaN
name: FPGS
is: SBO:0000252
has only substance units: false

metaM ser L c
is: HMDB00187
is: CHEBI:17115
has only substance units: false
name: L-serine
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
initial concentration: 1.0
constant: false
initial amount: NaN

metaR r1671
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
name: Y+LAT2 Utilized transport
product: MODEL1310110026#
modifier: MODEL1310110026#
fast: false
reversible: true
is: SBO:0000185

metaR O2t
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
reactant: MODEL1310110026#
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110026#
kinetic law: MODEL1310110026#
is: SBO:0000185
name: o2 transport (diffusion)

metaM dcdp n
has only substance units: false
is: CHEBI:58593
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01245
name: dCDP(3-)
is: SBO:0000247
boundary condition: false
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705

metaM ddece1crn e
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C19H35NO4 CHARGE: 0
boundary condition: false
is: HMDB00791
name: dodecenoyl carnitine
type: Species
is: C02838
initial amount: NaN
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110026#_7aeb6b06_93b6_4035_adf1_d4965bd14a8e
is encoded by: hsa:3028
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q99714
initial concentration: NaN
name: HSD17B10
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110026#_04257d41_1490_44fc_bb40_cefbb9205afa
has only substance units: false
boundary condition: true
name: SLC24A4
is encoded by: hsa:123041
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false

metaM co2 e
constant: false
type: Species
is: CHEBI:16526
initial amount: NaN
initial concentration: 1.0
name: CO2
boundary condition: false
is: HMDB01967
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
has only substance units: false
is: SBO:0000247
is: C00011

metaM cmp e
constant: false
type: Species
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
initial amount: NaN
initial concentration: 1.0
is: CHEBI:60377
boundary condition: false
is: HMDB00095
has only substance units: false
name: CMP(2-)
is: SBO:0000247

metaR DPPS
is described by: ECO:0000134
kinetic law: MODEL1310110026#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: Confidence Level: 2 AUTHORS: PMID:16262699 NOTES:by analogy to other dimethyl transferase rxns. See PMID: 10586494, human interemidate (from C15 ->C50) not explicitly determined yet, however it is known to occur since this pathway is essential in Q10 synthesis. For human metabolism: may be associated w/ GeneID: 23590 TPRT - recheck lit in future IT and NJ
product: MODEL1310110026#
name: decaprenyl synthase
reactant: MODEL1310110026#
type: Reaction
fast: false

metaM retinal cis 9 c
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
initial amount: NaN
constant: false
is: HMDB01358
initial concentration: 1.0
is: CHEBI:17898
has only substance units: false
boundary condition: false
name: all-trans-retinal
is: SBO:0000247
type: Species

metaR r2094
fast: false
product: MODEL1310110026#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110026#
type: Reaction
modifier: MODEL1310110026#
reactant: MODEL1310110026#

metaR ACALDt
name: acetaldehyde reversible transport
is described by: ECO:0000000
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
product: MODEL1310110026#
reactant: MODEL1310110026#
reversible: true
type: Reaction
is: SBO:0000185

metaR GALASE3ly
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
modifier: MODEL1310110026#
name: beta-galactosidase, lysosomal
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110026#
fast: false
type: Reaction
kinetic law: MODEL1310110026#

metaM datp n
type: Species
initial concentration: 1.0
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
has only substance units: false
initial amount: NaN
constant: false
name: dATP
is: C00131
is: HMDB01532
is: SBO:0000247
boundary condition: false
is: CHEBI:61404

http://identifiers.org/biomodels.db/MODEL1310110026#_cb6fe154_5e2d_447d_a97a_553f67a6b5d6
is encoded by: hsa:30
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is: Q96CA6
initial amount: NaN
name: ACAA1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110026#_e2248e78_77d7_440c_bf9a_2609b3e84c55
boundary condition: true
name: PCBD2
has only substance units: false
constant: false
is encoded by: hsa:84105
is: Q9H0N5
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species

metaM tdcoa c
is: HMDB01521
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: C02593
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
boundary condition: false
is: CHEBI:57385
constant: false
initial amount: NaN
name: Tetradecanoyl-CoA (n-C14:0CoA)
type: Species

metaR FAOXC3DC
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: malonylcoa-->malonylcarnitine
type: Reaction

metaM HC02217 c
initial amount: NaN
is: SBO:0000247
name: prostaglandin-g2
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
is: CHEBI:27647
boundary condition: false
type: Species

metaR r0720
name: (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
product: MODEL1310110026#
reversible: false
type: Reaction
kinetic law: MODEL1310110026#
is described by: ECO:0000000
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_cc40390d_3b92_4208_a848_c6e6e020a9f8
is: SBO:0000252
type: Species
is: P23786
constant: false
has only substance units: false
is encoded by: hsa:1376
name: CPT2
boundary condition: true
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_59e3fc63_c995_4b9b_bdb2_4f29b720b2d6
is: Q02742
name: GCNT1
is encoded by: hsa:2650
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_1972a6e8_090b_4d6d_aa45_30507c49cb74
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
is: P05166
is encoded by: hsa:5096
has only substance units: false
name: PCCB
initial concentration: NaN
constant: false

metaR GGH 6THFe
product: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reversible: false
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
modifier: MODEL1310110026#
type: Reaction
is described by: ECO:0000000
name: Gamma-glutamyl hydrolase (6THF), extracellular
is version of: http://identifiers.org/ec-code/3.4.19.9
is: SBO:0000176

metaR r2093
is described by: ECO:0000000
product: MODEL1310110026#
reactant: MODEL1310110026#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
modifier: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
reversible: true

metaR TETDEC2CRNe
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of tetradecadienoyl carnitine into extra cellular space
type: Reaction

metaR GPIMTer U
type: Reaction
reversible: false
reactant: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: (93183.1) and (54965.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11226175,PMID:15635094 NOTES:NCD
modifier: MODEL1310110026#
product: MODEL1310110026#
kinetic law: MODEL1310110026#
is: SBO:0000176
name: GlcN-acylPI mannosyltransferase, endoplasmic reticulum
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110026#_192a2bff_ebc0_42ca_a31e_1db86cb291b1
is encoded by: hsa:9374
type: Species
has only substance units: false
name: PPT2
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: Q9UMR5
constant: false

metaR r1957
kinetic law: MODEL1310110026#
type: Reaction
reactant: MODEL1310110026#
name: Y+LAT2 Utilized transport
product: MODEL1310110026#
is: SBO:0000185
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110026#_5749ccf9_af1e_4d4f_90dc_d19fdee12a31
has only substance units: false
boundary condition: true
initial concentration: NaN
is: O14841
name: OPLAH
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:26873
constant: false

metaM cmp c
initial concentration: 1.0
is: C00055
constant: false
boundary condition: false
name: CMP
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:60377
is: HMDB00095
is: SBO:0000247
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055

metaM co2 c
is: C00011
initial concentration: 1.0
is: CHEBI:3313
constant: false
boundary condition: false
name: CO2
type: Species
notes: FORMULA: CO2 CHARGE: 0
initial amount: NaN
is: HMDB01967
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110026#_a9b8e915_03d1_45c1_8663_bf6725f3cedf
boundary condition: true
is: D6RDW3
has only substance units: false
initial amount: NaN
constant: false
name: GUCY1A3
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:2982

metaR G14T19g
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110026#
reversible: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.4.1.90
notes: GENE_ASSOCIATION: (9334.1) or (8704.1) or (8703.1) or (8704.2) or (2683.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
modifier: MODEL1310110026#

metaR G6PDH2rer
type: Reaction
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.1.1.47
is: SBO:0000176
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:NCD
reactant: MODEL1310110026#
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum
reversible: true
kinetic law: MODEL1310110026#
product: MODEL1310110026#

metaR AG13T11g
is: SBO:0000176
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
product: MODEL1310110026#
is described by: ECO:0000000
type: Reaction

metaM ksi deg26 l
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C110H179N7O93S4 CHARGE: -4
constant: false
has only substance units: false
is: CHEBI:58343
name: keratan sulfate I, degradation product 26
is: HMDB00061
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110026#_bf0c977e_b669_4efe_a84f_dad6e63e1c67
is encoded by: hsa:7359
type: Species
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: _7359_1_c
has only substance units: false

metaR r1958
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110026#
name: Y+LAT2 Utilized transport
type: Reaction
product: MODEL1310110026#
reactant: MODEL1310110026#
modifier: MODEL1310110026#

metaM ksii core2 pre10 g
type: Species
name: keratan sulfate II biosynthesis, precursor 10
initial concentration: 1.0
constant: false
is: CHEBI:28067
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C81H130N6O64S2X CHARGE: -3

metaR FUCACGALFUCGALACGLCGALGLUSIDEtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
name: blood group intracellular transport
is: SBO:0000185
reversible: true
type: Reaction
product: MODEL1310110026#
is described by: ECO:0000000
reactant: MODEL1310110026#
fast: false
kinetic law: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_1a5d3d94_6603_4fb8_9ad5_b8861b3750fe
is: O14521
boundary condition: true
has only substance units: false
is encoded by: hsa:6392
is: SBO:0000252
type: Species
name: SDHD
initial concentration: NaN
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_6b9b3ee7_bd74_4655_9e6b_dd5cd80a14be
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: SLC4A4
is encoded by: hsa:8671
type: Species
boundary condition: true
initial amount: NaN
constant: false
is: A5JJ20

metaM atp r
is: C00002
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB00538
is: CHEBI:57299
type: Species
constant: false
name: ATP(4-)
initial amount: NaN
initial concentration: 1.0

metaM dcdp m
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
has only substance units: false
boundary condition: false
is: CHEBI:58593
is: HMDB01245
name: dCDP(3-)

metaR FUCACGALFUCGALACGLCGALGLUSIDEte
type: Reaction
kinetic law: MODEL1310110026#
reversible: true
product: MODEL1310110026#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
reactant: MODEL1310110026#
fast: false
name: blood group intracellular transport
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110026#_5365a1bb_5e36_4763_9b72_122237a8ebb8
type: Species
name: SLC6A2
is: SBO:0000252
is encoded by: hsa:6530
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is: Q96KH8

metaR UMPK7n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110026#
name: UMP kinase (dGTP),nuclear
reversible: true
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
type: Reaction
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_7bd631a1_0bd7_4b13_b7b4_f0265daed500
is encoded by: hsa:80704
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
is: Q9BZV2
has only substance units: false
name: SLC19A3
boundary condition: true

metaR r1959
name: Y+LAT2 Utilized transport
type: Reaction
fast: false
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000000

metaR r1806
modifier: MODEL1310110026#
product: MODEL1310110026#
name: Y+LAT2 Utilized transport
reversible: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110026#_2a95a095_41b9_4826_83bf_6a01ae898606
is: B4DIA3
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:6535
boundary condition: true
name: SLC6A8

metaM ksi g
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB01014
constant: false
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
name: keratan sulfate I
is: CHEBI:57255
initial amount: NaN

metaR r2099
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reactant: MODEL1310110026#
product: MODEL1310110026#
reversible: true
kinetic law: MODEL1310110026#
fast: false
modifier: MODEL1310110026#
is described by: ECO:0000000
is: SBO:0000185

metaR r0726
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
type: Reaction
modifier: MODEL1310110026#
is described by: ECO:0000000
product: MODEL1310110026#
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is version of: http://identifiers.org/ec-code/2.7.1.33
is: SBO:0000176
reversible: true
fast: false
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_791dffd8_12c4_4ab6_9fed_95b6bc28cb9a
has only substance units: false
name: LCT
initial concentration: NaN
is: P09848
type: Species
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:3938

metaM 2oxoadp m
constant: false
boundary condition: false
name: 2-oxoadipate(2-)
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
is: CHEBI:57499
is: HMDB00225
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0

metaR NACHEX22ly
is: SBO:0000176
kinetic law: MODEL1310110026#
type: Reaction
product: MODEL1310110026#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110026#
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

metaR LPS
notes: GENE_ASSOCIATION: (4023.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.3 Confidence Level: 4 AUTHORS: PMID:1969408 NOTES:carbonyl and extra H accounted for in R group NJ
is: SBO:0000176
product: MODEL1310110026#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.1.34
name: lipase
reactant: MODEL1310110026#
fast: false
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
reversible: false
type: Reaction

metaR CHSTEROLt2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
type: Reaction
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is: SBO:0000185
product: MODEL1310110026#
reversible: true
fast: false
is described by: ECO:0000000
name: cholesterol intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110026#_539bf37f_d7bf_4445_ae36_8aa02c099b15
constant: false
name: PDE6B
boundary condition: true
initial amount: NaN
is: B7Z9T9
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:5158

metaM atp n
initial concentration: 1.0
constant: false
is: CHEBI:57299
is: HMDB00538
name: ATP(3-)
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
has only substance units: false

metaR GALASE5ly
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110026#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
fast: false
kinetic law: MODEL1310110026#
name: beta-galactosidase, lysosomal

metaR r0002
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
is: SBO:0000185
product: MODEL1310110026#
is described by: ECO:0000000
fast: false
name: Active transport
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_639b9005_97c0_4b7f_adbc_71ccd9da7081
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is: P09622
boundary condition: true
name: DLD
type: Species
is encoded by: hsa:1738
is: SBO:0000252

metaR r2098
is described by: ECO:0000000
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
fast: false
product: MODEL1310110026#
type: Reaction
is: SBO:0000185
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_aadac3d1_22ee_43be_91d1_c13c77b2546a
is: Q6P1M0
has only substance units: false
name: SLC27A4
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:10999
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaM cpppg3 c
initial concentration: 1.0
is: C03263
is: SBO:0000247
is: CHEBI:57309
is: HMDB01261
has only substance units: false
boundary condition: false
type: Species
constant: false
name: Coproporphyrinogen III
initial amount: NaN
notes: FORMULA: C36H40N4O8 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01085 EHMN_ABBREVIATION: C03263

metaR CHSTEROLt3
reactant: MODEL1310110026#
is: SBO:0000185
kinetic law: MODEL1310110026#
fast: false
type: Reaction
product: MODEL1310110026#
name: cholesterol intracellular transport
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

http://identifiers.org/biomodels.db/MODEL1310110026#_b2877654_e0dc_4fdb_9fa9_0eeab0c872a3
is encoded by: hsa:115019
initial concentration: NaN
has only substance units: false
boundary condition: true
is: Q7LBE3
name: SLC26A9
type: Species
is: SBO:0000252
constant: false
initial amount: NaN

metaM oxa m
has only substance units: false
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
is: CHEBI:30623
initial amount: NaN
boundary condition: false
is: HMDB02329
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
name: oxalate(2-)

metaR r0724
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
type: Reaction
fast: false
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.33
is: SBO:0000176
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reversible: true

metaM ksi e
initial amount: NaN
boundary condition: false
is: HMDB00211
type: Species
initial concentration: 1.0
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
is: CHEBI:17268
name: keratan sulfate I
is: SBO:0000247
constant: false
has only substance units: false

metaR r2097
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110026#
product: MODEL1310110026#
type: Reaction
reversible: true
reactant: MODEL1310110026#
modifier: MODEL1310110026#
fast: false

metaM acgpail hs c
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
name: 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(1-)
type: Species
notes: FORMULA: C17H29NO14PFULLRCO2FULLR2CO2 CHARGE: -1 EHMN_ABBREVIATION: C01288
is: CHEBI:57265
has only substance units: false

metaR EX HC01361 LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Dihydroneopterin
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_8eed5f81_b8b4_4f0d_bcb0_c1898fc9bae4
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:125965
is: Q6YFQ2
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
name: COX6B2

metaM utp c
has only substance units: false
constant: false
is: CHEBI:46398
is: SBO:0000247
is: C00075
initial amount: NaN
is: HMDB00285
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
name: UTP
initial concentration: 1.0
boundary condition: false
type: Species

metaR D3AIBTm
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
product: MODEL1310110026#
kinetic law: MODEL1310110026#
is: SBO:0000176
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
type: Reaction
reactant: MODEL1310110026#
is described by: ECO:0000000
reversible: true
fast: false

metaR r2358
name: Organic anion transporter 5 Utilized transport
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110026#
is: SBO:0000185
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110026#
type: Reaction
fast: false

metaM ttdca e
is: HMDB00806
is: C06424
initial amount: NaN
notes: FORMULA: C14H27O2 CHARGE: -1 EHMN_ABBREVIATION: C06424
name: tetradecanoate (n-C14:0)
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:30807

http://identifiers.org/biomodels.db/MODEL1310110026#_f1a42a0e_5fd6_4bac_b97a_687c3891ae2e
is: SBO:0000252
is encoded by: hsa:375056
name: MIA3
constant: false
is: Q5JRA6
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_27e5f67c_ac99_484b_8eb2_4561b888f962
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:7991
initial concentration: NaN
name: TUSC3
constant: false

metaM thp2c c
boundary condition: false
constant: false
initial concentration: 1.0
name: 1-piperideine-6-carboxylate
initial amount: NaN
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB12130
is: CHEBI:16987

metaR OLEICFATPtc
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of octadecenoate by the enterocytes
type: Reaction

metaR URATEt
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110026#
product: MODEL1310110026#
name: urate export from cytosol
is: SBO:0000185
reactant: MODEL1310110026#

metaR r0191
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.2.1.24
fast: false
reversible: false
is: SBO:0000176
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (7915.1) or (9856.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275,PMID:4276999 NOTES:
name: UTP:D-fructose-6-phosphate 1-phosphotransferase EC:2.7.1.11
type: Reaction
is described by: ECO:0000000

metaM mercppyr c
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
name: 3-mercaptopyruvate
is: CHEBI:57678
notes: FORMULA: C3H3O3S CHARGE: -1 INCHI: InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00600 EHMN_ABBREVIATION: C00957
boundary condition: false
has only substance units: false
is: HMDB01368
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_e1b2d644_b60d_40c4_85aa_32ff5e5dbfa7
is: Q02318
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:1593
name: CYP27A1
is: SBO:0000252
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_96e4d544_a215_4bf5_a77a_00bf59148dc2
is: Q6I9V5
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:293
type: Species
is: SBO:0000252
name: SLC25A6

http://identifiers.org/biomodels.db/MODEL1310110026#_6669e753_164b_4ce8_a950_354e6997ea63
type: Species
boundary condition: true
constant: false
initial amount: NaN
name: NME1
has only substance units: false
is: P15531
initial concentration: NaN
is encoded by: hsa:4830
is: SBO:0000252

metaR r2359
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110026#
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110026#
fast: false
reversible: true
kinetic law: MODEL1310110026#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_9f838c08_61f4_4152_847b_6b2490e7124a
type: Species
constant: false
is encoded by: hsa:5281
is: Q07326
has only substance units: false
name: PIGF
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

metaM 5aop c
type: Species
is: C00430
initial concentration: 1.0
has only substance units: false
is: HMDB01149
initial amount: NaN
is: CHEBI:17549
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
name: 5-Amino-4-oxopentanoate

metaM 10fthf m
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: HMDB00972
is: SBO:0000247
name: 10-formyltetrahydrofolate(2-)
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:57454
type: Species

metaM CE5236 c
boundary condition: false
initial amount: NaN
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
name: O2'-4a-cyclic-tetrahydrobiopterin
is: SBO:0000247
is: CHEBI:28002
is: HMDB03952

metaM utp e
is: CHEBI:46398
is: HMDB00285
initial amount: NaN
name: UTP(4-)
type: Species
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0

metaR TKT2
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
is described by: ECO:0000000
name: transketolase
type: Reaction
kinetic law: MODEL1310110026#
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.2.1.1
reversible: true
is: SBO:0000176
fast: false
reactant: MODEL1310110026#
modifier: MODEL1310110026#

metaM ttdca c
is: CHEBI:30807
is: HMDB00806
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
constant: false
notes: FORMULA: C14H27O2 CHARGE: -1 INCHI: InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)/p-1 EHMN_ABBREVIATION: C06424
name: myristate
is: SBO:0000247
boundary condition: false

metaR DM core7 g
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM core7(g)
type: Reaction

metaR r2356
kinetic law: MODEL1310110026#
type: Reaction
reactant: MODEL1310110026#
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
fast: false
reversible: true
product: MODEL1310110026#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR ATP2ter
kinetic law: MODEL1310110026#
is: SBO:0000185
fast: false
reactant: MODEL1310110026#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: true
name: AMP/ATP transporter, endoplasmic reticulum
product: MODEL1310110026#
type: Reaction

metaR r0193
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
is: SBO:0000176
reactant: MODEL1310110026#
reversible: true
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
product: MODEL1310110026#
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110026#

metaM 4fumacac c
is: CHEBI:18034
is: HMDB01268
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: 4-fumarylacetoacetate(2-)
type: Species
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1+ HEPATONET_1.0_ABBREVIATION: HC00648 EHMN_ABBREVIATION: C01061
has only substance units: false
initial amount: NaN
constant: false

metaR G14T3g
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
is described by: ECO:0000000
reversible: false
is: SBO:0000176
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110026#
kinetic law: MODEL1310110026#
fast: false
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90

metaR r2357
type: Reaction
reactant: MODEL1310110026#
is: SBO:0000185
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport

metaR TKT1
kinetic law: MODEL1310110026#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.2.1.1
type: Reaction
name: transketolase
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
is: SBO:0000176
fast: false
product: MODEL1310110026#
reactant: MODEL1310110026#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110026#_e3cf2037_3494_4348_9c0f_aaf7f5c706a6
constant: false
is: P61457
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:5092
has only substance units: false
name: PCBD1
initial concentration: NaN
is: SBO:0000252

metaM dhf l
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
initial amount: NaN
initial concentration: 1.0
is: HMDB01056
is: CHEBI:57451
is: SBO:0000247
name: dihydrofolate(2-)
constant: false
has only substance units: false
type: Species
boundary condition: false

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

metaR r0552
reactant: MODEL1310110026#
type: Reaction
reversible: true
product: MODEL1310110026#
modifier: MODEL1310110026#
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.5.1
fast: false
kinetic law: MODEL1310110026#

metaR IDOURte
kinetic law: MODEL1310110026#
is: SBO:0000185
is described by: ECO:0000134
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
fast: false
reversible: true
name: L-iduronate transport, extracellular
reactant: MODEL1310110026#

metaR O16G2e
is version of: http://identifiers.org/ec-code/3.2.1.10
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (6476.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
name: oligo-1,6-glucosidase (strch2 ->strch3), extracellular
reactant: MODEL1310110026#

metaR r2354
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110026#
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
type: Reaction

metaM apoC Lys btn c
is: HMDB00182
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:32551
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
constant: false
notes: FORMULA: C16H27N4O3SX CHARGE: 0
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_7161d510_4242_4b0f_85c7_6a215b1d4aba
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
is encoded by: hsa:513
initial concentration: NaN
is: SBO:0000297
has only substance units: false
type: Species
constant: false
boundary condition: true
is encoded by: hsa:514
initial amount: NaN

metaR r2089
kinetic law: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110026#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
type: Reaction
product: MODEL1310110026#
modifier: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_7bdc50b1_1f31_487a_b7ef_8a82e6a080e3
is: Q01415
name: GALK2
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2585
boundary condition: true
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_fa38d294_7662_4985_9712_ac23c3831513
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:R33828
initial amount: NaN
name: _R33828_1_c
is: SBO:0000252
has only substance units: false
boundary condition: true

metaM subeac c
is: SBO:0000247
name: suberic acid
initial amount: NaN
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C8H12O4 CHARGE: -2
is: HMDB00893

metaR r0998
reactant: MODEL1310110026#
fast: false
name: Facilitated diffusion
kinetic law: MODEL1310110026#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reversible: true
is: SBO:0000185

metaR RE2677G
is described by: ECO:0000000
reactant: MODEL1310110026#
is: SBO:0000176
kinetic law: MODEL1310110026#
name: RE2677
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:
reversible: false
product: MODEL1310110026#
fast: false

metaR NACHEX9ly
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
type: Reaction
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
is: SBO:0000176
fast: false
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_b349aa5a_1755_44e4_95dc_2eb728de990e
has only substance units: false
constant: false
is: P30837
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: ALDH1B1
is encoded by: hsa:219
initial amount: NaN

metaM dhf m
is: HMDB01056
type: Species
has only substance units: false
is: CHEBI:57451
initial amount: NaN
initial concentration: 1.0
name: dihydrofolate(2-)
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415

metaR r0553
reactant: MODEL1310110026#
reversible: true
product: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
is described by: ECO:0000000
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:

metaM lnlncgcoa c
is: SBO:0000247
has only substance units: false
is: HMDB06368
name: gamma-linolenoyl-CoA(4-)
type: Species
is: CHEBI:57363
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
boundary condition: false

metaR r2355
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
fast: false
product: MODEL1310110026#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110026#
reversible: true
kinetic law: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_cd504800_40e9_419d_835a_5a23c63c93ab
initial amount: NaN
is encoded by: hsa:1635
type: Species
has only substance units: false
is: P32321
is: SBO:0000252
name: DCTD
initial concentration: NaN
constant: false
boundary condition: true

metaM tdcoa m
initial concentration: 1.0
is: SBO:0000247
is: C02593
is: HMDB01521
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:57385
constant: false
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
name: Tetradecanoyl-CoA (n-C14:0CoA)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_b5f45249_5900_475f_867c_4718bc57c923
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:4882
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
is: P20594
name: NPR2

metaR GLCAASE9ly
is version of: http://identifiers.org/ec-code/3.2.1.31
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110026#
modifier: MODEL1310110026#
name: beta-glucuronidase, lysosomal
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
kinetic law: MODEL1310110026#
reversible: false
fast: false
reactant: MODEL1310110026#

metaR ATPS4m
reversible: false
is described by: ECO:0000134
fast: false
is version of: http://identifiers.org/ec-code/3.6.3.14
notes: GENE_ASSOCIATION: (513.1 and 498.2 and 506.1 and 509.2 and 514.1 or 498.2 and 513.2 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 514.2 and 506.1 or 498.2 and 513.2 and 506.1 and 509.2 and 514.1 or 513.2 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 498.1 and 506.1 and 509.2 and 514.1 or 513.1 and 498.2 and 514.2 and 506.1 and 509.2 or 513.1 and 498.2 and 509.1 and 506.1 and 514.1 or 498.2 and 509.1 and 513.2 and 506.1 and 514.1 or 513.2 and 498.1 and 506.1 and 509.2 and 514.1 or 513.2 and 514.2 and 506.1 and 509.2 and 498.3 or 513.2 and 506.1 and 509.2 and 498.3 and 514.1 or 513.1 and 509.1 and 506.1 and 498.3 and 514.1 or 509.1 and 513.2 and 514.2 and 506.1 and 498.3 or 513.1 and 498.2 and 509.1 and 514.2 and 506.1 or 513.1 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 506.1 and 514.1 or 513.1 and 506.1 and 509.2 and 498.3 and 514.1 or 509.1 and 513.2 and 506.1 and 498.3 and 514.1 or 513.1 and 514.2 and 506.1 and 509.2 and 498.3 or 509.1 and 513.2 and 498.1 and 506.1 and 514.1 or 513.1 and 509.1 and 514.2 and 506.1 and 498.3 or 498.2 and 509.1 and 513.2 and 514.2 and 506.1 or 509.1 and 513.2 and 498.1 and 514.2 and 506.1) and (10632.1 and 4905.1 and 10476.1 and 9551.3 and 522.5 and 516.2 and 521.1 and 515.1 or 518.3 and 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 9551.3 and 522.3 or 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 517.2 and 9551.2 and 522.3 or 10632.1 and 4905.1 and 10476.1 and 522.5 and 9551.2 and 518.2 and 521.1 and 515.1 or 4905.1 and 515.2 and 10476.2 and 516.2 and 521.1 and 10632.1 and 9551.3 and 522.5 or 518.3 and 4905.1 and 9551.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 522.4 or 10632.1 and 4905.1 and 10476.1 and 9551.1 and 522.2 and 515.2 and 518.2 and 521.1 or 518.3 and 10632.1 and 4905.1 and 10476.1 and 515.3 and 9551.2 and 522.4 and 521.1 or 10632.1 and 4905.1 and 10476.1 and 515.3 and 522.2 and 9551.3 and 518.2 and 521.1 or 4905.1 and 9551.1 and 10476.2 and 522…
name: ATP synthase (four protons for one ATP)
modifier: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.6.1.14
is version of: http://identifiers.org/ec-code/3.6.4.6
is: SBO:0000185
product: MODEL1310110026#

metaR r0999
name: Facilitated diffusion
reversible: true
kinetic law: MODEL1310110026#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
product: MODEL1310110026#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110026#
fast: false

metaM datp c
is: HMDB01532
is: CHEBI:61404
name: dATP
is: C00131
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
constant: false
initial concentration: 1.0
is: SBO:0000247

metaR r0196
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reversible: true
is version of: http://identifiers.org/ec-code/3.6.1.5
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
fast: false
is: SBO:0000176
modifier: MODEL1310110026#

metaM xoltriol m
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01457
type: Species
boundary condition: false
is: CHEBI:16496

metaM xol7ah3 m
constant: false
name: 5beta-cholestane-3alpha,7alpha,26-triol
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
has only substance units: false
is: HMDB12455
is: SBO:0000247
is: CHEBI:28540
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110026#_be8c6b58_92f3_4366_9bb4_d8dcf706a0a6
name: SLC43A1
type: Species
is encoded by: hsa:8501
is: O75387
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN

metaR 2HCO3 NAt
name: bicarbonate transport (Na/HCO3 1:2 cotransport)
is described by: ECO:0000269
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110026#
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (57835.3) or (8671.1) or (57835.2) or (57835.1) or (57835.4) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
reversible: true
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#

metaR CMPSAS
is: SBO:0000176
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.7.43
type: Reaction
product: MODEL1310110026#
name: CMP sialic acid synthase
reactant: MODEL1310110026#
is described by: ECO:0000304
kinetic law: MODEL1310110026#
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110026#_29620fc0_3e8d_4ccb_9f70_b8b2434254a1
is: SBO:0000252
type: Species
initial concentration: NaN
name: NDUFB10
initial amount: NaN
constant: false
is: A8K761
boundary condition: true
is encoded by: hsa:4716
has only substance units: false

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

metaR r2352
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
product: MODEL1310110026#
kinetic law: MODEL1310110026#
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110026#
reversible: true

metaM pydxn c
is: CHEBI:16709
name: Pyridoxine
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
is: C00314
has only substance units: false
constant: false
is: HMDB00239
notes: FORMULA: C8H11NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00268 EHMN_ABBREVIATION: C00314
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_ca305a1c_051a_44c5_80c9_9f91dec13751
has only substance units: false
name: FUT8
is encoded by: hsa:2530
boundary condition: true
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
is: Q546E0
initial concentration: NaN

metaR DOLPGT1 Uer
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (29929.1) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10359825 NOTES:EC 2.4.1.- NCD
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.4.1.267
fast: false
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
is: SBO:0000176
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
type: Reaction

metaR UDPGLCAter
product: MODEL1310110026#
is described by: ECO:0000269
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
fast: false
is: SBO:0000185
reversible: true
type: Reaction
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
name: UDPGlcA endoplasmic reticulum transport via UMP antiport

http://identifiers.org/biomodels.db/MODEL1310110026#_862af5b0_9ec7_45a5_88fd_fcdd1b7a90a1
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
is: B2R6S5
constant: false
is encoded by: hsa:51727
name: CMPK1

metaR PAPStg
fast: false
product: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: true
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110026#
name: 3'-Phosphoadenylyl sufate Golgi transport
type: Reaction

metaR G14T17g
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reactant: MODEL1310110026#
modifier: MODEL1310110026#
fast: false
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110026#
is described by: ECO:0000000

metaR r2353
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110026#
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110026#
reversible: true
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110026#_ce06aa1c_b03f_4958_9189_1f0e4e9f9239
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:27068
name: PPA2
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_b6e29af9_3393_4843_a5ea_e5d48c8cbd95
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2954
initial amount: NaN
type: Species
is: O43708
initial concentration: NaN
name: GSTZ1
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_cce43836_d186_475c_8c6a_a4ffb233ef19
is encoded by: hsa:8612
constant: false
boundary condition: true
is: SBO:0000252
name: PPAP2C
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is: E9PAY8

metaM ksi pre24 g
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB00175
type: Species
is: C00130
boundary condition: false
notes: FORMULA: C191H306N13O158S7X CHARGE: -8
initial concentration: 1.0
has only substance units: false
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 24

metaR CYTD
modifier: MODEL1310110026#
name: cytidine deaminase
notes: GENE_ASSOCIATION: (978.1) or (57379.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.5 Confidence Level: 2 AUTHORS: PMID:14744791,PMID:15087440,PMID:7923172,PMID:8001985,PMID:8422236 NOTES:
reversible: false
product: MODEL1310110026#
fast: false
kinetic law: MODEL1310110026#
is: SBO:0000176
type: Reaction
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/3.5.4.5
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_ad645e66_75a0_49e0_8a08_8d05ac6f521d
is encoded by: hsa:64087
type: Species
is: Q9HCC0
constant: false
boundary condition: true
initial amount: NaN
name: MCCC2
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaM pydxn e
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C8H11NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00268 EHMN_ABBREVIATION: C00314
has only substance units: false
is: C00314
name: Pyridoxine
initial concentration: 1.0
constant: false
is: HMDB00239
boundary condition: false
is: CHEBI:16709

metaR OAGD3te
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
name: oagd3 hs transport
kinetic law: MODEL1310110026#
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_bd5d4a74_f388_4810_b614_e907deaec87b
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:29929
name: ALG6
has only substance units: false
constant: false
initial concentration: NaN
is: Q9Y672
type: Species

metaM HC01412 m
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273
is: CHEBI:61405
type: Species
name: trans-tetradec-2-enoyl-CoA(4-)
is: SBO:0000247
boundary condition: false

metaR EX gluala LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5-L-Glutamyl-L-alanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_3d678af6_2bc0_4ef3_b951_d43f52e1337c
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: Q86YU0
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:766
boundary condition: true
name: CA7

metaR CBASPte
is: SBO:0000185
fast: false
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
type: Reaction
name: Transport of N-carbamoyl-L-aspartate
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110026#
reversible: true
is described by: ECO:0000134

metaM ptdca c
is: http://identifiers.org/pubchem.compound/22169126
constant: false
name: pentadecanoate
boundary condition: false
has only substance units: false
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB00826
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_25c56423_266c_46ef_9438_4c9971831158
name: NPR2
is encoded by: hsa:4882
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR r0556
type: Reaction
fast: false
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.19.1
modifier: MODEL1310110026#
is: SBO:0000176
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
product: MODEL1310110026#
reactant: MODEL1310110026#
reversible: true

metaR r0443
kinetic law: MODEL1310110026#
reversible: false
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
type: Reaction
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.1.1.42
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110026#
fast: false
product: MODEL1310110026#
is: SBO:0000176

metaR NACHEX21ly
product: MODEL1310110026#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
reversible: false
reactant: MODEL1310110026#
fast: false
modifier: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_09563ada_1698_4aca_9ef5_bad16423ef86
constant: false
initial amount: NaN
initial concentration: NaN
name: PGM2
is: SBO:0000252
is: Q96G03
is encoded by: hsa:55276
has only substance units: false
type: Species
boundary condition: true

metaR C226COAtx
is described by: ECO:0000000
name: fatty acid intracellular transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
type: Reaction
product: MODEL1310110026#
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110026#_ed9bf761_d186_4c3c_8699_3cd2952aa155
name: ALDH7A1
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:501
initial amount: NaN
boundary condition: true
is: E7EPT3
initial concentration: NaN
has only substance units: false

metaR EX lgnc LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: lignoceric acid exchange
type: Reaction

metaR HEXCt
type: Reaction
name: fatty acid transport via diffusion
reactant: MODEL1310110026#
product: MODEL1310110026#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110026#
reversible: true
fast: false
is described by: ECO:0000000

metaR 1PPDCRp
fast: false
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110026#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:MM
name: delta1-piperideine-2-carboxylate reductase, perixosomal
kinetic law: MODEL1310110026#
is: SBO:0000176
product: MODEL1310110026#

metaR SFCYSe
name: Exit of sulfocysteine into extra-cellular space
fast: false
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 2621485 NOTES:sulfocysteine is exfreted in urine
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
is described by: ECO:0000134

metaR C121CPT1
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecenoylcarnitine
type: Reaction

metaR LTC4CP
is: SBO:0000176
fast: false
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
type: Reaction
reversible: true
name: Leukotriene C4 carboxypeptidase
product: MODEL1310110026#
is described by: ECO:0000000
reactant: MODEL1310110026#

metaM 5aop m
name: 5-Amino-4-oxopentanoate
is: CHEBI:17549
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB01149
constant: false
initial concentration: 1.0
has only substance units: false
is: C00430
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110026#_3f8faeee_5ebe_4926_9046_a0a062e9d0bf
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:50808
is: E7ET30
is: SBO:0000252
boundary condition: true
type: Species
name: AK3

metaR GTHRDt
product: MODEL1310110026#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110026#
fast: false
name: Glutathione transport into mitochondria
is: SBO:0000185
kinetic law: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_aec4b1cc_cd7d_4827_8a3f_d1a1e58c6712
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:8706
is: B3KTQ4
constant: false
is: SBO:0000252
boundary condition: true
name: B3GALNT1

http://identifiers.org/biomodels.db/MODEL1310110026#_669fee4e_8a12_40ec_9d97_1d7c91b8102d
initial amount: NaN
is encoded by: hsa:6487
type: Species
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
name: ST3GAL3
initial concentration: NaN

metaM pro D c
is: HMDB03411
boundary condition: false
name: D-proline
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:16313
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1

metaM fe3 e
is: HMDB12943
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: Fe CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC01847
initial amount: NaN
constant: false
name: Fe3+
is: SBO:0000247
is: CHEBI:29034
boundary condition: false

metaM chol n
is: CHEBI:15354
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB00097
name: choline
type: Species
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114

http://identifiers.org/biomodels.db/MODEL1310110026#_0cd29f2a_3887_41b5_b0e2_ef8b6c6f8ce7
initial amount: NaN
is: Q86TM7
is: SBO:0000252
name: DPM3
has only substance units: false
is encoded by: hsa:54344
constant: false
initial concentration: NaN
type: Species
boundary condition: true

metaM bilirub r
is: SBO:0000247
name: bilirubin(2-)
type: Species
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB00054
is: CHEBI:57977
boundary condition: false
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486

http://identifiers.org/biomodels.db/MODEL1310110026#_f6c03a61_cb4b_44bb_86e6_f152dad05a5d
boundary condition: true
initial concentration: NaN
is: P52824
constant: false
has only substance units: false
is encoded by: hsa:1609
is: SBO:0000252
name: DGKQ
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_4c371c72_db40_49a2_a857_197b8209245a
has only substance units: false
is: P00439
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5053
is: SBO:0000252
name: PAH
type: Species
constant: false

metaR r0156
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.40
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
reversible: false
product: MODEL1310110026#
fast: false
is: SBO:0000176
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
type: Reaction
is described by: ECO:0000000

metaM dha e
has only substance units: false
is: HMDB01882
initial concentration: 1.0
initial amount: NaN
name: glycerone
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
type: Species
is: CHEBI:16016

metaR LEUKTRB4t
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110026#
name: leukotriene B4 transport
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_c4b3b486_3590_43ce_903a_04a2dab16e2e
boundary condition: true
name: _22305_2_c
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:22305
is: SBO:0000252
initial concentration: NaN
type: Species

metaR H2MTer U
reversible: false
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (55650.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15623507 NOTES:NCD
name: H2 mannosyltransferase, endoplasmic reticulum
fast: false
product: MODEL1310110026#
is: SBO:0000176

metaR BTNPLm
reversible: false
is version of: http://identifiers.org/ec-code/6.3.4.10
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
is: SBO:0000176
type: Reaction
product: MODEL1310110026#
name: holocarboxylase synthestase (biotin protein ligase), mitochondrial
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
fast: false
modifier: MODEL1310110026#

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_14bcbf52_6182_4ef3_9c83_bd3945e46390
initial amount: NaN
name: TXNRD1
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:7296
boundary condition: true
has only substance units: false

metaR H2Oter
type: Reaction
name: H2O endoplasmic reticulum transport
product: MODEL1310110026#
is: SBO:0000185
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reversible: true
fast: false
kinetic law: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_a836f9c0_1ba5_494a_bf74_6d5f3f757336
is encoded by: hsa:8394
is: SBO:0000252
initial concentration: NaN
name: PIP5K1A
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: Q99755
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110026#_ec26e570_927b_4a9c_8a6c_ff781f1beef1
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:50484
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
is: Q7LG56
name: RRM2B

metaM ptdca e
is: http://identifiers.org/pubchem.compound/22169126
name: pentadecanoate
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)
is: HMDB00826
initial amount: NaN
constant: false

metaM Ser Thr g
is: CHEBI:58336
is: HMDB00645
name: protein-linked serine or threonine residue (O-glycosylation site)
has only substance units: false
is: SBO:0000247
notes: FORMULA: XH CHARGE: 0
initial amount: NaN
boundary condition: false
type: Species
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110026#_5d2ca74d_0e12_43d6_848c_d9b6fc289572
is: P00915
constant: false
boundary condition: true
initial amount: NaN
name: CA1
initial concentration: NaN
is encoded by: hsa:759
is: SBO:0000252
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_9b3dfaf7_1710_4411_96a5_156a01c5469b
has only substance units: false
is encoded by: hsa:4538
initial amount: NaN
name: ND4
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is: P03905

metaR 4MOPte
reactant: MODEL1310110026#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110026#
name: Transport of 4-methyl-2-oxopentanoate
type: Reaction
kinetic law: MODEL1310110026#

metaR r0441
is described by: ECO:0000000
is: SBO:0000176
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
modifier: MODEL1310110026#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.40
reactant: MODEL1310110026#
type: Reaction
product: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_1f4b3be5_397a_4871_90e5_bd322f576223
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:9091
is: Q9BRB3
name: PIGQ
is: SBO:0000252

metaR RETFAt
type: Reaction
fast: false
name: fatty acid retinol efflux
reactant: MODEL1310110026#
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reversible: false
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_4f2d2210_ade4_481d_b963_09505a47ba57
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5232
name: PGK2
initial concentration: NaN
is: P07205
has only substance units: false
constant: false
initial amount: NaN

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

metaR RE2666G
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.274
reversible: false
kinetic law: MODEL1310110026#
name: RE2666
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (9331.1) SUBSYSTEM: Glycosphingolipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7930586 NOTES:
modifier: MODEL1310110026#
product: MODEL1310110026#
type: Reaction
reactant: MODEL1310110026#

metaR SO4tl
name: Sulfate transport (lysosome)
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
type: Reaction
is described by: ECO:0000269
fast: false
reactant: MODEL1310110026#
product: MODEL1310110026#
kinetic law: MODEL1310110026#

metaR SUCCCROT
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of succinyl carnitine
type: Reaction

metaR SFCYSc
reactant: MODEL1310110026#
is: SBO:0000176
product: MODEL1310110026#
is described by: ECO:0000134
fast: false
reversible: true
kinetic law: MODEL1310110026#
name: Formation of sulfocysteine
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID: 2621485 NOTES:non-enzymatic reaction. Sulfocysteine is excreted in the urine.One proton added for elemental balancing.

metaR r0157
type: Reaction
is described by: ECO:0000000
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
is version of: http://identifiers.org/ec-code/6.3.4.2
product: MODEL1310110026#
reactant: MODEL1310110026#
modifier: MODEL1310110026#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110026#
reversible: false
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:

metaR COQ7m
product: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: false
fast: false
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
name: Ubiquinone biosynthesis COQ7
modifier: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (10229.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_1.14.13.- IT

metaR DCK2n
is: SBO:0000176
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.7.1.74
type: Reaction
is described by: ECO:0000269
reversible: true
name: Deoxycytidine kinase, nuclear (UTP)
fast: false
modifier: MODEL1310110026#
product: MODEL1310110026#
kinetic law: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_85a80c4d_2992_43a9_8dbf_c4151eeeb729
type: Species
is: Q02846
name: GUCY2D
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3000
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false

metaM fe3 c
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: Fe CHARGE: 3
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: Fe3+
type: Species
is: HMDB12943

metaR FACOAL246 1
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000
reactant: MODEL1310110026#
fast: false
modifier: MODEL1310110026#
is: SBO:0000176
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110026#
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110026#_238e4070_b381_44f3_95e3_f011c161845a
initial amount: NaN
has only substance units: false
type: Species
name: ALG2
is: Q9H553
boundary condition: true
is encoded by: hsa:85365
initial concentration: NaN
constant: false
is: SBO:0000252

metaM pro D e
initial concentration: 1.0
type: Species
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
boundary condition: false
name: D-proline
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:16313
is: SBO:0000247
is: HMDB03411

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

metaM utp n
type: Species
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: CHEBI:46398
constant: false
initial amount: NaN
boundary condition: false
name: UTP(4-)
is: HMDB00285
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaM cs e deg2 l
boundary condition: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 2
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:57455
initial concentration: 1.0
constant: false
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
is: HMDB01354
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_732b6180_d92f_45be_8291_fc8cc0e2a02d
constant: false
initial amount: NaN
name: HK1
is encoded by: hsa:3098
is: P78542
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN

metaM hdca r
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: Hexadecanoate (n-C16:0)
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: CHEBI:7896
initial concentration: 1.0
type: Species
boundary condition: false
is: C00249
is: HMDB00220
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_2c4aac4c_f305_469d_8d76_87af481b9c61
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4704
name: NDUFA9
is: Q16795

metaR AICART
fast: false
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
reactant: MODEL1310110026#
product: MODEL1310110026#
is: SBO:0000176
name: phosphoribosylaminoimidazolecarboxamide formyltransferase
is version of: http://identifiers.org/ec-code/2.1.2.3
reversible: true
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#

metaR UAGALDP
name: UDP-N-acetylgalactosamine diphosphorylase
kinetic law: MODEL1310110026#
is described by: ECO:0000000
reversible: false
type: Reaction
reactant: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110026#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110026#_723f5169_a4ac_4530_a816_3d18e6e7c682
initial amount: NaN
name: COX4I1
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
is: P13073
is encoded by: hsa:1327

metaR DOLPMT2 Uer
reversible: false
type: Reaction
reactant: MODEL1310110026#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110026#
is described by: ECO:0000000
product: MODEL1310110026#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110026#_d30b83bd_af10_4e4e_b4e4_afaac33a13b4
name: ALDH3B2
constant: false
is: P48448
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:222
is: SBO:0000252

metaR r1832
is described by: ECO:0000000
reactant: MODEL1310110026#
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
kinetic law: MODEL1310110026#
reversible: false
is: SBO:0000185
name: Y+LAT2 Utilized transport
product: MODEL1310110026#

metaM leuktrA4 r
is: SBO:0000247
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
initial concentration: 1.0
is: HMDB01337
name: leukotriene A4(1-)
initial amount: NaN
type: Species
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:57463

http://identifiers.org/biomodels.db/MODEL1310110026#_540b59fa_22cd_4200_9847_258b174ec602
constant: false
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:29926
initial amount: NaN
name: GMPPA
is: SBO:0000252

metaM ach c
initial concentration: 1.0
type: Species
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
initial amount: NaN
is: SBO:0000247
is: HMDB00895
constant: false
is: CHEBI:15355
name: acetylcholine
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_fe134f92_5c09_4948_afbd_150e5c7172ce
initial amount: NaN
type: Species
name: PPA2
boundary condition: true
constant: false
initial concentration: NaN
is: F8WDN9
is: SBO:0000252
is encoded by: hsa:27068
has only substance units: false

metaM Ser Thr l
initial concentration: 1.0
is: CHEBI:58190
constant: false
type: Species
notes: FORMULA: XH CHARGE: 0
boundary condition: false
initial amount: NaN
is: HMDB00224
has only substance units: false
name: protein-linked serine or threonine residue (O-glycosylation site)
is: SBO:0000247

metaM CE5236 n
is: HMDB03952
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
initial amount: NaN
is: CHEBI:28002
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: O2'-4a-cyclic-tetrahydrobiopterin
type: Species
constant: false
is: SBO:0000247

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_92eb71bf_4c5e_423f_a579_6c1c710f30ac
is encoded by: hsa:221823
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true
name: PRPS1L1
initial concentration: NaN

metaR FACOAL240
type: Reaction
name: fatty-acid--CoA ligase
is: SBO:0000176
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is described by: ECO:0000269
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
reversible: true

metaR OAGD3tg
is described by: ECO:0000000
product: MODEL1310110026#
type: Reaction
reactant: MODEL1310110026#
is: SBO:0000185
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
fast: false
reversible: true
name: oagd3 hs intracellular transport

metaR r0558
reversible: true
is described by: ECO:0000000
is: SBO:0000176
fast: false
reactant: MODEL1310110026#
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.5.1.3
kinetic law: MODEL1310110026#
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
type: Reaction
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110026#_c416f1af_a554_4d44_981d_dffe855d5e16
is: SBO:0000252
is encoded by: hsa:80235
is: Q86VD9
constant: false
boundary condition: true
type: Species
has only substance units: false
name: PIGZ
initial concentration: NaN
initial amount: NaN

metaM xoldioloneh c
constant: false
boundary condition: false
initial amount: NaN
name: 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-18,20-25,29-30H,6-15H2,1-5H3/t17-,18+,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01462 EHMN_ABBREVIATION: C05453
is: CHEBI:2288
has only substance units: false
is: HMDB06887
type: Species
initial concentration: 1.0
is: SBO:0000247

metaR GALASE11ly
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
reactant: MODEL1310110026#
type: Reaction
product: MODEL1310110026#
name: beta-galactosidase, lysosomal
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
kinetic law: MODEL1310110026#
is: SBO:0000176
fast: false

metaR RE3301C
reactant: MODEL1310110026#
reversible: true
name: RE3301
fast: false
product: MODEL1310110026#
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:11182251 NOTES:
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.4
is described by: ECO:0000000
kinetic law: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_b8a179b8_4c16_44bd_82a6_808bb577d9c5
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
is: Q96DU7
name: ITPKC
is encoded by: hsa:80271
type: Species
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_2710fb3a_81f0_4715_b63c_02e9de186948
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:55825
name: PECR
is: Q9BY49
boundary condition: true
constant: false
initial amount: NaN

metaM oxa c
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:30623
boundary condition: false
type: Species
name: oxalate(2-)
has only substance units: false
constant: false
is: HMDB02329

metaR ABTti
is: SBO:0000185
reactant: MODEL1310110026#
type: Reaction
reversible: false
is described by: ECO:0000000
product: MODEL1310110026#
kinetic law: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
name: L-arabinitol transport via passive diffusion

http://identifiers.org/biomodels.db/MODEL1310110026#_2ed556fc_9a91_4097_8a3c_f9a2d5b185de
name: GGT3P
is encoded by: hsa:2679
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_636fb7ff_8d7d_4f01_ab18_67e26b1b37ae
initial amount: NaN
type: Species
is: SBO:0000252
name: _BC005314_1_x
constant: false
is encoded by: hsa:BC005314
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR r0559
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.5.1.3
fast: false
reactant: MODEL1310110026#
is described by: ECO:0000000
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
reversible: true
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
is: SBO:0000176
product: MODEL1310110026#
type: Reaction

metaR FACOAL241
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110026#
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
fast: false
is described by: ECO:0000000
modifier: MODEL1310110026#
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_a435d30e_1238_4ba1_bb91_f4306b3c8421
is: SBO:0000252
is encoded by: hsa:39
constant: false
boundary condition: true
has only substance units: false
is: Q9BWD1
type: Species
initial amount: NaN
initial concentration: NaN
name: ACAT2

metaR EX acmana LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-acetyl-D-mannosamine
type: Reaction

metaM cs b deg3 l
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 3
is: CHEBI:21338
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB02704
notes: FORMULA: C37H55NO38S2 CHARGE: -4

metaM apoC Lys btn m
notes: FORMULA: C16H27N4O3SX CHARGE: 0
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
boundary condition: false
is: HMDB03134
is: C05552
has only substance units: false
is: http://identifiers.org/pubchem.compound/7886

http://identifiers.org/biomodels.db/MODEL1310110026#_a18fc335_c2ad_4f33_ab69_9c8381b76226
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:122481
has only substance units: false
constant: false
is: Q96M32
name: AK7
is: SBO:0000252
type: Species

metaR EX c5dc
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glutaryl carnitine
type: Reaction

metaM ach e
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
is: HMDB00895
constant: false
is: CHEBI:15355
name: acetylcholine
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110026#_c80452a8_f76f_42d9_8cfb_8b28ae7ec7ee
initial concentration: NaN
is: SBO:0000252
is: B2RB13
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
name: ACSL6
is encoded by: hsa:23305

metaM ksii core2 pre9 g
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 9
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C75H120N6O59S2X CHARGE: -3
has only substance units: false
is: CHEBI:28067
is: SBO:0000247
type: Species

metaR EX cspg e LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan exchange
type: Reaction

metaM 4mop m
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:17865
is: SBO:0000247
is: HMDB00695
name: 4-methyl-2-oxopentanoate
initial amount: NaN
constant: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
boundary condition: false

metaR r1792
is described by: ECO:0000000
reversible: false
type: Reaction
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reactant: MODEL1310110026#
product: MODEL1310110026#
modifier: MODEL1310110026#
fast: false
is: SBO:0000185

metaM h2o2 n
constant: false
has only substance units: false
name: hydrogen peroxide
initial concentration: 1.0
is: CHEBI:16240
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: HMDB03125
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247

metaM hdca e
is: SBO:0000247
is: C00249
constant: false
is: CHEBI:0
boundary condition: false
notes: FORMULA: C16H31O2 CHARGE: -1
initial amount: NaN
is: HMDB00220
initial concentration: 1.0
name: Hexadecanoate (n-C16:0)
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_02422e12_3902_4dab_aa5e_0eee9d76936a
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:NM 013421
name: _NM_013421_1_e
constant: false

metaR AKR1D
is version of: http://identifiers.org/ec-code/1.3.1.3
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
is: SBO:0000176
reversible: false
is described by: ECO:0000269
type: Reaction
product: MODEL1310110026#
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
fast: false

http://identifiers.org/biomodels.db/MODEL1310110026#_bbda1ee9_9f36_4a04_ad12_634bada2a6ea
boundary condition: true
is encoded by: hsa:79646
initial amount: NaN
has only substance units: false
name: PANK3
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
is: Q9H999

http://identifiers.org/biomodels.db/MODEL1310110026#_0a9d0ff5_0e59_4ba5_a37d_bb9a6b8517f0
is: O95167
is encoded by: hsa:4696
type: Species
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: NDUFA3

http://identifiers.org/biomodels.db/MODEL1310110026#_4eabf0ab_f5cb_4b94_8c07_c1af275aa5e0
name: NDUFAB1
initial amount: NaN
is encoded by: hsa:4706
type: Species
initial concentration: NaN
is: O14561
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true

metaM dcmp c
is: HMDB01202
initial amount: NaN
name: dCMP
is: CHEBI:57566
constant: false
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
is: C00239
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_e2d6062c_9540_45e5_87ee_87a85bd472aa
is: O75715
constant: false
initial concentration: NaN
initial amount: NaN
name: GPX5
is encoded by: hsa:2880
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_d5edc875_8560_4837_aa87_92c4a75935fb
boundary condition: true
name: _AA854479_1_m
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AA854479
constant: false
initial amount: NaN
type: Species
has only substance units: false

metaM slfcys e
notes: FORMULA: C3H8NO5S2 CHARGE: -1
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: S-Sulfo-L-cysteine
is: HMDB00731
constant: false
boundary condition: false
is: SBO:0000247
type: Species
is: C05824

metaR FMNAT
reactant: MODEL1310110026#
modifier: MODEL1310110026#
is described by: ECO:0000134
fast: false
name: FMN adenylyltransferase
type: Reaction
kinetic law: MODEL1310110026#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.7.2
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
product: MODEL1310110026#
is: SBO:0000176

metaR M16NTg
modifier: MODEL1310110026#
product: MODEL1310110026#
reversible: false
name: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.143
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110026#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4247.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.143 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
reactant: MODEL1310110026#

metaR MI134PP
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.1.3.57
reactant: MODEL1310110026#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (3628.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.61 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:8390685 NOTES:NCD
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: false
name: inositol-1,3,4-trisphosphate 1-phosphatase
is described by: ECO:0000269
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110026#_5aeeba54_8614_4d3f_ac12_6a1868a0c3b5
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
name: PKLR
type: Species
is encoded by: hsa:5313
is: SBO:0000252

