metaM HC00250 c
name: hydrosulfide
is: CHEBI:29919
has only substance units: false
constant: false
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
initial concentration: 1.0

metaR r2333
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110025#
type: Reaction
fast: false
product: MODEL1310110025#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
kinetic law: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_433eb057_ca51_4fdd_b8f4_b697a36213e8
name: SLC5A8
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:160728
is: Q8N695

http://identifiers.org/biomodels.db/MODEL1310110025#_f043b3f5_74bc_490a_b8c7_f6160788eaab
type: Species
is encoded by: hsa:112724
is: B3KVA3
initial concentration: NaN
has only substance units: false
name: RDH13
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN

metaR DOLPGT3 Uer
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (84920.1) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
reactant: MODEL1310110025#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.256
modifier: MODEL1310110025#
product: MODEL1310110025#
kinetic law: MODEL1310110025#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110025#_7c68a988_4da4_4001_9f3c_163430dbef81
initial amount: NaN
name: RDH8
is encoded by: hsa:50700
has only substance units: false
is: Q9NYR8
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
constant: false

metaR r1631
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_337b2baa_07bc_4a25_be5e_2d543f49e433
boundary condition: true
is: Q9UIG8
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
name: SLCO3A1
is encoded by: hsa:28232

metaM 7thf e
type: Species
constant: false
is: HMDB06559
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: heptaglutamyl folate (THF)
has only substance units: false
initial amount: NaN
notes: FORMULA: C49H57N13O24 CHARGE: -8

http://identifiers.org/biomodels.db/MODEL1310110025#_8d6bced9_4da8_4858_8b66_8a0d61e21fa8
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1716
name: DGUOK
initial amount: NaN
type: Species
boundary condition: true
is: Q16854
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_b1f60539_fb6c_454c_a4a9_8ef51d31da8e
has only substance units: false
boundary condition: true
name: COX4I1
is: SBO:0000252
constant: false
initial amount: NaN
is: P13073
initial concentration: NaN
type: Species
is encoded by: hsa:1327

metaR TSTSTERONEtr
type: Reaction
is: SBO:0000185
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110025#
product: MODEL1310110025#
name: testosterone intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
kinetic law: MODEL1310110025#

metaM HC02187 c
boundary condition: false
type: Species
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
constant: false
has only substance units: false
is: CHEBI:28774
initial concentration: 1.0
name: reverse-triiodthyronine
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110025#_1f519ec9_d493_4894_8157_32c3bd2e3038
initial amount: NaN
initial concentration: NaN
is: P05177
name: CYP1A2
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1544
type: Species
has only substance units: false
constant: false

metaR r2332
reversible: true
reactant: MODEL1310110025#
fast: false
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110025#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR sink pre prot LPAREN r RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycophosphatidylinositol (GPI)-anchored protein precursor sink
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_6931c3ba_0b80_4277_be18_edd39e439062
is encoded by: hsa:1346
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
is: P24310
initial concentration: NaN
name: COX7A1
boundary condition: true

metaM sphs1p c
initial amount: NaN
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
boundary condition: false
type: Species
is: HMDB00277
is: CHEBI:60119
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
name: sphingosine 1-phosphate(1-)

metaR r1632
reactant: MODEL1310110025#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110025#
modifier: MODEL1310110025#

metaM C05279 m
initial amount: NaN
boundary condition: false
type: Species
name: trans,cis-Lauro-2,6-dienoyl-CoA
is: SBO:0000247
constant: false
is: HMDB11123
is: CHEBI:28387
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110025#_a32d492e_0b74_449d_994a_9b7d22ca4b90
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI971036
constant: false
name: _AI971036_1_x

metaM sprm e
type: Species
notes: FORMULA: C10H30N4 CHARGE: 4 INCHI: InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2 HEPATONET_1.0_ABBREVIATION: HC00525 EHMN_ABBREVIATION: C00750
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB01256
boundary condition: false
is: CHEBI:45725
has only substance units: false
name: spermine(4+)

metaR r1855
reactant: MODEL1310110025#
product: MODEL1310110025#
kinetic law: MODEL1310110025#
fast: false
modifier: MODEL1310110025#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
type: Reaction
is described by: ECO:0000000
name: Y+LAT2 Utilized transport

metaM 4ppcys c
initial amount: NaN
is: HMDB01117
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
boundary condition: false
constant: false
is: C04352
initial concentration: 1.0
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
is: CHEBI:59458
type: Species
has only substance units: false
is: SBO:0000247

metaM for c
name: Formate
initial concentration: 1.0
constant: false
is: CHEBI:15740
is: C00058
has only substance units: false
boundary condition: false
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
type: Species
is: HMDB00142
is: SBO:0000247
initial amount: NaN

metaR PHCHGSm
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:taken from KEGG map. No enzyme assigned, so assumed this is a non-enzymatic reaction. NCD
product: MODEL1310110025#
reversible: true
name: L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial
is described by: ECO:0000000
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
type: Reaction
fast: false

metaR r0990
reversible: true
is: SBO:0000185
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110025#
type: Reaction
name: Postulated transport reaction
reactant: MODEL1310110025#

metaR r1380
reversible: true
kinetic law: MODEL1310110025#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
reactant: MODEL1310110025#
product: MODEL1310110025#
fast: false

metaR r2331
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
product: MODEL1310110025#
fast: false
type: Reaction
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110025#
reversible: true
is described by: ECO:0000000

metaR CITL
modifier: MODEL1310110025#
type: Reaction
reactant: MODEL1310110025#
reversible: false
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
kinetic law: MODEL1310110025#
is: SBO:0000176
is described by: ECO:0000000
name: Citrate lyase
product: MODEL1310110025#
fast: false

metaM HC00250 e
is: CHEBI:29919
constant: false
is: SBO:0000247
name: hydrosulfide
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
initial concentration: 1.0

metaM methf c
name: 5,10-Methenyltetrahydrofolate
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB01354
is: CHEBI:57455
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
is: C00445

metaM spmd e
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
type: Species
is: CHEBI:57834
boundary condition: false
name: Spermidine
constant: false
is: HMDB01257
is: C00315
initial amount: NaN
is: SBO:0000247

metaM udp e
name: UDP(3-)
boundary condition: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: HMDB00295
initial concentration: 1.0
is: CHEBI:58223
constant: false
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN

metaM mercppyr c
type: Species
is: CHEBI:57678
initial amount: NaN
boundary condition: false
is: HMDB01368
notes: FORMULA: C3H3O3S CHARGE: -1 INCHI: InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00600 EHMN_ABBREVIATION: C00957
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: 3-mercaptopyruvate
constant: false

metaM dsmsterol r
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17737
name: desmosterol
is: SBO:0000247
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00847 EHMN_ABBREVIATION: C01802
constant: false
type: Species
has only substance units: false
boundary condition: false
is: HMDB02719

metaR ACACT10m
product: MODEL1310110025#
is described by: ECO:0000134
is: SBO:0000176
modifier: MODEL1310110025#
type: Reaction
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
name: acetyl-CoA C-acetyltransferase, mitochondrial
is version of: http://identifiers.org/ec-code/2.3.1.9
reversible: true
fast: false
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency

http://identifiers.org/biomodels.db/MODEL1310110025#_069d31ef_aeb7_44e1_a98f_727cd571ec8d
is: P36969
name: GPX4
constant: false
is encoded by: hsa:2879
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_7e43aba6_4158_4072_ad94_9a32f797e0c0
is: O14495
has only substance units: false
type: Species
name: PPAP2B
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:8613
initial concentration: NaN
constant: false

metaR EX met L LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Methionine exchange
type: Reaction

metaR PSDm hs
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ
is: SBO:0000176
modifier: MODEL1310110025#
is described by: ECO:0000269
product: MODEL1310110025#
name: Phosphatidylserine decarboxylase
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.65
fast: false

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_a8a1e272_3dad_4d9c_bb66_95c56b8af04f
has only substance units: false
initial amount: NaN
name: OCRL
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
boundary condition: true
is: Q01968
is encoded by: hsa:4952

http://identifiers.org/biomodels.db/MODEL1310110025#_b0c9f517_cc25_4cd1_9552_47f0078d7943
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:1635
constant: false
has only substance units: false
is: P32321
name: DCTD

metaM sphs1p e
is: HMDB00277
is: SBO:0000247
has only substance units: false
name: sphingosine 1-phosphate(1-)
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:60119
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
boundary condition: false
constant: false

metaM HC02187 e
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
is: SBO:0000247
has only substance units: false
name: reverse-triiodthyronine
is: CHEBI:28774
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
boundary condition: false

metaR r2330
product: MODEL1310110025#
fast: false
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110025#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
is: SBO:0000185
is described by: ECO:0000000

metaR r1381
reactant: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110025#
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
reversible: true
is: SBO:0000176
type: Reaction

metaR r1630
reactant: MODEL1310110025#
is described by: ECO:0000000
kinetic law: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_26bc6078_b6a8_484f_aecb_d219347b2dc3
has only substance units: false
type: Species
is encoded by: hsa:6342
constant: false
is: C9JC79
initial amount: NaN
is: SBO:0000252
name: SCP2
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110025#_e3882734_6ac7_4c34_8d70_b50cfdcde876
is: Q9H845
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:28976
name: ACAD9
type: Species
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110025#_8f006183_96c8_47bc_93c2_14b4569b49d4
constant: false
initial amount: NaN
type: Species
name: RDH11
is encoded by: hsa:51109
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
is: B4DDW0

metaR IDOURtly
is described by: ECO:0000269
is: SBO:0000185
fast: false
modifier: MODEL1310110025#
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261,PMID:9852127 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 (for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD added IdoA reaction - NCD
name: iduronate transport into lysososme
reversible: true
type: Reaction
product: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_802d06b3_629b_45a3_8684_d3829a419598
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is: Q01581
name: HMGCS1
is encoded by: hsa:3157

metaM sprm c
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:45725
initial concentration: 1.0
initial amount: NaN
type: Species
name: spermine(4+)
notes: FORMULA: C10H30N4 CHARGE: 4 INCHI: InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2 HEPATONET_1.0_ABBREVIATION: HC00525 EHMN_ABBREVIATION: C00750
is: HMDB01256
boundary condition: false

metaM estradiol c
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
type: Species
has only substance units: false
name: estradiol
is: CHEBI:16469
is: HMDB00151
constant: false

metaM for e
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
name: formate
constant: false
initial concentration: 1.0
is: CHEBI:15740
is: HMDB00142
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_9c477140_f27f_425e_8487_cbe2af59882d
constant: false
is encoded by: hsa:93183
name: PIGX:PIGM
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:54965
type: Species
initial amount: NaN
has part: Q8TBF5
has only substance units: false
boundary condition: true
has part: Q9H3S5

metaM c226coa c
is: http://identifiers.org/pubchem.compound/47205479
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: C16169
is: SBO:0000247
initial amount: NaN
name: cervonyl coenzyme A
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110025#_4731c104_371a_44ab_b1c4_10399b5e865e
name: SLC25A19
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
is: Q9HC21
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:60386

metaR ADKd
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.7.4.3
type: Reaction
is: SBO:0000176
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)
name: adenylate kinase (d form)
fast: false

http://identifiers.org/biomodels.db/MODEL1310110025#_f9816008_ec79_4f72_92e9_5439ae01e886
name: CA9
boundary condition: true
is encoded by: hsa:768
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
is: Q16790
initial concentration: NaN

metaR PRO1xm
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:NCD
fast: false
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.5.99.8
reactant: MODEL1310110025#
modifier: MODEL1310110025#
name: proline oxidase (NAD), mitochondrial
type: Reaction
product: MODEL1310110025#
is: SBO:0000176
reversible: false

metaM spmd c
type: Species
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
name: Spermidine
initial amount: NaN
is: CHEBI:57834
has only substance units: false
is: C00315
is: SBO:0000247
constant: false
is: HMDB01257
boundary condition: false
initial concentration: 1.0

metaR ATPtm
is described by: ECO:0000269
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (291.1) or (293.1) or (292.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
product: MODEL1310110025#
modifier: MODEL1310110025#
reversible: false
kinetic law: MODEL1310110025#
type: Reaction
is: SBO:0000185
fast: false
name: ADP/ATP transporter, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110025#_ae0c8c5a_9d05_4bf0_bde8_acd983890030
type: Species
is: Q14916
name: SLC17A1
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6568
initial amount: NaN
constant: false

metaR ICDHy
is: SBO:0000176
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.42
notes: GENE_ASSOCIATION: (3417.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:10521434 NOTES:Two reactions (ICDH1 and ICDH2) for isocitrate dehydrogenase
name: isocitrate dehydrogenase (NADP)
reactant: MODEL1310110025#
type: Reaction
reversible: false
kinetic law: MODEL1310110025#
product: MODEL1310110025#
modifier: MODEL1310110025#

metaR r1591
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110025#
product: MODEL1310110025#

metaR PUNP3
reactant: MODEL1310110025#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.1
kinetic law: MODEL1310110025#
type: Reaction
product: MODEL1310110025#
modifier: MODEL1310110025#
name: purine-nucleoside phosphorylase (Guanosine)
is: SBO:0000176

metaM lnlccrn m
is: HMDB06469
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
name: Linoleyl carnitine
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false

metaR MCLACCYSR
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:6945862 NOTES:MM
kinetic law: MODEL1310110025#
fast: false
reactant: MODEL1310110025#
name: 3-mercaptolactate:cysteine reductase
is: SBO:0000176
product: MODEL1310110025#
type: Reaction

metaR EX Lcystin LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Cystine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_3b419d91_b0bf_478f_b5a0_c586ef0f7292
boundary condition: true
type: Species
constant: false
name: _AI191472_1_c
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AI191472
has only substance units: false
is: SBO:0000252

metaR r1851
reactant: MODEL1310110025#
is: SBO:0000185
name: Y+LAT2 Utilized transport
type: Reaction
reversible: false
product: MODEL1310110025#
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110025#
fast: false
is described by: ECO:0000000

metaR EX fe2 LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_fe2(u)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_77207a2c_b670_43f2_ac13_1b96fd6517c1
initial amount: NaN
is encoded by: hsa:BE966236
initial concentration: NaN
name: _BE966236_1_m
boundary condition: true
type: Species
constant: false
is: SBO:0000252
has only substance units: false

metaR MTHFD2
name: methylenetetrahydrofolate dehydrogenase (NAD)
fast: false
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/3.5.4.9
is: SBO:0000176
reactant: MODEL1310110025#
product: MODEL1310110025#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
modifier: MODEL1310110025#
is described by: ECO:0000134

metaM HC00342 m
constant: false
name: cis-aconitate(3-)
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
initial concentration: 1.0
has only substance units: false
is: CHEBI:16383
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false

metaM pi c
is: SBO:0000247
initial amount: NaN
is: HMDB00973
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:43474
constant: false
boundary condition: false
is: C00009
name: hydrogenphosphate
notes: FORMULA: HO4P CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110025#_2161e45f_b11a_44eb_88cd_87d87fbb4643
is: SBO:0000252
is encoded by: hsa:3038
initial concentration: NaN
is: O00219
boundary condition: true
has only substance units: false
name: HAS3
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_07e2170f_161e_4e40_b095_6ad789194033
type: Species
is: P00374
name: DHFR
is encoded by: hsa:1719
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR r1590
kinetic law: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110025#
fast: false
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110025#_f7888a05_2bf9_4e1b_9579_baf8afb0eabf
name: SLC46A1
has only substance units: false
is: Q96NT5
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:113235
boundary condition: true
type: Species

metaM thp2c c
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
constant: false
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB12130
name: 1-piperideine-6-carboxylate
initial amount: NaN
is: CHEBI:16987

metaR PUNP4
name: purine-nucleoside phosphorylase (Deoxyguanosine)
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.1
type: Reaction
reactant: MODEL1310110025#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110025#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
kinetic law: MODEL1310110025#
product: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_724a1283_7d0e_43af_8347_895e1009b64b
type: Species
name: CMPK1
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
is: B2R6S5
is: SBO:0000252
has only substance units: false
is encoded by: hsa:51727

metaR EX orot LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of orotate
type: Reaction

metaR ALASm
is version of: http://identifiers.org/ec-code/2.3.1.29
type: Reaction
name: 5-aminolevulinate synthase
is: SBO:0000176
product: MODEL1310110025#
reversible: false
reactant: MODEL1310110025#
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/2.3.1.37
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD

metaM ddcacoa m
is: SBO:0000247
is: CHEBI:57375
is: HMDB03571
type: Species
name: Dodecanoyl-CoA (n-C12:0CoA)
constant: false
initial amount: NaN
initial concentration: 1.0
is: C01832
boundary condition: false
has only substance units: false
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832

metaR r1384
name: Guanosine aminohydrolase EC:3.5.4.15
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
reactant: MODEL1310110025#
product: MODEL1310110025#
reversible: true

metaM 5forthf c
is: CHEBI:57456
constant: false
is: C00664
initial amount: NaN
is: HMDB01534
has only substance units: false
notes: FORMULA: C20H22N8O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00483 EHMN_ABBREVIATION: C00664
boundary condition: false
name: 5-Formiminotetrahydrofolate
initial concentration: 1.0
is: SBO:0000247
type: Species

metaM HC02149 c
constant: false
name: O-Propanoylcarnitine
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:28867
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1S/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
initial concentration: 1.0

metaR FRUt4
type: Reaction
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
name: D-fructose transport via sodium cotransport
product: MODEL1310110025#
is: SBO:0000185
reactant: MODEL1310110025#
fast: false
kinetic law: MODEL1310110025#

metaR UMPK5n
name: UMP kinase (dATP),nuclear
is: SBO:0000176
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
reactant: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_42b39a6e_0763_47ab_a698_1efd1e2dad38
has only substance units: false
name: PIGQ
constant: false
initial amount: NaN
is: B2RAU6
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:9091

metaM udpg r
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
type: Species
is: SBO:0000247
is: HMDB00286
initial amount: NaN
boundary condition: false
is: CHEBI:58367
constant: false

metaR GNDer
name: phosphogluconate dehydrogenase, endoplasmic reticulum
reversible: false
kinetic law: MODEL1310110025#
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000000
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.44 Confidence Level: 4 AUTHORS: PMID:2156506 NOTES:SMP Note no proton generation by the the reaction NCD
product: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_31bfc16d_b12a_404a_9cd1_2b2f5927e602
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AI631997
name: _AI631997_1_m
has only substance units: false
initial amount: NaN

metaR PUNP1
product: MODEL1310110025#
name: purine-nucleoside phosphorylase (Adenosine)
is: SBO:0000176
modifier: MODEL1310110025#
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.4.2.1
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
type: Reaction
fast: false
reversible: true
is described by: ECO:0000269

metaR sink 5hpet LPAREN c RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: sink reaction for 5(S)-HPETE(1-)
type: Reaction

metaR CYTK14n
fast: false
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reactant: MODEL1310110025#
modifier: MODEL1310110025#
reversible: true
name: cytidylate kinase (dCMP,CTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_358b96e0_bc0a_437e_9487_6acd2f28f010
type: Species
name: PDE4B
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:5142
is: Q5TEK5
initial concentration: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110025#_3f45eba7_1dd3_45a3_9fda_9853c2b4ae7a
initial concentration: NaN
is: Q9H490
is encoded by: hsa:128869
constant: false
boundary condition: true
name: PIGU
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110025#_9cc23d55_a4fa_4633_9cc3_b0f5ac710cdd
initial concentration: NaN
name: SLC25A4
has only substance units: false
initial amount: NaN
is: P12235
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:291
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_c5108f7e_805a_4f45_bc08_f12b44ad03d3
name: _AI345944_1_m
constant: false
is: SBO:0000252
is encoded by: hsa:AI345944
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_4e501f5a_c5f2_4381_a04f_5ce5d852b901
is: P21953
boundary condition: true
has only substance units: false
is encoded by: hsa:594
initial amount: NaN
name: BCKDHB
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN

metaM spc hs c
is: http://identifiers.org/pubchem.compound/5311445
initial amount: NaN
boundary condition: false
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
is: SBO:0000247
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
name: sphingosylphosphorylcholine

http://identifiers.org/biomodels.db/MODEL1310110025#_8e563d87_5507_43b1_80fd_e351736bde5b
is: Q05C14
is encoded by: hsa:2352
initial amount: NaN
initial concentration: NaN
name: FOLR3
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false

metaR EX spc hs LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: sphingosylphosphorylcholine (homo sapiens) exchange
type: Reaction

metaR r0074
type: Reaction
modifier: MODEL1310110025#
fast: false
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.1
is described by: ECO:0000000
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reactant: MODEL1310110025#
is: SBO:0000176

metaR r0464
type: Reaction
kinetic law: MODEL1310110025#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110025#
product: MODEL1310110025#
fast: false
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:

metaR DHORD9
reactant: MODEL1310110025#
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.3.5.2
notes: GENE_ASSOCIATION: (1723.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 1.3.3.1 Confidence Level: 4 AUTHORS: PMID:10727948,PMID:9693067 NOTES:_06-15-05 - EC 1.3.3.1 IT based on Bader et al, 1998, Prot. Expr. Purif,., 13,414-422 (I guess it is ubiquinone but i am not sure ) (needs FMN as cofactor) v(enzyme is located in inner-membrane of mitochondria, reaction take place in cytosol (Fig. 8 Rawls et al PMID: 10727948 )
kinetic law: MODEL1310110025#
name: dihydoorotic acid dehydrogenase (quinone10)
is described by: ECO:0000269
modifier: MODEL1310110025#
type: Reaction
fast: false
reversible: false
is: SBO:0000185

metaR r2334
product: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110025#
fast: false
reversible: true
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

http://identifiers.org/biomodels.db/MODEL1310110025#_fe3ec0db_0ac7_4805_8909_7e7e77da44e5
boundary condition: true
name: DGKA
initial amount: NaN
is encoded by: hsa:1606
is: SBO:0000252
is: P23743
type: Species
initial concentration: NaN
has only substance units: false
constant: false

metaR C226COAtx
kinetic law: MODEL1310110025#
type: Reaction
is: SBO:0000185
product: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is described by: ECO:0000000
reversible: true
fast: false
name: fatty acid intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110025#_5ace64cc_0ff6_4624_80a7_8fc20985bbfb
initial amount: NaN
name: ACO1
boundary condition: true
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:48
is: P21399
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_36f4c98c_1edb_4487_aa4f_1c3c0f3cf395
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
name: NDUFS1
is encoded by: hsa:4719
is: P28331
is: SBO:0000252
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_e46474ba_9cfc_4928_a74c_f2837573f61e
type: Species
boundary condition: true
name: SLC37A4
initial amount: NaN
is: A8K0S7
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2542
constant: false

metaR GTHPm
product: MODEL1310110025#
reversible: true
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.11.1.15
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
modifier: MODEL1310110025#
fast: false
kinetic law: MODEL1310110025#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.11.1.12
name: glutathione peroxidase, mitochondria

metaM HC01412 m
is: CHEBI:61405
initial amount: NaN
is: SBO:0000247
name: trans-tetradec-2-enoyl-CoA(4-)
constant: false
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110025#_b229443a_1f43_4aa4_9f0f_c98fcf8514cb
is: P10696
has only substance units: false
constant: false
is encoded by: hsa:251
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
name: ALPPL2
boundary condition: true

metaR r1639
product: MODEL1310110025#
kinetic law: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110025#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
modifier: MODEL1310110025#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110025#_8889d6dd_edc2_49b3_a61d_3d6a9b7d3b71
type: Species
is encoded by: hsa:84720
has only substance units: false
is: SBO:0000297
constant: false
name: PIGF:PIGO
has part: Q6IB04
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5281
boundary condition: true

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

metaR r1922
is: SBO:0000185
product: MODEL1310110025#
reversible: false
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110025#
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110025#_da4c4bf8_f06d_4da9_a309_cc457d39cb83
has only substance units: false
name: SLC16A2
is encoded by: hsa:6567
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
boundary condition: true
is: P36021
is: SBO:0000252

metaR 3SPYRSP
kinetic law: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM
reversible: false
fast: false
name: 3-sulfinopyruvate hydrolase (spotaneous reaction)
reactant: MODEL1310110025#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000

metaM methf m
name: (6R)-5,10-methenyltetrahydrofolate
is: HMDB01354
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:57455

metaM csn c
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
is: HMDB00630
name: cytosine
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
is: CHEBI:16040

http://identifiers.org/biomodels.db/MODEL1310110025#_25cafbf5_53e8_47d9_866e_29b2837a4209
constant: false
is encoded by: hsa:18
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: ABAT
type: Species

metaR r0999
name: Facilitated diffusion
is: SBO:0000185
reactant: MODEL1310110025#
type: Reaction
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
fast: false
reversible: true
product: MODEL1310110025#
is described by: ECO:0000000

metaM thr L c
initial amount: NaN
boundary condition: false
is: CHEBI:16857
initial concentration: 1.0
type: Species
name: L-threonine
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
is: HMDB00167
is: SBO:0000247
has only substance units: false
constant: false

metaR RE3347C
reversible: true
product: MODEL1310110025#
reactant: MODEL1310110025#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
kinetic law: MODEL1310110025#
name: RE3347
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110025#_acdfa369_8286_49f2_8f1f_e303b10ff0f6
is: SBO:0000252
is encoded by: hsa:3032
is: P55084
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
name: HADHB

metaR r1595
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110025#
is: SBO:0000185
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110025#
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true

metaM Rtotal2coa c
boundary condition: false
constant: false
initial amount: NaN
is: C00055
name: R total 2 coenzyme A
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB00095
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4
is: CHEBI:60377

metaM apoC Lys m
is: CHEBI:32551
type: Species
constant: false
boundary condition: false
name: Apocarboxylase (Lys residue)
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB00182
notes: FORMULA: C6H13N2OX CHARGE: 0
is: SBO:0000247

metaM gua c
initial concentration: 1.0
is: C00242
is: CHEBI:16235
boundary condition: false
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
is: HMDB00132
is: SBO:0000247
type: Species
constant: false
has only substance units: false
name: Guanine
initial amount: NaN

metaR Coqe
reactant: MODEL1310110025#
is: SBO:0000185
fast: false
product: MODEL1310110025#
reversible: true
name: Transport of q10
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110025#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110025#_53f46276_9721_4c42_8fb6_e64ec3ac07d1
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
is: Q5JRA6
is encoded by: hsa:375056
name: MIA3

metaR It
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
type: Reaction
reactant: MODEL1310110025#
name: Iodide uniport
is described by: ECO:0000269
kinetic law: MODEL1310110025#
reversible: true
fast: false
is: SBO:0000185
modifier: MODEL1310110025#
product: MODEL1310110025#

metaM lpro m
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: S2X CHARGE: 0 EHMN_ABBREVIATION: C02051
has only substance units: false
constant: false
boundary condition: false
name: Lipoylprotein
is: CHEBI:15804
initial concentration: 1.0

W3 CDTF: Fri Aug 31 00:59:06 BST 2012

metaR AHCYStd
fast: false
is described by: ECO:0000134
is: SBO:0000185
type: Reaction
product: MODEL1310110025#
reactant: MODEL1310110025#
reversible: true
kinetic law: MODEL1310110025#
name: diffusion of S-Adenosyl-L-homocysteine
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:

metaR r0998
kinetic law: MODEL1310110025#
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
name: Facilitated diffusion
is: SBO:0000185
reactant: MODEL1310110025#

metaR CO2t
reversible: true
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
reactant: MODEL1310110025#
name: CO2 transporter via diffusion
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110025#
is: SBO:0000185

metaR r0181
modifier: MODEL1310110025#
is: SBO:0000176
kinetic law: MODEL1310110025#
type: Reaction
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110025#
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false

metaR r1594
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR DM atp c
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
name: DM_atp(c)
fast: false
is: SBO:0000176
type: Reaction
reversible: false
product: MODEL1310110025#
kinetic law: MODEL1310110025#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110025#_fa6ac6d9_9651_4754_8b55_46c186e6774b
initial concentration: NaN
type: Species
is encoded by: hsa:6821
is: P51687
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
name: SUOX

metaM udp n
initial concentration: 1.0
is: CHEBI:58223
is: SBO:0000247
is: HMDB00295
constant: false
initial amount: NaN
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
boundary condition: false
has only substance units: false
type: Species
name: UDP(3-)

metaR r1637
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110025#
reversible: true
modifier: MODEL1310110025#
type: Reaction
kinetic law: MODEL1310110025#

metaR r1920
is described by: ECO:0000000
type: Reaction
reversible: false
kinetic law: MODEL1310110025#
product: MODEL1310110025#
is: SBO:0000185
modifier: MODEL1310110025#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110025#_5b741523_9631_451b_99be_ce828a693087
boundary condition: true
name: FOLR1
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2348
constant: false

metaM glu5sa m
initial amount: NaN
is: CHEBI:17232
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
constant: false
is: C01165
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB02104
is: SBO:0000247
name: L-Glutamate 5-semialdehyde
boundary condition: false

metaR CLS hs
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000176
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (54675.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10799718 NOTES:NJ
reversible: false
name: cardiolipin synthase (homo sapiens)

metaM 13dpg c
is: SBO:0000247
name: 3-Phospho-D-glyceroyl phosphate
initial concentration: 1.0
is: CHEBI:57604
constant: false
is: C00236
boundary condition: false
is: http://identifiers.org/pubchem.compound/3535
type: Species
has only substance units: false
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
initial amount: NaN
is: HMDB01270

metaR r0354
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
type: Reaction
product: MODEL1310110025#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110025#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110025#_4162c3e6_cb30_4042_a1a9_57da4f925620
initial amount: NaN
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
name: _728226_1_e
is encoded by: hsa:728226
boundary condition: true

metaR r2079
kinetic law: MODEL1310110025#
fast: false
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
product: MODEL1310110025#
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reactant: MODEL1310110025#
reversible: true

W3 CDTF: Fri Aug 31 00:59:06 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110025#_7e84d187_da3c_44a8_b6d6_1cbd4607e273
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
name: PECR
is: Q9BY49
initial amount: NaN
has only substance units: false
is encoded by: hsa:55825
boundary condition: true

metaR r1593
fast: false
type: Reaction
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110025#
is: SBO:0000185
kinetic law: MODEL1310110025#
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110025#_3de673c7_7489_4207_be4b_b0c69c904f4f
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:AI824319
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: _AI824319_1_r

http://identifiers.org/biomodels.db/MODEL1310110025#_ef808575_94ed_4a1f_86a4_602e6e78f556
initial concentration: NaN
is encoded by: hsa:8659
has only substance units: false
is: SBO:0000252
name: ALDH4A1
initial amount: NaN
is: P30038
constant: false
type: Species
boundary condition: true

metaR r1638
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110025#
fast: false
reversible: true
modifier: MODEL1310110025#
product: MODEL1310110025#
kinetic law: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110025#_5ed899f9_5c69_461e_a89c_ea30f709310b
is: Q96SL4
initial amount: NaN
has only substance units: false
is encoded by: hsa:2882
is: SBO:0000252
name: GPX7
type: Species
initial concentration: NaN
constant: false
boundary condition: true

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

metaM gua e
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
initial concentration: 1.0
is: HMDB00132
has only substance units: false
is: CHEBI:16235
initial amount: NaN
name: guanine
is: SBO:0000247
boundary condition: false
type: Species
constant: false

metaR r1921
fast: false
modifier: MODEL1310110025#
name: Y+LAT2 Utilized transport
reversible: false
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110025#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_2e973b53_ed18_41f6_8885_7ded8ec6ebb6
is encoded by: hsa:5281
boundary condition: true
initial amount: NaN
name: PIGF
is: SBO:0000252
has only substance units: false
constant: false
type: Species
is: Q6IB04
initial concentration: NaN

metaR r1592
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
reactant: MODEL1310110025#
is: SBO:0000185
product: MODEL1310110025#

metaR r0355
type: Reaction
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110025#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/4.2.1.3
product: MODEL1310110025#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110025#_1290cf10_f0c6_4795_b66e_9ca11332e9a4
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
name: DGKH
constant: false
is: A8K0I1
is encoded by: hsa:160851

http://identifiers.org/biomodels.db/MODEL1310110025#_60a980f8_029c_416e_a40c_07d83088a64c
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:84532
constant: false
name: ACSS1
type: Species
is: Q9NUB1
initial concentration: NaN
initial amount: NaN

metaR IPDPtx
type: Reaction
is: SBO:0000185
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 5.3.3.2 Confidence Level: 1 AUTHORS: PMID:11111079 NOTES:
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
reversible: true
fast: false
product: MODEL1310110025#
name: Isopentenyl diphosphate transport (peroxisome)

metaR EX lnlncg LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gamma-linolenic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_7554b001_822a_40c2_9e20_56a9de609575
type: Species
name: SLC26A6
is: SBO:0000252
initial amount: NaN
is: Q548A7
initial concentration: NaN
is encoded by: hsa:65010
constant: false
boundary condition: true
has only substance units: false

metaR SPC HSt
fast: false
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069827 NOTES:
name: sphingosylphosphorylcholine transport (diffusion)
reversible: true
product: MODEL1310110025#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

metaR DAG HSter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:
reactant: MODEL1310110025#
name: diacylglycerol ER export
kinetic law: MODEL1310110025#
reversible: false
fast: false
is described by: ECO:0000000
product: MODEL1310110025#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_ee4534ee_7019_46d7_bbf9_753a98273f59
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:211
boundary condition: true
initial amount: NaN
has only substance units: false
is: P13196
name: ALAS1

http://identifiers.org/biomodels.db/MODEL1310110025#_8aa4be8a_3c6b_4235_afdb_4b5b8fb042eb
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: Q9H3S5
name: PIGM
type: Species
is encoded by: hsa:93183
boundary condition: true

metaR THBPT4ACAMDASE
fast: false
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.2.1.96
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
is: SBO:0000176
reversible: false
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
type: Reaction
reactant: MODEL1310110025#

metaR EX xyl D LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Xylose exchange
type: Reaction

metaM forglu c
is: CHEBI:18327
constant: false
is: HMDB00854
is: SBO:0000247
notes: FORMULA: C6H8N2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00357 EHMN_ABBREVIATION: C00439
type: Species
initial amount: NaN
has only substance units: false
is: C00439
name: N-Formimidoyl-L-glutamate
initial concentration: 1.0
boundary condition: false

metaR NAt3 1
fast: false
name: sodium proton antiporter (H:NA is 1:1)
is: SBO:0000185
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (389015.1) or (6548.1) or (6550.1) or (6549.1) or (6553.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:7759094,PMID:8199403,PMID:8595899,PMID:9933641 NOTES:JLR
type: Reaction
reversible: true
product: MODEL1310110025#
kinetic law: MODEL1310110025#
is described by: ECO:0000269
reactant: MODEL1310110025#

metaR r1635
kinetic law: MODEL1310110025#
product: MODEL1310110025#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110025#
is: SBO:0000185
reversible: true
type: Reaction
modifier: MODEL1310110025#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110025#_9854359d_afdc_4cf0_8112_c311bbc644aa
has only substance units: false
is: Q9BV79
initial amount: NaN
is: SBO:0000252
name: MECR
is encoded by: hsa:51102
type: Species
initial concentration: NaN
constant: false
boundary condition: true

metaR 3HBCOAHLm
is described by: ECO:0000000
kinetic law: MODEL1310110025#
type: Reaction
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
product: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM
reactant: MODEL1310110025#
is: SBO:0000176
reversible: false

metaM 3mlda c
is: http://identifiers.org/pubchem.compound/8122
is: C05828
initial concentration: 1.0
type: Species
is: HMDB02820
boundary condition: false
notes: FORMULA: C6H7N2O2 CHARGE: -1 INCHI: InChI=1/C6H8N2O2/c1-8-3-5(7-4-8)2-6(9)10/h3-4H,2H2,1H3,(H,9,10) EHMN_ABBREVIATION: C05828
initial amount: NaN
name: 3-Methylimidazoleacetic acid
has only substance units: false
is: SBO:0000247
constant: false

metaM CE2421 m
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
is: HMDB02329
type: Species
has only substance units: false
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
is: CHEBI:30623
name: (3S)-3-hydroxylinoleoyl-CoA
is: SBO:0000247

metaM gtp m
is: CHEBI:37565
is: C00044
type: Species
initial amount: NaN
name: GTP
is: HMDB01273
initial concentration: 1.0
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_91be3d3b_06e8_4b22_a7e1_85f270a78034
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:79646
is: Q9H999
has only substance units: false
initial concentration: NaN
name: PANK3

metaR FOLt2le
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
name: folate transport via anion exchange
type: Reaction
reactant: MODEL1310110025#
product: MODEL1310110025#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110025#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110025#_5bb2b103_9a85_4567_8be3_b629d63e73bf
initial concentration: NaN
has only substance units: false
name: NOS3
is encoded by: hsa:4846
boundary condition: true
is: SBO:0000252
constant: false
is: A0S0A7
type: Species
initial amount: NaN

metaM HC01405 m
has only substance units: false
name: (S)-Hydroxyoctanoyl-CoA
is: CHEBI:28632
boundary condition: false
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_4c23b88c_e6c3_485e_8b42_e14fbd1b4fd8
is encoded by: hsa:3418
is: P48735
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
name: IDH2
type: Species
initial concentration: NaN
is: SBO:0000252

metaR r1599
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110025#
product: MODEL1310110025#
fast: false
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110025#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110025#_497256bc_7e03_4ded_92ad_3c9fc3a9b051
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5860
initial concentration: NaN
constant: false
has only substance units: false
is: P09417
name: QDPR
type: Species
boundary condition: true

metaR CYTK2n
reactant: MODEL1310110025#
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP),nuclear
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
product: MODEL1310110025#
reversible: true
fast: false
kinetic law: MODEL1310110025#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110025#_635d922b_dbbf_44b7_8678_73f52e0651b3
is encoded by: hsa:5136
initial concentration: NaN
is: P54750
has only substance units: false
name: PDE1A
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
boundary condition: true

metaM ha pre1 l
is: CHEBI:16126
type: Species
initial concentration: 1.0
name: hyaluronan biosynthesis, precursor 1
constant: false
initial amount: NaN
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR r0994
kinetic law: MODEL1310110025#
is described by: ECO:0000000
is: SBO:0000185
name: Facilitated diffusion
reversible: true
product: MODEL1310110025#
reactant: MODEL1310110025#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:

metaR FAOXC14C12x
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)x
type: Reaction

metaR EX 5mta LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-S-methyl-5-thioadenosine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_75d09da5_1d21_4312_9dd1_4a77705273a3
name: PIGW
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:284098
boundary condition: true
is: Q7Z7B1
constant: false
has only substance units: false
is: SBO:0000252

metaM gpi sig r
is: SBO:0000247
has only substance units: false
is: HMDB00224
initial amount: NaN
type: Species
is: CHEBI:58190
name: glycophosphatidylinositol (GPI) signal sequence (C-terminal peptide)
constant: false
notes: FORMULA: Y CHARGE: 0
boundary condition: false
initial concentration: 1.0

metaR D3AIBTm
reactant: MODEL1310110025#
reversible: true
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
product: MODEL1310110025#
is: SBO:0000176
kinetic law: MODEL1310110025#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
fast: false

metaR BACCL
reversible: false
is version of: http://identifiers.org/ec-code/6.3.4.10
name: biotin-[acetyl-CoA-carboxylase] ligase
kinetic law: MODEL1310110025#
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110025#
fast: false
modifier: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
product: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_76c6ad1e_a32b_4c70_971c_2ca008229311
initial amount: NaN
name: MTHFD1L
is encoded by: hsa:25902
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: B2RD24
has only substance units: false

metaR r1636
product: MODEL1310110025#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110025#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110025#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_f15de89c_a15e_49ca_ae79_1dc66cb12153
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5141
name: PDE4A
is: P27815
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
type: Species

metaR TDCHOLAte
is: SBO:0000185
product: MODEL1310110025#
name: bile acid intracellular transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000000
reversible: true
type: Reaction

metaR CHAT
reactant: MODEL1310110025#
reversible: true
product: MODEL1310110025#
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110025#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.6
modifier: MODEL1310110025#
name: Choline O-acetyltransferase
fast: false
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ

metaM c226coa m
has only substance units: false
initial concentration: 1.0
name: cervonyl coenzyme A
is: C16169
is: http://identifiers.org/pubchem.compound/47205479
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
boundary condition: false

metaM gmp e
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
type: Species
constant: false
has only substance units: false
is: CHEBI:58115
is: HMDB01397
name: GMP(3-)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110025#_42c8c4b6_7182_4c30_b502_08a95fb13249
is: SBO:0000252
name: LDHD
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
is: Q86WU2
initial concentration: NaN
is encoded by: hsa:197257

metaM gtp n
type: Species
boundary condition: false
initial amount: NaN
is: HMDB01273
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
name: GTP(4-)
has only substance units: false
is: SBO:0000247
is: CHEBI:37565
constant: false
initial concentration: 1.0

metaR ILEt5m
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
product: MODEL1310110025#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: Isoleucine mitochondrial transport

metaM tmndnccoa x
boundary condition: false
name: timnodonyl coenzyme A
is: HMDB06514
is: SBO:0000247
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN

metaM glcur e
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
is: HMDB00127
initial amount: NaN
name: D-glucuronate
is: CHEBI:15748
constant: false

metaR r1598
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110025#
reversible: true
reactant: MODEL1310110025#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110025#

metaR CTPtn
fast: false
reactant: MODEL1310110025#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: CTP diffusion in nucleus
kinetic law: MODEL1310110025#
reversible: true
product: MODEL1310110025#
type: Reaction

metaR TMDK1m
is: SBO:0000176
name: thymidine kinase (ATP:thymidine)
kinetic law: MODEL1310110025#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 4 AUTHORS: PMID:12535661,PMID:9342341 NOTES:TV
is version of: http://identifiers.org/ec-code/2.7.1.21
reversible: false
modifier: MODEL1310110025#
product: MODEL1310110025#

metaR ETHP
product: MODEL1310110025#
name: ethanolamine phosphate phosphatase
is: SBO:0000176
modifier: MODEL1310110025#
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/3.1.3.75
type: Reaction
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (162466.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:15175005 NOTES:no high energy phosphate compounds found associated w/ rxn NJ
fast: false
is described by: ECO:0000000
reversible: false

metaM 3mlda e
notes: FORMULA: C6H7N2O2 CHARGE: -1 INCHI: InChI=1/C6H8N2O2/c1-8-3-5(7-4-8)2-6(9)10/h3-4H,2H2,1H3,(H,9,10) EHMN_ABBREVIATION: C05828
boundary condition: false
is: HMDB02820
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
is: C05828
type: Species
name: 3-Methylimidazoleacetic acid
is: http://identifiers.org/pubchem.compound/8122

metaR r0993
product: MODEL1310110025#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.208.2
fast: false
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14716480,PMID:15209530,PMID:15297262 NOTES:
type: Reaction
is: SBO:0000185

metaM udp r
is: CHEBI:58223
is: C00015
initial amount: NaN
is: HMDB00295
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
name: UDP
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_97961bb8_1b4b_48c6_8751_0ac13fccf2a3
has only substance units: false
name: ALDH3A2
boundary condition: true
is encoded by: hsa:224
constant: false
is: SBO:0000252
initial concentration: NaN
is: P51648
initial amount: NaN
type: Species

metaM zymst r
is: SBO:0000247
is: HMDB06271
name: zymosterol
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:18252
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110025#_951c9093_39c6_475f_8039_2a96abb816e5
initial concentration: NaN
has only substance units: false
type: Species
name: SLC24A4
constant: false
is: SBO:0000252
is encoded by: hsa:123041
initial amount: NaN
boundary condition: true

metaR r1597
type: Reaction
is: SBO:0000185
product: MODEL1310110025#
reactant: MODEL1310110025#
fast: false
kinetic law: MODEL1310110025#
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110025#_38d99de3_c479_473b_b57f_819f449985cc
name: PPAP2A
initial concentration: NaN
is: G3XA95
is: SBO:0000252
is encoded by: hsa:8611
constant: false
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true

metaR r1633
kinetic law: MODEL1310110025#
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110025#
product: MODEL1310110025#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

metaM thr L e
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
constant: false
is: SBO:0000247
is: CHEBI:16857
has only substance units: false
initial concentration: 1.0
type: Species
name: L-threonine
is: HMDB00167
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110025#_dfb3f7a9_2652_4dea_a45d_d564964d1389
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:6578
is: SBO:0000252
is: Q92959
initial amount: NaN
has only substance units: false
constant: false
name: SLCO2A1

http://identifiers.org/biomodels.db/MODEL1310110025#_0dec27a1_4aeb_45b9_b8c8_00b70c0ef149
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
name: AKR1D1
initial concentration: NaN
is encoded by: hsa:6718
boundary condition: true
is: P51857

metaR DNDPt8m
name: dADP transport via dUDP antiport
product: MODEL1310110025#
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110025#
is described by: ECO:0000269
reactant: MODEL1310110025#
type: Reaction
modifier: MODEL1310110025#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110025#_98fe4975_78ac_4d15_b401_0a9d237d0fa5
initial amount: NaN
is encoded by: hsa:4695
name: NDUFA2
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is: O43678
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110025#_bf4d7864_1e84_400c_b469_20ac4d50a0a1
is: Q6AI14
is encoded by: hsa:389015
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
name: SLC9A4
constant: false
initial concentration: NaN

metaR r0186
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
product: MODEL1310110025#
modifier: MODEL1310110025#
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
fast: false
kinetic law: MODEL1310110025#
type: Reaction

metaM csn e
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
is: HMDB00630
name: cytosine
type: Species
is: CHEBI:16040

metaM vitd3 e
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
initial amount: NaN
is: CHEBI:28940
is: HMDB00876
type: Species
initial concentration: 1.0
name: calciol
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110025#_740f0509_a85d_45e4_b2b7_e4d8a3f29876
constant: false
initial concentration: NaN
is: O15244
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6582
type: Species
name: SLC22A2
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110025#_56b4f254_b785_4b6d_bcfa_a95c5afbc969
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:492
has only substance units: false
name: ATP2B3
is: SBO:0000252
constant: false
is: Q16720

http://identifiers.org/biomodels.db/MODEL1310110025#_e36cd379_bd01_4f8b_947d_a727d813498a
boundary condition: true
is encoded by: hsa:2222
initial amount: NaN
constant: false
is: P37268
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
name: FDFT1

metaM imp e
name: IMP(2-)
is: HMDB00175
notes: FORMULA: C10H11N4O8P CHARGE: -2 INCHI: InChI=1S/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:58053
boundary condition: false

metaR DSAT
fast: false
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ
name: dihydrosphingosine N-acyltransferase
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110025#
reactant: MODEL1310110025#
type: Reaction
reversible: false

metaR r1925
reversible: false
is: SBO:0000185
fast: false
product: MODEL1310110025#
is described by: ECO:0000000
kinetic law: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110025#
modifier: MODEL1310110025#
name: Y+LAT2 Utilized transport

metaM psyl e
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: psyllium
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:57449
type: Species
notes: FORMULA: C9642006H15428700O8667414 CHARGE: 0

metaM gmp c
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: C00144
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: CHEBI:58115
name: GMP
is: HMDB01397

metaR r1634
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110025#
is: SBO:0000185
kinetic law: MODEL1310110025#
fast: false
reversible: true
product: MODEL1310110025#

metaR r1596
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110025#
is described by: ECO:0000000
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110025#_1ba3800b_de28_4ca4_a11a_b8cbb5cedb4c
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
name: PCBD1
constant: false
is encoded by: hsa:5092
initial concentration: NaN
is: SBO:0000252

metaM glcur c
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
type: Species
name: D-glucuronate
initial concentration: 1.0
is: CHEBI:15748
constant: false
is: HMDB00127
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110025#_c0706aab_b3c3_4a57_91da_a1d963f80735
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is: Q96PE7
initial amount: NaN
constant: false
name: MCEE
is encoded by: hsa:84693

http://identifiers.org/biomodels.db/MODEL1310110025#_d936cdea_3897_4ad2_86a8_12b3535c3b10
constant: false
initial amount: NaN
is: SBO:0000252
is: P23786
has only substance units: false
initial concentration: NaN
name: CPT2
type: Species
is encoded by: hsa:1376
boundary condition: true

metaR DHFtm
product: MODEL1310110025#
name: dihydrofolate reversible mitochondrial transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false

metaR BAAT4x
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.3.1.65
modifier: MODEL1310110025#
name: bile acid Coenzyme A: amino acid N-acyltransferase
reactant: MODEL1310110025#
is described by: ECO:0000304
reversible: false
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 2 AUTHORS: NOTES:fourth version analog added in similarity to BAAT1x, BAAT2x NJ
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110025#
fast: false

metaM lnlccrn c
initial amount: NaN
has only substance units: false
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
is: HMDB06469
constant: false
name: Linoleyl carnitine
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false

metaM lthstrl r
is: CHEBI:17168
is: HMDB01170
initial concentration: 1.0
name: 5alpha-cholest-7-en-3beta-ol
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189

metaR NACHEX1ly
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reactant: MODEL1310110025#
is: SBO:0000176
reversible: false
fast: false
product: MODEL1310110025#
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR FUMSO3tm
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
fast: false
product: MODEL1310110025#
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
type: Reaction
name: Fumarate:sulfite antiport, mitochondrial
modifier: MODEL1310110025#
is: SBO:0000185
reversible: true

metaR EX csn LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cytosine exchange
type: Reaction

metaR r2086
modifier: MODEL1310110025#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110025#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110025#
product: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_8c4bc4b5_ef06_4b71_988a_2c81426da81a
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: CYP1A1
constant: false
is: A0N0X8
is encoded by: hsa:1543
boundary condition: true
type: Species
is: SBO:0000252

metaR r0560
kinetic law: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
fast: false
type: Reaction
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:

metaM pd3 c
constant: false
initial concentration: 1.0
name: Previtamin D3
boundary condition: false
type: Species
is: HMDB06500
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h10,12-13,19,21,24-26,28H,6-9,11,14-18H2,1-5H3/b13-12-/t21-,24+,25-,26?,27-/m1/s1
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaR BILIRUBt2
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
modifier: MODEL1310110025#
fast: false
kinetic law: MODEL1310110025#
name: bilirubin transport via bicarbonate countertransport
is described by: ECO:0000269
reversible: true
type: Reaction
reactant: MODEL1310110025#
is: SBO:0000185

metaM lac L e
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
is: CHEBI:16651
type: Species
initial amount: NaN
constant: false
is: HMDB00190
boundary condition: false
name: (S)-lactate

metaR r0789
is described by: ECO:0000000
is: SBO:0000176
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
kinetic law: MODEL1310110025#
type: Reaction
product: MODEL1310110025#
modifier: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
is version of: http://identifiers.org/ec-code/1.14.13.15
reversible: true
reactant: MODEL1310110025#

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

metaM orot e
constant: false
is: HMDB00226
is: CHEBI:30839
boundary condition: false
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
name: orotate
has only substance units: false

metaR CSNAT2x
fast: false
product: MODEL1310110025#
kinetic law: MODEL1310110025#
is described by: ECO:0000269
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (54677.1) or (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:15464416,PMID:7829107 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.137
modifier: MODEL1310110025#
type: Reaction
name: carnitine dimethyl nonanoyl transferase, revsible, peroxisomal
is version of: http://identifiers.org/ec-code/2.3.1.7
reactant: MODEL1310110025#

metaR BTNDm
is version of: http://identifiers.org/ec-code/3.5.1.12
reactant: MODEL1310110025#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
is: SBO:0000176
reversible: false
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:Also acts on biotin esters IT
fast: false
name: biotinidase (biotin), mitochondrial

metaM ocdcea e
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:0
is: HMDB00207
is: C00712
name: octadecenoate (n-C18:1)
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C18H33O2 CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110025#_a6ce5a94_b6c9_4602_952f_9d1cdca15fa2
initial concentration: NaN
boundary condition: true
name: NDUFAB1
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:4706
has only substance units: false
is: O14561

metaM thp2c x
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
constant: false
type: Species
boundary condition: false
is: HMDB12130
is: SBO:0000247
name: 1-piperideine-6-carboxylate
initial amount: NaN
is: CHEBI:16987

http://identifiers.org/biomodels.db/MODEL1310110025#_4cfc0373_1f8d_42c3_a35d_31e46089a0e2
constant: false
boundary condition: true
initial concentration: NaN
is: P24752
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:38
name: ACAT1
initial amount: NaN

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

metaM glu L c
has only substance units: false
boundary condition: false
constant: false
is: HMDB00148
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: L-glutamate(1-)
type: Species
is: CHEBI:29985

metaM ocdcea c
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C18H33O2 CHARGE: -1
is: SBO:0000247
is: CHEBI:0
is: C00712
is: HMDB00207
type: Species
name: octadecenoate (n-C18:1)

http://identifiers.org/biomodels.db/MODEL1310110025#_3726b352_7954_464e_b3c6_6f2916785006
is: Q8WWX8
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:115584
has only substance units: false
name: SLC5A11
boundary condition: true

metaR r2085
reactant: MODEL1310110025#
product: MODEL1310110025#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
kinetic law: MODEL1310110025#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110025#
fast: false
is: SBO:0000185

metaR DESAT22 1p
name: fatty acyl-CoA desaturase (n-C22:4CoA -> n-C22:5CoA)
kinetic law: MODEL1310110025#
is described by: ECO:0000000
reactant: MODEL1310110025#
fast: false
reversible: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110025#

metaM vitd3 c
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
is: HMDB00876
initial concentration: 1.0
boundary condition: false
name: calciol
type: Species
constant: false
initial amount: NaN
is: CHEBI:28940
is: SBO:0000247
has only substance units: false

metaR HACD1m
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110025#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110025#
modifier: MODEL1310110025#
is: SBO:0000176
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
product: MODEL1310110025#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological

metaM xan c
constant: false
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
has only substance units: false
is: CHEBI:17712
type: Species
name: Xanthine
boundary condition: false
is: HMDB00292
is: C00385
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaM apoC Lys c
boundary condition: false
type: Species
notes: FORMULA: C6H13N2OX CHARGE: 0
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
name: Apocarboxylase (Lys residue)
is: CHEBI:32551
is: HMDB00182
initial concentration: 1.0

metaM pail hs n
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol(1-)
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
is: CHEBI:57880
is: SBO:0000247
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_4c23f51e_86bd_4be8_8ebe_2ae80135ec78
boundary condition: true
name: COX8C
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is encoded by: hsa:341947
initial amount: NaN
is: SBO:0000252
is: Q7Z4L0

metaR r0788
modifier: MODEL1310110025#
type: Reaction
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
product: MODEL1310110025#
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
reversible: true
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.15
is: SBO:0000176

metaM for r
is: C00058
is: HMDB00142
has only substance units: false
initial amount: NaN
constant: false
name: Formate
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: CHEBI:15740
boundary condition: false

metaM adrnl c
is: HMDB00068
is: CHEBI:33568
notes: FORMULA: C9H14NO3 CHARGE: 1 INCHI: InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3 EHMN_ABBREVIATION: C00788
initial amount: NaN
boundary condition: false
name: Adrenaline
constant: false
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaM lnlccoa c
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
has only substance units: false
is: http://identifiers.org/pubchem.compound/5462164
is: HMDB01064
initial amount: NaN
constant: false
type: Species
name: linoleic coenzyme A
is: SBO:0000247

metaM 3dhguln c
name: 3-dehydro-L-gulonate
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-3,5,7-9,11H,1H2,(H,12,13)/p-1/t2-,3+,5-/m0/s1
is: HMDB06334
type: Species
is: CHEBI:57655
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false

metaR RE3624M
modifier: MODEL1310110025#
is: SBO:0000176
product: MODEL1310110025#
kinetic law: MODEL1310110025#
type: Reaction
name: RE3624
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
reactant: MODEL1310110025#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.3.6
reversible: false

metaR AGDC
reactant: MODEL1310110025#
reversible: false
product: MODEL1310110025#
is described by: ECO:0000254
modifier: MODEL1310110025#
name: N-acetylglucosamine-6-phosphate deacetylase
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/3.5.1.25
is: SBO:0000176
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (51005.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.5.1.25 Confidence Level: 2 AUTHORS: NOTES:acetylglucosamine phosphate deacetylase; acetylaminodeoxyglucosephosphate acetylhydrolase; 2-acetamido-2-deoxy-D-glucose-6-phosphate amidohydrolase

http://identifiers.org/biomodels.db/MODEL1310110025#_0bdd5bce_06ad_4168_90c5_9de3f3e9d225
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: Q92819
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:3037
name: HAS2
boundary condition: true

metaM c226coa x
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205479
is: C16169
initial amount: NaN
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
type: Species
constant: false
boundary condition: false
name: cervonyl coenzyme A
initial concentration: 1.0
has only substance units: false

metaR CYTDK2m
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
name: cytidine kinase (ATP), mitochondrial
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
is described by: ECO:0000000
reversible: false
product: MODEL1310110025#
is: SBO:0000176

metaR GK1
modifier: MODEL1310110025#
fast: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110025#
name: guanylate kinase (GMP:ATP)
product: MODEL1310110025#
kinetic law: MODEL1310110025#
is described by: ECO:0000269
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.8

http://identifiers.org/biomodels.db/MODEL1310110025#_fbc3cd44_bba5_4ed7_bedf_f439701c4cdd
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:2023
initial concentration: NaN
is: E2DRY6
name: ENO1
has only substance units: false
boundary condition: true

metaR r2084
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
modifier: MODEL1310110025#
reactant: MODEL1310110025#
product: MODEL1310110025#

metaR CHOLATEt2
reactant: MODEL1310110025#
modifier: MODEL1310110025#
fast: false
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: (6554.1) or (6555.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12851823,PMID:7592981,PMID:8132774,PMID:9109432 NOTES:electrogenic uptake NJ
is: SBO:0000185
name: cholate transport via sodium cotransport
product: MODEL1310110025#

metaR r0787
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000000
modifier: MODEL1310110025#
product: MODEL1310110025#
is: SBO:0000176
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
is version of: http://identifiers.org/ec-code/1.1.1.1
type: Reaction
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110025#_048a2c9b_1942_4ead_923f_b475b20aafe5
is encoded by: hsa:8526
is: A1L4Q0
type: Species
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: DGKE
has only substance units: false
initial concentration: NaN

metaM sql r
is: HMDB00256
is: SBO:0000247
constant: false
name: squalene
is: CHEBI:15440
initial amount: NaN
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false

metaM orot c
has only substance units: false
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
type: Species
is: SBO:0000247
is: C00295
is: HMDB00226
name: Orotate
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:30839
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_2db6cf04_9d4f_4b79_876a_af98a9286fe5
is: B2RDZ2
boundary condition: true
is: SBO:0000252
name: RFK
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:55312
type: Species
constant: false

metaR HISSNAT5tc
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR PROt2r
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
product: MODEL1310110025#
name: L-proline reversible transport via proton symport
modifier: MODEL1310110025#
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000304
type: Reaction
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#

metaM itp c
is: CHEBI:57614
constant: false
initial amount: NaN
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
name: ITP(3-)
is: SBO:0000247
is: HMDB00189
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false

metaM glu L e
is: HMDB00148
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
initial concentration: 1.0
type: Species
name: L-glutamate(1-)
is: CHEBI:29985
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_8b1ee459_4f8a_4974_bf04_b952a6827bba
constant: false
initial amount: NaN
is: P49189
is: SBO:0000252
type: Species
boundary condition: true
name: ALDH9A1
initial concentration: NaN
has only substance units: false
is encoded by: hsa:223

http://identifiers.org/biomodels.db/MODEL1310110025#_6bf456ba_d143_4e02_81c6_65300f322598
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:3034
boundary condition: true
name: HAL
is: B4E0V8
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_0fd2323c_fec7_4fc2_97e2_c1c2e7f69ade
type: Species
name: PPCS
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:79717
is: Q9HAB8
is: SBO:0000252

metaM estradiol r
name: estradiol
is: HMDB00151
constant: false
is: SBO:0000247
is: CHEBI:16469
boundary condition: false
initial amount: NaN
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
initial concentration: 1.0
type: Species
has only substance units: false

metaR r2083
is: SBO:0000185
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
product: MODEL1310110025#
fast: false
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110025#

metaR NACDe
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: release of nicotinate at the basolateral surface
type: Reaction

metaM L2aadp6sa c
is: SBO:0000247
constant: false
has only substance units: false
name: L-allysine
is: HMDB01263
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
initial concentration: 1.0
type: Species
is: CHEBI:17917

http://identifiers.org/biomodels.db/MODEL1310110025#_18755026_ad66_4a53_88be_1d253296474e
is: Q9NWU1
is encoded by: hsa:54995
name: OXSM
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN

metaM retinol 9 cis c
is: CHEBI:17336
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
is: HMDB06217
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
name: 9-cis-retinol
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_e41ebb3e_6dea_4ccf_a26e_61b1313d07ed
constant: false
is: Q96KH8
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: SLC6A2
boundary condition: true
is encoded by: hsa:6530

http://identifiers.org/biomodels.db/MODEL1310110025#_a44d35b4_fa56_4af4_8c51_43455337910d
has only substance units: false
name: ESPN
boundary condition: true
initial concentration: NaN
constant: false
is: B1AK53
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:83715

http://identifiers.org/biomodels.db/MODEL1310110025#_0312bd28_16f6_4b93_8f48_17cb28a113e9
is encoded by: hsa:441024
name: MTHFD2L
is: Q9H903
boundary condition: true
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR BTNPLm
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
reversible: false
modifier: MODEL1310110025#
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
is described by: ECO:0000000
type: Reaction
name: holocarboxylase synthestase (biotin protein ligase), mitochondrial
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/6.3.4.10

http://identifiers.org/biomodels.db/MODEL1310110025#_f031de87_79f4_4220_bbc6_13fc9306aef4
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: B3KVI7
type: Species
boundary condition: true
is encoded by: hsa:3712
is: SBO:0000252
name: IVD

metaM dcdp c
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB01245
initial concentration: 1.0
has only substance units: false
is: C00705
name: dCDP
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
constant: false
is: CHEBI:58593

http://identifiers.org/biomodels.db/MODEL1310110025#_3d1d48d1_3119_4225_8862_905ba3e564b6
name: _AA278423_1_m
is encoded by: hsa:AA278423
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN

metaR RE1521M
name: RE1521
reactant: MODEL1310110025#
is: SBO:0000176
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
modifier: MODEL1310110025#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000

metaR FAOXC226205m
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:_1 round of beta-oxidation, loses degree of desat, so no fad peroxisomal (very long chain FA) c22:6,n-3 -> c20:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
reversible: false

metaR PHYCBOXL
type: Reaction
reversible: false
fast: false
is described by: ECO:0000212
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
name: L-Phenylalanine carboxy-lyase
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 4.1.1.28 Confidence Level: 1 AUTHORS: NOTES:SAB
is version of: http://identifiers.org/ec-code/4.1.1.28
product: MODEL1310110025#
modifier: MODEL1310110025#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110025#_bd7de4eb_3351_4b93_8276_6b3afeb0ce01
boundary condition: true
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:217
initial amount: NaN
initial concentration: NaN
name: ALDH2
has only substance units: false
is: P05091

http://identifiers.org/biomodels.db/MODEL1310110025#_124c73b8_5310_4bfb_a043_54d67ec28791
type: Species
initial amount: NaN
initial concentration: NaN
name: PGK2
is: P07205
is encoded by: hsa:5232
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR BUTt2r
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
reversible: true
product: MODEL1310110025#
is described by: ECO:0000269
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
is: SBO:0000185
name: Butyrate transport via proton symport, reversible
fast: false
type: Reaction

metaR r2110
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000000
modifier: MODEL1310110025#
type: Reaction
product: MODEL1310110025#
fast: false

metaR r1052
reactant: MODEL1310110025#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
fast: false
product: MODEL1310110025#
kinetic law: MODEL1310110025#
reversible: false
is: SBO:0000185
name: Vesicular transport

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

metaM no e
is: CHEBI:16480
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
is: HMDB03378
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
type: Species
name: Nitric oxide
is: C00533
is: SBO:0000247
has only substance units: false

metaR D LACt2
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110025#
fast: false
type: Reaction
name: D-lactate transport via proton symport
modifier: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
is described by: ECO:0000269
reactant: MODEL1310110025#

metaR 7DHCHSTEROLtr
product: MODEL1310110025#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110025#
name: cholesterol precursor intracellular transport
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
fast: false
reversible: true

metaR r1789
type: Reaction
reversible: false
is: SBO:0000185
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110025#
fast: false
product: MODEL1310110025#
modifier: MODEL1310110025#
is described by: ECO:0000000
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR EX for LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Formate exchange
type: Reaction

metaR CHOLtn
is described by: ECO:0000000
kinetic law: MODEL1310110025#
type: Reaction
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
name: Choline transport, nuclear through pores
fast: false
product: MODEL1310110025#
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110025#_34b9df63_5dc8_43ce_b24b_d988a5669d11
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:9488
name: PIGB
is: Q92521
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_eddd1864_74f0_4166_984b_fafce6fe4043
initial amount: NaN
constant: false
name: SGPP1
has only substance units: false
is encoded by: hsa:81537
type: Species
initial concentration: NaN
is: SBO:0000252
is: Q9BX95
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110025#_bc3be205_f9e5_4385_bd5d_fe558ee0d810
constant: false
is encoded by: hsa:1103
is: SBO:0000252
type: Species
is: Q6LEN5
name: CHAT
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaM arachd c
boundary condition: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
type: Species
constant: false
initial amount: NaN
is: CHEBI:32395
initial concentration: 1.0
is: SBO:0000247
is: HMDB01043
name: arachidonate
has only substance units: false

metaM ca2 c
boundary condition: false
is: CHEBI:29108
is: HMDB00464
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: calcium(2+)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_26a87710_cb84_4cf2_bf6d_9f40e0e98317
is: SBO:0000252
constant: false
is encoded by: hsa:205
initial amount: NaN
is: P27144
type: Species
has only substance units: false
name: AK4
initial concentration: NaN
boundary condition: true

metaM acgam c
is: HMDB00215
initial concentration: 1.0
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: CHEBI:17411
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
name: N-acetyl-D-glucosamine
type: Species

metaM dmnoncoa x
name: 4,8 dimethylnonanoyl-CoA
constant: false
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB11604
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1

metaR r1051
name: Vesicular transport
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
reactant: MODEL1310110025#
product: MODEL1310110025#
kinetic law: MODEL1310110025#
reversible: true
fast: false

metaR r2089
modifier: MODEL1310110025#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
product: MODEL1310110025#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR FE3R2e
reversible: false
notes: GENE_ASSOCIATION: (79901.1) SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11230685,PMID:12755454 NOTES:stoichiometry unknown; inferred from EC1.16.1.7 NCD
fast: false
product: MODEL1310110025#
name: Fe(III) reduction (ascorbate)
is: SBO:0000176
reactant: MODEL1310110025#
modifier: MODEL1310110025#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110025#

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

metaR r2111
product: MODEL1310110025#
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
reversible: true

metaM 2mpdhl m
has only substance units: false
name: S-(2-Methylpropanoyl)-dihydrolipoamide
constant: false
notes: FORMULA: C12H23NO2S2 CHARGE: 0 INCHI: InChI=1S/C12H23NO2S2/c1-9(2)12(15)17-8-7-10(16)5-3-4-6-11(13)14/h9-10,16H,3-8H2,1-2H3,(H2,13,14) EHMN_ABBREVIATION: C04424
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:17577
type: Species
initial concentration: 1.0

metaM HC02217 c
is: CHEBI:27647
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
initial concentration: 1.0
name: prostaglandin-g2
has only substance units: false

metaM itp e
boundary condition: false
has only substance units: false
initial amount: NaN
name: ITP(3-)
type: Species
is: SBO:0000247
is: HMDB00189
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
initial concentration: 1.0
constant: false
is: CHEBI:57614

metaM adp c
name: ADP
is: CHEBI:16761
has only substance units: false
is: HMDB01341
initial concentration: 1.0
is: C00008
is: http://identifiers.org/pubchem.compound/3310
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110025#_e6f40b45_1f61_4a7c_b81a_4c66730cfd86
constant: false
is encoded by: hsa:56606
initial amount: NaN
name: SLC2A9
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN

metaM idour l
type: Species
boundary condition: false
name: L-iduronate
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
initial amount: NaN
is: CHEBI:21338
constant: false
is: HMDB02704

metaM lnlncg c
has only substance units: false
name: gamma-linolenate
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:32391
is: HMDB03073
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110025#_ce2636b2_cd34_4b9a_8637_88157770e539
boundary condition: true
name: ACSL6
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: B2RB13
is encoded by: hsa:23305
initial amount: NaN
type: Species

metaR r0191
is: SBO:0000176
product: MODEL1310110025#
modifier: MODEL1310110025#
type: Reaction
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.2.1.24
notes: GENE_ASSOCIATION: (7915.1) or (9856.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275,PMID:4276999 NOTES:
fast: false
kinetic law: MODEL1310110025#
name: UTP:D-fructose-6-phosphate 1-phosphotransferase EC:2.7.1.11

metaM mgacpail hs r
constant: false
is: HMDB00220
initial amount: NaN
is: C00249
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: mannosyl-glucosaminyl-acylphosphatidylinositiol (H2)
notes: FORMULA: C37H68NO19PFULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:7896
type: Species
boundary condition: false

metaR r2088
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
kinetic law: MODEL1310110025#
is: SBO:0000185
modifier: MODEL1310110025#
is described by: ECO:0000000
reactant: MODEL1310110025#
product: MODEL1310110025#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110025#_54397081_0d45_47d0_9b56_d9216502c649
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: Q6IBC4
name: NDUFS6
initial concentration: NaN
is encoded by: hsa:4726

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

metaM sphs1p r
has only substance units: false
type: Species
is: SBO:0000247
constant: false
name: sphingosine 1-phosphate(1-)
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
is: CHEBI:60119
is: HMDB00277

metaR THRGLNexR
kinetic law: MODEL1310110025#
fast: false
is described by: ECO:0000304
modifier: MODEL1310110025#
type: Reaction
reversible: true
reactant: MODEL1310110025#
is: SBO:0000185
product: MODEL1310110025#
name: L-threonine/glycine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110025#_8447bfac_9ecd_44d8_b03a_7f334ae7e48d
type: Species
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
is: P24311
initial amount: NaN
name: COX7B
is encoded by: hsa:1349

metaM no c
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:16480
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
initial amount: NaN
type: Species
constant: false
is: HMDB03378
name: Nitric oxide
has only substance units: false
is: C00533

http://identifiers.org/biomodels.db/MODEL1310110025#_870a06c7_fd41_42c1_9ca7_5182ca563c46
name: ATP2B2
is: SBO:0000252
is encoded by: hsa:491
constant: false
is: Q4J699
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species

metaR DNDPt33m
is described by: ECO:0000269
kinetic law: MODEL1310110025#
reversible: false
name: dGDP transport via dUDP antiport
is: SBO:0000185
reactant: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110025#
modifier: MODEL1310110025#
fast: false

metaR r0706
fast: false
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.3.99.10
is described by: ECO:0000000
reactant: MODEL1310110025#
type: Reaction
modifier: MODEL1310110025#
is: SBO:0000176
product: MODEL1310110025#
reversible: false
notes: GENE_ASSOCIATION: (34.1) or (3712.1) or (R14373.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356170,PMID:8943006 NOTES:RE1814X
is version of: http://identifiers.org/ec-code/1.3.99.3
name: acyl-Coenzyme A dehydrogenase family, member 9 Bile acid biosynthesis EC:1.3.3.6

metaR r0679
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
type: Reaction
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110025#
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
kinetic law: MODEL1310110025#

metaM lac L c
is: CHEBI:16651
has only substance units: false
type: Species
constant: false
name: (S)-lactate
is: SBO:0000247
initial amount: NaN
is: HMDB00190
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
initial concentration: 1.0
boundary condition: false

metaM 11 cis retfa e
is: HMDB00972
boundary condition: false
initial amount: NaN
name: fatty acid 11-cis-retinol
has only substance units: false
is: CHEBI:57454
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0

metaM ca2 e
is: SBO:0000247
is: HMDB00464
is: CHEBI:29108
type: Species
has only substance units: false
name: calcium(2+)
initial amount: NaN
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
initial concentration: 1.0
constant: false
boundary condition: false

metaR FMNALKPle
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
reactant: MODEL1310110025#
product: MODEL1310110025#
kinetic law: MODEL1310110025#
reversible: false
is described by: ECO:0000134
type: Reaction
name: FMNALKPle

http://identifiers.org/biomodels.db/MODEL1310110025#_5d24c2a8_1623_40e1_b75e_fcae0e700f45
is encoded by: hsa:10873
initial concentration: NaN
type: Species
is: Q6TCH8
name: ME3
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false

metaR r2087
reactant: MODEL1310110025#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reversible: true
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is: SBO:0000185

metaM 1pyr5c m
boundary condition: false
is: CHEBI:15893
is: C03912
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB01301
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
name: 1-Pyrroline-5-carboxylate

metaM 4ppcys m
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:59458
constant: false
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
is: HMDB01117

metaR r0989
is described by: ECO:0000000
product: MODEL1310110025#
name: Postulated transport reaction
type: Reaction
reactant: MODEL1310110025#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110025#_bb9f9442_200f_445f_843b_203c89c65668
name: NDUFA11
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is encoded by: hsa:126328
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: C9JT23

http://identifiers.org/biomodels.db/MODEL1310110025#_4a46f0cf_7016_4c18_b0fd_13ca21bb2429
is: SBO:0000252
boundary condition: true
is: Q9H999
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:79646
name: PANK3
has only substance units: false

metaM cholcoads x
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA
initial concentration: 1.0
boundary condition: false
is: HMDB06889
has only substance units: false
notes: FORMULA: C48H74N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h9,23-25,27-34,36,38-40,44,56-58,60-61H,7-8,10-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01466 EHMN_ABBREVIATION: C05460
constant: false
type: Species
is: CHEBI:27505
is: SBO:0000247
initial amount: NaN

metaM lnlncg e
is: CHEBI:32391
initial concentration: 1.0
initial amount: NaN
name: gamma-linolenate
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
boundary condition: false
constant: false
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB03073

metaM msa m
initial amount: NaN
name: 3-oxopropanoate
boundary condition: false
constant: false
is: HMDB11111
initial concentration: 1.0
has only substance units: false
is: CHEBI:33190
is: SBO:0000247
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
type: Species

metaR r1629
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110025#
type: Reaction
is described by: ECO:0000000

metaR r0812
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110025#
modifier: MODEL1310110025#
type: Reaction
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.41
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false

metaM 3hpcoa m
initial amount: NaN
has only substance units: false
is: HMDB06807
name: 3-hydroxypropanoyl-CoA(4-)
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
initial concentration: 1.0
is: CHEBI:58528
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_d284c8ad_9d74_4ff4_bfbd_9cd93d9adf3e
name: COASY
boundary condition: true
initial concentration: NaN
is encoded by: hsa:80347
is: Q13057
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252

metaR r0817
kinetic law: MODEL1310110025#
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110025#
product: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
is version of: http://identifiers.org/ec-code/2.3.1.41
is version of: http://identifiers.org/ec-code/2.3.1.85

metaM cysam c
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: cysteaminium
type: Species
constant: false
is: HMDB02991
has only substance units: false
is: CHEBI:58029
initial concentration: 1.0

metaR BTNDe
is described by: ECO:0000269
product: MODEL1310110025#
type: Reaction
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7509806,PMID:8001986 NOTES:Also acts on biotin esters IT
is version of: http://identifiers.org/ec-code/3.5.1.12
kinetic law: MODEL1310110025#
name: biotinidase (biotin), extracellular
is: SBO:0000176
reversible: false
modifier: MODEL1310110025#
fast: false

metaM asn L e
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
is: HMDB00168
name: L-asparagine
is: CHEBI:17196
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110025#_cf26f49c_4790_48bb_adfa_c4d9507ce0ea
is: SBO:0000252
boundary condition: true
is encoded by: hsa:NOS2A
type: Species
initial amount: NaN
constant: false
has only substance units: false
name: _NOS2A_1_e
initial concentration: NaN

metaR AKR1D2
kinetic law: MODEL1310110025#
fast: false
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
reversible: false
is version of: http://identifiers.org/ec-code/1.3.1.3
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
modifier: MODEL1310110025#
product: MODEL1310110025#
reactant: MODEL1310110025#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_3d55aa31_a011_441b_99fb_9bba4b79363d
initial amount: NaN
constant: false
is encoded by: hsa:AA576959
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
name: _AA576959_1_c
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110025#_2157c55f_e892_4cea_9099_ccfa1434bb33
name: AMT
is encoded by: hsa:275
constant: false
boundary condition: true
is: P48728
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species

metaR r2114
kinetic law: MODEL1310110025#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110025#
reversible: true