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

metaR RETNt
name: retinoic acid transport
kinetic law: MODEL1310110026#
product: MODEL1310110026#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
reversible: true

metaM h2o2 m
is: HMDB03125
boundary condition: false
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:16240
is: C00027
name: Hydrogen peroxide
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_5cb11a1f_2954_405a_8574_80566d555d4b
name: SLC27A2
has only substance units: false
type: Species
is encoded by: hsa:11001
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
is: O14975

metaR DESAT22 2p
name: fatty acyl-CoA desaturase (n-C22:5CoA -> n-C22:6CoA)
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
fast: false
reversible: false
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_f0867b26_d051_48bf_a93b_8ce7bbf66752
constant: false
initial amount: NaN
is encoded by: hsa:1629
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
name: DBT
is: P11182
type: Species

metaR RE3566C
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reversible: true
product: MODEL1310110026#
is described by: ECO:0000000
name: RE3566
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110026#
fast: false

metaM tre e
constant: false
initial amount: NaN
name: Trehalose
has only substance units: false
is: C01083
is: CHEBI:16551
is: HMDB00975
is: SBO:0000247
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00658 EHMN_ABBREVIATION: C01083
initial concentration: 1.0
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110026#_c1111f1e_438a_41fd_a200_f3cff8f20b07
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: B2RDU6
is encoded by: hsa:4598
type: Species
is: SBO:0000252
name: MVK
constant: false

metaM lnlncgcoa m
constant: false
is: SBO:0000247
is: CHEBI:57363
name: gamma-linolenoyl-CoA(4-)
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB06368

metaM pi x
initial amount: NaN
constant: false
is: SBO:0000247
name: hydrogenphosphate
initial concentration: 1.0
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
type: Species
is: CHEBI:43474
boundary condition: false
is: HMDB00973
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_d43cfa7b_e20c_4df3_8404_e45af77789bf
initial amount: NaN
name: LDHC
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:3948
is: SBO:0000252
constant: false

metaM gm3 hs g
is: CHEBI:60065
constant: false
notes: FORMULA: C41H72N2O20FULLRCO CHARGE: -1 EHMN_ABBREVIATION: C04730
name: alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide(1-)
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false

metaR S6T6g
is described by: ECO:0000000
reversible: false
type: Reaction
kinetic law: MODEL1310110026#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110026#
product: MODEL1310110026#
fast: false
modifier: MODEL1310110026#
is: SBO:0000176
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

metaR C226CPT1
is: SBO:0000176
reactant: MODEL1310110026#
modifier: MODEL1310110026#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
product: MODEL1310110026#
kinetic law: MODEL1310110026#
name: carnitine C22:6 transferase

metaM acetone e
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15347
constant: false
name: acetone
has only substance units: false
boundary condition: false
is: HMDB01659
is: SBO:0000247
type: Species
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207

metaM adn c
initial concentration: 1.0
constant: false
is: HMDB00050
is: SBO:0000247
is: CHEBI:16335
has only substance units: false
initial amount: NaN
is: C00212
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
boundary condition: false
type: Species
name: Adenosine

http://identifiers.org/biomodels.db/MODEL1310110026#_8e12fb0d_e2d6_486e_8207_e0cdad064bb6
name: PIK3C3
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: Q8NEB9
initial concentration: NaN
is encoded by: hsa:5289
boundary condition: true
is: SBO:0000252

metaR CYTK14
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110026#
name: cytidylate kinase (dCMP,UTP)
product: MODEL1310110026#
is described by: ECO:0000269
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction

metaM Rtotal3coa c
constant: false
notes: FORMULA: CO2FULLR3C21H31N7O15P3S CHARGE: -4
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB01448
is: CHEBI:16189
initial concentration: 1.0
boundary condition: false
name: R total 3 Coenzyme A

http://identifiers.org/biomodels.db/MODEL1310110026#_7f84ad09_a716_40d9_8f7d_cc4e021a4b95
is: SBO:0000252
is encoded by: hsa:6547
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: SLC8A3
boundary condition: true
constant: false
is: Q96QG2
type: Species

metaM slfcys c
notes: FORMULA: C3H8NO5S2 CHARGE: -1
is: C05824
has only substance units: false
initial amount: NaN
name: S-Sulfo-L-cysteine
initial concentration: 1.0
boundary condition: false
is: HMDB00731
type: Species
constant: false
is: SBO:0000247

metaM ksi pre16 g
is: SBO:0000247
notes: FORMULA: C157H253N11O124S4X CHARGE: -5
is: CHEBI:58053
initial concentration: 1.0
is: C00130
boundary condition: false
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 16
type: Species
constant: false
initial amount: NaN
is: HMDB00175

http://identifiers.org/biomodels.db/MODEL1310110026#_8f3414c9_f561_405b_b669_8c8aa9ae9d17
boundary condition: true
has only substance units: false
constant: false
has part: P43034
name: PAFAH1B1:PAFAH1B2:PAFAH1B3
is: SBO:0000297
is encoded by: hsa:5048
initial amount: NaN
initial concentration: NaN
type: Species

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

metaR MANt1r
product: MODEL1310110026#
reactant: MODEL1310110026#
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110026#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6513.1) or (6515.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:NCD
reversible: true
name: mannose transport (uniport)
modifier: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_5e00a0c5_be4d_45a0_881d_771a517b712a
boundary condition: true
is encoded by: hsa:132789
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is: Q8TDQ7
name: GNPDA2
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110026#_ce6be6c4_0015_4ac6_b6de_daaf09e482c8
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
name: ST3GAL3
is encoded by: hsa:6487
initial amount: NaN

metaR EX for LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Formate exchange
type: Reaction

metaR r1527
modifier: MODEL1310110026#
is: SBO:0000185
product: MODEL1310110026#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.1
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
reactant: MODEL1310110026#
type: Reaction
reversible: false
fast: false
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
kinetic law: MODEL1310110026#

metaR C226CPT2
fast: false
is described by: ECO:0000000
product: MODEL1310110026#
kinetic law: MODEL1310110026#
type: Reaction
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:TDV
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
is: SBO:0000176
modifier: MODEL1310110026#
name: C226 transport into the mitochondria

metaR RE1521M
is: SBO:0000176
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
product: MODEL1310110026#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110026#
name: RE1521
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is described by: ECO:0000000

metaR DNDPt33m
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110026#
name: dGDP transport via dUDP antiport
reversible: false
type: Reaction
is: SBO:0000185
modifier: MODEL1310110026#
fast: false
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000269

metaM 1p3h5c m
initial concentration: 1.0
is: CHEBI:6151
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
constant: false
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
is: HMDB01369
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281

http://identifiers.org/biomodels.db/MODEL1310110026#_3418caba_dc69_4cd6_9e60_80a357786e48
constant: false
is: SBO:0000297
type: Species
has part: B4DER4
boundary condition: true
is encoded by: hsa:5291
initial amount: NaN
is encoded by: hsa:5295
name: PIK3CB:PIK3R1
initial concentration: NaN
has only substance units: false
has part: B3KT19

metaM acmana r
is: SBO:0000247
type: Species
is: HMDB01129
boundary condition: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
is: CHEBI:17122
initial amount: NaN
constant: false
initial concentration: 1.0
name: N-acetyl-D-mannosamine
has only substance units: false

metaM dgchol c
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:36252
initial concentration: 1.0
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
is: HMDB00637
name: glycochenodeoxycholate
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_922069cf_9831_425f_bedf_59ba76e41a8c
boundary condition: true
constant: false
is encoded by: hsa:FLJ44968
name: _FLJ44968_1_m
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_d3855acd_9b0f_45e7_ae68_956565b1efb2
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:374907
is: SBO:0000252
is: Q7Z7M8
name: B3GNT8
initial amount: NaN
constant: false

metaR r2202
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000000
fast: false
type: Reaction
modifier: MODEL1310110026#
product: MODEL1310110026#
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5

metaR CYTK12
reactant: MODEL1310110026#
reversible: true
kinetic law: MODEL1310110026#
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110026#
name: cytidylate kinase (dCMP,dCTP)
is: SBO:0000176
is described by: ECO:0000269
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM acetone c
constant: false
name: acetone
is: SBO:0000247
is: CHEBI:15347
is: HMDB01659
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110026#_da7484f3_2e2c_406f_96fd_5bb8733abb0a
initial concentration: NaN
has only substance units: false
is: Q9H6R3
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:79611
initial amount: NaN
name: ACSS3
boundary condition: true

metaM bilirub e
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
name: bilirubin(2-)
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:57977
is: HMDB00054
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110026#_6b14d3d3_1a5e_4c3c_9f13_8767ba773ac4
initial amount: NaN
name: FPGT
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:8790
is: O14772

metaM chol c
initial concentration: 1.0
type: Species
is: HMDB00097
is: C00114
has only substance units: false
is: CHEBI:15354
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
name: Choline

http://identifiers.org/biomodels.db/MODEL1310110026#_eef378b5_47ab_4654_b15d_f3b9feee37c2
name: HSD3B2
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:3284
initial concentration: NaN
boundary condition: true
is: P26439
initial amount: NaN
constant: false

metaM g6p r
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
initial amount: NaN
boundary condition: false
is: HMDB01401
type: Species
is: CHEBI:61548
name: D-Glucose 6-phosphate
is: C00092

metaR r0885
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110026#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: true
is version of: http://identifiers.org/ec-code/1.3.1.38
is described by: ECO:0000000
product: MODEL1310110026#

metaR r2201
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
product: MODEL1310110026#
is: SBO:0000185
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
type: Reaction
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
modifier: MODEL1310110026#

metaM eicostet c
initial amount: NaN
type: Species
notes: FORMULA: C20H31O2 CHARGE: -1
initial concentration: 1.0
constant: false
is: HMDB02177
has only substance units: false
is: CHEBI:36033
boundary condition: false
is: SBO:0000247
name: eicosatetranoic acid

http://identifiers.org/biomodels.db/MODEL1310110026#_3db446ce_eee3_4287_9996_f8a090ab20e1
is: SBO:0000252
name: ADSL
constant: false
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:158
has only substance units: false

metaR CYTK13
kinetic law: MODEL1310110026#
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP,dATP)
reversible: true
fast: false
is described by: ECO:0000269
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110026#
is: SBO:0000176
type: Reaction

metaM 10fthf6glu e
initial concentration: 1.0
boundary condition: false
name: 10-formyltetrahydrofolate-[Glu](6)
initial amount: NaN
type: Species
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1
has only substance units: false
is: SBO:0000247
is: CHEBI:16236
constant: false
is: HMDB00108

http://identifiers.org/biomodels.db/MODEL1310110026#_f266b4fb_c27d_4e1b_a8dc_72e9b251f8eb
name: SLC5A7
is: Q9GZV3
is encoded by: hsa:60482
is: SBO:0000252
type: Species
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaM lnlncgcoa r
name: gamma-linolenoyl-CoA(4-)
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB06368
is: CHEBI:57363
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_6db582cb_56c6_4d06_a1c3_d3cef1aded47
is encoded by: hsa:1109
initial amount: NaN
initial concentration: NaN
is: P17516
name: AKR1C4
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
constant: false

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

metaR FAOXC4C2m
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C4-->C2)m
type: Reaction

metaM dgchol e
is: SBO:0000247
name: glycochenodeoxycholate
initial amount: NaN
type: Species
is: CHEBI:36252
has only substance units: false
initial concentration: 1.0
is: HMDB00637
constant: false
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
boundary condition: false

metaM 4mop e
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
is: HMDB00695
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
name: 4-methyl-2-oxopentanoate
initial amount: NaN
is: CHEBI:17865
boundary condition: false

metaR THFtm
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110026#
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
reversible: true
kinetic law: MODEL1310110026#
product: MODEL1310110026#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD

metaR ABO1g
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.37
kinetic law: MODEL1310110026#
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110026#
fast: false
product: MODEL1310110026#
type: Reaction
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
reactant: MODEL1310110026#
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)

metaR r2200
reactant: MODEL1310110026#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110026#
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
is: SBO:0000185
kinetic law: MODEL1310110026#

metaR r1837
fast: false
kinetic law: MODEL1310110026#
is described by: ECO:0000000
product: MODEL1310110026#
is: SBO:0000185
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110026#
type: Reaction
modifier: MODEL1310110026#
reversible: false

metaR CYTK10
name: cytidylate kinase (CMP,dGTP)
product: MODEL1310110026#
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
fast: false
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
type: Reaction

metaR r0149
is version of: http://identifiers.org/ec-code/1.14.13.39
modifier: MODEL1310110026#
product: MODEL1310110026#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110026#
reversible: true
reactant: MODEL1310110026#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5

metaM bilirub c
initial amount: NaN
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
is: HMDB00054
name: bilirubin(2-)
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:57977

metaM chol e
constant: false
is: HMDB00097
initial concentration: 1.0
is: SBO:0000247
is: C00114
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
name: Choline
is: CHEBI:15354
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_93a6aeed_9fda_45cd_b847_4561864fe790
type: Species
has only substance units: false
is: SBO:0000252
name: B4GALT5
initial amount: NaN
constant: false
boundary condition: true
is: O43286
initial concentration: NaN
is encoded by: hsa:9334

http://identifiers.org/biomodels.db/MODEL1310110026#_25f270c0_e438_4e64_bf6c_ce9e9f270cb4
initial concentration: NaN
is: P23677
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:3706
initial amount: NaN
name: ITPKA

http://identifiers.org/biomodels.db/MODEL1310110026#_8d2c8f12_db4f_492b_85cc_4518ed07f40e
is encoded by: hsa:2348
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
name: FOLR1
is: SBO:0000252

metaR DRIBt
is described by: ECO:0000000
reactant: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
reversible: true
is: SBO:0000185
name: deoxyribose transport via diffusion
fast: false

metaR CYTK11
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110026#
name: cytidylate kinase (dCMP,dGTP)
reversible: true
fast: false
modifier: MODEL1310110026#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is: SBO:0000176

metaM eicostet e
name: eicosatetranoic acid
constant: false
is: HMDB02177
notes: FORMULA: C20H31O2 CHARGE: -1
initial concentration: 1.0
is: CHEBI:36033
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species

metaR RE2999M
name: RE2999
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
fast: false
is: SBO:0000176
modifier: MODEL1310110026#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/5.3.3.8
kinetic law: MODEL1310110026#
reversible: true
type: Reaction

metaM hdca l
name: palmitate
is: CHEBI:7896
initial amount: NaN
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
boundary condition: false
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
is: HMDB00220
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110026#_faab6655_d9c2_4112_9320_047690eec1f2
is: Q5JT09
is encoded by: hsa:83549
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
name: UCK1
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_1b2fe725_d9bd_4713_8976_73a671c27ac3
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
name: PSPH
has only substance units: false
type: Species
initial concentration: NaN
is: P78330
is encoded by: hsa:5723

http://identifiers.org/biomodels.db/MODEL1310110026#_6d8addc6_8139_41a8_92ce_823846399774
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:6575
type: Species
name: SLC20A2
is: B2RBR4
initial concentration: NaN
constant: false

metaR r2086
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110026#
is: SBO:0000185
product: MODEL1310110026#
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
fast: false
is described by: ECO:0000000

metaM h2o2 e
has only substance units: false
boundary condition: false
is: HMDB03125
constant: false
initial amount: NaN
name: hydrogen peroxide
is: SBO:0000247
type: Species
is: CHEBI:16240
initial concentration: 1.0
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027

metaM 4mop c
initial concentration: 1.0
is: CHEBI:17865
is: HMDB00695
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
name: 4-methyl-2-oxopentanoate
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_2d95720c_f112_434d_be73_7f3e80c8de85
name: MPST
has only substance units: false
constant: false
is: P25325
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4357
type: Species
initial amount: NaN
initial concentration: NaN

metaM pail34p hs c
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57658
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_0c751427_9d8e_4696_973f_a52e1d629a7f
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
name: COASY
is encoded by: hsa:80347
is: Q13057
type: Species

metaR EX decdicrn
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decadienoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_0a256583_4b7e_40bb_be55_6adf0f1bdd62
is encoded by: hsa:10005
is: O14734
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
constant: false
name: ACOT8

http://identifiers.org/biomodels.db/MODEL1310110026#_b43ae12d_6455_46a6_9c79_7f7690f03e82
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: NDUFA13
is: Q9P0J0
is encoded by: hsa:51079
initial amount: NaN
has only substance units: false

metaR G14T18g
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
modifier: MODEL1310110026#
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
product: MODEL1310110026#
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110026#

metaM c16dc e
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C23H42NO6 CHARGE: -1
name: Hexadecanedioic acid mono-L-carnitine ester
constant: false
initial concentration: 1.0
is: HMDB00712
boundary condition: false

metaR r2085
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
product: MODEL1310110026#
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
type: Reaction
fast: false
reversible: true
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM dag hs r
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:18035
type: Species
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
name: diglyceride
boundary condition: false
initial amount: NaN

metaM ak2lgchol hs e
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317
type: Species
is: C04317
is: http://identifiers.org/pubchem.compound/6975
name: 1-alkyl 2-lysoglycerol 3-phosphocholine
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_c5a7f105_8be3_4d8d_9e26_359fc9a4f268
is: Q02218
initial amount: NaN
type: Species
is encoded by: hsa:4967
has only substance units: false
name: OGDH
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaR FAOXC204
is: SBO:0000176
reactant: MODEL1310110026#
type: Reaction
is described by: ECO:0000269
reversible: false
fast: false
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110026#
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (35.1) or (35.1) or (34.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
name: Beta oxidation of long chain fatty acid

metaM xoltriol c
constant: false
is: HMDB01457
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
is: CHEBI:16496
initial concentration: 1.0
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_550afcd3_dc7f_407b_926c_b135640096dc
is: Q9NRA0
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
name: SPHK2
is encoded by: hsa:56848
is: SBO:0000252
constant: false
has only substance units: false

metaR UMPK6n
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110026#
name: UMP kinase (dCTP),nuclear
reactant: MODEL1310110026#
is described by: ECO:0000269
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.7.4.14

http://identifiers.org/biomodels.db/MODEL1310110026#_ab2768c3_7d24_4907_b649_247c2abf503a
name: HK1
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
is: B3KXY9
is encoded by: hsa:3098
is: SBO:0000252

metaR FAOXC12DCTc
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of dodecanedioyl carnitine into cytosol
type: Reaction

metaM pydx c
is: HMDB01545
initial amount: NaN
is: CHEBI:17310
name: Pyridoxal
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
is: C00250
notes: FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_65b1a258_20e3_4043_aeba_4dfaa92d3bb5
name: FOLR1
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2348
has only substance units: false
initial concentration: NaN
type: Species
constant: false

metaR r0994
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reversible: true
is described by: ECO:0000000
fast: false
name: Facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
type: Reaction
is: SBO:0000185
reactant: MODEL1310110026#

metaR GTHO
type: Reaction
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.8.1.7
is: SBO:0000176
modifier: MODEL1310110026#
is described by: ECO:0000254
fast: false
reversible: false
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
name: glutathione oxidoreductase

metaR INSTt2r
fast: false
reversible: true
kinetic law: MODEL1310110026#
name: inositol transport in via proton symport
reactant: MODEL1310110026#
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110026#
type: Reaction
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:

metaR r2088
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reversible: true
reactant: MODEL1310110026#
product: MODEL1310110026#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110026#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110026#

metaM lnlncacoa c
boundary condition: false
is: HMDB06290
is: CHEBI:51985
has only substance units: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,26-28,32-34,38,49-50H,4,7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE4809
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
name: alpha-Linolenoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110026#_4d49e587_28ba_4220_a71f_1693c2f24d2b
type: Species
boundary condition: true
initial concentration: NaN
name: ATP1A2
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:477
is: P50993

metaR EX glyc LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycerol exchange
type: Reaction

metaR NACHEXA12ly
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is: SBO:0000176
fast: false
type: Reaction
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
product: MODEL1310110026#
modifier: MODEL1310110026#
name: beta-N-acetylhexosaminidase A, lysosomal

metaR FAOXC15ATPx
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C15)x
type: Reaction

metaM occoa c
boundary condition: false
is: C01944
initial amount: NaN
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
type: Species
constant: false
is: SBO:0000247
name: Octanoyl-CoA (n-C8:0CoA)
initial concentration: 1.0
has only substance units: false
is: CHEBI:57386
is: HMDB01070

metaM 1p3h5c c
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:6151
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB01369
type: Species
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281

metaM acetone m
has only substance units: false
is: HMDB01659
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
name: acetone
is: CHEBI:15347
constant: false
is: SBO:0000247
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207

metaM c16dc c
is: SBO:0000247
type: Species
name: Hexadecanedioic acid mono-L-carnitine ester
notes: FORMULA: C23H42NO6 CHARGE: -1
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB00712
boundary condition: false
has only substance units: false

metaR r1254
type: Reaction
reversible: false
kinetic law: MODEL1310110026#
fast: false
name: EC:6.2.1.3
reactant: MODEL1310110026#
product: MODEL1310110026#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:

metaR r2087
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reactant: MODEL1310110026#
type: Reaction
product: MODEL1310110026#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
kinetic law: MODEL1310110026#
reversible: true
modifier: MODEL1310110026#
is described by: ECO:0000000

metaM CE5101 m
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
is: SBO:0000247
is: CHEBI:57795
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_522a460c_9c47_47cf_b211_3a9ebe3d8757
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
name: B3GALNT1
is encoded by: hsa:8706
is: O75752

metaM g6p c
is: CHEBI:61548
type: Species
is: C00092
has only substance units: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB01401
name: D-Glucose 6-phosphate
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110026#_d68a7452_1803_4361_984d_6ec1eed25afb
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:522
is: Q6IB54
name: ATP5J
is: SBO:0000252
type: Species

metaM ak2lgchol hs c
is: SBO:0000247
type: Species
is: C04317
is: http://identifiers.org/pubchem.compound/6975
name: 1-alkyl 2-lysoglycerol 3-phosphocholine
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317

metaR sink tetdec2coa LPAREN c RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: TETDEC2COASINK
type: Reaction

metaR TCYNTtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
name: Thiocyanate transport via diffusion (mitochondrial)
reactant: MODEL1310110026#
reversible: false
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110026#
product: MODEL1310110026#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110026#_2ea20b51_c576_4ae1_b6a4_b5d83c041253
has only substance units: false
is encoded by: hsa:4707
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
name: NDUFB1
boundary condition: true
is: O75438
is: SBO:0000252

metaR r2082
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
type: Reaction
modifier: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
is described by: ECO:0000000

metaR r1683
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110026#
product: MODEL1310110026#
reversible: false
is: SBO:0000185

metaR HEXDIACTD
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioc acid by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_a553466a_1594_4481_87bc_53c5a80b830c
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4199
has only substance units: false
name: ME1
constant: false
is: P48163

metaM e4p c
constant: false
is: SBO:0000247
is: C00279
is: HMDB01321
initial amount: NaN
is: CHEBI:16897
boundary condition: false
has only substance units: false
name: D-Erythrose 4-phosphate
type: Species
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
initial concentration: 1.0

metaM ksii core2 deg2 l
is: HMDB00143
has only substance units: false
is: CHEBI:12936
initial concentration: 1.0
notes: FORMULA: C70H114N5O56S2X CHARGE: -2
boundary condition: false
is: SBO:0000247
type: Species
name: keratan sulfate II (core 2-linked), degradation product 2
initial amount: NaN
constant: false

metaR UMPK
product: MODEL1310110026#
kinetic law: MODEL1310110026#
fast: false
reactant: MODEL1310110026#
name: UMP kinase
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
reversible: true
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR RE3628M
product: MODEL1310110026#
reversible: true
is version of: http://identifiers.org/ec-code/5.3.3.8
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
name: RE3628
modifier: MODEL1310110026#
reactant: MODEL1310110026#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is: SBO:0000176

metaM dhf c
is: SBO:0000247
initial amount: NaN
is: HMDB01056
is: CHEBI:57451
name: 7,8-Dihydrofolate
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
constant: false
is: C00415
type: Species

metaM ksi pre6 g
constant: false
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 6
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C107H174N7O80SX CHARGE: -2
is: C00130
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:58053
has only substance units: false

metaR r2081
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
type: Reaction
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reversible: true
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_7d1c9e73_1c5f_4785_bb8a_68a248f6ae20
initial amount: NaN
boundary condition: true
type: Species
constant: false
has only substance units: false
name: PNPO
is encoded by: hsa:55163
is: Q9NVS9
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_036e500f_43c2_4231_b94b_119a29a7fc1e
constant: false
has only substance units: false
is encoded by: hsa:587
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
name: BCAT2
is: O15382
boundary condition: true

metaR r0990
fast: false
is: SBO:0000185
kinetic law: MODEL1310110026#
is described by: ECO:0000000
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
reversible: true
name: Postulated transport reaction
product: MODEL1310110026#
type: Reaction

metaR r2080
is: SBO:0000185
modifier: MODEL1310110026#
product: MODEL1310110026#
is described by: ECO:0000000
reactant: MODEL1310110026#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
kinetic law: MODEL1310110026#
reversible: true

metaR SUBERCROT
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberyl carnitine
type: Reaction

metaR PRODt2r
type: Reaction
is: SBO:0000185
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
product: MODEL1310110026#
name: D-proline reversible transport via proton symport
reversible: true
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
fast: false
reactant: MODEL1310110026#
is described by: ECO:0000304

metaR DOLPMT4 Uer
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
reactant: MODEL1310110026#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110026#
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
reversible: false
is: SBO:0000185
fast: false

metaR GCHOLAte
is: SBO:0000185
kinetic law: MODEL1310110026#
name: bile acid intracellular transport
is described by: ECO:0000000
type: Reaction
product: MODEL1310110026#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reactant: MODEL1310110026#
fast: false

metaM h2o2 c
type: Species
is: HMDB03125
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: Hydrogen peroxide
is: CHEBI:16240
is: C00027
boundary condition: false
has only substance units: false

metaR GALASE10ly
reactant: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
reversible: false
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: beta-galactosidase, lysosomal
is described by: ECO:0000000

metaR CSEPASEly
is described by: ECO:0000000
product: MODEL1310110026#
name: chondroitin sulfate E proteoglycan protease, lysosome (endosome)
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
is: SBO:0000176
fast: false
reactant: MODEL1310110026#
type: Reaction
reversible: false
kinetic law: MODEL1310110026#

metaR NDPK4n
fast: false
type: Reaction
name: nucleoside-diphosphate kinase (ATP:dTDP), nuclear
modifier: MODEL1310110026#
is described by: ECO:0000304
reversible: true
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
reactant: MODEL1310110026#
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
kinetic law: MODEL1310110026#

metaR r2084
reactant: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
product: MODEL1310110026#
fast: false
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reversible: true
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR DNDPt22m
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110026#
product: MODEL1310110026#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110026#
reversible: false
modifier: MODEL1310110026#
name: dTDP transport via dUDP antiport

metaR r1257
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
name: EC:6.2.1.3
fast: false
reactant: MODEL1310110026#
product: MODEL1310110026#
reversible: false
kinetic law: MODEL1310110026#
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110026#_05648abe_dbbe_4020_9340_10df186bfa16
is encoded by: hsa:491
is: Q4J699
boundary condition: true
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
name: ATP2B2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_03fc0541_d8d4_4a9d_b076_6d0203a2a525
type: Species
has part: P08237
is encoded by: hsa:5213
is: SBO:0000297
name: PFKM:PFKP
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true

metaM hdca c
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: HMDB00220
name: palmitate
is: CHEBI:7896
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110026#_ec6f7241_8842_47d4_bdbb_92e7eb795810
initial amount: NaN
type: Species
is encoded by: hsa:5152
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
name: PDE9A
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110026#_e38a9fbd_fc46_496d_9b36_7afb0979215c
type: Species
is: Q96PE3
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:3631
name: INPP4A
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_83d5eec6_25a7_432e_a91d_d5a48ee777c6
type: Species
initial amount: NaN
is encoded by: hsa:2878
has only substance units: false
name: GPX3
constant: false
is: SBO:0000252
is: P22352
boundary condition: true
initial concentration: NaN

metaR AG13T14g
fast: false
modifier: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110026#
reversible: false
product: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_c474ba3b_9751_4562_b483_94a7ff0b3357
boundary condition: true
type: Species
is: Q9NUB1
has only substance units: false
is encoded by: hsa:84532
name: ACSS1
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR r2083
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110026#
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
product: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_e83a8a1e_e23a_48d1_a244_3bf1c824b6f1
is encoded by: hsa:5959
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: RDH5
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: Q92781

http://identifiers.org/biomodels.db/MODEL1310110026#_87f86a27_63f6_4809_81d7_78181a8a610b
initial concentration: NaN
initial amount: NaN
name: ESD
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:2098
type: Species
is: P10768
has only substance units: false

metaR MANter
reversible: false
name: mannose efflux from endoplasmic reticulum
type: Reaction
kinetic law: MODEL1310110026#
product: MODEL1310110026#
fast: false
reactant: MODEL1310110026#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000

metaR DM dgpi prot hs r
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dgpi prot hs(r)
type: Reaction

metaM ksi deg30 l
is: HMDB00143
name: keratan sulfate I, degradation product 30
notes: FORMULA: C90H147N6O75S3 CHARGE: -3
is: CHEBI:12936
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
constant: false

metaR D 3AIBt
reactant: MODEL1310110026#
name: D-3-amino-isobutyrate transport
kinetic law: MODEL1310110026#
is described by: ECO:0000000
type: Reaction
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110026#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110026#_a1d1fd41_84a7_452d_bd77_1e11fd09866a
is: SBO:0000252
constant: false
has only substance units: false
is: B3KUV7
type: Species
is encoded by: hsa:5277
boundary condition: true
initial amount: NaN
name: PIGA
initial concentration: NaN

metaR ALOX5
type: Reaction
is version of: http://identifiers.org/ec-code/1.13.11.34
product: MODEL1310110026#
fast: false
name: Arachidonate 5-lipoxygenase
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:2829172 NOTES:cofactors + usage still not clear see version ALOX5b for ATP concomittant hydrolysis - literature notes in vitro requirement for Ca and ATP for activity in addition to Fe
reactant: MODEL1310110026#
is described by: ECO:0000269
modifier: MODEL1310110026#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110026#

metaM ksi pre35 g
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:28067
notes: FORMULA: C241H384N17O205S11X CHARGE: -12
initial amount: NaN
constant: false
name: keratan sulfate I biosynthesis, precursor 35
type: Species
boundary condition: false

metaM dadp c
is: C00206
has only substance units: false
is: CHEBI:57667
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
name: dADP
initial amount: NaN
is: HMDB01508
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
boundary condition: false

metaR EX tag hs LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: triacylglycerol (homo sapiens) exchange
type: Reaction

metaM HC02206 c
type: Species
name: prostaglandin C1(1-)
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
is: CHEBI:57399
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaR LACLt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMCID: PMC1820816. NOTES:for regeneration of nad in peroxisomes, for providing nad to the beta oxidation
name: Lactate transport
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
fast: false
is described by: ECO:0000134
type: Reaction
product: MODEL1310110026#

metaR G13MT U
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (85365.1) or (85365.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.132 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reversible: false
product: MODEL1310110026#
name: Glycolipid 1,3-alpha-D-mannosyltransferase (uterus)
is version of: http://identifiers.org/ec-code/2.4.1.132
fast: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110026#
reactant: MODEL1310110026#

metaR DLNLCGt
fast: false
type: Reaction
reversible: true
is described by: ECO:0000000
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
name: fatty acid transport via diffusion
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110026#_f18d1533_0e77_4334_a790_3d0b9ce4db36
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
constant: false
name: PDE9A
is encoded by: hsa:5152

metaM pi g
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:43474
is: SBO:0000247
name: hydrogenphosphate
is: HMDB00973
initial concentration: 1.0

metaM cholate e
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
type: Species
is: CHEBI:29747
boundary condition: false
is: SBO:0000247
is: HMDB00619
name: Cholate

http://identifiers.org/biomodels.db/MODEL1310110026#_0167591e_0b01_4775_8af1_4d28a8d73560
constant: false
is encoded by: hsa:11238
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
is: Q9Y2D0
is: SBO:0000252
has only substance units: false
name: CA5B

metaM sgalside hs g
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58343
constant: false
type: Species
boundary condition: false
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
name: sulfatide galactocerebroside
is: SBO:0000247
is: HMDB00061

http://identifiers.org/biomodels.db/MODEL1310110026#_3237bd13_ca45_465e_86ea_8909a05318f8
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:37
initial amount: NaN
is: P49748
name: ACADVL

http://identifiers.org/biomodels.db/MODEL1310110026#_1ca31a81_b609_4042_af24_9ba9ea006337
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
is: P17812
name: CTPS1
is: SBO:0000252
is encoded by: hsa:1503
type: Species
has only substance units: false

metaR r0181
product: MODEL1310110026#
type: Reaction
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110026#
modifier: MODEL1310110026#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5

http://identifiers.org/biomodels.db/MODEL1310110026#_8c0daa9a_2c7a_4572_82bd_ca241787a44e
has only substance units: false
initial amount: NaN
type: Species
has part: Q15067
initial concentration: NaN
is: SBO:0000297
boundary condition: true
name: EHHADH:ACAA1:ACOX1
constant: false
is encoded by: hsa:51

http://identifiers.org/biomodels.db/MODEL1310110026#_ff687d2f_aa17_4dd4_8eea_b7c95f6e3692
name: CHAT
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: D3DX95
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:1103

metaR ARACHt
reversible: true
product: MODEL1310110026#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
name: fatty acid transport via diffusion
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false

metaM tyr L e
boundary condition: false
is: HMDB00158
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17895
has only substance units: false
name: L-tyrosine
type: Species
is: SBO:0000247
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085

http://identifiers.org/biomodels.db/MODEL1310110026#_53cb1f9a_3db4_4295_af08_2b675e0ef6d5
is encoded by: hsa:6319
initial concentration: NaN
has only substance units: false
constant: false
type: Species
name: SCD
initial amount: NaN
is: SBO:0000252
is: O00767
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110026#_13a386dc_19b3_49c3_9758_c32bcaca8393
type: Species
name: SLC23A1
constant: false
is encoded by: hsa:9963
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: Q9UHI7
has only substance units: false
initial amount: NaN

metaR EX 3aib D LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-3-Amino-isobutanoate exchange
type: Reaction

metaR NDP3ex
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.6
kinetic law: MODEL1310110026#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:EC is 3.6.1.42? NCD
modifier: MODEL1310110026#
name: nucleoside-diphosphatase (GDP), extracellular
reactant: MODEL1310110026#
is described by: ECO:0000269
product: MODEL1310110026#
type: Reaction

metaR H2Otg
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
type: Reaction
name: H2O transport, Golgi apparatus
reactant: MODEL1310110026#
fast: false
product: MODEL1310110026#

metaM HC02206 e
initial concentration: 1.0
constant: false
name: prostaglandin C1(1-)
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
is: CHEBI:57399
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species

metaR r0560
is: SBO:0000176
fast: false
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reversible: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:

metaR FAOXC241181x
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 30.1 and 1962.1) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c24:1 -> c18:1 - 3 rounds beta-ox 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
modifier: MODEL1310110026#
is described by: ECO:0000269
type: Reaction
name: Beta oxidation of long chain fatty acid
product: MODEL1310110026#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110026#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.16

metaM ksii core2 pre8 g
boundary condition: false
constant: false
is: CHEBI:58053
initial concentration: 1.0
notes: FORMULA: C75H121N6O56SX CHARGE: -2
has only substance units: false
type: Species
is: HMDB00175
is: SBO:0000247
initial amount: NaN
is: C00130
name: keratan sulfate II biosynthesis, precursor 8

metaR PEPCKm
is version of: http://identifiers.org/ec-code/4.1.1.32
is described by: ECO:0000000
type: Reaction
fast: false
reversible: false
notes: GENE_ASSOCIATION: (5106.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.1.32 Confidence Level: 0 AUTHORS: PMID:8645161 NOTES:
product: MODEL1310110026#
kinetic law: MODEL1310110026#
is: SBO:0000176
reactant: MODEL1310110026#
name: Phosphoenolpyruvate carboxykinase (GTP)
modifier: MODEL1310110026#

metaR r2346
name: Organic anion transporter 5 Utilized transport
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110026#
is: SBO:0000185
product: MODEL1310110026#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110026#_2957500b_ce85_456f_ad02_37b6083e67db
initial concentration: NaN
type: Species
name: ADCY7
is: SBO:0000252
boundary condition: true
is encoded by: hsa:113
constant: false
has only substance units: false
is: P51828
initial amount: NaN

metaR THRGLYexR
is described by: ECO:0000304
reactant: MODEL1310110026#
modifier: MODEL1310110026#
name: L-threonine/glycine reversible exchange
fast: false
type: Reaction
product: MODEL1310110026#
is: SBO:0000185
kinetic law: MODEL1310110026#
reversible: true
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110026#_6b117930_f043_4734_8660_7ad45063e583
constant: false
is: O60488
initial concentration: NaN
is encoded by: hsa:2182
name: ACSL4
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252

metaM cholate c
type: Species
boundary condition: false
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
is: HMDB00619
is: CHEBI:29747
initial amount: NaN
name: Cholate
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110026#_fef5478d_84ea_4102_ae9d_70955b39667f
type: Species
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: ATP5B
has only substance units: false
is: SBO:0000252
is encoded by: hsa:506
is: P06576

metaM Asn X Ser Thr r
initial concentration: 1.0
constant: false
boundary condition: false
name: protein-linked asparagine residue (N-glycosylation site)
notes: FORMULA: XH CHARGE: 0
is: SBO:0000247
is: CHEBI:28938
is: C01342
initial amount: NaN
type: Species
has only substance units: false
is: HMDB00051

metaR r2347
product: MODEL1310110026#
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
type: Reaction
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
is: SBO:0000185

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_5aa19136_9d53_41a0_8a76_1da411b4215c
constant: false
initial concentration: NaN
boundary condition: true
name: ENTPD8
has only substance units: false
initial amount: NaN
is encoded by: hsa:377841
is: Q5MY95
type: Species
is: SBO:0000252

metaR G14T2g
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false
reactant: MODEL1310110026#
modifier: MODEL1310110026#
product: MODEL1310110026#
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110026#_4cc4ed8e_dd69_41f3_b5bf_9ec2235f2ee3
constant: false
is encoded by: hsa:5332
is: SBO:0000252
name: PLCB4
initial amount: NaN
has only substance units: false
is: Q15147
type: Species
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110026#_5816a74f_ff3f_4330_95cc_64e5cfeb39dc
is: O00443
boundary condition: true
is encoded by: hsa:5286
has only substance units: false
initial amount: NaN
constant: false
name: PIK3C2A
initial concentration: NaN
is: SBO:0000252
type: Species

metaM CE5161 r
boundary condition: false
is: CHEBI:57923
has only substance units: false
constant: false
name: 3(S)-hydroxy-cis-9-octadecenoyl-CoA
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C39H64N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-28,32-34,38,47,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5161

metaM cs b deg2 l
is: HMDB01354
is: CHEBI:57455
initial concentration: 1.0
initial amount: NaN
constant: false
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 2
boundary condition: false
type: Species
notes: FORMULA: C37H54NO41S3 CHARGE: -5
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_25fcfbed_0f41_4153_9806_0567319c1ab5
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:3612
boundary condition: true
constant: false
has only substance units: false
is: B7Z6Q4
initial amount: NaN
name: IMPA1

metaR THYOXt
is: SBO:0000185
reversible: true
modifier: MODEL1310110026#
product: MODEL1310110026#
type: Reaction
reactant: MODEL1310110026#
fast: false
name: T4 transport via bicarbonate countertransport
is described by: ECO:0000269
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (53919.1) or (6579.1) or (28231.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ

metaM pectintchol e
type: Species
has only substance units: false
constant: false
notes: FORMULA: C2561H3555NO2542S CHARGE: 0
initial amount: NaN
initial concentration: 1.0
name: pectin-taurocholic acid complex
is: SBO:0000247
is: HMDB03402
boundary condition: false

metaM damp c
constant: false
is: SBO:0000247
name: dAMP(2-)
initial amount: NaN
type: Species
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
is: CHEBI:58245
boundary condition: false
has only substance units: false
is: HMDB00905
initial concentration: 1.0

metaR r2079
product: MODEL1310110026#
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
is described by: ECO:0000000
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is: SBO:0000185
type: Reaction
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR EX pydx5p LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of pyridoxal 5-phosphate(2-)
type: Reaction

metaM sgalside hs c
is: CHEBI:16523
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
name: sulfatide galactocerebroside
is: HMDB03406
constant: false
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaM nadp x
type: Species
is: CHEBI:58349
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB00217
boundary condition: false
name: Nicotinamide adenine dinucleotide phosphate
is: C00006
constant: false

metaM dcmp n
initial amount: NaN
has only substance units: false
name: dCMP(2-)
is: SBO:0000247
is: HMDB01202
type: Species
boundary condition: false
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
constant: false
initial concentration: 1.0
is: CHEBI:57566

http://identifiers.org/biomodels.db/MODEL1310110026#_a762b4b4_5928_4cdd_b9a0_ae8d8b6af1bb
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: P06132
is encoded by: hsa:7389
boundary condition: true
has only substance units: false
name: UROD

metaM acngalgbside hs g
boundary condition: false
type: Species
has only substance units: false
constant: false
is: CHEBI:16523
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C61H105N3O35FULLRCO CHARGE: -1
is: HMDB03406
initial amount: NaN
name: sialyl galactosylgloboside

http://identifiers.org/biomodels.db/MODEL1310110026#_27962282_f7bc_4713_be73_9bfc6597f065
type: Species
boundary condition: true
is encoded by: hsa:8818
is: SBO:0000252
constant: false
name: DPM2
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaR SUBEACTD
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberic acid into cytosol (diffusion)
type: Reaction

metaM ac e
name: acetate
is: HMDB00042
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
type: Species
is: CHEBI:30089

metaR N2M2NMASNtly
is: SBO:0000185
is described by: ECO:0000000
name: n2m2nmasn transport, extracellular to lysosome
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
fast: false
type: Reaction
reversible: false

metaR EX ivcrn
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for isovaleryl carnitine
type: Reaction

metaM 3mop e
is: CHEBI:28654
name: 3-methyl-2-oxopentanoate
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
is: HMDB00491
boundary condition: false
constant: false
has only substance units: false
type: Species

metaR AHCYStd
reactant: MODEL1310110026#
is: SBO:0000185
kinetic law: MODEL1310110026#
reversible: true
fast: false
is described by: ECO:0000134
type: Reaction
name: diffusion of S-Adenosyl-L-homocysteine
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:
product: MODEL1310110026#

metaR r2341
reactant: MODEL1310110026#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110026#
is: SBO:0000185
product: MODEL1310110026#
name: Organic anion transporter 5 Utilized transport
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110026#_f660ab4a_ff6a_4be2_8367_5743b0e7a242
initial concentration: NaN
name: SLC16A1
boundary condition: true
is encoded by: hsa:6566
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
is: B4DKS0
has only substance units: false

metaR ADK1m
fast: false
notes: GENE_ASSOCIATION: (205.3) or (205.1) or (204.1) or (204.3) or (204.2) or (205.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:11485571,PMID:195572,PMID:8843353,PMID:9434148 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.4.3
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reversible: true
name: adenylate kinase, mitochondrial
modifier: MODEL1310110026#
is: SBO:0000176
reactant: MODEL1310110026#
is described by: ECO:0000269
type: Reaction

metaR TYRTA
is version of: http://identifiers.org/ec-code/2.6.1.1
name: tyrosine transaminase
kinetic law: MODEL1310110026#
type: Reaction
modifier: MODEL1310110026#
reversible: true
reactant: MODEL1310110026#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110026#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110026#_f8ff9cb2_09f9_46a1_adee_01478e0be31b
has only substance units: false
initial concentration: NaN
name: ALDH3A2
boundary condition: true
is encoded by: hsa:224
is: SBO:0000252
is: P51648
initial amount: NaN
constant: false
type: Species

metaR C40CPT1
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of butyrylcarnitine
type: Reaction

metaM mal L m
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
constant: false
boundary condition: false
type: Species
is: CHEBI:15589
initial concentration: 1.0
is: HMDB00156
name: (S)-malate(2-)

http://identifiers.org/biomodels.db/MODEL1310110026#_43962d0c_9757_41b9_8bfe_08e69c42f99d
is encoded by: hsa:2653
is: SBO:0000252
name: GCSH
initial amount: NaN
is: P23434
type: Species
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_57665519_6fca_4a37_9058_8565a9da1207
boundary condition: true
constant: false
name: TKTL1
is: B7Z7I0
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:8277
initial concentration: NaN

metaM pi m
has only substance units: false
boundary condition: false
type: Species
constant: false
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial concentration: 1.0
is: C00009
name: hydrogenphosphate
initial amount: NaN
is: SBO:0000247
is: CHEBI:43474
is: HMDB00973

metaR NDPK6m
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
fast: false
reversible: true
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
type: Reaction
is described by: ECO:0000254
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
product: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.

metaR r0295
fast: false
name: glycine synthase Nitrogen metabolism EC:2.1.2.10
kinetic law: MODEL1310110026#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
is: SBO:0000176
modifier: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
type: Reaction

metaM occoa m
is: CHEBI:57386
constant: false
is: C01944
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
initial concentration: 1.0
is: HMDB01070
name: Octanoyl-CoA (n-C8:0CoA)
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110026#_70bb5924_5ab7_49ec_9db8_7ddb754f9742
boundary condition: true
is: Q9NQR4
constant: false
is: SBO:0000252
name: NIT2
has only substance units: false
is encoded by: hsa:56954
initial concentration: NaN
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_7d6c7889_c0bc_43f1_ae72_8a1236be9dd5
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:AL048840
initial amount: NaN
name: _AL048840_1_c

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_86975784_b29a_41f7_9e99_4674b65057b2
constant: false
has only substance units: false
name: ACAT2
type: Species
is encoded by: hsa:39
initial amount: NaN
is: SBO:0000252
is: Q9BWD1
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110026#_d74b8632_7af7_403f_a795_0155d9fe2a1d
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
name: SLC8A3
is encoded by: hsa:6547
initial amount: NaN

metaR G14T16g
type: Reaction
modifier: MODEL1310110026#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.38
reversible: false
kinetic law: MODEL1310110026#
is described by: ECO:0000000
product: MODEL1310110026#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110026#

metaM pi n
has only substance units: false
is: HMDB00973
name: hydrogenphosphate
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:43474
boundary condition: false
type: Species
constant: false
initial amount: NaN

metaR GLYOp
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9038835 NOTES:
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
name: glycine oxidase, perixosomal
reversible: false
is described by: ECO:0000000
product: MODEL1310110026#
type: Reaction

metaM HC01610 e
is: SBO:0000247
name: CoproporphyrinogenI
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768
type: Species
is: CHEBI:28607
constant: false
has only substance units: false

metaM 3mop c
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: 3-methyl-2-oxopentanoate
is: HMDB00491
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
is: CHEBI:28654

http://identifiers.org/biomodels.db/MODEL1310110026#_04886c92_dba4_4ae2_83b3_ea308f484755
name: ENTPD3
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:956
is: SBO:0000252
initial amount: NaN
type: Species
is: O75355
constant: false

metaM cgly e
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
constant: false
has only substance units: false
is: HMDB00078
name: L-cysteinylglycine
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:4047
initial amount: NaN

metaM oh1 e
initial amount: NaN
name: hydroxide ion
notes: FORMULA: HO CHARGE: -1
is: C01328
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01039
type: Species
boundary condition: false

metaM HC01842 c
constant: false
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
initial amount: NaN
is: CHEBI:31997
name: Phosphodimethylethanolamine
initial concentration: 1.0
is: SBO:0000247

metaM btamp m
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
type: Species
is: HMDB04220
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:3110
name: Biotinyl-5'-AMP
is: SBO:0000247
initial concentration: 1.0

metaR C141CPT1
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tetradecenoylcarnitine
type: Reaction

metaR NACHEXA13ly
type: Reaction
kinetic law: MODEL1310110026#
product: MODEL1310110026#
is described by: ECO:0000000
reactant: MODEL1310110026#
name: beta-N-acetylhexosaminidase A, lysosomal
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
fast: false
modifier: MODEL1310110026#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false

metaM ksii core4 pre7 g
is: C00130
is: SBO:0000247
notes: FORMULA: C75H121N6O56SX CHARGE: -2
boundary condition: false
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 7
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:58053
has only substance units: false
is: HMDB00175

metaR H2Otm
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
reactant: MODEL1310110026#
name: H2O transport, mitochondrial
product: MODEL1310110026#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF

metaR HACD9m
product: MODEL1310110026#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110026#
reversible: true
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid

metaR sink 5hpet LPAREN c RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: sink reaction for 5(S)-HPETE(1-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_59b653ca_0845_42f0_af12_39dab450c3a5
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:56953
is: Q9NPB1
initial concentration: NaN
has only substance units: false
name: NT5M
initial amount: NaN
type: Species

metaR r1109
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
reactant: MODEL1310110026#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110026#
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
fast: false
type: Reaction
kinetic law: MODEL1310110026#
reversible: true

metaR SPODMm
type: Reaction
modifier: MODEL1310110026#
name: superoxide dismutase
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.15.1.1
is described by: ECO:0000304
fast: false
reversible: false
is: SBO:0000176
product: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (6648.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 2 AUTHORS: PMID:12649272,PMID:9376114 NOTES:TV (8-15-2003)

metaM gal1p c
type: Species
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3+,4+,5-,6-/m1/s1 EHMN_ABBREVIATION: C00446
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
name: (2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphate
is: CHEBI:58336
initial amount: NaN
is: HMDB00645

http://identifiers.org/biomodels.db/MODEL1310110026#_ae2540f5_6581_48ef_b430_1c8f21e3ae97
is: Q9NWU1
initial concentration: NaN
type: Species
name: OXSM
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:54995
constant: false
has only substance units: false

metaR DCK1n
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.7.1.74
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
kinetic law: MODEL1310110026#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110026#
reversible: true
fast: false
is: SBO:0000176
name: Deoxycytidine kinase, nuclear (ATP)

http://identifiers.org/biomodels.db/MODEL1310110026#_b7526e1b_aaa8_44a5_bb6b_48da89d1a20a
is: SBO:0000297
constant: false
has part: P55084
type: Species
is encoded by: hsa:3030
has part: E9KL44
name: HADHA:HADHB
initial concentration: NaN
is encoded by: hsa:3032
initial amount: NaN
boundary condition: true
has only substance units: false

metaR PPAt
product: MODEL1310110026#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8135845 NOTES:TDV
fast: false
kinetic law: MODEL1310110026#
reversible: false
name: Propionate transport, diffusion
reactant: MODEL1310110026#

metaM h2o2 x
has only substance units: false
type: Species
is: C00027
initial concentration: 1.0
is: CHEBI:16240
initial amount: NaN
constant: false
is: HMDB03125
name: Hydrogen peroxide
boundary condition: false
is: SBO:0000247
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027

metaM sphs1p r
is: CHEBI:60119
boundary condition: false
is: HMDB00277
initial concentration: 1.0
constant: false
initial amount: NaN
name: sphingosine 1-phosphate(1-)
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124

metaM cgly c
is: HMDB00078
type: Species
initial concentration: 1.0
is: CHEBI:4047
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
name: L-cysteinylglycine

metaR RE1534M
fast: false
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
product: MODEL1310110026#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
reactant: MODEL1310110026#
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
reversible: true
name: RE1534

http://identifiers.org/biomodels.db/MODEL1310110026#_d14f033d_1fed_4dca_bead_ffc444d1caa6
is: SBO:0000252
is encoded by: hsa:79717
type: Species
is: Q9HAB8
initial amount: NaN
constant: false
initial concentration: NaN
name: PPCS
boundary condition: true
has only substance units: false

metaM etoh e
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:16236
has only substance units: false
is: HMDB00108
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
is: SBO:0000247
constant: false
initial amount: NaN
name: ethanol

metaR r0145
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
modifier: MODEL1310110026#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110026#
is described by: ECO:0000000
reactant: MODEL1310110026#
reversible: true
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.8.3.1
fast: false

metaR PRO1xm
fast: false
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:NCD
name: proline oxidase (NAD), mitochondrial
is version of: http://identifiers.org/ec-code/1.5.99.8
kinetic law: MODEL1310110026#
is described by: ECO:0000254
product: MODEL1310110026#
reactant: MODEL1310110026#
modifier: MODEL1310110026#
is: SBO:0000176
reversible: false
type: Reaction

metaR H2Otn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
fast: false
product: MODEL1310110026#
type: Reaction
reversible: true
is described by: ECO:0000000
name: H2O transport, nuclear
is: SBO:0000185

metaR HMGCOARc
reversible: false
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). enzyme is located in E.R. but has catalytic site facing the cytosol (D.S. Sheriff (2004) Medical biochemistry, 1st edition Jaypee brothers Medical publishers pvt ltd page 502).
modifier: MODEL1310110026#
is: SBO:0000176
name: Hydroxymethylglutaryl CoA reductase (ir) in cytosol
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
fast: false
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.1.1.34
is described by: ECO:0000134
type: Reaction

metaR GLCtg
modifier: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000269
reversible: true
product: MODEL1310110026#
name: glucose transport, Golgi apparatus
type: Reaction
notes: GENE_ASSOCIATION: (6513.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15384581 NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110026#
fast: false

metaM CE4790 m
boundary condition: false
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
is: CHEBI:57923
type: Species
is: SBO:0000247

metaM oh1 c
initial concentration: 1.0
type: Species
name: hydroxide ion
is: C01328
is: SBO:0000247
notes: FORMULA: HO CHARGE: -1
initial amount: NaN
boundary condition: false
constant: false
is: HMDB01039
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_97189e9e_2d07_4ce1_b049_1ce3d91a9a9d
is: P55084
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3032
type: Species
has only substance units: false
constant: false
is: SBO:0000252
name: HADHB

metaR FE3MTP1
type: Reaction
notes: GENE_ASSOCIATION: (30061.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
is: SBO:0000185
is described by: ECO:0000134
product: MODEL1310110026#
kinetic law: MODEL1310110026#
name: transport of ferrous iron into blood
fast: false
modifier: MODEL1310110026#
reversible: false
reactant: MODEL1310110026#

metaR SRTNtu
is: SBO:0000185
reversible: true
product: MODEL1310110026#
fast: false
name: Serotonin uniport
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (6580.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
kinetic law: MODEL1310110026#
type: Reaction
reactant: MODEL1310110026#
is described by: ECO:0000269

metaM asp L e
initial concentration: 1.0
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
name: L-aspartate(1-)
boundary condition: false
is: SBO:0000247
is: CHEBI:29991
has only substance units: false
is: HMDB00191
constant: false
initial amount: NaN
type: Species

metaR r0142
type: Reaction
kinetic law: MODEL1310110026#
is described by: ECO:0000000
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
reversible: false
product: MODEL1310110026#
reactant: MODEL1310110026#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.5
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1

metaR PYAM5POr
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.4.3.5
product: MODEL1310110026#
name: pyridoxamine 5'-phosphate oxidase
reversible: true
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:6380540 NOTES:NCD IT
fast: false
modifier: MODEL1310110026#
type: Reaction
is: SBO:0000176
is described by: ECO:0000269

metaR RE2269E
reversible: true
name: RE2269
product: MODEL1310110026#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.4.21.39
reactant: MODEL1310110026#
fast: false
modifier: MODEL1310110026#

metaR r0186
modifier: MODEL1310110026#
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.5
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
type: Reaction
product: MODEL1310110026#
kinetic law: MODEL1310110026#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
is: SBO:0000176

metaR AG13T1g
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110026#
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is: SBO:0000176
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (374907.2) or (374907.1) or (146712.1) or (10331.1) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false
product: MODEL1310110026#
is described by: ECO:0000000

metaR EX vacc LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: vaccenic acid exchange
type: Reaction

metaR H2Otp
name: H2O transport, peroxisomal
kinetic law: MODEL1310110026#
reversible: true
type: Reaction
reactant: MODEL1310110026#
is described by: ECO:0000000
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
fast: false

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

metaR ETOHt
reversible: true
type: Reaction
is: SBO:0000185
product: MODEL1310110026#
kinetic law: MODEL1310110026#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: NOTES:NCD
name: ethanol reversible transport
reactant: MODEL1310110026#
fast: false

metaM etoh c
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:16236
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
name: ethanol
is: HMDB00108
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false

metaR r1106
reactant: MODEL1310110026#
type: Reaction
reversible: true
kinetic law: MODEL1310110026#
is described by: ECO:0000000
fast: false
is: SBO:0000185
name: Postulated transport reaction
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

metaM ac c
is: CHEBI:30089
is: HMDB00042
initial concentration: 1.0
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
name: acetate

http://identifiers.org/biomodels.db/MODEL1310110026#_96ef915e_8299_4355_84e8_776eff6623b7
is: P08842
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
name: STS
is encoded by: hsa:412

metaM pi r
name: hydrogenphosphate
boundary condition: false
is: C00009
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:43474
has only substance units: false
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: HMDB00973
initial amount: NaN

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_a3f75bd2_e394_4668_bfab_5145a69d68f8
boundary condition: true
is: Q16718
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4698
has only substance units: false
constant: false
type: Species
name: NDUFA5
initial concentration: NaN

metaR r0456
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
reactant: MODEL1310110026#
fast: false
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
product: MODEL1310110026#
type: Reaction
modifier: MODEL1310110026#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.32

metaR UGCG
notes: GENE_ASSOCIATION: (7357.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES:NJ
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110026#
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.4.1.80
kinetic law: MODEL1310110026#
name: Ceramide glucosyltransferase
is: SBO:0000176
type: Reaction
reactant: MODEL1310110026#
fast: false

metaM prist c
constant: false
type: Species
name: pristanic acid
is: SBO:0000247
boundary condition: false
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
is: HMDB00795
is: CHEBI:51340
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR GLCAASE4ly
is: SBO:0000176
name: beta-glucuronidase, lysosomal
reactant: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.31
product: MODEL1310110026#
reversible: false
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_cf364006_f7a5_4acb_96ff_fa13bb4fd3dc
is encoded by: hsa:3906
is: SBO:0000252
has only substance units: false
type: Species
constant: false
boundary condition: true
name: LALBA
initial amount: NaN
is: P00709
initial concentration: NaN

metaM asp L c
name: L-aspartate(1-)
boundary condition: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
is: SBO:0000247
has only substance units: false
is: CHEBI:29991
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB00191
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_48cf6ce2_81b6_4724_8bb2_90e3c2da7983
is encoded by: hsa:343
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: O94778
name: AQP8
constant: false
boundary condition: true
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_d5473264_a78f_4b78_ab4e_f3624197943a
is: SBO:0000252
has only substance units: false
is: O14975
type: Species
boundary condition: true
is encoded by: hsa:11001
constant: false
initial concentration: NaN
name: SLC27A2
initial amount: NaN

metaM 2mbcoa m
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
has only substance units: false
name: 2-methylbutanoyl-CoA(4-)
type: Species
is: HMDB01041
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:57336
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110026#_067d47b0_3a44_469c_9022_f608bd8e4bfc
initial concentration: NaN
is encoded by: hsa:10476
is: A0PJH2
type: Species
is: SBO:0000252
initial amount: NaN
name: ATP5H
constant: false
boundary condition: true
has only substance units: false

metaM uacgam r
type: Species
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
is: SBO:0000247
constant: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
boundary condition: false
initial amount: NaN
is: HMDB00290
has only substance units: false
initial concentration: 1.0
is: CHEBI:57705

metaM pristcoa c
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:51341
name: pristanoyl coa
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
is: SBO:0000247

metaR NRVNCt
reversible: true
is described by: ECO:0000000
name: fatty acid transport via diffusion
type: Reaction
fast: false
kinetic law: MODEL1310110026#
is: SBO:0000185
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110026#

metaR FRDPtcr
is: SBO:0000185
type: Reaction
reactant: MODEL1310110026#
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
fast: false
reversible: true
kinetic law: MODEL1310110026#
is described by: ECO:0000134
name: transport of Farnesyl diphosphate into the endoplasmic reticulum

metaR ACNAMtn
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
kinetic law: MODEL1310110026#
name: N-acetylneuraminate nuclear import
reactant: MODEL1310110026#
reversible: false
is described by: ECO:0000000
fast: false
product: MODEL1310110026#

metaR PMEVKc
name: phosphomevalonate kinase, cytosol
is version of: http://identifiers.org/ec-code/2.7.4.2
modifier: MODEL1310110026#
fast: false
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (10654.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added to substrate for elemental balancing.
is described by: ECO:0000134
product: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_719e3e08_93ff_4685_92aa_7498541ba787
boundary condition: true
initial amount: NaN
is: P35354
is encoded by: hsa:5743
is: SBO:0000252
constant: false
name: PTGS2
has only substance units: false
initial concentration: NaN
type: Species

metaM ksi pre19 g
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C171H275N12O137S5X CHARGE: -6
is: C00130
has only substance units: false
constant: false
name: keratan sulfate I biosynthesis, precursor 19
is: HMDB00175
is: CHEBI:58053
initial concentration: 1.0

metaM btamp c
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:3110
is: HMDB04220
is: SBO:0000247
constant: false
name: Biotinyl-5'-AMP
initial concentration: 1.0
boundary condition: false

metaR r0450
type: Reaction
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
is described by: ECO:0000000
kinetic law: MODEL1310110026#
fast: false
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
product: MODEL1310110026#
is: SBO:0000176
modifier: MODEL1310110026#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.3

metaR DOLDPP Uer
is version of: http://identifiers.org/ec-code/3.6.1.43
is: SBO:0000176
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (57171.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.6.1.43 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:NCD
modifier: MODEL1310110026#
fast: false
kinetic law: MODEL1310110026#
type: Reaction
reversible: false
reactant: MODEL1310110026#
name: Dolichyl-diphosphate phosphohydrolase, human (uterus)
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110026#_faf3c2b9_c392_4f5b_a166_acb8be1d5726
is: SBO:0000252
type: Species
name: SLC26A7
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:115111
constant: false
is: Q8TE54
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_4fbb5262_eb20_4ac3_89bd_295d29398115
is: SBO:0000252
has only substance units: false
name: NDUFV3
type: Species
constant: false
is: P56181
boundary condition: true
is encoded by: hsa:4731
initial concentration: NaN
initial amount: NaN

metaR GLCAASE8ly
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.31
fast: false
kinetic law: MODEL1310110026#
product: MODEL1310110026#
modifier: MODEL1310110026#
name: beta-glucuronidase, lysosomal
reversible: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110026#
is described by: ECO:0000269

metaM c226coa m
name: cervonyl coenzyme A
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
is: C16169
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
is: http://identifiers.org/pubchem.compound/47205479
type: Species
constant: false

metaM f6p c
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57579
constant: false
is: http://identifiers.org/pubchem.compound/3385
is: HMDB00124
is: SBO:0000247
name: D-Fructose 6-phosphate
boundary condition: false
has only substance units: false
is: C00085
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_9eedb2ad_a054_466a_ab11_d1333ee6decb
type: Species
is: SBO:0000252
has only substance units: false
is: O95992
initial amount: NaN
is encoded by: hsa:9023
constant: false
initial concentration: NaN
boundary condition: true
name: CH25H

http://identifiers.org/biomodels.db/MODEL1310110026#_bbcfb91f_44ba_4bb7_96a1_6f6eac5612f4
initial concentration: NaN
is: Q86XP1
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:160851
type: Species
boundary condition: true
constant: false
has only substance units: false
name: DGKH

metaR PPAn
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: 3.6.1.1 Confidence Level: 1 AUTHORS: NOTES:
fast: false
name: inorganic diphosphatase, nuclear
type: Reaction
is described by: ECO:0000000
product: MODEL1310110026#
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_3576f4e3_c449_4833_9077_499ffca35d98
has only substance units: false
name: MECR
boundary condition: true
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:51102
initial concentration: NaN
is: Q9BV79

metaR NAIt
kinetic law: MODEL1310110026#
type: Reaction
reversible: true
fast: false
is described by: ECO:0000269
name: Na+ / iodide cotransport
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110026#
modifier: MODEL1310110026#
product: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_b89f6323_a56c_4feb_a725_82a438759280
is: SBO:0000252
constant: false
initial concentration: NaN
is: C9JC79
initial amount: NaN
boundary condition: true
is encoded by: hsa:6342
type: Species
name: SCP2
has only substance units: false

metaR EX dlnlcg LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: dihomo-gamma-linolenic acid (n-6) exchange
type: Reaction

metaM tyr L c
boundary condition: false
is: SBO:0000247
is: HMDB00158
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
is: CHEBI:17895
name: L-tyrosine
constant: false
initial amount: NaN

metaR COQ6m
fast: false
is: SBO:0000176
modifier: MODEL1310110026#
type: Reaction
notes: GENE_ASSOCIATION: (51004.1) or (51004.2) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_1.13.12.- IT
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
name: Ubiquinone biosynthesis monooxgenase COQ6
reversible: false
is described by: ECO:0000269
product: MODEL1310110026#

metaR LTC4Sr
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.5.1.18
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/4.4.1.20
modifier: MODEL1310110026#
reactant: MODEL1310110026#
is: SBO:0000176
reversible: false
type: Reaction
name: Leukotriene C4 synthase
fast: false
notes: GENE_ASSOCIATION: (4056.1) or (4259.1) or (4056.2) or (4258.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 4.4.1.20 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:previous EC 2.5.1.37 EC: 4.4.1.20 NJ
kinetic law: MODEL1310110026#

metaM pd3 c
boundary condition: false
has only substance units: false
is: HMDB06500
initial amount: NaN
is: SBO:0000247
name: Previtamin D3
constant: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h10,12-13,19,21,24-26,28H,6-9,11,14-18H2,1-5H3/b13-12-/t21-,24+,25-,26?,27-/m1/s1
type: Species
initial concentration: 1.0

metaR PPAm
fast: false
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
name: inorganic diphosphatase
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.1
is described by: ECO:0000269
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
reactant: MODEL1310110026#
reversible: false
product: MODEL1310110026#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110026#_77b29880_63b5_4a45_8ee3_2dea0f3e7143
is: SBO:0000252
boundary condition: true
is: Q8WUX1
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:92745
name: SLC38A5
initial amount: NaN

metaR RE2954C
kinetic law: MODEL1310110026#
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.7.1.40
notes: GENE_ASSOCIATION: (5315.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:10585400,PMID:8967971 NOTES:
modifier: MODEL1310110026#
reversible: true
is described by: ECO:0000000
fast: false
reactant: MODEL1310110026#
is: SBO:0000176
type: Reaction
name: RE2954

metaR DM gpi sig er
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gpi sig(er)
type: Reaction

metaR CHOLATEt2
notes: GENE_ASSOCIATION: (6554.1) or (6555.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12851823,PMID:7592981,PMID:8132774,PMID:9109432 NOTES:electrogenic uptake NJ
fast: false
modifier: MODEL1310110026#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110026#
is: SBO:0000185
product: MODEL1310110026#
name: cholate transport via sodium cotransport
reactant: MODEL1310110026#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110026#_9a1de5f2_1ead_4602_b30b_0d10194eb9f3
name: NDUFS8
constant: false
initial amount: NaN
is: O00217
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:4728
initial concentration: NaN
boundary condition: true

metaR NAGA2ly
name: N-acetylgalactosaminidase, alpha-
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
type: Reaction
product: MODEL1310110026#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
reversible: false
modifier: MODEL1310110026#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.49

http://identifiers.org/biomodels.db/MODEL1310110026#_79665996_2a79_412f_bb65_b049f6d268f4
is: Q7Z7B1
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:284098
name: PIGW
constant: false

metaR C3DCe
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of malonyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_e6c60d72_af91_47fd_ae5a_61bdace635cc
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110026#_072987d8_f733_4b76_b4f8_5282d65a19ee
is: SBO:0000252
is: Q7LGC8
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
name: CHST3
is encoded by: hsa:9469
constant: false
initial concentration: NaN

metaM mal L c
is: CHEBI:15589
has only substance units: false
name: (S)-malate(2-)
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
is: HMDB00156
initial concentration: 1.0
boundary condition: false

metaM homoval m
initial concentration: 1.0
has only substance units: false
is: CHEBI:545959
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB00118
name: Homovanillate
notes: FORMULA: C9H9O4 CHARGE: -1 INCHI: InChI=1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12) HEPATONET_1.0_ABBREVIATION: HC01519 EHMN_ABBREVIATION: C05582
type: Species

metaR PI5P3K
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5295.2 and 5290.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.1) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5290.1 and 5295.3) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.154
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.137
name: phosphatidylinositol-5-phosphate 3-kinase
is: SBO:0000176
modifier: MODEL1310110026#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.11.1
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.7.1.153
product: MODEL1310110026#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110026#_199aab47_9909_4be6_ad43_0a4a90716025
initial concentration: NaN
initial amount: NaN
name: CDA
is: P32320
is: SBO:0000252
constant: false
is encoded by: hsa:978
type: Species
has only substance units: false
boundary condition: true

metaM ksi deg11 l
type: Species
name: keratan sulfate I, degradation product 11
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C180H289N12O158S9 CHARGE: -9
is: CHEBI:12936
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
is: HMDB00143

metaM Sfglutth c
is: SBO:0000247
has only substance units: false
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
constant: false
initial amount: NaN
name: S-formylglutathionate(1-)
is: CHEBI:57688
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB01550

http://identifiers.org/biomodels.db/MODEL1310110026#_7793b41d_dc36_4823_8187_fbf08f28231f
name: COASY
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:80347
is: SBO:0000252
constant: false
boundary condition: true
is: Q13057
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_7723303e_bd45_44bc_8250_7e484d7f9045
initial concentration: NaN
name: PIK3CB
is encoded by: hsa:5291
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
is: B4DER4
type: Species

metaR EX nrvnc LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nervonic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_941ecfc2_37ad_432f_8521_6abad9f618dd
is encoded by: hsa:5152
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
constant: false
boundary condition: true
name: PDE9A
initial concentration: NaN

metaR EX inost LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: myo-Inositol exchange
type: Reaction

metaR r1822
fast: false
is described by: ECO:0000000
type: Reaction
name: Y+LAT2 Utilized transport
product: MODEL1310110026#
modifier: MODEL1310110026#
reactant: MODEL1310110026#
reversible: false
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaM pyam5p c
notes: FORMULA: C8H12N2O5P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00475 EHMN_ABBREVIATION: C00647
initial concentration: 1.0
is: SBO:0000247
type: Species
is: C00647
is: HMDB01555
boundary condition: false
initial amount: NaN
name: Pyridoxamine 5'-phosphate
is: CHEBI:58451
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_9ef6c9fd_0947_4a24_971d_7a758cc38d40
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is: O95497
is: SBO:0000252
is encoded by: hsa:8876
initial concentration: NaN
name: VNN1
constant: false

metaM mi3p D c
name: 1D-myo-inositol 3-phosphate(2-)
initial concentration: 1.0
is: SBO:0000247
is: HMDB06814
has only substance units: false
is: CHEBI:58401
initial amount: NaN
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m0/s1
type: Species
constant: false
boundary condition: false

metaR r0139
is version of: http://identifiers.org/ec-code/2.3.2.2
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is: SBO:0000176
type: Reaction
modifier: MODEL1310110026#
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
product: MODEL1310110026#
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
reversible: true
is described by: ECO:0000000
fast: false

metaR BAAT2x
is version of: http://identifiers.org/ec-code/2.3.1.65
is: SBO:0000176
name: bile acid Coenzyme A: amino acid N-acyltransferase
is described by: ECO:0000269
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
product: MODEL1310110026#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
modifier: MODEL1310110026#
reversible: false

metaM 6pgl r
name: 6-O-phosphonato-D-glucono-1,5-lactone(2-)
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57955
is: SBO:0000247
boundary condition: false
is: HMDB01127
notes: FORMULA: C6H9O9P CHARGE: -2 INCHI: InChI=1S/C6H11O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-5,7-9H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00733 EHMN_ABBREVIATION: C01236
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_1ae68d7f_d7ef_4c20_9ec9_78e49f57bf71
initial amount: NaN
boundary condition: true
is encoded by: hsa:2530
type: Species
is: G3V5N0
is: SBO:0000252
name: FUT8
initial concentration: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_83deba57_ca75_4a90_8014_315c790e25e2
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
is: Q9NRX3
is encoded by: hsa:56901
name: NDUFA4L2
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_6559fb4c_3dcd_4552_8772_191bc0a79378
constant: false
name: _AI971036_1_c
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:AI971036
boundary condition: true
type: Species
is: SBO:0000252

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_80d42b75_9a40_4630_9986_0c4437bef7e1
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4722
initial concentration: NaN
name: NDUFS3
is: O75489
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_cc5fa4a3_833b_4f61_8420_cd801ba67502
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: Q6ZMU0
type: Species
name: ALAD
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:210

metaR r1823
is: SBO:0000185
modifier: MODEL1310110026#
fast: false
product: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110026#
name: Y+LAT2 Utilized transport

metaR ACACt2m
reactant: MODEL1310110026#
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110026#
name: Acetoacetate mitochondrial transport via H+ symport
type: Reaction
product: MODEL1310110026#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
kinetic law: MODEL1310110026#

metaR RE3003M
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/5.3.3.8
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
product: MODEL1310110026#
name: RE3003
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110026#
modifier: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_d1a68953_aca1_4ed7_b3af_4653bdaeb7bb
type: Species
is: P28331
initial concentration: NaN
initial amount: NaN
name: NDUFS1
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4719

http://identifiers.org/biomodels.db/MODEL1310110026#_6f46b87b_c1e0_4739_b3d5_6120fb09bd34
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is encoded by: hsa:53354
name: PANK1
boundary condition: true
initial amount: NaN
is: Q8TE04
is: SBO:0000252

metaR PGSr
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5743.1) or (5742.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.14.99.1 Confidence Level: 4 AUTHORS: PMID:14511332,PMID:1907252 NOTES:NJ
type: Reaction
reactant: MODEL1310110026#
is: SBO:0000176
name: Prostaglandin G/H synthase
kinetic law: MODEL1310110026#
fast: false
is version of: http://identifiers.org/ec-code/1.14.99.1
modifier: MODEL1310110026#
reversible: false
product: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_a418d384_1e78_451f_a138_810b3f80b9cc
initial concentration: NaN
is encoded by: hsa:6785
initial amount: NaN
name: ELOVL4
constant: false
is: Q9GZR5
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true

metaM subeac x
initial concentration: 1.0
has only substance units: false
is: HMDB00893
constant: false
name: suberic acid
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C8H12O4 CHARGE: -2
type: Species

metaM nadp m
is: CHEBI:58349
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
is: HMDB00217
is: SBO:0000247
is: C00006
name: Nicotinamide adenine dinucleotide phosphate
constant: false
initial concentration: 1.0
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006

metaM hdd2coa m
is: CHEBI:61526
name: trans-Hexadec-2-enoyl-CoA
constant: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: C05272
initial concentration: 1.0
is: HMDB03945
boundary condition: false

metaM lpam m
type: Species
is: HMDB00962
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:17460
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
name: lipoamide
constant: false
initial concentration: 1.0

metaM Tn antigen l
notes: FORMULA: C8H14NO5X CHARGE: 0
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: Tn antigen
constant: false
has only substance units: false
is: C04383

metaR DPCOAK
modifier: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: dephospho-CoA kinase
is version of: http://identifiers.org/ec-code/2.7.7.3
kinetic law: MODEL1310110026#
reversible: false
type: Reaction
product: MODEL1310110026#
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110026#

metaR RE2998M
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.3.3.6
name: RE2998
reversible: false
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110026#
is: SBO:0000176
fast: false
product: MODEL1310110026#
reactant: MODEL1310110026#

metaR biomass reaction
kinetic law: MODEL1310110026#
reversible: false
type: Reaction
name: biomass_reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
is described by: ECO:0000134
product: MODEL1310110026#
fast: false
reactant: MODEL1310110026#

metaR CYSO
name: cysteine oxidase
is: SBO:0000176
notes: GENE_ASSOCIATION: (1036.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES:IT
fast: false
kinetic law: MODEL1310110026#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.13.11.20
modifier: MODEL1310110026#
product: MODEL1310110026#
type: Reaction
reactant: MODEL1310110026#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110026#_260f517f_d696_4fd5_88a9_dce36d44b24c
is: C9JT23
is encoded by: hsa:126328
type: Species
name: NDUFA11
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110026#_2844c735_303c_4907_8522_35fd8dceb873
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
constant: false
is: P23921
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6240
name: RRM1

metaM 35cgmp c
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:57746
boundary condition: false
is: HMDB01314
is: SBO:0000247
name: 3',5'-cyclic GMP(1-)
notes: FORMULA: C10H11N5O7P CHARGE: -1 INCHI: InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/p-1/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00592 EHMN_ABBREVIATION: C00942
initial amount: NaN

metaR r0707
reversible: true
is: SBO:0000176
type: Reaction
product: MODEL1310110026#
fast: false
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.3.1.168
modifier: MODEL1310110026#
name: 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate phosphohydrolase (alkaline optimum) Folate biosynthesis EC:3.1.3.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1629.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777 NOTES:
reactant: MODEL1310110026#

metaM n2m2nmasn l
has only substance units: false
is: SBO:0000247
notes: FORMULA: C58H96N5O40X CHARGE: 0
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: C04946

metaM mmcoa R m
initial concentration: 1.0
type: Species
is: HMDB01269
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:57326
name: (R)-methylmalonyl-CoA(5-)
is: SBO:0000247
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_6fbcf69e_c36b_4b64_be84_1c1bdf7d1729
is: SBO:0000297
has part: P36957
type: Species
is encoded by: hsa:8050
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:1738
has part: Q02218
is encoded by: hsa:1743
has only substance units: false
initial amount: NaN
has part: P09622
has part: O00330
is encoded by: hsa:4967
name: DLD:DLST:OGDH:PDHX

http://identifiers.org/biomodels.db/MODEL1310110026#_89993467_88b1_4a22_8145_0076fb295edf
name: SLC6A7
constant: false
boundary condition: true
is encoded by: hsa:6534
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: Q99884
type: Species
has only substance units: false

metaR F6Tg
product: MODEL1310110026#
is: SBO:0000176
kinetic law: MODEL1310110026#
is described by: ECO:0000000
name: glycoprotein 6-alpha-L-fucosyltransferase
type: Reaction
fast: false
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.4.1.68
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (2530.4) or (2530.1) or (2530.3) or (2530.2) or (2530.5) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.68 Confidence Level: 0 AUTHORS: PMID:14514715 NOTES:NCD
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110026#_6bc0b97a_d558_4538_8187_21466dc07950
boundary condition: true
initial concentration: NaN
is encoded by: hsa:54344
name: DPM3:DPM1:DPM2
is encoded by: hsa:8818
constant: false
is: SBO:0000297
has part: Q9P2X0
initial amount: NaN
has only substance units: false
type: Species

metaR EX lac D LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-lactate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_07f82efc_dbe1_46d9_beed_b55e079cfaaf
constant: false
is: SBO:0000252
boundary condition: true
is: Q9UIG8
name: SLCO3A1
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:28232
type: Species
has only substance units: false

metaR H7MTer U
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110026#
modifier: MODEL1310110026#
product: MODEL1310110026#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (80235.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15208306 NOTES:NCD
name: H7 mannosyltransferase, endoplasmic reticulum
type: Reaction
kinetic law: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_2faa6b0b_085a_4e95_a99f_0a621c0bc83a
initial amount: NaN
is encoded by: hsa:4594
boundary condition: true
is: P22033
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
name: MUT

http://identifiers.org/biomodels.db/MODEL1310110026#_554e230e_7ebe_4960_bb27_56eaf6bdd890
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:400410
initial concentration: NaN
constant: false
is: SBO:0000252
is: Q9HBF5
has only substance units: false
name: ST20

metaR r0706
name: acyl-Coenzyme A dehydrogenase family, member 9 Bile acid biosynthesis EC:1.3.3.6
product: MODEL1310110026#
fast: false
kinetic law: MODEL1310110026#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (34.1) or (3712.1) or (R14373.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356170,PMID:8943006 NOTES:RE1814X
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.99.10
reactant: MODEL1310110026#
reversible: false
modifier: MODEL1310110026#

metaR FAOXC1811603m
type: Reaction
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110026#
reversible: false
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
fast: false
name: Beta oxidation fatty acid
is described by: ECO:0000269

metaR r1262
reactant: MODEL1310110026#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
fast: false
is: SBO:0000176
kinetic law: MODEL1310110026#
type: Reaction
product: MODEL1310110026#
reversible: false
name: EC:6.2.1.3

metaR RE3565C
reactant: MODEL1310110026#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110026#
product: MODEL1310110026#
is: SBO:0000176
fast: false
name: RE3565

metaR FAOXC16C16OHm
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16-->C16OH)m
type: Reaction

metaM tetdec2coa c
initial concentration: 1.0
boundary condition: false
is: HMDB02014
type: Species
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
name: tetradecadienoylcoa
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110026#_e933fa8e_e774_4b40_a0e4_ca6a79ce9830
is: SBO:0000252
type: Species
is encoded by: hsa:4126
is: O00462
initial amount: NaN
name: MANBA
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_f254885e_8bb6_4987_b83a_74eaf9e32e08
initial concentration: NaN
has only substance units: false
type: Species
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:11000
name: SLC27A3
initial amount: NaN
is: Q5K4L6

metaM c226coa c
is: C16169
boundary condition: false
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205479
type: Species
initial concentration: 1.0
name: cervonyl coenzyme A
is: SBO:0000247
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_96dca7da_08d9_4bd0_9dce_539e20786187
is: Q9BYZ2
is: SBO:0000252
is encoded by: hsa:92483
has only substance units: false
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
name: LDHAL6B
boundary condition: true

metaM 10fthf c
is: C00234
initial amount: NaN
type: Species
name: 10-Formyltetrahydrofolate
initial concentration: 1.0
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: HMDB00972
is: SBO:0000247
constant: false
is: CHEBI:57454
boundary condition: false
has only substance units: false

metaR S6T5g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110026#
type: Reaction
reversible: false
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110026#
is: SBO:0000176
modifier: MODEL1310110026#
fast: false
product: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_c72104b1_eef6_4847_93a5_6f8fa6971216
constant: false
initial concentration: NaN
is encoded by: hsa:6482
boundary condition: true
initial amount: NaN
has only substance units: false
name: ST3GAL1
is: SBO:0000252
type: Species

metaR UGALGTg
reactant: MODEL1310110026#
modifier: MODEL1310110026#
reversible: false
is: SBO:0000176
product: MODEL1310110026#
name: UDPgalactose:D-glucose 4-beta-D-galactosyltransferase, Golgi apparatus
kinetic law: MODEL1310110026#
fast: false
type: Reaction
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (3906.1) and (2683.1) or (8704.2) or (8704.1) SUBSYSTEM: Galactose metabolism EC Number: 2.4.1.22 Confidence Level: 4 AUTHORS: PMID:11419947 NOTES:NCD

metaR SBTD D2
fast: false
name: D-sorbitol dehydrogenase (D-fructose producing)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.14
reactant: MODEL1310110026#
reversible: false
notes: GENE_ASSOCIATION: (6652.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.14 Confidence Level: 0 AUTHORS: PMID:14965227 NOTES:NCD
modifier: MODEL1310110026#
product: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
is described by: ECO:0000000

metaM gar c
is: CHEBI:58457
is: HMDB02022
name: N1-(5-Phospho-D-ribosyl)glycinamide
notes: FORMULA: C7H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01190 EHMN_ABBREVIATION: C03838
has only substance units: false
initial concentration: 1.0
is: C03838
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false

metaM andrstrn r
constant: false
name: androsterone
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16032
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB00031
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_5978ad2a_15dd_4a35_a7e9_9ee831c804f6
constant: false
has only substance units: false
is: SBO:0000252
type: Species
name: _D29675_1_c
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:D29675

metaM thp2c x
is: HMDB12130
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:16987
type: Species
name: 1-piperideine-6-carboxylate
has only substance units: false
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
initial amount: NaN
boundary condition: false

metaM na1 r
boundary condition: false
name: sodium(1+)
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:29101
is: HMDB00588

metaM Tn antigen g
constant: false
notes: FORMULA: C8H14NO5X CHARGE: 0
has only substance units: false
name: Tn antigen
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: C04383
boundary condition: false

metaM ksi pre27 g
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C205H328N14O171S8X CHARGE: -9
type: Species
is: C00130
is: HMDB00175
has only substance units: false
initial concentration: 1.0
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 27

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

metaM ksi deg33 l
is: SBO:0000247
type: Species
notes: FORMULA: C76H125N5O62S2 CHARGE: -2
name: keratan sulfate I, degradation product 33
is: HMDB00143
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:12936
initial amount: NaN

metaM 3aib D c
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
constant: false
is: C03265
is: HMDB02299
name: D-3-Amino-isobutanoate
type: Species
initial amount: NaN

metaR ALAtN1
modifier: MODEL1310110026#
type: Reaction
is: SBO:0000185
reversible: true
fast: false
kinetic law: MODEL1310110026#
product: MODEL1310110026#
name: Alanine transport (Na, H coupled)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_38c50008_3df3_44bc_b746_7005ff8d883a
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:204
initial concentration: NaN
constant: false
boundary condition: true
name: AK2

metaM tyr L m
name: L-tyrosine
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
constant: false
initial concentration: 1.0
is: HMDB00158
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:17895
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_cb357a5b_f178_4595_ac13_e2ee17b48925
initial concentration: NaN
name: B3GALT5
constant: false
type: Species
is encoded by: hsa:10317
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_ec9ca2d2_7039_41d5_bf99_5ee4abbc8c38
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:221
has only substance units: false
name: ALDH3B1
type: Species
is: P43353
initial concentration: NaN
boundary condition: true
constant: false

metaM Asn X Ser Thr l
name: protein-linked asparagine residue (N-glycosylation site)
is: CHEBI:28938
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: XH CHARGE: 0
constant: false
is: SBO:0000247
is: HMDB00051
is: C01342
initial amount: NaN
has only substance units: false

metaR 3HCO3 NAt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
product: MODEL1310110026#
is: SBO:0000185
kinetic law: MODEL1310110026#
name: 3HCO3_NAt
reversible: true
type: Reaction
reactant: MODEL1310110026#
is described by: ECO:0000134
fast: false

http://identifiers.org/biomodels.db/MODEL1310110026#_b6835e0b_d157_4824_ab15_f77111897f11
is: SBO:0000252
is encoded by: hsa:23539
boundary condition: true
is: O95907
type: Species
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: SLC16A8

http://identifiers.org/biomodels.db/MODEL1310110026#_f17390b0_5d3f_45f5_946c_d089189b4737
is: Q13613
name: MTMR1
constant: false
is encoded by: hsa:8776
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species

metaR r1935
product: MODEL1310110026#
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
is: SBO:0000185
fast: false
reversible: false
type: Reaction
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110026#_f0852d20_91d5_43f3_aee9_de66b414a127
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:8622
is: O95263
type: Species
name: PDE8B
is: SBO:0000252
initial amount: NaN

metaR DECDICRNe
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of decadienoyl carnitine into the extra cellular space
type: Reaction

metaM hxan e
is: HMDB00157
has only substance units: false
boundary condition: false
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
name: hypoxanthine
is: SBO:0000247
is: CHEBI:17368
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110026#_1f44f076_90f1_42df_9a2d_6e606b003223
is: SBO:0000297
name: DBT:DLD:BCKDHA:BCKDHB
has part: Q9BQL0
is encoded by: hsa:594
initial amount: NaN
constant: false
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_f0ad55d0_4ba4_4697_aa54_dbe70009ab5b
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:8527
has only substance units: false
initial concentration: NaN
type: Species
is: Q16760
boundary condition: true
constant: false
name: DGKD

http://identifiers.org/biomodels.db/MODEL1310110026#_ed91f0bd_71f8_4b3b_ba33_c712e72975fd
is encoded by: hsa:AA614647
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
name: _AA614647_1_c
initial concentration: NaN
type: Species

metaM mev R c
is: HMDB00227
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
name: (R)-mevalonate
has only substance units: false
boundary condition: false
is: CHEBI:36464
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_258edd87_f635_4ee9_8462_659243e38ac5
initial concentration: NaN
constant: false
is encoded by: hsa:9197
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
name: SLC33A1
is: O00400

http://identifiers.org/biomodels.db/MODEL1310110026#_827ba2ad_442b_4a87_929c_ddeee0ba0561
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q8NCG5
has only substance units: false
is encoded by: hsa:10164
boundary condition: true
name: CHST4
type: Species

metaR P4507A1r
modifier: MODEL1310110026#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (1581.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.17 Confidence Level: 4 AUTHORS: NOTES:
name: cytochrome P450, family 7, subfamily A, polypeptide 1
is version of: http://identifiers.org/ec-code/1.14.13.17
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110026#
fast: false
product: MODEL1310110026#
kinetic law: MODEL1310110026#

metaM s2l2fn2m2masn l
initial concentration: 1.0
is: HMDB00174
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C90H145N6O65X CHARGE: -2
is: CHEBI:18287
type: Species
constant: false
name: PA6

metaM 3aib D e
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB02299
is: C03265
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
has only substance units: false
initial amount: NaN
type: Species
name: D-3-Amino-isobutanoate

http://identifiers.org/biomodels.db/MODEL1310110026#_fd9f9267_7502_4efd_9970_34242fad503d
has only substance units: false
initial concentration: NaN
name: MAN1C1
boundary condition: true
type: Species
constant: false
is: SBO:0000252
is: Q9NR34
initial amount: NaN
is encoded by: hsa:57134

metaR NDPK5n
kinetic law: MODEL1310110026#
fast: false
type: Reaction
reversible: true
product: MODEL1310110026#
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
reactant: MODEL1310110026#
is described by: ECO:0000304
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176

metaR GALASE12ly
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
fast: false
type: Reaction
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
is: SBO:0000176
product: MODEL1310110026#
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaM g3m8mpdol U r
boundary condition: false
type: Species
notes: FORMULA: C1905H3140N20O770P20 CHARGE: -20
initial amount: NaN
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: SBO:0000247
has only substance units: false
is: C05873
initial concentration: 1.0
constant: false

metaM pail45p hs c
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
is: CHEBI:28910
is: SBO:0000247
name: phosphatidylinositol 4,5-bisphosphate
constant: false
initial amount: NaN

metaR NOt
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
kinetic law: MODEL1310110026#
name: NO transport (diffusion)
product: MODEL1310110026#
is: SBO:0000185
reactant: MODEL1310110026#
fast: false
reversible: true

metaR LNLNCGt
reversible: true
is: SBO:0000185
reactant: MODEL1310110026#
fast: false
product: MODEL1310110026#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110026#
name: fatty acid transport via diffusion

metaM hxan c
is: HMDB00157
boundary condition: false
is: C00262
type: Species
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:17368
name: Hypoxanthine

metaM dad 2 c
is: CHEBI:17256
initial amount: NaN
constant: false
is: HMDB00101
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
initial concentration: 1.0
type: Species
has only substance units: false
name: 2-deoxyadenosine

metaM na1 e
initial amount: NaN
name: Sodium
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:4541
is: C01330
boundary condition: false
notes: FORMULA: Na CHARGE: 1
is: HMDB00588
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_34e5538d_934f_4371_bd4c_3147b5fea2e2
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
is: Q9H903
type: Species
name: MTHFD2L
is encoded by: hsa:441024
boundary condition: true
initial amount: NaN

metaR EX 34hpp
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_9425ba0b_7722_4719_a2a7_6ff2e31d6172
initial amount: NaN
constant: false
name: PIGO
boundary condition: true
is encoded by: hsa:84720
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM sgalside hs l
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
initial amount: NaN
constant: false
is: HMDB00904
type: Species
has only substance units: false
name: sulfatide galactocerebroside
boundary condition: false
is: CHEBI:16349

metaR AG13T13g
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is: SBO:0000176
modifier: MODEL1310110026#
type: Reaction
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

metaR 3SPYRSPm
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM
type: Reaction
name: 3-sulfinopyruvate hydrolase (spotaneous reaction), mitochondrial
fast: false
reversible: false
reactant: MODEL1310110026#
product: MODEL1310110026#
is described by: ECO:0000000
kinetic law: MODEL1310110026#

metaM 3mop m
is: CHEBI:28654
constant: false
name: 3-methyl-2-oxopentanoate
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
type: Species
is: HMDB00491
boundary condition: false

metaR r0892
reactant: MODEL1310110026#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.2.27
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:
type: Reaction
fast: false
modifier: MODEL1310110026#
name: Facilitated diffusion
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110026#
product: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_8cfc4e31_4f0b_48ae_9159_9906c76660f9
boundary condition: true
is: Q5TEK5
is encoded by: hsa:5142
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
name: PDE4B
initial concentration: NaN
constant: false

metaR RE3627M
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
modifier: MODEL1310110026#
reactant: MODEL1310110026#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110026#
reversible: true
name: RE3627
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:

metaM urate x
constant: false
is: CHEBI:17775
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
initial concentration: 1.0
initial amount: NaN
is: C00366
name: Urate
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
is: HMDB00289

http://identifiers.org/biomodels.db/MODEL1310110026#_38d4487e_77e1_4936_bace_bf41dc6f77fb
initial amount: NaN
type: Species
is: Q9NUD9
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: PIGV
constant: false
boundary condition: true
is encoded by: hsa:55650

metaM pi c
initial amount: NaN
is: HMDB00973
boundary condition: false
has only substance units: false
is: CHEBI:43474
type: Species
initial concentration: 1.0
notes: FORMULA: HO4P CHARGE: -2
name: hydrogenphosphate
constant: false
is: SBO:0000247
is: C00009

metaR DESAT16 2
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
is version of: http://identifiers.org/ec-code/1.14.19.1
product: MODEL1310110026#
is described by: ECO:0000000
type: Reaction
name: palmitoyl-CoA desaturase (n-C16:0CoA -> n-C16:1CoA)
is: SBO:0000176
reversible: false
fast: false

metaR UMPK5n
reversible: true
type: Reaction
is described by: ECO:0000269
fast: false
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
product: MODEL1310110026#
kinetic law: MODEL1310110026#
name: UMP kinase (dATP),nuclear

metaM acgalfucgalacglcgalgluside hs g
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
name: Type IA glycolipid
notes: FORMULA: C58H102N3O31FULLRCO CHARGE: 0
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:57847
is: HMDB00304

http://identifiers.org/biomodels.db/MODEL1310110026#_dfc404d0_6981_4b40_9869_2875d0a45ec1
name: SGPP2
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:130367
is: Q8IWX5
boundary condition: true
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_4dad7c57_8be9_4203_8552_ea6d930dbb15
is: SBO:0000252
is encoded by: hsa:60386
is: Q9HC21
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: SLC25A19
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_03a9473a_81a8_4893_89b2_95dfdb0be06e
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
name: _AI656480_1_m
boundary condition: true
is encoded by: hsa:AI656480
type: Species
initial amount: NaN

metaR DNDPt23m
is: SBO:0000185
fast: false
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110026#
type: Reaction
reversible: false
kinetic law: MODEL1310110026#
name: dTDP transport via dGTP antiport
modifier: MODEL1310110026#
is described by: ECO:0000269

metaR LEUKTRA4t
name: leukotriene A4 transport
reactant: MODEL1310110026#
fast: false
reversible: true
type: Reaction
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:
kinetic law: MODEL1310110026#
is described by: ECO:0000269
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110026#_feabf09c_91a8_451a_bd69_0cead9dcd0ec
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
name: PIK3R5
is: Q8WYR1
is encoded by: hsa:23533
is: SBO:0000252
initial concentration: NaN
type: Species

metaR AACOAT
reversible: true
type: Reaction
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/6.2.1.16
notes: GENE_ASSOCIATION: (65985.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.16 Confidence Level: 4 AUTHORS: PMID:12623130 NOTES:also EC 2.8.3.8 NCD
is: SBO:0000176
reactant: MODEL1310110026#
is described by: ECO:0000269
name: Acetoacetyl-CoA:acetate CoA-transferase
fast: false
kinetic law: MODEL1310110026#
product: MODEL1310110026#

metaM mal L e
is: CHEBI:15589
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
is: HMDB00156
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: (S)-malate(2-)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_5b8216af_7eae_4edf_9d0c_943a689cc65a
is: Q9ULD0
initial amount: NaN
name: OGDHL
has only substance units: false
is encoded by: hsa:55753
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110026#_eebd13ff_31f4_4472_8bea_564fe99446bc
is encoded by: hsa:570
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
constant: false
name: BAAT
initial amount: NaN
is: Q14032

http://identifiers.org/biomodels.db/MODEL1310110026#_7fc70dc5_8f4e_44ce_8148_5d0d9557f7d1
boundary condition: true
constant: false
is: P19440
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2678
name: GGT1

metaM hexccoa x
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: Hexacosanoyl-CoA (n-C26:0CoA)
constant: false
notes: FORMULA: C47H82N7O17P3S CHARGE: -4 INCHI: InChI=1/C47H86N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27-38(56)75-31-30-49-37(55)28-29-50-45(59)42(58)47(2,3)33-68-74(65,66)71-73(63,64)67-32-36-41(70-72(60,61)62)40(57)46(69-36)54-35-53-39-43(48)51-34-52-44(39)54/h34-36,40-42,46,57-58H,4-33H2,1-3H3,(H,49,55)(H,50,59)(H,63,64)(H,65,66)(H2,48,51,52)(H2,60,61,62)/p-4/t36-,40-,41-,42+,46-/m1/s1
is: HMDB06459
type: Species
boundary condition: false
initial concentration: 1.0

metaM nadp r
type: Species
is: CHEBI:58349
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide phosphate
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
is: C00006
boundary condition: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: HMDB00217

http://identifiers.org/biomodels.db/MODEL1310110026#_16c0739b_009c_43b1_8b52_eb1fec702821
boundary condition: true
name: PIGX:PIGM
has part: Q8TBF5
type: Species
constant: false
is encoded by: hsa:54965
is encoded by: hsa:93183
has part: Q9H3S5
has only substance units: false
is: SBO:0000297
initial amount: NaN
initial concentration: NaN

metaM s2l2fn2m2masn e
initial amount: NaN
type: Species
is: C00255
boundary condition: false
constant: false
is: HMDB00244
has only substance units: false
is: CHEBI:3554
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C90H145N6O65X CHARGE: -2
name: PA6

metaR LINKDEG2ly
reversible: false
product: MODEL1310110026#
kinetic law: MODEL1310110026#
is described by: ECO:0000000
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
name: degradation of proteoglycan linkage region, lysosomal
fast: false
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110026#_1d55d8a6_636f_4a73_aac1_d8ca0a4de20c
is encoded by: hsa:8560
has only substance units: false
name: DEGS1
is: SBO:0000252
initial amount: NaN
is: O15121
boundary condition: true
constant: false
type: Species
initial concentration: NaN

metaM pi e
boundary condition: false
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: CHEBI:43474
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
is: C00009
name: hydrogenphosphate
initial amount: NaN
is: HMDB00973

metaR r2338
kinetic law: MODEL1310110026#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
is: SBO:0000185
fast: false
product: MODEL1310110026#
reactant: MODEL1310110026#
reversible: true
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.19.1

metaR RE1522M
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
is: SBO:0000176
name: RE1522
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110026#
is described by: ECO:0000000
product: MODEL1310110026#

metaM phyt2ohcoa x
is: CHEBI:57334
is: HMDB01295
constant: false
notes: FORMULA: C41H70N7O18P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O18P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)32(50)40(54)70-20-19-43-30(49)17-18-44-38(53)35(52)41(6,7)22-63-69(60,61)66-68(58,59)62-21-29-34(65-67(55,56)57)33(51)39(64-29)48-24-47-31-36(42)45-23-46-37(31)48/h23-29,32-35,39,50-52H,8-22H2,1-7H3,(H,43,49)(H,44,53)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/p-4/t26?,27?,28?,29-,32?,33-,34-,35+,39-/m1/s1 EHMN_ABBREVIATION: C07343
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
name: 2-hydroxyphytanoyl-CoA(4-)
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_63779d52_da4a_4bfd_babc_ea4f7fca38e8
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
name: ALDOA
has only substance units: false
initial amount: NaN
is: P04075
is encoded by: hsa:226
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_d4f6f63a_5217_42c6_9772_62ea80336b32
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3636
name: INPPL1
constant: false
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is: O15357

http://identifiers.org/biomodels.db/MODEL1310110026#_5902851c_b3a0_488e_a7bf_817d0364cecf
is: P24752
initial amount: NaN
has only substance units: false
is encoded by: hsa:38
type: Species
name: ACAT1
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_28a5028b_e603_45da_a2ea_70df5d2a5af9
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:R51273
boundary condition: true
has only substance units: false
is: SBO:0000252
name: _R51273_1_c
constant: false
type: Species

metaR PHYHx
fast: false
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.14.11.18
kinetic law: MODEL1310110026#
type: Reaction
modifier: MODEL1310110026#
product: MODEL1310110026#
name: Phytanoyl-CoA dioxygenase, peroxisomal
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (5264.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.14.11.18 Confidence Level: 4 AUTHORS: PMID:8954107,PMID:9326940 NOTES:NJ
is described by: ECO:0000269

metaM glac r
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
is: HMDB06355
name: D-glucurono-6,3-lactone
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:18268
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_6e3cde19_de5d_41d1_8e5d_de1a30366d68
has only substance units: false
is: SBO:0000252
name: ATP5C1
is: Q6I9V2
is encoded by: hsa:509
boundary condition: true
constant: false
initial concentration: NaN
type: Species
initial amount: NaN

metaR S2L2FN2M2MASNtly
reactant: MODEL1310110026#
product: MODEL1310110026#
type: Reaction
name: s2l2fn2m2masn transport, extracellular to lysosome
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110026#
reversible: false
fast: false

metaR FUMSO3tm
type: Reaction
name: Fumarate:sulfite antiport, mitochondrial
is: SBO:0000185
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
fast: false
kinetic law: MODEL1310110026#

metaR PROSTGE2t2
modifier: MODEL1310110026#
reactant: MODEL1310110026#
product: MODEL1310110026#
reversible: true
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
kinetic law: MODEL1310110026#
is described by: ECO:0000269
fast: false
type: Reaction
name: prostaglandin uniport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110026#_77c93b53_4eea_427f_beac_4be4538191e0
is: O43181
type: Species
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:4724
is: SBO:0000252
has only substance units: false
name: NDUFS4
initial concentration: NaN

metaM lnlncg e
type: Species
name: gamma-linolenate
initial concentration: 1.0
constant: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
is: CHEBI:32391
is: HMDB03073
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaR DAGt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.1.107 Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000269
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110026#
fast: false
type: Reaction
product: MODEL1310110026#
name: diacylglycerol transport
reactant: MODEL1310110026#

metaM CE2431 m
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
boundary condition: false
name: cis-deca-4-enoyl-CoA
type: Species
constant: false
is: SBO:0000247
is: CHEBI:57795
initial amount: NaN

metaM ac m
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:30089
boundary condition: false
is: HMDB00042
constant: false
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
initial amount: NaN
type: Species
name: acetate

metaR BDHm
modifier: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
product: MODEL1310110026#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.30
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT

metaR TRDR
type: Reaction
is version of: http://identifiers.org/ec-code/1.8.1.9
reactant: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
modifier: MODEL1310110026#
is described by: ECO:0000269
product: MODEL1310110026#
reversible: false
name: thioredoxin reductase (NADPH)
kinetic law: MODEL1310110026#
is: SBO:0000176

metaR MAL Lte
is described by: ECO:0000134
reactant: MODEL1310110026#
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of L-malate

metaR PNTEH
modifier: MODEL1310110026#
fast: false
type: Reaction
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110026#
is: SBO:0000176
name: Hydrolase Class ( RXN R02973)
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.5.1.92
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) SUBSYSTEM: CoA catabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10567687,PMID:11491533 NOTES:EC 3.5.1- KEGG RXN R02973 RM
reactant: MODEL1310110026#

metaR S6T3g
modifier: MODEL1310110026#
reversible: false
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110026#
reactant: MODEL1310110026#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.8.2.21
kinetic law: MODEL1310110026#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.8.2.17

http://identifiers.org/biomodels.db/MODEL1310110026#_1a91b1cc_e29f_4cdd_b41d_789fae1419c8
constant: false
is: E9PHN8
is encoded by: hsa:9843
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
name: HEPH
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110026#_878d0a75_75a3_459f_abd5_edde0c5b7fdb
boundary condition: true
name: GALE
is encoded by: hsa:2582
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
is: Q14376
initial concentration: NaN
constant: false

metaM gullac r
has only substance units: false
is: CHEBI:17587
is: SBO:0000247
boundary condition: false
type: Species
name: L-gulono-1,4-lactone
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H10O6 CHARGE: 0 INCHI: InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3+,4-,5+/m0/s1
is: HMDB03466

http://identifiers.org/biomodels.db/MODEL1310110026#_7b2bc8dd_c189_4b97_ac3f_3fc8c11d6e01
name: EGFL8
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
type: Species
is: Q99944
is encoded by: hsa:80864

metaR FUMAC
name: fumarylacetoacetase
notes: GENE_ASSOCIATION: (2184.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.7.1.2 Confidence Level: 4 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/3.7.1.2
is: SBO:0000176
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
reversible: false
product: MODEL1310110026#
type: Reaction
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110026#_d2f300c2_5cef_421c_b1bd_2ca77359272b
name: PDE6C
is encoded by: hsa:5146
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
is: P51160
boundary condition: true
constant: false

metaR RE3568C
type: Reaction
product: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reversible: true
name: RE3568
is: SBO:0000176
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
is described by: ECO:0000000

metaM tdchola e
is: HMDB00951
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
is: CHEBI:9407
name: taurochenodeoxycholate
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_77bff5f5_d2e0_4483_b270_39050e2072d3
name: SLC34A1
constant: false
initial amount: NaN
is: SBO:0000252
is: Q7Z725
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:6569

metaM h n
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:24636
boundary condition: false
name: proton
type: Species
initial concentration: 1.0
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: SBO:0000247

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

metaR LCTStg
type: Reaction
is described by: ECO:0000000
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:this reaciton is only found in lactating mammary cells NCD
kinetic law: MODEL1310110026#
reversible: false
reactant: MODEL1310110026#
fast: false
name: lactose transport from Golgi to extracellular (via vesicle)
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110026#_7d76afae_d154_454e_b27d_78b95acf9d42
boundary condition: true
is encoded by: hsa:6514
is: P11168
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
name: SLC2A2
has only substance units: false

metaR GLNt4
reactant: MODEL1310110026#
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
name: L-glutamine reversible transport via sodium symport
product: MODEL1310110026#
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:SAB

metaR 2OXOADOXm
reactant: MODEL1310110026#
type: Reaction
notes: GENE_ASSOCIATION: (4967.1) and (1738.1 and 8050.1) and (1743.1) or (4967.2) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Lysine metabolism EC Number: 2.3.1.61 Confidence Level: 2 AUTHORS: NOTES:SAB
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) (mitochondria)
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.8.1.4
reversible: false
is described by: ECO:0000304
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.2.4.2
is version of: http://identifiers.org/ec-code/2.3.1.61
modifier: MODEL1310110026#
is: SBO:0000176
fast: false

metaR S6T14g
modifier: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110026#
is described by: ECO:0000000
is: SBO:0000176