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

metaR r2199
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
modifier: MODEL1310110025#

metaM xylu L c
has only substance units: false
boundary condition: false
is: HMDB00751
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
initial concentration: 1.0
name: L-xylulose
is: SBO:0000247
is: CHEBI:17399

metaR r0781
reactant: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.13.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
modifier: MODEL1310110025#
name: Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) Biosynthesis of steroids EC:1.14.13.70
fast: false
kinetic law: MODEL1310110025#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35

http://identifiers.org/biomodels.db/MODEL1310110025#_ee9d225a_76e1_4a1d_a336_80a3c349c01d
constant: false
boundary condition: true
is: P53602
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
name: MVD
initial concentration: NaN
is encoded by: hsa:4597

metaR PUNP7
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
reversible: true
name: purine-nucleoside phosphorylase (Xanthosine)
kinetic law: MODEL1310110025#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.1
fast: false
reactant: MODEL1310110025#
is: SBO:0000176
modifier: MODEL1310110025#

metaM spc hs e
initial concentration: 1.0
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: sphingosylphosphorylcholine
constant: false
is: http://identifiers.org/pubchem.compound/5311445
boundary condition: false

metaR 41R2A1H12BOOX
kinetic law: MODEL1310110025#
name: 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing)
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.4.3.4
reversible: false
fast: false
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110025#
reactant: MODEL1310110025#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110025#_5eebe3b7_00e1_4923_902e_73ebc1b8eef3
name: COX5A
constant: false
initial concentration: NaN
is: P20674
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:9377

metaM udpg c
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: C00029
is: HMDB00286
name: UDPglucose
type: Species
is: CHEBI:58367
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029

metaR CYOR u10m
is described by: ECO:0000134
kinetic law: MODEL1310110025#
reversible: false
is version of: http://identifiers.org/ec-code/3.5.1.92
modifier: MODEL1310110025#
is: SBO:0000185
name: ubiquinol-6 cytochrome c reductase, Complex III
reactant: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
product: MODEL1310110025#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3

metaR r0818
reactant: MODEL1310110025#
product: MODEL1310110025#
type: Reaction
kinetic law: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12657464,PMID:14519855,PMID:16194150 NOTES:
name: Transport reaction
is described by: ECO:0000000
reversible: false
is: SBO:0000185

metaM HC02202 c
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
is: CHEBI:57398
has only substance units: false
name: prostaglandin A1(1-)
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_88072748_7d01_4b07_b171_94b5cfa2e4b0
type: Species
is encoded by: hsa:100128062
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: _100128062_1_m
is: SBO:0000252
has only substance units: false
constant: false

metaR r2115
is described by: ECO:0000000
kinetic law: MODEL1310110025#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110025#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
product: MODEL1310110025#
reactant: MODEL1310110025#

metaR CYSTSERex
is: SBO:0000185
product: MODEL1310110025#
is described by: ECO:0000269
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (6519.1 and 11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: NOTES:SAB see PMID 14770310
modifier: MODEL1310110025#
name: L-cystine/glycine exchanger (cystine in)

metaR r2198
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
is described by: ECO:0000000
reversible: true
type: Reaction
reactant: MODEL1310110025#
product: MODEL1310110025#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
fast: false

metaR 4ABUTtcn
reversible: false
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: Jane D. Carver, W. Allan Walkera , The Journal of Nutritional Biochemistry, Volume 6, Issue 2, February 1995, Pages 58?72. NOTES:added during gap-filling, required for GABA role in cell proliferation.
is described by: ECO:0000134
product: MODEL1310110025#
name: transport of GABA
fast: false

http://identifiers.org/biomodels.db/MODEL1310110025#_845ec3fc_6fd9_4a44_8779_62c5d4d6cab7
initial concentration: NaN
initial amount: NaN
is: P46721
constant: false
is encoded by: hsa:6579
is: SBO:0000252
type: Species
name: SLCO1A2
boundary condition: true
has only substance units: false

metaM nac c
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:0
name: Nicotinate
has only substance units: false
notes: FORMULA: C6H4NO2 CHARGE: -1
initial amount: NaN
is: C00253
is: HMDB01488
constant: false
type: Species

metaR ACETONEt2m
reactant: MODEL1310110025#
type: Reaction
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110025#
name: acetone mitochondrial transport via proton symport
modifier: MODEL1310110025#
reversible: true
is described by: ECO:0000000
fast: false

metaM HC02149 m
has only substance units: false
initial amount: NaN
is: CHEBI:28867
name: O-Propanoylcarnitine
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1S/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
is: SBO:0000247
constant: false
type: Species
boundary condition: false
initial concentration: 1.0

metaR r0780
modifier: MODEL1310110025#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110025#
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
type: Reaction
kinetic law: MODEL1310110025#
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
fast: false
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:

metaR CSAPASEly
fast: false
is: SBO:0000176
reactant: MODEL1310110025#
product: MODEL1310110025#
name: chondroitin sulfate A proteoglycan protease, lysosome (endosome)
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
kinetic law: MODEL1310110025#
is described by: ECO:0000000

metaM HC01408 m
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:27648
name: 3-Oxohexanoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110025#_9bd140e4_83e1_4139_a19f_7ee4b9cfab7a
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:5281
boundary condition: true
is: Q07326
has only substance units: false
name: PIGF

metaR CHOLK
reversible: false
notes: GENE_ASSOCIATION: (1120.2) or (1119.1) or (1120.1) or (1119.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: Choline kinase
reactant: MODEL1310110025#
product: MODEL1310110025#
kinetic law: MODEL1310110025#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.32
type: Reaction
modifier: MODEL1310110025#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110025#_1a8e6bc3_6fa6_48bd_97f1_144a284c1241
is encoded by: hsa:55
is: P15309
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
name: ACPP
is: SBO:0000252
boundary condition: true

metaM retinal cis 9 c
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
is: HMDB01358
initial concentration: 1.0
type: Species
is: CHEBI:17898
is: SBO:0000247
name: all-trans-retinal
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575

metaR EX ahcys LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of S-adenosyl-L-homocysteine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_09078424_a1d3_4046_b0fb_811001161d01
constant: false
boundary condition: true
is encoded by: hsa:6571
name: SLC18A2
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
is: Q05940

metaM asn L c
has only substance units: false
is: CHEBI:17196
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
name: L-asparagine
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB00168

http://identifiers.org/biomodels.db/MODEL1310110025#_b7b45b65_1c71_4673_95a3_b3d86538504a
type: Species
boundary condition: true
name: PRODH
is: O43272
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:5625
is: SBO:0000252
initial amount: NaN

metaR r2338
reversible: true
fast: false
reactant: MODEL1310110025#
product: MODEL1310110025#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110025#
name: Major Facilitator(MFS) TCDB:2.A.1.19.1

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

metaR r2112
modifier: MODEL1310110025#
reversible: true
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110025#
is described by: ECO:0000000
product: MODEL1310110025#
type: Reaction
kinetic law: MODEL1310110025#
fast: false

metaR RE3524R
reversible: true
product: MODEL1310110025#
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
name: RE3524
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
is described by: ECO:0000000

metaM dcamp c
is: CHEBI:57567
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
is: C03794
type: Species
initial amount: NaN
name: N6-(1,2-Dicarboxyethyl)-AMP
is: HMDB00536

metaM xol25oh r
is: SBO:0000247
is: CHEBI:42977
name: 25-hydroxycholesterol
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB06247
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01146
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_2dc0deed_bc91_4183_a63c_fbda6bd41256
initial concentration: NaN
has only substance units: false
boundary condition: true
is: Q92523
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
name: CPT1B
is encoded by: hsa:1375

http://identifiers.org/biomodels.db/MODEL1310110025#_1629d4f7_48f4_4d6e_88bd_d3553f4bc503
is encoded by: hsa:51557
name: LGSN
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
is: Q5TDP6
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_5c24a3c9_5faa_46f9_980d_e333f2d7a0bc
has only substance units: false
initial amount: NaN
is: Q99884
name: SLC6A7
initial concentration: NaN
type: Species
is encoded by: hsa:6534
is: SBO:0000252
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110025#_f470840a_16a3_467f_82d6_b690500b17ff
initial amount: NaN
is: P60891
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5631
name: PRPS1
is: SBO:0000252
type: Species

metaR ILEtec
is described by: ECO:0000269
product: MODEL1310110025#
kinetic law: MODEL1310110025#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
reactant: MODEL1310110025#
name: L-isoleucine transport via diffusion (extracellular to cytosol)
type: Reaction
fast: false
reversible: true
modifier: MODEL1310110025#

metaR r2197
reactant: MODEL1310110025#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110025#
type: Reaction
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110025#
reversible: true
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaR r1448
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
reactant: MODEL1310110025#
name: EC:1.3.3.6
reversible: false
product: MODEL1310110025#
type: Reaction
kinetic law: MODEL1310110025#
is: SBO:0000176
fast: false

metaR r0899
reactant: MODEL1310110025#
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
name: Amino acid transporter ATB0+ Facilitated diffusion
kinetic law: MODEL1310110025#
reversible: true
is described by: ECO:0000000

metaR DRPA
kinetic law: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110025#
is: SBO:0000176
fast: false
name: deoxyribose-phosphate aldolase
type: Reaction

metaR PUNP5
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110025#
name: purine-nucleoside phosphorylase (Inosine)
fast: false
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.4.2.1
product: MODEL1310110025#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
kinetic law: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_5a553904_cfca_4e6d_9e99_94a27650e4eb
constant: false
is encoded by: hsa:3251
has only substance units: false
is: SBO:0000252
name: HPRT1
type: Species
is: P00492
initial amount: NaN
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_01859dfd_8069_44b1_beef_2568e692b26b
boundary condition: true
is encoded by: hsa:277
initial concentration: NaN
name: AMY1B
is: P04745
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110025#_f6952d2b_b9a7_4558_bfe7_49f607241574
initial concentration: NaN
name: PDE7B
is encoded by: hsa:27115
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is: Q9NP56

http://identifiers.org/biomodels.db/MODEL1310110025#_f77ab02d_0038_4146_bd59_089771de5e04
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: ALDOA
is encoded by: hsa:226
boundary condition: true
is: P04075
constant: false
type: Species
has only substance units: false

metaR EX fmn LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for FMN
type: Reaction

metaR r2113
product: MODEL1310110025#
kinetic law: MODEL1310110025#
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
modifier: MODEL1310110025#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110025#
reversible: true

metaR MTHFCm
type: Reaction
is described by: ECO:0000269
product: MODEL1310110025#
kinetic law: MODEL1310110025#
reversible: true
reactant: MODEL1310110025#
fast: false
is version of: http://identifiers.org/ec-code/6.3.4.3
is version of: http://identifiers.org/ec-code/3.5.4.9
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
name: methenyltetrahydrifikate cyclohydrolase, mitochondrial
is: SBO:0000176
modifier: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_c5e593f2_3977_4048_a14e_421b0c97b2f6
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:54511
type: Species
constant: false
name: HMGCLL1
has only substance units: false
is: Q9NT06
initial amount: NaN
boundary condition: true

metaR EX gtp LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GTP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_4fe51a58_377d_4430_ba6d_2e1aad660507
has only substance units: false
constant: false
is encoded by: hsa:641649
is: SBO:0000252
type: Species
boundary condition: true
is: C9JZ62
initial concentration: NaN
initial amount: NaN
name: TMEM91

metaM HC02217 e
type: Species
name: prostaglandin-g2
is: SBO:0000247
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:27647
constant: false
initial concentration: 1.0

metaM nac e
has only substance units: false
initial concentration: 1.0
is: CHEBI:0
type: Species
is: HMDB01488
constant: false
initial amount: NaN
is: SBO:0000247
is: C00253
notes: FORMULA: C6H4NO2 CHARGE: -1
boundary condition: false
name: Nicotinate

metaR SERt4
modifier: MODEL1310110025#
fast: false
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:JLR
product: MODEL1310110025#
reversible: false
name: L-serine via sodium symport
is described by: ECO:0000269

metaR r0081
name: L-Alanine:2-oxoglutarate aminotransferase Glutamate metabolism / Alanine and aspartate metabolism EC:2.6.1.2
is version of: http://identifiers.org/ec-code/1.5.1.12
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Citric acid cycle EC Number: 2.6.1.2 Confidence Level: 0 AUTHORS: PMID:15663181,PMID:2088925,PMID:454616 NOTES:
reversible: true
product: MODEL1310110025#
is: SBO:0000176
modifier: MODEL1310110025#
type: Reaction
reactant: MODEL1310110025#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110025#

metaR r2196
product: MODEL1310110025#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110025#
reversible: true
reactant: MODEL1310110025#
is: SBO:0000185
kinetic law: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_b0263493_6131_46ec_9a6d_ec615b286cbd
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:2348
name: FOLR1
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110025#_0eb76a8e_acbd_4fa9_804f_f6780619d910
name: HADHA:HADHB
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3032
is: SBO:0000297
type: Species
is encoded by: hsa:3030
initial amount: NaN
constant: false
boundary condition: true
has part: E9KL44
has part: P55084

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaR r2118
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110025#
modifier: MODEL1310110025#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM 5fthf m
initial amount: NaN
name: 5-formyltetrahydrofolate(2-)
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB01562
is: CHEBI:57457
initial concentration: 1.0
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
type: Species

metaR r2437
kinetic law: MODEL1310110025#
type: Reaction
product: MODEL1310110025#
reactant: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is described by: ECO:0000000
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
is: SBO:0000185

metaM oaa m
is: C00036
constant: false
is: SBO:0000247
type: Species
name: Oxaloacetate
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:16452
initial concentration: 1.0
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
is: HMDB00223

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

metaR THRPHELAT2tc
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Threonine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_7e7d40cb_1eab_42a5_a38a_a57efea3ae39
name: ACOT4
initial concentration: NaN
is encoded by: hsa:122970
is: SBO:0000252
is: Q8N9L9
constant: false
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true

metaR r2195
product: MODEL1310110025#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110025#
reversible: true
modifier: MODEL1310110025#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110025#

metaR EX C02528 LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chenodeoxycholate exchange
type: Reaction

metaM idour e
initial amount: NaN
name: L-iduronate
has only substance units: false
is: CHEBI:21338
constant: false
type: Species
is: HMDB02704
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
boundary condition: false

metaR r2082
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110025#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110025#
type: Reaction
reactant: MODEL1310110025#
modifier: MODEL1310110025#
reversible: true

metaM estradiol e
is: SBO:0000247
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
name: estradiol
boundary condition: false
type: Species
is: HMDB00151
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16469

metaM dcdp m
constant: false
initial amount: NaN
name: dCDP(3-)
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: CHEBI:58593
has only substance units: false
is: SBO:0000247
is: HMDB01245
type: Species
initial concentration: 1.0
boundary condition: false

metaR CHOLtu
type: Reaction
modifier: MODEL1310110025#
product: MODEL1310110025#
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000269
is: SBO:0000185
name: Choline uniport
fast: false
reversible: true
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev

metaM leuktrB4 c
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
name: leukotriene B4(1-)
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
has only substance units: false
is: HMDB01085
type: Species
is: CHEBI:57461
initial amount: NaN

metaR r2119
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reactant: MODEL1310110025#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reversible: true

metaM cys L e
name: L-cysteine
constant: false
is: CHEBI:17561
is: SBO:0000247
type: Species
is: HMDB00574
initial amount: NaN
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
boundary condition: false
has only substance units: false
initial concentration: 1.0

MODEL1310110025
reaction: metaR GLYSNAT5tc
reaction: metaR Htg
species: metaM vitd3 c
reaction: metaR GLYCTDle
species: metaM amp r
reaction: metaR EX pheacgln LPAREN e RPAREN
reaction: metaR DOLMANP Uter
species: metaM val L m
species: metaM dgdp m
species: metaM sucsal m
species: metaM uri e
species: metaM adn m
reaction: metaR r1608
species: metaM co2 r
reaction: metaR VITD3t2
reaction: metaR H2Otn
reaction: metaR r1578
reaction: metaR PI45P5P
species: metaM xoltetrol m
species: metaM datp m
reaction: metaR AKR1D2
species: metaM arg L c
reaction: metaR RE2269E
species: metaM duri c
species: metaM lanost r
species: metaM bhb c
species: metaM ddsmsterol r
species: metaM CE2421 m
reaction: metaR r2081
reaction: metaR GMPR
reaction: metaR r0464
species: metaM ahcys e
reaction: metaR ICDHyrm
reaction: metaR BTNPLm
species: metaM apoC m
reaction: metaR r0514
reaction: metaR CYTK5n
species: metaM succ c
reaction: metaR r1649
species: metaM e4p c
species: metaM adrnl c
species: metaM CE0693 m
species: metaM c226crn m
reaction: metaR r2030
reaction: metaR r1546
species: metaM hista e
reaction: metaR ASCBOX
reaction: metaR EX cspg b LPAREN e RPAREN
reaction: metaR CLPNDCOAtx
species: metaM ctp n
reaction: metaR r2112
species: metaM pa hs m
species: metaM frdp r
reaction: metaR HXPRT
reaction: metaR EX HC00250 LPAREN e RPAREN
species: metaM tyr L e
species: metaM dmnoncrn x
reaction: metaR FAOXC121C10x
reaction: metaR r2520
species: metaM inost e
reaction: metaR CYTK7n
reaction: metaR r1669
species: metaM HC01522 c
reaction: metaR r0424
reaction: metaR GAMt1r
reaction: metaR SQLEr
species: metaM drib e
reaction: metaR CYTK5
reaction: metaR CO2ter
reaction: metaR r0021
reaction: metaR GGH 6THFe
species: metaM prostgh2 c
species: metaM btn c
reaction: metaR ADK3
reaction: metaR r1431
reaction: metaR CRNCARtp
reaction: metaR RBFK
species: metaM peamn c
species: metaM CE5788 e
reaction: metaR r0317

http://identifiers.org/biomodels.db/MODEL1310110025#_1a1011bf_a2c1_4b12_a44b_21be3ebac70d
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
is: A8K7J7
initial amount: NaN
has only substance units: false
boundary condition: true
name: HK1
is encoded by: hsa:3098

http://identifiers.org/biomodels.db/MODEL1310110025#_a3a8eb6c_fcaa_4125_8f7b_ef99ac1fd31a
boundary condition: true
constant: false
initial concentration: NaN
name: LDHB
is encoded by: hsa:3945
is: SBO:0000252
is: P07195
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_fb25a43d_bcc9_4c66_becf_cab542c29420
initial amount: NaN
is: Q16698
type: Species
constant: false
is: SBO:0000252
has only substance units: false
name: DECR1
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1666

metaM mag hs c
initial concentration: 1.0
constant: false
boundary condition: false
name: monoacylglycerol 2
initial amount: NaN
is: SBO:0000247
is: HMDB12130
has only substance units: false
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
is: CHEBI:16987
type: Species

metaR r1446
is described by: ECO:0000000
kinetic law: MODEL1310110025#
reversible: false
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
fast: false
type: Reaction
product: MODEL1310110025#
is: SBO:0000176
name: EC:1.3.3.6

metaR P5CRxm
fast: false
kinetic law: MODEL1310110025#
name: pyrroline-5-carboxylate reductase (m)
notes: GENE_ASSOCIATION: (5831.1) or (5831.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: NOTES:PRO1x is irreversible in the other direction
reactant: MODEL1310110025#
modifier: MODEL1310110025#
type: Reaction
reversible: false
is: SBO:0000176
product: MODEL1310110025#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.5.1.2

metaR r2081
reactant: MODEL1310110025#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110025#
type: Reaction
product: MODEL1310110025#
reversible: true
kinetic law: MODEL1310110025#
is: SBO:0000185

metaR r0784
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110025#
reversible: true
is version of: http://identifiers.org/ec-code/1.3.1.38
fast: false
reactant: MODEL1310110025#
type: Reaction
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:

metaR r0670
name: (S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
is: SBO:0000176
kinetic law: MODEL1310110025#
is described by: ECO:0000000
reversible: false
product: MODEL1310110025#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
reactant: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_e42b7388_f6c2_4d1d_b986_dda0491d5f10
has only substance units: false
is encoded by: hsa:493
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
is: P23634
name: ATP2B4
initial concentration: NaN
constant: false

metaR GCC2cm
modifier: MODEL1310110025#
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.8.1.4
is: SBO:0000176
name: glycine-cleavage complex (lipoamide), mitochondrial
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.1.2.10
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.4.2
reversible: true
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
fast: false
kinetic law: MODEL1310110025#
is described by: ECO:0000269

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_3af8e546_3afc_4d8f_8f6e_7615868eeb44
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AI684467
boundary condition: true
initial concentration: NaN
name: _AI684467_1_m
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_7079dfc2_7022_4ee4_b3bb_35159c9efd6b
is: Q9UG56
is: SBO:0000252
is encoded by: hsa:23761
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
name: PISD

metaM dcdp n
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
initial amount: NaN
is: HMDB01245
name: dCDP(3-)
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: CHEBI:58593
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_a44a00cf_81b8_4d4e_a151_3532b922df39
boundary condition: true
name: ACADVL
initial concentration: NaN
is encoded by: hsa:37
is: P49748
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
type: Species

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_8bfda13b_21a8_4528_beef_c98a4dc38d11
name: GCSH
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is: P23434
is: SBO:0000252
is encoded by: hsa:2653
constant: false
boundary condition: true

metaR MCPST
kinetic law: MODEL1310110025#
name: 3-mercaptopyruvate sulfurtransferase
is version of: http://identifiers.org/ec-code/2.8.1.2
modifier: MODEL1310110025#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.8.1.2 Confidence Level: 4 AUTHORS: PMID:4828222 NOTES:MM AMF. assay developed to find activity in red and white blood cells
type: Reaction
is: SBO:0000176
reactant: MODEL1310110025#
fast: false
product: MODEL1310110025#
reversible: false

metaM 3ohdcoa x
has only substance units: false
initial amount: NaN
name: 3-oxopalmitoyl-CoA(4-)
is: HMDB06402
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
is: CHEBI:57349
constant: false

metaM HC00342 c
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
name: cis-aconitate(3-)
boundary condition: false
is: CHEBI:16383
type: Species

metaM idour c
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
initial concentration: 1.0
is: CHEBI:21338
type: Species
constant: false
is: HMDB02704
is: SBO:0000247
boundary condition: false
name: L-iduronate

metaR r2080
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110025#
kinetic law: MODEL1310110025#
is: SBO:0000185
modifier: MODEL1310110025#
is described by: ECO:0000000
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
reactant: MODEL1310110025#

metaR r0783
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110025#
type: Reaction
modifier: MODEL1310110025#
product: MODEL1310110025#
fast: false

metaR EX nrpphr LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Norepinephrine exchange
type: Reaction

metaR r2193
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
type: Reaction
product: MODEL1310110025#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110025#
reversible: true

metaR RE1254C
reversible: true
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
fast: false
name: RE1254
is: SBO:0000176
kinetic law: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000000
type: Reaction

metaR r1443
name: EC:1.3.3.6
reactant: MODEL1310110025#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110025#
kinetic law: MODEL1310110025#
reversible: false

metaR SCPx
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reactant: MODEL1310110025#
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.3.1.176
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways NJ
fast: false
reversible: false
is described by: ECO:0000269
name: peroxisomal thiolase 2
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110025#_a3ee9f3e_1e1a_43e6_9059_af37599c9ed6
is encoded by: hsa:215
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: ABCD1
has only substance units: false
constant: false
is: SBO:0000252
type: Species
is: P33897

metaR r2116
is: SBO:0000185
kinetic law: MODEL1310110025#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reactant: MODEL1310110025#
is described by: ECO:0000000
product: MODEL1310110025#
modifier: MODEL1310110025#
type: Reaction
reversible: true

metaR RE0958E
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
name: RE0958
fast: false
reactant: MODEL1310110025#
is: SBO:0000176
modifier: MODEL1310110025#
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/3.2.1.17
is version of: http://identifiers.org/ec-code/3.2.1.1
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110025#

metaM cys L c
initial amount: NaN
name: L-cysteine
constant: false
is: CHEBI:17561
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB00574
boundary condition: false
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
initial concentration: 1.0

metaR DOLMANP Lter
name: dolichol-phosphate mannose flippase (liver)
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
reversible: false
type: Reaction
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
product: MODEL1310110025#
fast: false
is described by: ECO:0000000

metaM mag hs e
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:32391
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
has only substance units: false
constant: false
name: monoacylglycerol 2
is: SBO:0000247
is: HMDB03073
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110025#_bb7bb758_56d0_41fe_af40_4031b7e67555
is encoded by: hsa:4860
initial amount: NaN
type: Species
is: P00491
name: PNP
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_0dbdcc50_65aa_4500_8133_3b77f1354d44
name: _AI924226_1_m
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AI924226
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_63fd9473_4fe3_4ea0_8120_3afa5e422f0a
boundary condition: true
is: B3KXY9
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:3098
has only substance units: false
initial concentration: NaN
name: HK1
is: SBO:0000252

metaR MTHFD2m
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
kinetic law: MODEL1310110025#
reversible: true
is: SBO:0000176
type: Reaction
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
is version of: http://identifiers.org/ec-code/3.5.4.9
fast: false
product: MODEL1310110025#
modifier: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000254

metaR r0672
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.3.1.65
name: Cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase Bile acid biosynthesis EC:1.1.1.181
kinetic law: MODEL1310110025#
product: MODEL1310110025#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.181 Confidence Level: 0 AUTHORS: PMID:12679481 NOTES:
reactant: MODEL1310110025#
reversible: true
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110025#_daf32af2_caf8_4223_a246_9dd819825418
is: Q99943
is encoded by: hsa:10554
has only substance units: false
name: AGPAT1
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252

metaM HC02202 e
type: Species
constant: false
has only substance units: false
is: CHEBI:57398
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
initial concentration: 1.0
name: prostaglandin A1(1-)
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110025#_20082d78_eb16_4348_b38d_4983816f29c6
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:4701
constant: false
boundary condition: true
is: Q6FG42
name: NDUFA7

metaR r2117
is: SBO:0000185
kinetic law: MODEL1310110025#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reversible: true
reactant: MODEL1310110025#
product: MODEL1310110025#

metaM leuktrB4 e
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
name: leukotriene B4(1-)
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
is: HMDB01085
is: CHEBI:57461
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaM xol27oh m
initial amount: NaN
has only substance units: false
is: CHEBI:17703
name: 26-hydroxycholesterol
is: SBO:0000247
type: Species
boundary condition: false
constant: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
is: HMDB02103
initial concentration: 1.0

metaM tre e
initial amount: NaN
has only substance units: false
is: CHEBI:16551
is: C01083
initial concentration: 1.0
is: HMDB00975
type: Species
is: SBO:0000247
constant: false
name: Trehalose
boundary condition: false
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00658 EHMN_ABBREVIATION: C01083

metaR GLCAASE8ly
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
name: beta-glucuronidase, lysosomal
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/3.2.1.31
is: SBO:0000176
fast: false
type: Reaction

metaR r1641
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
kinetic law: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110025#

metaM 3pg c
is: C00197
type: Species
is: SBO:0000247
name: 3-Phospho-D-glycerate
is: CHEBI:58272
is: HMDB00807
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/3497

metaR r0680
product: MODEL1310110025#
modifier: MODEL1310110025#
reactant: MODEL1310110025#
reversible: true
is described by: ECO:0000000
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.137
type: Reaction
fast: false

metaR FRDPtr
reactant: MODEL1310110025#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
is described by: ECO:0000000
name: lipid, flip-flop intracellular transport
is: SBO:0000185
kinetic law: MODEL1310110025#
type: Reaction
product: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_1434d146_c9eb_425e_b3ca_200c3d5ae43c
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
name: ALDH9A1
is encoded by: hsa:223
is: P49189
constant: false
initial amount: NaN

metaM retinal cis 13 r
name: 13-cis-retinal
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
constant: false
is: SBO:0000247
is: HMDB06220
is: CHEBI:45487
boundary condition: false
initial concentration: 1.0

metaR ADNtm
is described by: ECO:0000269
reactant: MODEL1310110025#
product: MODEL1310110025#
kinetic law: MODEL1310110025#
name: adenosine facilated transport in mitochondria
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
is: SBO:0000185
modifier: MODEL1310110025#

metaM lnlncg r
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
has only substance units: false
is: CHEBI:32391
constant: false
is: HMDB03073
is: SBO:0000247
name: gamma-linolenate
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaR PSt3
reversible: true
kinetic law: MODEL1310110025#
fast: false
type: Reaction
is described by: ECO:0000269
name: phosphatidylserine transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110025#
is: SBO:0000185
product: MODEL1310110025#

metaR r2109
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110025#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110025#
reactant: MODEL1310110025#

metaM acetone m
name: acetone
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:15347
is: SBO:0000247
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
is: HMDB01659
initial concentration: 1.0
type: Species
has only substance units: false

metaR r1916
reactant: MODEL1310110025#
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110025#
name: Y+LAT2 Utilized transport
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: false

metaR 2OXOADOXm
is version of: http://identifiers.org/ec-code/2.3.1.61
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (4967.1) and (1738.1 and 8050.1) and (1743.1) or (4967.2) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Lysine metabolism EC Number: 2.3.1.61 Confidence Level: 2 AUTHORS: NOTES:SAB
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) (mitochondria)
is version of: http://identifiers.org/ec-code/1.2.4.2
reactant: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000304
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.8.1.4
type: Reaction
fast: false

metaR APAT2rm
kinetic law: MODEL1310110025#
type: Reaction
reactant: MODEL1310110025#
is: SBO:0000176
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 2.6.19.4 Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
reversible: true
name: 3-Aminopropanoate:2-oxoglutarate aminotransferase (m)
modifier: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000212
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.19

metaR EX idour LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-iduronate
type: Reaction

metaR SQLSr
name: Squalene synthase
kinetic law: MODEL1310110025#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ
product: MODEL1310110025#
is described by: ECO:0000134
fast: false
modifier: MODEL1310110025#
reversible: false
is version of: http://identifiers.org/ec-code/2.5.1.21
reactant: MODEL1310110025#

metaR EX psylchol LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for psyllium-glycocholic acid complex
type: Reaction

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

metaM 42A3HP24DB c
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
notes: FORMULA: C10H8NO5 CHARGE: -1 INCHI: InChI=1/C10H9NO5/c11-9-5(2-1-3-6(9)12)7(13)4-8(14)10(15)16/h1-3,12H,4,11H2,(H,15,16) HEPATONET_1.0_ABBREVIATION: HC01547 EHMN_ABBREVIATION: C05645
boundary condition: false
is: C05645
constant: false
is: http://identifiers.org/pubchem.compound/7956
is: HMDB04083
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN

metaR PCHOLPm hs
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
name: choline phosphatase
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.4
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
reversible: false
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110025#
fast: false

metaR r2443
product: MODEL1310110025#
fast: false
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
type: Reaction
is described by: ECO:0000000
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR r1642
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
kinetic law: MODEL1310110025#
reversible: true
product: MODEL1310110025#
type: Reaction
modifier: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_a37672ec_4145_4d53_af33_3ad1831b562e
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
name: HADHA
is encoded by: hsa:3030
type: Species
is: E9KL44

metaR r0456
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
reversible: false
is: SBO:0000176
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.7.1.32
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110025#
modifier: MODEL1310110025#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110025#_e6df011a_e67b_4f35_b699_ebd46e311a5a
is encoded by: hsa:AI934540
has only substance units: false
initial concentration: NaN
name: _AI934540_1_c
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_068ac0d8_5544_43dc_ab99_8f9fd206c45b
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:51727
boundary condition: true
constant: false
name: CMPK1
is: SBO:0000252
initial concentration: NaN
is: B2R6S5

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_07d5ea05_bd94_4c43_92eb_820d74903e23
name: ALDOB
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:229
constant: false
is: P05062
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110025#_030e931a_d44b_45f0_9056_4b5caf67e574
type: Species
boundary condition: true
has only substance units: false
name: AGPAT6
is: SBO:0000252
is encoded by: hsa:137964
constant: false
initial concentration: NaN
initial amount: NaN
is: Q86UL3

http://identifiers.org/biomodels.db/MODEL1310110025#_8fa6e1b4_da20_46f9_a1da_f63293a4d7fa
is encoded by: hsa:8527
initial amount: NaN
boundary condition: true
constant: false
type: Species
has only substance units: false
is: SBO:0000252
name: DGKD
initial concentration: NaN

metaR r2108
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110025#
product: MODEL1310110025#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
modifier: MODEL1310110025#
is: SBO:0000185
kinetic law: MODEL1310110025#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM CE5854 e
initial amount: NaN
type: Species
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
is: HMDB02710
constant: false
initial concentration: 1.0
name: gama-CEHC-glucuronide
is: SBO:0000247
has only substance units: false
is: CHEBI:27485
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110025#_a1e3a1f8_1c10_4377_86c8_e8457f6779bb
type: Species
initial amount: NaN
is: SBO:0000252
is: P06865
is encoded by: hsa:3073
initial concentration: NaN
boundary condition: true
constant: false
name: HEXA
has only substance units: false

metaM tststerone e
boundary condition: false
type: Species
initial amount: NaN
is: HMDB00234
has only substance units: false
is: SBO:0000247
is: CHEBI:17347
constant: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
name: testosterone
initial concentration: 1.0

metaM CE4876 r
boundary condition: false
is: CHEBI:12947
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
name: delta12-Prostaglandin J2
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_9fb6d078_6fbe_4a85_a383_103888575277
name: CA6
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: Q5FC00
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:765
type: Species

metaR EX cspg b LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan exchange
type: Reaction

metaR r1643
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000000
reactant: MODEL1310110025#
type: Reaction
reversible: true
is: SBO:0000185

metaR SPHS1Ptr
kinetic law: MODEL1310110025#
fast: false
name: sphingosine-1-phosphate transport
type: Reaction
reactant: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414 or PMID: 15585321). NJ
is: SBO:0000185

metaM cs a deg5 l
boundary condition: false
notes: FORMULA: C23H36O24S CHARGE: -2
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 5
is: SBO:0000247
is: CHEBI:15936
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_755c3680_b186_47f7_8eed_dcae6d6bd1e3
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:80025
name: PANK2
constant: false
type: Species

metaR r2321
is: SBO:0000185
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110025#
fast: false
product: MODEL1310110025#
is described by: ECO:0000000
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true

metaM dolichol U r
type: Species
is: CHEBI:16091
constant: false
name: Dolichol, human uterine homolog
boundary condition: false
notes: FORMULA: C1025H1680O10 CHARGE: 0
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaR DM T antigen g
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: DM T antigen(g)
type: Reaction

metaR FUMtm
kinetic law: MODEL1310110025#
name: fumarate transport, mitochondrial
type: Reaction
is described by: ECO:0000269
fast: false
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV
reversible: true
reactant: MODEL1310110025#
modifier: MODEL1310110025#
is: SBO:0000185

metaR q10tm
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
is described by: ECO:0000134
product: MODEL1310110025#
name: transport of ubiquinone into mitochondria
reversible: true
reactant: MODEL1310110025#
type: Reaction
kinetic law: MODEL1310110025#

metaM HC02207 e
is: CHEBI:27555
initial amount: NaN
name: prostaglandin-c2
type: Species
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110025#_ee32e45a_7bd1_4f8b_b232_cb4add0c4747
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: PLCD4
type: Species
constant: false
is: Q9BRC7
is encoded by: hsa:84812
is: SBO:0000252

metaR RE0452M
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.9 Confidence Level: 0 AUTHORS: PMID:8024690 NOTES:
kinetic law: MODEL1310110025#
name: RE0452
fast: false
is: SBO:0000176
type: Reaction
reversible: true
product: MODEL1310110025#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110025#_158abe3d_3df6_4850_a429_c50da9b4122a
type: Species
name: GGT5
is encoded by: hsa:2687
constant: false
boundary condition: true
is: P36269
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaM hcys L c
has only substance units: false
name: L-homocysteine
type: Species
is: CHEBI:17588
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB00742
initial concentration: 1.0
notes: FORMULA: C4H9NO2S CHARGE: 0 INCHI: InChI=1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00151
initial amount: NaN

metaM cs b deg1 l
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
is: CHEBI:57455
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB01354
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 1
initial concentration: 1.0
initial amount: NaN
type: Species

metaR r1644
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110025#
product: MODEL1310110025#
modifier: MODEL1310110025#
reactant: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_9fee2bc2_5283_447b_9200_fc6c73637cff
has only substance units: false
initial amount: NaN
name: ALDH2
is: P05091
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:217
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110025#_6c5b08a0_ef4f_40e7_a2ae_d2c196bd2a06
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: P09172
boundary condition: true
name: DBH
is encoded by: hsa:1621

metaR PSYGCHe
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: binding of psyllium with glycocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

metaR r2320
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110025#
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR EX fald LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of formaldehyde
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_2bc6a8d8_445b_41ab_82b8_97c3830d18e5
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:116285
has only substance units: false
type: Species
initial amount: NaN
name: ACSM1
is: Q08AH1
initial concentration: NaN

metaR r0009
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
fast: false
kinetic law: MODEL1310110025#
reversible: false
modifier: MODEL1310110025#
type: Reaction
is: SBO:0000176
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/3.6.1.1
is described by: ECO:0000000

metaR RE2999M
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE2999
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
product: MODEL1310110025#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/5.3.3.8
kinetic law: MODEL1310110025#
reversible: true
modifier: MODEL1310110025#
reactant: MODEL1310110025#