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

metaM leu L m
is: CHEBI:15603
boundary condition: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
name: L-leucine
has only substance units: false
initial concentration: 1.0
is: HMDB00687

metaM acac m
name: acetoacetate
initial amount: NaN
is: CHEBI:13705
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB00060
type: Species
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164

metaR r1540
is described by: ECO:0000000
modifier: MODEL1310110026#
reversible: false
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.17.4.1
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
is: SBO:0000185
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
product: MODEL1310110026#

metaM ksii core4 pre9 g
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28067
notes: FORMULA: C83H133N7O64S2X CHARGE: -3
boundary condition: false
type: Species
name: keratan sulfate II biosynthesis, precursor 9
has only substance units: false
constant: false

metaR FAOXC226
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
type: Reaction
modifier: MODEL1310110026#
is: SBO:0000176
product: MODEL1310110026#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110026#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110026#
name: Beta oxidation of long chain fatty acid

metaM man r
initial concentration: 1.0
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB00169
name: D-mannose
is: CHEBI:16024
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_4f6d8b65_c683_4e76_ae80_a0c2c0aff79e
boundary condition: true
type: Species
constant: false
initial amount: NaN
is: Q9UEF7
initial concentration: NaN
is encoded by: hsa:9365
is: SBO:0000252
name: KL
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_79aee03c_0341_4f24_80ca_ec4476ec1560
type: Species
has only substance units: false
is encoded by: hsa:154091
name: SLC2A12
is: SBO:0000252
is: Q8TD20
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN

metaM gam e
constant: false
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
name: D-Glucosamine
initial amount: NaN
is: CHEBI:17315
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: C00329
has only substance units: false
is: HMDB01514

http://identifiers.org/biomodels.db/MODEL1310110026#_041fa063_d145_4aca_bd27_da6ea1aeabb6
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:8818
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
name: DPM2

metaM tdchola c
is: HMDB00951
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
type: Species
has only substance units: false
name: taurochenodeoxycholate
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:9407

http://identifiers.org/biomodels.db/MODEL1310110026#_50da9008_6e72_48a2_a694_c6524d771e6e
boundary condition: true
name: GGH
is encoded by: hsa:8836
constant: false
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
is: Q92820

metaM adp n
is: SBO:0000247
initial concentration: 1.0
is: HMDB01341
boundary condition: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
type: Species
initial amount: NaN
is: CHEBI:456216
has only substance units: false
name: ADP(3-)
constant: false

metaR FACOAL80i
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (2181.1) or (2181.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: NOTES:JLR Also 6.2.1.3
reactant: MODEL1310110026#
name: fatty-acid--CoA ligase (octanoate)
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
product: MODEL1310110026#

metaR SUBERCACT
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberyl carnitine into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_b33cd411_3a9c_404c_bde3_95ca2627bad9
is encoded by: hsa:2983
name: GUCY1A2:GUCY1B3
constant: false
is encoded by: hsa:2977
has part: P33402
type: Species
initial amount: NaN
has part: Q02153
boundary condition: true
is: SBO:0000297
initial concentration: NaN
has only substance units: false

metaM h l
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: C00080
initial amount: NaN
type: Species
has only substance units: false
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: "
name: proton
is: http://identifiers.org/pubchem.compound/3380
is: CHEBI:24636

http://identifiers.org/biomodels.db/MODEL1310110026#_265e9885_5c10_472c_9dbb_b6654560e402
is encoded by: hsa:5293
name: PIK3CD:PIK3R3
has only substance units: false
is: SBO:0000297
is encoded by: hsa:8503
type: Species
constant: false
boundary condition: true
has part: A7E2E0
initial concentration: NaN
initial amount: NaN
has part: Q92569

metaM HC02210 c
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
name: prostaglandin-d3
is: CHEBI:34939
type: Species
has only substance units: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
is: SBO:0000247

metaR C142CPT1
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tetradecadienoylcarnitine
type: Reaction

metaM CE2838 e
name: maltononaose
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5041
is: C01936
type: Species
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838

metaM h m
is: C00080
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:24636
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
name: proton
boundary condition: false
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/3380

metaM adp m
initial concentration: 1.0
type: Species
has only substance units: false
is: C00008
initial amount: NaN
is: CHEBI:456216
boundary condition: false
name: ADP
is: http://identifiers.org/pubchem.compound/3310
is: HMDB01341
constant: false
is: SBO:0000247

metaM eicostetcoa c
type: Species
is: C16164
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
name: eicosatetranoyl coenzyme A

metaR r1777
product: MODEL1310110026#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110026#
fast: false
reversible: false
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110026#
is described by: ECO:0000000
reactant: MODEL1310110026#

metaR GPIDAer
name: glycophosphatidylinositol (GPI) deacylase, endoplasmic reticulum
product: MODEL1310110026#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (80055.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14734546 NOTES:NCD
reactant: MODEL1310110026#
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
is: SBO:0000176
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_ba90964c_f4bb_4a04_b936_e69222ead328
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI971036
constant: false
name: _AI971036_1_x
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_d9ff61a0_cdb1_4d2e_b556_8c995dd7108f
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
name: _AI934540_1_c
is encoded by: hsa:AI934540
boundary condition: true
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_23692417_d3cb_4ca1_8294_f2ae75265f46
boundary condition: true
type: Species
is: SBO:0000252
name: SLC26A2
initial concentration: NaN
is: P50443
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:1836

metaM gam c
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
name: D-Glucosamine
constant: false
boundary condition: false
is: CHEBI:17315
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: C00329
is: HMDB01514

metaM 5forthf c
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:57456
is: C00664
constant: false
is: HMDB01534
name: 5-Formiminotetrahydrofolate
notes: FORMULA: C20H22N8O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00483 EHMN_ABBREVIATION: C00664

http://identifiers.org/biomodels.db/MODEL1310110026#_2d0fbae5_5f84_404a_8333_f17a301dc2e6
is encoded by: hsa:3423
is: SBO:0000252
is: B4DGD7
name: IDS
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species

metaR EX eicostet LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: eicosatetranoic acid exchange
type: Reaction

metaR FACOAL161
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110026#
reversible: true
reactant: MODEL1310110026#
is: SBO:0000176
fast: false
product: MODEL1310110026#
modifier: MODEL1310110026#
is described by: ECO:0000000
name: fatty-acid--CoA ligase (hexadecenoate)
is version of: http://identifiers.org/ec-code/6.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110026#_43b758c7_ac71_4b38_a941_02b3f095968e
is: SBO:0000252
type: Species
name: _AI818585_1_c
is encoded by: hsa:AI818585
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false

metaR HIStN1
fast: false
kinetic law: MODEL1310110026#
reversible: true
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
product: MODEL1310110026#
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110026#
name: Histidine transport (Na, H coupled)
modifier: MODEL1310110026#

metaM ksii core4 deg2 l
has only substance units: false
is: HMDB00143
initial concentration: 1.0
constant: false
initial amount: NaN
name: keratan sulfate II (core 4-linked), degradation product 2
is: CHEBI:12936
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C78H127N6O61S2X CHARGE: -2

metaR LTD4DP
reactant: MODEL1310110026#
name: Leukotriene D4 dipeptidase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
type: Reaction
kinetic law: MODEL1310110026#
product: MODEL1310110026#
fast: false
reversible: true
is: SBO:0000176

metaM adpcoa c
constant: false
initial concentration: 1.0
is: C14143
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB04047
initial amount: NaN
name: adipoylcoa
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
type: Species

metaM acglcgalgluside hs g
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
name: N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:17103
notes: FORMULA: C38H69N2O17FULLRCO CHARGE: 0

metaM thf m
constant: false
is: HMDB01846
initial concentration: 1.0
is: C00101
is: CHEBI:57453
has only substance units: false
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
initial amount: NaN
is: SBO:0000247
name: 5,6,7,8-Tetrahydrofolate
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110026#_d38145cf_6cc1_455f_9c87_5293c9df5afe
type: Species
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: GMPR2
is encoded by: hsa:51292
initial concentration: NaN
has only substance units: false

metaM omhpal r
is: SBO:0000247
notes: FORMULA: C16H30O3 CHARGE: -1
has only substance units: false
type: Species
boundary condition: false
is: HMDB06294
initial amount: NaN
name: w-hydroxypalmiticacid
constant: false
initial concentration: 1.0

metaM pail hs n
is: CHEBI:57880
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol(1-)

metaR RE1709N
is version of: http://identifiers.org/ec-code/4.2.1.96
is: SBO:0000176
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: true
name: RE1709
fast: false
reactant: MODEL1310110026#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110026#

metaR r1544
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110026#
is: SBO:0000185
type: Reaction
product: MODEL1310110026#
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
is described by: ECO:0000000

metaR EX 3hexdcrn
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyhexadecanoyl carnitine
type: Reaction

metaR EBP1r
name: 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase
type: Reaction
reactant: MODEL1310110026#
is described by: ECO:0000134
reversible: false
fast: false
notes: GENE_ASSOCIATION: (10682.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 4 AUTHORS: PMID:10391219 NOTES:involved in lanosterol -> cholesterol pathway NJ
is version of: http://identifiers.org/ec-code/5.3.3.5
is: SBO:0000176
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
product: MODEL1310110026#

metaR CYTK14n
type: Reaction
modifier: MODEL1310110026#
name: cytidylate kinase (dCMP,CTP),nuclear
reversible: true
fast: false
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14

http://identifiers.org/biomodels.db/MODEL1310110026#_592ec5ec_75f9_4d8e_be9b_36b67e9146d9
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:23530
name: NNT
has only substance units: false

metaM h2o x
initial concentration: 1.0
name: H2O
is: CHEBI:15377
boundary condition: false
is: C00001
has only substance units: false
constant: false
is: HMDB02111
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001

metaR r2198
reversible: true
type: Reaction
reactant: MODEL1310110026#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110026#
kinetic law: MODEL1310110026#
is: SBO:0000185
fast: false
modifier: MODEL1310110026#

metaR r1434
reactant: MODEL1310110026#
is: SBO:0000185
product: MODEL1310110026#
is described by: ECO:0000000
kinetic law: MODEL1310110026#
reversible: false
type: Reaction
name: Transport reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:

metaM pram c
name: 5-Phospho-beta-D-ribosylamine
initial concentration: 1.0
boundary condition: false
is: HMDB01128
is: SBO:0000247
is: C03090
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: CHEBI:58681
notes: FORMULA: C5H11NO7P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01053 EHMN_ABBREVIATION: C03090

http://identifiers.org/biomodels.db/MODEL1310110026#_6f459846_b201_43d3_8e55_98858ba30e2c
has only substance units: false
boundary condition: true
is: SBO:0000252
name: GAPDH
initial concentration: NaN
is encoded by: hsa:2597
initial amount: NaN
constant: false
is: E7EUT4
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_f8e61a87_3e9c_4453_b1be_734ec9d7ed86
type: Species
initial amount: NaN
name: SLC2A7
initial concentration: NaN
is: Q6PXP3
boundary condition: true
constant: false
is encoded by: hsa:155184
is: SBO:0000252
has only substance units: false

metaR PPCOAOm
notes: GENE_ASSOCIATION: (80724.1) or (27034.1) or (36.1) or (35.1) or (84129.1) or (34.1) or (28976.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:12359132,PMID:12359260,PMID:15560374,PMID:2565344,PMID:3035565,PMID:7698750,PMID:8276399 NOTES:NCD
name: Propanoyl-CoA:FAD 2,3-oxidoreductase, mitochondrial
fast: false
reversible: false
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110026#
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
kinetic law: MODEL1310110026#

metaM h x
name: proton
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
type: Species
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/3380
is: CHEBI:24636
is: C00080
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaM sucsal m
boundary condition: false
is: CHEBI:57706
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB01259
type: Species
constant: false
name: Succinic semialdehyde
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
initial amount: NaN

metaM CE2418 m
is: HMDB11123
constant: false
type: Species
has only substance units: false
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
is: CHEBI:28387
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaM leu L c
is: CHEBI:15603
constant: false
name: L-leucine
is: HMDB00687
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species

metaR r1547
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110026#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110026#
fast: false

metaR r1622
fast: false
reversible: true
reactant: MODEL1310110026#
is: SBO:0000185
product: MODEL1310110026#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110026#
is described by: ECO:0000000

metaM c4dc c
boundary condition: false
notes: FORMULA: C11H18NO6 CHARGE: -1
name: succinyl carnitine
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/213144
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: C02862
is: HMDB02013

metaM adp r
constant: false
name: ADP(3-)
has only substance units: false
boundary condition: false
is: CHEBI:456216
is: HMDB01341
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
type: Species

metaR r2199
fast: false
kinetic law: MODEL1310110026#
type: Reaction
modifier: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
product: MODEL1310110026#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reversible: true

metaR PROD2m
modifier: MODEL1310110026#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.5.99.8
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR SAB m
name: Proline dehydrogenase (m)
is described by: ECO:0000254
type: Reaction
fast: false
reactant: MODEL1310110026#
product: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_2cdf6d29_50cf_48d4_94d3_1d50c4de8a7f
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:23475
initial amount: NaN
type: Species
is: Q15274
is: SBO:0000252
name: QPRT

http://identifiers.org/biomodels.db/MODEL1310110026#_6a9af561_0ee2_4d6f_8519_d8997e8690ea
is: SBO:0000252
initial concentration: NaN
name: CPT1B
is: Q53FV7
initial amount: NaN
is encoded by: hsa:1375
has only substance units: false
boundary condition: true
type: Species
constant: false

metaR GLNtN1
modifier: MODEL1310110026#
product: MODEL1310110026#
is: SBO:0000185
kinetic law: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
reactant: MODEL1310110026#
name: Glutamine transport (Na, H coupled)
is described by: ECO:0000269
type: Reaction
reversible: true

metaR r1546
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110026#
is: SBO:0000185
fast: false
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110026#
reversible: true

metaR r1433
reversible: false
name: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9
fast: false
is described by: ECO:0000000
reactant: MODEL1310110026#
is: SBO:0000176
type: Reaction
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
kinetic law: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_5cc22cf8_e813_44ce_8990_725ea65e680d
has only substance units: false
is encoded by: hsa:8836
initial concentration: NaN
name: GGH
initial amount: NaN
constant: false
is: Q92820
type: Species
boundary condition: true
is: SBO:0000252

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_94006437_1c9e_4050_85d7_33a673b17b42
constant: false
has only substance units: false
is encoded by: hsa:79071
type: Species
boundary condition: true
is: Q9H5J4
name: ELOVL6
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR EX prostgi2 LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin I2(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_b5d7a168_0caf_4ebb_8e16_c0480452b297
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:8875
has only substance units: false
is encoded by: hsa:8876
initial concentration: NaN
has part: A8K7W0
name: VNN3:VNN2:VNN1
is encoded by: hsa:55350
has part: O95497
boundary condition: true
is: SBO:0000297

metaM cholcoa c
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
name: choloyl-CoA(4-)
is: CHEBI:57373
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB01374

metaR PROD2
is described by: ECO:0000254
reactant: MODEL1310110026#
name: Proline dehydrogenase
is: SBO:0000176
product: MODEL1310110026#
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (58510.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR
fast: false
is version of: http://identifiers.org/ec-code/1.5.99.8
type: Reaction
reversible: false
kinetic law: MODEL1310110026#

metaR r1621
type: Reaction
modifier: MODEL1310110026#
product: MODEL1310110026#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110026#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110026#

metaM glyc S c
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:33871
is: HMDB06372
name: (S)-Glycerate
type: Species
notes: FORMULA: C3H5O4 CHARGE: 0
is: SBO:0000247

metaM accoa g
type: Species
constant: false
name: acetyl-CoA(4-)
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: SBO:0000247
is: HMDB01206
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:57288

metaM cholate r
is: SBO:0000247
boundary condition: false
is: HMDB00619
name: cholate
constant: false
initial amount: NaN
is: CHEBI:29747
notes: FORMULA: C24H39O5 CHARGE: -1 INCHI: InChI=1S/C24H40O5/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29)/p-1/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
type: Species
has only substance units: false
initial concentration: 1.0

metaM man e
is: C00159
is: HMDB00169
has only substance units: false
boundary condition: false
is: CHEBI:16024
is: SBO:0000247
name: D-Mannose
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN

metaR NMNATr
modifier: MODEL1310110026#
fast: false
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reversible: true
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: nicotinamide-nucleotide adenylyltransferase
is version of: http://identifiers.org/ec-code/2.7.7.1
reactant: MODEL1310110026#

metaM mn l
is: SBO:0000247
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1
is: HMDB06535
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
name: beta-1,4-mannose-N-acetylglucosamine
type: Species
boundary condition: false

metaM zymst r
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437
boundary condition: false
has only substance units: false
constant: false
is: HMDB06271
initial amount: NaN
type: Species
initial concentration: 1.0
name: zymosterol
is: CHEBI:18252
is: SBO:0000247

metaR CYTK2
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110026#
name: cytidylate kinase (dCMP)
modifier: MODEL1310110026#
is described by: ECO:0000269
fast: false
type: Reaction
kinetic law: MODEL1310110026#
reversible: true
is: SBO:0000176
reactant: MODEL1310110026#

metaR DURAD
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.2
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
product: MODEL1310110026#
name: dihydrouracil dehydrogenase (NADP)
reversible: true
fast: false
is described by: ECO:0000269
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109

metaR r1549
reactant: MODEL1310110026#
type: Reaction
product: MODEL1310110026#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
kinetic law: MODEL1310110026#
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110026#_77d60d9a_d52f_4eb8_8870_add111e2c93c
has only substance units: false
is: Q86U05
constant: false
type: Species
initial amount: NaN
name: SLC7A8
is encoded by: hsa:23428
is: SBO:0000252
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_30cef57b_4e51_4091_9a68_36a0505807ab
initial amount: NaN
name: PFKL:PFKP
boundary condition: true
constant: false
initial concentration: NaN
type: Species
has only substance units: false
has part: Q7L2M7
is: SBO:0000297
is encoded by: hsa:5211

http://identifiers.org/biomodels.db/MODEL1310110026#_5f71111a_f57a_455e_bb3b_1a5801699079
initial amount: NaN
type: Species
boundary condition: true
name: DGUOK
constant: false
initial concentration: NaN
is: E5KSL6
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1716

http://identifiers.org/biomodels.db/MODEL1310110026#_ff83a19b_3913_41a5_84e4_91ef36bb58b4
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: GALNT10
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:55568

metaR CITRtm
reversible: true
modifier: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
name: citrulline mitochondrial transport via proton antiport
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
product: MODEL1310110026#

metaR r0245
kinetic law: MODEL1310110026#
product: MODEL1310110026#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110026#
fast: false
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.3
modifier: MODEL1310110026#

metaR r1620
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110026#
reactant: MODEL1310110026#
modifier: MODEL1310110026#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110026#
is described by: ECO:0000000
reversible: true

metaR CLPNDt
product: MODEL1310110026#
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
name: fatty acid transport via diffusion
kinetic law: MODEL1310110026#
reversible: true

metaR CYTK1
name: cytidylate kinase (CMP)
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110026#
product: MODEL1310110026#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
reactant: MODEL1310110026#
modifier: MODEL1310110026#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110026#_0f6ea656_748e_44e4_9696_d60909fb37c2
is: P28331
is encoded by: hsa:4719
initial amount: NaN
boundary condition: true
name: NDUFS1
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is: SBO:0000252

metaR r1435
kinetic law: MODEL1310110026#
reversible: false
is described by: ECO:0000000
fast: false
name: Transport reaction
reactant: MODEL1310110026#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
type: Reaction
product: MODEL1310110026#

metaM leu L e
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15603
is: HMDB00687
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
constant: false
initial amount: NaN
type: Species
name: L-leucine

http://identifiers.org/biomodels.db/MODEL1310110026#_04b61450_a4f0_45ea_b3b3_4aa951fa5baa
name: DGKD
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:8527
initial concentration: NaN
type: Species

metaR r1548
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110026#
product: MODEL1310110026#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110026#

metaM glyc S e
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:33871
is: HMDB06372
constant: false
name: (S)-Glycerate
boundary condition: false
has only substance units: false
notes: FORMULA: C3H5O4 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110026#_2d83a295_c2d3_4def_8c8c_e2be81faa999
type: Species
is encoded by: hsa:8611
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: PPAP2A
has only substance units: false
is: G3XA95

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

metaR CYTK7n
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP,UTP),nuclear
reversible: true
fast: false
product: MODEL1310110026#
type: Reaction
modifier: MODEL1310110026#
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR r0246
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
kinetic law: MODEL1310110026#
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.5.1.3
modifier: MODEL1310110026#
reversible: false
is: SBO:0000176
reactant: MODEL1310110026#
fast: false
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2

metaM 3sala c
name: 3-Sulfino-L-alanine
has only substance units: false
is: CHEBI:61085
initial concentration: 1.0
type: Species
is: C00606
notes: FORMULA: C3H5NO4S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247

metaM man g
is: HMDB00169
type: Species
name: D-mannose
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: CHEBI:16024
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false

metaR CYTK4
is: SBO:0000176
reactant: MODEL1310110026#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
modifier: MODEL1310110026#
fast: false
name: cytidylate kinase (dCMP)(GTP)
product: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.7.4.3
reversible: true

metaR r1626
kinetic law: MODEL1310110026#
reversible: true
fast: false
product: MODEL1310110026#
is described by: ECO:0000000
reactant: MODEL1310110026#
is: SBO:0000185
modifier: MODEL1310110026#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR CYANtm
reactant: MODEL1310110026#
fast: false
product: MODEL1310110026#
is described by: ECO:0000000
kinetic law: MODEL1310110026#
name: Cyanide transport via diffusion (mitochondrial)
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:assumed to be readily diffusible MM
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110026#_6fd2b7af_192b_469e_8443_075b13632bc8
is: Q9H3H5
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
name: DPAGT1
is encoded by: hsa:1798
boundary condition: true
initial amount: NaN

metaM malthx e
initial amount: NaN
initial concentration: 1.0
type: Species
name: Maltohexaose
constant: false
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
has only substance units: false
is: http://identifiers.org/pubchem.compound/5041
is: C01936
is: SBO:0000247
boundary condition: false

metaM thbpt4acam n
constant: false
is: CHEBI:15374
boundary condition: false
name: 4a-hydroxytetrahydrobiopterin
initial amount: NaN
is: HMDB02281
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_48f15462_1d36_45ee_b564_02ea546c7b3a
is: P07686
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:3074
initial concentration: NaN
name: HEXB
type: Species
boundary condition: true

metaM HC02213 e
constant: false
has only substance units: false
name: prostaglandin-e3
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:28031
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
initial amount: NaN
initial concentration: 1.0

metaM CE2422 m
initial amount: NaN
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA
boundary condition: false
type: Species
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
has only substance units: false
is: CHEBI:28387
initial concentration: 1.0
is: HMDB11123
is: SBO:0000247
constant: false

metaR CYTK3
is version of: http://identifiers.org/ec-code/2.7.4.3
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
reactant: MODEL1310110026#
type: Reaction
name: cytidylate kinase (CMP)(GTP)
is described by: ECO:0000269
reversible: true
product: MODEL1310110026#
fast: false
kinetic law: MODEL1310110026#
is: SBO:0000176
modifier: MODEL1310110026#

metaR RE1709C
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
fast: false
type: Reaction
is described by: ECO:0000000
name: RE1709
reactant: MODEL1310110026#
is: SBO:0000176
product: MODEL1310110026#
kinetic law: MODEL1310110026#

metaR NCNt
name: Na+/Ca2+-NH4+ exchange
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000269
reversible: true
product: MODEL1310110026#
fast: false
modifier: MODEL1310110026#
type: Reaction

metaR r1625
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
is described by: ECO:0000000
product: MODEL1310110026#
type: Reaction
fast: false
reactant: MODEL1310110026#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM tchola x
type: Species
name: taurocholate
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C26H45NO7S CHARGE: 0 INCHI: InChI=1S/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
is: CHEBI:36257
constant: false
is: SBO:0000247
is: HMDB00036

metaR S2L2N2M2MASNtly
reversible: false
product: MODEL1310110026#
name: s2l2n2m2masn transport, extracellular to lysosome
is described by: ECO:0000000
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110026#
type: Reaction
is: SBO:0000185
fast: false

metaM accoa c
has only substance units: false
type: Species
is: CHEBI:57288
initial amount: NaN
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: SBO:0000247
is: HMDB01206
constant: false
initial concentration: 1.0
is: C00024
boundary condition: false
name: Acetyl-CoA

metaR S6TASE8ly
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110026#
fast: false
kinetic law: MODEL1310110026#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: true
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.1.6.4
name: N-acetylgalactosamine-6-sulfatase, lysosomal
product: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_7e3a2b59_098e_44d2_848f_3553148083fe
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:9162
name: DGKI
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is: O75912

metaR HISCAT1
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_51687bfe_6f80_426b_8f5c_8db17df1a56b
is encoded by: hsa:10599
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
is: Q9Y6L6
name: SLCO1B1
initial amount: NaN

metaM h r
type: Species
is: http://identifiers.org/pubchem.compound/3380
initial amount: NaN
is: CHEBI:24636
is: C00080
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial concentration: 1.0
has only substance units: false
name: proton

metaR r0027
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
kinetic law: MODEL1310110026#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.39
modifier: MODEL1310110026#
reversible: true
fast: false
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
product: MODEL1310110026#
type: Reaction

metaR r1624
reversible: true
product: MODEL1310110026#
fast: false
modifier: MODEL1310110026#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
type: Reaction

metaM mescoa m
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
is: C06028
is: CHEBI:27969
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
name: Mesaconyl-CoA
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR ACHtn
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
reversible: true
product: MODEL1310110026#
type: Reaction
name: Acetylcholin transport, nuclear trhough pores
is: SBO:0000185
fast: false
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#

metaM h2o r
is: CHEBI:15377
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
name: H2O
is: C00001
is: HMDB02111
has only substance units: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
boundary condition: false
initial amount: NaN

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaR DMATTx
modifier: MODEL1310110026#
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.5.1.1
fast: false
reversible: false
product: MODEL1310110026#
is described by: ECO:0000134
name: dimethylallyltranstransferase
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
kinetic law: MODEL1310110026#

metaM man l
boundary condition: false
is: HMDB00169
initial concentration: 1.0
is: CHEBI:16024
has only substance units: false
name: D-mannose
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: SBO:0000247
initial amount: NaN
constant: false
type: Species

metaR CYTK7
reactant: MODEL1310110026#
type: Reaction
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
is described by: ECO:0000269
name: cytidylate kinase (CMP,UTP)
fast: false
reversible: true
is: SBO:0000176
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM dtdp m
is: C00363
is: HMDB01274
is: CHEBI:58369
has only substance units: false
constant: false
name: dTDP
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaM HC02213 c
initial amount: NaN
name: prostaglandin-e3
constant: false
boundary condition: false
type: Species
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28031
has only substance units: false

metaR r1431
fast: false
reactant: MODEL1310110026#
is described by: ECO:0000000
kinetic law: MODEL1310110026#
name: 2-Deoxyuridine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Pyrimidine metabolism EC:1.17.4.1
reversible: false
product: MODEL1310110026#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:

metaR PVD3
is: SBO:0000176
name: Previtamin D3 formation
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:6281884 NOTES:This reaction takes place in skin and needs UV 290-305. based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
reversible: true
product: MODEL1310110026#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_40476634_6bff_49c9_b795_0f8d09fd63de
is: SBO:0000252
is encoded by: hsa:38
is: P24752
boundary condition: true
initial amount: NaN
name: ACAT1
constant: false
type: Species
initial concentration: NaN
has only substance units: false

metaM 2mb2coa m
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
type: Species
initial amount: NaN
boundary condition: false
is: HMDB02054
name: 2-methylcrotonoyl-CoA(4-)
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57337
has only substance units: false

metaR CYTK5
name: cytidylate kinase (dCMP)
modifier: MODEL1310110026#
reactant: MODEL1310110026#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
fast: false
reversible: true
product: MODEL1310110026#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110026#

metaM ksi pre9 g
constant: false
is: C00130
is: HMDB00175
is: CHEBI:58053
initial concentration: 1.0
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 9
is: SBO:0000247
notes: FORMULA: C121H196N8O93S2X CHARGE: -3
has only substance units: false
initial amount: NaN
type: Species

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

metaR FACOAL180i
fast: false
reactant: MODEL1310110026#
is described by: ECO:0000269
type: Reaction
name: C180 fatty acid activation
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (22305.2) or (2181.2) or (51703.1) or (2181.1) or (2180.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
modifier: MODEL1310110026#
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110026#_0cdd3649_14ff_4520_8394_a824c40b920b
initial amount: NaN
constant: false
type: Species
is: E2QRH8
name: PLCB4
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5332
boundary condition: true
initial concentration: NaN

metaR PROSTGE2t
reversible: true
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
modifier: MODEL1310110026#
fast: false
kinetic law: MODEL1310110026#
is described by: ECO:0000269
name: prostaglandin transport via bicarbonate countertransport
type: Reaction
product: MODEL1310110026#
is: SBO:0000185

metaR r0472
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reactant: MODEL1310110026#
type: Reaction
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
product: MODEL1310110026#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110026#

metaR r1623
modifier: MODEL1310110026#
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110026#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110026#
reversible: true

metaR CYTK6
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
is described by: ECO:0000269
name: cytidylate kinase (CMP,CTP)
fast: false
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
modifier: MODEL1310110026#
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110026#_83aeb41f_2b80_4204_9191_03be00a22a38
is encoded by: hsa:H53099
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: _H53099_1_m
constant: false
type: Species
boundary condition: true
has only substance units: false

metaM dtdp n
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
constant: false
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
is: CHEBI:58369
is: SBO:0000247
is: HMDB01274
initial concentration: 1.0

metaR CYTK8
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
reactant: MODEL1310110026#
modifier: MODEL1310110026#
type: Reaction
reversible: true
product: MODEL1310110026#
name: cytidylate kinase (CMP,dATP)
kinetic law: MODEL1310110026#
is: SBO:0000176

metaM tdchola x
constant: false
initial concentration: 1.0
name: taurochenodeoxycholate
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
is: SBO:0000247
is: HMDB00951
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:9407

metaM chsterol r
initial concentration: 1.0
is: HMDB00067
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: cholesterol
boundary condition: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
type: Species
constant: false
is: CHEBI:16113

metaR r1992
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
kinetic law: MODEL1310110026#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110026#
reactant: MODEL1310110026#
product: MODEL1310110026#
reversible: false

metaM nac e
boundary condition: false
constant: false
is: HMDB01488
is: C00253
notes: FORMULA: C6H4NO2 CHARGE: -1
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
name: Nicotinate
is: CHEBI:0

metaR ARGt4
fast: false
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is: SBO:0000185
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
reversible: false
is described by: ECO:0000304
name: L-arginine transport in via sodium symport
type: Reaction
product: MODEL1310110026#

metaM ksi pre31 g
is: CHEBI:58053
has only substance units: false
is: C00130
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 31
constant: false
is: HMDB00175
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C227H363N16O189S9X CHARGE: -10
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_74f83e74_b030_4558_9e83_facb6846b454
initial concentration: NaN
constant: false
is encoded by: hsa:BF195998
is: SBO:0000252
initial amount: NaN
name: _BF195998_1_x
has only substance units: false
boundary condition: true
type: Species

metaR r1629
product: MODEL1310110026#
is: SBO:0000185
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR RE3000M
kinetic law: MODEL1310110026#
name: RE3000
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110026#
modifier: MODEL1310110026#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_746ac954_9999_4571_91e4_6299ff4594d1
constant: false
name: SLC6A10P
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:386757

http://identifiers.org/biomodels.db/MODEL1310110026#_180ffaf7_c9c5_4173_ae58_710664e4002a
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:10587
type: Species
has only substance units: false
name: TXNRD2

metaR CYTK9
name: cytidylate kinase (CMP,dCTP)
product: MODEL1310110026#
kinetic law: MODEL1310110026#
is described by: ECO:0000269
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
fast: false
reversible: true
is: SBO:0000176
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_12df1012_089d_481b_9f19_7b0d181114f3
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
name: _AL050025_1_c
has only substance units: false
is encoded by: hsa:AL050025
constant: false

metaR C102CPT1
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decadienoylcarnitine
type: Reaction

metaR r1993
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110026#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110026#
is: SBO:0000185
reactant: MODEL1310110026#
product: MODEL1310110026#
type: Reaction

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

metaR MTHFCm
name: methenyltetrahydrifikate cyclohydrolase, mitochondrial
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110026#
kinetic law: MODEL1310110026#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.5.4.9
is version of: http://identifiers.org/ec-code/6.3.4.3
modifier: MODEL1310110026#

metaM pail hs c
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
is: CHEBI:57880
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol(1-)
has only substance units: false
boundary condition: false
initial amount: NaN

metaM ksii core2 pre4 g
is: HMDB00175
type: Species
initial concentration: 1.0
constant: false
name: keratan sulfate II biosynthesis, precursor 4
is: C00130
boundary condition: false
is: SBO:0000247
notes: FORMULA: C53H86N4O38X CHARGE: -1
is: CHEBI:58053
has only substance units: false
initial amount: NaN

metaR r0033
reversible: false
type: Reaction
fast: false
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.6.1.5
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
reactant: MODEL1310110026#
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24

metaM ksii core2 pre1 g
type: Species
initial concentration: 1.0
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 1
notes: FORMULA: C33H53N3O23X CHARGE: -1
is: CHEBI:28067
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110026#_8c959d7b_76a9_443d_ba7a_35b5c2bb58cb
is: SBO:0000252
is encoded by: hsa:55089
initial amount: NaN
constant: false
type: Species
boundary condition: true
is: Q969I6
initial concentration: NaN
has only substance units: false
name: SLC38A4

http://identifiers.org/biomodels.db/MODEL1310110026#_20256869_910a_4044_81e5_59c2c0929f07
is encoded by: hsa:34
boundary condition: true
has only substance units: false
is: SBO:0000252
name: ACADM
initial concentration: NaN
is: P11310
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_205569ca_e19f_4a4f_8eab_6044adb65517
is: SBO:0000252
name: GUCY2F
has only substance units: false
is encoded by: hsa:2986
constant: false
initial amount: NaN
type: Species
is: P51841
initial concentration: NaN
boundary condition: true

metaR r0464
reversible: true
is described by: ECO:0000000
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
reactant: MODEL1310110026#
product: MODEL1310110026#
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
is: SBO:0000176
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_e88617cb_ba0f_4c2a_ba97_65f06a7395a5
name: TAZ
is: Q16635
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:6901
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_b234308b_2fcb_4f12_b105_6994c6570a48
initial amount: NaN
is: Q9NS18
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
constant: false
boundary condition: true
name: GLRX2
is encoded by: hsa:51022

metaM ctp e
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: HMDB00082
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:37563
name: CTP(4-)

metaR ACGAMPM
name: phosphoacetylglucosamine mutase
fast: false
modifier: MODEL1310110026#
reversible: true
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD
product: MODEL1310110026#
type: Reaction
is version of: http://identifiers.org/ec-code/5.4.2.3
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is: SBO:0000176
is described by: ECO:0000269

metaM CE5132 n
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:57923

metaR r1627
kinetic law: MODEL1310110026#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110026#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
product: MODEL1310110026#

metaR r2193
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
type: Reaction
fast: false
modifier: MODEL1310110026#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_09b47b39_2cac_4dbd_b554_731220685af0
initial amount: NaN
is encoded by: hsa:5315
is: SBO:0000252
type: Species
is: B4DNK4
name: PKM2
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false

metaR CRNt
kinetic law: MODEL1310110026#
is described by: ECO:0000269
fast: false
is: SBO:0000185
modifier: MODEL1310110026#
type: Reaction
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
reactant: MODEL1310110026#
name: L-carnitine reversible transport
reversible: true

metaR FAOXC2051843m
name: Beta oxidation of fatty acid
is: SBO:0000176
product: MODEL1310110026#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.3.8.1

metaM ksi deg6 l
name: keratan sulfate I, degradation product 6
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:12936
initial amount: NaN
is: SBO:0000247
is: HMDB00143
initial concentration: 1.0
notes: FORMULA: C210H336N15O184S11 CHARGE: -11
constant: false

metaR C8DCc
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberylcarnitine
type: Reaction

metaR r0463
reactant: MODEL1310110026#
product: MODEL1310110026#
kinetic law: MODEL1310110026#
type: Reaction
fast: false
name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:
is: SBO:0000176

metaR r1628
reversible: true
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110026#
fast: false
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_dd2dcf9c_54c7_48e8_99fd_701192f7e280
boundary condition: true
name: _D87002_1_m
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:D87002
has only substance units: false
type: Species
constant: false

metaM arachcrn m
is: HMDB06460
name: arachidyl carnitine
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3

metaM inost c
type: Species
is: CHEBI:17268
constant: false
name: myo-inositol
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB00211
boundary condition: false

metaR ILEt5m
is described by: ECO:0000000
reactant: MODEL1310110026#
name: Isoleucine mitochondrial transport
product: MODEL1310110026#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
kinetic law: MODEL1310110026#
fast: false
reversible: true
is: SBO:0000185

metaR FUCtly
fast: false
product: MODEL1310110026#
type: Reaction
name: L-fucose efflux from lysosome
reactant: MODEL1310110026#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:
reversible: false
kinetic law: MODEL1310110026#

metaM glac c
has only substance units: false
type: Species
is: HMDB06355
initial amount: NaN
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:18268
name: D-glucurono-6,3-lactone

metaR ALADGLYexR
is: SBO:0000185
is described by: ECO:0000304
name: D-alanine/glycine reversible exchange
type: Reaction
modifier: MODEL1310110026#
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: true

metaR CBPS
type: Reaction
is: SBO:0000176
modifier: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Pyrimidine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.1.3.2
reversible: false
fast: false
name: carbamoyl-phosphate synthase (glutamine-hydrolysing)

metaR EX dmhptcrn LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2,6 dimethylheptanoyl carnitine exchange
type: Reaction

metaR r2195
product: MODEL1310110026#
modifier: MODEL1310110026#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
reactant: MODEL1310110026#
fast: false
kinetic law: MODEL1310110026#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110026#_2b9fca13_70db_4104_b3b7_9a6cbd91e4f9
is encoded by: hsa:23563
name: CHST5
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is: Q9GZS9
initial amount: NaN
is: SBO:0000252
constant: false

metaM chsterol m
is: SBO:0000247
name: cholesterol
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:16113
is: HMDB00067
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187

metaR MAN1PT2
is described by: ECO:0000000
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.13
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (29926.2) or (29926.1) or (29925.2) or (29925.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.22 Confidence Level: 0 AUTHORS: NOTES:JLR
kinetic law: MODEL1310110026#
name: mannose-1-phosphate guanylyltransferase (GDP)
reversible: false
is: SBO:0000176
modifier: MODEL1310110026#
product: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_e90ad866_40ce_4a04_b607_5a22f7a52b29
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:U37519
is: SBO:0000252
constant: false
name: _U37519_1_e
initial concentration: NaN
initial amount: NaN

metaR FACOAL1813
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
type: Reaction
fast: false
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000269

metaR EX retfa LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid retinol exchange
type: Reaction

metaM cs e deg5 l
type: Species
notes: FORMULA: C31H47NO35S3 CHARGE: -4
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 5
boundary condition: false
initial concentration: 1.0
is: CHEBI:57737
is: SBO:0000247
is: HMDB00868
initial amount: NaN
constant: false
has only substance units: false

metaR NAHCO3 HCLt
is described by: ECO:0000269
fast: false
reactant: MODEL1310110026#
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
product: MODEL1310110026#
reversible: true
name: bicarbonate transport (HCl/NaHCO3 exchange)
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110026#

metaR r2194
type: Reaction
kinetic law: MODEL1310110026#
product: MODEL1310110026#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110026#

metaM inost e
constant: false
is: CHEBI:17268
name: myo-inositol
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB00211
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
has only substance units: false
type: Species
initial concentration: 1.0

metaR FACOAL260
reversible: true
is: SBO:0000176
modifier: MODEL1310110026#
product: MODEL1310110026#
is described by: ECO:0000000
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
name: fatty-acid--CoA ligase (n-C26:0)
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:cytoplasmic version -NJ

metaM cholcoa x
name: choloyl-CoA(4-)
constant: false
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
initial amount: NaN
is: HMDB01374
initial concentration: 1.0
is: CHEBI:57373

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_a8c5d6be_b23e_4e6e_86da_06d0954706c2
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:89869
type: Species
is: SBO:0000252
is: Q86YW0
initial amount: NaN
name: PLCZ1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110026#_2cc524fe_64bc_4a80_b06c_49d83ef991e6
constant: false
is: P53794
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6526
name: SLC5A3
initial amount: NaN
type: Species
boundary condition: true

metaR FACOAL1812
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
reversible: true
reactant: MODEL1310110026#
product: MODEL1310110026#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
fast: false
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#

metaM man c
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
name: D-Mannose
constant: false
is: CHEBI:16024
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
is: C00159
is: HMDB00169
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_eb93efa6_3ecb_4b37_bbe9_7a7ff93ed1c2
name: ALDH5A1
constant: false
is: Q546H9
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:7915
is: SBO:0000252
boundary condition: true

metaM chsterol l
is: CHEBI:16113
has only substance units: false
is: HMDB00067
name: cholesterol
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
initial amount: NaN
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110026#_f73e4aba_ae76_4327_8d73_f20e8a9ee030
type: Species
constant: false
boundary condition: true
has only substance units: false
name: PDE9A
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5152

metaM nac c
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H4NO2 CHARGE: -1
boundary condition: false
initial concentration: 1.0
is: CHEBI:0
is: C00253
type: Species
is: HMDB01488
constant: false
initial amount: NaN
name: Nicotinate

metaR r2197
type: Reaction
product: MODEL1310110026#
is: SBO:0000185
reversible: true
modifier: MODEL1310110026#
reactant: MODEL1310110026#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_bc2ae3d2_7346_4ced_a68b_fe51524a04bc
initial concentration: NaN
has only substance units: false
is: Q96C36
is encoded by: hsa:29920
type: Species
name: PYCR2
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR FERO
reversible: false
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (9843.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110026#
is described by: ECO:0000134
reactant: MODEL1310110026#
name: ferroxidase
kinetic law: MODEL1310110026#

metaR PROt2r
reversible: true
name: L-proline reversible transport via proton symport
product: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
is: SBO:0000185
type: Reaction
is described by: ECO:0000304
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_70e921ab_6b23_472e_aea3_3e08f8ce32a6
is: P20674
boundary condition: true
constant: false
type: Species
name: COX5A
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:9377

metaM core7 g
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C16H27N2O10X CHARGE: 0
is: CHEBI:16478
initial amount: NaN
is: SBO:0000247
name: Core 7

http://identifiers.org/biomodels.db/MODEL1310110026#_2edecd6f_e19e_49a1_bbcc_612b9b738586
name: APRT
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:353
boundary condition: true
constant: false
is: P07741

metaR TDCRNe
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of myristoyl carnitine into extra cellular space
type: Reaction

metaR FATP2t
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110026#
fast: false
name: fatty acid electroneutral transport
modifier: MODEL1310110026#
reactant: MODEL1310110026#
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
reversible: true

metaR r2196
modifier: MODEL1310110026#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110026#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110026#
fast: false
kinetic law: MODEL1310110026#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_5b78910f_f69f_4585_af4a_80fb5f6ff020
is encoded by: hsa:5211
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
name: PFKL
has only substance units: false
is: P17858

metaM omhpal c
constant: false
notes: FORMULA: C16H30O3 CHARGE: -1
boundary condition: false
name: w-hydroxypalmiticacid
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB06294

metaM m4masn g
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C46H77N2O35X CHARGE: 0
constant: false
is: SBO:0000247
is: C05881
boundary condition: false
name: (alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_78785cf1_ef7c_45a0_9787_e4ddf3b353b9
boundary condition: true
name: SI
initial amount: NaN
has only substance units: false
type: Species
is: P14410
is: SBO:0000252
is encoded by: hsa:6476
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_3ceed88f_1405_4434_97dd_ceb02516ff8b
name: B3GNT5
initial amount: NaN
is: Q9BYG0
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:84002

http://identifiers.org/biomodels.db/MODEL1310110026#_c9cfeb5e_5261_477c_89cd_58a7188804f9
has only substance units: false
is encoded by: hsa:5498
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
name: PPOX
is: P50336
initial amount: NaN
constant: false

metaM fuc L c
initial amount: NaN
type: Species
has only substance units: false
name: L-fucose
is: HMDB00174
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:18287

metaM 2mb2coa c
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1
constant: false
name: 2-methylcrotonoyl-CoA(4-)
is: HMDB02054
initial concentration: 1.0
boundary condition: false

metaR GALtly
is: SBO:0000185
type: Reaction
fast: false
name: galactose efflux from lysosome
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD

metaR AICARte
kinetic law: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
product: MODEL1310110026#
type: Reaction
name: Transport of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
reactant: MODEL1310110026#
reversible: true

metaM tchola c
name: taurocholic acid
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
constant: false
is: CHEBI:36257
is: HMDB00036
type: Species
initial amount: NaN
has only substance units: false

metaR S4TASE3ly
modifier: MODEL1310110026#
reactant: MODEL1310110026#
name: N-acetylgalactosamine-4-sulfatase, lysosomal
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.12
product: MODEL1310110026#
kinetic law: MODEL1310110026#
type: Reaction
reversible: true
is: SBO:0000176

metaR SGPL12r
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ
is: SBO:0000176
kinetic law: MODEL1310110026#
name: Sphingosine-1-phosphate lyase
fast: false
product: MODEL1310110026#
reactant: MODEL1310110026#
type: Reaction
reversible: false
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/4.1.2.27

metaM ribflv c
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:3554
name: Riboflavin
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB00244
has only substance units: false
notes: FORMULA: C17H20N4O6 CHARGE: 0
is: C00255

http://identifiers.org/biomodels.db/MODEL1310110026#_220cac54_5f56_4604_ad05_8a9c10b68c1e
is: P16930
is: SBO:0000252
is encoded by: hsa:2184
name: FAH
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN

metaR PHEMEt
modifier: MODEL1310110026#
is described by: ECO:0000269
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (113235.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:16143108 NOTES:NCD
is: SBO:0000185
reversible: false
product: MODEL1310110026#
kinetic law: MODEL1310110026#
type: Reaction
fast: false
name: heme transport

metaM arachcrn c
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
constant: false
is: SBO:0000247
has only substance units: false
name: arachidyl carnitine
boundary condition: false
is: HMDB06460
type: Species

metaR DHCHOLESTANATEtm
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reversible: true
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
is: SBO:0000185
type: Reaction
fast: false
name: lipid, flip-flop intracellular transport
is described by: ECO:0000000

metaR HPYRR2x
is version of: http://identifiers.org/ec-code/1.1.1.27
product: MODEL1310110026#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (3948.1) or (197257.1) or (3945.1) or (160287.1) or (3945.1 and 3939.1) or (92483.1) or (3939.1) or (197257.2) or (3948.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:14635115,PMID:5635456 NOTES:NCD
reversible: false
kinetic law: MODEL1310110026#
name: hydroxypyruvate reductase (NADH)
is version of: http://identifiers.org/ec-code/1.1.2.4
reactant: MODEL1310110026#
modifier: MODEL1310110026#
is: SBO:0000176
fast: false
type: Reaction

metaM m5masnB2 g
boundary condition: false
notes: FORMULA: C52H87N2O40X CHARGE: 0
type: Species
is: SBO:0000247
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
constant: false
initial concentration: 1.0
is: CHEBI:58401
has only substance units: false
is: HMDB06814
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_f1eb7b83_b9e9_4cf7_b2df_c4c5c8a4e3b9
is encoded by: hsa:AA203143
constant: false
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: _AA203143_1_c

metaR RE1448N
fast: false
type: Reaction
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
reversible: true
kinetic law: MODEL1310110026#
is: SBO:0000176
name: RE1448
is described by: ECO:0000000
product: MODEL1310110026#

metaR NACHEXA18ly
is: SBO:0000176
name: beta-N-acetylhexosaminidase A, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110026#
fast: false

metaM 3oddcoa m
has only substance units: false
is: HMDB03937
type: Species
name: 3-Oxododecanoyl-CoA
constant: false
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
is: SBO:0000247
is: CHEBI:27868
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaM na1 c
notes: FORMULA: Na CHARGE: 1
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: C01330
has only substance units: false
type: Species
is: CHEBI:4541
name: Sodium
is: HMDB00588
constant: false
initial concentration: 1.0

metaM ivcrn c
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
name: isovaleryl carnitine
initial amount: NaN
constant: false
is: HMDB00688
notes: FORMULA: C12H23NO4 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110026#_746e8d53_3fa2_4dc4_8dbf_3a820df23ec1
initial concentration: NaN
has only substance units: false
name: CYB5D1
is encoded by: hsa:124637
initial amount: NaN
constant: false
is: SBO:0000252
is: Q6P9G0
type: Species
boundary condition: true

metaR ARACHCPT2
reactant: MODEL1310110026#
reversible: false
fast: false
product: MODEL1310110026#
is described by: ECO:0000000
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
name: carnitine transferase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110026#_bf7846e3_82b7_405b_bda2_d74567f8a331
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
type: Species
name: COX6A2
is: SBO:0000252
is: Q02221
is encoded by: hsa:1339

metaR r1998
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110026#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110026#
is: SBO:0000185
kinetic law: MODEL1310110026#
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110026#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110026#_5179d48c_098c_41c6_a7d5_025b84a1bfa3
initial amount: NaN
is: SBO:0000297
has only substance units: false
has part: P57054
has part: B2RAU6
is encoded by: hsa:5277
is encoded by: hsa:51227
is encoded by: hsa:5279
boundary condition: true
constant: false
is encoded by: hsa:9091
type: Species
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
initial concentration: NaN

metaR EX acnacngalgbside hs LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: disialyl galactosylgloboside (homo sapiens) exchange
type: Reaction

metaM tchola e
notes: FORMULA: C26H45NO7S CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB00036
name: taurocholic acid
has only substance units: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_d5331cc5_0084_4498_aa1d_72d806f9a91b
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is encoded by: hsa:5152
boundary condition: true
initial amount: NaN
name: PDE9A
is: SBO:0000252

metaM ribflv e
notes: FORMULA: C17H20N4O6 CHARGE: 0
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:3554
constant: false
name: Riboflavin
initial concentration: 1.0
is: HMDB00244
is: SBO:0000247
is: C00255
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_67de4495_daea_4935_b63a_a0db6d3bb1af
type: Species
initial amount: NaN
is encoded by: hsa:4668
boundary condition: true
name: NAGA
is: SBO:0000252
initial concentration: NaN
is: P17050
constant: false
has only substance units: false

metaM ptdcacoa m
notes: FORMULA: C36H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C36H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-27(45)64-20-19-38-26(44)17-18-39-34(48)31(47)36(2,3)22-57-63(54,55)60-62(52,53)56-21-25-30(59-61(49,50)51)29(46)35(58-25)43-24-42-28-32(37)40-23-41-33(28)43/h23-25,29-31,35,46-47H,4-22H2,1-3H3,(H,38,44)(H,39,48)(H,52,53)(H,54,55)(H2,37,40,41)(H2,49,50,51)/p-4/t25-,29-,30-,31+,35-/m0/s1
name: pentadecanoyl Coenzyme A
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB06499
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_69aeb53f_f886_4bb4_9890_e9681dadecf4
is encoded by: hsa:498
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
is: B4DY56
boundary condition: true
name: ATP5A1
type: Species

metaR TALA
is version of: http://identifiers.org/ec-code/2.2.1.2
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
reversible: true
fast: false
kinetic law: MODEL1310110026#
product: MODEL1310110026#
is: SBO:0000176
modifier: MODEL1310110026#
type: Reaction
name: transaldolase
is described by: ECO:0000000

metaR 34HPPte
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
is described by: ECO:0000134
kinetic law: MODEL1310110026#
reversible: true
reactant: MODEL1310110026#
fast: false
name: Transport of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_83db2ef8_409c_452c_9dd5_04cacd1cf21b
is: SBO:0000252
is: B4DX62
initial concentration: NaN
type: Species
constant: false
boundary condition: true
is encoded by: hsa:6487
initial amount: NaN
has only substance units: false
name: ST3GAL3

metaR ASNtN1
reactant: MODEL1310110026#
reversible: true
is described by: ECO:0000269
name: Asparagine transport (Na, H coupled)
modifier: MODEL1310110026#
fast: false
product: MODEL1310110026#
is: SBO:0000185
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
kinetic law: MODEL1310110026#
type: Reaction

metaM HC02210 e
is: CHEBI:34939
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: prostaglandin-d3
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
is: SBO:0000247
constant: false

metaM cholcoa r
boundary condition: false
is: CHEBI:57373
name: choloyl-CoA(4-)
is: HMDB01374
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
is: SBO:0000247
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_1a17044b_c9a7_46ea_bdbd_d8ff96968d29
is: O95139
has only substance units: false
boundary condition: true
is encoded by: hsa:4712
name: NDUFB6
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_ae743801_3e65_4678_82c6_7232100e3770
type: Species
has only substance units: false
is: SBO:0000252
name: _AI620219_1_m
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:AI620219

http://identifiers.org/biomodels.db/MODEL1310110026#_0fd07f63_e4be_4c60_9f55_f9058be1616c
name: GBA
type: Species
initial amount: NaN
is encoded by: hsa:2629
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: B7Z5G2
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110026#_6bed456e_947b_4fa1_8cfd_69b3c42c6243
initial amount: NaN
boundary condition: true
name: DHFR
type: Species
is: SBO:0000252
is encoded by: hsa:1719
initial concentration: NaN
has only substance units: false
constant: false
is: P00374

http://identifiers.org/biomodels.db/MODEL1310110026#_20799d6a_5f7e_45d9_ad85_31328af21ab3
name: SLC6A14
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:11254
has only substance units: false
boundary condition: true
type: Species
is: Q9UN76

http://identifiers.org/biomodels.db/MODEL1310110026#_8af3ef13_5ef6_4809_8856_7eeb73fa9853
name: CA2
initial amount: NaN
type: Species
is encoded by: hsa:760
is: SBO:0000252
is: P00918
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_5932fefc_71b8_40ed_9f51_af79c3ec13f3
is: Q9Y3Y1
type: Species
is: SBO:0000252
name: SLC26A6
initial amount: NaN
is encoded by: hsa:65010
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110026#_9b17a54b_7cce_43d4_8675_6a6a436ba852
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:51292
boundary condition: true
name: GMPR2
is: Q86T14
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR G14T4g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
product: MODEL1310110026#
is: SBO:0000176
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90
reactant: MODEL1310110026#
fast: false
kinetic law: MODEL1310110026#
type: Reaction
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is described by: ECO:0000000

metaR S23T2g
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.4.99.4
type: Reaction
product: MODEL1310110026#
name: beta-galactoside alpha-2,3-sialyltransferase (core 2)
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000000
modifier: MODEL1310110026#
reversible: false
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110026#_ced96875_b168_4ba7_a022_838741505aba
has only substance units: false
constant: false
initial amount: NaN
name: _AI935189_1_m
initial concentration: NaN
is encoded by: hsa:AI935189
is: SBO:0000252
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110026#_53b697e1_1276_4c02_9b85_521c023d2aa9
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: Q5SYN6
name: SLC22A3
constant: false
is encoded by: hsa:6581
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_dec8a962_271f_4d1b_8894_f296e917e9d5
is: SBO:0000252
type: Species
name: CA6
has only substance units: false
is: Q5FC00
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:765
initial amount: NaN

metaM ctp c
is: HMDB00082
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
name: CTP
has only substance units: false
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
boundary condition: false
is: CHEBI:37563
is: C00063
is: SBO:0000247

metaM spc hs c
has only substance units: false
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
type: Species
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/5311445
name: sphingosylphosphorylcholine
constant: false
initial amount: NaN
initial concentration: 1.0

metaM xol7ah2 m
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: 5beta-cholestane-3alpha,7alpha-diol
is: HMDB06893
constant: false
initial concentration: 1.0
is: CHEBI:28047
type: Species
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452

metaR DM mem2emgacpail prot hs r
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM mem2emgacpail prot hs(r)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_6e84c237_b7cc_4e35_ac34_56f2e63b2ffe
initial concentration: NaN
name: _100287639_1_c
is: SBO:0000252
has only substance units: false
is encoded by: hsa:100287639
boundary condition: true
constant: false
type: Species
initial amount: NaN

metaM ksi deg3 l
has only substance units: false
is: CHEBI:30825
name: keratan sulfate I, degradation product 3
type: Species
notes: FORMULA: C233H371N16O205S12 CHARGE: -13
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB00573
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_55b52ec7_f67e_4d7d_9c30_cadf3f229120
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:4701
is: Q6FG42
name: NDUFA7

metaM Rtotalcoa c
type: Species
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
is: HMDB01448
is: CHEBI:16189
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
name: R total Coenzyme A
is: SBO:0000247

metaR LNLNCAt
is described by: ECO:0000000
name: fatty acid transport via diffusion
product: MODEL1310110026#
fast: false
is: SBO:0000185
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
reversible: true
kinetic law: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_7e4cc17a_51d3_4917_9769_c4f8077b1eff
boundary condition: true
has only substance units: false
name: PRPS1
initial concentration: NaN
is: P60891
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:5631
type: Species

metaR GLCNACT U
product: MODEL1310110026#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.141 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
name: UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase (uterus)
type: Reaction
fast: false

metaR r1997
is described by: ECO:0000000
product: MODEL1310110026#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110026#
reversible: false
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110026#
is: SBO:0000185
type: Reaction

metaR CERT2rt
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.7.11.1
reversible: true
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
is described by: ECO:0000000
reactant: MODEL1310110026#
fast: false
type: Reaction
is: SBO:0000185
modifier: MODEL1310110026#
product: MODEL1310110026#
name: ceramide transport protein

metaM chsterol e
is: HMDB00067
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
initial concentration: 1.0
name: cholesterol
boundary condition: false
is: SBO:0000247
is: CHEBI:16113
has only substance units: false

metaM adp c
name: ADP
type: Species
is: CHEBI:16761
is: HMDB01341
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: C00008
constant: false
is: http://identifiers.org/pubchem.compound/3310
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_fd403272_1561_4942_910c_25d2ccaacb4e
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:3162
is: Q6FH11
name: HMOX1
boundary condition: true
type: Species
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_21085334_6faa_4887_adaf_35260eb2a10d
is: P34059
initial concentration: NaN
initial amount: NaN
type: Species
name: GALNS
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2588
constant: false

metaR UDPGLCter
product: MODEL1310110026#
fast: false
reactant: MODEL1310110026#
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
reversible: true
kinetic law: MODEL1310110026#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
is described by: ECO:0000000

metaM ksi pre14 g
is: CHEBI:28067
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C143H230N10O114S4X CHARGE: -5
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 14
has only substance units: false
initial concentration: 1.0
constant: false

MODEL1310110026
reaction: metaR r1730
species: metaM udpacgal g
species: metaM 3hibutcoa m
area units: area
reaction: metaR q10h2tc
reaction: metaR DM ethamp r
species: metaM amp r
reaction: metaR EX oagd3 hs LPAREN e RPAREN
species: metaM dcyt n
species: metaM fe2 m
reaction: metaR CO2t
species: metaM dtdp c
reaction: metaR RBTt
reaction: metaR EX arach LPAREN e RPAREN
species: metaM dctp c
reaction: metaR CPPPGO
species: metaM retinol e
reaction: metaR GALASE19ly
reaction: metaR MANt1r
species: metaM fad m
reaction: metaR r0754
reaction: metaR r1566
reaction: metaR AHEXASE2ly
species: metaM lys L c
reaction: metaR GLUPRT
species: metaM 5fthf m
species: metaM c12dccoa c
species: metaM dcyt c
reaction: metaR DCYTt
reaction: metaR r1575
species: metaM ump r
species: metaM nm2masn g
reaction: metaR EX h LPAREN e RPAREN
species: metaM cs e deg4 l
reaction: metaR DAGK hs
species: metaM CE2433 m
reaction: metaR 3HCO3 NAt
species: metaM c101crn e
reaction: metaR r2359
species: metaM idour l
reaction: metaR ASPTAm
reaction: metaR S6TASE8ly
reaction: metaR EX glc LPAREN e RPAREN
reaction: metaR FBA
reaction: metaR r0522
species: metaM fol c
reaction: metaR GAO1g
reaction: metaR EX dhdascb LPAREN e RPAREN
species: metaM ppa c
species: metaM HC02217 e
species: metaM pi g
reaction: metaR RETt
reaction: metaR EX HC02205 LPAREN e RPAREN
reaction: metaR r1615
reaction: metaR r2420
reaction: metaR DAG HSter
species: metaM L2aadp c
reaction: metaR EX inost LPAREN e RPAREN
reaction: metaR EX c5dc
reaction: metaR B3GALTg
reaction: metaR GLCt4
species: metaM udp r
species: metaM ksi pre17 g
reaction: metaR GLNtN1
reaction: metaR NACHEX22ly
reaction: metaR EX amp LPAREN e RPAREN
species: metaM paf hs e
reaction: metaR RE1807M
reaction: metaR r2119
species: metaM Rtotal2coa c
species: metaM gam6p c
species: metaM ksi deg24 l
reaction: metaR HOXG
species: metaM prostgh2 e
reaction: metaR NDPK6m
species: metaM ach e
reaction: metaR GLRASE
reaction: metaR BTNPL
reaction: metaR FACOAL1821
reaction: metaR FRDPtr

metaR r1994
type: Reaction
modifier: MODEL1310110026#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110026#
is: SBO:0000185
product: MODEL1310110026#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110026#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR ARACHCPT1
type: Reaction
notes: GENE_ASSOCIATION: (1375.3) or (1374.1) or (1375.2) or (1375.4) or (1375.1) or (126129.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110026#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110026#
fast: false
is: SBO:0000176
modifier: MODEL1310110026#
product: MODEL1310110026#
name: carnitine transferase
reversible: false

metaM m8mpdol U r
type: Species
constant: false
notes: FORMULA: C1725H2840N20O620P20 CHARGE: -20 INCHI: InChI=1S/C95H162N2O62P2/c1-34(2)13-9-14-35(3)15-10-16-36(4)17-11-18-37(5)19-12-20-38(6)21-22-138-160(132,133)159-161(134,135)158-86-53(97-40(8)108)64(119)77(49(31-106)147-86)150-85-52(96-39(7)107)63(118)78(48(30-105)146-85)151-91-76(131)80(153-94-84(71(126)60(115)46(28-103)144-94)157-95-83(70(125)59(114)47(29-104)145-95)156-90-74(129)67(122)56(111)43(25-100)141-90)62(117)51(149-91)32-136-87-75(130)79(152-93-82(69(124)58(113)45(27-102)143-93)155-89-73(128)66(121)55(110)42(24-99)140-89)61(116)50(148-87)33-137-92-81(68(123)57(112)44(26-101)142-92)154-88-72(127)65(120)54(109)41(23-98)139-88/h13,15,17,19,38,41-95,98-106,109-131H,9-12,14,16,18,20-33H2,1-8H3,(H,96,107)(H,97,108)(H,132,133)(H,134,135)/b35-15+,36-17+,37-19+/t38?,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77-,78-,79+,80+,81+,82+,83+,84+,85+,86-,87+,88-,89-,90-,91+,92+,93-,94-,95-/m1/s1
initial amount: NaN
is: CHEBI:59093
is: SBO:0000247
has only substance units: false
name: (alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial concentration: 1.0
boundary condition: false

metaR r0698
is: SBO:0000176
fast: false
modifier: MODEL1310110026#
reversible: true
reactant: MODEL1310110026#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:12543708,PMID:3746130,PMID:6378901 NOTES:
is version of: http://identifiers.org/ec-code/3.1.2.27
product: MODEL1310110026#
name: Propanoyl-CoA:acetyl-CoA C-acyltransferase Bile acid biosynthesis EC:2.3.1.16
kinetic law: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_4ce4ab04_ebc4_49c3_95c0_403bf8b31324
is encoded by: hsa:292
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: SLC25A5
is: Q6NVC0
initial concentration: NaN
boundary condition: true
constant: false

metaM lnlncg c
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB03073
type: Species
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
name: gamma-linolenate
is: CHEBI:32391

metaR PROSTGD2t
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
fast: false
product: MODEL1310110026#
type: Reaction
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110026#
is: SBO:0000185
name: prostaglandin transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110026#_d971ff35_1257_4a06_97fc_afb718872eca
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:4905
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is: P46459
name: NSF

metaR r1995
type: Reaction
product: MODEL1310110026#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110026#
reversible: false
modifier: MODEL1310110026#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110026#
is: SBO:0000185

metaM ivcrn e
has only substance units: false
notes: FORMULA: C12H23NO4 CHARGE: 0
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
name: isovaleryl carnitine
boundary condition: false
is: HMDB00688

metaM CE5132 c
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:57923
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
type: Species
constant: false

metaM chsterol c
is: SBO:0000247
type: Species
is: HMDB00067
initial amount: NaN
constant: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
name: cholesterol
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:16113

http://identifiers.org/biomodels.db/MODEL1310110026#_c1c476d9_d07e_4804_95c2_625d53b2ae92
has only substance units: false
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: Q6FGQ4
boundary condition: true
is encoded by: hsa:5538
name: PPT1

metaM fuc L l
initial concentration: 1.0
type: Species
is: CHEBI:18287
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
name: L-fucose
is: HMDB00174
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626

http://identifiers.org/biomodels.db/MODEL1310110026#_77544a54_0dd9_4532_bb82_19374ebcf1f6
constant: false
has only substance units: false
is encoded by: hsa:5277
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: PIGA
boundary condition: true
type: Species

metaR GMPtg
reactant: MODEL1310110026#
name: GMP transport (Golgi)
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:
product: MODEL1310110026#
reversible: true
is described by: ECO:0000269
fast: false

metaR NDPK9
name: nucleoside-diphosphate kinase (ATP:IDP)
fast: false
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
type: Reaction
reactant: MODEL1310110026#
is described by: ECO:0000269
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_b89c28d1_4933_49bb_ba61_6daf6a9d0b1d
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:AI924226
name: _AI924226_1_m
initial concentration: NaN
constant: false
initial amount: NaN

metaM msa m
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: 3-oxopropanoate
type: Species
is: HMDB11111
is: CHEBI:33190
has only substance units: false
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222

metaM 3hexdcrn e
name: 3-hydroxyhexadecanoylcarnitine
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C23H45NO5 CHARGE: 0
is: HMDB13336
constant: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110026#_81498af8_f2d9_484e_8c7a_8c32180465e8
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
name: GRHPR
is: Q9UBQ7
initial concentration: NaN
type: Species
is encoded by: hsa:9380

metaR r2063
modifier: MODEL1310110026#
is described by: ECO:0000000
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110026#
product: MODEL1310110026#
fast: false

metaM hpyr c
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01352
constant: false
name: 3-hydroxypyruvate
type: Species
initial amount: NaN
notes: FORMULA: C3H3O4 CHARGE: -1 INCHI: InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00163 EHMN_ABBREVIATION: C00168
is: CHEBI:17180

metaM tag hs c
boundary condition: false
has only substance units: false
is: CHEBI:17855
initial amount: NaN
type: Species
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
name: triglyceride
initial concentration: 1.0
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_63be38c2_a2ba_4915_ae14_f96614116ef2
is encoded by: hsa:3988
boundary condition: true
initial amount: NaN
name: LIPA
is: P38571
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species

metaM galgluside hs g
initial concentration: 1.0
is: CHEBI:58223
is: C00015
constant: false
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB00295
name: galactosyl glucosyl ceramide
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_d6b4931a_2b18_49c8_a320_f1d873b18821
name: GLRX
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2745
constant: false
type: Species
boundary condition: true
is: P35754

metaM HC01162 c
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
is: CHEBI:58376
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_6aeda8d4_8a15_4dc1_8a71_8abfd90e0980
type: Species
constant: false
is encoded by: hsa:9791
is: P48651
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: PTDSS1

metaM CE2417 m
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
type: Species
has only substance units: false
is: HMDB11123
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28387
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417

http://identifiers.org/biomodels.db/MODEL1310110026#_e0c956af_b831_48b6_bcf8_30b2d389600b
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:4830
name: NME1
boundary condition: true
has only substance units: false

metaM l2fn2m2masn g
has only substance units: false
is: CHEBI:28067
name: {[galactosyl-(1,4)-N-Acetyl-glucosaminyl-(1,2)-mannosyl-(1,3)-],[N-acetyl-glucosaminyl-(1,2)-mannosyl-(1,6)-]mannosyl-(1,4)-N-acetyl-glucosaminyl-(1,4)-[fucosyl-(1,6)]-N-acetyl-glucosaminyl}asparagine
initial concentration: 1.0
notes: FORMULA: C68H113N4O49X CHARGE: 0
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
boundary condition: false

metaR SERGLNexR
is: SBO:0000185
fast: false
is described by: ECO:0000304
type: Reaction
name: L-Serine/Glutamine reversible exchange
modifier: MODEL1310110026#
reversible: true
product: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_1ca060b5_565f_4c3f_a1dd_d8222058d88a
has only substance units: false
constant: false
boundary condition: true
is: P30084
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1892
type: Species
name: ECHS1
is: SBO:0000252

metaR PSP L
modifier: MODEL1310110026#
fast: false
is: SBO:0000176
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (8781.1) or (5723.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 3.1.3.3 Confidence Level: 4 AUTHORS: PMID:9188776,PMID:9573387 NOTES:
type: Reaction
kinetic law: MODEL1310110026#
is described by: ECO:0000269
name: phosphoserine phosphatase (L-serine)
reversible: false
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.1.3.3

metaM spc hs e
constant: false
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5311445
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
name: sphingosylphosphorylcholine

http://identifiers.org/biomodels.db/MODEL1310110026#_915d737e_0623_4576_acdd_51506dc30504
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:5471
constant: false
name: PPAT
is: Q06203

metaR OPAHir
reactant: MODEL1310110026#
fast: false
reversible: false
type: Reaction
product: MODEL1310110026#
is: SBO:0000176
kinetic law: MODEL1310110026#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/3.5.2.9
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (26873.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.5.2.9 Confidence Level: 4 AUTHORS: PMID:9751079 NOTES:AF Added from KEGG
name: 5-Oxoproline amidohydrolase (ATP-hydrolysing) (ir)

metaM 3hexdcrn c
notes: FORMULA: C23H45NO5 CHARGE: 0
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB13336
has only substance units: false
name: 3-hydroxyhexadecanoylcarnitine

metaR ST8SIA12
is: SBO:0000176
fast: false
name: Beta-galactoside alpha-2,3-sialyltransferase
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.99.8
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
type: Reaction
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: false
product: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_40842e32_a838_4bf5_bb35_75a29138f925
type: Species
is encoded by: hsa:4729
name: NDUFV2
initial amount: NaN
initial concentration: NaN
constant: false
is: P19404
is: SBO:0000252
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_ad40a0d5_0cfe_4acf_a3d5_5eb9ff923a70
constant: false
is: O43292
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:8733
initial concentration: NaN
name: GPAA1

metaM CE4872 m
is: HMDB00127
type: Species
boundary condition: false
constant: false
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
is: CHEBI:15748
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaR XANDp
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Purine catabolism EC Number: 1.1.1.204 Confidence Level: 4 AUTHORS: PMID:12637268,PMID:8670112 NOTES:Acts on a variety of purines and aldehydes. The animal enzyme can be interconverted to EC 1.1.3.22 xanthine oxidase (the oxidase form). IT
modifier: MODEL1310110026#
reactant: MODEL1310110026#
reversible: false
name: xanthine dehydrogenase, peroxisomal
product: MODEL1310110026#
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.17.1.4
type: Reaction
is: SBO:0000176
fast: false

metaR 34HPPOR
kinetic law: MODEL1310110026#
name: 4-Hydroxyphenylpyruvate:oxygen oxidoreductase
notes: GENE_ASSOCIATION: (3242.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.27 Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110026#
reversible: false
product: MODEL1310110026#
is described by: ECO:0000269
type: Reaction
fast: false
is: SBO:0000176
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.13.11.27

metaM sphs1p c
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: sphingosine 1-phosphate(1-)
is: HMDB00277
boundary condition: false
constant: false
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
is: CHEBI:60119
initial amount: NaN
type: Species

metaR FAOXC2252053m
reactant: MODEL1310110026#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - c22:5,n-3 -> c20:5, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
product: MODEL1310110026#
fast: false
type: Reaction
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
reversible: false
name: Beta oxidation of long chain fatty acid

metaR r1429
is described by: ECO:0000000
product: MODEL1310110026#
reversible: true
is: SBO:0000185
name: Free diffusion
fast: false
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:

metaR 2AMADPTm
modifier: MODEL1310110026#
name: L-2-aminoadipate shuttle (cytosol/mitochondria)
product: MODEL1310110026#
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
type: Reaction
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
is described by: ECO:0000269
fast: false
is: SBO:0000185
reversible: true

metaR BTNDe
product: MODEL1310110026#
name: biotinidase (biotin), extracellular
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7509806,PMID:8001986 NOTES:Also acts on biotin esters IT
fast: false
is: SBO:0000176
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
is described by: ECO:0000269
reversible: false
type: Reaction
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.5.1.12

http://identifiers.org/biomodels.db/MODEL1310110026#_e9ece55a_85f7_4093_8fcb_dd8cf809496b
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: Q8IX04
is encoded by: hsa:55293
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: UEVLD

http://identifiers.org/biomodels.db/MODEL1310110026#_10268454_7bcb_4d77_b005_78a61f866fe4
name: _NOS2A_1_c
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:NOS2A
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaM ptdcacoa c
is: HMDB06499
notes: FORMULA: C36H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C36H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-27(45)64-20-19-38-26(44)17-18-39-34(48)31(47)36(2,3)22-57-63(54,55)60-62(52,53)56-21-25-30(59-61(49,50)51)29(46)35(58-25)43-24-42-28-32(37)40-23-41-33(28)43/h23-25,29-31,35,46-47H,4-22H2,1-3H3,(H,38,44)(H,39,48)(H,52,53)(H,54,55)(H2,37,40,41)(H2,49,50,51)/p-4/t25-,29-,30-,31+,35-/m0/s1
constant: false
has only substance units: false
boundary condition: false
name: pentadecanoyl Coenzyme A
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247

metaM xol7ah2 c
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
is: HMDB06893
has only substance units: false
name: 5beta-cholestane-3alpha,7alpha-diol
is: CHEBI:28047
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_41cdbb3c_d5e4_4612_9640_43ec3556948b
has only substance units: false
initial amount: NaN
is: P24539
type: Species
name: ATP5F1
is encoded by: hsa:515
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

metaR r1428
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110026#
fast: false
name: Free diffusion
reversible: true
product: MODEL1310110026#
kinetic law: MODEL1310110026#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110026#_bebf64f3_b7c8_405e_b37b_37fbbe9fe7ed
initial amount: NaN
has only substance units: false
constant: false
name: ACOT8
is: SBO:0000252
is encoded by: hsa:10005
type: Species
is: O14734
boundary condition: true
initial concentration: NaN

metaM trdrd m
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:15967
name: Reduced thioredoxin
type: Species
boundary condition: false
constant: false
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342

http://identifiers.org/biomodels.db/MODEL1310110026#_427fe3c0_efa6_4b73_84e5_2d62ef264c90
boundary condition: true
is: SBO:0000252
constant: false
is: P48735
name: IDH2
is encoded by: hsa:3418
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false

metaR PPBNGS
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/4.2.1.24
name: porphobilinogen synthase
reactant: MODEL1310110026#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (210.1) or (210.2) SUBSYSTEM: Heme synthesis EC Number: 4.2.1.24 Confidence Level: 4 AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110026#
reversible: false

metaR DNDPt35m
type: Reaction
fast: false
name: dGDP transport via dADP antiport
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110026#
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_b54d25b5_ce8f_41ba_a7b8_456f0c564be2
constant: false
name: CA8
is encoded by: hsa:767
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: P35219
boundary condition: true
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_80381de3_6b8f_40ca_aeeb_873759c487a6
initial amount: NaN
constant: false
is encoded by: hsa:2819
is: F8W1L5
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: GPD1

metaR RE3074X
modifier: MODEL1310110026#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
notes: GENE_ASSOCIATION: (11001.1) or (2182.1) or (2181.1) or (2180.1) or (51703.1) or (23305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:11060359,PMID:11356164 NOTES:IT - fixed proton
reversible: true
name: RE3074
is: SBO:0000176
product: MODEL1310110026#
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000000

metaR RE1845C
reactant: MODEL1310110026#
is described by: ECO:0000000
product: MODEL1310110026#
type: Reaction
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 4 h[c] from compEHMN reaction as they were not necessary
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.65
name: RE1845
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
fast: false
is: SBO:0000176

metaR ADEt
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD
is described by: ECO:0000269
product: MODEL1310110026#
is: SBO:0000185
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110026#
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
name: adenine reversible transport, cytosol

metaR GALASE4ly
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110026#
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
name: beta-galactosidase, lysosomal
is described by: ECO:0000000
type: Reaction
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false

metaR 2DR1PP
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.10 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
reversible: false
reactant: MODEL1310110026#
product: MODEL1310110026#
is: SBO:0000176
name: 2-deoxy-D-ribose 1-phosphate phosphorylase
type: Reaction

metaM xylt c
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
constant: false
is: HMDB02917
is: CHEBI:17151
type: Species
name: xylitol
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR FACOAL150
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR
is: SBO:0000176
reversible: true
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110026#
fast: false

metaM ksi pre29 g
notes: FORMULA: C213H340N15O179S9X CHARGE: -10
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:28067
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 29
constant: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_d3835fd8_7578_4084_b126_457060e3ee9d
boundary condition: true
is encoded by: hsa:51809
is: Q86SF2
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
has only substance units: false
name: GALNT7
is: SBO:0000252

metaR FOLt2le
fast: false
name: folate transport via anion exchange
type: Reaction
reactant: MODEL1310110026#
reversible: true
is described by: ECO:0000134
kinetic law: MODEL1310110026#
is: SBO:0000185
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaM CE2433 m
is: SBO:0000247
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
constant: false
is: CHEBI:57795
initial concentration: 1.0
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species

metaR r1630
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110026#_9d7128c0_96c2_4d0a_aff2_16868aeb6334
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:218
name: ALDH3A1
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: P30838

http://identifiers.org/biomodels.db/MODEL1310110026#_b6603866_aeaa_400c_aa50_7ee735e7612f
initial concentration: NaN
is: O95470
name: SGPL1
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:8879
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_5856c9e9_1575_43e8_8a38_6092f343b258
constant: false
name: ACSS2
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:55902
is: Q5QPH3

metaM udpacgal l
is: SBO:0000247
initial amount: NaN
is: HMDB00304
is: CHEBI:57847
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
name: UDP-N-acetyl-D-galactosamine(2-)

http://identifiers.org/biomodels.db/MODEL1310110026#_bd3e12ef_37d7_47b5_82a0_e88754dc9c7c
boundary condition: true
type: Species
constant: false
initial concentration: NaN
has only substance units: false
is: P16152
name: CBR1
is encoded by: hsa:873
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_c4301d34_f01a_4c31_a7ef_b152b193e05b
is: B3KT84
is encoded by: hsa:195814
boundary condition: true
type: Species
name: SDR16C5
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaM 3hmp m
is: HMDB00023
is: CHEBI:11805
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
initial amount: NaN
name: 3-hydroxy-2-methylpropanoate
type: Species
constant: false
boundary condition: false

metaR DM Lcystin
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for L-cystine
type: Reaction

metaR CYTK8n
modifier: MODEL1310110026#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP,dATP),nuclear
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
product: MODEL1310110026#
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176

metaM xylt e
constant: false
boundary condition: false
is: HMDB02917
initial concentration: 1.0
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
is: CHEBI:17151
type: Species
initial amount: NaN
name: xylitol
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_eb07d663_fc1f_4435_88e3_61d4453b9d67
type: Species
is: SBO:0000252
is encoded by: hsa:4695
name: NDUFA2
boundary condition: true
initial amount: NaN
constant: false
is: O43678
initial concentration: NaN
has only substance units: false

metaR AKGtp
name: AKG transporter, peroxisome
kinetic law: MODEL1310110026#
product: MODEL1310110026#
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110026#

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_e8f50b66_d81e_4537_963d_401869757f44
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is: P08237
name: PFKM
is encoded by: hsa:5213
initial amount: NaN
boundary condition: true

metaR S6T15g
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.8.2.21
reversible: false
is version of: http://identifiers.org/ec-code/2.8.2.17
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110026#
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
modifier: MODEL1310110026#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110026#_7b776b0c_6686_41a9_8bca_3690a5e56275
is: Q6IBA0
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
constant: false
name: NDUFS5
boundary condition: true
is encoded by: hsa:4725
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_9165e82b_f1e6_4287_97a8_a1266b380617
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
is: Q6LEN6
initial concentration: NaN
name: CHAT
constant: false
is encoded by: hsa:1103

metaR HMGCOAtx
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:diffusion NJ
name: Hydroxymethylglutaryl-CoA reversible peroxisomal transport
reactant: MODEL1310110026#
product: MODEL1310110026#
type: Reaction
reversible: true
kinetic law: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_8f0a8ac3_1330_4088_a657_a6c58e0b562f
is: O43280
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:11181
boundary condition: true
type: Species
is: SBO:0000252
name: TREH

metaR NRPPHRtu
fast: false
product: MODEL1310110026#
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
type: Reaction
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
reversible: true
name: Norepinephrine uniport

metaR NACHEXA15ly
product: MODEL1310110026#
type: Reaction
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
kinetic law: MODEL1310110026#
name: beta-N-acetylhexosaminidase A, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110026#
reactant: MODEL1310110026#
reversible: false
fast: false

metaM ksi deg27 l
is: HMDB00143
boundary condition: false
notes: FORMULA: C104H169N7O88S4 CHARGE: -4
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
name: keratan sulfate I, degradation product 27
initial amount: NaN
constant: false
is: CHEBI:12936

metaR TMNDNCt
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
fast: false
type: Reaction
is described by: ECO:0000000
name: fatty acid transport via diffusion

metaM HC00229 e
initial concentration: 1.0
constant: false
initial amount: NaN
name: Isomaltose
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:28189
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_7c811804_470e_47dd_aa8e_90dc4c90db49
is encoded by: hsa:1346
constant: false
initial amount: NaN
has only substance units: false
name: COX7A1
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
is: P24310

metaM lnlccoa m
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
name: linoleic coenzyme A
initial concentration: 1.0
is: HMDB01064
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/5462164
is: SBO:0000247
constant: false
has only substance units: false
type: Species

metaR r1632
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110026#
reactant: MODEL1310110026#
modifier: MODEL1310110026#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
fast: false

metaM c12dc x
type: Species
constant: false
is: HMDB02014
name: dodecanedioyl carnitine
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C19H34NO6 CHARGE: -1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_bea49b34_0781_4b00_bef0_7c49f0b6d284
has only substance units: false
name: _AI640625_1_c
constant: false
is encoded by: hsa:AI640625
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252

metaR ENGASEly
name: endo-beta-N-acetylglucosaminidase, lysosomal
fast: false
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110026#
type: Reaction
reactant: MODEL1310110026#
reversible: false
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

metaR r1423
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110026#
is: SBO:0000185
product: MODEL1310110026#
kinetic law: MODEL1310110026#
name: Facilitated diffusion
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110026#_cee598bc_11bf_4cf9_94d7_ac18081b562b
is: SBO:0000252
type: Species
name: _AI620219_1_e
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:AI620219
initial concentration: NaN

metaM leuktrB4 c
initial amount: NaN
is: HMDB01085
constant: false
is: CHEBI:57461
type: Species
is: SBO:0000247
has only substance units: false
name: leukotriene B4(1-)
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110026#_f7de35ae_ac73_4fc6_b34a_f7a7984fead3
constant: false
name: HK2
is encoded by: hsa:3099
is: SBO:0000252
initial concentration: NaN
is: P52789
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_a23d0eb8_8b0d_45e9_8eea_020dce9b4dc0
type: Species
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: IMPDH2
is encoded by: hsa:3615
is: P12268
initial amount: NaN

metaR r1857
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110026#
reversible: false
kinetic law: MODEL1310110026#
fast: false
product: MODEL1310110026#
reactant: MODEL1310110026#
name: Y+LAT2 Utilized transport

metaR GRTTx
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
reactant: MODEL1310110026#
product: MODEL1310110026#
reversible: false
is: SBO:0000176
name: geranyltranstransferase
fast: false
is described by: ECO:0000134
type: Reaction
is version of: http://identifiers.org/ec-code/2.5.1.1
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ

metaR r1631
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110026#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110026#
is: SBO:0000185

metaM tettet6 e
is: HMDB06246
name: tetracosatetraenoic acid n-6
notes: FORMULA: C24H39O2 CHARGE: -1 INCHI: InChI=1/C24H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h16-23H,2-15H2,1H3,(H,25,26)/b17-16+,19-18+,21-20+,23-22+
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
initial amount: NaN

metaR BILDGLCURt
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
type: Reaction
reversible: true
is: SBO:0000185
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000269
fast: false
product: MODEL1310110026#

metaR r0480
reversible: true
product: MODEL1310110026#
kinetic law: MODEL1310110026#
is: SBO:0000176
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:

metaM ctp n
type: Species
boundary condition: false
is: HMDB00082
constant: false
initial amount: NaN
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
has only substance units: false
name: CTP(4-)
is: SBO:0000247
is: CHEBI:37563
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110026#_003f1054_4208_4e8e_b528_14f2ea879139
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:AI653169
name: _AI653169_1_c
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN

metaR NADS2
modifier: MODEL1310110026#
name: NAD synthase (glutamine-hydrolysing)
reversible: false
kinetic law: MODEL1310110026#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (55191.1) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
fast: false
reactant: MODEL1310110026#
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/6.3.5.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_64e0c7e0_c216_42db_83dd_a49ffdbdd295
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
name: PIGB
initial amount: NaN
is: Q92521
has only substance units: false
is encoded by: hsa:9488

metaM c101coa c
is: C14143
constant: false
type: Species
initial amount: NaN
is: HMDB04047
boundary condition: false
name: decenoylcoa
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_58977427_9d10_47c8_ba8c_8068ff7e30c7
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AI631997
name: _AI631997_1_m
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false

metaM strdnccoa c
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
is: C16163
is: http://identifiers.org/pubchem.compound/47205473
is: HMDB06519
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
name: stearidonyl coenzyme A

metaR NADH2 u10m
is version of: http://identifiers.org/ec-code/1.6.5.3
reversible: false
product: MODEL1310110026#
is: SBO:0000185
type: Reaction
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (4694.1) and (374291.1) and (4728.1) and (4717.1) and (4731.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (4722.1) and (7991.1) and (4541.1) and (4539.1) and (4712.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4706.1) and (4535.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (4712.2) and (4717.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (7991.1) and (4722.1) and (4541.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (126328.1) and (4711.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4729.1) and (4540.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (7991.2) and (4717.1) and (4705.1) and (4725.1) and (4537.1) and (4716.1) and (4722.1) and (4541.1) and (4712.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (374291.1) and (4694.1) and (4728.1) and (4712.2) and (4717.1) and (4731.1) and (…
is version of: http://identifiers.org/ec-code/1.6.99.3
modifier: MODEL1310110026#
reactant: MODEL1310110026#
name: NADH dehydrogenase, mitochondrial

metaM ksi deg14 l
is: HMDB00143
has only substance units: false
type: Species
name: keratan sulfate I, degradation product 14
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C166H267N11O145S8 CHARGE: -8
is: CHEBI:12936
constant: false

metaM n2m2mn l
is: HMDB00243
initial amount: NaN
is: C00022
name: de-Fuc, reducing GlcNAc removed, de-Sia, de-Gal form of PA6 (w/o peptide linkage)
is: http://identifiers.org/pubchem.compound/3324
initial concentration: 1.0
type: Species
is: CHEBI:15361
boundary condition: false
constant: false
notes: FORMULA: C42H71N3O31 CHARGE: 0
is: SBO:0000247
has only substance units: false

metaR r1634
is: SBO:0000185
product: MODEL1310110026#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110026#
fast: false
reversible: true
reactant: MODEL1310110026#

metaM Lpipecol x
initial concentration: 1.0
is: HMDB00716
constant: false
name: L-pipecolic acid
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H11NO2 CHARGE: 0 INCHI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1 EHMN_ABBREVIATION: C00408
boundary condition: false
is: CHEBI:30913
initial amount: NaN

metaR r1421
reactant: MODEL1310110026#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
is described by: ECO:0000000
product: MODEL1310110026#
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110026#
name: Free diffusion

http://identifiers.org/biomodels.db/MODEL1310110026#_3b0070b1_0fae_4dc6_b77b_be71e5263248
constant: false
boundary condition: true
has only substance units: false
is: O14556
initial concentration: NaN
is encoded by: hsa:26330
type: Species
initial amount: NaN
is: SBO:0000252
name: GAPDHS

metaR FACOAL181i
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is: SBO:0000176
modifier: MODEL1310110026#
fast: false
reversible: false
name: C181 fatty acid activation
notes: GENE_ASSOCIATION: (2180.1) or (2181.2) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
product: MODEL1310110026#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269

metaR BTNDm
is described by: ECO:0000269
name: biotinidase (biotin), mitochondrial
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.5.1.12
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:Also acts on biotin esters IT
reversible: false
type: Reaction
product: MODEL1310110026#
modifier: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_f5a938db_4450_407b_b58c_762d80fcdc97
has only substance units: false
is encoded by: hsa:151531
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
name: UPP2
boundary condition: true
is: O95045

metaM chito2pdol U c
has only substance units: false
is: CHEBI:12427
initial amount: NaN
notes: FORMULA: C1185H1940N20O170P20 CHARGE: -20
constant: false
name: N,N'-Diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247

metaM leuktrB4 e
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
name: leukotriene B4(1-)
type: Species
is: CHEBI:57461
is: SBO:0000247
is: HMDB01085
initial amount: NaN

metaM tettet6 c
constant: false
name: tetracosatetraenoic acid n-6
initial amount: NaN
is: HMDB06246
notes: FORMULA: C24H39O2 CHARGE: -1 INCHI: InChI=1/C24H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h16-23H,2-15H2,1H3,(H,25,26)/b17-16+,19-18+,21-20+,23-22+
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247

metaR r1633
reversible: true
kinetic law: MODEL1310110026#
type: Reaction
fast: false
reactant: MODEL1310110026#
is: SBO:0000185
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110026#_2aeffa82_a75b_41bd_91bd_4e3805988a18
boundary condition: true
is: Q6IB80
initial concentration: NaN
has only substance units: false
name: NDUFB3
type: Species
is encoded by: hsa:4709
is: SBO:0000252
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_a21e7aa0_e05b_4d20_ad31_9fd397762a68
is encoded by: hsa:1962
initial concentration: NaN
boundary condition: true
name: EHHADH
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: Q9NY65

http://identifiers.org/biomodels.db/MODEL1310110026#_1b14ad41_0a29_41c8_a9b2_ecb0c7a70b94
has only substance units: false
is: O00750
constant: false
is encoded by: hsa:5287
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
name: PIK3C2B

metaR GALSIDEtl
product: MODEL1310110026#
name: galactocerebroside intracellular transport
reactant: MODEL1310110026#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110026#
type: Reaction

metaR r1636
kinetic law: MODEL1310110026#
type: Reaction
reversible: true
product: MODEL1310110026#
fast: false
modifier: MODEL1310110026#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110026#
is: SBO:0000185

metaM lnlccoa r
is: http://identifiers.org/pubchem.compound/5462164
constant: false
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB01064
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
name: linoleic coenzyme A
has only substance units: false
initial amount: NaN

metaR P450SCC1m
is described by: ECO:0000134
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
fast: false
reversible: true
name: cholesterol monooxygenase
product: MODEL1310110026#
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_fd06b035_54d7_4c38_9c4a_4df23c653268
is encoded by: hsa:55229
initial amount: NaN
is: SBO:0000252
constant: false
is: Q9NVE7
has only substance units: false
boundary condition: true
name: PANK4
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_67e929c7_432a_4ff1_9f44_ad89276be803
is: SBO:0000252
is encoded by: hsa:4695
name: NDUFA2
initial concentration: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true
is: O43678
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_b2cda2cd_0080_42a4_ae78_34b4bb125dea
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:6185
boundary condition: true
name: RPN2
constant: false
initial concentration: NaN
has only substance units: false
is: P04844

metaR r0483
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
reversible: true
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
product: MODEL1310110026#
is: SBO:0000176
kinetic law: MODEL1310110026#
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110026#

metaR r1635
product: MODEL1310110026#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110026#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
is described by: ECO:0000000

metaR ADPCOAPTE
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of adipoyl coA for release into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_72dcb650_5354_40f4_9a32_f82c480935a8
initial amount: NaN
has only substance units: false
boundary condition: true
name: CA12
constant: false
is: O43570
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:771

http://identifiers.org/biomodels.db/MODEL1310110026#_0e919ce2_9ff5_49f3_8e23_3d74df8b7862
is encoded by: hsa:221
boundary condition: true
constant: false
is: SBO:0000252
type: Species
name: ALDH3B1
initial amount: NaN
initial concentration: NaN
is: P43353
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_70877d6e_abf1_43a1_ad18_6d81df92dc53
is encoded by: hsa:641372
has only substance units: false
is: Q3I5F7
type: Species
boundary condition: true
name: ACOT6
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

metaM g1m8mpdol U r
has only substance units: false
notes: FORMULA: C1785H2940N20O670P20 CHARGE: -20
initial amount: NaN
constant: false
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
type: Species
is: SBO:0000247
is: CHEBI:59093
initial concentration: 1.0
boundary condition: false

metaR EX chtn LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chitin exchange
type: Reaction

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

metaR RE1342C
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
name: RE1342
product: MODEL1310110026#
type: Reaction
fast: false
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
reversible: true

metaR S6T4g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
modifier: MODEL1310110026#
reversible: false
is described by: ECO:0000000
product: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is: SBO:0000176
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110026#_45f0d2f9_5d14_4442_81db_7d89fb703f3f
name: SLC3A2
type: Species
constant: false
initial concentration: NaN
is: P08195
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:6520

metaR PHYTt
is described by: ECO:0000000
product: MODEL1310110026#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
name: fatty acid transport via diffusion
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#

metaR APOC LYS BTNPm
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is: SBO:0000176
name: proteolysis of apoC-Lys-btn, mitochondrial
reversible: false
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

metaR FAOXC5OHc
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: (3-hydroxyisovalerylcoa-->3-hydroxyisovalerylcarnitine)c
type: Reaction

metaM sphs1p e
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: sphingosine 1-phosphate(1-)
constant: false
type: Species
is: HMDB00277
has only substance units: false
is: CHEBI:60119
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110026#_bdd78da9_6d10_4937_a34c_0d758026aa76
name: UCK2
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:7371
is: SBO:0000252
type: Species
boundary condition: true
is: Q9BZX2

metaR r1638
kinetic law: MODEL1310110026#
reversible: true
fast: false
product: MODEL1310110026#
is described by: ECO:0000000
reactant: MODEL1310110026#
is: SBO:0000185
modifier: MODEL1310110026#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaR RE3567C
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110026#
reversible: true
name: RE3567
is: SBO:0000176
product: MODEL1310110026#
fast: false
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110026#_1fb1aecc_fd02_4439_8bed_806993a080eb
name: EGFR
type: Species
is encoded by: hsa:1956
is: P00533
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false

metaM tag hs e
initial concentration: 1.0
constant: false
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
name: triglyceride
boundary condition: false
is: CHEBI:17855

metaR Htg
fast: false
kinetic law: MODEL1310110026#
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: proton diffusion (Golgi)
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110026#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110026#_d3268012_cbce_46bb_9af3_9bd7941a9cfa
is: P41222
type: Species
name: PTGDS
constant: false
initial amount: NaN
is encoded by: hsa:5730
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR r1637
fast: false
product: MODEL1310110026#
type: Reaction
reactant: MODEL1310110026#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#

metaR BDMT U
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.4.1.142
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (56052.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110026#
fast: false
product: MODEL1310110026#
is: SBO:0000176
type: Reaction
name: GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (uterus)

metaR MTHFD2
is: SBO:0000176
is described by: ECO:0000134
reversible: true
product: MODEL1310110026#
kinetic law: MODEL1310110026#
name: methylenetetrahydrofolate dehydrogenase (NAD)
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.9
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
type: Reaction
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_4d714783_78a8_4e97_a65a_d0cd4dc0c5e0
is: SBO:0000252
initial concentration: NaN
name: RDH12
is encoded by: hsa:145226
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q96NR8
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_57fdc76e_2316_43bb_8453_ebe6e1acae32
boundary condition: true
name: GALNT10
type: Species
initial concentration: NaN
is encoded by: hsa:55568
initial amount: NaN
is: Q86SR1
constant: false
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110026#_a6f84282_3c90_49aa_a128_89727448a582
name: ATP1B4
is encoded by: hsa:23439
constant: false
is: SBO:0000252
is: Q9UN42
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN

metaR r1538
is version of: http://identifiers.org/ec-code/1.17.4.1
is described by: ECO:0000000
fast: false
is: SBO:0000185
name: Anion Exchanger (AE) TCDB:2.A.31.2.8
reactant: MODEL1310110026#
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
type: Reaction
reversible: false
product: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_fb884673_000b_43ba_9903_a53b5a64efcf
initial concentration: NaN
initial amount: NaN
name: SLC22A2
constant: false
has only substance units: false
is encoded by: hsa:6582
is: SBO:0000252
type: Species
boundary condition: true

metaM hexdicoa c
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
name: hexadecanedioylcoa
initial amount: NaN
constant: false
type: Species
is: HMDB02014

metaR SPHS1Ptr
is: SBO:0000185
fast: false
is described by: ECO:0000000
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
product: MODEL1310110026#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414 or PMID: 15585321). NJ
reversible: true
name: sphingosine-1-phosphate transport

metaR HDECAACBP
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyhexadecanoylcoa from mitochondria into the cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_3c737da2_5106_4d5d_9871_650756db1647
boundary condition: true
initial concentration: NaN
is encoded by: hsa:111
is: SBO:0000252
constant: false
has only substance units: false
is: O95622
type: Species
name: ADCY5
initial amount: NaN

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_ee5db977_a358_40cc_a837_511352d369c8
has only substance units: false
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:788
name: SLC25A20
boundary condition: true
is: O43772
initial concentration: NaN
is: SBO:0000252

metaM h2o m
initial concentration: 1.0
is: SBO:0000247
constant: false
is: C00001
is: HMDB02111
boundary condition: false
has only substance units: false
is: CHEBI:15377
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
name: H2O
type: Species
initial amount: NaN

metaR r1318
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
product: MODEL1310110026#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_06d5e92e_686a_4878_a1cd_beac4c20ffc9
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:1798
initial amount: NaN
name: DPAGT1
initial concentration: NaN
type: Species
is: SBO:0000252

metaM CE0785 m
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
name: cis,cis-myristo-5,8-dienoyl-CoA
is: CHEBI:57795

http://identifiers.org/biomodels.db/MODEL1310110026#_7bc312f1_c4f7_4641_af70_efd959b85378
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6565
name: SLC15A2
boundary condition: true
type: Species
is: Q16348

metaR RE3001M
is version of: http://identifiers.org/ec-code/1.3.1.34
type: Reaction
name: RE3001
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: true
product: MODEL1310110026#
is described by: ECO:0000000
reactant: MODEL1310110026#
is: SBO:0000176
fast: false

metaR G3PD1
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
product: MODEL1310110026#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110026#
name: glycerol-3-phosphate dehydrogenase (NAD)
is: SBO:0000176
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.1.1.8
modifier: MODEL1310110026#
fast: false
reversible: true

metaR S23T3g
is: SBO:0000176
product: MODEL1310110026#
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (6487.4) or (6487.9) or (6487.11) or (6487.6) or (6487.7) or (6487.10) or (6487.5) or (6487.1) or (6487.2) or (6487.8) or (6487.3) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.6 Confidence Level: 4 AUTHORS: PMID:8333853 NOTES:NCD
name: beta-galactoside alpha-2,3-sialyltransferase (complex N-glycan)
is version of: http://identifiers.org/ec-code/2.4.99.6
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110026#
fast: false
modifier: MODEL1310110026#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110026#_71216953_a70f_423c_84cd_63efdf79be17
constant: false
type: Species
name: GGT2
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:728441
is: SBO:0000252

metaR r1639
reversible: true
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110026#
fast: false
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110026#

metaR SUBERICACT
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of suberic acid for formation of suberyl carnitine
type: Reaction

metaR r1850
is described by: ECO:0000000
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Y+LAT2 Utilized transport
modifier: MODEL1310110026#
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
fast: false
is: SBO:0000185
reversible: false

metaR r0475
reactant: MODEL1310110026#
product: MODEL1310110026#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
kinetic law: MODEL1310110026#
type: Reaction
fast: false
reversible: true
is described by: ECO:0000000
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1

http://identifiers.org/biomodels.db/MODEL1310110026#_a07148d9_4332_421f_be48_c1498966723e
type: Species
is encoded by: hsa:5244
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: A4D1D5
is: SBO:0000252
boundary condition: true
name: ABCB4

metaR GALSIDEtg
reactant: MODEL1310110026#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
type: Reaction
product: MODEL1310110026#
name: galactocerebroside intracellular transport
is described by: ECO:0000000
kinetic law: MODEL1310110026#
fast: false

metaR ARACHDCOAtx
type: Reaction
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
name: fatty acid intracellular transport
reversible: true
reactant: MODEL1310110026#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110026#
fast: false

metaM h2o n
name: water
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: HMDB02111
is: CHEBI:15377
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_ea042acf_aacc_4762_9d0c_26ecd696cff5
constant: false
is: SBO:0000252
boundary condition: true
type: Species
name: MDH2
is: P40926
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4191
initial amount: NaN

metaM dpcoa e
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: C00882
is: HMDB01373
boundary condition: false
name: Dephospho-CoA
is: CHEBI:57328
type: Species
constant: false

metaR PYRt2r
modifier: MODEL1310110026#
reactant: MODEL1310110026#
fast: false
is: SBO:0000185
name: pyruvate reversible transport via proton symport
is described by: ECO:0000269
product: MODEL1310110026#
type: Reaction
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
kinetic law: MODEL1310110026#
reversible: true

metaM adp x
has only substance units: false
is: CHEBI:456216
is: SBO:0000247
initial concentration: 1.0
constant: false
name: ADP(3-)
type: Species
is: HMDB01341
initial amount: NaN
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110026#_cba19155_d9d3_47ae_a4b7_8734d5419bfe
boundary condition: true
is: Q9HBH5
type: Species
is encoded by: hsa:57665
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
name: RDH14

metaR A4GALTg
name: Lactosylceramide 4-alpha-galactosyltransferase
reversible: false
fast: false
notes: GENE_ASSOCIATION: (53947.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.228 Confidence Level: 4 AUTHORS: PMID:10747952,PMID:10748143 NOTES:EC: 2.4.1.228 NJ
is version of: http://identifiers.org/ec-code/2.4.1.228
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110026#
is: SBO:0000176
product: MODEL1310110026#
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_aeae45bc_6588_42d6_9e58_b55d8277f1f2
constant: false
initial concentration: NaN
is encoded by: hsa:6487
is: SBO:0000252
type: Species
is: Q11203
has only substance units: false
initial amount: NaN
boundary condition: true
name: ST3GAL3

metaR GGT5r
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
reversible: true
type: Reaction
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.3.2.2
name: Gamma-glutamyltransferase 5
notes: GENE_ASSOCIATION: (2687.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:18357468,PMID:18357469,PMID:6120203 NOTES:Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). NJ
is: SBO:0000176
fast: false
modifier: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_2a63da9d_a5b4_4ea5_9dd1_cf7f3bd1b45b
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
name: HK3
constant: false
is: SBO:0000252
is encoded by: hsa:3101
initial concentration: NaN
is: P52790

metaR RE1845X
type: Reaction
name: RE1845
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.3.1.65
fast: false
is: SBO:0000176
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 1 h[c] from compEHMN reaction as they were not necessary
reversible: true
is described by: ECO:0000000
product: MODEL1310110026#
kinetic law: MODEL1310110026#

metaR r0474
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110026#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
product: MODEL1310110026#
kinetic law: MODEL1310110026#

metaR FACOAL1822
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
reversible: true
is: SBO:0000176
is described by: ECO:0000269
fast: false

metaR ADSL1
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110026#
modifier: MODEL1310110026#
reversible: false
is version of: http://identifiers.org/ec-code/4.3.2.2
fast: false
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
is: SBO:0000176
name: adenylosuccinate lyase

metaR r0688
kinetic law: MODEL1310110026#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110026#
modifier: MODEL1310110026#
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
reactant: MODEL1310110026#
is: SBO:0000176
fast: false
reversible: true
type: Reaction

metaM dpcoa c
initial amount: NaN
has only substance units: false
is: CHEBI:57328
constant: false
is: C00882
is: HMDB01373
is: SBO:0000247
boundary condition: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
name: Dephospho-CoA
initial concentration: 1.0
type: Species

metaR FACOAL1821
name: fatty-acid--CoA ligase
is described by: ECO:0000269
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ, RE1514C
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110026#
reversible: true
product: MODEL1310110026#
reactant: MODEL1310110026#
is: SBO:0000176
modifier: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_72ab0d89_e5a7_4fbf_8720_bae5d3fc2436
initial amount: NaN
is: B1AM93
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4702
name: NDUFA8
type: Species
constant: false
boundary condition: true
has only substance units: false

metaR FAOXC183806m
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation of fatty acid
product: MODEL1310110026#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 3 degrees loss of saturation -> only 2 fad oxidized to fadh2 - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c18:3,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ

metaR PYRt2p
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: D-alanine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12705896,PMID:12739169,PMID:9786900 NOTES:NCD
fast: false
reactant: MODEL1310110026#
product: MODEL1310110026#
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110026#
type: Reaction
name: pyruvate peroxisomal transport via proton symport
reversible: true
modifier: MODEL1310110026#

metaM lnlccoa c
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
name: linoleic coenzyme A
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5462164
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
is: HMDB01064
type: Species
initial amount: NaN

metaR ADSL2
type: Reaction
fast: false
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Purine synthesis EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
is version of: http://identifiers.org/ec-code/4.3.2.2
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
is described by: ECO:0000269
is: SBO:0000176
name: adenylosuccinate lyase
product: MODEL1310110026#
reversible: false

metaM cholp c
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
name: choline phosphate(1-)
boundary condition: false
has only substance units: false
is: CHEBI:295975
constant: false

metaM trdrd c
is: SBO:0000247
boundary condition: false
type: Species
constant: false
name: Reduced thioredoxin
is: CHEBI:15967
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
initial amount: NaN
is: C00342
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110026#_218ee7b6_42de_4d99_9324_ffb3fa02155e
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
constant: false
is: P05091
initial amount: NaN
name: ALDH2
is encoded by: hsa:217
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110026#_2dbb64c5_48ac_483c_bcad_b6a7cf57e36c
type: Species
is encoded by: hsa:79695
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: Q8IXK2
name: GALNT12
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_48d183d3_78cc_4d24_a9c6_4c071628b854
is encoded by: hsa:9583
constant: false
is: Q9Y227
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: ENTPD4

http://identifiers.org/biomodels.db/MODEL1310110026#_35abdf28_52e3_4046_b227_6d30cf8b2824
has only substance units: false
name: _AI972237_1_c
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:AI972237
boundary condition: true

metaR CHOLtu
product: MODEL1310110026#
fast: false
is: SBO:0000185
reactant: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
reversible: true
name: Choline uniport
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
modifier: MODEL1310110026#