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

metaM HC00695 m
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
boundary condition: false
is: CHEBI:17432
name: S-Succinyldihydrolipoamide

http://identifiers.org/biomodels.db/MODEL1310110025#_451b6591_a5da_462e_a155_dae4eba63864
type: Species
initial amount: NaN
is: SBO:0000252
name: DEGS1
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:8560
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_0b280a97_2ec4_4c1f_af96_69f3c4281ed9
is encoded by: hsa:1349
has part: P00414
initial amount: NaN
has part: P24310
has part: P24311
initial concentration: NaN
is encoded by: hsa:1345
has part: Q6FGA0
is encoded by: hsa:125965
has part: Q7GXZ8
has part: P12074
is encoded by: hsa:1347
is encoded by: hsa:84701
is encoded by: hsa:1340
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
has part: H0UI06
has part: Q7Z4L0
is: SBO:0000297
boundary condition: true
has part: P13073
is encoded by: hsa:4514
has only substance units: false
is encoded by: hsa:9167
has part: P09669
has part: Q96KJ9
type: Species
has part: P14854
has part: P20674
is encoded by: hsa:341947
has part: Q8TF08
has part: Q53YB7
is encoded by: hsa:4512
is encoded by: hsa:170712
is encoded by: hsa:1351
has part: Q7GXY8
has part: Q6YFQ2
has part: Q53XN1
is encoded by: hsa:1346
is encoded by: hsa:1337
has part: Q02221
is encoded by: hsa:1339
has part: P15954
is encoded by: hsa:4513
is encoded by: hsa:1329
is encoded by: hsa:1350
is encoded by: hsa:1327
constant: false
is encoded by: hsa:9377

metaR r2323
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
product: MODEL1310110025#
reversible: true
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110025#_e98df261_7b52_426c_804b_c6e6d386c050
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
is: B1AM93
name: NDUFA8
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:4702

metaR r0085
is version of: http://identifiers.org/ec-code/1.1.1.42
is: SBO:0000176
product: MODEL1310110025#
modifier: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
type: Reaction
kinetic law: MODEL1310110025#
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
is described by: ECO:0000000
reversible: false
fast: false

metaR r1396
is: SBO:0000176
name: EC:2.3.1.21
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
product: MODEL1310110025#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110025#_bf1d6d71_43fb_44b3_92be_1bea3d460eda
initial amount: NaN
is encoded by: hsa:23464
type: Species
name: GCAT
is: SBO:0000252
constant: false
has only substance units: false
is: E2QC23
boundary condition: true
initial concentration: NaN

metaM his L m
has only substance units: false
name: L-histidine
constant: false
is: HMDB00177
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15971
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110025#_f68592b3_c862_44b6_ab53_52e704a03aec
is: Q14032
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
name: BAAT
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:570

metaM 34dhoxmand m
is: CHEBI:27637
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: 3,4-Dihydroxymandelate
has only substance units: false
initial amount: NaN
type: Species
is: HMDB01866
constant: false

metaM HC02207 c
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
name: prostaglandin-c2
is: SBO:0000247
constant: false
is: CHEBI:27555
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955

http://identifiers.org/biomodels.db/MODEL1310110025#_84aa0ea2_7eeb_4486_a476_23c7249fd3b0
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:AL525798
type: Species
constant: false
is: SBO:0000252
name: _AL525798_1_c
has only substance units: false

metaM glyc c
is: HMDB00131
is: CHEBI:17754
is: C00116
is: SBO:0000247
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
name: Glycerol
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110025#_ea9fbf94_c1d1_48fc_a7b1_54e3d474394b
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:686
name: BTD
type: Species
boundary condition: true
is: P43251

metaM h2o2 m
is: C00027
boundary condition: false
name: Hydrogen peroxide
constant: false
is: SBO:0000247
is: HMDB03125
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: CHEBI:16240

metaR CGLYt3 2
type: Reaction
modifier: MODEL1310110025#
is: SBO:0000185
kinetic law: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB
is described by: ECO:0000304
product: MODEL1310110025#
reactant: MODEL1310110025#
name: Cys-Gly transport in via proton symport
reversible: false

metaM nrpphr e
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:33569
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
is: SBO:0000247
is: HMDB00216
initial concentration: 1.0
boundary condition: false
constant: false
name: Norepinephrine

metaR r0086
reactant: MODEL1310110025#
reversible: false
fast: false
modifier: MODEL1310110025#
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
is: SBO:0000176
kinetic law: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
product: MODEL1310110025#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.5.1.3

metaR r2322
type: Reaction
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110025#
product: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_8dc72e0d_a3f8_4d79_832a_414dc5bbb73c
constant: false
has only substance units: false
is encoded by: hsa:84532
type: Species
initial concentration: NaN
boundary condition: true
name: ACSS1
initial amount: NaN
is: SBO:0000252
is: Q9NUB1

http://identifiers.org/biomodels.db/MODEL1310110025#_44660db6_891f_41ce_bb65_51fd9ccedc01
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:83884
constant: false
name: SLC25A2
is: Q9BXI2
boundary condition: true
initial amount: NaN

metaM glyc e
is: HMDB00131
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:17754
is: C00116
type: Species
initial concentration: 1.0
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
name: Glycerol

metaM dcmp c
boundary condition: false
initial amount: NaN
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
name: dCMP
is: C00239
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB01202
type: Species
is: CHEBI:57566
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110025#_95228072_d5dc_4347_96e7_b623c7fac20e
is: SBO:0000252
type: Species
initial amount: NaN
name: CTPS1
boundary condition: true
is: P17812
constant: false
initial concentration: NaN
is encoded by: hsa:1503
has only substance units: false

metaR EX tststerone LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Testosterone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_af29f17f_a0b3_47b6_8ae9_ed9f3fe246b7
initial amount: NaN
constant: false
type: Species
name: DHCR7
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: Q9UBM7
is encoded by: hsa:1717
boundary condition: true

metaM Sfglutth c
is: HMDB01550
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
name: S-formylglutathionate(1-)
is: CHEBI:57688
constant: false
type: Species

metaR r1397
name: carnitine acetyltransferase EC:2.3.1.7
reactant: MODEL1310110025#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110025#_980cea05_e9c3_4ec0_9d20_9a3b62b5d958
type: Species
is: O15305
name: PMM2
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5373

http://identifiers.org/biomodels.db/MODEL1310110025#_6e8b5ed0_3175_4b5b_bc48_9daa26bdd62c
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:4645
is: Q9H6Y6
has only substance units: false
name: MYO5B
is: SBO:0000252
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_1b8d9348_473c_42c8_a4ff_31a8c1b75e50
is: SBO:0000252
is: P16219
constant: false
type: Species
is encoded by: hsa:35
initial concentration: NaN
initial amount: NaN
name: ACADS
boundary condition: true
has only substance units: false

metaR r2325
type: Reaction
reactant: MODEL1310110025#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110025#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110025#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR RPEc
reversible: true
is: SBO:0000176
is described by: ECO:0000134
fast: false
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
type: Reaction
kinetic law: MODEL1310110025#
name: ribulose 5-phosphate 3-epimerase
reactant: MODEL1310110025#

metaM 56dura c
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
type: Species
is: CHEBI:15901
has only substance units: false
is: HMDB00076
name: 5,6-dihydrouracil
is: SBO:0000247
boundary condition: false
constant: false

metaR r0083
modifier: MODEL1310110025#
product: MODEL1310110025#
kinetic law: MODEL1310110025#
is: SBO:0000176
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
reversible: true
reactant: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.42

http://identifiers.org/biomodels.db/MODEL1310110025#_a7722acd_b950_42ef_8d93_49055b625aa7
initial concentration: NaN
is: P28329
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
constant: false
boundary condition: true
name: CHAT
is encoded by: hsa:1103

http://identifiers.org/biomodels.db/MODEL1310110025#_df056bf9_2d8b_4616_ae7d_250d01f69418
is encoded by: hsa:51205
is: Q9NPH0
has only substance units: false
initial amount: NaN
constant: false
type: Species
name: ACP6
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR H2Oter
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110025#
reversible: true
name: H2O endoplasmic reticulum transport
type: Reaction
is described by: ECO:0000000
product: MODEL1310110025#
kinetic law: MODEL1310110025#

metaM nrpphr c
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
type: Species
is: CHEBI:33569
is: SBO:0000247
name: Norepinephrine
initial concentration: 1.0
boundary condition: false
is: HMDB00216

http://identifiers.org/biomodels.db/MODEL1310110025#_57a3c1f2_d06a_45b8_b3a9_0f670842dd14
is: P00326
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: ADH1C
constant: false
boundary condition: true
is encoded by: hsa:126

metaM m2emgacpail hs r
name: (dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (H6)
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: C00080
is: http://identifiers.org/pubchem.compound/3380
is: CHEBI:24636
initial concentration: 1.0
type: Species
notes: FORMULA: C51H94N2O32P2FULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false

metaM Ssq23epx r
name: (S)-2,3-epoxysqualene
is: HMDB01188
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: CHEBI:15441
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-24(2)14-11-17-27(5)20-12-18-25(3)15-9-10-16-26(4)19-13-21-28(6)22-23-29-30(7,8)31-29/h14-16,20-21,29H,9-13,17-19,22-23H2,1-8H3/b25-15+,26-16+,27-20+,28-21+/t29-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00645 EHMN_ABBREVIATION: C01054
boundary condition: false

metaR r2324
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
reversible: true
is: SBO:0000185
fast: false
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110025#
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#

metaM HC01434 x
constant: false
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
type: Species
name: oxalatosuccinate(3-)
boundary condition: false
is: CHEBI:58931
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR r1640
reactant: MODEL1310110025#
is described by: ECO:0000000
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110025#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110025#
reversible: true
fast: false

metaR r0084
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
product: MODEL1310110025#
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.1.1.42
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is: SBO:0000176
modifier: MODEL1310110025#
fast: false
type: Reaction
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110025#_cff749b7_50ab_4e14_a35a_b6fbe3b3d9fc
constant: false
is encoded by: hsa:501
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is: E7EPT3
initial amount: NaN
name: ALDH7A1

http://identifiers.org/biomodels.db/MODEL1310110025#_5129624d_6de3_46e0_ab62_d1f7ef0bb057
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:AA788780
name: _AA788780_1_c
boundary condition: true
is: SBO:0000252
type: Species

metaR GGT6
product: MODEL1310110025#
name: Gamma-glutamyltransferase
kinetic law: MODEL1310110025#
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
reactant: MODEL1310110025#

metaM HC01410 m
initial concentration: 1.0
is: CHEBI:28706
boundary condition: false
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
initial amount: NaN
constant: false
name: (2E)-Hexenoyl-CoA
is: SBO:0000247
type: Species
has only substance units: false

metaM tststerone c
is: HMDB00234
is: SBO:0000247
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
is: CHEBI:17347
has only substance units: false
name: testosterone

metaM nh4 m
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: C01342
is: HMDB00051
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:28938
is: SBO:0000247
name: Ammonium
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_9ead5c02_8ee9_427e_b6c4_cf759d7ac6d7
is: Q9HC58
initial concentration: NaN
is: SBO:0000252
name: SLC24A3
boundary condition: true
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:57419
has only substance units: false

metaR CHLPCTD
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.7.7.15
reversible: false
name: choline phosphate cytididyltransferase
type: Reaction
modifier: MODEL1310110025#
reactant: MODEL1310110025#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5130.1) or (9468.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.15 Confidence Level: 4 AUTHORS: NOTES:NCD
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110025#

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

metaM hco3 e
name: Bicarbonate
is: C00288
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: HMDB00595
initial concentration: 1.0
is: CHEBI:17544

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_b46a437a_92ce_436d_b77c_7c658c33104e
boundary condition: true
constant: false
name: NT5C2
initial amount: NaN
is: P49902
is encoded by: hsa:22978
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252

metaR r1649
is described by: ECO:0000000
type: Reaction
product: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110025#
is: SBO:0000185
reactant: MODEL1310110025#
reversible: true
fast: false
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110025#_139d750c_c7b3_4a0e_a12d_e076f82aa9d2
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:112
is: SBO:0000252
name: ADCY6

metaM thcholstoic x
is: HMDB03873
constant: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
initial concentration: 1.0
initial amount: NaN
is: CHEBI:18402
is: SBO:0000247
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
has only substance units: false
boundary condition: false
type: Species

metaR 3MLDAt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11411609 NOTES:SAB
reactant: MODEL1310110025#
reversible: true
is described by: ECO:0000000
name: 3MLDA extracellular transport via diffusion
fast: false
is: SBO:0000185
product: MODEL1310110025#
kinetic law: MODEL1310110025#
type: Reaction

metaM glu L m
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
initial concentration: 1.0
type: Species
name: L-glutamate(1-)
is: SBO:0000247
boundary condition: false
is: CHEBI:29985
is: HMDB00148
constant: false
has only substance units: false
initial amount: NaN

metaR r1862
kinetic law: MODEL1310110025#
type: Reaction
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
modifier: MODEL1310110025#
fast: false
name: Y+LAT2 Utilized transport
reactant: MODEL1310110025#
reversible: false
is described by: ECO:0000000

metaR AICART
is: SBO:0000176
kinetic law: MODEL1310110025#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
modifier: MODEL1310110025#
fast: false
reactant: MODEL1310110025#
product: MODEL1310110025#
reversible: true
name: phosphoribosylaminoimidazolecarboxamide formyltransferase
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.2.3

metaR r1581
fast: false
reactant: MODEL1310110025#
is: SBO:0000185
product: MODEL1310110025#
is described by: ECO:0000000
kinetic law: MODEL1310110025#
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM acetone e
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB01659
constant: false
is: CHEBI:15347
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
name: acetone
initial concentration: 1.0

metaR r0113
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/6.2.1.1
modifier: MODEL1310110025#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 0 AUTHORS: PMID:10431835,PMID:15748884,PMID:3740419,PMID:4337336,PMID:5063602,PMID:5417402,PMID:9305887,PMID:9305888 NOTES:
name: UDP-N-acetyl-D-glucosamine 2-epimerase Aminosugars metabolism EC:5.1.3.14
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110025#

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

metaM 10fthf7glu e
has only substance units: false
type: Species
notes: FORMULA: C50H57N13O25 CHARGE: -8
boundary condition: false
is: CHEBI:57454
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00972
name: 10-formyltetrahydrofolate-[Glu](7)
is: SBO:0000247

metaR M4BTAer
is: SBO:0000176
notes: GENE_ASSOCIATION: (10026.1) and (128869.1) and (8733.1) and (94005.1) and (51604.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10727241,PMID:11483512,PMID:12802054,PMID:15208306,PMID:9356492,PMID:9468317 NOTES:EC 2.6.-.- NCD
reactant: MODEL1310110025#
modifier: MODEL1310110025#
is described by: ECO:0000000
product: MODEL1310110025#
kinetic law: MODEL1310110025#
name: M4B transamidase, endoplasmic reticulum
type: Reaction
reversible: false
fast: false

metaM zym int2 r
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-20,23-24H,6,8-17H2,1-5H3/t19-,20+,23-,24+,26+,27-/m1/s1
type: Species
constant: false
has only substance units: false
is: CHEBI:52386
initial concentration: 1.0
boundary condition: false
name: zymosterol intermediate 2

metaR ACACT7p
fast: false
reactant: MODEL1310110025#
name: acetyl-CoA acyltransferase (tetradecanoyl-CoA), peroxisomal
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: false
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
product: MODEL1310110025#

metaR r1318
fast: false
product: MODEL1310110025#
kinetic law: MODEL1310110025#
type: Reaction
reactant: MODEL1310110025#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reversible: true
name: Transport reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_a6f9dee2_1417_4b8d_ae6d_82e72514a8ed
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AI435857
boundary condition: true
type: Species
initial concentration: NaN
name: _AI435857_1_x

http://identifiers.org/biomodels.db/MODEL1310110025#_1dd36512_a7a4_4de0_9cbf_923626a67114
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:23428
has only substance units: false
type: Species
constant: false
boundary condition: true
is: Q86U05
name: SLC7A8
is: SBO:0000252

metaR r1580
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
reactant: MODEL1310110025#
type: Reaction
is: SBO:0000185
product: MODEL1310110025#

metaM nh4 x
type: Species
is: SBO:0000247
is: C01342
boundary condition: false
is: CHEBI:28938
initial amount: NaN
constant: false
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
has only substance units: false
is: HMDB00051
name: Ammonium
initial concentration: 1.0

metaR ACGAMK
is version of: http://identifiers.org/ec-code/2.7.1.59
is: SBO:0000176
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
product: MODEL1310110025#
name: N-acetylglucosamine kinase
notes: GENE_ASSOCIATION: (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.59 Confidence Level: 4 AUTHORS: PMID:10824116 NOTES:
fast: false
type: Reaction
reversible: false
modifier: MODEL1310110025#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110025#_e3a34029_e444_4fe0_a343_1c35ed1edcc8
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:66035
initial amount: NaN
type: Species
name: SLC2A11
is: Q8WXF9

metaR LSTO1r
is described by: ECO:0000269
modifier: MODEL1310110025#
product: MODEL1310110025#
reversible: false
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.14.21.6
type: Reaction
name: Lathosterol oxidase
reactant: MODEL1310110025#

metaR THRGLYexR
is described by: ECO:0000304
is: SBO:0000185
fast: false
name: L-threonine/glycine reversible exchange
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
reversible: true
type: Reaction
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110025#

metaR r1583
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110025#
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
is: SBO:0000185

metaM ru5p D r
type: Species
name: D-ribulose 5-phosphate(2-)
has only substance units: false
initial concentration: 1.0
is: HMDB00618
is: CHEBI:58121
initial amount: NaN
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
is: SBO:0000247
boundary condition: false
constant: false

metaR RE3245C
reversible: true
is described by: ECO:0000000
name: RE3245
kinetic law: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton
reactant: MODEL1310110025#
type: Reaction
product: MODEL1310110025#
is: SBO:0000176

metaM acetone c
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB01659
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
is: CHEBI:15347
name: acetone
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110025#_b99ef6c9_425c_46fc_b581_f54171a7e430
initial amount: NaN
is encoded by: hsa:191
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
is: B3KUN3
name: AHCY

metaR MCLOR
is: SBO:0000176
name: 3-Mercaptolactate:NAD+ oxidoreductase
notes: GENE_ASSOCIATION: (92483.1) or (3945.1 and 3939.1) or (55293.1) or (3948.2) or (3948.1) or (3945.1) or (160287.1) or (3939.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:7054184 NOTES:
reactant: MODEL1310110025#
modifier: MODEL1310110025#
product: MODEL1310110025#
kinetic law: MODEL1310110025#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.27
type: Reaction
is described by: ECO:0000269

metaR LEUKTRF4t
name: leukotriene F4 transport
product: MODEL1310110025#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110025#
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110025#

metaR FAOXC204
product: MODEL1310110025#
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
is: SBO:0000176
reversible: false
name: Beta oxidation of long chain fatty acid
modifier: MODEL1310110025#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (35.1) or (35.1) or (34.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

metaM prostge2 c
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
is: CHEBI:606564
has only substance units: false
initial amount: NaN
name: prostaglandin E2(1-)
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB01220
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_a11b0f98_2218_40ac_a897_c40bedeabef5
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:T83654
is: SBO:0000252
name: _T83654_1_c
constant: false
initial concentration: NaN

metaR ACNAM9PL
is version of: http://identifiers.org/ec-code/2.5.1.56
is: SBO:0000176
notes: GENE_ASSOCIATION: (54187.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.5.1.56 Confidence Level: 4 AUTHORS: PMID:10749855 NOTES:EC-2.5.1.56 NCD
modifier: MODEL1310110025#
fast: false
reversible: false
name: N-Acetylneuraminate 9-phosphate pyruvate-lyase (pyruvate-phosphorylating)
is described by: ECO:0000269
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
type: Reaction
product: MODEL1310110025#

metaR r0193
is: SBO:0000176
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
kinetic law: MODEL1310110025#
type: Reaction
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
is described by: ECO:0000000
reactant: MODEL1310110025#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110025#_588770a7_c397_4d33_9efd_421a4c0311c3
initial concentration: NaN
is encoded by: hsa:AI697028
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
name: _AI697028_1_m

metaM CE0713 m
name: 3-oxolinoleoyl-CoA
has only substance units: false
is: SBO:0000247
is: CHEBI:30623
boundary condition: false
is: HMDB02329
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_b0a74fb4_119a_440a_9f91_a478ba634479
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:6240
is: SBO:0000252
constant: false
has only substance units: false
name: RRM1
initial concentration: NaN
is: P23921

metaM 4nph e
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:57917
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
is: HMDB01232
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
name: 4-nitrophenolate

metaR S4TASE1ly
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/3.1.6.12
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
is described by: ECO:0000000
reversible: true
is: SBO:0000176
name: N-acetylgalactosamine-4-sulfatase, lysosomal
fast: false
product: MODEL1310110025#
type: Reaction
modifier: MODEL1310110025#

metaR r0345
is described by: ECO:0000000
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
is: SBO:0000176
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
modifier: MODEL1310110025#
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110025#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.13
is version of: http://identifiers.org/ec-code/1.3.3.6
reversible: true

metaM HC01180 c
is: SBO:0000247
type: Species
name: D-tagatofuranose 1,6-bisphosphate(4-)
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-4-3(1-16-19(10,11)12)18-6(9,5(4)8)2-17-20(13,14)15/h3-5,7-9H,1-2H2,(H2,10,11,12)(H2,13,14,15)/p-4/t3-,4+,5+,6?/m1/s1 EHMN_ABBREVIATION: C03785
is: CHEBI:58694
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_17133898_88e4_4e28_bfa0_32b56b07d71e
is: SBO:0000252
boundary condition: true
has only substance units: false
name: _AI971036_1_m
initial concentration: NaN
is encoded by: hsa:AI971036
constant: false
type: Species
initial amount: NaN

metaR r1645
is: SBO:0000185
reversible: true
modifier: MODEL1310110025#
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110025#
product: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_5676dac5_98b3_4019_86ae_fe4440f33c08
is encoded by: hsa:D29675
boundary condition: true
type: Species
constant: false
name: _D29675_1_e
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_5a0a4f05_2aac_4ad4_83e3_2bf8b69a712a
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:56623
boundary condition: true
is: Q9NRR6
name: INPP5E

http://identifiers.org/biomodels.db/MODEL1310110025#_2c6c05bf_188b_43af_990f_0ba1e9c57c42
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
name: _AA419122_1_c
is encoded by: hsa:AA419122
has only substance units: false

metaM 5htrp c
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643
is: HMDB00472
type: Species
is: SBO:0000247
boundary condition: false
name: 5-hydroxy-L-tryptophan
is: CHEBI:17780
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false

metaR RE2660N
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.96
name: RE2660
reactant: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
kinetic law: MODEL1310110025#
is: SBO:0000176
product: MODEL1310110025#
modifier: MODEL1310110025#
is described by: ECO:0000000
reversible: true

metaM leuktrF4 c
type: Species
constant: false
has only substance units: false
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
boundary condition: false
name: leukotriene F4
is: HMDB06465
initial amount: NaN
is: CHEBI:27491
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110025#_413f98f0_686b_4c75_8f41_0c63e9c4e5fa
has only substance units: false
constant: false
is encoded by: hsa:84701
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q96KJ9
name: COX4I2
boundary condition: true

metaR HIBDm
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.31
reversible: true
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
is: SBO:0000176
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
is described by: ECO:0000269
reactant: MODEL1310110025#
type: Reaction
product: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_aec5df43_5d1a_48f3_8ad0_7acdadc02eee
has only substance units: false
boundary condition: true
is encoded by: hsa:1340
initial amount: NaN
is: P14854
initial concentration: NaN
constant: false
name: COX6B1
type: Species
is: SBO:0000252

metaR CYTK3n
is: SBO:0000176
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000269
name: cytidylate kinase (dCMP,CTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_c5cd6d14_6d7f_47d2_b001_fb3838d25633
is: SBO:0000252
is encoded by: hsa:6549
constant: false
type: Species
initial concentration: NaN
is: Q9UBY0
boundary condition: true
initial amount: NaN
has only substance units: false
name: SLC9A2

MODEL1310110025#
species: metaM so4 e
species: metaM nadh r
species: metaM acgal l
species: metaM phe L c
species: metaM CE2705 n
species: metaM dag hs e
species: metaM 3pg c
species: metaM pmtcoa m
species: metaM HC02216 c
species: metaM rbt e
species: metaM HC00718 c
species: metaM nicrnt c
name: ACAA1:HSD17B4:ACOX1
species: metaM ala D e
species: metaM o2 c
species: metaM HC02208 c
species: metaM c226coa m
species: metaM gtp m
stoichiometry: 5.0
species: metaM coa m
species: metaM dadp m
species: metaM dgsn c
stoichiometry: 0.002914
species: metaM triodthy e
species: metaM asn L e
species: metaM acgal c
species: metaM dolmanp U c
species: metaM pd3 c
species: metaM HC02180 e
species: metaM bilglcur c
species: metaM CE0785 m
species: metaM pe hs e
species: metaM itacon m
species: metaM fol e
species: metaM phe L e
species: metaM thymd c
species: metaM trdrd m
species: metaM cdpchol c
species: metaM sprm c
species: metaM succ c
species: metaM hista c
species: metaM HC01376 m
species: metaM val L m
species: metaM 4mzym int1 r
species: metaM fol m
species: metaM HC00250 c
species: metaM Rtotal e
species: metaM gua c
species: metaM dutp m
species: metaM biocyt m
species: metaM C02470 c
species: metaM tststerone e
species: metaM cbasp e
species: metaM dcdp n
species: metaM leuktrC4 c
species: metaM 34hpp e
stoichiometry: 1.96
species: metaM xoltriol m
species: metaM 3ohdcoa x
species: metaM 2mcit c
species: metaM lys L m
species: metaM gly e
species: metaM alpa hs c
species: metaM xoldioloneh c
species: metaM 6pgc r
species: metaM amet c
species: metaM retinol c
species: metaM 3mlda e
species: metaM apoC Lys c
species: metaM cys L e
species: metaM Ser Gly Ala X Gly l
species: metaM glyc c
species: metaM asp L c
species: metaM cl c
species: metaM dpcoa c
species: metaM prostgf2 e
species: metaM Rtotal2coa c
species: metaM amp e
species: metaM estradiol r
species: metaM pheacgln c

http://identifiers.org/biomodels.db/MODEL1310110025#_3502b91f_6179_4389_aa0b_aed633b2bcfc
initial amount: NaN
is encoded by: hsa:T83654
has only substance units: false
boundary condition: true
name: _T83654_1_e
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species

metaR RTOTAL2t
kinetic law: MODEL1310110025#
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
name: RTOTAL2 transport
fast: false
is described by: ECO:0000000
reactant: MODEL1310110025#
product: MODEL1310110025#

metaR r1585
product: MODEL1310110025#
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#

metaM apoC Lys btn m
is: C05552
initial amount: NaN
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
notes: FORMULA: C16H27N4O3SX CHARGE: 0
is: http://identifiers.org/pubchem.compound/7886
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
constant: false
is: HMDB03134

metaM dolp L c
initial amount: NaN
type: Species
constant: false
is: CHEBI:57683
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: dolichyl phosphate(2-)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_dcf3df7d_f720_4478_81fb_06be8c58abfb
initial amount: NaN
name: RDH5
is encoded by: hsa:5959
is: Q92781
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species

metaM prostge2 e
initial amount: NaN
is: CHEBI:606564
type: Species
has only substance units: false
is: SBO:0000247
name: prostaglandin E2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB01220

http://identifiers.org/biomodels.db/MODEL1310110025#_b329f5b8_86ac_467c_a128_13659d4655ce
is: SBO:0000252
is encoded by: hsa:57786
has only substance units: false
initial concentration: NaN
name: RBAK
constant: false
type: Species
initial amount: NaN
boundary condition: true
is: Q9NYW8

metaR r1646
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110025#
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110025#

metaM 44mctr r
is: SBO:0000247
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
constant: false
initial amount: NaN
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB01023
has only substance units: false
is: CHEBI:17813

metaM xoldioloneh c
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB06887
name: 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one
constant: false
initial concentration: 1.0
is: CHEBI:2288
has only substance units: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-18,20-25,29-30H,6-15H2,1-5H3/t17-,18+,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01462 EHMN_ABBREVIATION: C05453

http://identifiers.org/biomodels.db/MODEL1310110025#_8ab9467b_dbbe_42dc_a9eb_aa9465c0a7e4
has only substance units: false
name: HK1
is: Q59FD4
constant: false
is encoded by: hsa:3098
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_1df5e4b2_b276_4e2e_82a0_3ea1481df578
initial concentration: NaN
is: Q9UJ70
has only substance units: false
is encoded by: hsa:55577
is: SBO:0000252
type: Species
boundary condition: true
constant: false
name: NAGK
initial amount: NaN

metaR AKGt4 3
notes: GENE_ASSOCIATION: (64849.1) or (64849.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10099705,PMID:10794676 NOTES:NCD
reactant: MODEL1310110025#
product: MODEL1310110025#
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110025#
fast: false
type: Reaction
reversible: true
name: AKG transport via sodium symport
modifier: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_9a93ffb8_30e5_4954_92c6_3e999f94f7e0
is encoded by: hsa:80347
is: SBO:0000252
name: COASY
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: Q13057
has only substance units: false
type: Species

metaM h2o2 c
is: C00027
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:16240
name: Hydrogen peroxide
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
type: Species
is: HMDB03125
is: SBO:0000247
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_acb7a1df_497f_4faa_a950_f39cddbd679f
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AV717590
constant: false
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: _AV717590_1_m

metaM xol27oh r
type: Species
is: SBO:0000247
constant: false
is: CHEBI:17703
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: 26-hydroxycholesterol
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
is: HMDB02103

metaR LNLCCRNt
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110025#
product: MODEL1310110025#
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110025#
type: Reaction
name: transport into the mitochondria (carnitine)
reactant: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_f71268a2_03fe_415f_9ad8_70f069d7e4ee
is: SBO:0000252
constant: false
initial amount: NaN
name: AKR1C4
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1109
is: P17516

http://identifiers.org/biomodels.db/MODEL1310110025#_77859cc0_b820_4996_969c_6c42063410ac
type: Species
name: ALPI
constant: false
is: P09923
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:248

http://identifiers.org/biomodels.db/MODEL1310110025#_72d971e8_f041_4e02_87ce_b83110ea6e25
has only substance units: false
initial amount: NaN
type: Species
name: _R06874_1_r
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:R06874

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_0d30e2ca_7c99_48f4_9de8_6af1c3644b85
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: CHKB
is: A0PJM6
is encoded by: hsa:1120
has only substance units: false
is: SBO:0000252
constant: false
type: Species

metaR r1584
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000000
product: MODEL1310110025#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR RE0915E
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.17
name: RE0915
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
modifier: MODEL1310110025#
reactant: MODEL1310110025#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.1
fast: false
product: MODEL1310110025#

metaM taur e
constant: false
notes: FORMULA: C2H7NO3S CHARGE: 0
type: Species
boundary condition: false
has only substance units: false
name: Taurine
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:3544
is: C00245
is: HMDB00251

metaM glyc m
has only substance units: false
initial amount: NaN
constant: false
name: Glycerol
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: CHEBI:17754
is: HMDB00131
is: C00116

metaR r0570
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
product: MODEL1310110025#
reactant: MODEL1310110025#
type: Reaction
reversible: true
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/6.3.3.2
is described by: ECO:0000000
is: SBO:0000176
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
fast: false

http://identifiers.org/biomodels.db/MODEL1310110025#_5b9bdef7_8b1e_4c54_a690_b3a2b043a301
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:HG2846-HT2983
name: _HG2846_HT2983_1_m

metaR r1647
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110025#
fast: false
product: MODEL1310110025#
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

metaR FAOXC121C10x
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C12:1-->C10)x
type: Reaction

metaR H4ETer
notes: GENE_ASSOCIATION: (23556.1) or (23556.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10574991 NOTES:NCD
product: MODEL1310110025#
fast: false
type: Reaction
kinetic law: MODEL1310110025#
is described by: ECO:0000000
modifier: MODEL1310110025#
reversible: false
name: H4 phosphoethanolaminyl transferase, endoplasmic reticulum
reactant: MODEL1310110025#
is: SBO:0000176

metaR DNDPt14m
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110025#
is described by: ECO:0000269
modifier: MODEL1310110025#
name: dUDP transport via dTDP antiport
kinetic law: MODEL1310110025#
type: Reaction
product: MODEL1310110025#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110025#_b5428dd7_891f_4e32_b870_83819db4da78
type: Species
boundary condition: true
name: SLC16A10
is: SBO:0000252
is encoded by: hsa:117247
initial concentration: NaN
has only substance units: false
constant: false
is: Q8TF71
initial amount: NaN

metaR r0119
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:11278832,PMID:4310599 NOTES:
reactant: MODEL1310110025#
name: Guanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
reversible: false
fast: false
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/5.1.3.14
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110025#

metaR PRPPS
fast: false
is version of: http://identifiers.org/ec-code/2.7.6.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
reversible: true
product: MODEL1310110025#
reactant: MODEL1310110025#
name: phosphoribosylpyrophosphate synthetase
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_a9739102_e652_4358_8b10_8be30e3b28e7
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2597
type: Species
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is: E7EUT4
name: GAPDH

metaM leuktrF4 e
initial concentration: 1.0
is: CHEBI:27491
boundary condition: false
has only substance units: false
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
is: HMDB06465
is: SBO:0000247
type: Species
constant: false
name: leukotriene F4
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_b84e43ab_9c77_4808_86f2_6d9252511240
type: Species
is encoded by: hsa:10400
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: PEMT
constant: false
boundary condition: true

metaM hco3 c
is: HMDB00595
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
name: Bicarbonate
is: CHEBI:17544
is: C00288
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288

metaM sphgn c
is: CHEBI:57817
initial amount: NaN
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
type: Species
is: SBO:0000247
boundary condition: false
constant: false
name: sphinganine(1+)
has only substance units: false
is: HMDB00269
initial concentration: 1.0

metaM lnlncg l
constant: false
is: CHEBI:32391
type: Species
has only substance units: false
is: HMDB03073
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: gamma-linolenate

metaR NOt
reversible: true
type: Reaction
kinetic law: MODEL1310110025#
is described by: ECO:0000000
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
name: NO transport (diffusion)
product: MODEL1310110025#
fast: false
is: SBO:0000185

metaR r0196
fast: false
reactant: MODEL1310110025#
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
kinetic law: MODEL1310110025#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.5
type: Reaction
reversible: true
is described by: ECO:0000000
product: MODEL1310110025#
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:

metaR DHAPtc
product: MODEL1310110025#
is described by: ECO:0000134
type: Reaction
fast: false
reversible: false
name: transport of DHAP into cytosol
reactant: MODEL1310110025#
is: SBO:0000185
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaM galside hs e
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
name: D-galactosyl-N-acylsphingosine
is: CHEBI:12947
constant: false
boundary condition: false
has only substance units: false

metaR r1587
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110025#
reactant: MODEL1310110025#
fast: false
kinetic law: MODEL1310110025#

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

metaR r1648
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110025#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
product: MODEL1310110025#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110025#_16cafddf_7513_49b3_8c48_6fb2b004c2fc
initial amount: NaN
name: NDUFA1
has only substance units: false
boundary condition: true
type: Species
is: Q6IBB5
is encoded by: hsa:4694
is: SBO:0000252
constant: false
initial concentration: NaN

metaR FRDPtc
reversible: true
name: lipid, flip-flop intracellular transport
product: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
reactant: MODEL1310110025#
is described by: ECO:0000000
fast: false
is: SBO:0000185
kinetic law: MODEL1310110025#

metaR SUCCtp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
is: SBO:0000185
reversible: true
product: MODEL1310110025#
kinetic law: MODEL1310110025#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110025#
name: succinate transporter, peroxisome
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_67958e43_6e4b_40e3_b726_865ac03ca4e5
name: MPST
constant: false
type: Species
is encoded by: hsa:4357
is: P25325
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR LNLNCGt
name: fatty acid transport via diffusion
is: SBO:0000185
reactant: MODEL1310110025#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110025#
reversible: true
kinetic law: MODEL1310110025#
is described by: ECO:0000000

metaM h2o2 e
constant: false
is: CHEBI:16240
initial concentration: 1.0
name: hydrogen peroxide
type: Species
has only substance units: false
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: HMDB03125
is: SBO:0000247
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110025#_cd29f4f7_a488_480c_8bc0_46a9f06d6ccd
constant: false
name: SDS
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10993
type: Species
is: P20132

http://identifiers.org/biomodels.db/MODEL1310110025#_23682022_40e9_465f_be9c_c732b580fe8e
boundary condition: true
constant: false
initial concentration: NaN
is: B3KUK6
has only substance units: false
is: SBO:0000252
name: NT5C1B
initial amount: NaN
type: Species
is encoded by: hsa:93034

metaM 3hmbcoa m
initial amount: NaN
type: Species
is: CHEBI:57312
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
is: HMDB01356
has only substance units: false
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false

metaM lys L x
constant: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: HMDB00182
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:32551
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: L-lysinium(1+)

metaM taur c
is: HMDB00251
has only substance units: false
boundary condition: false
is: C00245
type: Species
constant: false
name: Taurine
initial concentration: 1.0
notes: FORMULA: C2H7NO3S CHARGE: 0
is: CHEBI:3544
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_b44b76f6_ce1e_4e3d_90de_8466d4b8090b
boundary condition: true
is: Q9H2X9
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:57468
constant: false
type: Species
name: SLC12A5

metaR r1586
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110025#
reversible: true
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_1586d50b_41c0_4fd2_ad8c_b840a7d093bc
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:200010
has only substance units: false
is: E9PAK4
initial amount: NaN
name: SLC5A9

http://identifiers.org/biomodels.db/MODEL1310110025#_90f5c148_3a28_450f_9cfc_4a41526f5022
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
is: Q99798
is encoded by: hsa:50
constant: false
name: ACO2

metaM h2o2 x
initial concentration: 1.0
is: HMDB03125
is: SBO:0000247
name: Hydrogen peroxide
constant: false
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
initial amount: NaN
is: CHEBI:16240
boundary condition: false
type: Species
has only substance units: false
is: C00027

metaR r0909
name: Transport reaction
reactant: MODEL1310110025#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110025#
reversible: true
product: MODEL1310110025#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110025#_2095b575_eaa6_4c71_b41f_66197b64c03d
is: B4DUG1
initial amount: NaN
is encoded by: hsa:9187
type: Species
boundary condition: true
name: SLC24A1
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaM arach e
is: SBO:0000247
type: Species
name: arachidate
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
constant: false
boundary condition: false
is: CHEBI:32360
has only substance units: false
is: HMDB02212

http://identifiers.org/biomodels.db/MODEL1310110025#_3321353c_ea4c_4ecc_a101_7be554ad1d43
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: Q59F77
type: Species
constant: false
has only substance units: false
name: PLCB2
boundary condition: true
is encoded by: hsa:5330

metaR GGH 5THFe
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
type: Reaction
fast: false
modifier: MODEL1310110025#
name: Gamma-glutamyl hydrolase (5THF), extracellular
is described by: ECO:0000000
is: SBO:0000176
reversible: false
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/3.4.19.9
product: MODEL1310110025#

metaM HC01842 c
initial amount: NaN
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:31997
has only substance units: false
name: Phosphodimethylethanolamine

metaR r1588
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110025#
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction

metaR r2096
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reversible: true
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110025#
reactant: MODEL1310110025#
product: MODEL1310110025#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r1292
name: Postulated transport reaction
reactant: MODEL1310110025#
fast: false
kinetic law: MODEL1310110025#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
product: MODEL1310110025#
is described by: ECO:0000000
type: Reaction