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

metaM dump m
name: dUMP(2-)
is: CHEBI:246422
is: SBO:0000247
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
has only substance units: false
type: Species
constant: false
is: HMDB01409
boundary condition: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110026#_252347e5_939c_4d51_a6d8_79d0735b15a6
constant: false
name: NT5C2
initial concentration: NaN
boundary condition: true
is encoded by: hsa:22978
initial amount: NaN
is: SBO:0000252
type: Species
is: P49902
has only substance units: false

metaM dopa c
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
boundary condition: false
name: dopaminium(1+)
is: CHEBI:59905
is: HMDB00073
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species

metaM tsul m
constant: false
is: SBO:0000247
is: HMDB00257
initial concentration: 1.0
type: Species
initial amount: NaN
name: thiosulfate(2-)
is: CHEBI:16094
boundary condition: false
has only substance units: false
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320

metaR PYDXNtr
product: MODEL1310110026#
type: Reaction
name: pyridoxine transport via diffusion
fast: false
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6380540 NOTES:IT
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
is described by: ECO:0000000

metaM din c
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:28997
name: Deoxyinosine
has only substance units: false
is: SBO:0000247
is: C05512
constant: false
type: Species
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
is: HMDB00071

http://identifiers.org/biomodels.db/MODEL1310110026#_61847e1f_823e_4109_8de1_59b8f80701b8
constant: false
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
name: _AI824319_1_r
is: SBO:0000252
is encoded by: hsa:AI824319
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_9894dbaf_bfdc_4a77_a970_5009fc6faf1a
is: B4E097
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2592
name: GALT

metaM din e
initial concentration: 1.0
initial amount: NaN
name: Deoxyinosine
is: SBO:0000247
is: C05512
has only substance units: false
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
constant: false
is: CHEBI:28997
boundary condition: false
type: Species
is: HMDB00071

http://identifiers.org/biomodels.db/MODEL1310110026#_ceab25db_3487_4999_9bc4_0f3e4d63faec
has only substance units: false
name: _AI601100_1_m
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AI601100
constant: false
type: Species

metaM betald c
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
name: betaine aldehyde
is: SBO:0000247
is: CHEBI:15710
is: HMDB01252
constant: false
initial concentration: 1.0

metaM mi145p c
has only substance units: false
is: CHEBI:203600
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
name: 1D-myo-inositol 1,4,5-trisphosphate(6-)
boundary condition: false
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1 EHMN_ABBREVIATION: C01245
is: HMDB01498
constant: false

metaM strdnccoa m
initial amount: NaN
initial concentration: 1.0
is: C16163
type: Species
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205473
constant: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
is: HMDB06519
is: SBO:0000247
name: stearidonyl coenzyme A

http://identifiers.org/biomodels.db/MODEL1310110026#_45b54eaf_f334_49e0_b7db_da2b02934948
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is: Q9NQU1
is encoded by: hsa:65010
name: SLC26A6
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaM ksi pre13 g
constant: false
initial concentration: 1.0
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 13
is: CHEBI:58053
is: C00130
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C143H231N10O111S3X CHARGE: -4
has only substance units: false
is: HMDB00175

metaM dtdp e
type: Species
is: CHEBI:58369
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB01274
boundary condition: false

metaR MAN6PI
reactant: MODEL1310110026#
type: Reaction
is described by: ECO:0000304
name: mannose-6-phosphate isomerase
is version of: http://identifiers.org/ec-code/5.3.1.8
reversible: true
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110026#
modifier: MODEL1310110026#
fast: false
kinetic law: MODEL1310110026#
is: SBO:0000176

metaR EX pectintchol LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pectin-taurocholic acid complex
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_539c5f3a_864c_4c4f_bb55_dcdc812e5cdd
initial amount: NaN
is encoded by: hsa:1603
is encoded by: hsa:6184
has part: P04843
type: Species
has part: Q53G02
constant: false
has only substance units: false
name: DAD1:DDOST:RPN1:RPN2
has part: P39656
initial concentration: NaN
has part: P04844
boundary condition: true
is encoded by: hsa:6185
is encoded by: hsa:1650
is: SBO:0000297

metaR NDPK9n
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear
fast: false
modifier: MODEL1310110026#
product: MODEL1310110026#
is: SBO:0000176
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_6b9cf48d_9a2a_4adf_b69c_060f745a4bfc
initial amount: NaN
type: Species
has only substance units: false
is: O95479
constant: false
initial concentration: NaN
name: H6PD
is: SBO:0000252
is encoded by: hsa:9563
boundary condition: true

metaR LPS3e
reversible: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110026#
name: lipase, extracellular
reactant: MODEL1310110026#
fast: false
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.1.1.3
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.23 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:NJ
product: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_82b7cf98_744d_44a4_8373_37f5e9be4336
initial concentration: NaN
type: Species
has only substance units: false
is: A5PKZ1
is: SBO:0000252
is encoded by: hsa:11227
constant: false
name: GALNT5
initial amount: NaN
boundary condition: true

metaM 3sala m
has only substance units: false
is: SBO:0000247
constant: false
name: 3-sulfino-L-alanine (1-)
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C3H5NO4S CHARGE: -2 INCHI: InChI=1S/C3H7NO4S/c4-2(3(5)6)1-9(7)8/h2H,1,4H2,(H,5,6)(H,7,8)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
boundary condition: false
is: CHEBI:61085
is: C00606

metaM dopa e
boundary condition: false
is: CHEBI:59905
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
name: dopaminium(1+)
is: HMDB00073
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species

metaM dag hs c
name: diglyceride
initial concentration: 1.0
type: Species
is: CHEBI:18035
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN

metaM h2o l
initial amount: NaN
is: HMDB02111
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:15377
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
name: water

http://identifiers.org/biomodels.db/MODEL1310110026#_1b475f5e_9a01_4470_b7c8_9948135876e2
constant: false
is: Q9Y2C5
has only substance units: false
is encoded by: hsa:10050
initial concentration: NaN
type: Species
boundary condition: true
name: SLC17A4
initial amount: NaN
is: SBO:0000252

metaR UGALNACtg
fast: false
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
is described by: ECO:0000269
name: UDP-GalNAc Golgi transport via CMP antiport
reactant: MODEL1310110026#
product: MODEL1310110026#
kinetic law: MODEL1310110026#
is: SBO:0000185
modifier: MODEL1310110026#
reversible: true
type: Reaction

metaR 4HBZCOAFm
fast: false
is described by: ECO:0000000
reactant: MODEL1310110026#
product: MODEL1310110026#
is: SBO:0000176
type: Reaction
name: 4-hydroxybenzoyl-CoA formation
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
kinetic law: MODEL1310110026#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110026#_8cd5f8a4_f804_463f_8039_8ef4794e11db
initial amount: NaN
is encoded by: hsa:23761
boundary condition: true
is: Q9UG56
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
name: PISD
constant: false

metaM dump n
boundary condition: false
is: CHEBI:246422
initial concentration: 1.0
is: SBO:0000247
name: dUMP(2-)
has only substance units: false
constant: false
type: Species
is: HMDB01409
initial amount: NaN
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365

http://identifiers.org/biomodels.db/MODEL1310110026#_410e9d48_678c_4ab4_8fab_b771adef89c9
constant: false
has part: Q6I9V2
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:509
boundary condition: true
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
is: SBO:0000297
is encoded by: hsa:498
has part: P25705
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_ca3dfd2b_cd98_492f_89c8_048e3e1be931
initial concentration: NaN
name: SLC34A2
has only substance units: false
is: O95436
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:10568
constant: false

metaR 34DHPHELAT1tc
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3,4-Dihydroxy-L-phenylalanine by LAT1 in association with 4F2hc, across the apical surface of the memebranes.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_2a036aaf_1d5c_4744_8c96_418a20a8cf73
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:2182
initial concentration: NaN
is: SBO:0000252
is: Q5JWV8
name: ACSL4
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_709e4fb9_aefa_4c57_b7f8_1ba6d8625018
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:W87865
name: _W87865_1_c
initial concentration: NaN

metaR RE1447M
reversible: true
product: MODEL1310110026#
reactant: MODEL1310110026#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
name: RE1447
type: Reaction
kinetic law: MODEL1310110026#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.41
modifier: MODEL1310110026#

metaR CHOLtn
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
product: MODEL1310110026#
fast: false
name: Choline transport, nuclear through pores
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110026#_f40e98f6_c6bd_4d9f_a1e6_fbdf666ae9a7
has only substance units: false
constant: false
is encoded by: hsa:1719
type: Species
is: P00374
boundary condition: true
is: SBO:0000252
name: DHFR
initial concentration: NaN
initial amount: NaN

metaM dag hs e
is: CHEBI:18035
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
name: diglyceride
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false

metaR C12DCACOT
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of dodecanedioyl coa for release into cytosol
type: Reaction

metaM h g
type: Species
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial amount: NaN
name: proton
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:24636

http://identifiers.org/biomodels.db/MODEL1310110026#_a61f3d0c_2e75_4ecb_bf8c_2d79a70bc2d1
type: Species
constant: false
boundary condition: true
is: P49247
is: SBO:0000252
is encoded by: hsa:22934
initial concentration: NaN
initial amount: NaN
name: RPIA
has only substance units: false

metaR Htr
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
product: MODEL1310110026#
reversible: true
fast: false
is: SBO:0000185
name: H transporter, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ

http://identifiers.org/biomodels.db/MODEL1310110026#_77839583_b90d_4195_bf2b_27ab9ceeec7c
boundary condition: true
is: B7Z3K8
name: COQ6
has only substance units: false
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:51004
initial concentration: NaN

metaR NDPK2
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110026#
is described by: ECO:0000269
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
name: nucleoside-diphosphate kinase (ATP:UDP)
type: Reaction
product: MODEL1310110026#
reversible: true
is: SBO:0000176

metaR EX elaid LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: elaidic acid exchange
type: Reaction

metaR ITPtn
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110026#
reversible: true
name: ITP nuclear transport
is: SBO:0000185
fast: false
is described by: ECO:0000000
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#

metaM h2o e
is: HMDB02111
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: C00001
is: CHEBI:15377
initial concentration: 1.0
initial amount: NaN
name: H2O

metaR RE1447N
product: MODEL1310110026#
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
reactant: MODEL1310110026#
name: RE1447
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reversible: true

metaR MMSAD1m
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
name: methylmalonate-semialdehyde dehydrogenase
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093 NOTES:TV Also converts propanal to propanoyl-CoA
is version of: http://identifiers.org/ec-code/1.2.1.27
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110026#
reversible: false
fast: false
is: SBO:0000176

metaR PYK
type: Reaction
kinetic law: MODEL1310110026#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.40
reactant: MODEL1310110026#
fast: false
name: pyruvate kinase
product: MODEL1310110026#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5315.2) or (5313.2) or (5315.3) or (5313.1) or (113452.1) or (5315.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000134
modifier: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_3fcb1829_6c6e_42b1_9caf_d6b4758dd1c1
initial concentration: NaN
boundary condition: true
name: _AI348006_1_c
is: SBO:0000252
is encoded by: hsa:AI348006
initial amount: NaN
has only substance units: false
type: Species
constant: false

metaM udpacgal g
boundary condition: false
constant: false
is: HMDB00304
is: CHEBI:57847
name: UDP-N-acetyl-D-galactosamine(2-)
has only substance units: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_b9d6dfea_3f44_47ff_b2f1_6c3a2cb7bc0e
is: Q99643
type: Species
is encoded by: hsa:6391
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: SDHC

metaM dpcoa m
has only substance units: false
boundary condition: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
initial concentration: 1.0
is: HMDB01373
is: SBO:0000247
is: CHEBI:57328
type: Species
name: 3'-dephospho-CoA(2-)
initial amount: NaN
constant: false

metaR NDPK1
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: nucleoside-diphosphate kinase (ATP:GDP)
type: Reaction
is described by: ECO:0000134
modifier: MODEL1310110026#
product: MODEL1310110026#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110026#

metaM ksii core2 pre2 g
has only substance units: false
boundary condition: false
type: Species
constant: false
is: C00130
is: SBO:0000247
notes: FORMULA: C39H63N3O28X CHARGE: -1
is: HMDB00175
is: CHEBI:58053
initial amount: NaN
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 2

metaR GLYCtm
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
reactant: MODEL1310110026#
type: Reaction
is described by: ECO:0000000
name: glycerol transport
kinetic law: MODEL1310110026#
product: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_df53f270_b45e_4b80_9c20_f45665fd2519
is encoded by: hsa:9187
name: SLC24A1
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
type: Species
is: B4DUG1
initial amount: NaN

metaR r0680
type: Reaction
modifier: MODEL1310110026#
is described by: ECO:0000000
reactant: MODEL1310110026#
reversible: true
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is version of: http://identifiers.org/ec-code/2.3.1.137
product: MODEL1310110026#
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
is: SBO:0000176
fast: false

metaR NDPK4
modifier: MODEL1310110026#
is described by: ECO:0000269
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
name: nucleoside-diphosphate kinase (ATP:dTDP)
type: Reaction
kinetic law: MODEL1310110026#
product: MODEL1310110026#
is: SBO:0000176
reversible: true

metaR CBR2
is version of: http://identifiers.org/ec-code/1.1.1.189
name: Carbonyl reductase [NADPH] 1
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reversible: false
notes: GENE_ASSOCIATION: (873.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.197 Confidence Level: 4 AUTHORS: PMID:8740524,PMID:9740676 NOTES:multiple EC EC 1.1.1.189 EC 1.1.1.197 NJ
modifier: MODEL1310110026#
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110026#
is described by: ECO:0000269

metaM nrvnccoa c
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
name: nervonyl coenzyme A
is: SBO:0000247
has only substance units: false
is: C16532
notes: FORMULA: C45H76N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H80N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h11-12,32-34,38-40,44,55-56H,4-10,13-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b12-11-/t34-,38-,39-,40?,44-/m1/s1
initial amount: NaN

metaM tsul c
initial amount: NaN
is: HMDB00257
constant: false
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
is: CHEBI:16094
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
name: thiosulfate(2-)

metaM dcacoa m
name: Decanoyl-CoA (n-C10:0CoA)
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: CHEBI:61430
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
boundary condition: false
is: C05274
is: HMDB06404
initial concentration: 1.0
is: SBO:0000247

metaR UMPKn
reversible: true
product: MODEL1310110026#
name: UMP kinase, nuclear
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
fast: false

metaR TETHEX3t
reactant: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
reversible: true
product: MODEL1310110026#
name: fatty acid transport via diffusion
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110026#

metaM Rtotal2coa c
initial amount: NaN
constant: false
type: Species
has only substance units: false
name: R total 2 coenzyme A
is: CHEBI:60377
boundary condition: false
is: C00055
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4
is: HMDB00095
initial concentration: 1.0
is: SBO:0000247

metaM lneldccoa c
notes: FORMULA: C39H62N7O17P3S CHARGE: -4
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB06521
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/9543677
constant: false
name: linoelaidyl coenzyme A

metaM h2o g
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: HMDB02111
constant: false
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:15377
name: water
initial concentration: 1.0

metaM dtdp c
boundary condition: false
is: HMDB01274
is: C00363
is: SBO:0000247
name: dTDP
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
has only substance units: false
constant: false
is: CHEBI:58369
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_592d9a78_f272_4b82_9d15_6e61185e7c7f
is encoded by: hsa:5296
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: O00459
name: PIK3R2
initial concentration: NaN

metaM ksi pre30 g
boundary condition: false
is: HMDB00175
is: C00130
is: CHEBI:58053
type: Species
notes: FORMULA: C219H350N15O184S9X CHARGE: -10
initial concentration: 1.0
constant: false
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 30
has only substance units: false
is: SBO:0000247

metaR NDPK3
name: nucleoside-diphosphate kinase (ATP:CDP)
notes: GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
is: SBO:0000176
fast: false
modifier: MODEL1310110026#
product: MODEL1310110026#

metaR EX vitd3 LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for calctriol
type: Reaction

metaR EX 4mop LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-methyl-2-oxopentanoate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_90da5225_fa98_493c_96df_a0e9252bd75f
initial concentration: NaN
name: ALG12
is: Q9BV10
boundary condition: true
type: Species
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:79087
is: SBO:0000252

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_10f5832c_74f8_4027_b3fc_43d00030c027
boundary condition: true
is encoded by: hsa:6549
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
name: SLC9A2
is: Q9UBY0

metaR ENGASE3ly
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110026#
type: Reaction
product: MODEL1310110026#
name: endo-beta-N-acetylglucosaminidase, lysosomal
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110026#

metaM mi14p c
boundary condition: false
is: HMDB00968
is: CHEBI:58282
initial amount: NaN
has only substance units: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate

metaR sink dd2coa LPAREN c RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: DD2COASINK
type: Reaction

metaR G14T5g
product: MODEL1310110026#
is described by: ECO:0000000
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110026#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.2) or (8704.1) or (8703.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38

http://identifiers.org/biomodels.db/MODEL1310110026#_3366731c_59b3_4933_8c19_29553520000a
boundary condition: true
type: Species
initial amount: NaN
is: B2RAT6
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2592
constant: false
name: GALT
is: SBO:0000252

metaM acmana e
is: SBO:0000247
type: Species
is: CHEBI:17122
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
is: HMDB01129
has only substance units: false
name: N-acetyl-D-mannosamine
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN

metaR PGK
kinetic law: MODEL1310110026#
type: Reaction
name: phosphoglycerate kinase
modifier: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: (5230.1) or (375056.1) or (5232.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176
product: MODEL1310110026#
is described by: ECO:0000134
reversible: true
is version of: http://identifiers.org/ec-code/2.7.2.3
reactant: MODEL1310110026#

metaR r0686
product: MODEL1310110026#
is described by: ECO:0000000
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.3.2.2
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
modifier: MODEL1310110026#
is: SBO:0000176
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110026#

metaM tsul e
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
is: HMDB00257
is: SBO:0000247
has only substance units: false
is: CHEBI:16094
constant: false
name: thiosulfate(2-)
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species

metaR NDPK6
name: Nucleoside-diphosphate kinase (ATP:dUDP)
kinetic law: MODEL1310110026#
product: MODEL1310110026#
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110026#
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110026#_c7fd067a_74fb_4365_bca5_ccb30d40a539
name: GGT5
is encoded by: hsa:2687
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
constant: false
is: P36269
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_5c903918_2a8b_4172_9d2e_fbad435ab06a
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
name: PDE8A
has only substance units: false
type: Species
is encoded by: hsa:5151
is: H0YMZ7
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110026#_4957a117_c731_4412_8496_e84e862f77dd
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:122622
initial amount: NaN
name: ADSSL1
is: B3KTV4
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_0f48d0ee_a0b1_4ecc_9464_dc068ce7851e
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
name: AGPAT3
is: Q9NRZ7
type: Species
constant: false
is encoded by: hsa:56894

metaR NDPK5
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
type: Reaction
name: Nucleoside-diphosphate kinase (ATP:dGDP)
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
fast: false
modifier: MODEL1310110026#
is: SBO:0000176

metaM udpacgal c
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
initial amount: NaN
is: HMDB00304
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
name: UDP-N-acetyl-D-galactosamine(2-)
constant: false
is: SBO:0000247
is: CHEBI:57847

http://identifiers.org/biomodels.db/MODEL1310110026#_199cd218_da96_4c7e_a09a_0d44fc5071a7
name: _AA526438_1_m
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:AA526438

metaM h e
is: C00080
is: CHEBI:24636
type: Species
boundary condition: false
constant: false
name: proton
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: "
is: http://identifiers.org/pubchem.compound/3380

http://identifiers.org/biomodels.db/MODEL1310110026#_6ff89a52_ba43_46d0_a033_65aa13691692
is encoded by: hsa:57835
type: Species
has only substance units: false
name: SLC4A5
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
is: Q9BY07
boundary condition: true

metaR CSAPASEly
product: MODEL1310110026#
kinetic law: MODEL1310110026#
type: Reaction
is described by: ECO:0000000
name: chondroitin sulfate A proteoglycan protease, lysosome (endosome)
is: SBO:0000176
fast: false
reversible: false
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD

metaR DOLPH Uer
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.3.51 Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:
product: MODEL1310110026#
reactant: MODEL1310110026#
reversible: false
kinetic law: MODEL1310110026#
name: Dolichol-phosphate phosphohydrolase, human (uterus)
fast: false
is: SBO:0000176
is described by: ECO:0000000

metaR 5MTHFt
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
is described by: ECO:0000269
modifier: MODEL1310110026#
reactant: MODEL1310110026#
type: Reaction
product: MODEL1310110026#
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
kinetic law: MODEL1310110026#
fast: false
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110026#_8a0ff836_0438_4203_b915_e4b0753568d4
is: P42765
type: Species
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:10449
name: ACAA2
has only substance units: false
initial concentration: NaN

metaR PYRt2m
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD
name: pyruvate mitochondrial transport via proton symport
modifier: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000

metaR ACGPID
modifier: MODEL1310110026#
reversible: false
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.89
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
type: Reaction
notes: GENE_ASSOCIATION: (9487.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.5.1.89 Confidence Level: 4 AUTHORS: PMID:10085243,PMID:14742432 NOTES:NCD
is described by: ECO:0000269
name: N-acetylglucosaminylphosphatidylinositol deacetylase
product: MODEL1310110026#

metaR PGI
is version of: http://identifiers.org/ec-code/5.3.1.9
modifier: MODEL1310110026#
reactant: MODEL1310110026#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:
product: MODEL1310110026#
name: glucose-6-phosphate isomerase
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110026#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110026#_3bbfa049_d9b0_4654_b400_b2f1804ea2f4
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: ATP1B2
constant: false
is: P14415
is encoded by: hsa:482

metaM gullac c
name: L-gulono-1,4-lactone
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C6H10O6 CHARGE: 0 INCHI: InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3+,4-,5+/m0/s1
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB03466
initial amount: NaN
is: CHEBI:17587

metaR NDPK8
product: MODEL1310110026#
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
name: Nucleoside-diphosphate kinase (ATP:dADP)
fast: false

metaR Htx
name: H transporter, peroxisome
reactant: MODEL1310110026#
type: Reaction
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
kinetic law: MODEL1310110026#
product: MODEL1310110026#
is described by: ECO:0000000

metaM xol7a r
initial amount: NaN
constant: false
is: HMDB01496
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C03594
has only substance units: false
initial concentration: 1.0
is: CHEBI:1296
boundary condition: false
name: 20-hydroxycholesterol
is: SBO:0000247
type: Species

metaR EX imp LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IMP exchange
type: Reaction

metaM h2o c
notes: FORMULA: H2O CHARGE: 0
is: C00001
type: Species
is: CHEBI:3303
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB02111
name: H2O
initial amount: NaN
constant: false
is: SBO:0000247

metaM dgpi prot hs r
initial amount: NaN
name: deacylated-glycophosphatidylinositol (GPI)-anchored protein
is: SBO:0000247
is: HMDB02925
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C39H76N4O37P4FULLRCO2FULLR2CO2X CHARGE: 0
is: CHEBI:53486

metaR EX pect LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pectins
type: Reaction

metaR PPD2CSPp
fast: false
is described by: ECO:0000000
product: MODEL1310110026#
name: PPD2CSPp
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:spontaneous cyclization reaction MM
reactant: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#

metaR CYTDK1
is described by: ECO:0000254
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.48
is: SBO:0000176
kinetic law: MODEL1310110026#
type: Reaction
fast: false
name: ATPcytidine 5-phosphotransferase
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110026#
product: MODEL1310110026#

metaR r0683
fast: false
kinetic law: MODEL1310110026#
type: Reaction
reversible: false
reactant: MODEL1310110026#
is described by: ECO:0000000
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
modifier: MODEL1310110026#
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176

metaM h c
notes: FORMULA: H CHARGE: 1 INCHI: "
has only substance units: false
is: C00080
type: Species
is: http://identifiers.org/pubchem.compound/3380
initial amount: NaN
is: CHEBI:24636
initial concentration: 1.0
constant: false
name: proton
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110026#_7b787184_6934_4ad0_880d_15d52255bde8
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:50700
boundary condition: true
is: Q9NYR8
name: RDH8
initial amount: NaN
has only substance units: false

metaR MECOALm
fast: false
product: MODEL1310110026#
is: SBO:0000176
is described by: ECO:0000212
is version of: http://identifiers.org/ec-code/6.2.1.4
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
is version of: http://identifiers.org/ec-code/6.2.1.5
modifier: MODEL1310110026#
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: true
type: Reaction

metaR NDPK7
fast: false
reversible: true
product: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
is described by: ECO:0000269
name: nucleoside-diphosphate kinase (ATP:dCDP)
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110026#
modifier: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_96835c1a_4350_4cf8_a5bc_abfb7f59ae11
is: SBO:0000252
is encoded by: hsa:249
initial amount: NaN
type: Species
constant: false
name: ALPL
initial concentration: NaN
is: B7Z4Y6
has only substance units: false
boundary condition: true

metaM cs a deg5 l
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 5
initial amount: NaN
is: CHEBI:15936
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C23H36O24S CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110026#_76f17fdf_4ac6_4e0f_abff_7eb30725abbe
initial amount: NaN
initial concentration: NaN
name: NDUFB10
boundary condition: true
type: Species
is encoded by: hsa:4716
is: SBO:0000252
is: A8K761
constant: false
has only substance units: false

metaR r1567
kinetic law: MODEL1310110026#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110026#
reversible: true
fast: false
product: MODEL1310110026#

metaR PI4PP
is: SBO:0000176
name: phosphatidylinositol-4-phosphate 4-phosphatase
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2425833 NOTES:NCD
product: MODEL1310110026#
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: false

metaM 3hmbcoa m
is: HMDB01356
type: Species
has only substance units: false
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
constant: false
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57312
boundary condition: false

metaR NACHEXA11ly
is described by: ECO:0000000
kinetic law: MODEL1310110026#
fast: false
type: Reaction
is: SBO:0000176
reversible: false
name: beta-N-acetylhexosaminidase A, lysosomal
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
product: MODEL1310110026#
reactant: MODEL1310110026#

metaM succ m
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: CHEBI:30031
is: C00042
is: SBO:0000247
is: HMDB00254
has only substance units: false
constant: false
type: Species
name: Succinate
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaR r1755
reversible: false
reactant: MODEL1310110026#
product: MODEL1310110026#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110026#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaR r1642
is described by: ECO:0000000
reactant: MODEL1310110026#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110026#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110026#
type: Reaction

metaM thcholstoic x
initial concentration: 1.0
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
is: CHEBI:18402
boundary condition: false
is: HMDB03873
initial amount: NaN
type: Species
has only substance units: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
constant: false
is: SBO:0000247

metaM 3dsphgn c
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17,20H,2-16,19H2,1H3/p+1/t17-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01019 EHMN_ABBREVIATION: C02934
type: Species
is: HMDB01480
has only substance units: false
boundary condition: false
is: CHEBI:58299
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
name: (2S)-1-hydroxy-3-oxooctadecan-2-aminium

metaM sucr e
initial concentration: 1.0
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00091 EHMN_ABBREVIATION: C00089
is: CHEBI:17992
is: C00089
is: HMDB00258
constant: false
initial amount: NaN
has only substance units: false
type: Species
name: Sucrose
boundary condition: false
is: SBO:0000247

metaR r1566
type: Reaction
product: MODEL1310110026#
kinetic law: MODEL1310110026#
fast: false
reversible: true
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM pap c
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
is: HMDB00061
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:58343
has only substance units: false
boundary condition: false
name: adenosine 3',5'-bismonophosphate(4-)
type: Species
is: SBO:0000247

metaR PPPG9tm
kinetic law: MODEL1310110026#
reversible: true
name: protoporphyrinogen IX mitochondrial transport
is described by: ECO:0000000
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:14623258 NOTES:NCD. Benzodiazepine receptor PBR see also 17168567

metaR S6T1g
is described by: ECO:0000000
product: MODEL1310110026#
kinetic law: MODEL1310110026#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
type: Reaction
fast: false
modifier: MODEL1310110026#
reversible: false
reactant: MODEL1310110026#

metaM lac L x
has only substance units: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
name: (S)-lactate
is: HMDB00190
is: SBO:0000247
is: CHEBI:16651
initial amount: NaN
type: Species
constant: false
boundary condition: false
initial concentration: 1.0

metaM acgal1p c
is: SBO:0000247
is: HMDB06480
has only substance units: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6+,7-,8?/m1/s1
initial amount: NaN
is: CHEBI:55404
name: N-Acetyl-D-galactosamine 1-phosphate
boundary condition: false
type: Species
constant: false
initial concentration: 1.0

metaR DOLPMT1 Uer
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
modifier: MODEL1310110026#
reversible: false
product: MODEL1310110026#
type: Reaction
fast: false
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.4.1.258
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (10195.4) or (10195.1) or (10195.3) or (10195.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD

metaR G14T10g
product: MODEL1310110026#
fast: false
reactant: MODEL1310110026#
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8703.1) or (8704.2) or (8704.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
modifier: MODEL1310110026#
is described by: ECO:0000000
kinetic law: MODEL1310110026#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.90

http://identifiers.org/biomodels.db/MODEL1310110026#_c5cd6d80_b73f_4766_a55c_61e1d961506b
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
type: Species
name: _AA419122_1_c
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AA419122

metaR r0377
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.7.4.3
fast: false
is: SBO:0000176
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110026#
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
type: Reaction
kinetic law: MODEL1310110026#

metaR r1641
reactant: MODEL1310110026#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110026#
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110026#_5318ec09_2cd6_4322_9eea_3f352797ec2f
name: ATP5G3
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:518

metaR 3MOBt2im
name: 3-methyl-2-oxobutanoate mitochondrial transport via proton symport
product: MODEL1310110026#
reversible: false
kinetic law: MODEL1310110026#
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
reactant: MODEL1310110026#
is: SBO:0000185

metaR EX glgchlo LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for beta glucan-glycocholate complex
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_cf5642f8_2573_49e1_aa79_b1758f476792
name: MTMR3
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:8897
has only substance units: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110026#_4cc30b59_e9e2_4f6b_8b4f_74867d32600f
boundary condition: true
type: Species
constant: false
name: SYNJ1
has only substance units: false
is: SBO:0000252
is: O43426
initial amount: NaN
is encoded by: hsa:8867
initial concentration: NaN

metaR r1640
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
modifier: MODEL1310110026#
product: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: true
reactant: MODEL1310110026#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR THP2Ctp
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
reversible: true
kinetic law: MODEL1310110026#
type: Reaction
fast: false
product: MODEL1310110026#
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate transport, peroxisomal
is: SBO:0000185
is described by: ECO:0000000

metaR r1569
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110026#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110026#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110026#

metaR COAtn
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110026#
name: coenzyme A transport, nuclear
type: Reaction
product: MODEL1310110026#

metaR STCOAtx
product: MODEL1310110026#
name: fatty acid intracellular transport
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
fast: false
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_8644da24_dd5b_41c3_8152_ca71ef4e8559
has only substance units: false
is encoded by: hsa:10087
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
is: Q9Y5P4
initial concentration: NaN
name: COL4A3BP
boundary condition: true

metaR r1568
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110026#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110026#
reversible: true
is: SBO:0000185
reactant: MODEL1310110026#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR CRNtx
reversible: true
kinetic law: MODEL1310110026#
product: MODEL1310110026#
name: carnitine transport peroxisome to mitochondria
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12814641,PMID:15464416 NOTES:mechanism not currently elucidated NJ
fast: false
is: SBO:0000185

metaM CE4876 r
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876
type: Species
has only substance units: false
is: CHEBI:57923
constant: false
name: delta12-Prostaglandin J2

metaR LEUGLYPEPT1tc
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylglycine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaM no e
is: HMDB03378
initial concentration: 1.0
name: Nitric oxide
type: Species
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:16480
is: SBO:0000247
is: C00533

metaR GALASE14ly
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110026#
name: beta-galactosidase, lysosomal
modifier: MODEL1310110026#
reversible: false
reactant: MODEL1310110026#
is described by: ECO:0000000
product: MODEL1310110026#
fast: false

metaM arachdcoa x
is: SBO:0000247
type: Species
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
has only substance units: false
name: arachidonoyl-CoA(4-)
is: CHEBI:57368
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB06523

metaM dd2coa c
has only substance units: false
name: trans-Dodec-2-enoyl-CoA
is: HMDB03712
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4

metaR NACHEX27ly
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12562784 NOTES:NCD
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110026#
fast: false
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110026#
reactant: MODEL1310110026#

metaM g1p c
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
is: C00103
name: D-Glucose 1-phosphate
is: HMDB01586
has only substance units: false
is: CHEBI:58601
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

metaR PYDAMK
reversible: false
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (8566.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
fast: false
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000269
is: SBO:0000176
name: pyridoxamine kinase
is version of: http://identifiers.org/ec-code/2.7.1.35
modifier: MODEL1310110026#

metaR CYTK9n
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110026#
is described by: ECO:0000269
reversible: true
product: MODEL1310110026#
modifier: MODEL1310110026#
name: cytidylate kinase (CMP,dCTP),nuclear
is: SBO:0000176
reactant: MODEL1310110026#
fast: false

metaR COAtm
product: MODEL1310110026#
reversible: true
fast: false
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
name: CoA transporter
modifier: MODEL1310110026#
is: SBO:0000185
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110026#_4dd27307_9ef2_4d5b_86b3_b47f52c67204
is: SBO:0000252
initial concentration: NaN
is: O00330
has only substance units: false
boundary condition: true
constant: false
type: Species
is encoded by: hsa:8050
name: PDHX
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_65c5e107_9d1b_4b76_a423_cc75baad8cc4
is encoded by: hsa:114
name: ADCY8
initial concentration: NaN
boundary condition: true
constant: false
is: Q4F7X0
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_f4d01925_926b_4e32_b592_efe5f46ea83c
boundary condition: true
is: P32322
constant: false
type: Species
has only substance units: false
is encoded by: hsa:5831
name: PYCR1
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaM acnam l
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
name: N-acetylneuraminate
is: HMDB00230
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
boundary condition: false
is: CHEBI:35418
is: SBO:0000247
type: Species

metaR EX 3mop LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxopentanoate
type: Reaction

metaR r1563
type: Reaction
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
is described by: ECO:0000000
fast: false
product: MODEL1310110026#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaR SEBCOAPET
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of sebacoylcoa for release into cytosol
type: Reaction

metaR r1418
product: MODEL1310110026#
is: SBO:0000176
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
fast: false
reactant: MODEL1310110026#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
reversible: true
kinetic law: MODEL1310110026#

metaM HC01434 x
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58931
is: SBO:0000247
type: Species
has only substance units: false
name: oxalatosuccinate(3-)
boundary condition: false
constant: false
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379

http://identifiers.org/biomodels.db/MODEL1310110026#_49c2b068_6db7_4a92_918e_7ca8346ce3d6
has only substance units: false
is: Q0VAA5
name: PLCXD2
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is encoded by: hsa:257068
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_c9b4d5ea_a8b5_42ed_9500_782a856a3de6
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: P49748
initial concentration: NaN
name: ACADVL
is encoded by: hsa:37
constant: false
type: Species

metaR COAtp
product: MODEL1310110026#
is described by: ECO:0000000
reactant: MODEL1310110026#
fast: false
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: coenzyme A transport, peroxisomal
type: Reaction
reversible: true
is: SBO:0000185

metaM ksi pre17 g
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 17
initial amount: NaN
type: Species
notes: FORMULA: C157H252N11O127S5X CHARGE: -6
constant: false
boundary condition: false
is: CHEBI:28067

metaR r1758
fast: false
is: SBO:0000185
modifier: MODEL1310110026#
type: Reaction
product: MODEL1310110026#
reversible: false
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110026#

metaM pap g
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
initial concentration: 1.0
constant: false
is: HMDB00061
name: adenosine 3',5'-bismonophosphate(4-)
is: CHEBI:58343
initial amount: NaN

metaR G14T6g
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110026#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110026#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38
modifier: MODEL1310110026#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110026#

metaM so3 c
is: C00094
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
is: SBO:0000247
constant: false
is: HMDB00240
boundary condition: false
name: Sulfite
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:17137

metaR r1562
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
reversible: true
product: MODEL1310110026#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185

metaM pro L m
name: L-proline
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:17203
initial concentration: 1.0
boundary condition: false
is: HMDB00162
constant: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145

metaR DHDPBMTm
is version of: http://identifiers.org/ec-code/2.1.1.114
name: dihydroxydecaprenylbenzoate methyltransferase
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110026#
reversible: false
product: MODEL1310110026#
modifier: MODEL1310110026#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51805.1) SUBSYSTEM: Ubiquinone synthesis EC Number: 2.1.1.114 Confidence Level: 4 AUTHORS: PMID:10777520,PMID:1965190,PMID:7380842 NOTES:Used to make Ubiquinone-10 EC 2.1.1.114 IT
reactant: MODEL1310110026#

metaR CRNrtx
type: Reaction
reactant: MODEL1310110026#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: added during gap filling. NOTES:added during gap filling.
fast: false
kinetic law: MODEL1310110026#
is described by: ECO:0000134
product: MODEL1310110026#
name: reversible transport of L-Carnitine in peroxisome
reversible: true

metaM mag hs e
is: CHEBI:32391
has only substance units: false
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
is: SBO:0000247
is: HMDB03073
boundary condition: false
initial concentration: 1.0
name: monoacylglycerol 2

metaM acnam n
is: HMDB00230
initial amount: NaN
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
is: SBO:0000247
boundary condition: false
is: CHEBI:35418
type: Species
name: N-acetylneuraminate
initial concentration: 1.0
has only substance units: false
constant: false

metaM 3pg m
is: CHEBI:58272
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB00807
boundary condition: false
has only substance units: false
constant: false
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
initial concentration: 1.0

metaR CLFORtex
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (5172.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
modifier: MODEL1310110026#
reversible: false
product: MODEL1310110026#
fast: false
name: chloride transport via formate countertransport
reactant: MODEL1310110026#
type: Reaction
is described by: ECO:0000304
is: SBO:0000185

metaR r1565
type: Reaction
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110026#
reversible: true
product: MODEL1310110026#
fast: false

metaR C6DCCACT
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of adipoyl carnitine into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_da1cc2f1_2f6b_4b83_83ba_d2b7549f6bac
initial concentration: NaN
name: NDUFV3
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
type: Species
is: P56181
is encoded by: hsa:4731
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_ea7cd517_aa40_45a2_8802_0b47ad363ee6
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:9061
boundary condition: true
is: O43252
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: PAPSS1

http://identifiers.org/biomodels.db/MODEL1310110026#_fc26bc5f_0968_421a_b875_cabc6671f452
is: SBO:0000252
is encoded by: hsa:55902
initial amount: NaN
has only substance units: false
is: Q5QPH3
name: ACSS2
constant: false
type: Species
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110026#_5cdba528_c811_4bca_9ab5_20590cee3f3a
name: _AI480132_1_c
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:AI480132
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_87d2b644_0fee_4f43_bb60_08e1fae54470
boundary condition: true
type: Species
initial amount: NaN
constant: false
name: PAPSS2
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: O95340
is encoded by: hsa:9060

metaR ECOAH12m
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
modifier: MODEL1310110026#
product: MODEL1310110026#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity

metaR COAtr
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110026#
name: COA transporter, endoplasmic reticulum
product: MODEL1310110026#
fast: false
kinetic law: MODEL1310110026#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ

http://identifiers.org/biomodels.db/MODEL1310110026#_e9fb129b_411c_40e6_8dad_4c1e32a2708e
is: P16066
initial concentration: NaN
is: SBO:0000252
name: NPR1
type: Species
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:4881

metaM ksii core2 deg3 l
boundary condition: false
name: keratan sulfate II (core 2-linked), degradation product 3
notes: FORMULA: C58H94N5O46S2X CHARGE: -2
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
is: HMDB00143
initial concentration: 1.0
is: CHEBI:12936
has only substance units: false

metaR FAOXOHC16C16DCc
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(w-OHC16-->C16DC)c
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_f399474d_017f_438d_8cd1_ade88932ad95
is: Q7GXY8
boundary condition: true
is: SBO:0000252
name: COX1
is encoded by: hsa:4512
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
constant: false

metaM HC01104 e
initial amount: NaN
name: 4-nitrophenyl phosphate(2-)
boundary condition: false
constant: false
is: CHEBI:61146
is: SBO:0000247
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
initial concentration: 1.0
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_016c0de2_1e92_4448_9c43_b049a2d1fa4c
type: Species
boundary condition: true
is: P15309
initial amount: NaN
constant: false
is encoded by: hsa:55
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: ACPP

metaM glygn4 e
notes: FORMULA: C18H31O16X CHARGE: 0
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB00122
type: Species
initial amount: NaN
name: glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})
is: CHEBI:4167
constant: false
is: SBO:0000247

metaR r1564
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: true
product: MODEL1310110026#
is: SBO:0000185
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110026#_909b2cb3_187b_42b7_8ec1_8965e8fc9aa0
initial amount: NaN
is: Q96E98
type: Species
is: SBO:0000252
is encoded by: hsa:6005
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
name: RHAG

http://identifiers.org/biomodels.db/MODEL1310110026#_86dc6430_c5df_4c01_beb7_3274d9eaaf97
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
name: _AA081045_1_c
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:AA081045

metaM phe L e
is: SBO:0000247
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
boundary condition: false
initial amount: NaN
name: L-phenylalanine
has only substance units: false
constant: false
type: Species
is: HMDB00159
initial concentration: 1.0
is: CHEBI:17295

metaR S6TASE10ly
is: SBO:0000176
is described by: ECO:0000000
name: galactose-6-sulfate sulfatase, lysosomal
fast: false
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110026#
reversible: true
type: Reaction
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110026#_5d2a5efe_da88_4a89_a46d_0a495d4607bd
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2983
has only substance units: false
boundary condition: true
constant: false
name: GUCY1B3
is: Q02153
type: Species

metaM hdcoa c
is: HMDB06532
name: Hexadecenoyl-CoA (n-C16:1CoA)
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
constant: false
boundary condition: false

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

metaR FUMtm
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV
reactant: MODEL1310110026#
modifier: MODEL1310110026#
type: Reaction
fast: false
is described by: ECO:0000269
reversible: true
name: fumarate transport, mitochondrial
is: SBO:0000185
kinetic law: MODEL1310110026#
product: MODEL1310110026#

metaR ACETONEt2m
name: acetone mitochondrial transport via proton symport
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110026#
type: Reaction
reactant: MODEL1310110026#

metaR C140CPT1
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of myristoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_11b49ecb_8841_485b_8d6e_c3b38d40f286
is: SBO:0000252
type: Species
constant: false
has only substance units: false
is encoded by: hsa:11001
is: O14975
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: SLC27A2

http://identifiers.org/biomodels.db/MODEL1310110026#_b08ddd23_4f90_467d_b974_43905c755c6c
name: GCH1
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:2643
is: Q8IZH9
boundary condition: true
is: SBO:0000252

metaR LEUPHELAT2tc
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaR FACOAL160i
notes: GENE_ASSOCIATION: (2181.2) or (22305.2) or (51703.1) or (22305.1) or (2180.1) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:1531127 NOTES:TV catalyzed by acyl-CoA synthetases
reversible: false
name: C160 fatty acid activation
fast: false
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269
modifier: MODEL1310110026#
reactant: MODEL1310110026#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110026#

metaM ksi pre28 g
boundary condition: false
notes: FORMULA: C213H341N15O176S8X CHARGE: -9
is: SBO:0000247
is: CHEBI:58053
initial amount: NaN
type: Species
is: HMDB00175
is: C00130
name: keratan sulfate I biosynthesis, precursor 28
has only substance units: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110026#_445c95e5_fe2f_45eb_8654_0fa6ab5fb7c7
constant: false
is: SBO:0000252
is: Q9NNW7
type: Species
boundary condition: true
name: TXNRD2
initial concentration: NaN
is encoded by: hsa:10587
initial amount: NaN
has only substance units: false

metaR NRVNCCOAtx
kinetic law: MODEL1310110026#
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: fatty acid intracellular transport
reactant: MODEL1310110026#
fast: false

metaR ACOAD1fm
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110026#
is: SBO:0000176
name: acyl-CoA dehydrogenase (butanoyl-CoA), mitochondrial
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (80724.1) or (36.1) or (35.1) or (34.1) or (84129.1) or (27034.1) or (28976.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.3.99.2 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:Assume NAD/NADH as acceptors Lumped long-chain acyl-CoA dehydrogenase (EC 1.3.99.13) This reaction is therefore equilivalent to trans-2-enoyl-CoA reductase (NAD) (EC 1.3.1.44)
is described by: ECO:0000269
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#

metaM cortsn r
name: cortisone
is: SBO:0000247
notes: FORMULA: C21H28O5 CHARGE: 0 INCHI: InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1 EHMN_ABBREVIATION: C00762
constant: false
has only substance units: false
is: HMDB02802
is: CHEBI:16962
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN

metaR r0494
reactant: MODEL1310110026#
is described by: ECO:0000000
type: Reaction
reversible: true
product: MODEL1310110026#
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is: SBO:0000176
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
fast: false

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

metaM arachdcoa r
name: arachidonoyl-CoA(4-)
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:57368
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
is: HMDB06523
constant: false

metaR GLUDym
type: Reaction
is described by: ECO:0000269
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
name: glutamate dehydrogenase (NADP), mitochondrial
fast: false
is version of: http://identifiers.org/ec-code/1.4.1.3
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
is: SBO:0000176
reversible: true
reactant: MODEL1310110026#

metaM ptth c
is: HMDB03426
is: SBO:0000247
name: pantetheine
initial concentration: 1.0
constant: false
is: CHEBI:16753
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831

metaM 3dpdhb me m
type: Species
notes: FORMULA: C58H87O4 CHARGE: -1 INCHI: InChI=1S/C58H88O4/c1-44(2)22-13-23-45(3)24-14-25-46(4)26-15-27-47(5)28-16-29-48(6)30-17-31-49(7)32-18-33-50(8)34-19-35-51(9)36-20-37-52(10)38-21-39-53(11)40-41-54-42-55(58(60)61)43-56(62-12)57(54)59/h22,24,26,28,30,32,34,36,38,40,42-43,59H,13-21,23,25,27,29,31,33,35,37,39,41H2,1-12H3,(H,60,61)/b45-24+,46-26+,47-28+,48-30+,49-32+,50-34+,51-36+,52-38+,53-40+
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:50776
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: 3-Decaprenyl-4-hydroxy-5-methoxybenzoate

http://identifiers.org/biomodels.db/MODEL1310110026#_80c11ea6_0283_4e9c_8d2d_80e57a857a1c
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
name: _LOC728997_1_c
initial amount: NaN
is encoded by: hsa:LOC728997
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110026#_dc85c341_a6e2_43dd_a1f4_cb43728010b1
boundary condition: true
constant: false
initial amount: NaN
is: Q92523
initial concentration: NaN
is: SBO:0000252
name: CPT1B
has only substance units: false
is encoded by: hsa:1375
type: Species

metaR COQ3m
notes: GENE_ASSOCIATION: (51805.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10777520,PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_2.1.1.114 IT
reversible: false
is described by: ECO:0000269
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
name: methyltransferase COQ3
is version of: http://identifiers.org/ec-code/2.1.1.114
product: MODEL1310110026#
modifier: MODEL1310110026#

metaM Rtotal e
is: C00255
type: Species
constant: false
initial amount: NaN
name: R total
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB00244
notes: FORMULA: CO2FULLR CHARGE: -1
is: CHEBI:3554
initial concentration: 1.0

metaR GLUPRT
is version of: http://identifiers.org/ec-code/2.4.2.14
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:
reactant: MODEL1310110026#
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
type: Reaction
is: SBO:0000176
name: glutamine phosphoribosyldiphosphate amidotransferase
fast: false
is described by: ECO:0000269
reversible: false

metaR r1649
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110026#
reversible: true
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#

metaM drib e
name: 2-deoxy-D-ribose
type: Species
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
initial concentration: 1.0
is: CHEBI:28816
is: HMDB03224
is: SBO:0000247
initial amount: NaN

metaM fad m
initial concentration: 1.0
is: CHEBI:16238
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: HMDB01248
is: SBO:0000247
type: Species
constant: false
is: C00016
has only substance units: false
boundary condition: false
initial amount: NaN
name: Flavin adenine dinucleotide oxidized

metaR P45027A11m
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.14.13.15
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ
product: MODEL1310110026#
type: Reaction
name: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase
modifier: MODEL1310110026#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110026#

metaM glcur l
boundary condition: false
initial concentration: 1.0
name: D-glucuronate
is: SBO:0000247
is: CHEBI:15748
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
constant: false
is: HMDB00127
initial amount: NaN
type: Species
has only substance units: false

metaM man6p c
initial concentration: 1.0
name: D-Mannose 6-phosphate
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
type: Species
is: HMDB01078
has only substance units: false
initial amount: NaN
is: CHEBI:17369

http://identifiers.org/biomodels.db/MODEL1310110026#_d6509fda_8fde_4c4e_871e_771db9fd4ca9
name: ALG3
initial concentration: NaN
is encoded by: hsa:10195
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
constant: false

metaR ACACt2
is described by: ECO:0000269
product: MODEL1310110026#
fast: false
type: Reaction
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
reactant: MODEL1310110026#
reversible: true
name: acetoacetate transport via proton symport
is: SBO:0000185
modifier: MODEL1310110026#

metaR r2390
fast: false
kinetic law: MODEL1310110026#
reversible: false
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
product: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185

metaR r1648
is: SBO:0000185
modifier: MODEL1310110026#
fast: false
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110026#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110026#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110026#_6fe4f39f_4bc7_48d9_b00b_5ff77440771e
initial concentration: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false
is: Q9BZW2
is encoded by: hsa:6561
is: SBO:0000252
initial amount: NaN
name: SLC13A1

http://identifiers.org/biomodels.db/MODEL1310110026#_08e8d573_59e6_4ea9_a506_b9d9620785f4
type: Species
is encoded by: hsa:492
is: SBO:0000252
constant: false
has only substance units: false
name: ATP2B3
boundary condition: true
is: Q16720
initial amount: NaN
initial concentration: NaN

metaM Rtotal c
constant: false
notes: FORMULA: CO2FULLR CHARGE: -1
is: SBO:0000247
is: CHEBI:16189
initial amount: NaN
is: HMDB01448
initial concentration: 1.0
name: R total
type: Species
has only substance units: false
boundary condition: false

metaR r1647
product: MODEL1310110026#
is: SBO:0000185
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110026#
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110026#_866fc7ac_00b8_4326_81ad_374d1b82fc17
type: Species
name: _H17063_1_c
initial amount: NaN
is encoded by: hsa:H17063
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110026#_a89060b9_c832_4a6b_a08a_2fe49e43f572
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:64834
is: Q9BW60
name: ELOVL1
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_ff66c440_2db1_430a_9094_772812486af3
initial concentration: NaN
is encoded by: hsa:5281
is: Q6IB04
has only substance units: false
type: Species
boundary condition: true
constant: false
name: PIGF
is: SBO:0000252
initial amount: NaN

metaM hco3 m
has only substance units: false
is: HMDB00595
is: SBO:0000247
name: Bicarbonate
is: CHEBI:17544
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: C00288
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288

metaM arachdcoa m
constant: false
name: arachidonoyl-CoA(4-)
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:57368
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB06523
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249

metaR RE1691M
notes: GENE_ASSOCIATION: (7263.1) SUBSYSTEM: Miscellaneous EC Number: 2.8.1.1 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:9070219 NOTES:
reactant: MODEL1310110026#
fast: false
is version of: http://identifiers.org/ec-code/2.8.1.1
product: MODEL1310110026#
is: SBO:0000176
kinetic law: MODEL1310110026#
is described by: ECO:0000000
modifier: MODEL1310110026#
reversible: true
type: Reaction
name: RE1691

metaR r0267
type: Reaction
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
modifier: MODEL1310110026#
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
fast: false
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.5.1.9
is: SBO:0000176
kinetic law: MODEL1310110026#
is described by: ECO:0000000
product: MODEL1310110026#
reversible: true

metaR EX lcts LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Lactose exchange
type: Reaction

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

metaR EX ak2lgchol hs LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-lysoglycerol 3-phosphocholine exchange
type: Reaction

metaR r1646
modifier: MODEL1310110026#
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110026#
is described by: ECO:0000000
product: MODEL1310110026#

metaR ILEtec
modifier: MODEL1310110026#
product: MODEL1310110026#
reversible: true
name: L-isoleucine transport via diffusion (extracellular to cytosol)
kinetic law: MODEL1310110026#
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
is described by: ECO:0000269

metaR FAOXC226205m
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110026#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation of long chain fatty acid
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:_1 round of beta-oxidation, loses degree of desat, so no fad peroxisomal (very long chain FA) c22:6,n-3 -> c20:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#

metaR r0268
product: MODEL1310110026#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
fast: false
reversible: true
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.1.3.2
type: Reaction
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.1.3.1

metaR r1645
product: MODEL1310110026#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
reactant: MODEL1310110026#

metaM fru e
is: HMDB00660
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
type: Species
initial concentration: 1.0
name: D-Fructose
has only substance units: false
initial amount: NaN
is: C00095
is: CHEBI:15824
constant: false
boundary condition: false

metaM pro L e
is: HMDB00162
is: SBO:0000247
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
boundary condition: false
name: L-proline
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:17203
constant: false
initial concentration: 1.0

metaR RE1531M
type: Reaction
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
name: RE1531
fast: false
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/4.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110026#_8aa999a9_62a7_4f92_9b17_9244a91a28d2
is: SBO:0000252
boundary condition: true
is encoded by: hsa:10229
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is: Q99807
name: COQ7
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_c74aaf59_ba61_4063_ab7e_886406488f46
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: B4DK61
constant: false
is encoded by: hsa:51
has only substance units: false
name: ACOX1
boundary condition: true
type: Species

metaM no c
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
name: Nitric oxide
boundary condition: false
is: CHEBI:16480
is: C00533
is: HMDB03378
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_4644bc25_a0f8_4c81_9b31_84a2e75cc577
initial amount: NaN
constant: false
is: Q96QE2
is encoded by: hsa:114134
name: SLC2A13
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110026#_619b9647_df6e_4793_8c33_9c2f0f793b7b
constant: false
name: _AI469183_1_x
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AI469183
has only substance units: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_ea8ef8e9_53ea_4347_a909_a57acc8e3cfa
is: SBO:0000297
constant: false
initial amount: NaN
has part: Q9HCC0
has part: Q96RQ3
has only substance units: false
initial concentration: NaN
type: Species
name: MCCC1:MCCC2
is encoded by: hsa:64087
is encoded by: hsa:56922
boundary condition: true

metaM glcur r
is: HMDB00127
is: CHEBI:15748
initial amount: NaN
constant: false
name: D-glucuronate
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_594d5e9c_8368_4eb1_aeb2_5b7e6ab2a82e
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:480
type: Species
is: Q13733
is: SBO:0000252
initial amount: NaN
name: ATP1A4

metaR ACSm
kinetic law: MODEL1310110026#
name: acetyl-CoA synthetase
fast: false
product: MODEL1310110026#
reactant: MODEL1310110026#
type: Reaction
is described by: ECO:0000304
is: SBO:0000176
reversible: false
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (84532.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 6.2.1.1 Confidence Level: 2 AUTHORS: PMID:11150295,PMID:4326157 NOTES:IF
is version of: http://identifiers.org/ec-code/6.2.1.1

metaR FAEL183
name: fatty-acyl-CoA elongation (n-C18:3CoA)
reversible: false
product: MODEL1310110026#
is described by: ECO:0000000
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
is: SBO:0000176
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ

http://identifiers.org/biomodels.db/MODEL1310110026#_78e41789_c1ec_437c_bd6d_4e66245a65df
is: Q6P4B4
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: PFAS
initial amount: NaN
is encoded by: hsa:5198
constant: false
has only substance units: false

metaR RE2973N
reversible: true
kinetic law: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.154
modifier: MODEL1310110026#
is: SBO:0000176
type: Reaction
name: RE2973
reactant: MODEL1310110026#
is described by: ECO:0000000
product: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_dfbe494c_21cb_45bf_a276_5a458173cef2
is: Q9UKM7
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:11253
name: MAN1B1
constant: false
is: SBO:0000252
initial concentration: NaN

metaR r1644
is described by: ECO:0000000
kinetic law: MODEL1310110026#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
modifier: MODEL1310110026#
reactant: MODEL1310110026#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110026#
type: Reaction

metaM ppp9 m
name: Protoporphyrin
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:36159
constant: false
initial amount: NaN
notes: FORMULA: C34H32N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00905 EHMN_ABBREVIATION: C02191
type: Species
has only substance units: false
is: HMDB00241
boundary condition: false

metaR L LACt4r
is described by: ECO:0000000
reactant: MODEL1310110026#
product: MODEL1310110026#
kinetic law: MODEL1310110026#
fast: false
name: L-lactate reversible transport via sodium symport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
is: SBO:0000185
reversible: true
type: Reaction

metaR GAO1g
reactant: MODEL1310110026#
name: Ganglioside O-acetylation
type: Reaction
fast: false
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110026#
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:for humans - seq predicted SLC transporters have been found to have O-acetylation activity on gangliosides NJ
is described by: ECO:0000269
modifier: MODEL1310110026#

metaR XYLt
is: SBO:0000185
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
name: D-xylose reversible transport
is described by: ECO:0000269
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
product: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_5e87b91e_a7b5_49bf_98ae_39cc5d7d42fa
is: SBO:0000252
is encoded by: hsa:6536
initial amount: NaN
is: P48067
initial concentration: NaN
type: Species
has only substance units: false
name: SLC6A9
constant: false
boundary condition: true

metaM fru c
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
name: D-Fructose
constant: false
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00660
is: C00095
is: CHEBI:15824

metaM cyan m
is: SBO:0000247
type: Species
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
is: CHEBI:18407
constant: false
name: hydrogen cyanide
has only substance units: false
is: HMDB02084
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaR EX ttdca LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecanoate (n-C14:0)
type: Reaction

metaR RE3624M
fast: false
reactant: MODEL1310110026#
type: Reaction
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
product: MODEL1310110026#
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
name: RE3624
is version of: http://identifiers.org/ec-code/1.3.3.6

metaM so3 m
name: hydrogensulfite
is: HMDB00240
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17137
boundary condition: false
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
constant: false

metaR CHSTEROLtrc
name: transport of cholesterol into the cytosol
type: Reaction
is: SBO:0000185
product: MODEL1310110026#
kinetic law: MODEL1310110026#
is described by: ECO:0000134
fast: false
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
reversible: true

metaM pro L c
constant: false
is: HMDB00162
is: SBO:0000247
boundary condition: false
has only substance units: false
name: L-proline
type: Species
initial concentration: 1.0
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: CHEBI:17203
initial amount: NaN

metaM thcholstoic m
initial amount: NaN
constant: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
is: CHEBI:18402
is: HMDB03873
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
initial concentration: 1.0
type: Species

metaR AG13T10g
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
modifier: MODEL1310110026#
is: SBO:0000176
fast: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10331.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
product: MODEL1310110026#
type: Reaction
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#

metaM amet c
is: HMDB01185
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
initial concentration: 1.0
is: CHEBI:15414
has only substance units: false
is: SBO:0000247
name: S-Adenosyl-L-methionine
constant: false
type: Species
is: C00019
initial amount: NaN
boundary condition: false

metaR r1643
product: MODEL1310110026#
reversible: true
reactant: MODEL1310110026#
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR FAOXC4C4DCc
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: succ-->C4DCc
type: Reaction

metaR CYTK12n
reversible: true
product: MODEL1310110026#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP,dCTP),nuclear
fast: false
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110026#_b97f9a5e_71b3_4e7e_9e72_6edbbd9059e1
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2348
constant: false
boundary condition: true
name: FOLR1
type: Species
initial amount: NaN
initial concentration: NaN

metaM HC00342 c
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:16383
boundary condition: false
initial amount: NaN
name: cis-aconitate(3-)

metaR BHBt
product: MODEL1310110026#
is described by: ECO:0000000
name: (R)-3-Hydroxybutanoate transport via H+ symport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
is: SBO:0000185
type: Reaction
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
fast: false

metaM cs e deg6 l
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB01354
is: CHEBI:57455
boundary condition: false
notes: FORMULA: C31H48NO32S2 CHARGE: -3
is: SBO:0000247
type: Species
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 6

metaR DHCR72r
kinetic law: MODEL1310110026#
type: Reaction
reactant: MODEL1310110026#
is described by: ECO:0000269
name: 7-dehydrocholesterol reductase
is: SBO:0000176
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.3.1.21
modifier: MODEL1310110026#
fast: false
reversible: false

metaM C05957 r
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
boundary condition: false
is: CHEBI:27485
type: Species
is: HMDB02710
initial concentration: 1.0
name: Prostaglandin J2

metaM HC02179 e
initial amount: NaN
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: 20-hydroxy-arachidonate
type: Species
is: CHEBI:34306
constant: false

metaM glcur e
name: D-glucuronate
constant: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
initial amount: NaN
is: CHEBI:15748
initial concentration: 1.0
type: Species
is: HMDB00127
boundary condition: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_746fb8a0_f78d_4829_b5ab_83371bff527d
type: Species
name: MOGS
has only substance units: false
initial concentration: NaN
is encoded by: hsa:7841
is: F5H6D0
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true

metaM nrvnccoa x
has only substance units: false
is: SBO:0000247
name: nervonyl coenzyme A
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
is: C16532
notes: FORMULA: C45H76N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H80N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h11-12,32-34,38-40,44,55-56H,4-10,13-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b12-11-/t34-,38-,39-,40?,44-/m1/s1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_eebdf2f2_9a5c_412a_9212_4beb3b9672e1
initial amount: NaN
boundary condition: true
type: Species
constant: false
has only substance units: false
is encoded by: hsa:144195
name: SLC2A14
is: SBO:0000252
initial concentration: NaN
is: Q8TDB8

http://identifiers.org/biomodels.db/MODEL1310110026#_a260cbdf_3af9_4a1a_861d_e070edb527ba
boundary condition: true
is encoded by: hsa:6550
is: SBO:0000252
is: P48764
name: SLC9A3
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false

metaR GGH 6DHFl
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: false
modifier: MODEL1310110026#
fast: false
is version of: http://identifiers.org/ec-code/3.4.19.9
is: SBO:0000176
product: MODEL1310110026#
type: Reaction
name: Gamma-glutamyl hydrolase (6DHF), lysosomal

metaM glc D g
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:4167
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
constant: false
is: HMDB00122
name: D-glucose
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110026#_14cd6e07_4d07_4f5d_a34f_e9bee343a9f8
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
name: PLCH1
constant: false
is: Q4KWH8
is encoded by: hsa:23007
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_20c004a0_30d6_4937_b05c_c0e53ecd8910
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:AI373818
name: _AI373818_1_m
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaM ca2 c
has only substance units: false
type: Species
is: HMDB00464
initial amount: NaN
is: CHEBI:29108
is: SBO:0000247
name: calcium(2+)
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
boundary condition: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_a46e1b6a_1f1f_4f91_8296_0e5bdf53af09
initial concentration: NaN
name: ADH1A
constant: false
initial amount: NaN
is: P07327
boundary condition: true
is encoded by: hsa:124
is: SBO:0000252
has only substance units: false
type: Species

metaR EX q10 LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinone
type: Reaction

metaM ps hs c
constant: false
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
name: ps_hs[c]
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
is: CHEBI:18303
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110026#_480ec159_d39b_45ef_8f1d_a6abbca97666
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: Q9UBX3
boundary condition: true
initial amount: NaN
name: SLC25A10
is encoded by: hsa:1468

metaM thbpt c
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
type: Species
boundary condition: false
is: CHEBI:15372
constant: false
is: SBO:0000247
initial amount: NaN
name: 5,6,7,8-tetrahydrobiopterin
is: HMDB00027

metaM fad c
initial amount: NaN
is: HMDB01248
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: SBO:0000247
initial concentration: 1.0
name: Flavin adenine dinucleotide oxidized
is: CHEBI:16238
type: Species
is: C00016
has only substance units: false
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110026#_91ca38b4_5f5f_462f_b073_dc82bc892512
is encoded by: hsa:1962
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is: Q9NY65
type: Species
initial amount: NaN
is: SBO:0000252
name: EHHADH

metaM ksi pre12 g
notes: FORMULA: C135H218N9O106S3X CHARGE: -4
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 12
constant: false
is: C00130
initial amount: NaN
has only substance units: false
is: CHEBI:58053
is: HMDB00175
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_ad125b1d_757e_4368_b80f_90d55ea56559
type: Species
initial amount: NaN
name: SLC38A3
is encoded by: hsa:10991
is: SBO:0000252
has only substance units: false
boundary condition: true
is: Q99624
initial concentration: NaN
constant: false

metaR r2399
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
product: MODEL1310110026#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110026#
is described by: ECO:0000000
reactant: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false

metaR KSII CORE2t
type: Reaction
product: MODEL1310110026#
reversible: false
name: keratan sulfate II (core2) transport, golgi to extracellular
is described by: ECO:0000000
reactant: MODEL1310110026#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110026#
fast: false

metaM uri c
is: C00299
is: SBO:0000247
name: Uridine
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
initial concentration: 1.0
is: HMDB00296
is: CHEBI:16704
boundary condition: false
type: Species

metaM ha e
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
is: CHEBI:16336
type: Species
name: hyaluronan
is: SBO:0000247

metaR LPS2e
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.1.1.3
modifier: MODEL1310110026#
is described by: ECO:0000000
type: Reaction
reversible: false
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.3 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:carbonyl and extra H accounted for in R group NJ
is: SBO:0000176
name: lipase, extracellular
fast: false

metaM 1pipdn2c x
type: Species
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092
is: CHEBI:16187
has only substance units: false
name: 1-piperideine-2-carboxylate
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB01084
is: SBO:0000247
initial amount: NaN

metaR B MANNASEly
is version of: http://identifiers.org/ec-code/3.2.1.25
is: SBO:0000176
product: MODEL1310110026#
name: beta-mannosidase, lysosomal
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (4126.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.25 Confidence Level: 0 AUTHORS: PMID:9384606 NOTES:NCD
is described by: ECO:0000000
fast: false
reversible: false
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_d81ecb49_7067_4a19_a643_6db2cb9b0a16
is: Q9NRZ5
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
name: AGPAT4
is encoded by: hsa:56895

metaM glcur c
is: HMDB00127
is: SBO:0000247
name: D-glucuronate
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
constant: false
is: CHEBI:15748
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_85f7f81d_3e4b_4faa_aa77_93dd6c8542a9
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
name: ALDOA
is encoded by: hsa:226
type: Species
initial concentration: NaN

metaM HC02179 c
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: 20-hydroxy-arachidonate
is: SBO:0000247
type: Species
is: CHEBI:34306
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_d9bb047c_950b_4315_be3f_9f8a0d148412
is: F8VQS7
is encoded by: hsa:55967
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
constant: false
initial amount: NaN
name: NDUFA12
is: SBO:0000252

metaR r0055
kinetic law: MODEL1310110026#
reversible: true
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.4.2.8
notes: GENE_ASSOCIATION: (353.1) or (3251.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 0 AUTHORS: PMID:20958,PMID:4383524,PMID:4391087,PMID:6014,PMID:7107625,PMID:7107626,PMID:7144586,PMID:7763257,PMID:7993370 NOTES:IT added 2 protons (are there really 2 protons produced?)
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.2.7
type: Reaction
modifier: MODEL1310110026#
name: 2-Oxopropanal:NADP+ oxidoreductase Pyruvate metabolism EC:1.2.1.49
fast: false
product: MODEL1310110026#

metaR SERPT
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110026#
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.3.1.50
type: Reaction
notes: GENE_ASSOCIATION: (10558.1 and 9517.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.3.1.50 Confidence Level: 4 AUTHORS: NOTES:NCD
reversible: false
name: serine C-palmitoyltransferase
is: SBO:0000176

metaR EX leugly LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylglycine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_77085117_a2bf_480f_81d2_e2130cc7ef07
is: P27144
constant: false
is encoded by: hsa:205
name: AK4
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species

metaM glc D e
type: Species
boundary condition: false
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: HMDB00122
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:4167
name: D-glucose
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110026#_6b6d1c71_6032_4a0c_9253_1b1d323e34bc
has only substance units: false
boundary condition: true
is encoded by: hsa:79966
constant: false
is: SBO:0000252
name: SCD5
initial concentration: NaN
is: Q86SK9
type: Species
initial amount: NaN

metaM itp n
boundary condition: false
is: CHEBI:57614
has only substance units: false
name: ITP(3-)
is: HMDB00189
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
type: Species
is: SBO:0000247

metaM 3hexdcoa m
has only substance units: false
boundary condition: false
name: 3-hydroxyhexadecanoylcoa
initial concentration: 1.0
is: SBO:0000247
is: HMDB03932
constant: false
initial amount: NaN
is: C05258
type: Species
notes: FORMULA: C37H62N7O18P3S CHARGE: -4

metaR LEUKTRF4t
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
name: leukotriene F4 transport
is described by: ECO:0000000
product: MODEL1310110026#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR PTDCAt
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
is: SBO:0000185
reactant: MODEL1310110026#
product: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
reversible: true
is described by: ECO:0000000
name: fatty acid transport via diffusion

metaM HC01118 r
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: presqualene diphosphate(3-)
constant: false
type: Species
boundary condition: false
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
is: CHEBI:57310

metaM ps hs e
type: Species
has only substance units: false
boundary condition: false
name: phosphatidylserine
initial concentration: 1.0
is: CHEBI:18303
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
constant: false

metaM cs e deg3 l
has only substance units: false
notes: FORMULA: C37H53NO44S4 CHARGE: -6
boundary condition: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 3
constant: false
type: Species
initial amount: NaN
is: CHEBI:15748
is: HMDB00127
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110026#_42a8bcac_97ec_46fb_9d01_7770bd79acca
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:5331
is: G5E960
name: PLCB3
has only substance units: false
type: Species

metaR EX s2l2n2m2masn LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: de-Fuc form of PA6 exchange
type: Reaction

metaM fad e
initial amount: NaN
name: Flavin adenine dinucleotide oxidized
is: SBO:0000247
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
initial concentration: 1.0
is: CHEBI:16238
boundary condition: false
constant: false
is: HMDB01248
type: Species
has only substance units: false
is: C00016

metaM paps c
is: SBO:0000247
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
type: Species
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
is: HMDB01134
initial concentration: 1.0
is: CHEBI:58339
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate

http://identifiers.org/biomodels.db/MODEL1310110026#_52d8f5f3_d46d_41f6_9b45_d8b723d53bec
name: GALNT9
is: Q9HCQ5
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:50614

metaM amet m
initial concentration: 1.0
constant: false
is: HMDB01185
boundary condition: false
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: C00019
initial amount: NaN
name: S-Adenosyl-L-methionine
type: Species
is: CHEBI:15414
has only substance units: false
is: SBO:0000247

metaM uri e
has only substance units: false
is: C00299
initial amount: NaN
is: HMDB00296
type: Species
is: CHEBI:16704
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: Uridine

metaR S23T4g
modifier: MODEL1310110026#
reversible: false
reactant: MODEL1310110026#
name: beta-galactoside alpha-2,3-sialyltransferase
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.99.4
kinetic law: MODEL1310110026#
is described by: ECO:0000000
product: MODEL1310110026#
type: Reaction

metaM dctp c
initial amount: NaN
boundary condition: false
constant: false
is: HMDB00998
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
initial concentration: 1.0
has only substance units: false
is: C00458
is: SBO:0000247
is: CHEBI:16311
name: dCTP
type: Species

metaM CE5788 e
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:27485
has only substance units: false
is: HMDB02710
initial amount: NaN
is: SBO:0000247
name: kinetensin 1-7
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_f2a7c9dc_0c03_4b95_a00f_9e0902ad5361
constant: false
boundary condition: true
is: B2RA41
has only substance units: false
is encoded by: hsa:6554
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
name: SLC10A1

http://identifiers.org/biomodels.db/MODEL1310110026#_4b07edb5_b560_481b_bf4e_54ecad2f3781
is encoded by: hsa:3283
name: HSD3B1
type: Species
is: SBO:0000252
is: P14060
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_7d93568e_07b7_40e4_8e26_0e9bf86e0408
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:171425
type: Species
name: CLYBL

http://identifiers.org/biomodels.db/MODEL1310110026#_7114e246_547b_4350_9a6d_c98183e9e92a
is: SBO:0000252
type: Species
boundary condition: true
is: Q9UF12
name: PRODH2
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:58510
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_7c90ccfb_a420_43ac_a126_d25bcb0f3485
is encoded by: hsa:113026
initial amount: NaN
is: Q8N3E9
type: Species
constant: false
is: SBO:0000252
name: PLCD3
boundary condition: true
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_d1fff9da_9314_41f0_8677_019ff03c0e1b
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is: Q6FIH7
name: ATP5G1
is encoded by: hsa:516
type: Species
initial concentration: NaN

metaR r1863
is described by: ECO:0000000
product: MODEL1310110026#
fast: false
kinetic law: MODEL1310110026#
reversible: false
is: SBO:0000185
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110026#
reactant: MODEL1310110026#

metaM oaa c
initial concentration: 1.0
is: HMDB00223
is: C00036
is: CHEBI:3338
has only substance units: false
name: Oxaloacetate
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C4H2O5 CHARGE: -2
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110026#_d6ed1d95_f0c9_4642_b053_4c94d178f7f0
is: SBO:0000252
name: ATP5G1
has only substance units: false
type: Species
is: P05496
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:516

metaR 7DHFtl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:carrier-mediated transport - but which and how is unknown IT
reversible: false
reactant: MODEL1310110026#
is: SBO:0000185
kinetic law: MODEL1310110026#
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110026#
name: 7-glutamyl-DHF transport, lysosomal

metaM m5mpdol U r
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C1545H2540N20O470P20 CHARGE: -20
initial concentration: 1.0
constant: false
is: CHEBI:37634
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
type: Species
has only substance units: false
boundary condition: false

metaR INSTt4 2
product: MODEL1310110026#
type: Reaction
reactant: MODEL1310110026#
name: inositol transport via sodium symport
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000006
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD

metaR METtec
name: L-methionine transport via diffusion (extracellular to cytosol)
kinetic law: MODEL1310110026#
fast: false
modifier: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
reversible: true
is: SBO:0000185
is described by: ECO:0000269
type: Reaction

metaM prostgf2 c
constant: false
is: SBO:0000247
type: Species
is: HMDB01139
boundary condition: false
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
initial concentration: 1.0
is: CHEBI:57404
initial amount: NaN
name: prostaglandin F2alpha(1-)

http://identifiers.org/biomodels.db/MODEL1310110026#_4535f937_7250_4209_ba81_cb1bf4a1452d
name: AMY1A
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:276
initial concentration: NaN
type: Species
is: Q6NSB3

metaM drib c
name: 2-deoxy-D-ribose
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
is: CHEBI:28816
constant: false
initial concentration: 1.0
is: HMDB03224
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

metaM hco3 e
is: SBO:0000247
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: CHEBI:17544
boundary condition: false
has only substance units: false
name: Bicarbonate
is: HMDB00595
is: C00288
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0

metaR 7DHFtm
product: MODEL1310110026#
is described by: ECO:0000000
type: Reaction
reversible: false
reactant: MODEL1310110026#
is: SBO:0000185
name: 7-glutamyl-DHF transport,m mitochondrial
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:unknown mechanism. IT
fast: false

http://identifiers.org/biomodels.db/MODEL1310110026#_f6ef532b_581b_4eaa_b6e7_9a8c1df4e0cb
type: Species
boundary condition: true
constant: false
is: SBO:0000252
is: O76082
is encoded by: hsa:6584
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: SLC22A5

metaR EX phe L LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-phenylalanine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_5ce9ce52_2ea0_4e95_afa4_5700d43a2f12
is encoded by: hsa:8395
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
name: PIP5K1B
type: Species
is: O14986

metaM bhb m
has only substance units: false
constant: false
initial amount: NaN
is: HMDB00011
boundary condition: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
name: (R)-3-hydroxybutyrate
type: Species
is: CHEBI:10983
initial concentration: 1.0
is: SBO:0000247

metaR FTCD
reactant: MODEL1310110026#
product: MODEL1310110026#
reversible: false
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Folate metabolism EC Number: 4.3.1.4 Confidence Level: 4 AUTHORS: PMID:14697341 NOTES:IT
name: formimidoyltransferase cyclodeaminase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.2.5
modifier: MODEL1310110026#
is described by: ECO:0000134
kinetic law: MODEL1310110026#
fast: false
type: Reaction

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

metaR DMHPTCRNt
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 1 AUTHORS: NOTES:dmhptcoa is 'special' because its biochemical fat isn't known NJ
fast: false
kinetic law: MODEL1310110026#
reversible: true
reactant: MODEL1310110026#
is: SBO:0000185
name: 2,6 dimethylheptanoyl crn transport
type: Reaction
is described by: ECO:0000000
product: MODEL1310110026#

metaR PEt
fast: false
name: phosphatidylethanolamine transport
product: MODEL1310110026#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:
is: SBO:0000185

metaR S6TASE25ly
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
name: galactose-6-sulfate sulfatase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false
modifier: MODEL1310110026#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110026#
reversible: true
product: MODEL1310110026#
kinetic law: MODEL1310110026#

metaR RE2626M
product: MODEL1310110026#
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.14.13.15
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
name: RE2626
type: Reaction
fast: false
is: SBO:0000176
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: true
is described by: ECO:0000000

metaR MTHFD
is version of: http://identifiers.org/ec-code/1.5.1.5
modifier: MODEL1310110026#
reversible: true
is described by: ECO:0000134
kinetic law: MODEL1310110026#
product: MODEL1310110026#
name: methylenetetrahydrofolate dehydrogenase (NADP)
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (4522.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
reactant: MODEL1310110026#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_e5a2d909_a9bf_4075_8ec9_b42ef0b50909
constant: false
type: Species
is: SBO:0000252
is: O75489
name: NDUFS3
is encoded by: hsa:4722
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaM HC01415 m
boundary condition: false
is: CHEBI:27537
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276
type: Species
initial amount: NaN
constant: false
name: (2E)-Octenoyl-CoA
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaR r1861
product: MODEL1310110026#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110026#
reversible: false
reactant: MODEL1310110026#
modifier: MODEL1310110026#
type: Reaction
name: Y+LAT2 Utilized transport
fast: false

metaM pristanal x
is: CHEBI:49189
name: pristanal
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C19H38O CHARGE: 0 INCHI: InChI=1S/C19H38O/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20/h15-19H,6-14H2,1-5H3
is: HMDB01958
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR r0488
product: MODEL1310110026#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:
reactant: MODEL1310110026#
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110026#
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34
is: SBO:0000176

metaM hco3 c
type: Species
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: CHEBI:17544
constant: false
initial concentration: 1.0
name: Bicarbonate
has only substance units: false
is: C00288
is: SBO:0000247
is: HMDB00595
initial amount: NaN
boundary condition: false

metaR KCC2t
is: SBO:0000185
product: MODEL1310110026#
fast: false
type: Reaction
reversible: true
name: K+-Cl- cotransporter (NH4+)
modifier: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
kinetic law: MODEL1310110026#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110026#_5d7c4bee_7356_4a37_883f_85e7ba4644df
constant: false
initial concentration: NaN
is: SBO:0000252
is: Q86YT5
boundary condition: true
initial amount: NaN
name: SLC13A5
is encoded by: hsa:284111
has only substance units: false
type: Species

metaM prostgf2 e
is: HMDB01139
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:57404
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
name: prostaglandin F2alpha(1-)
constant: false
is: SBO:0000247

metaR ACACT1rm
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
name: acetyl-CoA C-acetyltransferase, mitochondrial
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.9
is described by: ECO:0000000
is: SBO:0000176
fast: false
product: MODEL1310110026#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV
modifier: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_9e701eb8_c597_4498_a65d_1025aeab8a3d
boundary condition: true
constant: false
is: Q16222
name: UAP1
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6675

metaM sbcoa c
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
has only substance units: false
is: HMDB00791
is: C02838
type: Species
constant: false
initial amount: NaN
name: suberylcoa
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110026#_f2b8bb07_0dc8_43d7_b7a6_42c86ef29a84
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:2348
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
name: FOLR1

http://identifiers.org/biomodels.db/MODEL1310110026#_56c5e443_bdaf_4f15_a5c8_f16e2dae0a74
is: SBO:0000252
initial amount: NaN
name: ALDH4A1
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:8659
type: Species

metaM paps g
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
has only substance units: false
is: SBO:0000247
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
constant: false
is: CHEBI:58339
is: HMDB01134

metaR r1862
kinetic law: MODEL1310110026#
reversible: false
modifier: MODEL1310110026#
is: SBO:0000185
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
product: MODEL1310110026#

metaM ca2 e
initial amount: NaN
initial concentration: 1.0
is: HMDB00464
type: Species
constant: false
is: CHEBI:29108
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
boundary condition: false
has only substance units: false
is: SBO:0000247
name: calcium(2+)

http://identifiers.org/biomodels.db/MODEL1310110026#_62af825d_6960_40e9_bff3_69dc1a77d3b1
boundary condition: true
name: ATP5F1
initial concentration: NaN
is encoded by: hsa:515
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_5e889bb1_7478_4d5f_8c21_bbea795d278c
initial concentration: NaN
has only substance units: false
is encoded by: hsa:83715
boundary condition: true
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
is: B1AK53
name: ESPN

metaM phe L c
initial amount: NaN
constant: false
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:17295
initial concentration: 1.0
is: HMDB00159
name: L-phenylalanine

metaR RE2973C
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.7.11.1
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.137
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.7.1.154
modifier: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (5290.1) or (5291.1) or (5294.1) or (5289.1) or (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:
name: RE2973
kinetic law: MODEL1310110026#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.153
type: Reaction

metaR r0381
name: hypotaurine:NAD+ oxidoreductase Taurine and hypotaurine metabolism EC:1.8.1.3
is: SBO:0000176
fast: false
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000000
kinetic law: MODEL1310110026#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.8.1.3 Confidence Level: 0 AUTHORS: PMID:13979247,PMID:16680556,PMID:7295801 NOTES:
type: Reaction

metaM tetpent6 c
initial concentration: 1.0
name: tetracosapentaenoic acid, n-6
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
constant: false
is: HMDB06322
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-

metaR GLCNACPT U
is: SBO:0000176
fast: false
is described by: ECO:0000000
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reversible: false
type: Reaction
name: UDP-GlcNAc:dolichol-phosphate GlcNAc phosphotransferase (uterus)
is version of: http://identifiers.org/ec-code/2.7.8.15
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (1798.1) or (1798.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.7.8.15 Confidence Level: 0 AUTHORS: NOTES:NCD

metaR EX bglc LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange reaction for beta glucans
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_75095bb3_0ba7_4bf1_ae59_8a55bdc99a14
initial concentration: NaN
is: O95954
is: SBO:0000252
is encoded by: hsa:10841
type: Species
name: FTCD
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false

metaM gthox m
initial amount: NaN
boundary condition: false
is: HMDB03337
type: Species
constant: false
is: CHEBI:58297
initial concentration: 1.0
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_c12a5864_570f_4fb7_8f7e_fa65fe377b02
type: Species
name: SLC5A5
is: SBO:0000252
boundary condition: true
is: Q92911
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6528
initial amount: NaN

metaR DM anth
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

metaR GLNyLATthc
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Glutamine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

metaM ps hs m
name: ps_hs[m]
is: CHEBI:18303
type: Species
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

metaR S6T11g
is described by: ECO:0000000
reactant: MODEL1310110026#
is: SBO:0000176
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
product: MODEL1310110026#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
reversible: false
fast: false

metaR r1570
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110026#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110026#

metaR MANt4
modifier: MODEL1310110026#
fast: false
name: D-mannose transport via sodium cotransport
is: SBO:0000185
kinetic law: MODEL1310110026#
type: Reaction
reactant: MODEL1310110026#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
product: MODEL1310110026#

metaR CHOLATEt
fast: false
name: cholate transport via bicarbonate countertransport
reversible: true
is described by: ECO:0000269
product: MODEL1310110026#
modifier: MODEL1310110026#
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
type: Reaction
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
is: SBO:0000185

metaR EX arach LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for arachidate
type: Reaction

metaM ha l
initial concentration: 1.0
boundary condition: false
type: Species
name: hyaluronan
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
is: CHEBI:16336
constant: false
has only substance units: false

metaR TPI
type: Reaction
modifier: MODEL1310110026#
fast: false
reversible: true
kinetic law: MODEL1310110026#
product: MODEL1310110026#
name: triose-phosphate isomerase
is version of: http://identifiers.org/ec-code/5.3.1.1
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
is: SBO:0000176
is described by: ECO:0000134
reactant: MODEL1310110026#

metaR r0594
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
kinetic law: MODEL1310110026#
product: MODEL1310110026#
modifier: MODEL1310110026#
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
fast: false
reactant: MODEL1310110026#
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000176

metaR MTHFC
is version of: http://identifiers.org/ec-code/1.5.1.5
name: methenyltetrahydrofolate cyclohydrolase
is described by: ECO:0000134
reactant: MODEL1310110026#
product: MODEL1310110026#
type: Reaction
notes: GENE_ASSOCIATION: (4522.1) or (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
kinetic law: MODEL1310110026#
reversible: true
fast: false
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.5.4.9
is: SBO:0000176

metaM hexc c
boundary condition: false
notes: FORMULA: C26H51O2 CHARGE: -1 INCHI: InChI=1S/C26H52O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26(27)28/h2-25H2,1H3,(H,27,28)/p-1
initial amount: NaN
type: Species
has only substance units: false
is: HMDB02356
name: cerotate
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:31013

metaR M4BTAer
type: Reaction
is described by: ECO:0000000
fast: false
name: M4B transamidase, endoplasmic reticulum
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (10026.1) and (128869.1) and (8733.1) and (94005.1) and (51604.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10727241,PMID:11483512,PMID:12802054,PMID:15208306,PMID:9356492,PMID:9468317 NOTES:EC 2.6.-.- NCD
is: SBO:0000176
reversible: false
product: MODEL1310110026#
modifier: MODEL1310110026#
reactant: MODEL1310110026#

metaM hexdicoa r
boundary condition: false
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
initial amount: NaN
initial concentration: 1.0
is: HMDB00672
is: C08260
has only substance units: false
name: hexadecanedioylcoa

metaM itp c
is: CHEBI:57614
is: HMDB00189
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
name: ITP(3-)
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
is: SBO:0000247
initial amount: NaN

metaR r1571
fast: false
product: MODEL1310110026#
type: Reaction
reversible: true
reactant: MODEL1310110026#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110026#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM coucoa m
name: 4-coumaroyl-CoA(4-)
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C30H38N7O18P3S1 CHARGE: -4 INCHI: InChI=1S/C30H42N7O18P3S/c1-30(2,25(42)28(43)33-10-9-20(39)32-11-12-59-21(40)8-5-17-3-6-18(38)7-4-17)14-52-58(49,50)55-57(47,48)51-13-19-24(54-56(44,45)46)23(41)29(53-19)37-16-36-22-26(31)34-15-35-27(22)37/h3-8,15-16,19,23-25,29,38,41-42H,9-14H2,1-2H3,(H,32,39)(H,33,43)(H,47,48)(H,49,50)(H2,31,34,35)(H2,44,45,46)/p-4/t19-,23-,24-,25+,29-/m1/s1
is: C00223
is: CHEBI:57355
has only substance units: false
type: Species

metaM 3hexdcoa c
initial amount: NaN
is: SBO:0000247
constant: false
name: 3-hydroxyhexadecanoylcoa
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C37H62N7O18P3S CHARGE: -4
is: C05258
is: HMDB03932
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110026#_44dd196b_0a19_4cdd_9c81_47cf09adbfd0
is encoded by: hsa:AI222095
name: _AI222095_1_m
boundary condition: true
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaM phyt c
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
is: HMDB00801
is: CHEBI:37257
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
name: phytanate
is: SBO:0000247

metaR PAIL45P HStn
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
fast: false
kinetic law: MODEL1310110026#
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:

metaM tetpent6 e
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: tetracosapentaenoic acid, n-6
boundary condition: false
constant: false
type: Species
is: HMDB06322
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-
has only substance units: false

metaM acnam c
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:35418
name: N-acetylneuraminate
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
is: SBO:0000247
is: HMDB00230

http://identifiers.org/biomodels.db/MODEL1310110026#_2505feb6_5b68_4c32_8db8_f70eff2224a2
is: O76062
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:7108
initial amount: NaN
has only substance units: false
name: TM7SF2
type: Species
initial concentration: NaN

metaR r2032
kinetic law: MODEL1310110026#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
reactant: MODEL1310110026#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110026#
modifier: MODEL1310110026#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR ALAt2r
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
product: MODEL1310110026#
reversible: true
is: SBO:0000185
modifier: MODEL1310110026#
is described by: ECO:0000304
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
type: Reaction
fast: false
name: L-alanine reversible transport via proton symport

metaR LGNCt
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110026#
name: fatty acid transport via diffusion
reactant: MODEL1310110026#
product: MODEL1310110026#
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

metaR ST8SIA11
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.99.8
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
reversible: false
type: Reaction
name: Beta-galactoside alpha-2,3-sialyltransferase
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
fast: false
product: MODEL1310110026#
is: SBO:0000176

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

metaR RPEc
product: MODEL1310110026#
reactant: MODEL1310110026#
is: SBO:0000176
kinetic law: MODEL1310110026#
is described by: ECO:0000134
reversible: true
type: Reaction
name: ribulose 5-phosphate 3-epimerase
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2

http://identifiers.org/biomodels.db/MODEL1310110026#_be28a4bf_c91b_4bf1_8b68_e748a1fe7b1b
is: Q10471
initial amount: NaN
name: GALNT2
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
constant: false
is encoded by: hsa:2590

metaR ODECOAtx
name: fatty acid intracellular transport
reversible: true
kinetic law: MODEL1310110026#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is: SBO:0000185
product: MODEL1310110026#
type: Reaction
reactant: MODEL1310110026#
fast: false

metaM aicar e
is: HMDB01517
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H13N4O8P CHARGE: -2
boundary condition: false
is: C04677
is: SBO:0000247
is: CHEBI:58475
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
constant: false

metaR KSItly
name: keratan sulfate I transport, extracellular to lysosome
is: SBO:0000185
fast: false
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110026#
product: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110026#_56d2c29d_94a3_4f2c_b971_bfc45c2feed2
is encoded by: hsa:763
name: CA5A
initial amount: NaN
constant: false
is: P35218
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true

metaR EX leuktrA4 LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene A4 exchange
type: Reaction

metaR r0596
reactant: MODEL1310110026#
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
product: MODEL1310110026#
kinetic law: MODEL1310110026#
fast: false
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110026#
reversible: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
is: SBO:0000176

metaM dctp n
initial amount: NaN
boundary condition: false
is: CHEBI:16311
has only substance units: false
constant: false
name: dCTP
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: HMDB00998
type: Species
is: C00458

metaM k e
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
is: SBO:0000247
initial amount: NaN
name: potassium
constant: false
boundary condition: false
has only substance units: false
is: HMDB00586
is: CHEBI:29103
is: C00238
type: Species
initial concentration: 1.0

metaR r1573
reversible: true
type: Reaction
is: SBO:0000185
product: MODEL1310110026#
is described by: ECO:0000000
kinetic law: MODEL1310110026#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110026#

metaM itp e
is: HMDB00189
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:57614
name: ITP(3-)
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
has only substance units: false

metaR sink tetdece1coa LPAREN c RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: TETDECE1COASINK
type: Reaction

metaM succ x
is: CHEBI:30031
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
boundary condition: false
name: Succinate
is: HMDB00254
constant: false
is: C00042
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false

metaM cs a deg2 l
type: Species
is: SBO:0000247
is: CHEBI:15748
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C37H55NO38S2 CHARGE: -4
boundary condition: false
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 2
is: HMDB00127

metaM rib D c
constant: false
has only substance units: false
name: D-ribose
is: HMDB00283
is: CHEBI:16988
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
type: Species

metaR GACPAILter
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14517336 NOTES:NCD
name: glucosaminyl-acylphosphatidylinositol ER flippase
reactant: MODEL1310110026#
reversible: false
fast: false
is: SBO:0000185
product: MODEL1310110026#
type: Reaction
is described by: ECO:0000000

metaR PFK
reversible: false
is described by: ECO:0000304
type: Reaction
reactant: MODEL1310110026#
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (5214.1) or (5211.2) or (5214.1 and 5211.1) or (5214.1 and 5213.1) or (5213.1) or (5214.1 and 5211.2) or (5211.1) or (5211.1 and 5213.1) or (5213.1 and 5211.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110026#
fast: false
name: phosphofructokinase
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.7.1.11
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110026#_146c8422_927c_4c64_84a8_f7b8829beafc
initial concentration: NaN
is: Q71UM8
type: Species
initial amount: NaN
is encoded by: hsa:108
name: ADCY2
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false

metaM phyt e
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:37257
is: SBO:0000247
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
has only substance units: false
name: phytanate
is: HMDB00801
type: Species
initial amount: NaN

metaR UAG4E
fast: false
product: MODEL1310110026#
reactant: MODEL1310110026#
modifier: MODEL1310110026#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/5.1.3.2
is described by: ECO:0000304
type: Reaction
name: UDP-N-acetylglucosamine 4-epimerase
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110026#_a10bdf34_ac6b_4be6_af5e_d3d1c5f4cc4d
initial concentration: NaN
type: Species
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: ADH5
has only substance units: false
is encoded by: hsa:128
is: Q6IRT1

metaM srtn c
name: serotonin(1+)
boundary condition: false
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:350546
is: SBO:0000247
is: HMDB00259

metaR r1976
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110026#
reactant: MODEL1310110026#
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
is: SBO:0000185

metaM dd2coa m
name: trans-dodec-2-enoyl-CoA(4-)
is: SBO:0000247
initial amount: NaN
is: CHEBI:57330
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB03712
boundary condition: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
constant: false

metaR SPHS1Pte
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
type: Reaction
product: MODEL1310110026#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ
reversible: true
is: SBO:0000185
name: sphingosine-1-phosphate transport
fast: false

metaM 3dpdhb m
is: CHEBI:50775
constant: false
boundary condition: false
initial amount: NaN
name: 3-Decaprenyl-4,5-dihdydroxybenzoate
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C57H85O4 CHARGE: -1 INCHI: InChI=1S/C57H86O4/c1-43(2)21-12-22-44(3)23-13-24-45(4)25-14-26-46(5)27-15-28-47(6)29-16-30-48(7)31-17-32-49(8)33-18-34-50(9)35-19-36-51(10)37-20-38-52(11)39-40-53-41-54(57(60)61)42-55(58)56(53)59/h21,23,25,27,29,31,33,35,37,39,41-42,58-59H,12-20,22,24,26,28,30,32,34,36,38,40H2,1-11H3,(H,60,61)/b44-23+,45-25+,46-27+,47-29+,48-31+,49-33+,50-35+,51-37+,52-39+
initial concentration: 1.0

metaR GASNASE3ly
is described by: ECO:0000000
kinetic law: MODEL1310110026#
reversible: false
reactant: MODEL1310110026#
name: glycosylasparaginase, lysosomal
is version of: http://identifiers.org/ec-code/3.5.1.26
modifier: MODEL1310110026#
is: SBO:0000176
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.5.1.26 Confidence Level: 4 AUTHORS: PMID:1703489,PMID:2401370,PMID:8002961 NOTES:NCD
product: MODEL1310110026#
fast: false
type: Reaction

metaR SADT
is version of: http://identifiers.org/ec-code/2.7.1.25
name: sulfate adenylyltransferase
type: Reaction
modifier: MODEL1310110026#
reactant: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
is: SBO:0000176
product: MODEL1310110026#
is described by: ECO:0000269
kinetic law: MODEL1310110026#
reversible: false

metaM c81crn e
has only substance units: false
type: Species
notes: FORMULA: C15H27NO4 CHARGE: 0
is: SBO:0000247
initial amount: NaN
is: HMDB13324
constant: false
name: octenoyl carnitine
initial concentration: 1.0
boundary condition: false

metaR r0384
type: Reaction
product: MODEL1310110026#
reactant: MODEL1310110026#
name: 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2
is: SBO:0000176
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
reversible: false
kinetic law: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_d12c59c9_5703_49ff_a01f_89d5a84b083a
constant: false
name: PTEN
boundary condition: true
type: Species
is: F6KD01
initial amount: NaN
is encoded by: hsa:5728
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR HMGCOAtm
is described by: ECO:0000000
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:NCD
name: Hydroxymethylglutaryl-CoA reversible mitochondrial transport
type: Reaction
reversible: true
product: MODEL1310110026#

metaR SUCOAS1m
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.4
name: Succinate--CoA ligase (GDP-forming)
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
type: Reaction
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
is described by: ECO:0000000
reactant: MODEL1310110026#
product: MODEL1310110026#
reversible: true
is: SBO:0000176

metaR r1977
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110026#
reversible: false
fast: false
is described by: ECO:0000000
product: MODEL1310110026#
reactant: MODEL1310110026#
name: Y+LAT2 Utilized transport
type: Reaction
kinetic law: MODEL1310110026#

metaM glc D c
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:4167
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: HMDB00122
type: Species
name: D-glucose

metaM k c
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: HMDB00586
is: C00238
initial concentration: 1.0
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
is: CHEBI:29103
name: potassium

metaR UDPACGALtl
product: MODEL1310110026#
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110026#
is described by: ECO:0000000
name: udpacgal intracellular transport
reversible: true
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - there are UDPACGAL-translocators for ER and Golgi, however no info on lysosomal - poor support for this NJ

metaM itaccoa m
is: SBO:0000247
is: CHEBI:57381
has only substance units: false
type: Species
initial amount: NaN
is: HMDB03377
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
boundary condition: false
initial concentration: 1.0
name: itaconyl-CoA(5-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_87c4a268_87e3_4b63_bf2d_32ff16929df1
name: LHPP
initial concentration: NaN
is: Q9H008
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:64077
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_b49bf24f_0d19_4822_9ef7_5447591a4d7d
constant: false
initial concentration: NaN
has only substance units: false
type: Species
name: NDUFA3
is encoded by: hsa:4696
initial amount: NaN
is: O95167
boundary condition: true
is: SBO:0000252

metaM oaa m
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
has only substance units: false
initial amount: NaN
is: HMDB00223
boundary condition: false
type: Species
constant: false
name: Oxaloacetate
initial concentration: 1.0
is: CHEBI:16452
is: C00036
is: SBO:0000247

metaR NADtru
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
product: MODEL1310110026#
reversible: false
name: NAD transporter, endoplasmic reticulum
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#

metaR C8CRNe
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of octanoyl carnitine into the extra cellular space
type: Reaction

metaM srtn e
constant: false
boundary condition: false
name: serotonin(1+)
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
type: Species
is: CHEBI:350546
is: SBO:0000247
is: HMDB00259
has only substance units: false

metaM rib D e
boundary condition: false
initial amount: NaN
name: D-ribose
type: Species
initial concentration: 1.0
constant: false
is: HMDB00283
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
is: CHEBI:16988

http://identifiers.org/biomodels.db/MODEL1310110026#_a8b661ad_a864_4da2_b6a2_8636b1e31686
type: Species
has only substance units: false
name: SLC16A7
boundary condition: true
is encoded by: hsa:9194
initial amount: NaN
is: Q8NEM3
initial concentration: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110026#_9c717c81_df4f_4af4_be2b_1faceb28138d
is encoded by: hsa:80025
has only substance units: false
constant: false
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: Q6P1K9
name: PANK2

metaR C50CPT1
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of isovalerylcarnitine
type: Reaction

metaR GCC2bim
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.8.1.4
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.4.4.2
is: SBO:0000176
reversible: false
reactant: MODEL1310110026#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.2.10
product: MODEL1310110026#
name: glycine-cleavage system (lipoamide) irreversible, mitochondrial
modifier: MODEL1310110026#

metaR G16MT U
product: MODEL1310110026#
fast: false
kinetic law: MODEL1310110026#
name: Glycolipid 1,6-alpha-D-mannosyltransferase (uterus)
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
is described by: ECO:0000000
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110026#_8cd98f42_38c0_4ce9_b5e1_d48e6ff2814b
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
is: P14060
constant: false
is encoded by: hsa:3283
name: HSD3B1
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_2a250209_bd82_48da_bc70_ec48c75a0f30
name: HIBADH
is: P31937
constant: false
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:11112
boundary condition: true

metaM c81crn c
is: SBO:0000247
name: octenoyl carnitine
boundary condition: false
has only substance units: false
is: HMDB13324
constant: false
notes: FORMULA: C15H27NO4 CHARGE: 0
initial amount: NaN
type: Species
initial concentration: 1.0

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

metaR r1975
fast: false
name: Y+LAT2 Utilized transport
reactant: MODEL1310110026#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reversible: false
modifier: MODEL1310110026#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r0386
reversible: false
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
reactant: MODEL1310110026#
name: 4-methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
is: SBO:0000176
product: MODEL1310110026#
fast: false
is described by: ECO:0000000
type: Reaction

metaR r0051
fast: false
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.3.5
modifier: MODEL1310110026#
is: SBO:0000176
product: MODEL1310110026#
is described by: ECO:0000000
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_89d78457_99ae_4948_b31f_41f864985b97
type: Species
is: SBO:0000252
is: A8K003
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:5372
name: PMM1
has only substance units: false

metaR r2035
product: MODEL1310110026#
reactant: MODEL1310110026#
fast: false
reversible: false
type: Reaction
modifier: MODEL1310110026#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110026#

metaM HC01434 m
initial concentration: 1.0
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
name: oxalatosuccinate(3-)
is: SBO:0000247
is: CHEBI:58931
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_39223090_b9c2_4926_925e_682dc3b66fd4
boundary condition: true
is encoded by: hsa:5139
type: Species
name: PDE3A
is: Q14432
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN

metaR FAOXC161802m
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
product: MODEL1310110026#
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation fatty acid
is described by: ECO:0000269
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_3f517b74_fe11_4081_91d4_5c8ce7b37019
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110026#_a4bf6340_f4b5_4482_8fc8_e05b756a8ce6
name: EARS2
is encoded by: hsa:124454
is: Q5JPH6
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_f0d7f31e_7f29_49f2_ab69_e688f7953b6f
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
name: SLC26A1
is encoded by: hsa:10861
constant: false
has only substance units: false
is: SBO:0000252

metaR VITD3t2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is taken up from peripheral cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
type: Reaction
is: SBO:0000185
product: MODEL1310110026#
reversible: false
kinetic law: MODEL1310110026#
name: Vitamin D3 uptake
fast: false
reactant: MODEL1310110026#
is described by: ECO:0000000

metaR FAOXC12DCx
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecanedioyl carnitine
type: Reaction

metaR MMSAD3m
product: MODEL1310110026#
reactant: MODEL1310110026#
modifier: MODEL1310110026#
is described by: ECO:0000269
kinetic law: MODEL1310110026#
is: SBO:0000176
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093,PMID:6418146 NOTES:also EC 1.2.1.18 - NCD
is version of: http://identifiers.org/ec-code/1.2.1.27
name: methylmalonate-semialdehyde dehydrogenase (malonic semialdehyde), mitochondrial
fast: false

metaR CSPG Btly
is described by: ECO:0000000
reactant: MODEL1310110026#
product: MODEL1310110026#
name: chondroitin sulfate B transport, extracellular to lysosome
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110026#
type: Reaction

metaR r1557
reactant: MODEL1310110026#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000

metaR PItx
product: MODEL1310110026#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reactant: MODEL1310110026#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false
name: Phosphate transporter, peroxisome
kinetic law: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_4194f9da_4dfc_4cfb_9ea6_ee0f6bde3906
boundary condition: true
is: P21953
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
name: BCKDHB
type: Species
initial amount: NaN
is encoded by: hsa:594

metaM xol7aone c
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB01993
boundary condition: false
constant: false
name: 7alpha-hydroxycholest-4-en-3-one
is: CHEBI:17899
initial amount: NaN

metaR r1652
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110026#
product: MODEL1310110026#
reversible: true
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR PSDm hs
reversible: false
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
product: MODEL1310110026#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110026#
fast: false
name: Phosphatidylserine decarboxylase
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ
is version of: http://identifiers.org/ec-code/4.1.1.65
is: SBO:0000176

metaR r2506
type: Reaction
kinetic law: MODEL1310110026#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
product: MODEL1310110026#
name: Utilized transport
fast: false
reactant: MODEL1310110026#
is described by: ECO:0000000
is: SBO:0000185

metaR G14T11g
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
product: MODEL1310110026#
reactant: MODEL1310110026#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110026#
is: SBO:0000176
type: Reaction
reversible: false

metaM pristanal c
boundary condition: false
name: pristanal
constant: false
has only substance units: false
is: CHEBI:49189
initial amount: NaN
notes: FORMULA: C19H38O CHARGE: 0 INCHI: InChI=1S/C19H38O/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20/h15-19H,6-14H2,1-5H3
type: Species
is: HMDB01958
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110026#_91efc684_2b47_402b_aa17_d3639e418b80
initial amount: NaN
is: Q6IBE6
name: ST3GAL4
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:6484

http://identifiers.org/biomodels.db/MODEL1310110026#_2ae81577_42ee_424d_8a2c_87e150ed07db
constant: false
name: ABCB4
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
is: P21439
is encoded by: hsa:5244
initial amount: NaN

metaM cspg a e
is: C00106
is: CHEBI:17568
initial amount: NaN
has only substance units: false
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
constant: false
is: HMDB00300
boundary condition: false
is: SBO:0000247
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
initial concentration: 1.0
type: Species

metaR HPYRRy
type: Reaction
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (9380.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.79 Confidence Level: 4 AUTHORS: PMID:2689175,PMID:9038835 NOTES:JLR
name: Hydroxypyruvate reductase (NADPH)
fast: false
is: SBO:0000176
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.1.1.79

metaR r1556
product: MODEL1310110026#
kinetic law: MODEL1310110026#
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR NCKt
modifier: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
name: Na+/Ca2+-K+ exchange
kinetic law: MODEL1310110026#
fast: false
reversible: true
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110026#_d39f308b_becd_44ab_abc7_d753c2e32955
name: GUCY1A2
is: SBO:0000252
is encoded by: hsa:2977
boundary condition: true
constant: false
is: P33402
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN

metaM o2s e
has only substance units: false
name: superoxide
initial concentration: 1.0
is: HMDB02168
type: Species
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: SBO:0000247
is: CHEBI:18421
initial amount: NaN
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_58341639_10dd_4b1f_850e_fe1ba9ef53cb
constant: false
initial amount: NaN
is: P32929
is encoded by: hsa:1491
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
name: CTH
initial concentration: NaN

metaR r1651
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110026#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110026#
reversible: true
fast: false

metaM q10h2 m
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
is: HMDB13111
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
name: Ubiquinol-10
initial amount: NaN
is: http://identifiers.org/pubchem.compound/6504740
type: Species

metaM acgal l
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:28037
constant: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
is: HMDB00212
initial concentration: 1.0
has only substance units: false
name: N-acetyl-D-galactosamine

metaR r2507
is: SBO:0000185
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is described by: ECO:0000000
product: MODEL1310110026#
type: Reaction
name: Utilized transport
reversible: true
fast: false
reactant: MODEL1310110026#

metaM ksi pre15 g
is: CHEBI:58053
type: Species
is: SBO:0000247
is: C00130
is: HMDB00175
initial amount: NaN
constant: false
name: keratan sulfate I biosynthesis, precursor 15
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C149H240N10O119S4X CHARGE: -5

metaM methf m
type: Species
boundary condition: false
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
name: (6R)-5,10-methenyltetrahydrofolate
is: CHEBI:57455
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB01354

metaM ksii core2 deg5 l
constant: false
has only substance units: false
is: CHEBI:12936
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C50H82N4O38SX CHARGE: -1
is: HMDB00143
initial concentration: 1.0
type: Species
name: keratan sulfate II (core 2-linked), degradation product 5

http://identifiers.org/biomodels.db/MODEL1310110026#_a6c5bce0_b6a4_43b6_a7ff_ebe7825e82b7
is encoded by: hsa:275
has part: P23434
has only substance units: false
has part: P23378
is: SBO:0000297
is encoded by: hsa:2653
is encoded by: hsa:2731
boundary condition: true
initial concentration: NaN
name: DLD:GCSH:GLDC:AMT
initial amount: NaN
type: Species
constant: false
has part: P48728

metaR EX tcynt LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

metaR GALASE13ly
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
product: MODEL1310110026#
fast: false
reactant: MODEL1310110026#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000

metaR CLOHtex2
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
kinetic law: MODEL1310110026#
name: chloride transport via hydroxide countertransport (2:1)
product: MODEL1310110026#
is described by: ECO:0000304
type: Reaction
reversible: false
reactant: MODEL1310110026#
is: SBO:0000185
modifier: MODEL1310110026#
fast: false

metaM nad c
is: HMDB00902
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3305
is: C00003
name: Nicotinamide adenine dinucleotide
boundary condition: false
constant: false
type: Species
is: CHEBI:57540
has only substance units: false

metaR r1654
reactant: MODEL1310110026#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110026#
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110026#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_6979a3ca_c1c5_42be_9737_c15bfcb207be
has only substance units: false
is: O15254
boundary condition: true
initial amount: NaN
is encoded by: hsa:8310
initial concentration: NaN
type: Species
is: SBO:0000252
name: ACOX3
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_7f37a590_d701_4085_a656_8199014fff53
is encoded by: hsa:4728
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is: O00217
initial concentration: NaN
name: NDUFS8
is: SBO:0000252
type: Species

metaR r0388
reversible: true
type: Reaction
reactant: MODEL1310110026#
name: Pyridoxamine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.4.3.5
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110026#
kinetic law: MODEL1310110026#
fast: false

metaR RE0830C
reactant: MODEL1310110026#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
is: SBO:0000176
is described by: ECO:0000000
name: RE0830
kinetic law: MODEL1310110026#
product: MODEL1310110026#
fast: false
reversible: true

metaR r2508
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
product: MODEL1310110026#
name: Utilized transport
is described by: ECO:0000000
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110026#
type: Reaction
reactant: MODEL1310110026#
fast: false

metaR r1401
is version of: http://identifiers.org/ec-code/2.7.10.1
reactant: MODEL1310110026#
is: SBO:0000185
fast: false
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (AA177072.1) or (AA203143.1) or (56894.1) or (56895.1) or (AGPAT7.1) or (AI818585.1) or (AI971023.1) or (1956.1) or (54898.1) or (60481.1) or (79071.1) or (114799.1) or (157570.1) or (8372.1) or (LOC647190.1) or (9926.1) or (129642.1) or (MBOAT5.1) or (79143.1) or (N63787.1) or (54995.1) or (80339.1) or (9197.1) or (6901.1) or (W87865.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6361812,PMID:8132483 NOTES:
is version of: http://identifiers.org/ec-code/3.1.1.3
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.3.1.51
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.35
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.41
is described by: ECO:0000000
product: MODEL1310110026#
name: Facilitated diffusion

metaR r1554
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
product: MODEL1310110026#
fast: false
reversible: true
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaM gdpmann c
is: CHEBI:57527
constant: false
has only substance units: false
type: Species
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
boundary condition: false
name: GDP-alpha-D-mannose(2-)
initial amount: NaN
is: HMDB01163
initial concentration: 1.0
is: SBO:0000247

metaM mem2emgacpail hs r
is: SBO:0000247
constant: false
is: CHEBI:16240
boundary condition: false
name: ({[(mannosyl),(phosphoethanolaminyl)]-dimannosyl},{phosphoethanolaminyl})-mannosyl-glucosaminyl-acylphosphatidylinositol (M4B)
has only substance units: false
notes: FORMULA: C59H110N3O40P3FULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB03125

metaR r0389
fast: false
is: SBO:0000176
name: Pyridoxine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.1.3.12
is described by: ECO:0000000
reactant: MODEL1310110026#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.1.3.12 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:
product: MODEL1310110026#
kinetic law: MODEL1310110026#

metaR r1653
kinetic law: MODEL1310110026#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110026#
is: SBO:0000185
modifier: MODEL1310110026#

metaM o2s c
is: CHEBI:18421
type: Species
initial amount: NaN
is: HMDB02168
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
boundary condition: false
initial concentration: 1.0
name: superoxide
is: SBO:0000247
has only substance units: false
constant: false

metaR VALt5m
type: Reaction
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
kinetic law: MODEL1310110026#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110026#
is: SBO:0000185
reversible: true
name: Valine reversible mitochondrial transport

metaR r2509
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
fast: false
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
product: MODEL1310110026#
name: Utilized transport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110026#_0b91b28f_2cf6_4425_86dd_5836d072423a
boundary condition: true
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:4707
name: NDUFB1
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: O75438

metaR r1553
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110026#
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#

metaR XOL7AH2tm
is: SBO:0000185
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110026#
name: lipid, flip-flop intracellular transport
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
product: MODEL1310110026#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_b3e8f4e5_f288_4ecb_b558_3040b3c6b66a
is encoded by: hsa:23057
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
name: NMNAT2
type: Species
constant: false

metaR GALK
reversible: false
is: SBO:0000176
modifier: MODEL1310110026#
name: galactokinase
is version of: http://identifiers.org/ec-code/2.7.1.157
fast: false
notes: GENE_ASSOCIATION: (2584.1) or (2585.2) or (2585.1) SUBSYSTEM: Galactose metabolism EC Number: 2.7.1.6 Confidence Level: 0 AUTHORS: PMID:4371022 NOTES:INVALID ECO TERM: IFH
is version of: http://identifiers.org/ec-code/2.7.1.6
type: Reaction
reactant: MODEL1310110026#
product: MODEL1310110026#
is described by: ECO:0000000
kinetic law: MODEL1310110026#

metaM elaid e
name: elaidate
is: HMDB00573
has only substance units: false
initial amount: NaN
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9+ HEPATONET_1.0_ABBREVIATION: HC00830
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:30825
boundary condition: false

metaM gpi hs r
initial amount: NaN
notes: FORMULA: C55H106N4O38P4FULLRCO2FULLR2CO2 CHARGE: 0
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:16240
is: HMDB03125
name: {[PE-Man-],[PE-]Man},{PE-}Man-GlcN-acylPI

metaR NDP7er
kinetic law: MODEL1310110026#
is described by: ECO:0000000
product: MODEL1310110026#
type: Reaction
reversible: false
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
reactant: MODEL1310110026#
is: SBO:0000176

metaM idour l
is: CHEBI:21338
initial amount: NaN
initial concentration: 1.0
is: HMDB02704
name: L-iduronate
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
type: Species

metaM hexc e
is: HMDB02356
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C26H51O2 CHARGE: -1 INCHI: InChI=1S/C26H52O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26(27)28/h2-25H2,1H3,(H,27,28)/p-1
initial amount: NaN
has only substance units: false
is: CHEBI:31013
name: cerotate
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110026#_8984cc2a_7b69_446a_ae21_c059fdf01d5c
name: INPP5J
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:27124

metaR ALAGLNexR
is described by: ECO:0000304
product: MODEL1310110026#
name: L-alanine/glutamine reversible exchange
is: SBO:0000185
modifier: MODEL1310110026#
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110026#_af7489f6_64bd_4554_a143_779e8868c8ed
is encoded by: hsa:9415
is: O95864
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
name: FADS2
boundary condition: true

metaM gthox c
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB03337
is: CHEBI:58297
name: Oxidized glutathione
has only substance units: false
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
is: C00127

metaM so4 e
constant: false
has only substance units: false
is: CHEBI:16189
type: Species
boundary condition: false
is: HMDB01448
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
name: sulfate
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110026#_e8fedb74_f1ef_4dba_a10a_78d2a66d1bb0
boundary condition: true
initial concentration: NaN
is encoded by: hsa:3030
initial amount: NaN
is: E9KL44
type: Species
has only substance units: false
is: SBO:0000252
name: HADHA
constant: false

metaR r1552
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: true
product: MODEL1310110026#
type: Reaction
is: SBO:0000185
fast: false

metaR S6T2g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110026#
is: SBO:0000176
fast: false
type: Reaction
modifier: MODEL1310110026#
reactant: MODEL1310110026#
product: MODEL1310110026#
reversible: false
is described by: ECO:0000000

metaR G14T7g
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (8704.1) or (8703.1) or (2683.1) or (9334.1) or (8704.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reactant: MODEL1310110026#
modifier: MODEL1310110026#
reversible: false
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
fast: false
kinetic law: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_942d3cc2_8b6d_457c_9bbd_dc3da68d6104
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3631
name: INPP4A

metaR G12MT2 U
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
fast: false
name: Glycolipid 1,2-alpha-D-mannosyltransferase (uterus)
product: MODEL1310110026#
reversible: false

metaM xol25oh r
is: CHEBI:42977
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01146
has only substance units: false
name: 25-hydroxycholesterol
is: HMDB06247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_e3b121d1_7b1f_4c16_a650_4a5d14095a76
has only substance units: false
initial amount: NaN
name: ACO1
is encoded by: hsa:48
is: SBO:0000252
boundary condition: true
is: P21399
constant: false
type: Species
initial concentration: NaN

metaR EX tettet6 LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosatetraenoic acid n-6 exchange
type: Reaction

metaM dcholcoa c
initial concentration: 1.0
has only substance units: false
is: HMDB06292
initial amount: NaN
name: chenodeoxycholoyl coenzyme a
is: CHEBI:28701
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
type: Species
boundary condition: false
constant: false
is: SBO:0000247