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_f209cd28_7a11_4ab1_9c9a_3ba477513c0b
is: SBO:0000252
type: Species
name: FASN
initial amount: NaN
is encoded by: hsa:2194
boundary condition: true
constant: false
initial concentration: NaN
is: P49327
has only substance units: false

metaM cdp n
is: HMDB01546
has only substance units: false
type: Species
is: CHEBI:58069
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
name: CDP(3-)
constant: false
initial amount: NaN

metaM biliverd c
is: HMDB01008
type: Species
initial concentration: 1.0
notes: FORMULA: C33H32N4O6 CHARGE: -2 INCHI: InChI=1S/C33H34N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-15,35H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14-,28-15- EHMN_ABBREVIATION: C00500
initial amount: NaN
is: CHEBI:57991
has only substance units: false
name: biliverdin(2-)
constant: false
boundary condition: false
is: SBO:0000247

metaM sucsal m
is: SBO:0000247
boundary condition: false
is: CHEBI:57706
has only substance units: false
initial concentration: 1.0
is: HMDB01259
constant: false
name: Succinic semialdehyde
type: Species
initial amount: NaN
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232

metaR L LACt4r
name: L-lactate reversible transport via sodium symport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
reversible: true
product: MODEL1310110025#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110025#_ecfb887a_7063_40f8_a9eb_d68c8f579c12
is: SBO:0000297
is encoded by: hsa:51227
initial amount: NaN
type: Species
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false

metaM cs b deg2 l
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 2
type: Species
has only substance units: false
notes: FORMULA: C37H54NO41S3 CHARGE: -5
is: HMDB01354
initial amount: NaN
is: CHEBI:57455

metaR FAOXC180
name: Beta oxidation of long chain fatty acid
modifier: MODEL1310110025#
fast: false
kinetic law: MODEL1310110025#
is: SBO:0000176
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (34.1) or (34.1) or (35.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
reactant: MODEL1310110025#
type: Reaction

metaR EX lac D LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-lactate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_4939fb15_b065_4caf_86fc_eea5a85bfc47
is: SBO:0000252
initial amount: NaN
name: SUCLG1
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is: P53597
is encoded by: hsa:8802
constant: false

metaR r0908
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
type: Reaction
reactant: MODEL1310110025#
product: MODEL1310110025#
name: Postulated transport reaction
kinetic law: MODEL1310110025#
reversible: true
fast: false
is: SBO:0000185

metaM dcmp n
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
name: dCMP(2-)
boundary condition: false
has only substance units: false
is: HMDB01202
is: CHEBI:57566
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
is: SBO:0000247

metaR r1589
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110025#
product: MODEL1310110025#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110025#
is: SBO:0000185

metaR r2095
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110025#
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110025#
product: MODEL1310110025#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110025#

metaR GCHOLAte
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
type: Reaction
is described by: ECO:0000000
name: bile acid intracellular transport
product: MODEL1310110025#
fast: false

metaR r0575
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
modifier: MODEL1310110025#
is described by: ECO:0000000
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.48
is: SBO:0000176
reversible: true
fast: false
product: MODEL1310110025#
type: Reaction

metaR r1291
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
fast: false
product: MODEL1310110025#
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
name: Postulated transport reaction
type: Reaction

metaR NTD7
kinetic law: MODEL1310110025#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.5
type: Reaction
name: 5'-nucleotidase (AMP)
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (22978.1) or (93034.2) or (93034.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
product: MODEL1310110025#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110025#_4885faa2_dc06_47ce_8cff_97dc2d0fab26
initial amount: NaN
boundary condition: true
name: FTCD
constant: false
is: O95954
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:10841
type: Species

metaR GTHRDt
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
product: MODEL1310110025#
reactant: MODEL1310110025#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110025#
is described by: ECO:0000000
type: Reaction
reversible: true
name: Glutathione transport into mitochondria

metaM cdp m
is: CHEBI:58069
initial concentration: 1.0
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
name: CDP(3-)
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: HMDB01546
is: SBO:0000247

metaR DNDPt13m
product: MODEL1310110025#
is: SBO:0000185
modifier: MODEL1310110025#
type: Reaction
kinetic law: MODEL1310110025#
is described by: ECO:0000269
fast: false
reversible: false
name: dADP transport via ATP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110025#

metaR DGSNtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:3696164 NOTES:
name: deoyguanosine transport in mitochondria
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reversible: true
reactant: MODEL1310110025#
type: Reaction
is: SBO:0000185

metaM arachdcoa x
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB06523
is: SBO:0000247
boundary condition: false
is: CHEBI:57368
has only substance units: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
type: Species
name: arachidonoyl-CoA(4-)

metaM HC01434 m
name: oxalatosuccinate(3-)
is: SBO:0000247
type: Species
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:58931
boundary condition: false
constant: false

metaM cgly e
name: L-cysteinylglycine
is: SBO:0000247
is: HMDB00078
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
is: CHEBI:4047
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_7c7332e8_ac83_40fd_9c70_028c1b1e4709
initial concentration: NaN
type: Species
constant: false
boundary condition: true
name: SLC4A3
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6508

http://identifiers.org/biomodels.db/MODEL1310110025#_c9d839b2_9be1_4b86_980b_930f32b12880
type: Species
boundary condition: true
constant: false
initial concentration: NaN
name: SLC28A1
initial amount: NaN
has only substance units: false
is encoded by: hsa:9154
is: SBO:0000252
is: Q96PL7

http://identifiers.org/biomodels.db/MODEL1310110025#_11051a1f_41b5_460f_aecc_603a8e18b5df
initial concentration: NaN
constant: false
name: ACSL1
is: SBO:0000252
boundary condition: true
is: P33121
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:2180

metaR NRPPHRtu
is described by: ECO:0000269
fast: false
name: Norepinephrine uniport
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
reactant: MODEL1310110025#
is: SBO:0000185
product: MODEL1310110025#
type: Reaction
reversible: true
modifier: MODEL1310110025#

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

metaR r2098
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110025#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is: SBO:0000185
reactant: MODEL1310110025#
type: Reaction
product: MODEL1310110025#
modifier: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_529e28e2_f12c_48bc_959f_6dbedeefe36a
type: Species
is encoded by: hsa:1892
constant: false
has only substance units: false
boundary condition: true
is: P30084
name: ECHS1
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_e4101c4f_e6e9_4348_93a6_4bfae6327abb
initial amount: NaN
name: PIGC
is encoded by: hsa:5279
is: Q92535
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_aef62499_629c_4594_b6a3_4982d095a2b2
is: B4DK61
is encoded by: hsa:51
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
name: ACOX1
has only substance units: false
type: Species
boundary condition: true

metaR GLYCK2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 2.7.1.31 Confidence Level: 2 AUTHORS: PMID:9038835 NOTES:JLR
name: glycerate kinase
type: Reaction
product: MODEL1310110025#
fast: false
reactant: MODEL1310110025#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110025#

metaM his L c
initial concentration: 1.0
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
name: L-histidine
initial amount: NaN
is: HMDB00177
is: CHEBI:15971
type: Species

metaR THYOXt
is: SBO:0000185
type: Reaction
reactant: MODEL1310110025#
reversible: true
modifier: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (53919.1) or (6579.1) or (28231.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
name: T4 transport via bicarbonate countertransport
kinetic law: MODEL1310110025#
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110025#_d784686d_3438_4547_87d6_476124037143
boundary condition: true
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:4967
has only substance units: false
initial amount: NaN
name: OGDH
is: SBO:0000252
is: Q02218

metaM gam e
is: HMDB01514
constant: false
initial concentration: 1.0
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
is: SBO:0000247
initial amount: NaN
is: CHEBI:17315
has only substance units: false
type: Species
is: C00329
name: D-Glucosamine
boundary condition: false

metaR 34DHOXPEGt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:7473774 NOTES:SAB
is: SBO:0000185
fast: false
kinetic law: MODEL1310110025#
is described by: ECO:0000000
reactant: MODEL1310110025#
reversible: true
product: MODEL1310110025#
type: Reaction
name: 3,4-Dihydroxyphenylethyleneglycol transport (diffusion)

http://identifiers.org/biomodels.db/MODEL1310110025#_1666f7b0_8c6e_4d79_8861_354a4533b8fe
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:113
name: ADCY7
type: Species
initial amount: NaN
constant: false
is: P51828
initial concentration: NaN

metaR MECOAS1m
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/6.2.1.4
type: Reaction
fast: false
reversible: true
is: SBO:0000176
product: MODEL1310110025#
modifier: MODEL1310110025#
is described by: ECO:0000304
name: mesaconate--CoA ligase (GDP-forming)
reactant: MODEL1310110025#

metaR UDPGLCter
reversible: true
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
kinetic law: MODEL1310110025#
is: SBO:0000185
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110025#
fast: false
type: Reaction

metaM ribflv e
initial concentration: 1.0
is: C00255
is: SBO:0000247
is: CHEBI:3554
name: Riboflavin
has only substance units: false
type: Species
notes: FORMULA: C17H20N4O6 CHARGE: 0
initial amount: NaN
boundary condition: false
constant: false
is: HMDB00244

http://identifiers.org/biomodels.db/MODEL1310110025#_7ba1dab4_c421_42f3_8375_5dfd4943af3f
is: O15245
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:6580
name: SLC22A1

metaR r1702
type: Reaction
name: Y+LAT2 Utilized transport
product: MODEL1310110025#
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
modifier: MODEL1310110025#
is described by: ECO:0000000
is: SBO:0000185
reversible: false
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r2097
kinetic law: MODEL1310110025#
fast: false
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reactant: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000000
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction

metaR DMNONCOACRNCPT1
name: DMNONCOACRNCPT1
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110025#
is described by: ECO:0000000
product: MODEL1310110025#
is: SBO:0000176
reactant: MODEL1310110025#

metaR r0573
type: Reaction
kinetic law: MODEL1310110025#
product: MODEL1310110025#
fast: false
name: Cholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
is described by: ECO:0000000
reactant: MODEL1310110025#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:438652 NOTES:
reversible: true

metaR RE1520M
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110025#
product: MODEL1310110025#
fast: false
name: RE1520
kinetic law: MODEL1310110025#
reversible: true
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110025#_29e0efe7_edd1_4f1f_97e1_b5090b4c4b16
boundary condition: true
type: Species
constant: false
is: P00374
is: SBO:0000252
name: DHFR
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:1719

metaR NODe
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110025#
name: NODe
is described by: ECO:0000134
fast: false
product: MODEL1310110025#
kinetic law: MODEL1310110025#
reversible: true
type: Reaction

metaM lys L e
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
name: L-lysinium(1+)
type: Species
has only substance units: false
is: CHEBI:32551
is: HMDB00182
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_7fcc92cf_11e5_4ef9_a86d_9456e97ae90e
is: SBO:0000252
boundary condition: true
is encoded by: hsa:686
name: BTD
initial amount: NaN
has only substance units: false
is: P43251
constant: false
initial concentration: NaN
type: Species

metaM CE5117 m
initial amount: NaN
type: Species
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA
is: SBO:0000247
constant: false
is: CHEBI:12947
initial concentration: 1.0
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110025#_b295c7c4_5983_4503_8c1a_146ad1ac0c2a
is: Q08499
has only substance units: false
initial amount: NaN
is encoded by: hsa:5144
boundary condition: true
name: PDE4D
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false

metaM 5htrp e
is: SBO:0000247
is: HMDB00472
initial concentration: 1.0
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643
is: CHEBI:17780
has only substance units: false
type: Species
boundary condition: false
constant: false
name: 5-hydroxy-L-tryptophan
initial amount: NaN

metaM ha deg1 l
is: CHEBI:16336
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C22H33N2O16 CHARGE: -1
constant: false
is: SBO:0000247
name: hyaluronan degradation product 1
initial concentration: 1.0

metaM dmpp x
is: HMDB01120
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:57623
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h3H,4H2,1-2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00213 EHMN_ABBREVIATION: C00235
type: Species
name: prenyl diphosphate(3-)
has only substance units: false

metaR EX 34hpp
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_163191e9_9e87_4837_9ab9_0d09f4c90255
is encoded by: hsa:AA278423
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
constant: false
name: _AA278423_1_c
boundary condition: true

metaM tststerone r
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
is: CHEBI:17347
initial amount: NaN
has only substance units: false
name: testosterone
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00234
type: Species

metaM e4hglu m
is: HMDB02273
name: erythro-4-hydroxy-L-glutamate(1-)
boundary condition: false
is: CHEBI:6331
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_cd0deaf7_19b2_424c_9908_1b640526ec84
constant: false
has only substance units: false
is: Q96IJ6
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:29926
initial concentration: NaN
boundary condition: true
name: GMPPA

metaR r0578
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/4.1.2.27
reversible: true
product: MODEL1310110025#
modifier: MODEL1310110025#
is described by: ECO:0000000
is: SBO:0000176
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
type: Reaction
fast: false

metaR SR5ARr
kinetic law: MODEL1310110025#
fast: false
name: 3-oxo-5-alpha-steroid 4-dehydrogenase
type: Reaction
reversible: false
reactant: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (6716.1) or (6715.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.99.5 Confidence Level: 4 AUTHORS: PMID:2339109 NOTES:there are actually two types, but the difference between them lies in optimal pH function - grouped as one reaction at his point to eliminate redundancy. NADP known to be cofactor NJ. human 5alpha-HSD activity determined in transfected COS cells using C-14 labelled testosterone as substrate
is: SBO:0000176
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.3.99.5
is described by: ECO:0000134

metaM CE2432 m
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
type: Species
is: http://identifiers.org/pubchem.compound/5041
has only substance units: false
is: C01936
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN

metaR EX psyl LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for psyllium
type: Reaction

metaM gtp c
initial concentration: 1.0
name: GTP
boundary condition: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: C00044
is: HMDB01273
is: CHEBI:37565
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247

metaR r1799
is described by: ECO:0000000
reactant: MODEL1310110025#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110025#
product: MODEL1310110025#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110025#

metaR H2Otm
reactant: MODEL1310110025#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110025#
reversible: true
product: MODEL1310110025#
modifier: MODEL1310110025#
name: H2O transport, mitochondrial
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110025#_c0b207e3_6ecf_40b2_a3f7_250f5634d598
is: O95497
initial amount: NaN
boundary condition: true
constant: false
name: VNN1
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:8876

metaR FAOXC80
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TDV (9/7/2004) Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is: SBO:0000176
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110025#
type: Reaction
name: Beta oxidation of med/long chain fatty acid
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_8f17f30a_abb8_4561_9522_38fb2d79bf2f
boundary condition: true
initial concentration: NaN
constant: false
name: ACSL5
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:51703
is: Q9ULC5

metaR KCCt
modifier: MODEL1310110025#
fast: false
type: Reaction
reactant: MODEL1310110025#
is described by: ECO:0000269
product: MODEL1310110025#
name: K+-Cl- cotransport
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD
kinetic law: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_5872c1a9_e1c2_4a79_ad90_32c2758f10f1
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:10599
boundary condition: true
type: Species
has only substance units: false
is: Q9Y6L6
name: SLCO1B1

metaM gam c
boundary condition: false
is: CHEBI:17315
initial amount: NaN
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
type: Species
is: C00329
is: HMDB01514
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: D-Glucosamine

metaM glcur l
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
name: D-glucuronate
is: HMDB00127
is: SBO:0000247
is: CHEBI:15748

metaR r2099
type: Reaction
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
product: MODEL1310110025#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
modifier: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
is: SBO:0000185

metaR AHCYSte
product: MODEL1310110025#
name: Transport of S-adenosyl-L-homocysteine
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000185
reactant: MODEL1310110025#

metaM apoC Lys btn c
has only substance units: false
is: HMDB00182
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
is: CHEBI:32551
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C16H27N4O3SX CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110025#_55b3c002_b5c4_4e71_b06e_acdd352f92da
boundary condition: true
type: Species
name: MPI
initial concentration: NaN
is: P34949
constant: false
is encoded by: hsa:4351
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR r1798
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reversible: false
fast: false
reactant: MODEL1310110025#
product: MODEL1310110025#
modifier: MODEL1310110025#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_12b43883_5ed4_4bd3_8406_c02c9f4520a1
is: SBO:0000252
boundary condition: true
is encoded by: hsa:R33828
initial concentration: NaN
constant: false
initial amount: NaN
name: _R33828_1_c
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_2e77bf51_6f5d_4cc4_b3de_e78da2f1ebaf
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
name: _AA502753_1_m
initial concentration: NaN
is encoded by: hsa:AA502753

http://identifiers.org/biomodels.db/MODEL1310110025#_ccda1205_ed9f_40cd_9278_0ba0ec742a4a
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: P22304
name: IDS
type: Species
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:3423

http://identifiers.org/biomodels.db/MODEL1310110025#_6c86dd72_d4cd_4dfc_8278_ad8f7f8fa41b
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:LOC374569
boundary condition: true
is: SBO:0000252
name: _LOC374569_1_e
type: Species

metaM 2pg c
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: 1/C3H7O7P/c4-1-2(3(5)6)10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/t2-/m1/s1/f/h5,7-8H HEPATONET_1.0_ABBREVIATION: HC00463 EHMN_ABBREVIATION: C00631
name: D-Glycerate 2-phosphate
boundary condition: false
initial amount: NaN
is: CHEBI:58289
is: SBO:0000247
type: Species
is: HMDB03391
is: C00631
initial concentration: 1.0
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/3904

metaR r0579
modifier: MODEL1310110025#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110025#
is: SBO:0000176
reactant: MODEL1310110025#
type: Reaction
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.13.11.19
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
reversible: true
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33

metaR H2Otn
is described by: ECO:0000000
name: H2O transport, nuclear
reactant: MODEL1310110025#
reversible: true
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110025#

metaM lys L c
initial amount: NaN
is: CHEBI:32551
has only substance units: false
constant: false
initial concentration: 1.0
name: L-lysinium(1+)
boundary condition: false
is: SBO:0000247
is: HMDB00182
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
type: Species

metaR UAG2EMAi
product: MODEL1310110025#
kinetic law: MODEL1310110025#
reversible: false
fast: false
is: SBO:0000176
reactant: MODEL1310110025#
is described by: ECO:0000269
name: UDP-N-acetyl-D-glucosamine 2-epimerase (Hydrolysis)
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835 NOTES:
type: Reaction
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/5.1.3.14

metaM prostge1 c
initial amount: NaN
name: prostaglandin E1(1-)
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
is: CHEBI:57397
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
is: HMDB01442
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110025#_4736434c_8d7c_480d_94e7_cccbfd4ec124
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: Q96G03
has only substance units: false
name: PGM2
boundary condition: true
constant: false
is encoded by: hsa:55276
type: Species

metaR ARACHt
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
reversible: true
is: SBO:0000185
reactant: MODEL1310110025#
is described by: ECO:0000000
product: MODEL1310110025#
type: Reaction
fast: false

metaR LEUtec
is: SBO:0000185
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
fast: false
kinetic law: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000269
reversible: true
name: L-leucine transport via diffusion (extracellular to cytosol)
reactant: MODEL1310110025#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_8edd5af8_c413_419c_b944_d4545e401b63
is: SBO:0000252
boundary condition: true
name: AK3
is: E7ET30
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:50808

metaM arach c
initial concentration: 1.0
is: SBO:0000247
name: arachidate
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
is: CHEBI:32360
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
is: HMDB02212
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_a71a84d5_1312_486d_bd44_be06095917c0
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
is: Q16678
is encoded by: hsa:1545
name: CYP1B1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_a1025991_879a_4cf1_9280_8bb8649fbbcd
boundary condition: true
initial concentration: NaN
is encoded by: hsa:285973
is: Q674R7
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
name: ATG9B
constant: false

metaR r0801
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110025#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
is: SBO:0000185
reversible: true
product: MODEL1310110025#
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
fast: false

metaM gtp e
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:37565
has only substance units: false
initial amount: NaN
is: HMDB01273
name: GTP(4-)
boundary condition: false
constant: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044

metaR DOPABMO
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.17.1
reactant: MODEL1310110025#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (26002.1) or (1621.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.14.17.1 Confidence Level: 4 AUTHORS: NOTES:SAB
modifier: MODEL1310110025#
reversible: false
product: MODEL1310110025#
name: dopamine beta-monooxygenase
fast: false

metaR IDOAASE4ly
reversible: false
name: alpha-L-iduronidase, lysosomal
is described by: ECO:0000000
reactant: MODEL1310110025#
modifier: MODEL1310110025#
fast: false
product: MODEL1310110025#
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/3.2.1.76
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110025#_00d26eca_25a1_4ec4_800e_e89fbfe18e40
is encoded by: hsa:8867
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
is: C9JFZ1
name: SYNJ1

metaR r0340
modifier: MODEL1310110025#
is described by: ECO:0000000
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
is: SBO:0000176
reversible: false
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.3.1.38
fast: false
type: Reaction
reactant: MODEL1310110025#
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31

metaR DALAt2r
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
fast: false
reactant: MODEL1310110025#
modifier: MODEL1310110025#
type: Reaction
reversible: true
product: MODEL1310110025#
name: D-alanine transport via proton symport
kinetic law: MODEL1310110025#
is: SBO:0000185
is described by: ECO:0000304

metaR RE3006M
reactant: MODEL1310110025#
is described by: ECO:0000000
reversible: true
name: RE3006
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
type: Reaction
fast: false
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110025#
product: MODEL1310110025#

metaR CDSm
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.41
notes: GENE_ASSOCIATION: (8760.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:inner mitochondrial membrane NJ
reversible: false
fast: false
is described by: ECO:0000000
product: MODEL1310110025#
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
is: SBO:0000176
name: phosphatidate cytidylyltransferase
reactant: MODEL1310110025#

metaR FADH2ETC
product: MODEL1310110025#
type: Reaction
kinetic law: MODEL1310110025#
is described by: ECO:0000134
is: SBO:0000176
name: Complex II reaction for respiratory chain
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: false
fast: false
reactant: MODEL1310110025#

metaR 2HBt2
fast: false
name: 2-hydroxybutyrate cotransport with proton
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
modifier: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_c5fa0ad0_1643_4735_8b91_5cd028dabaac
initial concentration: NaN
name: UCK1
type: Species
initial amount: NaN
is encoded by: hsa:83549
boundary condition: true
is: SBO:0000252
is: Q5JT09
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_6b3cfc38_43e9_415f_b4f3_4932413d4ce0
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:51
name: ACOX1
initial amount: NaN
is: SBO:0000252
is: B4DK61
constant: false
boundary condition: true

metaR SPHS1Pte
is: SBO:0000185
name: sphingosine-1-phosphate transport
reactant: MODEL1310110025#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110025#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ
product: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_fe50d741_76e5_4c5e_8df7_d6824edfbd6b
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:AI620219
name: _AI620219_1_m
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_0f99f734_3fb1_4e34_ab24_97e1c77e21d9
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
name: PMVK
is: Q6FGV9
is encoded by: hsa:10654
initial amount: NaN

metaM 5dpmev c
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
name: (R)-5-Diphosphomevalonate
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1
is: HMDB01090

metaR RE2660C
product: MODEL1310110025#
is: SBO:0000176
reactant: MODEL1310110025#
is described by: ECO:0000000
kinetic law: MODEL1310110025#
reversible: true
type: Reaction
name: RE2660
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
fast: false

metaR EX acmana LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-acetyl-D-mannosamine
type: Reaction

metaR CYTK1
reactant: MODEL1310110025#
name: cytidylate kinase (CMP)
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110025#
product: MODEL1310110025#
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
type: Reaction

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_e593f4a3_a0c2_4b2a_9a54_13265cf06d9d
constant: false
name: AICDA
initial amount: NaN
type: Species
is encoded by: hsa:57379
has only substance units: false
is: SBO:0000252
boundary condition: true
is: Q546Y9
initial concentration: NaN

metaR r0791
reactant: MODEL1310110025#
modifier: MODEL1310110025#
is described by: ECO:0000000
fast: false
is: SBO:0000176
kinetic law: MODEL1310110025#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
product: MODEL1310110025#

metaR DOPAtu
fast: false
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
is: SBO:0000185
reversible: true
reactant: MODEL1310110025#
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
name: Dopamine uniport
product: MODEL1310110025#

metaM prostge1 e
is: HMDB01442
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
initial amount: NaN
is: CHEBI:57397
name: prostaglandin E1(1-)
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false

metaR r2100
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110025#
fast: false
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r2326
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110025#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaM pnto R e
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
name: (R)-Pantothenate
boundary condition: false
is: HMDB00210
is: CHEBI:7916
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
type: Species

metaR RE1342C
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
name: RE1342
fast: false
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
reversible: true
is described by: ECO:0000000
product: MODEL1310110025#

metaM 3hbcoa m
name: (S)-3-hydroxybutanoyl-CoA(4-)
constant: false
is: SBO:0000247
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
is: HMDB01166
type: Species
initial concentration: 1.0
is: CHEBI:57316
initial amount: NaN
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110025#_a7069075_068d_442d_8529_a4c781d47527
is encoded by: hsa:65010
is: SBO:0000252
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is: Q9Y3Y1
boundary condition: true
name: SLC26A6
initial amount: NaN

metaR r2327
is: SBO:0000185
kinetic law: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
reactant: MODEL1310110025#
is described by: ECO:0000000
product: MODEL1310110025#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

http://identifiers.org/biomodels.db/MODEL1310110025#_6f28fb0a_02b7_4edc_9255_420619786e66
boundary condition: true
constant: false
is encoded by: hsa:84569
is: SBO:0000252
has only substance units: false
name: LYZL1
initial amount: NaN
initial concentration: NaN
is: Q6UWQ5
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_40a177c7_bd54_4c38_88e7_2e24d3227cbb
is: Q9H6R3
boundary condition: true
has only substance units: false
is encoded by: hsa:79611
type: Species
is: SBO:0000252
name: ACSS3
initial concentration: NaN
constant: false
initial amount: NaN

metaR r0688
reactant: MODEL1310110025#
modifier: MODEL1310110025#
is described by: ECO:0000000
product: MODEL1310110025#
reversible: true
is: SBO:0000176
type: Reaction
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
fast: false
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_fd70bd4c_7576_42e9_8af9_68f8aaf38731
is encoded by: hsa:4023
name: LPL
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
is: P06858
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_622e6038_0cc8_45e2_b533_5393cdbea928
is encoded by: hsa:80308
is: SBO:0000252
initial concentration: NaN
name: FLAD1
type: Species
is: Q8NFF5
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true

metaM ascb L e
name: L-ascorbate
constant: false
is: CHEBI:38290
type: Species
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB00044
initial amount: NaN

metaR CYTK2
modifier: MODEL1310110025#
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
name: cytidylate kinase (dCMP)
is described by: ECO:0000269
product: MODEL1310110025#
kinetic law: MODEL1310110025#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
reversible: true

metaR SGPL12r
reactant: MODEL1310110025#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ
product: MODEL1310110025#
is: SBO:0000176
is described by: ECO:0000304
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
name: Sphingosine-1-phosphate lyase
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.2.27

http://identifiers.org/biomodels.db/MODEL1310110025#_65eb506d_278f_4aa2_af22_88e96eb1c11c
initial concentration: NaN
is: P30519
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
name: HMOX2
type: Species
is encoded by: hsa:3163

http://identifiers.org/biomodels.db/MODEL1310110025#_160c234c_a7ed_418a_a4a9_20352c34b55c
is: SBO:0000252
name: PLCG2
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:5336
constant: false
has only substance units: false
initial amount: NaN
is: P16885

metaM dsT antigen g
constant: false
is: CHEBI:16497
initial concentration: 1.0
notes: FORMULA: C36H56N3O26X CHARGE: -2
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB01440
name: disialyl-T antigen
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_79d05091_5c83_4a6d_89cb_9057e27b5ad8
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: UGT1A8
constant: false
boundary condition: true
is encoded by: hsa:54576
initial amount: NaN
is: Q5DSZ6

http://identifiers.org/biomodels.db/MODEL1310110025#_9e97ba2d_1009_4268_9c83_629b7d3bc8eb
name: SCP2
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6342
is: C9JC79
initial amount: NaN
type: Species

metaR EX leuktrA4 LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene A4 exchange
type: Reaction

metaR r2101
reversible: true
kinetic law: MODEL1310110025#
product: MODEL1310110025#
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110025#

metaM cdp e
is: CHEBI:58069
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
initial amount: NaN
name: CDP(3-)
is: HMDB01546
is: SBO:0000247
constant: false
has only substance units: false
type: Species

metaM retinol cis 11 c
is: HMDB06216
boundary condition: false
is: CHEBI:16302
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
name: 11-cis-retinol

metaR r2328
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
kinetic law: MODEL1310110025#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110025#
fast: false
type: Reaction
product: MODEL1310110025#

metaR CYTK3
is: SBO:0000176
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.3
name: cytidylate kinase (CMP)(GTP)
product: MODEL1310110025#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#

metaR LEUKTRA4t
fast: false
is: SBO:0000185
product: MODEL1310110025#
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:
type: Reaction
name: leukotriene A4 transport
reversible: true
reactant: MODEL1310110025#
is described by: ECO:0000269

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

metaM HC00460 c
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
constant: false
is: CHEBI:58044
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
name: 2,5-dihydroxybenzoate
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110025#_0ea28758_8df2_4b3b_a3d3_22ae166d33d0
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:376497
is: Q6PCB7
has only substance units: false
name: SLC27A1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110025#_b54b7d83_82a5_4586_bdf0_9b80b14812a8
name: LDHB
is encoded by: hsa:3945
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
is: P07195
initial concentration: NaN
has only substance units: false
type: Species

metaM bilirub r
has only substance units: false
initial concentration: 1.0
is: CHEBI:57977
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
is: HMDB00054
is: SBO:0000247
name: bilirubin(2-)
boundary condition: false
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_a6149759_6a13_49b7_98e2_05c6fea22d9c
type: Species
name: BLVRA
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: P53004
boundary condition: true
is: SBO:0000252
is encoded by: hsa:644
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_504a5ae7_a124_4d38_8cc9_8a1cede40ca7
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
name: CMA1
is: Q4FEB3
initial amount: NaN
is encoded by: hsa:1215

metaR r2102
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
type: Reaction
product: MODEL1310110025#
kinetic law: MODEL1310110025#
fast: false
modifier: MODEL1310110025#
reversible: true
is: SBO:0000185

metaM pnto R c
has only substance units: false
name: (R)-Pantothenate
initial amount: NaN
is: HMDB00210
is: CHEBI:7916
constant: false
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568

metaR r0450
kinetic law: MODEL1310110025#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
product: MODEL1310110025#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.3
fast: false
modifier: MODEL1310110025#
is described by: ECO:0000000
reactant: MODEL1310110025#

metaR CSNt
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
type: Reaction
product: MODEL1310110025#
modifier: MODEL1310110025#
is described by: ECO:0000269
reversible: true
name: cytosine transport via facilated diffusion
is: SBO:0000185
reactant: MODEL1310110025#
fast: false

metaR EX 11 cis retfa LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid 11-cis-retinol exchange
type: Reaction

metaM btn c
is: C00120
notes: FORMULA: C10H15N2O3S CHARGE: -1
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:3420
has only substance units: false
is: HMDB00030
type: Species
name: Biotin

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

metaR r2329
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110025#
is: SBO:0000185
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110025#_ee595b90_ee67_49a7_b394_7bdf5fbb8afd
initial concentration: NaN
type: Species
is: P15848
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:411
name: ARSB
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110025#_7fe11c58_0f72_4ff1_9470_e81f6552f5cc
initial concentration: NaN
is: SBO:0000252
is: A0PJJ9
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:2686
constant: false
boundary condition: true
name: GGT7

metaR RETNt
product: MODEL1310110025#
reactant: MODEL1310110025#
name: retinoic acid transport
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110025#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
reversible: true

metaR H2Otp
fast: false
product: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000000
kinetic law: MODEL1310110025#
name: H2O transport, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
type: Reaction
reversible: true

metaR ABTD
is: SBO:0000176
reactant: MODEL1310110025#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
fast: false
name: L-arabinitol 4-dehydrogenase
reversible: true
product: MODEL1310110025#
type: Reaction
kinetic law: MODEL1310110025#

metaR ASCBt4
reversible: true
kinetic law: MODEL1310110025#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
type: Reaction
is described by: ECO:0000269
product: MODEL1310110025#
reactant: MODEL1310110025#
name: L-ascorbate transport via proton symport
modifier: MODEL1310110025#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110025#_b5cde20a_483e_45da_b60b_c2e2d348a967
initial concentration: NaN
is: Q9NS82
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:56301
name: SLC7A10
constant: false
type: Species

metaR GLNS
product: MODEL1310110025#
reversible: false
type: Reaction
is described by: ECO:0000254
modifier: MODEL1310110025#
name: glutamine synthetase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.15
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false

metaM ascb L c
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
initial amount: NaN
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:38290
boundary condition: false
is: SBO:0000247
name: L-ascorbate
is: HMDB00044

metaR CYTK4
kinetic law: MODEL1310110025#
reversible: true
reactant: MODEL1310110025#
name: cytidylate kinase (dCMP)(GTP)
type: Reaction
modifier: MODEL1310110025#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.3
is: SBO:0000176
product: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:

metaR H2O2tp
type: Reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
fast: false
name: hydrogen peroxide peroxisomal transport via diffusion
is: SBO:0000185
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reactant: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_b51b7d22_494a_4a7b_a024_a194d8b1d00d
name: SLC5A5
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:6528
is: SBO:0000252
type: Species
is: Q92911

metaR r0686
reactant: MODEL1310110025#
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
modifier: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.2.2
is: SBO:0000176
product: MODEL1310110025#
type: Reaction
kinetic law: MODEL1310110025#
reversible: true

metaM cdp c
is: C00112
initial concentration: 1.0
name: CDP
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
has only substance units: false
is: CHEBI:58069
constant: false
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB01546

http://identifiers.org/biomodels.db/MODEL1310110025#_dea116f3_1e94_47e0_b5e8_aeb9ce0fe867
boundary condition: true
is: SBO:0000252
name: _AI640625_1_c
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:AI640625
type: Species
has only substance units: false

metaR CYTK5
name: cytidylate kinase (dCMP)
product: MODEL1310110025#
reversible: true
reactant: MODEL1310110025#
is described by: ECO:0000269
modifier: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
kinetic law: MODEL1310110025#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14

http://identifiers.org/biomodels.db/MODEL1310110025#_d5aa161d_3e44_476a_ab72_b9a6b46ffde7
is: Q6IBC0
boundary condition: true
name: HMGCL
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3155
has only substance units: false
type: Species
constant: false
initial amount: NaN

metaR r2103
kinetic law: MODEL1310110025#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
product: MODEL1310110025#
reactant: MODEL1310110025#

metaM retinol cis 11 e
initial amount: NaN
boundary condition: false
is: CHEBI:16302
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
has only substance units: false
initial concentration: 1.0
name: 11-cis-retinol
is: HMDB06216