metaM CE5160 r
boundary condition: false
is: SBO:0000247
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-26,28,32-34,38,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5160
initial concentration: 1.0
type: Species
is: CHEBI:57923
constant: false
initial amount: NaN
has only substance units: false
name: 3-oxo-cis-9-octadecenoyl-CoA

metaR RE3524R
type: Reaction
product: MODEL1310110026#
name: RE3524
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
is: SBO:0000176
reversible: true
fast: false
reactant: MODEL1310110026#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110026#_7f38de83_dd0a_4e2e_96e2_b15b6678536f
is encoded by: hsa:5464
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is: Q15181
name: PPA1
initial concentration: NaN
is: SBO:0000252
type: Species

metaR AMETtd
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true
reactant: MODEL1310110026#
fast: false
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110026#
name: diffusion of S-Adenosyl-L-methionine
product: MODEL1310110026#

metaM stcoa m
is: C00412
is: HMDB01114
constant: false
has only substance units: false
name: Stearoyl-CoA (n-C18:0CoA)
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57394
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110026#_efa43294_05ab_4af7_a1c0_5f6639059fe8
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:10558
name: SPTLC1
boundary condition: true
has only substance units: false
is: SBO:0000252
is: O15269
type: Species

metaR r1551
product: MODEL1310110026#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110026#
type: Reaction
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM so4 c
name: sulfate
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:16189
constant: false
type: Species
boundary condition: false
is: HMDB01448

http://identifiers.org/biomodels.db/MODEL1310110026#_72a9d283_a8ca_489f_82f5_57e56a255bc4
is: SBO:0000252
name: ST3GAL5
initial amount: NaN
type: Species
is encoded by: hsa:8869
initial concentration: NaN
is: Q9UNP4
boundary condition: true
constant: false
has only substance units: false

metaM ksi deg23 l
is: HMDB00143
boundary condition: false
constant: false
notes: FORMULA: C124H201N8O106S5 CHARGE: -5
has only substance units: false
is: SBO:0000247
type: Species
name: keratan sulfate I, degradation product 23
initial amount: NaN
is: CHEBI:12936
initial concentration: 1.0

metaR DOLP Uter
kinetic law: MODEL1310110026#
name: dolichol phosphate flippase (uterus)
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
is: SBO:0000176
product: MODEL1310110026#
type: Reaction
reactant: MODEL1310110026#
fast: false
is described by: ECO:0000000

metaR EICOSTETt
is described by: ECO:0000000
name: fatty acid transport via diffusion
is: SBO:0000185
type: Reaction
reactant: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: true

metaM CE5119 m
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119
constant: false
is: CHEBI:57923
type: Species
is: SBO:0000247
name: trans-3-cis-8-tetradecadienoyl-CoA
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaR r1650
is described by: ECO:0000000
type: Reaction
product: MODEL1310110026#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110026#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_3de27cdc_7381_42b7_bdfa_b01c7ed18a43
name: SDHB
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:6390
type: Species
is: P21912
boundary condition: true
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_bbbe5790_4b96_4397_a707_32d2fa589aa7
initial amount: NaN
constant: false
is encoded by: hsa:5152
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: PDE9A
type: Species
has only substance units: false

metaR RE1530C
name: RE1530
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
product: MODEL1310110026#
type: Reaction
reactant: MODEL1310110026#
is described by: ECO:0000000
kinetic law: MODEL1310110026#
reversible: true
fast: false
is: SBO:0000176

metaR RE0344C
name: RE0344
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.65
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
is version of: http://identifiers.org/ec-code/3.1.2.2
reversible: true
modifier: MODEL1310110026#
fast: false
reactant: MODEL1310110026#
type: Reaction
product: MODEL1310110026#
kinetic law: MODEL1310110026#

metaR GALASE1ly
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110026#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110026#
is described by: ECO:0000000
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
type: Reaction
modifier: MODEL1310110026#
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

metaM aicar c
constant: false
boundary condition: false
initial concentration: 1.0
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
has only substance units: false
is: HMDB01517
is: CHEBI:58475
type: Species
is: C04677
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677

metaR RBFK
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110026#
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.7.1.26
reversible: false
name: riboflavin kinase
is: SBO:0000176
type: Reaction
reactant: MODEL1310110026#

metaR S6T13g
reversible: false
notes: GENE_ASSOCIATION: (4166.1) or (10164.1) or (23563.2) or (23563.1) or (9435.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110026#
is described by: ECO:0000000
product: MODEL1310110026#
reactant: MODEL1310110026#
modifier: MODEL1310110026#
is: SBO:0000176
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_c18b1a3c_4911_4282_a13c_cc1600343abe
has only substance units: false
has part: Q5VYT2
is: SBO:0000297
is encoded by: hsa:4731
initial concentration: NaN
is encoded by: hsa:4712
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
boundary condition: true
type: Species
initial amount: NaN
constant: false

metaM dmhptcrn m
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
is: HMDB06320
name: 2,6 dimethylheptanoyl carnitine
has only substance units: false
is: SBO:0000247
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
constant: false

metaM T antigen g
is: CHEBI:22783
initial concentration: 1.0
is: SBO:0000247
name: T antigen (core 1)
has only substance units: false
boundary condition: false
notes: FORMULA: C14H24NO10X CHARGE: 0
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_243ddc22_af37_4771_acc1_25b2d61ba5a6
name: _W74642_1_c
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:W74642
constant: false

metaM b2coa m
name: crotonoyl-CoA(4-)
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
boundary condition: false
is: HMDB02009
is: CHEBI:57332
is: SBO:0000247
initial amount: NaN
type: Species
constant: false

metaM gdp c
type: Species
initial amount: NaN
name: GDP
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58189
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: HMDB01201
is: C00035
boundary condition: false
has only substance units: false

metaM sphgn c
name: sphinganine(1+)
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
is: CHEBI:57817
type: Species
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB00269
initial concentration: 1.0
boundary condition: false

metaM ksi deg41 l
has only substance units: false
is: HMDB00143
notes: FORMULA: C34H58N2O26 CHARGE: 0
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:12936
boundary condition: false
name: keratan sulfate I, degradation product 41
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_39f9a944_a92a_4b26_87f5_06c269bc4ae6
is encoded by: hsa:51
name: ACOX1
is: B4DK61
constant: false
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110026#_4d659afb_3dbb_437d_9d9c_969650de4882
boundary condition: true
initial amount: NaN
constant: false
is: Q92835
name: INPP5D
has only substance units: false
type: Species
is encoded by: hsa:3635
is: SBO:0000252
initial concentration: NaN

metaR EX crn LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-Carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_484bebfe_3238_4424_acf8_e182306a51b8
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
is: Q16836
is encoded by: hsa:3033
constant: false
initial concentration: NaN
name: HADH
has only substance units: false

metaM nad m
name: Nicotinamide adenine dinucleotide
has only substance units: false
initial concentration: 1.0
is: C00003
boundary condition: false
is: HMDB00902
is: http://identifiers.org/pubchem.compound/3305
constant: false
is: SBO:0000247
is: CHEBI:57540
initial amount: NaN
type: Species

metaR TRIODTHYt2
reversible: true
type: Reaction
reactant: MODEL1310110026#
is described by: ECO:0000269
product: MODEL1310110026#
name: T3 transport via facilitated diffusion
kinetic law: MODEL1310110026#
is: SBO:0000185
modifier: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110026#_376d5723_2043_4b51_bfaa_d21b085a1fb7
has only substance units: false
is encoded by: hsa:2352
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
name: FOLR3
is: Q05C14

http://identifiers.org/biomodels.db/MODEL1310110026#_602b239d_fb83_4c23_9af1_1078ecff1976
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110026#_1647cf80_b34a_43d3_ad2b_93f522d526ba
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:R14373
is: SBO:0000252
name: _R14373_1_x
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_c47d7575_6aa1_49de_b1be_a20008d6e98b
initial amount: NaN
is encoded by: hsa:53947
name: A4GALT
has only substance units: false
is: Q9NPC4
constant: false
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN

metaM methf c
is: CHEBI:57455
constant: false
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
is: C00445
initial amount: NaN
type: Species
is: HMDB01354
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: 5,10-Methenyltetrahydrofolate

metaR PItn
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: true
fast: false
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
product: MODEL1310110026#
name: phosphate transport, nuclear
type: Reaction
is: SBO:0000185

metaR FPGS4m
fast: false
reactant: MODEL1310110026#
product: MODEL1310110026#
is: SBO:0000176
modifier: MODEL1310110026#
reversible: false
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT
kinetic law: MODEL1310110026#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.3.2.17
name: folylpolyglutamate synthetase (DHF), mitochondrial

metaM arachcoa c
name: arachidyl coenzyme A
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB04258
is: CHEBI:15527
boundary condition: false
constant: false
is: SBO:0000247

metaM spmd c
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
type: Species
is: C00315
initial concentration: 1.0
name: Spermidine
initial amount: NaN
is: CHEBI:57834
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB01257
has only substance units: false

metaR M1316Mg
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (4124.1) or (4122.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.114 Confidence Level: 0 AUTHORS: PMID:8524845 NOTES:NCD
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.114
reactant: MODEL1310110026#
fast: false

metaR r1659
reactant: MODEL1310110026#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
is: SBO:0000185
fast: false
product: MODEL1310110026#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110026#_554b226f_1fbb_4a6f_9803_d6093521b6d6
boundary condition: true
has only substance units: false
name: DOLPP1
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: Q86YN1
is encoded by: hsa:57171

http://identifiers.org/biomodels.db/MODEL1310110026#_70c86636_d70e_42e6_aa94_2532f74dce7a
type: Species
is encoded by: hsa:5150
name: PDE7A
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_98693278_9a9f_49fe_a2a5_5d10da5cd593
has only substance units: false
initial concentration: NaN
is encoded by: hsa:128869
initial amount: NaN
is: Q9H490
is: SBO:0000252
type: Species
constant: false
name: PIGU
boundary condition: true

metaM o2s m
boundary condition: false
type: Species
is: C00704
initial concentration: 1.0
name: Superoxide anion
is: CHEBI:18421
is: HMDB02168
constant: false
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
initial amount: NaN
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110026#_07d9d07b_acb7_4399_92bd_1a27c57bb786
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
name: _U52111_1_c
type: Species
is encoded by: hsa:U52111
constant: false
initial amount: NaN

metaM m3gacpail hs r
boundary condition: false
notes: FORMULA: C49H88NO29PFULLRCO2FULLR2CO2 CHARGE: 0
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB03125
name: trimannosyl-glucosaminyl-acylphosphatidylinositol (H4)
type: Species
initial concentration: 1.0
is: CHEBI:16240

http://identifiers.org/biomodels.db/MODEL1310110026#_4b957fc0_6983_4f21_a53e_599ce9a74c30
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:219
boundary condition: true
name: ALDH1B1
has only substance units: false
is: P30837

metaM acgal c
constant: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB00212
boundary condition: false
type: Species
is: CHEBI:28037
name: N-acetyl-D-galactosamine
initial concentration: 1.0

metaM leuktrD4 r
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB03080
initial amount: NaN
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
name: Leukotriene D4
constant: false
is: CHEBI:28666
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_e894a4a7_42a7_4ab5_bec2_28542b0d3825
is encoded by: hsa:593
has part: P11182
has part: B4DP47
constant: false
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:594
is encoded by: hsa:1629
name: DBT:DLD:BCKDHA:BCKDHB
boundary condition: true
has part: P21953
type: Species
has only substance units: false
initial concentration: NaN

metaR TYRTAm
name: tyrosine transaminase, mitochondrial
type: Reaction
product: MODEL1310110026#
is: SBO:0000176
reactant: MODEL1310110026#
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.6.1.5
fast: false
notes: GENE_ASSOCIATION: (6898.1) or (2806.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: PMID:1973834 NOTES:NCD
kinetic law: MODEL1310110026#
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.1
is described by: ECO:0000269

metaM elaid c
initial amount: NaN
is: HMDB00573
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9+ HEPATONET_1.0_ABBREVIATION: HC00830
type: Species
is: CHEBI:30825
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
name: elaidate
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_b593d30c_1e32_4d18_b34c_9528842e5347
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:U37519
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
name: _U37519_1_m

metaM cysam c
initial concentration: 1.0
is: HMDB02991
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:58029
name: cysteaminium

metaM spmd e
type: Species
is: C00315
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:57834
name: Spermidine
is: SBO:0000247
boundary condition: false
is: HMDB01257

metaR CORE2GTg
kinetic law: MODEL1310110026#
is: SBO:0000176
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.102
modifier: MODEL1310110026#
reactant: MODEL1310110026#
product: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: (9245.1) or (2650.1) or (51301.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:10753916,PMID:9915862 NOTES:NCD

metaR RE2625M
is version of: http://identifiers.org/ec-code/1.14.13.15
reversible: true
is described by: ECO:0000000
name: RE2625
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
product: MODEL1310110026#
kinetic law: MODEL1310110026#
type: Reaction
reactant: MODEL1310110026#
is: SBO:0000176
fast: false
modifier: MODEL1310110026#

metaR GAMt1r
product: MODEL1310110026#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (6513.1) or (6517.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:
modifier: MODEL1310110026#
reactant: MODEL1310110026#
type: Reaction
kinetic law: MODEL1310110026#
fast: false
is described by: ECO:0000269
name: glucosamine transport (uniport)

metaM xol7aone m
has only substance units: false
is: HMDB01993
constant: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: 7alpha-hydroxycholest-4-en-3-one
is: CHEBI:17899
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_56394c4a_24da_45bc_93e2_d08c7c17cfea
is: Q9Y259
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1120
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
name: CHKB
boundary condition: true

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_b7d57d65_3e94_44ba_bf95_67f38864f0dd
is: Q9Y2Z9
is encoded by: hsa:51004
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
name: COQ6
initial amount: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_ee8b4ecd_4e78_4d5f_b5a1_0a1f7b6234a7
name: NDUFS7
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is: O75251
has only substance units: false
is encoded by: hsa:374291

metaR r1656
is described by: ECO:0000000
type: Reaction
reversible: true
kinetic law: MODEL1310110026#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
modifier: MODEL1310110026#
reactant: MODEL1310110026#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110026#

metaM gdp g
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
name: GDP(3-)
type: Species
is: HMDB01201
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:58189
is: SBO:0000247

metaR ADPtx
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
is described by: ECO:0000000
kinetic law: MODEL1310110026#
fast: false
reversible: true
reactant: MODEL1310110026#
type: Reaction
is: SBO:0000185
name: ADP transporter, peroxisomal

metaM glc D r
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:4167
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
has only substance units: false
is: SBO:0000247
is: HMDB00122
name: D-glucose
boundary condition: false
type: Species

metaR C160CPT1
name: production of Palmitoylcarnitine
fast: false
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:
kinetic law: MODEL1310110026#
product: MODEL1310110026#
type: Reaction
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_7ebca085_01a4_4883_8111_b23de2bc27b4
initial amount: NaN
is: Q59EH3
name: ACP1
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:52
constant: false

metaR r1400
fast: false
reversible: false
reactant: MODEL1310110026#
product: MODEL1310110026#
kinetic law: MODEL1310110026#
type: Reaction
is: SBO:0000185
name: Active transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:

metaR UGLCNACtg
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD
product: MODEL1310110026#
name: UDP-GlcNAc Golgi transport via CMP antiport
reversible: true
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
fast: false
is: SBO:0000185
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_deef88e2_c7c6_45eb_93ee_8f2a3b18a14f
constant: false
has only substance units: false
is encoded by: hsa:8703
is: A8K5Z0
boundary condition: true
is: SBO:0000252
type: Species
name: B4GALT3
initial concentration: NaN
initial amount: NaN

metaR r1655
kinetic law: MODEL1310110026#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110026#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110026#
reversible: true
modifier: MODEL1310110026#

metaM HC00342 m
is: SBO:0000247
constant: false
name: cis-aconitate(3-)
boundary condition: false
is: CHEBI:16383
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0

metaR RE0830N
reactant: MODEL1310110026#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/4.2.1.96
kinetic law: MODEL1310110026#
type: Reaction
name: RE0830
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110026#

metaM idour e
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
is: CHEBI:21338
has only substance units: false
is: HMDB02704
name: L-iduronate
constant: false
initial concentration: 1.0
boundary condition: false

metaM bhb e
type: Species
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:10983
initial amount: NaN
is: HMDB00011
is: SBO:0000247
name: (R)-3-hydroxybutyrate

metaM dmhptcrn c
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
boundary condition: false
initial amount: NaN
constant: false
type: Species
name: 2,6 dimethylheptanoyl carnitine
is: SBO:0000247
is: HMDB06320

metaR KSII CORE4t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
fast: false
product: MODEL1310110026#
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
name: keratan sulfate II (core4) transport, golgi to extracellular
type: Reaction
is: SBO:0000185
is described by: ECO:0000000

metaM alpam m
boundary condition: false
type: Species
is: HMDB06239
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
name: S-aminomethyldihydrolipoamide
is: SBO:0000247
notes: FORMULA: C9H21N2OS2 CHARGE: 1 INCHI: InChI=1/C9H20N2OS2/c10-7-14-6-5-8(13)3-1-2-4-9(11)12/h8,13H,1-7,10H2,(H2,11,12)

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

metaM cholcoads x
is: CHEBI:27505
is: HMDB06889
type: Species
is: SBO:0000247
notes: FORMULA: C48H74N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h9,23-25,27-34,36,38-40,44,56-58,60-61H,7-8,10-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01466 EHMN_ABBREVIATION: C05460
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA
boundary condition: false

metaR IPDDIx
fast: false
kinetic law: MODEL1310110026#
is described by: ECO:0000134
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (3422.1) or (91734.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.3.2
reactant: MODEL1310110026#
modifier: MODEL1310110026#
name: isopentenyl-diphosphate D-isomerase
type: Reaction

metaR UAGDP
reversible: false
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.7.23
is: SBO:0000176
product: MODEL1310110026#
fast: false
type: Reaction
name: UDP-N-acetylglucosamine diphosphorylase

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_45a7a5b3_4b92_4994_bf7f_003ce4f8da26
is: SBO:0000252
name: LPL
is: P06858
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:4023
initial concentration: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_fa731b24_a915_4873_aa39_85ffece8f08e
boundary condition: true
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: MBOAT2
is encoded by: hsa:129642
initial amount: NaN
is: Q6ZWT7

metaM gdp e
boundary condition: false
constant: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: CHEBI:58189
is: HMDB01201
name: GDP(3-)
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false

metaR r1559
is: SBO:0000185
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110026#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110026#
kinetic law: MODEL1310110026#

metaM o2s n
is: CHEBI:18421
constant: false
name: superoxide
boundary condition: false
initial amount: NaN
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
has only substance units: false
is: HMDB02168
initial concentration: 1.0
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110026#_c72f10eb_a238_4b28_9b8b_dd8aa64bde13
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is encoded by: hsa:LOC374569
is: SBO:0000252
initial amount: NaN
name: _LOC374569_1_e
has only substance units: false

metaR ARGtm
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
name: arginine mitochondrial transport via ornithine carrier
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
reversible: true
is described by: ECO:0000269
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110026#
modifier: MODEL1310110026#

metaR SPH1Pte
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
reactant: MODEL1310110026#
product: MODEL1310110026#
reversible: true
is described by: ECO:0000000
name: sph1p transport
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110026#

metaR S4TASE4ly
reversible: true
is: SBO:0000176
product: MODEL1310110026#
name: N-acetylgalactosamine-4-sulfatase, lysosomal
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.1.6.12
fast: false
is described by: ECO:0000000
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_0f52a6fe_7bc1_4834_9cc7_e61d49dbeaca
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4056
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
name: LTC4S
constant: false

metaR r1658
modifier: MODEL1310110026#
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110026#
product: MODEL1310110026#

metaR RE2972M
product: MODEL1310110026#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
name: RE2972
is described by: ECO:0000000
fast: false
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.7.1.67
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110026#_5aacfc64_9fce_45b2_b1b7_47c8664ecc51
is encoded by: hsa:8613
is: O14495
constant: false
name: PPAP2B
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_cf93fed2_427c_4981_bb05_8ebb11cc5105
is: SBO:0000252
constant: false
name: ALDH4A1
is: P30038
has only substance units: false
is encoded by: hsa:8659
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaM c6dc c
has only substance units: false
is: SBO:0000247
name: adipoyl carnitine
type: Species
initial amount: NaN
is: HMDB13130
initial concentration: 1.0
notes: FORMULA: C13H22NO6 CHARGE: -1
constant: false
boundary condition: false

metaM bhb c
is: CHEBI:10983
initial concentration: 1.0
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
name: (R)-3-hydroxybutyrate
initial amount: NaN
is: HMDB00011
constant: false

metaM ksi pre7 g
name: keratan sulfate I biosynthesis, precursor 7
constant: false
initial concentration: 1.0
is: CHEBI:58053
notes: FORMULA: C115H187N8O85SX CHARGE: -2
boundary condition: false
has only substance units: false
is: HMDB00175
is: C00130
type: Species
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110026#_8fa23ccc_8b11_487f_823a_54c5bf21902a
is: SBO:0000252
type: Species
initial amount: NaN
is: Q10472
boundary condition: true
name: GALNT1
is encoded by: hsa:2589
constant: false
initial concentration: NaN
has only substance units: false

metaR CYTK13n
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
name: cytidylate kinase (dCMP,dATP),nuclear
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: true
is described by: ECO:0000269
product: MODEL1310110026#

metaM idour c
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
name: L-iduronate
constant: false
boundary condition: false
initial amount: NaN
is: HMDB02704
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:21338
has only substance units: false

metaR r1657
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#
product: MODEL1310110026#
fast: false
is: SBO:0000185
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_e13f204a_402e_4a72_afb2_864737658034
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
type: Species
is encoded by: hsa:5151
initial amount: NaN
is: SBO:0000252
name: PDE8A

metaM stcoa c
boundary condition: false
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
is: CHEBI:57394
initial concentration: 1.0
has only substance units: false
name: Stearoyl-CoA (n-C18:0CoA)
is: HMDB01114
is: C00412
initial amount: NaN

metaM dmhptcrn e
initial concentration: 1.0
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
name: 2,6 dimethylheptanoyl carnitine
is: HMDB06320

metaR r2387
is described by: ECO:0000000
reactant: MODEL1310110026#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: false
fast: false
product: MODEL1310110026#
kinetic law: MODEL1310110026#
type: Reaction
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
modifier: MODEL1310110026#

metaR AKGMALtm
reversible: true
product: MODEL1310110026#
reactant: MODEL1310110026#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
kinetic law: MODEL1310110026#
fast: false
modifier: MODEL1310110026#
is: SBO:0000185
name: alpha-ketoglutarate/malate transporter

http://identifiers.org/biomodels.db/MODEL1310110026#_02fe7a5c_28b7_4db1_adda_85893495d8f3
is: SBO:0000252
type: Species
constant: false
name: CDO1
is: Q16878
has only substance units: false
is encoded by: hsa:1036
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaM em2emgacpail hs r
is: HMDB03125
is: SBO:0000247
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2 CHARGE: 0
type: Species
boundary condition: false
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol (H7)
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:16240

metaR NDP7g
kinetic law: MODEL1310110026#
is: SBO:0000176
fast: false
reversible: false
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD
modifier: MODEL1310110026#
type: Reaction
product: MODEL1310110026#
is described by: ECO:0000269
name: nucleoside-diphosphatase (UDP), Golgi apparatus
is version of: http://identifiers.org/ec-code/3.6.1.6

http://identifiers.org/biomodels.db/MODEL1310110026#_22f4b814_e455_4ba0_b4f2_5e5d80a30e4b
initial amount: NaN
name: NDUFB5
is: O43674
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4711
constant: false
initial concentration: NaN
boundary condition: true
type: Species

metaM accoa m
is: CHEBI:57288
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
constant: false
is: HMDB01206
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: C00024
has only substance units: false
type: Species
initial amount: NaN
name: Acetyl-CoA

metaM crvnc e
is: HMDB02183
is: CHEBI:36005
notes: FORMULA: C22H31O2 CHARGE: -1
is: SBO:0000247
name: cervonic acid, C22:6 n-3
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN

metaR H2O2tn
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:it
fast: false
reversible: true
kinetic law: MODEL1310110026#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110026#
is: SBO:0000185
name: hydrogen peroxide nuclear transport

http://identifiers.org/biomodels.db/MODEL1310110026#_f21d8783_832a_4dd7_8b4a_77347616bed6
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
name: BTD
is: P43251
is encoded by: hsa:686

metaM lac L e
has only substance units: false
initial amount: NaN
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
is: SBO:0000247
name: (S)-lactate
constant: false
type: Species
is: CHEBI:16651
is: HMDB00190
initial concentration: 1.0
boundary condition: false

metaM dcholcoa x
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB06292
initial amount: NaN
name: chenodeoxycholoyl coenzyme a
is: CHEBI:28701

http://identifiers.org/biomodels.db/MODEL1310110026#_7a976cbf_fc02_49b7_93a3_7b2f376f4e34
boundary condition: true
is: SBO:0000252
constant: false
type: Species
name: SLC2A9
has only substance units: false
is encoded by: hsa:56606
initial amount: NaN
initial concentration: NaN

metaM ksi deg12 l
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00143
notes: FORMULA: C174H279N12O153S9 CHARGE: -9
name: keratan sulfate I, degradation product 12
has only substance units: false
is: CHEBI:12936
boundary condition: false
is: SBO:0000247

metaR MTHFDm
reactant: MODEL1310110026#
fast: false
is: SBO:0000176
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
type: Reaction
is described by: ECO:0000269
product: MODEL1310110026#
reversible: true
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/6.3.4.3
is version of: http://identifiers.org/ec-code/3.5.4.9
modifier: MODEL1310110026#

metaR r2386
reversible: false
type: Reaction
fast: false
modifier: MODEL1310110026#
product: MODEL1310110026#
is described by: ECO:0000000
kinetic law: MODEL1310110026#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
reactant: MODEL1310110026#

metaR RPE
name: ribulose 5-phosphate 3-epimerase
is version of: http://identifiers.org/ec-code/5.1.3.1
modifier: MODEL1310110026#
reactant: MODEL1310110026#
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110026#
fast: false
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP

metaR FAOXC12DCc
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: formation of dodecanedioyl carnitine
type: Reaction

metaR EX HC02203 LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-a2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_cc76b737_7422_43d2_b506_6118e28d28bf
boundary condition: true
type: Species
has part: P21912
is encoded by: hsa:6392
is encoded by: hsa:6390
is encoded by: hsa:6391
has part: Q99643
initial amount: NaN
has part: O14521
is encoded by: hsa:6389
name: SDHA:SDHB:SDHC:SDHD
has part: P31040
is: SBO:0000297
constant: false
has only substance units: false
initial concentration: NaN

metaR AKR1D2
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
fast: false
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110026#
type: Reaction
is: SBO:0000176
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.3.1.3
reactant: MODEL1310110026#
modifier: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_5c71dbdc_301a_4560_ac08_95612db4fd61
initial concentration: NaN
type: Species
has only substance units: false
name: UPB1
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:51733
is: B3KNC1

metaR q10tm
reactant: MODEL1310110026#
name: transport of ubiquinone into mitochondria
is described by: ECO:0000134
reversible: true
fast: false
kinetic law: MODEL1310110026#
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_571996ab_1d42_4588_91f0_0f46efa40c82
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:4697
initial amount: NaN
is: O00483
name: NDUFA4
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_7f3aaa18_2c50_4926_9c00_c2dc9f7dbe17
has only substance units: false
boundary condition: true
initial amount: NaN
is: Q8N142
initial concentration: NaN
is encoded by: hsa:122622
is: SBO:0000252
constant: false
name: ADSSL1
type: Species

metaM 44mctr r
has only substance units: false
is: SBO:0000247
type: Species
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:17813
constant: false
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
is: HMDB01023

metaR PItg
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
reversible: false
is: SBO:0000185
type: Reaction
name: phosphate transport, Golgi apparatus
product: MODEL1310110026#
is described by: ECO:0000000

metaM HC01231 c
initial concentration: 1.0
is: CHEBI:58480
boundary condition: false
constant: false
name: N-[(R)-pantothenoyl]-L-cysteinate
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079

metaR RE0453C
is: SBO:0000176
name: RE0453
reactant: MODEL1310110026#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
type: Reaction
product: MODEL1310110026#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110026#

metaR 3SALAASPm
kinetic law: MODEL1310110026#
is: SBO:0000185
modifier: MODEL1310110026#
type: Reaction
is described by: ECO:0000304
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (10165.1) or (8604.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:PMID:486467 MM
fast: false
reactant: MODEL1310110026#
name: cysteinesulfinate-aspartate mitochondrial shuttle
reversible: true

metaM co e
type: Species
initial concentration: 1.0
name: carbon monoxide
constant: false
is: CHEBI:17245
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB01361
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237

metaR r2385
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110026#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: false
modifier: MODEL1310110026#
reactant: MODEL1310110026#
fast: false
kinetic law: MODEL1310110026#

metaR GALASE7ly
fast: false
type: Reaction
modifier: MODEL1310110026#
reactant: MODEL1310110026#
reversible: false
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110026#_7cce87b9_d963_4b16_a8f3_94be184c86ee
constant: false
is encoded by: hsa:29968
name: PSAT1
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR EX xyl D LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Xylose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_e270ca98_87b8_4503_9c16_c17c429c749f
is encoded by: hsa:518
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
name: ATP5G3
type: Species
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110026#_02ec3874_5aff_4790_adea_d7fe410598ea
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:4714
is: SBO:0000252
is: O95169
has only substance units: false
constant: false
type: Species
name: NDUFB8

http://identifiers.org/biomodels.db/MODEL1310110026#_426323a9_7624_4572_90f8_ec881576e2af
constant: false
is: Q9NXB9
name: ELOVL2
is: SBO:0000252
has only substance units: false
is encoded by: hsa:54898
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR Coqe
is: SBO:0000185
product: MODEL1310110026#
type: Reaction
is described by: ECO:0000134
name: Transport of q10
reversible: true
fast: false
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR EX strch2 LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})
type: Reaction

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

metaM phyt x
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
has only substance units: false
constant: false
is: CHEBI:37257
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00801
name: phytanate
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_dccd9cf5_d29c_4cf6_ab74_cfe1bd320077
has only substance units: false
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
name: PDE8A
boundary condition: true
is encoded by: hsa:5151
is: SBO:0000252

metaM cyan c
initial concentration: 1.0
is: HMDB02084
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:18407
type: Species
is: SBO:0000247
name: hydrogen cyanide
boundary condition: false
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326

metaR r2384
is: SBO:0000185
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
product: MODEL1310110026#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110026#
fast: false
kinetic law: MODEL1310110026#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR FATP1t
reactant: MODEL1310110026#
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (376497.2) or (10999.1) or (376497.1) or (11000.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816,PMID:9878842 NOTES:electroneutral transport NJ
modifier: MODEL1310110026#
reversible: true
is described by: ECO:0000269
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110026#
name: fatty acid electroneutral transport

metaM ksi pre10 g
is: C00130
type: Species
name: keratan sulfate I biosynthesis, precursor 10
is: CHEBI:58053
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00175
notes: FORMULA: C129H209N9O98S2X CHARGE: -3
has only substance units: false

metaR EX octa LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoate (n-C8:0)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110026#_379a4f7b_1054_4952_8b0a_374c27ff119d
name: NOS1
initial concentration: NaN
is encoded by: hsa:4842
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: B4DG68
type: Species
constant: false

metaR r0287
reversible: false
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110026#
modifier: MODEL1310110026#
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
product: MODEL1310110026#
is described by: ECO:0000000

metaM adrn e
initial amount: NaN
is: HMDB02226
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
is: SBO:0000247
constant: false
has only substance units: false
name: adrenic acid
type: Species
initial concentration: 1.0
is: CHEBI:53487
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110026#_6e8efb0b_4299_47cc_ab7c_817a01f67ede
has part: Q06055
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000297
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2
constant: false
is encoded by: hsa:517
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_f14a19a5_d89b_44e3_b304_d3ca65507ecc
initial concentration: NaN
type: Species
is: SBO:0000252
is: E9PB82
is encoded by: hsa:3295
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
name: HSD17B4

metaM xolest2 hs e
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
constant: false
initial concentration: 1.0
has only substance units: false
name: cholesterol ester
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:17002

metaM leuktrD4 c
is: SBO:0000247
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
constant: false
has only substance units: false
type: Species
is: CHEBI:28666
boundary condition: false
name: Leukotriene D4
initial amount: NaN
is: HMDB03080
initial concentration: 1.0

metaM arachdcoa c
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
type: Species
boundary condition: false
is: HMDB06523
name: arachidonoyl-CoA(4-)
initial concentration: 1.0
has only substance units: false
is: CHEBI:57368

http://identifiers.org/biomodels.db/MODEL1310110026#_c7748d0f_2fe4_4b9d_be5c_a1eb1f3e9a61
is encoded by: hsa:204
initial amount: NaN
has only substance units: false
type: Species
name: AK2
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
is: P54819

metaM co c
is: HMDB01361
name: carbon monoxide
has only substance units: false
type: Species
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:17245
is: SBO:0000247
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
initial concentration: 1.0

metaM c4dc x
type: Species
is: HMDB02013
initial concentration: 1.0
notes: FORMULA: C11H18NO6 CHARGE: -1
constant: false
has only substance units: false
is: C02862
initial amount: NaN
is: SBO:0000247
name: succinyl carnitine
boundary condition: false
is: http://identifiers.org/pubchem.compound/213144

metaR SUCCOAPET
kinetic law: MODEL1310110026#
product: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of succinyl coa for release into cytosol
type: Reaction

metaR DOLMANP Uter
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
name: dolichol-phosphate mannose flippase (uterus)
fast: false
reactant: MODEL1310110026#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110026#
reversible: false
product: MODEL1310110026#

metaM 34dhphe e
name: L-dopa
notes: FORMULA: C9H11NO4 CHARGE: 0 INCHI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB00181
boundary condition: false
initial amount: NaN
is: CHEBI:15765
initial concentration: 1.0
constant: false

metaR FADH2ETC
is: SBO:0000176
is described by: ECO:0000134
kinetic law: MODEL1310110026#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: false
product: MODEL1310110026#
reactant: MODEL1310110026#
name: Complex II reaction for respiratory chain
type: Reaction

metaR r0391
reversible: true
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
type: Reaction
name: Nicotinate D-ribonucleotide:pyrophosphate phosphoribosyltransferase Nicotinate and nicotinamide metabolism EC:2.4.2.11
product: MODEL1310110026#
fast: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 2.4.2.11 Confidence Level: 0 AUTHORS: PMID:17604275 NOTES:

metaM cyan e
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
is: SBO:0000247
is: CHEBI:18407
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
name: hydrogen cyanide
is: HMDB02084
has only substance units: false

metaR ADRNCOAtx
name: fatty acid intracellular transport
kinetic law: MODEL1310110026#
type: Reaction
fast: false
reactant: MODEL1310110026#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

metaR CHOLESTle
name: hydrolysis of cholesterol ester by cholesterol esterase
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (3988.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110026#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.1.1.13
type: Reaction
modifier: MODEL1310110026#
reactant: MODEL1310110026#
is: SBO:0000176
is described by: ECO:0000134

metaM ditp c
name: dITP(4-)
is: CHEBI:61382
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB03537

metaR r2382
product: MODEL1310110026#
modifier: MODEL1310110026#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110026#
reversible: false
fast: false
kinetic law: MODEL1310110026#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaM adrn c
initial concentration: 1.0
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
constant: false
initial amount: NaN
name: adrenic acid
is: CHEBI:53487
type: Species
boundary condition: false
is: HMDB02226
has only substance units: false
is: SBO:0000247

metaM o2s x
initial amount: NaN
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: HMDB02168
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:18421
name: superoxide
boundary condition: false
is: SBO:0000247
constant: false

metaM 34dhphe c
is: CHEBI:15765
notes: FORMULA: C9H11NO4 CHARGE: 0 INCHI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
boundary condition: false
constant: false
name: L-dopa
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB00181
initial amount: NaN
initial concentration: 1.0

metaR EX fucacgalfucgalacglcgalgluside hs LPAREN e RPAREN
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (Gal)2 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)2 (Cer)1 exchange
type: Reaction

metaM CE0693 m
is: SBO:0000247
initial concentration: 1.0
name: 3-oxolaur-6-cis-enoyl-CoA
is: CHEBI:28387
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: HMDB11123
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
boundary condition: false

metaR BTND1
reversible: false
reactant: MODEL1310110026#
name: biotinidase (biotin)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:IT
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110026#
fast: false
product: MODEL1310110026#
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.5.1.12

http://identifiers.org/biomodels.db/MODEL1310110026#_5d2823d8_a79e_4500_8f6c_d9a5a7848cd9
is: Q16790
type: Species
is encoded by: hsa:768
name: CA9
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_85e754cc_7515_47ed_8d16_b092e5a70bd6
is: O75610
initial concentration: NaN
initial amount: NaN
type: Species
name: LEFTY1
is encoded by: hsa:10637
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252

metaM succ c
name: Succinate
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB00254
type: Species
is: C00042
is: CHEBI:30031
initial amount: NaN
initial concentration: 1.0

metaM Rtotal3 e
initial amount: NaN
is: C00255
name: R total 3 position
has only substance units: false
notes: FORMULA: CO2FULLR3 CHARGE: -1
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB00244
constant: false
is: CHEBI:3554
is: SBO:0000247

metaM adpcoa x
is: C14143
is: HMDB04047
initial concentration: 1.0
name: adipoylcoa
has only substance units: false
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species

metaR r0390
reversible: true
type: Reaction
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110026#
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#

metaR FAOXC16080m
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110026#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176
name: Beta oxidation of long chain fatty acid
reactant: MODEL1310110026#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110026#

metaM dcholcoa r
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
is: HMDB06292
is: CHEBI:28701
type: Species
name: chenodeoxycholoyl coenzyme a
initial concentration: 1.0

metaM leuktrD4 e
is: SBO:0000247
constant: false
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
type: Species
has only substance units: false
is: CHEBI:28666
initial amount: NaN
boundary condition: false
is: HMDB03080
name: Leukotriene D4
initial concentration: 1.0

metaM gdp n
is: HMDB01201
type: Species
initial amount: NaN
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58189
name: GDP(3-)
boundary condition: false
has only substance units: false

metaR RPI
kinetic law: MODEL1310110026#
name: ribose-5-phosphate isomerase
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/5.3.1.6
is described by: ECO:0000000
reversible: true
is: SBO:0000176
modifier: MODEL1310110026#
reactant: MODEL1310110026#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP

metaM arachcoa m
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
initial concentration: 1.0
constant: false
is: CHEBI:15527
is: HMDB04258
initial amount: NaN
name: arachidyl coenzyme A

http://identifiers.org/biomodels.db/MODEL1310110026#_343a2e48_0f6d_4501_864b_cdcc9e9f094a
boundary condition: true
initial amount: NaN
has only substance units: false
name: _C7orf24_1_m
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:C7orf24

http://identifiers.org/biomodels.db/MODEL1310110026#_e8c14958_cc87_4143_b8d8_08d1672c8d67
constant: false
is encoded by: hsa:10588
type: Species
initial amount: NaN
name: MTHFS
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: P49914

metaM q10h2 c
type: Species
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
is: HMDB13111
boundary condition: false
constant: false
has only substance units: false
name: Ubiquinol-10
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/6504740

metaM lac L c
name: (S)-lactate
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB00190
type: Species
has only substance units: false
is: CHEBI:16651

http://identifiers.org/biomodels.db/MODEL1310110026#_2f5809db_1d94_475a_a147_f1248ecdfae6
constant: false
initial concentration: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
is encoded by: hsa:522
has part: P56134
has only substance units: false
boundary condition: true
is encoded by: hsa:9551
initial amount: NaN
is: SBO:0000297
type: Species

metaR H2O2tp
is described by: ECO:0000000
product: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: true
name: hydrogen peroxide peroxisomal transport via diffusion
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110026#_06683ccb_7e54_4a80_b134_791b3e7a9dcc
constant: false
initial amount: NaN
is: O14939
boundary condition: true
has only substance units: false
type: Species
name: PLD2
is: SBO:0000252
is encoded by: hsa:5338
initial concentration: NaN

metaM gdp m
boundary condition: false
is: CHEBI:58189
is: HMDB01201
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: C00035
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
has only substance units: false
name: GDP
initial amount: NaN

metaR CH25H
kinetic law: MODEL1310110026#
is: SBO:0000176
reactant: MODEL1310110026#
name: cholesterol 25-hydroxylase
reversible: false
modifier: MODEL1310110026#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.14.99.38
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (9023.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269

metaR r2380
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: true
product: MODEL1310110026#

metaM ksi pre18 g
has only substance units: false
constant: false
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 18
is: HMDB00175
is: SBO:0000247
type: Species
notes: FORMULA: C163H262N11O132S5X CHARGE: -6
is: C00130
is: CHEBI:58053
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110026#_88af20e7_f9a5_4721_9348_5e90b8d0fdb6
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
is: Q8WVQ1
is encoded by: hsa:124583
is: SBO:0000252
constant: false
name: CANT1

metaM accoa n
constant: false
initial amount: NaN
boundary condition: false
type: Species
name: acetyl-CoA(4-)
is: HMDB01206
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: CHEBI:57288
has only substance units: false

metaM Rtotal3 c
boundary condition: false
type: Species
initial amount: NaN
is: HMDB01448
is: CHEBI:16189
notes: FORMULA: CO2FULLR3 CHARGE: -1
constant: false
initial concentration: 1.0
name: R total 3 position
is: SBO:0000247
has only substance units: false

metaR r0497
fast: false
type: Reaction
modifier: MODEL1310110026#
is version of: http://identifiers.org/ec-code/1.2.4.2
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
is: SBO:0000176
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
reactant: MODEL1310110026#
product: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: true
is described by: ECO:0000000

metaM leuktrF4 c
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: leukotriene F4
constant: false
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
initial concentration: 1.0
type: Species
is: HMDB06465
has only substance units: false
is: CHEBI:27491

http://identifiers.org/biomodels.db/MODEL1310110026#_6f3bf13b_3f4c_4ffc_aaf0_dea87274ed90
has only substance units: false
name: PLCD4
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:84812
is: Q9BRC7
boundary condition: true
initial concentration: NaN

metaM q10h2 e
boundary condition: false
is: http://identifiers.org/pubchem.compound/6504740
type: Species
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
name: Ubiquinol-10
is: SBO:0000247
is: HMDB13111
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR RE0926E
reversible: true
type: Reaction
name: RE0926
is version of: http://identifiers.org/ec-code/3.2.1.1
reactant: MODEL1310110026#
modifier: MODEL1310110026#
is described by: ECO:0000000
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.17
product: MODEL1310110026#
kinetic law: MODEL1310110026#

metaM andrstandn r
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:15994
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
type: Species
is: HMDB00899
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
name: 5alpha-androstane-3,17-dione

metaR CORE4GTg
name: Core 4 beta6-GalNAc-transferase, Golgi apparatus
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.102
reactant: MODEL1310110026#
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (9245.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.148 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
fast: false
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#

metaR r0395
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:11993848,PMID:1643670,PMID:3010873,PMID:8343533 NOTES:
is described by: ECO:0000000
is: SBO:0000176
reversible: true
name: Hypoxanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
product: MODEL1310110026#
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_e01d16fe_b90b_4e8d_a2fc_2cba81c9c490
initial amount: NaN
is: P40879
is encoded by: hsa:1811
is: SBO:0000252
name: SLC26A3
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
constant: false

metaR r1560
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110026#
is: SBO:0000185
kinetic law: MODEL1310110026#
type: Reaction

metaR S6T12g
notes: GENE_ASSOCIATION: (23563.1) or (9435.1) or (10164.1) or (4166.1) or (23563.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
reversible: false
fast: false
modifier: MODEL1310110026#
is described by: ECO:0000000
reactant: MODEL1310110026#
kinetic law: MODEL1310110026#
product: MODEL1310110026#
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110026#_ec2da045_b798_46a6_80f1_92979be5191d
has only substance units: false
is: SBO:0000252
is: P35557
name: GCK
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2645
constant: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110026#_005fee44_a57a_4d8f_bdd5_51b57a18c1e1
has only substance units: false
is: SBO:0000252
is: P23921
type: Species
name: RRM1
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:6240
initial concentration: NaN

metaR r0394
product: MODEL1310110026#
type: Reaction
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
kinetic law: MODEL1310110026#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
reversible: true
reactant: MODEL1310110026#
fast: false

metaR RE3218C
type: Reaction
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
is: SBO:0000176
product: MODEL1310110026#
reversible: true
is described by: ECO:0000000
name: RE3218
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.2
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_2a67d98c_cf57_4080_92d1_cb1ca5a0210a
is encoded by: hsa:2181
is: SBO:0000252
type: Species
has only substance units: false
name: ACSL3
is: B3KMA6
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaM sbcoa x
is: SBO:0000247
is: HMDB02014
initial amount: NaN
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
name: suberylcoa
boundary condition: false
type: Species
has only substance units: false
constant: false
initial concentration: 1.0

metaM c6dc x
has only substance units: false
is: C14143
boundary condition: false
name: adipoyl carnitine
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB04047
type: Species
constant: false
notes: FORMULA: C13H22NO6 CHARGE: -1

metaR CGLYt3 2
is described by: ECO:0000304
reversible: false
reactant: MODEL1310110026#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB
fast: false
kinetic law: MODEL1310110026#
name: Cys-Gly transport in via proton symport
modifier: MODEL1310110026#
product: MODEL1310110026#
type: Reaction

metaM nadp c
constant: false
is: C00006
name: Nicotinamide adenine dinucleotide phosphate
initial concentration: 1.0
is: HMDB00217
is: SBO:0000247
is: CHEBI:58349
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
initial amount: NaN

metaR r1561
type: Reaction
reversible: true
kinetic law: MODEL1310110026#
is: SBO:0000185
product: MODEL1310110026#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_a12fd458_5cf2_4fc1_9566_af1f3d5f6e02
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:5279
name: PIGC
boundary condition: true

metaM leuktrF4 e
is: HMDB06465
is: CHEBI:27491
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
name: leukotriene F4
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110026#_38f77615_ca15_4e54_822a_1ec14bd21267
type: Species
initial concentration: NaN
initial amount: NaN
name: ATP2B4
is encoded by: hsa:493
has only substance units: false
is: SBO:0000252
constant: false
is: P23634
boundary condition: true

metaR r0393
reversible: false
kinetic law: MODEL1310110026#
type: Reaction
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
modifier: MODEL1310110026#
fast: false
reactant: MODEL1310110026#
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.74
product: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_37d63492_a04a_430b_a956_cf741310ab6b
is encoded by: hsa:157570
type: Species
is: Q56NI9
initial concentration: NaN
name: ESCO2
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110026#_43f7e057_f24a_4f25_8637_c4025c1829e6
type: Species
has only substance units: false
is encoded by: hsa:9963
is: SBO:0000252
constant: false
initial amount: NaN
name: SLC23A1
boundary condition: true
initial concentration: NaN

metaM dmpp x
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h3H,4H2,1-2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00213 EHMN_ABBREVIATION: C00235
is: HMDB01120
is: CHEBI:57623
constant: false
initial concentration: 1.0
name: prenyl diphosphate(3-)
type: Species
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110026#_eb3ad701_138f_456c_a9f1_7ca05dfc27d2
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:5860
is: P09417
type: Species
constant: false
name: QDPR
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110026#_2432954c_0910_41fd_9b8f_0542169fb2b6
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:R06874
has only substance units: false
boundary condition: true
is: SBO:0000252
name: _R06874_1_r

metaR RE1519M
reactant: MODEL1310110026#
name: RE1519
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.13
reversible: true
modifier: MODEL1310110026#
is: SBO:0000176
kinetic law: MODEL1310110026#
product: MODEL1310110026#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.3.6
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110026#_96f73a90_5790_4fba_b904_80535cf9cea8
is: Q9NT06
name: HMGCLL1
has only substance units: false
is: SBO:0000252
is encoded by: hsa:54511
constant: false
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN

metaR SMPD4
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ
type: Reaction
is: SBO:0000176
name: sphingomyelinase
kinetic law: MODEL1310110026#
fast: false
is described by: ECO:0000000
product: MODEL1310110026#
reversible: false

metaR r0392
fast: false
product: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
type: Reaction
kinetic law: MODEL1310110026#
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
is described by: ECO:0000000
is: SBO:0000176
reversible: true

metaR ADSS
reactant: MODEL1310110026#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/6.3.4.4
is described by: ECO:0000134
product: MODEL1310110026#
name: adenylosuccinate synthase
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
type: Reaction
kinetic law: MODEL1310110026#
is: SBO:0000176
modifier: MODEL1310110026#

metaM gdpfuc g
is: CHEBI:57984
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB01095
constant: false
boundary condition: false
initial amount: NaN
name: GDP-L-fucose(2-)
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
initial concentration: 1.0

metaR ECOAH1m
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110026#
reactant: MODEL1310110026#
is version of: http://identifiers.org/ec-code/4.2.1.18
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
is described by: ECO:0000304
fast: false
kinetic law: MODEL1310110026#
type: Reaction
is: SBO:0000176
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)

http://identifiers.org/biomodels.db/MODEL1310110026#_25df948d_487e_4714_afc0_8b2103a26655
is: A0S0A7
initial concentration: NaN
is encoded by: hsa:4846
has only substance units: false
constant: false
type: Species
is: SBO:0000252
boundary condition: true
name: NOS3
initial amount: NaN

metaR NDP7ex
name: nucleoside-diphosphatase (UDP), extracellular
type: Reaction
fast: false
modifier: MODEL1310110026#
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12600208 NOTES:
is version of: http://identifiers.org/ec-code/3.6.1.6
is: SBO:0000176
product: MODEL1310110026#
reversible: false
kinetic law: MODEL1310110026#
is described by: ECO:0000269

metaM HC02187 e
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
constant: false
type: Species
is: CHEBI:28774
boundary condition: false
name: reverse-triiodthyronine

http://identifiers.org/biomodels.db/MODEL1310110026#_96728787_5302_4a9f_bbab_88f4894759ea
name: _AI378339_1_m
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:AI378339
initial concentration: NaN
type: Species
constant: false

metaM ksi deg29 l
is: HMDB00143
initial concentration: 1.0
name: keratan sulfate I, degradation product 29
constant: false
is: CHEBI:12936
notes: FORMULA: C96H157N6O80S3 CHARGE: -3
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaM HC01231 m
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
name: N-[(R)-pantothenoyl]-L-cysteinate
type: Species
is: CHEBI:58480
initial concentration: 1.0

metaM 4abut m
boundary condition: false
constant: false
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
is: HMDB00112
initial concentration: 1.0
type: Species
is: CHEBI:16865
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: C00334
name: 4-Aminobutanoate

metaM ppa e
is: HMDB00237
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
name: propionate
is: SBO:0000247
is: CHEBI:17272

metaR r0399
type: Reaction
product: MODEL1310110026#
reactant: MODEL1310110026#
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:
is version of: http://identifiers.org/ec-code/1.2.4.2
is: SBO:0000176
kinetic law: MODEL1310110026#
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
modifier: MODEL1310110026#

metaM thbpt4acam c
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
is: HMDB02281
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:15374
is: SBO:0000247
type: Species
name: 4a-hydroxytetrahydrobiopterin
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110026#_20aff8f0_539c_4cd4_b818_9fe2a981764a
type: Species
is encoded by: hsa:3158
initial amount: NaN
constant: false
boundary condition: true
is: P54868
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: HMGCS2

metaM pnto R c
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
name: (R)-Pantothenate
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
is: HMDB00210
is: CHEBI:7916
boundary condition: false
is: SBO:0000247
has only substance units: false

metaR S4TASE5ly
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110026#
product: MODEL1310110026#
kinetic law: MODEL1310110026#
is version of: http://identifiers.org/ec-code/3.1.6.12
reversible: true
is: SBO:0000176
name: N-acetylgalactosamine-4-sulfatase, lysosomal
modifier: MODEL1310110026#

metaM so4 m
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:16189
initial amount: NaN
initial concentration: 1.0
is: HMDB01448
boundary condition: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
constant: false
name: sulfate

metaM s2l2n2m2m l
is: SBO:0000247
boundary condition: false
name: de-Fuc form of PA6 (w/o peptide linkage)
initial concentration: 1.0
type: Species
notes: FORMULA: C84H136N6O62 CHARGE: -2
has only substance units: false
initial amount: NaN
is: CHEBI:30825
constant: false
is: HMDB00573

metaR DECDPtm
kinetic law: MODEL1310110026#
is: SBO:0000185
product: MODEL1310110026#
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110026#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:ubiquinone precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is described by: ECO:0000000
name: lipid, flip-flop intracellular transport

metaR RE0453N
is: SBO:0000176
reversible: true
type: Reaction
kinetic law: MODEL1310110026#
name: RE0453
product: MODEL1310110026#
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110026#
fast: false

metaR CITL
modifier: MODEL1310110026#
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
name: Citrate lyase
reactant: MODEL1310110026#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
product: MODEL1310110026#
type: Reaction
fast: false
kinetic law: MODEL1310110026#

metaR SERtN1
reversible: true
name: Serine transport (Na, H coupled)
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110026#
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
fast: false
reactant: MODEL1310110026#
modifier: MODEL1310110026#
kinetic law: MODEL1310110026#

metaM HC01408 m
name: 3-Oxohexanoyl-CoA
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:27648
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269

metaM accoa x
name: Acetyl-CoA
is: CHEBI:57288
initial concentration: 1.0
is: SBO:0000247
is: C00024
initial amount: NaN
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: HMDB01206
constant: false
boundary condition: false
has only substance units: false
type: Species

metaR TETPENT6COAtx
name: fatty acid intracellular transport
is described by: ECO:0000000
product: MODEL1310110026#
kinetic law: MODEL1310110026#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
fast: false
reactant: MODEL1310110026#

metaR HAtly
name: hyaluronan transport, extracellular to lysosome
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
reversible: false
kinetic law: MODEL1310110026#
reactant: MODEL1310110026#
is described by: ECO:0000000
product: MODEL1310110026#

http://identifiers.org/biomodels.db/MODEL1310110026#_73c3fcea_008c_48b9_ba6d_67b8585bf989
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:2530
initial amount: NaN
name: FUT8
has only substance units: false
is: A8K8P8
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110026#_bf15e649_9312_4ea7_b130_a1f3e5c230b7
has only substance units: false
is: Q9NUB1
is: SBO:0000252
name: ACSS1
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:84532
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110026#_04089a76_2a3c_47b3_a8c9_c437e7d2dd06
name: B4GALT2
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
type: Species
is: O60909
has only substance units: false
is encoded by: hsa:8704
initial concentration: NaN

metaM 3mox4hpac m
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:28111
constant: false
notes: FORMULA: C9H10O3 CHARGE: 0 INCHI: InChI=1S/C9H10O3/c1-12-9-6-7(4-5-10)2-3-8(9)11/h2-3,5-6,11H,4H2,1H3 HEPATONET_1.0_ABBREVIATION: HC01518 EHMN_ABBREVIATION: C05581
is: SBO:0000247
initial amount: NaN
is: HMDB05175
name: (4-hydroxy-3-methoxyphenyl)acetaldehyde

metaR r2047
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110026#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110026#
fast: false
product: MODEL1310110026#
is described by: ECO:0000000
reversible: false
is: SBO:0000185
type: Reaction
modifier: MODEL1310110026#

metaM ppa c
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
is: CHEBI:17272
is: HMDB00237
initial amount: NaN
name: propionate
boundary condition: false
has only substance units: false