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

metaR r0002
type: Reaction
product: MODEL1310110025#
is described by: ECO:0000000
reversible: true
name: Active transport
is: SBO:0000185
fast: false
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
reactant: MODEL1310110025#

metaM lys L m
constant: false
is: SBO:0000247
name: L-lysinium(1+)
boundary condition: false
initial concentration: 1.0
is: CHEBI:32551
is: HMDB00182
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047

http://identifiers.org/biomodels.db/MODEL1310110025#_317185a1_9e4c_4c34_bb2b_0504496f211f
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4128
is: Q53YE7
initial concentration: NaN
constant: false
has only substance units: false
type: Species
name: MAOA
boundary condition: true

metaM ribflv c
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:3554
notes: FORMULA: C17H20N4O6 CHARGE: 0
name: Riboflavin
constant: false
is: SBO:0000247
is: C00255
initial concentration: 1.0
is: HMDB00244
boundary condition: false

metaR RE0944E
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
type: Reaction
product: MODEL1310110025#
name: RE0944
is described by: ECO:0000000
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.17
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.1
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110025#_cb435127_3426_45d5_9876_d6fdcd2e2178
name: ALAS2
is: Q5JZF5
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:212
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN

metaR FTCD
is: SBO:0000176
type: Reaction
reactant: MODEL1310110025#
name: formimidoyltransferase cyclodeaminase
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Folate metabolism EC Number: 4.3.1.4 Confidence Level: 4 AUTHORS: PMID:14697341 NOTES:IT
product: MODEL1310110025#
kinetic law: MODEL1310110025#
fast: false
is described by: ECO:0000134
reversible: false
is version of: http://identifiers.org/ec-code/2.1.2.5
modifier: MODEL1310110025#

metaR C4STMO1r
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.72
type: Reaction
notes: GENE_ASSOCIATION: (6307.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:EC 1.-.-.- NCD ER version NJ
modifier: MODEL1310110025#
name: C-4 sterol methyl oxidase (4,4-dimethylzymosterol)
reactant: MODEL1310110025#
product: MODEL1310110025#
is: SBO:0000176
kinetic law: MODEL1310110025#
fast: false

metaM pheacgln c
is: HMDB06344
type: Species
is: CHEBI:58310
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
constant: false
initial amount: NaN
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate

metaR SERDGLNexR
is described by: ECO:0000304
reversible: true
name: D-Serine/Glutamine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
fast: false
reactant: MODEL1310110025#
type: Reaction
product: MODEL1310110025#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110025#_72a12c1e_d2c4_48b2_b515_25f5b3a672ec
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
type: Species
is: P19404
is encoded by: hsa:4729
name: NDUFV2
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_f7670673_e0bf_494a_98de_a74f4cbfc333
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: PIGO
type: Species
constant: false
is encoded by: hsa:84720
is: SBO:0000252

metaR r2104
product: MODEL1310110025#
modifier: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110025#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false

metaR SCP22x
product: MODEL1310110025#
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.3.1.176
modifier: MODEL1310110025#
name: Sterol carrier protein 2
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
kinetic law: MODEL1310110025#

metaR PSSA2 hs
reactant: MODEL1310110025#
name: Phosphatidylserine synthase homo sapiens
kinetic law: MODEL1310110025#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.8.29
product: MODEL1310110025#
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (81490.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylethanolamine version as substrate NJ
is described by: ECO:0000269
is: SBO:0000176
reversible: true

metaR r2092
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110025#
kinetic law: MODEL1310110025#
is: SBO:0000185
modifier: MODEL1310110025#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
reactant: MODEL1310110025#
type: Reaction

metaR FAOXC200180m
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of long chain fatty acid
is: SBO:0000176
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
modifier: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000000
type: Reaction

metaR r1431
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
is described by: ECO:0000000
product: MODEL1310110025#
reversible: false
fast: false
type: Reaction
name: 2-Deoxyuridine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Pyrimidine metabolism EC:1.17.4.1
reactant: MODEL1310110025#
is: SBO:0000176
kinetic law: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_ca795741_1207_4ff6_9082_3a252379de7f
is encoded by: hsa:171425
type: Species
initial amount: NaN
has only substance units: false
name: CLYBL
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true

metaR r0683
product: MODEL1310110025#
kinetic law: MODEL1310110025#
is described by: ECO:0000000
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
fast: false
reactant: MODEL1310110025#
is: SBO:0000176
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110025#_c01736cf_47c3_4f54_8460_05398d663c57
is encoded by: hsa:5138
initial concentration: NaN
boundary condition: true
name: PDE2A
constant: false
is: Q8IW54
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN

metaR CYTK6
modifier: MODEL1310110025#
name: cytidylate kinase (CMP,CTP)
is described by: ECO:0000269
product: MODEL1310110025#
type: Reaction
reactant: MODEL1310110025#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110025#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true

metaM HC01406 m
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:28264
name: 3-Oxooctanoyl-CoA
constant: false

metaM his L e
name: L-histidine
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00177
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:15971

metaM sphings c
is: HMDB00252
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: sphingosine(1+)
is: CHEBI:57756
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_576de72f_17b8_4a51_9c21_904da236ad6b
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000297
has part: P00325
is encoded by: hsa:125
constant: false
name: ADH1A:ADH1B
is encoded by: hsa:124
has part: P07327
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_76d4219a_9813_4a3e_a18d_db64e77ca773
is: SBO:0000252
is encoded by: hsa:51166
boundary condition: true
is: Q8N5Z0
type: Species
name: AADAT
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaR ALAGLYexR
name: L-alanine/glycine reversible exchange
fast: false
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
product: MODEL1310110025#
type: Reaction
reversible: true
is: SBO:0000185

metaR GLYt2r
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
type: Reaction
product: MODEL1310110025#
reactant: MODEL1310110025#
name: glycine reversible transport via proton symport
modifier: MODEL1310110025#
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000304

metaR r2090
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reactant: MODEL1310110025#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110025#
product: MODEL1310110025#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110025#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110025#_d6c5040e_1c3a_4044_9a8a_947700fe7ac2
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
is: P42765
is: SBO:0000252
name: ACAA2
is encoded by: hsa:10449
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_463c0800_0230_4a6f_b9cf_4f5d08a12a3e
type: Species
is: SBO:0000252
is: F5H066
is encoded by: hsa:6560
boundary condition: true
constant: false
name: SLC12A4
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaM btn e
is: HMDB00030
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: Biotin
is: C00120
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H15N2O3S CHARGE: -1
constant: false
is: CHEBI:3420

http://identifiers.org/biomodels.db/MODEL1310110025#_b495b0c5_14a1_408e_8586_9781e3b6cc01
is encoded by: hsa:80201
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: B3KT70
type: Species
name: HKDC1

metaR OCCOAtx
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
fast: false
is: SBO:0000185
kinetic law: MODEL1310110025#
reversible: true
product: MODEL1310110025#
name: fatty acid intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110025#_56eafaf0_d7e3_4322_a052_73f0752a4bed
is encoded by: hsa:D87002
name: _D87002_1_m
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_b788583f_ac63_4f49_a47e_b7948d9ce0af
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:53354
is: Q8TE04
name: PANK1
constant: false
type: Species
initial amount: NaN

metaR EX btn LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biotin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_29f5abfc_3999_43ba_a2fa_81e9ec0542b8
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6569
is: Q7Z725
name: SLC34A1
type: Species

metaR r2105
product: MODEL1310110025#
kinetic law: MODEL1310110025#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reversible: true
reactant: MODEL1310110025#

metaM dolp L r
initial amount: NaN
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
is: SBO:0000247
name: dolichyl phosphate(2-)
has only substance units: false
boundary condition: false
is: CHEBI:57683
type: Species
constant: false
initial concentration: 1.0

metaR S4TASE3ly
kinetic law: MODEL1310110025#
fast: false
reversible: true
reactant: MODEL1310110025#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.12
is described by: ECO:0000000
modifier: MODEL1310110025#
name: N-acetylgalactosamine-4-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
type: Reaction
product: MODEL1310110025#

metaR CYTK7
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110025#
reactant: MODEL1310110025#
product: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110025#
name: cytidylate kinase (CMP,UTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110025#_f002d084_bde0_4811_ab00_9293b96d8d3b
constant: false
name: _AI348006_1_c
is encoded by: hsa:AI348006
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR r2091
product: MODEL1310110025#
reversible: true
type: Reaction
kinetic law: MODEL1310110025#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110025#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110025#_ce82984a_48be_4886_a9f5_d7c1f059e073
name: _AA021081_1_r
boundary condition: true
type: Species
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:AA021081
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_1b754f9b_1bda_40c5_a35b_3157eb434139
boundary condition: true
is encoded by: hsa:1607
type: Species
has only substance units: false
name: DGKB
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
is: Q9Y6T7

http://identifiers.org/biomodels.db/MODEL1310110025#_f3f5544a_73c8_4981_b311_83ecbd62099c
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1716
constant: false
name: DGUOK
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_f1b45170_4f91_45e1_bf1d_25297c68c508
initial amount: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:1103
name: CHAT
has only substance units: false
initial concentration: NaN
is: Q6LEN6

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

metaR MECOALm
is described by: ECO:0000212
modifier: MODEL1310110025#
type: Reaction
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/6.2.1.4
product: MODEL1310110025#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.5
is: SBO:0000176
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD

metaM clpn hs c
is: CHEBI:28494
has only substance units: false
type: Species
notes: FORMULA: C9H16O9P2FULLRCO2FULLR2CO2FULLRCO2FULLR2CO2 CHARGE: -2
initial amount: NaN
initial concentration: 1.0
name: cardiolipin
boundary condition: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110025#_66eb9f9d_b99e_4b7e_866b_deff09115171
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:50
has only substance units: false
initial amount: NaN
is: Q99798
type: Species
name: ACO2
initial concentration: NaN

metaR r2106
reactant: MODEL1310110025#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110025#
modifier: MODEL1310110025#
reversible: true
kinetic law: MODEL1310110025#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false

metaR BACCLm
is: SBO:0000176
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 2 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
reversible: false
fast: false
modifier: MODEL1310110025#
name: biotin-[acetyl-CoA-carboxylase] ligase, mitochondrial
product: MODEL1310110025#
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.4.10
reactant: MODEL1310110025#
is described by: ECO:0000254
kinetic law: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_b5212763_5ca3_44b3_b790_5be187bdbc86
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:1337
initial concentration: NaN
constant: false
type: Species
is: P12074
name: COX6A1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110025#_d225f791_7e87_4c7f_9926_251d2a71e932
name: GLDC
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
is: P23378
is encoded by: hsa:2731
initial amount: NaN
has only substance units: false
boundary condition: true

metaR r1433
kinetic law: MODEL1310110025#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
type: Reaction
reactant: MODEL1310110025#
is: SBO:0000176
name: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9
fast: false
is described by: ECO:0000000
product: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_44300929_3596_4a9b_a724_602e669dc3c3
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110025#_75cc104e_c3c3_4bfb_a74a_5ba93acf0f09
boundary condition: true
is: SBO:0000252
name: AQP8
constant: false
is encoded by: hsa:343
type: Species
initial amount: NaN
initial concentration: NaN
is: O94778
has only substance units: false

metaR EX tcynt LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

metaR CYTK8
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110025#
name: cytidylate kinase (CMP,dATP)
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110025#
is: SBO:0000176
product: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true

metaR r0797
modifier: MODEL1310110025#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
product: MODEL1310110025#
name: glycine N-choloyltransferase EC:2.3.1.65

metaR r2094
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110025#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
type: Reaction
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110025#_9a0cc22c_9aa6_4c80_81f2_29d2b7fd8bb9
is: SBO:0000252
initial concentration: NaN
constant: false
name: SLC7A8
type: Species
initial amount: NaN
is: Q9UHI5
has only substance units: false
boundary condition: true
is encoded by: hsa:23428

http://identifiers.org/biomodels.db/MODEL1310110025#_db18749f_5a72_48c0_ba12_31c496f13e0a
boundary condition: true
constant: false
type: Species
has part: B4E3E9
has only substance units: false
is: SBO:0000297
initial concentration: NaN
name: DLD:DLST:OGDH:PDHX
initial amount: NaN
is encoded by: hsa:4967

metaM 2oxoadp m
boundary condition: false
is: CHEBI:57499
initial amount: NaN
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00225
name: 2-oxoadipate(2-)
type: Species

metaR UGT1A10r
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.4.1.17
modifier: MODEL1310110025#
fast: false
reactant: MODEL1310110025#
type: Reaction
kinetic law: MODEL1310110025#
is described by: ECO:0000134
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified

metaR CSBPASEly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
product: MODEL1310110025#
type: Reaction
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
fast: false
name: chondroitin sulfate B proteoglycan protease, lysosome (endosome)
reversible: false
is: SBO:0000176

metaR CO2ter
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110025#
type: Reaction
kinetic law: MODEL1310110025#
name: CO2 endoplasmic reticular transport via diffusion
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110025#_6b3cb434_21fe_470e_b5d9_3e82599bfc95
type: Species
is encoded by: hsa:1718
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: Q15392
boundary condition: true
initial amount: NaN
constant: false
name: DHCR24

metaM cgly c
is: HMDB00078
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
constant: false
has only substance units: false
is: CHEBI:4047
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
name: L-cysteinylglycine

metaR PIPLC
modifier: MODEL1310110025#
reversible: false
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/3.1.4.11
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (23007.1) or (113026.1) or (89869.1) or (84812.1) or (9651.1) or (5335.1) or (51196.1) or (257068.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (5330.1) or (23236.1) or (5333.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
type: Reaction
is: SBO:0000176
reactant: MODEL1310110025#
product: MODEL1310110025#
fast: false
name: phosphatidylinositol phospholipase C
is described by: ECO:0000000

metaR MELATNOX
is version of: http://identifiers.org/ec-code/1.14.13.48
type: Reaction
product: MODEL1310110025#
reversible: false
name: Melatonin:NADP oxidoreductase
reactant: MODEL1310110025#
fast: false
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.14.14.1
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (1557.1) or (1543.1) or (1545.1) or (1544.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15616152 NOTES:SAB made up name

metaR r2107
is: SBO:0000185
reversible: true
fast: false
kinetic law: MODEL1310110025#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110025#
product: MODEL1310110025#
reactant: MODEL1310110025#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction

metaM 6a2ohxnt x
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-4-2-1-3-5(8)6(9)10/h1-4,7H2,(H,9,10) EHMN_ABBREVIATION: C03239
initial amount: NaN
type: Species
name: 6-amino-2-oxohexanoic acid
is: HMDB12151
constant: false
is: SBO:0000247
is: CHEBI:17534

http://identifiers.org/biomodels.db/MODEL1310110025#_d9725eb9_2a61_4fe3_bc2a_36b4ce16e455
is: P43166
boundary condition: true
is encoded by: hsa:766
initial concentration: NaN
name: CA7
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: SBO:0000252

metaR AKR1C42
product: MODEL1310110025#
name: aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
modifier: MODEL1310110025#
is: SBO:0000176
reactant: MODEL1310110025#
reversible: false
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/1.1.1.225
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_c49f60a0_9832_4ed1_a8b9_4300307662c1
is encoded by: hsa:51604
type: Species
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
is: Q969N2
is: SBO:0000252
name: PIGT

http://identifiers.org/biomodels.db/MODEL1310110025#_9ed17def_3156_4692_bd61_d75de95a0507
initial amount: NaN
type: Species
is encoded by: hsa:1036
is: Q16878
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: CDO1

metaM 3pg m
boundary condition: false
initial amount: NaN
constant: false
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
is: SBO:0000247
is: CHEBI:58272
initial concentration: 1.0
type: Species
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
has only substance units: false
is: HMDB00807

http://identifiers.org/biomodels.db/MODEL1310110025#_d5dd5ccb_6bca_4e23_843a_ca2727bc256a
has only substance units: false
name: SLC5A7
is: Q9GZV3
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:60482

http://identifiers.org/biomodels.db/MODEL1310110025#_772b7f75_f238_4543_a09b_851e7b309f6b
is encoded by: hsa:4708
is: SBO:0000252
type: Species
constant: false
boundary condition: true
has only substance units: false
is: H7C5B8
initial amount: NaN
name: NDUFB2
initial concentration: NaN

metaM mal L m
has only substance units: false
constant: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
is: SBO:0000247
name: (S)-malate(2-)
is: CHEBI:15589
is: HMDB00156
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110025#_3b03cbfe_62b8_4e23_bcfa_00d77e13b85e
has only substance units: false
name: HIBCH
is encoded by: hsa:26275
type: Species
initial concentration: NaN
constant: false
is: Q6NVY1
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR CYTK9
product: MODEL1310110025#
modifier: MODEL1310110025#
reactant: MODEL1310110025#
name: cytidylate kinase (CMP,dCTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110025#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110025#_3b7fe412_4def_49e3_a332_7e6a82601f3d
is: SBO:0000252
type: Species
is: Q9BVG9
initial amount: NaN
is encoded by: hsa:81490
initial concentration: NaN
has only substance units: false
constant: false
name: PTDSS2
boundary condition: true

metaR r2093
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110025#
type: Reaction
product: MODEL1310110025#
reversible: true
is: SBO:0000185
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
fast: false

metaR r0796
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
modifier: MODEL1310110025#
is described by: ECO:0000000
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_9cebc62b_ee57_4ce3_b8e8_e5d942ecb61a
is encoded by: hsa:51733
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
name: UPB1
is: B3KNC1

http://identifiers.org/biomodels.db/MODEL1310110025#_32f835ec_07b1_4bb1_a7ec_f31fa4eb94a0
has only substance units: false
boundary condition: true
name: NOS3
is encoded by: hsa:4846
initial concentration: NaN
is: A0S0A7
type: Species
constant: false
initial amount: NaN
is: SBO:0000252

metaM udp c
name: UDP
is: CHEBI:58223
is: C00015
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB00295
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_6d8e7e27_287b_4171_be07_679876752a7b
has only substance units: false
is: P37837
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6888
name: TALDO1
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_41680e02_a612_42ec_b66d_c42f660f383c
name: PLCH2
is: O75038
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:9651
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_3d643629_e4d0_408d_bef3_f16ffdb64075
name: ST6GALNAC1
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:55808
constant: false
initial concentration: NaN
is: Q9NSC7

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

metaM ahcys e
notes: FORMULA: C14H20N6O5S CHARGE: 0
constant: false
type: Species
is: C00021
initial concentration: 1.0
is: HMDB00939
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:16680
initial amount: NaN
name: S-Adenosyl-L-homocysteine

http://identifiers.org/biomodels.db/MODEL1310110025#_ddafe14f_d97e_4f90_a344_3d4599d13c95
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:6648
is: P04179
name: SOD2
has only substance units: false
initial amount: NaN

metaM q10 m
constant: false
is: HMDB01072
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
is: CHEBI:46245
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
name: ubiquinone-10

metaR RE0935E
modifier: MODEL1310110025#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.1
is described by: ECO:0000000
product: MODEL1310110025#
kinetic law: MODEL1310110025#
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
reactant: MODEL1310110025#
name: RE0935
is version of: http://identifiers.org/ec-code/3.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110025#_7044e4da_7dae_40cd_9c8a_705ef17b7d00
is: Q6YFQ2
name: COX6B2
boundary condition: true
is encoded by: hsa:125965
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN

metaM T antigen g
name: T antigen (core 1)
is: SBO:0000247
notes: FORMULA: C14H24NO10X CHARGE: 0
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:22783
boundary condition: false
initial amount: NaN

metaM 4ppan c
boundary condition: false
is: HMDB01016
is: SBO:0000247
name: D-4'-Phosphopantothenate
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:10986
type: Species
is: C03492
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_154666b9_14be_46d3_b10f_cf54e01cbfa9
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: PANK1
has only substance units: false
is encoded by: hsa:53354
constant: false
initial concentration: NaN
type: Species

metaR CRNCARtp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
is: SBO:0000185
reactant: MODEL1310110025#
is described by: ECO:0000000
kinetic law: MODEL1310110025#
fast: false
name: carnitine-acetylcarnitine carrier, peroxisomal
product: MODEL1310110025#
reversible: false

metaM mal L e
boundary condition: false
initial concentration: 1.0
is: CHEBI:15589
type: Species
name: (S)-malate(2-)
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
initial amount: NaN
is: HMDB00156

metaM dgmp e
is: HMDB01044
boundary condition: false
type: Species
name: dGMP(2-)
is: SBO:0000247
is: CHEBI:57673
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362

metaR MAN6PI
reactant: MODEL1310110025#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
product: MODEL1310110025#
is described by: ECO:0000304
name: mannose-6-phosphate isomerase
fast: false
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/5.3.1.8
reversible: true
modifier: MODEL1310110025#

metaM man e
constant: false
boundary condition: false
name: D-Mannose
initial concentration: 1.0
initial amount: NaN
is: C00159
has only substance units: false
is: SBO:0000247
is: HMDB00169
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: CHEBI:16024

http://identifiers.org/biomodels.db/MODEL1310110025#_73747679_8b2b_4be1_adda_9351380ddb71
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:3948
name: LDHC
boundary condition: true
initial concentration: NaN
is: P07864
initial amount: NaN
type: Species

metaR GLUTCOADHm
is: SBO:0000176
notes: GENE_ASSOCIATION: (2639.1) or (2639.2) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 2 AUTHORS: NOTES:SAB use of FAD is not certain
reversible: false
reactant: MODEL1310110025#
is described by: ECO:0000304
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.3.99.7
type: Reaction
product: MODEL1310110025#
name: glutaryl-CoA dehydrogenase (mitochondria)
fast: false
kinetic law: MODEL1310110025#

metaR CYANt
type: Reaction
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM
fast: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110025#
reversible: true
kinetic law: MODEL1310110025#
name: Cyanide transport via diffusion (extracellular to cytosol)

metaR P45027A1m
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/1.14.13.15
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110025#
is: SBO:0000176
name: Cytochrome P450 27

metaM uri c
is: SBO:0000247
initial concentration: 1.0
is: C00299
boundary condition: false
is: CHEBI:16704
initial amount: NaN
name: Uridine
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
constant: false
type: Species
has only substance units: false
is: HMDB00296

metaR NADtx
product: MODEL1310110025#
name: transport of NAD into peroxisome
fast: false
kinetic law: MODEL1310110025#
is described by: ECO:0000134
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110025#
type: Reaction

metaR COt
kinetic law: MODEL1310110025#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110025#
fast: false
product: MODEL1310110025#
name: CO transporter via diffusion

metaM arachdcoa m
constant: false
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
is: HMDB06523
is: CHEBI:57368
boundary condition: false
name: arachidonoyl-CoA(4-)
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110025#_47856d44_0228_4f3c_b77e_9f652241d011
initial amount: NaN
name: AGPAT3
boundary condition: true
constant: false
is: Q9NRZ7
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:56894
initial concentration: NaN

metaM pro D e
boundary condition: false
constant: false
is: HMDB03411
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
is: CHEBI:16313
type: Species
name: D-proline

metaR DNDPt28m
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
name: dCDP transport via dGDP antiport
kinetic law: MODEL1310110025#
is described by: ECO:0000269
product: MODEL1310110025#
type: Reaction
modifier: MODEL1310110025#
reactant: MODEL1310110025#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110025#_8473f3a9_6d22_42a9_8f19_6e84ce2edc1e
name: RRM1
has only substance units: false
is: P23921
type: Species
is encoded by: hsa:6240
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252

metaM datp c
name: dATP
is: SBO:0000247
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: C00131
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:61404
is: HMDB01532
boundary condition: false
has only substance units: false

metaM ala L m
boundary condition: false
has only substance units: false
name: L-alanine
is: CHEBI:16977
initial amount: NaN
is: HMDB00161
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247

metaR EX man LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Mannose
type: Reaction

metaM prpp e
boundary condition: false
is: CHEBI:58017
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
is: HMDB00280
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)

metaR DESAT20 2
is described by: ECO:0000000
name: fatty acyl-CoA desaturase (n-C20:4CoA -> n-C20:5CoA)
product: MODEL1310110025#
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
fast: false
modifier: MODEL1310110025#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
reversible: false

metaM ahcys c
initial amount: NaN
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
constant: false
type: Species
is: C00021
initial concentration: 1.0
has only substance units: false
is: HMDB00939
boundary condition: false
is: SBO:0000247
name: S-Adenosyl-L-homocysteine
is: CHEBI:16680

metaR D 3AIBt
type: Reaction
fast: false
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110025#
name: D-3-amino-isobutyrate transport
is: SBO:0000185
is described by: ECO:0000000

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

metaM 34dhmald c
is: C05577
type: Species
initial amount: NaN
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
boundary condition: false
constant: false
is: SBO:0000247
name: 3,4-Dihydroxymandelaldehyde
initial concentration: 1.0
is: HMDB06242
has only substance units: false
is: http://identifiers.org/pubchem.compound/7903

metaM btn m
boundary condition: false
constant: false
name: biotinate
has only substance units: false
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
initial concentration: 1.0
is: SBO:0000247
is: HMDB00030
initial amount: NaN
is: CHEBI:57586
type: Species

metaR LEUTAm
is described by: ECO:0000269
fast: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.42
name: leucine transaminase, mitochondrial
kinetic law: MODEL1310110025#
reversible: true
product: MODEL1310110025#
reactant: MODEL1310110025#
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD

metaM pmtcrn c
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:17490
is: SBO:0000247
is: HMDB00222
name: L-palmitoylcarnitine
has only substance units: false

metaM 4mzym int1 r
initial concentration: 1.0
notes: FORMULA: C29H46O3 CHARGE: 0 INCHI: InChI=1/C29H46O3/c1-18(2)8-7-9-19(3)21-11-12-22-20-10-13-24-28(5,23(20)14-16-27(21,22)4)17-15-25(30)29(24,6)26(31)32/h8,19,21-22,24-25,30H,7,9-17H2,1-6H3,(H,31,32)/t19-,21?,22?,24?,25-,27+,28+,29-/m0/s1
name: 4-Methylzymosterol intermediate 1
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
is: HMDB06927
type: Species

metaR r2359
type: Reaction
product: MODEL1310110025#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
fast: false
kinetic law: MODEL1310110025#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110025#

metaM man c
boundary condition: false
constant: false
name: D-Mannose
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: C00159
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
type: Species
is: SBO:0000247
is: HMDB00169
is: CHEBI:16024

http://identifiers.org/biomodels.db/MODEL1310110025#_a5447631_3404_4f70_b6e8_702d0a39855b
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
name: VNN3
is encoded by: hsa:55350

http://identifiers.org/biomodels.db/MODEL1310110025#_a2991b6f_b39d_457b_a35d_cb72b218f5d1
initial amount: NaN
is encoded by: hsa:60490
boundary condition: true
is: SBO:0000252
is: Q96CD2
name: PPCDC
initial concentration: NaN
type: Species
constant: false
has only substance units: false

metaM uri e
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB00296
type: Species
is: C00299
name: Uridine
is: SBO:0000247
initial amount: NaN
is: CHEBI:16704
has only substance units: false
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299

metaM nadh r
is: HMDB01487
is: SBO:0000247
constant: false
is: CHEBI:57945
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
name: NADH(2-)
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_100b6cd1_fe66_4e22_ac8d_be9916e2c4aa
name: COX1
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is: Q7GXY8
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4512
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_4b732cf7_ba63_49f2_bc0f_eddcb1cbd846
name: BTD
has only substance units: false
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:686
is: P43251
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaM fru c
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
has only substance units: false
name: D-Fructose
is: SBO:0000247
is: CHEBI:15824
is: HMDB00660
type: Species
initial amount: NaN
boundary condition: false
is: C00095
initial concentration: 1.0

metaR r0488
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
is: SBO:0000176
fast: false
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34

http://identifiers.org/biomodels.db/MODEL1310110025#_63dd2ec5_5b41_46f8_8c02_49dc11dcc980
has only substance units: false
is encoded by: hsa:645
constant: false
boundary condition: true
initial concentration: NaN
name: BLVRB
is: P30043
is: SBO:0000252
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_84897d05_84db_43d4_843f_85e900f37adb
constant: false
has only substance units: false
is encoded by: hsa:2348
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: FOLR1

metaR DGSNt
type: Reaction
name: deoyguanosine transport via diffusion
product: MODEL1310110025#
kinetic law: MODEL1310110025#
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:

metaR r2358
reversible: true
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
fast: false
kinetic law: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110025#
product: MODEL1310110025#
is: SBO:0000185

metaM pro D c
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB03411
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
initial amount: NaN
is: CHEBI:16313
name: D-proline
type: Species

metaM cs a deg3 l
is: CHEBI:15748
initial concentration: 1.0
initial amount: NaN
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 3
has only substance units: false
is: SBO:0000247
is: HMDB00127
boundary condition: false
notes: FORMULA: C31H48NO32S2 CHARGE: -3
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_7b449529_56e3_4406_a93c_3f232a6001bd
has only substance units: false
constant: false
boundary condition: true
is: Q6GTM5
initial amount: NaN
name: SC5DL
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6309

http://identifiers.org/biomodels.db/MODEL1310110025#_d5d42f24_4831_49a1_afdb_0de63f1fe855
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:AI653169
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
name: _AI653169_1_c

http://identifiers.org/biomodels.db/MODEL1310110025#_ed7200c8_dff4_4da6_8c10_c003ac5418c7
boundary condition: true
is: SBO:0000252
is: Q6FHI7
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:762
type: Species
has only substance units: false
constant: false
name: CA4

metaR r0611
is version of: http://identifiers.org/ec-code/1.2.3.1
name: ITP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11
type: Reaction
reversible: true
product: MODEL1310110025#
fast: false
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:131802,PMID:1810251 NOTES:

metaR GLYCtm
product: MODEL1310110025#
fast: false
reactant: MODEL1310110025#
is: SBO:0000185
type: Reaction
reversible: true
is described by: ECO:0000000
name: glycerol transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
kinetic law: MODEL1310110025#

metaR r1832
is: SBO:0000185
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110025#
reversible: false
modifier: MODEL1310110025#
type: Reaction
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110025#
fast: false
is described by: ECO:0000000

metaM lnlnca l
name: alpha-linolenate
initial concentration: 1.0
is: HMDB01388
initial amount: NaN
is: CHEBI:32387
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
has only substance units: false
type: Species
constant: false
is: SBO:0000247
boundary condition: false

metaR RE2626M
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
name: RE2626
modifier: MODEL1310110025#
is: SBO:0000176
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.14.13.15
is described by: ECO:0000000
reactant: MODEL1310110025#
reversible: true
fast: false
type: Reaction

metaR EX crm hs LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acylsphingosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_2d19ad5e_feb1_4b1f_82c0_676e80a81ad7
boundary condition: true
is encoded by: hsa:92745
initial concentration: NaN
initial amount: NaN
name: SLC38A5
constant: false
type: Species
is: Q8WUX1
is: SBO:0000252
has only substance units: false

metaR AGPAT1
modifier: MODEL1310110025#
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.3.1.51
reversible: false
type: Reaction
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (10555.1) or (137964.1) or (56895.1) or (56894.2) or (56894.1) or (55326.1) or (10554.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 2.3.1.51 Confidence Level: 4 AUTHORS: NOTES:FULLR corresponds to acyl/R groups in texts. NJ
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.15
reactant: MODEL1310110025#
fast: false
name: 1-acylglycerol-3-phosphate O-acyltransferase 1
is: SBO:0000176

metaR r2357
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
fast: false
kinetic law: MODEL1310110025#
reversible: true
is described by: ECO:0000000
product: MODEL1310110025#
reactant: MODEL1310110025#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_81d1b39f_5455_4cf5_887e_949bfd0b26e9
constant: false
has only substance units: false
name: ACADL
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:33
is: P28330

http://identifiers.org/biomodels.db/MODEL1310110025#_f67fb296_160d_4297_a4ed_c9c2c6dad4d2
is: O14521
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:6392
name: SDHD

metaR THMDt4
modifier: MODEL1310110025#
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
is: SBO:0000185
fast: false
product: MODEL1310110025#
reversible: false
is described by: ECO:0000269
type: Reaction
name: thymidine transport in via sodium symport
notes: GENE_ASSOCIATION: (9154.1) or (9154.2) or (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856181 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110025#_2ce2c2a9_f441_4b49_827b_dc053bf4738e
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: O94777
name: DPM2
is encoded by: hsa:8818
initial amount: NaN
has only substance units: false
type: Species

metaR DAGK hs
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
name: Diacylglycerol phosphate kinase (homo sapiens)
reactant: MODEL1310110025#
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
is: SBO:0000176
fast: false
is described by: ECO:0000269
product: MODEL1310110025#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.107
type: Reaction

metaR r0051
modifier: MODEL1310110025#
is: SBO:0000176
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/3.1.3.5
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110025#
type: Reaction
product: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_51bbb429_f33b_4e49_91df_e1fc557559f4
is encoded by: hsa:AI024818
type: Species
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: _AI024818_1_c

http://identifiers.org/biomodels.db/MODEL1310110025#_38b222bb_7b51_40b7_886c_59bd208227c6
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
name: SLC16A3
is: O15427
has only substance units: false
is encoded by: hsa:9123
constant: false

metaR r1257
reversible: false
is described by: ECO:0000000
name: EC:6.2.1.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reactant: MODEL1310110025#
fast: false
kinetic law: MODEL1310110025#
type: Reaction
is: SBO:0000176
product: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_97b54815_e2ab_4687_a385_7d2b0679eb32
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:AL050025
constant: false
boundary condition: true
name: _AL050025_1_c
has only substance units: false
initial amount: NaN

metaR INSTt4 2
reactant: MODEL1310110025#
modifier: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD
reversible: true
product: MODEL1310110025#
is: SBO:0000185
name: inositol transport via sodium symport
fast: false
is described by: ECO:0000006
kinetic law: MODEL1310110025#

metaR EX 34dhoxpeg LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3,4-Dihydroxyphenylethyleneglycol exchange
type: Reaction

metaR DESAT20 1
name: fatty acyl-CoA desaturase (n-C20:3CoA -> n-C20:4CoA)
product: MODEL1310110025#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
modifier: MODEL1310110025#
is: SBO:0000176
reactant: MODEL1310110025#
is described by: ECO:0000000
kinetic law: MODEL1310110025#
fast: false

metaM pheacgln e
is: CHEBI:58310
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
is: SBO:0000247
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
constant: false
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB06344

http://identifiers.org/biomodels.db/MODEL1310110025#_363f168c_1109_4a05_a87a_dcfca0db62e5
is: SBO:0000252
boundary condition: true
is: P00414
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:4514
name: COX3
has only substance units: false

metaR MMCDm
notes: GENE_ASSOCIATION: (23417.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.1.1.9 Confidence Level: 1 AUTHORS: PMID:12123667,PMID:12955715 NOTES:JLR mitochondrial isoform - NCD
name: Methylmalonyl-CoA decarboxylase, mitochondrial
reactant: MODEL1310110025#
is described by: ECO:0000212
reversible: false
type: Reaction
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/4.1.1.9
kinetic law: MODEL1310110025#
product: MODEL1310110025#
is: SBO:0000176
fast: false

metaR r2356
reversible: true
is: SBO:0000185
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110025#
reactant: MODEL1310110025#
name: Organic anion transporter 5 Utilized transport

metaM fru e
boundary condition: false
initial concentration: 1.0
name: D-Fructose
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
has only substance units: false
is: CHEBI:15824
is: SBO:0000247
initial amount: NaN
is: HMDB00660
is: C00095
constant: false

metaR RE2069C
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11447235 NOTES:
product: MODEL1310110025#
kinetic law: MODEL1310110025#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: RE2069
type: Reaction
reactant: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_c476c650_7d5a_4b35_9e26_e78ac039b5ca
constant: false
is: B4DG68
initial amount: NaN
has only substance units: false
type: Species
name: NOS1
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4842

metaM fad m
is: HMDB01248
initial amount: NaN
is: CHEBI:16238
has only substance units: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
type: Species
boundary condition: false
initial concentration: 1.0
is: C00016
name: Flavin adenine dinucleotide oxidized
constant: false
is: SBO:0000247

metaR r1831
reversible: false
fast: false
modifier: MODEL1310110025#
reactant: MODEL1310110025#
name: Y+LAT2 Utilized transport
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_66fb1a11_c9dd_49b5_b858_8d07da8d54eb
is: A6NFM2
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
name: PYCR1
type: Species
is encoded by: hsa:5831

metaM nicrnt c
name: Nicotinate D-ribonucleotide
boundary condition: false
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
is: HMDB01132
type: Species
initial amount: NaN
is: CHEBI:57502
is: C01185
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110025#_1cd38d09_7901_4dae_943e_4c049f9c7aac
is encoded by: hsa:1718
constant: false
is: Q15392
type: Species
name: DHCR24
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR LEUKTRB4t
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110025#
is described by: ECO:0000000
product: MODEL1310110025#
fast: false
reactant: MODEL1310110025#
name: leukotriene B4 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true

metaM g3p c
name: Glyceraldehyde 3-phosphate
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/3930
is: C00661
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:58027
is: HMDB01112
is: SBO:0000247

metaR ILETAm
is described by: ECO:0000269
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.6.1.42
modifier: MODEL1310110025#
is: SBO:0000176
fast: false
product: MODEL1310110025#
name: isoleucine transaminase, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110025#_3ab11373_8188_46b2_bdd8_2a062957f6ab
constant: false
initial concentration: NaN
initial amount: NaN
name: DHCR24
has only substance units: false
type: Species
is encoded by: hsa:1718
boundary condition: true
is: Q15392
is: SBO:0000252

metaR HPACtr
name: hydroxyphenylacetate transport via diffusion
kinetic law: MODEL1310110025#
product: MODEL1310110025#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
reactant: MODEL1310110025#
is described by: ECO:0000000
fast: false
reversible: true

metaR FADtru
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
name: FAD transporter, endoplasmic reticulum
is described by: ECO:0000000
fast: false
product: MODEL1310110025#
is: SBO:0000185
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110025#_6be486ce_59f6_4911_a8cc_a7320790b1fc
initial amount: NaN
type: Species
initial concentration: NaN
name: STS
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:412
is: P08842
constant: false

metaR UMPK7n
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110025#
modifier: MODEL1310110025#
reversible: true
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110025#
is: SBO:0000176
type: Reaction
product: MODEL1310110025#
name: UMP kinase (dGTP),nuclear

http://identifiers.org/biomodels.db/MODEL1310110025#_d4c55b91_1247_43c4_9640_fa6c99ef215e
is encoded by: hsa:1632
initial amount: NaN
boundary condition: true
type: Species
name: ECI1
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
is: P42126

metaR r2355
fast: false
reactant: MODEL1310110025#
type: Reaction
reversible: true
product: MODEL1310110025#
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000

metaM aact c
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C3H8NO CHARGE: 1 INCHI: InChI=1S/C3H7NO/c1-3(5)2-4/h2,4H2,1H3/p+1 EHMN_ABBREVIATION: C01888
constant: false
is: CHEBI:58320
name: ammonioacetone
is: HMDB02134
type: Species
is: SBO:0000247
boundary condition: false

metaM HC02179 c
is: SBO:0000247
initial amount: NaN
constant: false
name: 20-hydroxy-arachidonate
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:34306
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748

http://identifiers.org/biomodels.db/MODEL1310110025#_b53c7906_eec1_4a59_88c9_b4f56b7bbc35
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:55902
type: Species
is: Q5QPH3
initial amount: NaN
initial concentration: NaN
constant: false
name: ACSS2

metaR r1259
reactant: MODEL1310110025#
reversible: false
fast: false
name: EC:6.2.1.3
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
kinetic law: MODEL1310110025#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110025#

metaM cs b l
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB06202
has only substance units: false
initial amount: NaN
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), free chain
constant: false

metaR PHACCOAGLNAC
type: Reaction
name: Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 2.3.1.14 Confidence Level: 2 AUTHORS: NOTES:SAB
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reactant: MODEL1310110025#
is: SBO:0000176
is described by: ECO:0000000
fast: false
reversible: false

metaR r1464
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
name: Active transport
is: SBO:0000185
reactant: MODEL1310110025#

metaR r1833
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Y+LAT2 Utilized transport
modifier: MODEL1310110025#
is: SBO:0000185
reactant: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110025#
fast: false

metaM dtmp m
name: dTMP
is: CHEBI:26999
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
type: Species
boundary condition: false
initial amount: NaN
is: HMDB01227
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
is: C00364

http://identifiers.org/biomodels.db/MODEL1310110025#_4de9c0b4_312b_446a_9079_b2a32b7a02c7
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:221
constant: false
boundary condition: true
initial amount: NaN
name: ALDH3B1
type: Species
is: P43353

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

metaM dgmp c
constant: false
is: HMDB01044
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
type: Species
is: C00362
initial amount: NaN
name: dGMP
is: CHEBI:57673
boundary condition: false

metaM HC00361 c
is: SBO:0000247
boundary condition: false
is: CHEBI:58335
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
name: sedoheptulose 1,7-bisphosphate(4-)

metaR r0339
type: Reaction
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.65
is version of: http://identifiers.org/ec-code/3.1.2.2
fast: false
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/3.1.2.22
is described by: ECO:0000000
reversible: false
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
reactant: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_98e2fe9f_98a2_4064_aba8_42bf803b6284
boundary condition: true
has part: E5KS60
has only substance units: false
type: Species
is encoded by: hsa:8803
name: SUCLG1:SUCLA2
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000297

metaR r2354
kinetic law: MODEL1310110025#
is described by: ECO:0000000
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
reactant: MODEL1310110025#
product: MODEL1310110025#

metaR EX dgsn LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyguanosine
type: Reaction

metaM CE4794 m
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,20-22,26-28,32,43-44H,4-7,10-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE4794
is: SBO:0000247
initial amount: NaN
is: CHEBI:12947
name: cis-6-dodecenoyl-CoA
constant: false

metaR LNLCt
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110025#
is described by: ECO:0000000
name: Linoleic acid (n-C18:2) transport in via diffusion
reversible: true
is: SBO:0000185

metaR r0610
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:131802,PMID:1810251,PMID:193556,PMID:2987258,PMID:6091737 NOTES:
reactant: MODEL1310110025#
fast: false
product: MODEL1310110025#
name: CTP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110025#

metaR ASPTA
is version of: http://identifiers.org/ec-code/2.6.1.1
product: MODEL1310110025#
is described by: ECO:0000269
reactant: MODEL1310110025#
type: Reaction
is: SBO:0000176
fast: false
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
name: aspartate transaminase
reversible: true
kinetic law: MODEL1310110025#

metaR P4508B11r
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.14.13.95
is: SBO:0000176
name: sterol 12-alpha-hydroxylase
notes: GENE_ASSOCIATION: (1582.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH and NADPH can both be used)
reversible: false
fast: false
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
product: MODEL1310110025#
type: Reaction
is described by: ECO:0000269

metaM hdca l
type: Species
has only substance units: false
is: CHEBI:7896
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
name: palmitate
is: HMDB00220
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249

metaM nmn c
is: SBO:0000247
is: HMDB00229
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
has only substance units: false
is: C00455
boundary condition: false
name: NMN
initial amount: NaN
is: CHEBI:14649

metaR r1575
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
product: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
kinetic law: MODEL1310110025#

metaR ESTRADIOLtr
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110025#
name: estradiol intracellular transport
kinetic law: MODEL1310110025#

metaR r1611
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110025#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110025#
product: MODEL1310110025#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR DPMVDc
reversible: false
notes: GENE_ASSOCIATION: (4597.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added t product for elemental balancing.
reactant: MODEL1310110025#
product: MODEL1310110025#
fast: false
is described by: ECO:0000134
name: diphosphomevalonate decarboxylase, cytosol
type: Reaction
modifier: MODEL1310110025#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.33
kinetic law: MODEL1310110025#

metaR r0055
is version of: http://identifiers.org/ec-code/2.4.2.7
is version of: http://identifiers.org/ec-code/2.4.2.8
product: MODEL1310110025#
kinetic law: MODEL1310110025#
name: 2-Oxopropanal:NADP+ oxidoreductase Pyruvate metabolism EC:1.2.1.49
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (353.1) or (3251.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 0 AUTHORS: PMID:20958,PMID:4383524,PMID:4391087,PMID:6014,PMID:7107625,PMID:7107626,PMID:7144586,PMID:7763257,PMID:7993370 NOTES:IT added 2 protons (are there really 2 protons produced?)
type: Reaction
fast: false
reactant: MODEL1310110025#
is: SBO:0000176
reversible: true
modifier: MODEL1310110025#

metaR r2200
modifier: MODEL1310110025#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110025#
reversible: true
fast: false
product: MODEL1310110025#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
kinetic law: MODEL1310110025#

metaR r2353
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
type: Reaction
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110025#_a79ce573_b493_4c75_a41b_2cee388ffa61
type: Species
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: PIGP
is: P57054
is encoded by: hsa:51227

metaM chol c
is: C00114
boundary condition: false
is: CHEBI:15354
initial amount: NaN
type: Species
is: SBO:0000247
name: Choline
initial concentration: 1.0
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
has only substance units: false
constant: false
is: HMDB00097

metaR THYOXt2
kinetic law: MODEL1310110025#
is: SBO:0000185
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
reactant: MODEL1310110025#
reversible: true
modifier: MODEL1310110025#
name: T4 transport via facilitated diffusion
type: Reaction
fast: false
is described by: ECO:0000269

metaR URIK1
type: Reaction
is: SBO:0000176
fast: false
modifier: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.7.1.48
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.48 Confidence Level: 4 AUTHORS: PMID:11306702,PMID:12199906,PMID:8812458 NOTES:
name: uridine kinase (ATP:Uridine)

metaM lcts e
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00220 EHMN_ABBREVIATION: C00243
initial amount: NaN
is: CHEBI:17716
is: HMDB00186
name: Lactose
has only substance units: false
is: C00243
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaR r0842
name: Postulated transport reaction
kinetic law: MODEL1310110025#
type: Reaction
reactant: MODEL1310110025#
product: MODEL1310110025#
reversible: true
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
is: SBO:0000185
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.1.72
modifier: MODEL1310110025#
fast: false

metaR r0841
is: SBO:0000185
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16756494 NOTES:
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
name: Free diffusion
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.1.1.271
reversible: true

metaM camp c
initial concentration: 1.0
notes: FORMULA: C10H11N5O6P CHARGE: -1 INCHI: InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/p-1/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00434 EHMN_ABBREVIATION: C00575
is: SBO:0000247
constant: false
type: Species
is: HMDB00058
initial amount: NaN
is: CHEBI:58165
boundary condition: false
has only substance units: false
name: 3',5'-cyclic AMP(1-)

metaR r1574
is: SBO:0000185
kinetic law: MODEL1310110025#
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110025#
product: MODEL1310110025#

metaR SUCOASm
reversible: true
fast: false
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/6.2.1.5
is version of: http://identifiers.org/ec-code/6.2.1.4
modifier: MODEL1310110025#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
name: Succinate--CoA ligase (ADP-forming)
is: SBO:0000176

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

metaM lnlnca r
constant: false
name: alpha-linolenate
type: Species
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
initial amount: NaN
initial concentration: 1.0
is: HMDB01388
is: SBO:0000247
has only substance units: false
is: CHEBI:32387
boundary condition: false

metaM eicostetcoa c
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
constant: false
type: Species
boundary condition: false
initial amount: NaN
name: eicosatetranoyl coenzyme A
is: SBO:0000247
has only substance units: false
is: C16164
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110025#_43eb6904_fab0_4b01_b858_99ba447675f0
is encoded by: hsa:55163
initial amount: NaN
name: PNPO
is: Q9NVS9
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species

metaR CITtam
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110025#
reversible: true
modifier: MODEL1310110025#
is described by: ECO:0000269
name: citrate transport, mitochondrial
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
kinetic law: MODEL1310110025#

metaR r2352
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110025#
is described by: ECO:0000000
type: Reaction
reversible: true
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
fast: false
is: SBO:0000185

metaM acmana e
is: CHEBI:17122
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
is: HMDB01129
name: N-acetyl-D-mannosamine
is: SBO:0000247
type: Species
initial amount: NaN

metaM mercplac c
notes: FORMULA: C3H5O3S CHARGE: -1 INCHI: InChI=1/C3H6O3S/c4-2(1-7)3(5)6/h2,4,7H,1H2,(H,5,6) EHMN_ABBREVIATION: C05823
is: HMDB02127
is: C05823
constant: false
initial amount: NaN
type: Species
name: 3-Mercaptolactate
is: http://identifiers.org/pubchem.compound/8118
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaR EX ncam LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinamide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_71a1ab45_b303_4a8a_a684_86c608a86468
name: PLCE1
has only substance units: false
boundary condition: true
is encoded by: hsa:51196
is: Q9P212
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_721fa000_9c3e_417b_a2a5_9aa3984935ff
is encoded by: hsa:AA526438
name: _AA526438_1_m
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110025#_69b53098_5743_4e7c_a88e_586e83231d8f
is encoded by: hsa:3033
is: Q16836
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
name: HADH
type: Species
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110025#_42605efc_bbf9_4999_9d9f_bac71a45a1aa
is: SBO:0000252
has only substance units: false
name: ATIC
constant: false
is: P31939
boundary condition: true
is encoded by: hsa:471
initial concentration: NaN
type: Species
initial amount: NaN

metaR r1612
is: SBO:0000185
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110025#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110025#
reversible: true
modifier: MODEL1310110025#
is described by: ECO:0000000

metaM dgmp m
initial amount: NaN
has only substance units: false
is: C00362
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB01044
name: dGMP
is: CHEBI:57673
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
constant: false
type: Species

metaM k c
is: CHEBI:29103
is: C00238
has only substance units: false
constant: false
is: HMDB00586
type: Species
is: SBO:0000247
initial amount: NaN
name: potassium
initial concentration: 1.0
boundary condition: false
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238

http://identifiers.org/biomodels.db/MODEL1310110025#_74d22e53_e753_493d_b73a_c7382af2fd06
is encoded by: hsa:6582
has only substance units: false
initial concentration: NaN
type: Species
name: SLC22A2
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

metaR PPAm
kinetic law: MODEL1310110025#
reversible: false
is: SBO:0000176
name: inorganic diphosphatase
fast: false
reactant: MODEL1310110025#
modifier: MODEL1310110025#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
is version of: http://identifiers.org/ec-code/3.6.1.1

metaM fad r
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:16238
is: SBO:0000247
is: HMDB01248
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
type: Species
name: Flavin adenine dinucleotide oxidized
initial amount: NaN

metaM dgdp m
is: CHEBI:58595
initial concentration: 1.0
is: HMDB00960
has only substance units: false
boundary condition: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
constant: false
name: dGDP(2-)
is: SBO:0000247
initial amount: NaN
type: Species

metaR r1573
fast: false
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110025#
product: MODEL1310110025#
kinetic law: MODEL1310110025#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR ARGLYSex
kinetic law: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (9057.1 and 6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
type: Reaction
reversible: false
modifier: MODEL1310110025#
is described by: ECO:0000269
reactant: MODEL1310110025#
fast: false
name: Arginine/Lysine exchanger (Arg in)
is: SBO:0000185

metaM 3otdcoa m
constant: false
name: 3-Oxotetradecanoyl-CoA
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:28726
boundary condition: false
has only substance units: false
is: HMDB03935
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-22,24,28-30,34,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t24-,28-,29-,30+,34-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01400 EHMN_ABBREVIATION: C05261

http://identifiers.org/biomodels.db/MODEL1310110025#_11c60954_e37a_4390_85db_42d783fa5765
name: SDHB
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: P21912
is: SBO:0000252
is encoded by: hsa:6390
boundary condition: true
constant: false
type: Species

metaR FUMSO4tm
name: Fumarate:sulfate antiport, mitochondrial
reversible: true
reactant: MODEL1310110025#
fast: false
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
type: Reaction
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is described by: ECO:0000269
is: SBO:0000185

metaM bilglcur r
is: CHEBI:57767
constant: false
has only substance units: false
name: mono(glucosyluronic acid)bilirubin(2-)
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374

metaR r0129
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.40
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
modifier: MODEL1310110025#
is: SBO:0000176
product: MODEL1310110025#
kinetic law: MODEL1310110025#
fast: false
reactant: MODEL1310110025#
type: Reaction
reversible: true

metaR r1948
product: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000000
kinetic law: MODEL1310110025#
is: SBO:0000185
reversible: false
type: Reaction
modifier: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport

metaM 3aib D m
name: D-3-Amino-isobutanoate
is: C03265
type: Species
is: SBO:0000247
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
constant: false
boundary condition: false
is: HMDB02299
initial concentration: 1.0
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_15f4af2b_44f7_4724_9e54_b470189d9078
is: SBO:0000252
is: Q11201
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:6482
name: ST3GAL1
constant: false
initial amount: NaN

metaM dgdp n
has only substance units: false
is: CHEBI:58595
constant: false
name: dGDP(2-)
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB00960
boundary condition: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361

metaR r1610
is described by: ECO:0000000
kinetic law: MODEL1310110025#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110025#
product: MODEL1310110025#
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR EX inost LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: myo-Inositol exchange
type: Reaction

metaR r0917
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110025#
is: SBO:0000185
type: Reaction
product: MODEL1310110025#
fast: false
reversible: true

metaM acmana c
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:17122
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
name: N-acetyl-D-mannosamine
constant: false
is: HMDB01129
is: SBO:0000247
type: Species
has only substance units: false

metaM dtdp m
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: C00363
is: HMDB01274
boundary condition: false
type: Species
name: dTDP
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:58369

metaM utp c
initial concentration: 1.0
type: Species
is: C00075
name: UTP
is: CHEBI:46398
boundary condition: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: HMDB00285
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_e8aa1982_2e24_45f8_bc2c_779a7bcca021
initial concentration: NaN
is: SBO:0000252
name: SGPL1
type: Species
is encoded by: hsa:8879
is: O95470
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_386cfccb_e4b7_4950_b711_516dbdbe47dd
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: O75610
is encoded by: hsa:10637
type: Species
name: LEFTY1
boundary condition: true
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_74adab65_064a_49e8_bf74_15eda5744baa
type: Species
name: ENTPD1
initial concentration: NaN
boundary condition: true
is: Q86VV3
is: SBO:0000252
constant: false
is encoded by: hsa:953
initial amount: NaN
has only substance units: false

metaM HC01602 c
constant: false
is: SBO:0000247
is: CHEBI:57454
has only substance units: false
boundary condition: false
is: C00234
name: 10-Formyltetrahydrofolate
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_408494bc_5abc_4fe0_97d7_a60a5dc78300
is: SBO:0000252
is: P35218
boundary condition: true
is encoded by: hsa:763
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
name: CA5A

http://identifiers.org/biomodels.db/MODEL1310110025#_1a88b05b_050b_4d10_b1ef_d36095e0966d
is encoded by: hsa:4524
type: Species
name: MTHFR
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
is: Q59GJ6

metaR 3MOBte
product: MODEL1310110025#
is described by: ECO:0000134
name: Transport of 3-methyl-2-oxobutanoate
reversible: true
reactant: MODEL1310110025#
fast: false
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_c9a3aeb9_b7ef_4ac4_88da_471f97cf2c44
type: Species
is: P55809
initial concentration: NaN
is encoded by: hsa:5019
is: SBO:0000252
has only substance units: false
name: OXCT1
initial amount: NaN
constant: false
boundary condition: true

metaR r1571
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110025#
reversible: true
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR GLNtm
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)
reactant: MODEL1310110025#
product: MODEL1310110025#
name: L-glutamine transport via electroneutral transporter
kinetic law: MODEL1310110025#
fast: false
is: SBO:0000185
type: Reaction

metaR EX pheacgln LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-N-Phenylacetyl-L-glutamine exchange
type: Reaction

metaR r1615
is: SBO:0000185
type: Reaction
reversible: true
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
modifier: MODEL1310110025#
is described by: ECO:0000000
product: MODEL1310110025#
reactant: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR H2Otly
name: H2O transport, lysosomal
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110025#
reversible: true
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
kinetic law: MODEL1310110025#

metaM g6p r
is: HMDB01401
is: C00092
type: Species
is: SBO:0000247
constant: false
is: CHEBI:61548
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
name: D-Glucose 6-phosphate
has only substance units: false

metaR EX 10fthf6glu LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](6) exchange
type: Reaction

metaR r0127
is described by: ECO:0000000
product: MODEL1310110025#
reversible: false
is: SBO:0000176
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
type: Reaction
fast: false
name: L-Asparagine amidohydrolase Alanine and aspartate metabolism / Cyanoamino acid metabolism / Nitrogen metabolism EC:3.5.1.1 EC:3.5.1.38
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.38 Confidence Level: 0 AUTHORS: PMID:4311065,PMID:4894450 NOTES:
is version of: http://identifiers.org/ec-code/3.5.4.16

metaM prpp c
initial amount: NaN
is: HMDB00280
is: C00119
constant: false
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: 5-Phospho-alpha-D-ribose 1-diphosphate
is: SBO:0000247
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
is: CHEBI:58017

metaR r0915
product: MODEL1310110025#
kinetic law: MODEL1310110025#
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110025#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185

metaR GLYC3PFADm
fast: false
reactant: MODEL1310110025#
reversible: false
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000176
type: Reaction
name: glycerophosphate shuttle for trasnfer of reducing equivalents
is described by: ECO:0000134
kinetic law: MODEL1310110025#

metaR r1570
reactant: MODEL1310110025#
fast: false
product: MODEL1310110025#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM nadh x
boundary condition: false
is: SBO:0000247
is: HMDB01487
is: http://identifiers.org/pubchem.compound/3306
is: C00004
type: Species
is: CHEBI:57945
name: Nicotinamide adenine dinucleotide - reduced
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_9293e9f7_f9ea_4dcd_9f4b_5898aa08f8e0
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:316
type: Species
name: AOX1
initial amount: NaN
is: Q06278

http://identifiers.org/biomodels.db/MODEL1310110025#_1ef31a7c_263a_4ba3_b1ab_adfb92a069b6
type: Species
boundary condition: true
constant: false
name: PDE3B
initial amount: NaN
is encoded by: hsa:5140
initial concentration: NaN
is: A7E2E5
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_3143078c_281f_4966_9a25_add303c7cf31
constant: false
is: SBO:0000252
boundary condition: true
name: NT5C2
is: P49902
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:22978
type: Species
has only substance units: false

metaR RE3000M
product: MODEL1310110025#
type: Reaction
reversible: true
reactant: MODEL1310110025#
name: RE3000
notes: GENE_ASSOCIATION: (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#

metaR SERGLYexR
is: SBO:0000185
reversible: true
name: L-Serine/Glycine reversible exchange
modifier: MODEL1310110025#
reactant: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
type: Reaction
kinetic law: MODEL1310110025#
fast: false

metaR XYLt
product: MODEL1310110025#
name: D-xylose reversible transport
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
is: SBO:0000185
reversible: true
modifier: MODEL1310110025#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110025#_02d83e80_25de_42a8_95a9_cc596f6ca916
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: O75610
constant: false
boundary condition: true
name: LEFTY1
type: Species
is encoded by: hsa:10637

metaR r1616
product: MODEL1310110025#
reversible: true
kinetic law: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110025#
modifier: MODEL1310110025#
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaR 5ADTSTSTERONEte
is described by: ECO:0000000
kinetic law: MODEL1310110025#
product: MODEL1310110025#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110025#
fast: false
type: Reaction
name: 5 alpha dihydrotesterone transport
reversible: true

metaR CRNrtx
is described by: ECO:0000134
product: MODEL1310110025#
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
name: reversible transport of L-Carnitine in peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: added during gap filling. NOTES:added during gap filling.
fast: false
type: Reaction
is: SBO:0000185
reversible: true

metaM dcsptn1coa x
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
initial amount: NaN
is: C16173
is: HMDB06513
boundary condition: false
type: Species
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
is: http://identifiers.org/pubchem.compound/47205483
constant: false

metaR DNDPt17m
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110025#
reversible: false
is described by: ECO:0000269
name: dUDP transport via dCDP antiport
modifier: MODEL1310110025#
product: MODEL1310110025#
is: SBO:0000185
reactant: MODEL1310110025#
type: Reaction

metaR TCHOLAte
fast: false
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is described by: ECO:0000000
reactant: MODEL1310110025#
type: Reaction
name: bile acid intracellular transport
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110025#

metaM 6dhf e
type: Species
name: hexaglutamyl folate (DHF)
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB06563
constant: false
boundary condition: false

metaM hdca r
boundary condition: false
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
initial concentration: 1.0
initial amount: NaN
is: CHEBI:7896
is: SBO:0000247
name: Hexadecanoate (n-C16:0)
constant: false
is: C00249
type: Species
is: HMDB00220
has only substance units: false

metaR r2202
is: SBO:0000185
reversible: true
type: Reaction
product: MODEL1310110025#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reactant: MODEL1310110025#
modifier: MODEL1310110025#
is described by: ECO:0000000
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false

metaR r2055
modifier: MODEL1310110025#
is described by: ECO:0000000
kinetic law: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110025#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
product: MODEL1310110025#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_dc5abade_e474_4056_a3f6_78b71691be05
name: COX6C
has only substance units: false
is encoded by: hsa:1345
type: Species
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
is: P09669

http://identifiers.org/biomodels.db/MODEL1310110025#_0fcdbac5_f466_4808_902b_d9b9fbd6dc34
name: DLD:GCSH:GLDC:AMT
is encoded by: hsa:275
is encoded by: hsa:2731
type: Species
has part: P23378
has part: P48728
has only substance units: false
constant: false
is encoded by: hsa:2653
initial concentration: NaN
boundary condition: true
is: SBO:0000297
has part: P23434
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_38d00fb0_c5c5_42a2_90d5_e912ea33ea64
name: PPCS
constant: false
type: Species
is: Q9HAB8
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:79717
boundary condition: true
has only substance units: false
initial amount: NaN

metaR CYTK12n
fast: false
kinetic law: MODEL1310110025#
type: Reaction
reactant: MODEL1310110025#
name: cytidylate kinase (dCMP,dCTP),nuclear
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110025#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110025#

metaR r1613
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
type: Reaction
modifier: MODEL1310110025#
fast: false
product: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reactant: MODEL1310110025#

metaR DM anth
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

metaM nadp c
is: SBO:0000247
is: CHEBI:58349
initial concentration: 1.0
type: Species
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: HMDB00217
name: Nicotinamide adenine dinucleotide phosphate
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
is: C00006

metaM CE0693 m
name: 3-oxolaur-6-cis-enoyl-CoA
constant: false
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB11123
is: CHEBI:28387
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
initial concentration: 1.0

metaM hLkynr c
name: 3-hydroxy-L-kynurenine
constant: false
is: HMDB11631
is: CHEBI:17380
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227

metaM chol e
type: Species
boundary condition: false
is: SBO:0000247
name: Choline
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
constant: false
initial concentration: 1.0
is: HMDB00097
has only substance units: false
is: CHEBI:15354
is: C00114
initial amount: NaN

metaR r2201
kinetic law: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110025#
fast: false
reactant: MODEL1310110025#

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

metaR r2056
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110025#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110025#
reversible: false
modifier: MODEL1310110025#
is described by: ECO:0000000
is: SBO:0000185
fast: false

metaR r0913
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reversible: true
is described by: ECO:0000000
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110025#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110025#_35c2a68b_b7d2_4b06_8218_0a319811db4a
constant: false
is: SBO:0000252
name: _AI761708_1_m
initial amount: NaN
is encoded by: hsa:AI761708
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true

metaR PAIL45P HStn
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110025#
reversible: true
reactant: MODEL1310110025#
type: Reaction

metaR 5MTHFt2le
is: SBO:0000185
name: 5-methyltetrahydrofolate transport via anion exchange
is described by: ECO:0000134
reversible: true
product: MODEL1310110025#
reactant: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110025#

metaM dhbpt c
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
is: CHEBI:20680
name: 6,7-dihydrobiopterin
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB00038
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR TYRCBOX
product: MODEL1310110025#
reactant: MODEL1310110025#
type: Reaction
fast: false
modifier: MODEL1310110025#
is: SBO:0000176
name: L-Tyrosine carboxy-lyase
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
is described by: ECO:0000134
reversible: false
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/4.1.1.28

metaR RE2799C
name: RE2799
product: MODEL1310110025#
is described by: ECO:0000000
kinetic law: MODEL1310110025#
fast: false
is: SBO:0000176
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
reactant: MODEL1310110025#

metaR r1614
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
product: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110025#
reversible: true
modifier: MODEL1310110025#
is described by: ECO:0000000
is: SBO:0000185

metaR CREATt4 2 r
type: Reaction
modifier: MODEL1310110025#
reversible: true
kinetic law: MODEL1310110025#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is described by: ECO:0000269
reactant: MODEL1310110025#
product: MODEL1310110025#
name: Creatine transport (sodium symport) (2:1)

metaM dtmp e
initial concentration: 1.0
has only substance units: false
name: dTMP(2-)
boundary condition: false
is: HMDB01227
type: Species
is: SBO:0000247
is: CHEBI:26999
initial amount: NaN
constant: false
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364

metaM mal L c
type: Species
constant: false
boundary condition: false
is: CHEBI:15589
is: HMDB00156
initial amount: NaN
has only substance units: false
name: (S)-malate(2-)
is: SBO:0000247
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
initial concentration: 1.0

metaM q10h2 m
type: Species
is: HMDB13111
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
has only substance units: false
is: http://identifiers.org/pubchem.compound/6504740
boundary condition: false
name: Ubiquinol-10
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110025#_56cb9d95_1a98_41c6_a822_4e3b953dfe1e
is: SBO:0000297
initial amount: NaN
has part: Q96I99
type: Species
has part: P53597
name: SUCLG2:SUCLG1
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:8802
is encoded by: hsa:8801

http://identifiers.org/biomodels.db/MODEL1310110025#_ebce50fe_a784_4a12_80f7_f2f1ea68a8d6
is: Q96Q11
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:51095
initial amount: NaN
type: Species
constant: false
has only substance units: false
name: TRNT1

metaR r1955
reversible: false
fast: false
is described by: ECO:0000000
product: MODEL1310110025#
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
type: Reaction
reactant: MODEL1310110025#
modifier: MODEL1310110025#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110025#_ad3084a7_ebb7_41ba_9df9_7075dcd545ed
is: B4DG68
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
name: NOS1
constant: false
is encoded by: hsa:4842

metaR r1608
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_1e9394bb_b3be_4274_8d66_aaf9576832dd
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:AI222095
boundary condition: true
name: _AI222095_1_m
is: SBO:0000252

metaM ivcoa m
initial concentration: 1.0
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB01113
name: Isovaleryl-CoA
is: CHEBI:57345
initial amount: NaN
type: Species

metaM oxa c
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:30623
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
constant: false
name: oxalate(2-)
is: HMDB02329
type: Species
boundary condition: false

metaM anth e
is: HMDB01123
initial amount: NaN
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
type: Species
name: anthranilate
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:16567
initial concentration: 1.0
has only substance units: false

metaR RE0577C
fast: false
kinetic law: MODEL1310110025#
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.3.1.65
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
reactant: MODEL1310110025#
name: RE0577
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.2.2
modifier: MODEL1310110025#
reversible: true

metaR CLHCO3tex2
modifier: MODEL1310110025#
reversible: false
reactant: MODEL1310110025#
product: MODEL1310110025#
fast: false
name: chloride transport via bicarbonate countertransport (2:1)
is: SBO:0000185
is described by: ECO:0000304
type: Reaction
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
kinetic law: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_545c1afe_e76f_484d_9d24_fe81bfa173b6
has only substance units: false
name: NT5C1B
is encoded by: hsa:93034
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is: Q96P26

metaR GGH 10FTHF7GLUe
type: Reaction
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
product: MODEL1310110025#
is: SBO:0000176
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
name: Gamma-glutamyl hydrolase (10FTHF7GLU), extracellular
is version of: http://identifiers.org/ec-code/3.4.19.9
fast: false
modifier: MODEL1310110025#

metaR HACD9m
kinetic law: MODEL1310110025#
type: Reaction
reactant: MODEL1310110025#
modifier: MODEL1310110025#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110025#
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
is described by: ECO:0000134
fast: false

http://identifiers.org/biomodels.db/MODEL1310110025#_25c6c4f6_ee36_456e_94e8_2d5eba20f7f3
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
constant: false
is: P35475
is encoded by: hsa:3425
boundary condition: true
initial concentration: NaN
name: IDUA

http://identifiers.org/biomodels.db/MODEL1310110025#_a573dce0_a3c1_476c_b3ea_6ffe1b382974
name: _R14373_1_x
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:R14373
boundary condition: true
constant: false
initial concentration: NaN

metaR PHCDm
type: Reaction
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464,PMID:500817 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.5.1.12
fast: false
kinetic law: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000304
name: L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase
modifier: MODEL1310110025#
reactant: MODEL1310110025#
reversible: false
is: SBO:0000176

metaM malthp e
has only substance units: false
constant: false
is: SBO:0000247
name: maltoheptaose
is: C01936
initial amount: NaN
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/5041
initial concentration: 1.0
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837

metaR r1607
product: MODEL1310110025#
kinetic law: MODEL1310110025#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110025#
fast: false
reversible: true

metaR r0838
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
product: MODEL1310110025#
fast: false
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.2.4
reactant: MODEL1310110025#
name: Free diffusion

metaR r0541
fast: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
product: MODEL1310110025#
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/3.6.1.5
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
modifier: MODEL1310110025#
reactant: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_3def60e7_2119_41ae_9946_15125a6f8f09
boundary condition: true
constant: false
is: A6NN98
initial concentration: NaN
is: SBO:0000252
name: MTMR2
type: Species
has only substance units: false
is encoded by: hsa:8898
initial amount: NaN

metaM grdp x
notes: FORMULA: C10H17O7P2 CHARGE: -3 INCHI: InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/p-3/b10-7+ HEPATONET_1.0_ABBREVIATION: HC00288 EHMN_ABBREVIATION: C00341
is: SBO:0000247
constant: false
is: CHEBI:58057
is: HMDB01285
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
name: geranyl diphosphate(3-)
initial amount: NaN

metaM acmanap c
name: N-acetyl-D-mannosamine 6-phosphate(2-)
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:58557
has only substance units: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-4(11)9-5(2-10)7(13)8(14)6(12)3-18-19(15,16)17/h2,5-8,12-14H,3H2,1H3,(H,9,11)(H2,15,16,17)/p-2 HEPATONET_1.0_ABBREVIATION: HC01257 EHMN_ABBREVIATION: C04257
boundary condition: false
type: Species
is: HMDB01121
initial amount: NaN

metaM mescoa m
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
initial amount: NaN
has only substance units: false
is: C06028
constant: false
name: Mesaconyl-CoA
is: CHEBI:27969
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247

metaM glyc R c
has only substance units: false
is: CHEBI:16659
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
type: Species
is: HMDB00139
boundary condition: false
initial amount: NaN
name: D-glycerate

metaR RAI1
reactant: MODEL1310110025#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110025#
name: retinal isomerase (11-cis)
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110025#_aaa7c6d1_19db_46e4_b123_0fd5d0e0bf12
name: MTR
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:4548
is: Q99707
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110025#_bce6635e_6a89_4226_8c96_55b6c5f43d1a
is encoded by: hsa:9057
is: SBO:0000297
name: SLC3A2:SLC7A6
initial concentration: NaN
has part: Q92536
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_25969ccc_9387_410d_b878_3d1dfd8a4e4c
is: P16260
is: SBO:0000252
name: SLC25A16
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:8034
initial amount: NaN
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_b89647f7_8bf0_4b81_a1a6_4a7fd25481f7
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:1738
initial concentration: NaN
is: P09622
boundary condition: true
name: DLD
has only substance units: false
initial amount: NaN

metaM nadh c
is: CHEBI:57945
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/3306
has only substance units: false
constant: false
name: Nicotinamide adenine dinucleotide - reduced
is: C00004
is: HMDB01487
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR r0835
is: SBO:0000185
type: Reaction
product: MODEL1310110025#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
fast: false
modifier: MODEL1310110025#
is described by: ECO:0000000
reactant: MODEL1310110025#
reversible: true
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is version of: http://identifiers.org/ec-code/3.5.4.16
kinetic law: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_3f0251eb_4662_46e9_b433_20b7e328f6fa
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
name: SLC4A3
has only substance units: false
is encoded by: hsa:6508
boundary condition: true
is: P48751

metaR r2419
fast: false
product: MODEL1310110025#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:

metaR FALDH
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
fast: false
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
product: MODEL1310110025#
type: Reaction
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110025#
is: SBO:0000176
name: formaldehyde dehydrogenase
is version of: http://identifiers.org/ec-code/1.1.1.1

metaR r1606
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110025#
fast: false
reactant: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

metaR DTTPtn
reversible: true
is described by: ECO:0000000
product: MODEL1310110025#
is: SBO:0000185
name: dTTP diffusion in nucleus
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
fast: false

metaR EX tre LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Trehalose exchange
type: Reaction

metaR GGH 6DHFe
type: Reaction
reversible: false
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/3.4.19.9
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
name: Gamma-glutamyl hydrolase (6DHF), extracellular
is described by: ECO:0000000
product: MODEL1310110025#

metaR HOXG
name: Heme oxygenase 1
reactant: MODEL1310110025#
is: SBO:0000176
reversible: false
is described by: ECO:0000134
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.14.99.3
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (3162.1) or (3163.1) SUBSYSTEM: Heme degradation EC Number: 1.14.99.3 Confidence Level: 0 AUTHORS: PMID:16356137 NOTES:TDV (4/28/2004) There are conflicting data on how many moles of NADPH consumed per mole of Biliverdine (Tenhunen 1969, Ryter, 2000). Heme oxygenase is a well known enzyme
fast: false
type: Reaction
product: MODEL1310110025#

metaM anth c
type: Species
is: HMDB01123
initial amount: NaN
name: anthranilate
boundary condition: false
constant: false
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
has only substance units: false
is: CHEBI:16567
is: SBO:0000247
initial concentration: 1.0

metaM c226crn c
has only substance units: false
type: Species
is: http://identifiers.org/pubchem.compound/127055
boundary condition: false
is: SBO:0000247
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
initial concentration: 1.0
constant: false
is: HMDB06510
name: cervonyl carnitine
initial amount: NaN

metaM mev R c
is: HMDB00227
type: Species
is: SBO:0000247
constant: false
is: CHEBI:36464
initial amount: NaN
name: (R)-mevalonate
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaR r2132
is described by: ECO:0000000
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
type: Reaction
reversible: true
fast: false
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110025#

metaM 3oddcoa m
type: Species
is: HMDB03937
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:27868
name: 3-Oxododecanoyl-CoA
is: SBO:0000247
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
boundary condition: false

metaM 3aib D e
type: Species
initial concentration: 1.0
constant: false
is: C03265
boundary condition: false
has only substance units: false
is: HMDB02299
is: SBO:0000247
initial amount: NaN
name: D-3-Amino-isobutanoate
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715

metaM dtdp e
constant: false
is: HMDB01274
boundary condition: false
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
type: Species
initial concentration: 1.0
is: CHEBI:58369
is: SBO:0000247
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
initial amount: NaN
has only substance units: false

metaR CYSGLTH
kinetic law: MODEL1310110025#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
is described by: ECO:0000000
reactant: MODEL1310110025#
product: MODEL1310110025#
reversible: true
is: SBO:0000176
name: Glutathione:cystine oxidoreductase

http://identifiers.org/biomodels.db/MODEL1310110025#_b636d20a_fb03_44a9_81b2_4b3b36760f6e
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AA081045
constant: false
name: _AA081045_1_m

metaR HISD
product: MODEL1310110025#
modifier: MODEL1310110025#
name: histidase
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110025#
fast: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.3.1.3
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (3034.1) SUBSYSTEM: Histidine metabolism EC Number: 4.3.1.3 Confidence Level: 4 AUTHORS: PMID:8530107 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110025#_a9540b1b_bc7c_4b84_9d1a_56c1d0d53c2d
constant: false
name: _AI915649_1_c
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:AI915649
is: SBO:0000252
boundary condition: true

metaR PMTCOAtx
reactant: MODEL1310110025#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110025#
product: MODEL1310110025#
type: Reaction
name: fatty acid intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110025#_ddd7b043_e034_4ef4_897f_600005c276e4
name: NDUFA4L2
is encoded by: hsa:56901
is: SBO:0000252
is: Q9NRX3
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN

metaR HEX7
type: Reaction
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.2
notes: GENE_ASSOCIATION: (2645.2) or (2645.3) or (3098.3) or (3098.1) or (3101.1) or (3098.2) or (3099.1) or (2645.1) or (3098.4) or (80201.1) or (3098.5) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. Same as 2.7.1.4
is described by: ECO:0000304
name: hexokinase (D-fructose:ATP)
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
product: MODEL1310110025#
reversible: false
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.7.1.1

http://identifiers.org/biomodels.db/MODEL1310110025#_6980db5a_c855_4b01_bd7f_d0c2c8199eeb
type: Species
boundary condition: true
constant: false
initial amount: NaN
is: Q6ZWP6
has only substance units: false
is encoded by: hsa:27034
name: ACAD8
initial concentration: NaN
is: SBO:0000252

metaM CE2431 m
is: http://identifiers.org/pubchem.compound/5041
has only substance units: false
constant: false
name: cis-deca-4-enoyl-CoA
is: SBO:0000247
is: C01936
type: Species
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaR EX 7dhf LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (DHF) exchange
type: Reaction

metaM 4abutn m
initial concentration: 1.0
is: HMDB01080
boundary condition: false
name: 4-ammoniobutanal
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
initial amount: NaN
is: CHEBI:58264
has only substance units: false

metaR DTTPtm
reversible: false
reactant: MODEL1310110025#
name: transport of dTTP into mitochondria
type: Reaction
is: SBO:0000185
product: MODEL1310110025#
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID: 16816105, PMID: 17403938. NOTES:

metaR r0836
is version of: http://identifiers.org/ec-code/3.5.4.16
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110025#
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
fast: false
type: Reaction
reactant: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_d7623e98_b49e_4481_a2c4_f617fa1584d0
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
name: GPX3
boundary condition: true
is encoded by: hsa:2878
constant: false
is: P22352
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_8cadba91_28c9_4f76_895b_ffea7631af3f
is: Q9HBH5
type: Species
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:57665
name: RDH14
initial amount: NaN
initial concentration: NaN

metaR r1605
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110025#
reversible: true
fast: false
reactant: MODEL1310110025#
product: MODEL1310110025#

metaR HISCAT1
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

metaM HC01415 m
constant: false
name: (2E)-Octenoyl-CoA
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:27537
boundary condition: false
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276
is: SBO:0000247

metaR r2133
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
modifier: MODEL1310110025#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110025#

metaR ABUTD
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.3
name: Aminobutyraldehyde dehydrogenase
product: MODEL1310110025#
type: Reaction
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
is: SBO:0000176
notes: GENE_ASSOCIATION: (223.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.19 Confidence Level: 4 AUTHORS: PMID:8786138 NOTES:JLR
reactant: MODEL1310110025#
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110025#_953f24e9_3848_45b1_b412_fbcd6150bb18
name: SLC12A6
has only substance units: false
type: Species
initial amount: NaN
constant: false
boundary condition: true
is: Q9UHW9
is encoded by: hsa:9990
initial concentration: NaN
is: SBO:0000252

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

metaR NH4t3r
modifier: MODEL1310110025#
product: MODEL1310110025#
is: SBO:0000185
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
reversible: true
type: Reaction
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
name: ammonia transport via proton antiport

metaR DHCRD1
is described by: ECO:0000269
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
product: MODEL1310110025#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
modifier: MODEL1310110025#
reversible: false
type: Reaction
name: dihydroceramide desaturase
fast: false

http://identifiers.org/biomodels.db/MODEL1310110025#_044a7f87_0792_4f95_a996_1f0056a79794
is: P23786
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: CPT2
type: Species
is encoded by: hsa:1376
has only substance units: false
constant: false

metaR EX 4nph LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenol exchange
type: Reaction

metaR 5MTAte
fast: false
reactant: MODEL1310110025#
name: Transport of 5-S-methyl-5-thioadenosine
kinetic law: MODEL1310110025#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
type: Reaction
product: MODEL1310110025#
is: SBO:0000185

metaM leuktrC4 c
is: HMDB01198
type: Species
boundary condition: false
is: CHEBI:57973
initial amount: NaN
constant: false
name: leukotriene C4(2-)
is: SBO:0000247
has only substance units: false
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
initial concentration: 1.0

metaR UMPK6
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110025#
is: SBO:0000176
reversible: true
name: UMP kinase (dCTP)
fast: false
is described by: ECO:0000269
type: Reaction
product: MODEL1310110025#
modifier: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_87574541_02c3_496b_944d_8e069023ceec
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:4709
initial concentration: NaN
is: Q6IB80
name: NDUFB3
is: SBO:0000252
constant: false
initial amount: NaN

metaR FORtr
is: SBO:0000185
name: FOR transporter, endoplasmic reticulum
kinetic law: MODEL1310110025#
type: Reaction
product: MODEL1310110025#
reversible: true
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
fast: false
is described by: ECO:0000000

metaR PROt4 2 r
name: Proline transport (sodium symport) (2:1)
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000006
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
type: Reaction
reactant: MODEL1310110025#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110025#_f19b9d75_abbe_49ef_87b5_062ebc4b3ae1
is: Q9Y5P6
is: SBO:0000252
has only substance units: false
is encoded by: hsa:29925
constant: false
type: Species
name: GMPPB
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaR VALTAm
modifier: MODEL1310110025#
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.42
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
kinetic law: MODEL1310110025#
is described by: ECO:0000269
product: MODEL1310110025#
name: valine transaminase, mitochondiral
is: SBO:0000176
reversible: true
fast: false

metaR r1578
fast: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110025#
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaR r2130
kinetic law: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110025#
type: Reaction
modifier: MODEL1310110025#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reversible: true
product: MODEL1310110025#

metaR r0834
is version of: http://identifiers.org/ec-code/3.5.4.16
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110025#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is: SBO:0000185
product: MODEL1310110025#
modifier: MODEL1310110025#
type: Reaction
reversible: true
reactant: MODEL1310110025#

metaR r1579
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
reversible: true
is: SBO:0000185
product: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

metaR UMPK7
product: MODEL1310110025#
reversible: true
is: SBO:0000176
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
modifier: MODEL1310110025#
name: UMP kinase (dGTP)
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110025#_792daf79_3fef_4a23_ae7e_6ec824776bd8
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:7296
name: TXNRD1
has only substance units: false
type: Species
initial concentration: NaN

metaR EX biocyt LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biocytin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_b252ea0d_2094_4c5e_8444_469abf0a41cf
type: Species
constant: false
initial amount: NaN
is: P11310
is encoded by: hsa:34
name: ACADM
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR r2131
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
product: MODEL1310110025#
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110025#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110025#_eeb26e27_be04_4b46_a2c2_496e14e05e1a
type: Species
boundary condition: true
name: IDI2
has only substance units: false
is encoded by: hsa:91734
is: SBO:0000252
constant: false
is: Q9BXS1
initial amount: NaN
initial concentration: NaN

metaR CYTK4n
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110025#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110025#
name: cytidylate kinase (dCMP,GTP),nuclear
is described by: ECO:0000269
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
reversible: true

metaR EX q10 LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinone
type: Reaction

metaM nadp m
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: C00006
initial concentration: 1.0
is: HMDB00217
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
name: Nicotinamide adenine dinucleotide phosphate
is: CHEBI:58349

metaR r2061
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: false
fast: false
type: Reaction

metaM k e
name: potassium
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:29103
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
is: HMDB00586
is: C00238

metaM glyald c
type: Species
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
is: SBO:0000247
is: CHEBI:17378
has only substance units: false
is: HMDB01051
name: D-Glyceraldehyde
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
is: C00577

metaR PGLer
modifier: MODEL1310110025#
name: 6-phosphogluconolactonase, endoplasmic reticulum
kinetic law: MODEL1310110025#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110025#
reactant: MODEL1310110025#
is: SBO:0000176
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 3.1.1.31 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:SMP Net reaction same as described in Lehringer 334 NCD
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.47
reversible: false

metaR UMPK4
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
fast: false
is: SBO:0000176
reactant: MODEL1310110025#
is described by: ECO:0000269
modifier: MODEL1310110025#
type: Reaction
product: MODEL1310110025#
name: UMP kinase (GTP)
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM leuktrC4 e
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
type: Species
is: CHEBI:57973
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
name: leukotriene C4(2-)
is: HMDB01198
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_b45c65fb_18b4_4db5_ae6c_fafb8bb8ce9b
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4129
initial concentration: NaN
name: MAOB
type: Species
is: P27338
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110025#_22f68326_4c13_4474_bef8_6ffc2b11810a
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
name: CHKA
is encoded by: hsa:1119
constant: false
initial amount: NaN

metaR RE1527M
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
kinetic law: MODEL1310110025#
reversible: true
name: RE1527
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
reactant: MODEL1310110025#
type: Reaction
modifier: MODEL1310110025#
fast: false

metaR PEAMNO
product: MODEL1310110025#
name: Phenethylamine oxidase
is version of: http://identifiers.org/ec-code/1.4.3.4
type: Reaction
notes: GENE_ASSOCIATION: (314.1) or (4128.1) or (26.1) or (4129.1) or (314.2) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:10389141,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:JLR- Kegg reaction R02613
kinetic law: MODEL1310110025#
is described by: ECO:0000304
reactant: MODEL1310110025#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.4.3.21
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.4.3.22
fast: false

metaR SMPD4
fast: false
reactant: MODEL1310110025#
name: sphingomyelinase
is: SBO:0000176
kinetic law: MODEL1310110025#
type: Reaction
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ
product: MODEL1310110025#

metaR r1576
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110025#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110025#
reversible: true

metaM gdp n
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
constant: false
is: HMDB01201
is: SBO:0000247
initial concentration: 1.0
type: Species
name: GDP(3-)
is: CHEBI:58189
boundary condition: false

metaR GGH 6THFe
product: MODEL1310110025#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.19.9
name: Gamma-glutamyl hydrolase (6THF), extracellular
type: Reaction
kinetic law: MODEL1310110025#
reversible: false
modifier: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is described by: ECO:0000000
fast: false

metaM hco3 m
name: Bicarbonate
is: CHEBI:17544
has only substance units: false
type: Species
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB00595
initial amount: NaN
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
initial concentration: 1.0
is: C00288

metaR HXPRT
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.4.2.8
reversible: false
fast: false
modifier: MODEL1310110025#
is described by: ECO:0000269
product: MODEL1310110025#
name: hypoxanthine phosphoribosyltransferase (Hypoxanthine)
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine (see GUAPRT) and 6-mercaptopurine can replace hypoxanthine
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110025#

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

metaR UMPK5
reactant: MODEL1310110025#
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110025#
reversible: true
type: Reaction
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110025#
name: UMP kinase (dATP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false

metaR r1609
is: SBO:0000185
kinetic law: MODEL1310110025#
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM pmtcrn x
constant: false
type: Species
name: L-palmitoylcarnitine
boundary condition: false
is: CHEBI:17490
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: HMDB00222
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR NDPK6m
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
type: Reaction
kinetic law: MODEL1310110025#
fast: false
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
reactant: MODEL1310110025#
modifier: MODEL1310110025#
product: MODEL1310110025#
is: SBO:0000176
reversible: true
is described by: ECO:0000254

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_6317cb92_df65_43a3_8966_4033d2bc6d6e
constant: false
is: SBO:0000252
type: Species
is: P50135
initial amount: NaN
name: HNMT
is encoded by: hsa:3176
initial concentration: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110025#_cea50485_dede_473b_b079_86c1b8329f57
has only substance units: false
boundary condition: true
is encoded by: hsa:NM 001929
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
name: _NM_001929_1_c

metaM pac c
is: HMDB00209
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
name: phenylacetate
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
boundary condition: false
has only substance units: false
is: CHEBI:18401
initial amount: NaN

metaM pchol hs m
type: Species
boundary condition: false
is: CHEBI:16110
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: Phosphatidylcholine
has only substance units: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157

metaR 4MOPt2im
reversible: false
type: Reaction
name: 4-methyl-2-oxopentanoate mitochondrial transport via proton symport
fast: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110025#
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM

metaM gdp m
initial concentration: 1.0
name: GDP
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:58189
is: C00035
boundary condition: false
type: Species
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: HMDB01201

metaR EX cyan LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen cyanide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_f2531cf1_8610_4453_96f4_5d7cae82fd7e
initial concentration: NaN
name: PANK1
is: Q8TE04
constant: false
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:53354

metaM dhlpro m
is: SBO:0000247
notes: FORMULA: H2S2X CHARGE: 0 EHMN_ABBREVIATION: C02972
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:16194
name: Dihydrolipolprotein
constant: false
initial concentration: 1.0
type: Species

metaM xyl D e
type: Species
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15936
has only substance units: false
constant: false
name: aldehydo-D-xylose

metaM nadh m
is: C00004
is: HMDB01487
constant: false
is: SBO:0000247
name: Nicotinamide adenine dinucleotide - reduced
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57945
boundary condition: false
is: http://identifiers.org/pubchem.compound/3306
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_a0df473b_99f6_4282_ab76_d98520782b80
type: Species
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AI656480
name: _AI656480_1_m
initial concentration: NaN

metaR EX dhf LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 7,8-Dihydrofolate exchange
type: Reaction

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_ea4327a6_bfc0_43a2_b3f8_c4f6f8ab7d06
initial amount: NaN
name: DGKD
is: SBO:0000252
constant: false
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8527
is: Q16760

http://identifiers.org/biomodels.db/MODEL1310110025#_347522da_cf8d_4ac5_a354_21f33fdfee1b
is encoded by: hsa:1119
boundary condition: true
type: Species
constant: false
is: P35790
name: CHKA
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110025#_bb872721_14c5_4342_9d5b_b0f971aa5b4b
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
is: Q6LEN5
is encoded by: hsa:1103
name: CHAT

metaR HEX1
product: MODEL1310110025#
kinetic law: MODEL1310110025#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.2
fast: false
reactant: MODEL1310110025#
modifier: MODEL1310110025#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.1
name: hexokinase (D-glucose:ATP)
type: Reaction
reversible: false

metaM 34dhoxpeg c
name: 3,4-Dihydroxyphenylethyleneglycol
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C8H10O4 CHARGE: 0 INCHI: InChI=1/C8H10O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8-12H,4H2 EHMN_ABBREVIATION: C05576
is: HMDB00318
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: C05576
is: http://identifiers.org/pubchem.compound/7902

metaR C4STMO2r
notes: GENE_ASSOCIATION: (6307.1) or (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.1.1.170
reversible: false
reactant: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000000
fast: false
name: C-4 methyl sterol oxidase
is version of: http://identifiers.org/ec-code/1.14.13.72
modifier: MODEL1310110025#
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110025#_4a323585_5237_450d_ae80_4d047d8528f1
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:114
boundary condition: true
type: Species
constant: false
name: ADCY8
is: Q4F7X0

metaR UMPK2
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110025#
type: Reaction
reversible: true
name: UMP kinase (CTP)
modifier: MODEL1310110025#
fast: false

metaR r0604
reactant: MODEL1310110025#
fast: false
product: MODEL1310110025#
is: SBO:0000176
name: (S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
type: Reaction

metaM nh4 e
name: ammonium
is: HMDB00051
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:28938
has only substance units: false
initial amount: NaN
type: Species

metaR SERGLNexR
product: MODEL1310110025#
fast: false
reversible: true
name: L-Serine/Glutamine reversible exchange
is: SBO:0000185
is described by: ECO:0000304
type: Reaction
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110025#

metaM dhcholestanate c
has only substance units: false
type: Species
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
initial concentration: 1.0
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:16577
is: HMDB00359
initial amount: NaN

metaR PRO Dtde
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
reactant: MODEL1310110025#
reversible: true
product: MODEL1310110025#
type: Reaction
is described by: ECO:0000134
is: SBO:0000185
kinetic law: MODEL1310110025#
fast: false
name: D-proline transport, extracellular

metaM 4abutn c
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C4H10NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
constant: false
boundary condition: false
name: 4-Aminobutanal
is: CHEBI:58264
is: SBO:0000247
is: C00555
is: HMDB01080

metaM CE5120 m
boundary condition: false
initial amount: NaN
has only substance units: false
name: trans-2-cis-8-tetradecadienoyl-CoA
constant: false
initial concentration: 1.0
is: CHEBI:12947
type: Species
is: SBO:0000247
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,14-15,22-24,28-30,34,45-46H,4-7,10-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5120

metaM datp m
type: Species
is: SBO:0000247
initial amount: NaN
name: dATP
is: C00131
is: HMDB01532
initial concentration: 1.0
is: CHEBI:61404
constant: false
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
has only substance units: false
boundary condition: false

metaM aact m
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C3H8NO CHARGE: 1 INCHI: InChI=1S/C3H7NO/c1-3(5)2-4/h2,4H2,1H3/p+1 EHMN_ABBREVIATION: C01888
is: HMDB02134
is: CHEBI:58320
name: ammonioacetone

metaR r0400
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.4.4
modifier: MODEL1310110025#
is: SBO:0000176
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
product: MODEL1310110025#
reversible: true
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
fast: false
is described by: ECO:0000000

metaR CO2tm
reactant: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
is: SBO:0000185
reversible: true
is described by: ECO:0000000
product: MODEL1310110025#
fast: false
kinetic law: MODEL1310110025#
name: CO2 transport (diffusion), mitochondrial

metaR GGH 7DHFe
fast: false
type: Reaction
reversible: false
modifier: MODEL1310110025#
is described by: ECO:0000000
product: MODEL1310110025#
kinetic law: MODEL1310110025#
name: Gamma-glutamyl hydrolase (7DHF), extracellular
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/3.4.19.9
is: SBO:0000176
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT

http://identifiers.org/biomodels.db/MODEL1310110025#_60e29823_9e84_459b_8765_888531915d61
has only substance units: false
is: B7Z792
initial amount: NaN
name: NDUFS2
type: Species
is encoded by: hsa:4720
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110025#_51f20578_af9d_45c8_bef7_27fcd4437566
name: _AI935189_1_m
has only substance units: false
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AI935189

http://identifiers.org/biomodels.db/MODEL1310110025#_2a109213_c6cb_41eb_a881_742c86303aef
has part: Q8TEQ8
name: PIGF:PIGO
initial concentration: NaN
has part: Q07326
is encoded by: hsa:84720
has only substance units: false
type: Species
is encoded by: hsa:5281
boundary condition: true
constant: false
is: SBO:0000297
initial amount: NaN

metaM glutcoa m
type: Species
is: HMDB01339
has only substance units: false
name: glutaryl-CoA(5-)
boundary condition: false
is: SBO:0000247
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
constant: false
initial amount: NaN
is: CHEBI:57378
initial concentration: 1.0

metaR BTNPL
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/6.3.4.10
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
product: MODEL1310110025#
name: holocarboxylase synthestase (biotin protein ligase)
fast: false
type: Reaction
kinetic law: MODEL1310110025#
is described by: ECO:0000000
reactant: MODEL1310110025#
modifier: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_c646a3bb_b53f_4db4_aa63_9b2c8ec86ee4
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:26503
initial amount: NaN
type: Species
name: SLC17A5
is: Q9NRA2
boundary condition: true

metaR UMPK3
name: UMP kinase (UTP)
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
modifier: MODEL1310110025#
type: Reaction
product: MODEL1310110025#
reactant: MODEL1310110025#

metaM 34dhmald m
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
name: 3,4-Dihydroxymandelaldehyde
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
is: C05577
type: Species
is: HMDB06242
is: http://identifiers.org/pubchem.compound/7903

http://identifiers.org/biomodels.db/MODEL1310110025#_40d19d32_b257_4eaf_b56c_c5b0103f4bd0
is encoded by: hsa:1738
is encoded by: hsa:1743
name: DLD:DLST:OGDH:PDHX
has part: Q02218
has part: P09622
initial amount: NaN
is encoded by: hsa:8050
type: Species
is encoded by: hsa:4967
has only substance units: false
initial concentration: NaN
has part: O00330
has part: P36957
constant: false
is: SBO:0000297
boundary condition: true

metaR r0549
is described by: ECO:0000000
is: SBO:0000176
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/6.1.1.17
is version of: http://identifiers.org/ec-code/1.6.5.3
product: MODEL1310110025#
modifier: MODEL1310110025#
type: Reaction
reactant: MODEL1310110025#
fast: false
is version of: http://identifiers.org/ec-code/1.6.99.3
kinetic law: MODEL1310110025#

metaM urate e
is: CHEBI:17775
is: HMDB00289
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
is: C00366
name: Urate
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false

metaR RE3626M
reactant: MODEL1310110025#
reversible: false
name: RE3626
modifier: MODEL1310110025#
is: SBO:0000176
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_4a733c84_8ea8_4100_afb3_432a38d24810
initial amount: NaN
has only substance units: false
name: OCRL
is encoded by: hsa:4952
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species

metaR r0603
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.12
is: SBO:0000176
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
reactant: MODEL1310110025#
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
type: Reaction
product: MODEL1310110025#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110025#_28d5e154_06bf_4f5f_9cfc_6efd55f5cd8d
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:195814
has only substance units: false
name: SDR16C5
is: B3KT84
constant: false

metaR CO2tp
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110025#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
name: CO2 peroxisomal transport
fast: false
kinetic law: MODEL1310110025#
product: MODEL1310110025#

metaM phaccoa c
boundary condition: false
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB06503
is: CHEBI:57390
notes: FORMULA: C29H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H42N7O17P3S/c1-29(2,24(40)27(41)32-9-8-19(37)31-10-11-57-20(38)12-17-6-4-3-5-7-17)14-50-56(47,48)53-55(45,46)49-13-18-23(52-54(42,43)44)22(39)28(51-18)36-16-35-21-25(30)33-15-34-26(21)36/h3-7,15-16,18,22-24,28,39-40H,8-14H2,1-2H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/p-4/t18-,22-,23-,24+,28-/m1/s1
name: phenylacetyl-CoA(4-)

metaR PROSTGF2t
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110025#
fast: false
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
product: MODEL1310110025#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
reversible: true
name: prostaglandin uniport

metaR r0480
is: SBO:0000176
fast: false
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
reversible: true
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
type: Reaction
product: MODEL1310110025#

metaM m2gacpail hs r
notes: FORMULA: C43H78NO24PFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN
type: Species
boundary condition: false
name: dimannosyl-glucosaminyl-acylphosphatidylinositol (H3)
is: SBO:0000247
is: CHEBI:16038
initial concentration: 1.0
constant: false
has only substance units: false

metaR r1467
reversible: true
product: MODEL1310110025#
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110025#
is described by: ECO:0000000
is: SBO:0000185
name: Postulated transport reaction
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110025#_933f0eb3_228d_4997_b7c4_1d838625dd6a
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:5150
has only substance units: false
type: Species
initial concentration: NaN
name: PDE7A
initial amount: NaN

metaR IMPC
modifier: MODEL1310110025#
reversible: true
kinetic law: MODEL1310110025#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 3.5.4.10 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
name: IMP cyclohydrolase
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.1.2.3
product: MODEL1310110025#

metaM xyl D c
has only substance units: false
initial concentration: 1.0
name: aldehydo-D-xylose
constant: false
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
is: CHEBI:15936
is: SBO:0000247

metaM ala L e
is: HMDB00161
has only substance units: false
boundary condition: false
name: L-alanine
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
initial amount: NaN
constant: false
is: CHEBI:16977

http://identifiers.org/biomodels.db/MODEL1310110025#_40ba53dd_be14_4f01_981e_0dd42afbd60e
type: Species
is: SBO:0000252
is encoded by: hsa:107
is: Q08828
has only substance units: false
boundary condition: true
name: ADCY1
initial concentration: NaN
initial amount: NaN
constant: false

metaM 34dhoxpeg e
is: HMDB00318
is: C05576
is: http://identifiers.org/pubchem.compound/7902
has only substance units: false
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
name: 3,4-Dihydroxyphenylethyleneglycol
notes: FORMULA: C8H10O4 CHARGE: 0 INCHI: InChI=1/C8H10O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8-12H,4H2 EHMN_ABBREVIATION: C05576
initial amount: NaN
is: SBO:0000247

metaM oxa m
initial concentration: 1.0
is: HMDB02329
is: CHEBI:30623
name: oxalate(2-)
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_7739aaa3_884e_426d_814c_59a3bcb74368
has only substance units: false
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
is: O75387
name: SLC43A1
boundary condition: true
initial amount: NaN
is encoded by: hsa:8501

metaM lnlnca c
name: alpha-linolenate
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
has only substance units: false
is: HMDB01388
initial concentration: 1.0
is: CHEBI:32387
boundary condition: false
constant: false

metaR PHETHPTOX2
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)
is: SBO:0000176
kinetic law: MODEL1310110025#
reversible: false
is version of: http://identifiers.org/ec-code/1.14.16.1
fast: false
modifier: MODEL1310110025#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5053.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.14.16.1 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:9450897 NOTES:SAB unlumped form of PHETHPTOX according to PMID 10727395
product: MODEL1310110025#
type: Reaction
reactant: MODEL1310110025#

metaM bilglcur c
initial concentration: 1.0
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
is: CHEBI:57767
name: mono(glucosyluronic acid)bilirubin(2-)
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species

metaM nh4 c
is: HMDB00051
initial concentration: 1.0
boundary condition: false
name: Ammonium
has only substance units: false
is: SBO:0000247
is: CHEBI:28938
is: C01342
constant: false
type: Species
initial amount: NaN
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342

metaM CE5786 e
name: kinetensin
is: HMDB02710
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:27485
type: Species
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_dee5d0c3_880a_4c56_9fd0_abd021e5270c
name: ABCA1
is: O95477
boundary condition: true
constant: false
is encoded by: hsa:19
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaM glyc R m
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB00139
initial amount: NaN
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
is: SBO:0000247
name: D-glycerate
has only substance units: false
constant: false
is: CHEBI:16659

metaR IMPD
kinetic law: MODEL1310110025#
name: IMP dehydrogenase
notes: GENE_ASSOCIATION: (3614.1) or (3615.1) or (3614.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.1.1.205 Confidence Level: 4 AUTHORS: PMID:16464785 NOTES:
reactant: MODEL1310110025#
type: Reaction
reversible: false
modifier: MODEL1310110025#
is: SBO:0000176
fast: false
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.1.1.205
product: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_79c7b00e_68f3_4526_bec8_33a6202038cb
constant: false
initial concentration: NaN
name: SCD
is encoded by: hsa:6319
initial amount: NaN
type: Species
boundary condition: true
is: O00767
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_8421ca24_53f4_42be_bf8f_4b02f132ad6a
boundary condition: true
constant: false
is encoded by: hsa:H77542
has only substance units: false
initial concentration: NaN
type: Species
name: _H77542_1_r
initial amount: NaN
is: SBO:0000252

metaR G6Pter
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110025#
fast: false
product: MODEL1310110025#
name: glucose 6-phosphate endoplasmic reticular transport via diffusion
reversible: true
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (2542.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11032333,PMID:11140953,PMID:11879177,PMID:9428641 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110025#

metaM xtsn c
name: xanthosine
has only substance units: false
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
is: HMDB00299
boundary condition: false
is: SBO:0000247
is: CHEBI:18107
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_7541dcbe_da53_4492_9b1d_3b81a5e83c82
name: SLCO4A1
initial concentration: NaN
is encoded by: hsa:28231
type: Species
is: Q96BD0
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false

metaR r1826
modifier: MODEL1310110025#
product: MODEL1310110025#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Y+LAT2 Utilized transport
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110025#_7e6f88c3_af27_4937_9c8f_7b20f5bb90e0
is: SBO:0000252
type: Species
has only substance units: false
name: _AA977580_1_c
constant: false
is encoded by: hsa:AA977580
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaM urate c
constant: false
initial concentration: 1.0
is: CHEBI:17775
is: HMDB00289
has only substance units: false
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
name: Urate
type: Species
boundary condition: false
initial amount: NaN
is: C00366
is: SBO:0000247

metaR EX his L LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-histidine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_cdab0db9_6f89_49a5_96e0_8e007bc743c8
is: SBO:0000252
is encoded by: hsa:9963
name: SLC23A1
initial concentration: NaN
type: Species
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN

metaM ibcoa m
has only substance units: false
initial concentration: 1.0
is: CHEBI:57338
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,34-35H,5-10H2,1-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00462 EHMN_ABBREVIATION: C00630
initial amount: NaN
is: SBO:0000247
is: HMDB01243
name: isobutyryl-CoA(4-)
constant: false
type: Species
boundary condition: false

metaR RE2625M
product: MODEL1310110025#
reversible: true
name: RE2625
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.14.13.15
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
reactant: MODEL1310110025#
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110025#

metaR r1109
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
reversible: true
kinetic law: MODEL1310110025#
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110025#
product: MODEL1310110025#

metaM arachdcoa c
constant: false
is: HMDB06523
name: arachidonoyl-CoA(4-)
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
is: CHEBI:57368
initial amount: NaN
type: Species

metaR KYNATESYN
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES:SAB name is a guess
product: MODEL1310110025#
name: 4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase
fast: false
kinetic law: MODEL1310110025#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110025#
reversible: false

metaM 3aib D c
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
is: C03265
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB02299
initial concentration: 1.0
name: D-3-Amino-isobutanoate
boundary condition: false

metaM dtdp c
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB01274
is: C00363
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
name: dTDP
initial amount: NaN
is: SBO:0000247
is: CHEBI:58369
boundary condition: false

metaM mma c
is: SBO:0000247
is: CHEBI:59338
initial amount: NaN
notes: FORMULA: C1H6N CHARGE: 1 INCHI: InChI=1S/CH5N/c1-2/h2H2,1H3/p+1 EHMN_ABBREVIATION: C00218
name: methylammonium
is: HMDB00164
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species

metaM urcan c
type: Species
is: SBO:0000247
initial amount: NaN
is: C00785
has only substance units: false
constant: false
notes: FORMULA: C6H5N2O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00534 EHMN_ABBREVIATION: C00785
is: HMDB00301
boundary condition: false
is: CHEBI:17771
initial concentration: 1.0
name: Urocanate

metaM ala L c
initial concentration: 1.0
type: Species
name: L-alanine
boundary condition: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
is: HMDB00161
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:16977

http://identifiers.org/biomodels.db/MODEL1310110025#_51264b2c_295a_46fe_96ea_a5fe8e8cb735
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:H53099
initial amount: NaN
name: _H53099_1_m
constant: false
has only substance units: false
is: SBO:0000252

metaM 5adtststerones c
boundary condition: false
name: 5alpha-Dihydrotestosterone sulfate
is: SBO:0000247
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
type: Species
initial concentration: 1.0
is: HMDB06278
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_81aca7c3_1105_42b0_a001_1ace736f370d
is encoded by: hsa:1374
boundary condition: true
is: SBO:0000252
is: Q8WZ48
type: Species
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
name: CPT1A

metaR NACHEX3ly
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110025#
fast: false
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
type: Reaction
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

metaR r1106
type: Reaction
kinetic law: MODEL1310110025#
is: SBO:0000185
product: MODEL1310110025#
name: Postulated transport reaction
reversible: true
reactant: MODEL1310110025#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

metaM bilglcur e
is: CHEBI:57767
constant: false
name: mono(glucosyluronic acid)bilirubin(2-)
initial concentration: 1.0
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaM lnlnca e
name: alpha-linolenate
initial amount: NaN
is: HMDB01388
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
is: SBO:0000247
is: CHEBI:32387
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
boundary condition: false

metaM acmana r
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB01129
is: CHEBI:17122
constant: false
name: N-acetyl-D-mannosamine
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

metaM dgdp c
is: HMDB00960
type: Species
boundary condition: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: SBO:0000247
is: C00361
initial concentration: 1.0
has only substance units: false
name: dGDP
constant: false
initial amount: NaN
is: CHEBI:58595

metaR r0403
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.4 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.2.4.4
is: SBO:0000176
product: MODEL1310110025#
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) Tryptophan metabolism EC:1.14.16.4
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#

metaM HC02204 e
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: prostaglandin-b1
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:27624
type: Species

metaR r2139
type: Reaction
reversible: true
kinetic law: MODEL1310110025#
fast: false
reactant: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110025#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

metaR HEX4
name: hexokinase (D-mannose:ATP)
reversible: false
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.7.1.2
notes: GENE_ASSOCIATION: (3098.2) or (2645.2) or (3098.3) or (2645.3) or (3098.4) or (3099.1) or (3098.5) or (3098.1) or (3101.1) or (80201.1) or (2645.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.7 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. also active in ecoli PMID: 4557975
kinetic law: MODEL1310110025#
is described by: ECO:0000304
product: MODEL1310110025#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.1
reactant: MODEL1310110025#
type: Reaction
is: SBO:0000176

metaM melatn c
initial concentration: 1.0
notes: FORMULA: C13H16N2O2 CHARGE: 0 INCHI: InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16) EHMN_ABBREVIATION: C01598
name: melatonin
boundary condition: false
is: HMDB01389
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:16796
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_12af7e02_ead2_49e6_8b64_b68eb1f13558
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:7498
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: P47989
name: XDH

metaR PI45P5P
kinetic law: MODEL1310110025#
is: SBO:0000176
reactant: MODEL1310110025#
reversible: false
modifier: MODEL1310110025#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.36
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
fast: false
product: MODEL1310110025#

metaM pmtcrn r
boundary condition: false
is: HMDB00222
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
name: L-palmitoylcarnitine
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: CHEBI:17490
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_14f61358_bc9e_4d9a_a08a_c8c54f7e28b9
initial amount: NaN
name: PLCB3
is encoded by: hsa:5331
initial concentration: NaN
is: G5E960
type: Species
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252

metaR r0545
modifier: MODEL1310110025#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
fast: false
reversible: true
product: MODEL1310110025#
kinetic law: MODEL1310110025#
type: Reaction
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/3.6.1.5

metaR ANTHte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
fast: false
name: Transport of anthranilate
product: MODEL1310110025#
is: SBO:0000185
kinetic law: MODEL1310110025#
reversible: true
reactant: MODEL1310110025#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110025#_136aff90_a898_4bc6_b3e5_3c6b6dbe0c5f
name: FDPS
is encoded by: hsa:2224
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is: P14324

metaR RE1516M
reversible: true
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
name: RE1516
is version of: http://identifiers.org/ec-code/1.3.99.13
reactant: MODEL1310110025#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
product: MODEL1310110025#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110025#_5303d72c_2fc5_4d85_b6db_f44852eea6a8
type: Species
initial amount: NaN
is encoded by: hsa:LOC727762
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
name: _LOC727762_1_m
constant: false

metaR RE2269E
type: Reaction
reversible: true
product: MODEL1310110025#
is described by: ECO:0000000
name: RE2269
is version of: http://identifiers.org/ec-code/3.4.21.39
kinetic law: MODEL1310110025#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
fast: false
reactant: MODEL1310110025#
modifier: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_8b552508_da5b_4ade_ba49_7f09dc979bc7
boundary condition: true
constant: false
name: PDE1C
is: SBO:0000252
is: Q8NB10
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:5137

http://identifiers.org/biomodels.db/MODEL1310110025#_ef80a02b_0dac_41ba_a140_aea411ac228f
is encoded by: hsa:10026
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
name: PIGK
constant: false
is: Q92643

metaM 5adtststerones e
is: HMDB06278
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
initial concentration: 1.0
is: SBO:0000247
name: 5alpha-Dihydrotestosterone sulfate
type: Species
boundary condition: false

metaM r5p c
is: SBO:0000247
is: CHEBI:18189
is: HMDB00618
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
boundary condition: false
type: Species
constant: false
initial amount: NaN
is: C00117
has only substance units: false
initial concentration: 1.0
name: alpha-D-Ribose 5-phosphate

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

metaM datp n
is: SBO:0000247
name: dATP
boundary condition: false
is: HMDB01532
constant: false
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
type: Species
initial concentration: 1.0
has only substance units: false
is: C00131
initial amount: NaN
is: CHEBI:61404

metaR r2136
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
modifier: MODEL1310110025#
product: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
type: Reaction
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110025#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110025#_88e0daba_1e57_4e4a_abab_e566960da568
is: Q5JAM2
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:211
type: Species
name: ALAS1

http://identifiers.org/biomodels.db/MODEL1310110025#_5e7ab64b_3834_46c0_a6fd_587abe914557
initial amount: NaN
name: _AI091231_1_c
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AI091231
type: Species
boundary condition: true
constant: false

metaM nadp r
constant: false
is: HMDB00217
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
boundary condition: false
type: Species
is: CHEBI:58349
name: Nicotinamide adenine dinucleotide phosphate
initial concentration: 1.0
has only substance units: false
is: C00006

metaM gdpmann c
name: GDP-alpha-D-mannose(2-)
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB01163
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
is: SBO:0000247
has only substance units: false
is: CHEBI:57527
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_ab17dcf9_4524_4167_b464_94136b27a83f
type: Species
is: Q96AT9
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: RPE
is: SBO:0000252
is encoded by: hsa:6120
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_cb0bde52_bc43_4256_8e1f_0d9649cf23ed
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AI694761
constant: false
name: _AI694761_1_c
type: Species
initial amount: NaN

metaR URCN
notes: GENE_ASSOCIATION: (131669.1) SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.49
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
reversible: false
product: MODEL1310110025#
modifier: MODEL1310110025#
fast: false
name: URCN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

metaR r0839
name: Postulated transport reaction
type: Reaction
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
modifier: MODEL1310110025#
is described by: ECO:0000000
reactant: MODEL1310110025#
reversible: true
product: MODEL1310110025#
kinetic law: MODEL1310110025#
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.70
is: SBO:0000185

metaR r0483
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110025#
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
type: Reaction
reversible: true
product: MODEL1310110025#
is: SBO:0000176
fast: false

metaR 5ADTSTSTERONEtr
product: MODEL1310110025#
is: SBO:0000185
type: Reaction
name: 5 alpha dihydrotesterone intracellular transport
fast: false
kinetic law: MODEL1310110025#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110025#
is described by: ECO:0000000

metaM cs a deg1 l
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 1
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
is: SBO:0000247
type: Species
is: CHEBI:57455
initial amount: NaN
initial concentration: 1.0
is: HMDB01354

metaR r2137
type: Reaction
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
product: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110025#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110025#

metaM HC02204 c
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: prostaglandin-b1
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
boundary condition: false
is: CHEBI:27624
is: SBO:0000247
constant: false
type: Species

metaR DMNONCRNt
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
name: 4,8 dimethylnonanoyl carnitine transport (mitochondria)
fast: false
kinetic law: MODEL1310110025#
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110025#
product: MODEL1310110025#

metaR NDP8ex
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reactant: MODEL1310110025#
name: nucleoside-diphosphatase (UTP), extracellular
fast: false
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.1.6
is: SBO:0000176
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
modifier: MODEL1310110025#
reversible: false

metaM g6p c
constant: false
is: HMDB01401
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
is: C00092
initial amount: NaN
name: D-Glucose 6-phosphate
has only substance units: false
type: Species
is: CHEBI:61548
is: SBO:0000247

metaR EX 5htrp LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5-Hydroxy-L-tryptophan exchange
type: Reaction

metaR SPH1Pte
reactant: MODEL1310110025#
name: sph1p transport
is: SBO:0000185
kinetic law: MODEL1310110025#
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
product: MODEL1310110025#
reversible: true

metaR r2416
product: MODEL1310110025#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110025#
type: Reaction
reversible: false
kinetic law: MODEL1310110025#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:8132483 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110025#_f62ba0a0_c096_4363_bddc_42590b024ba1
initial amount: NaN
is: Q9UHI7
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:9963
type: Species
name: SLC23A1

http://identifiers.org/biomodels.db/MODEL1310110025#_2ccb7219_5ca3_4d50_9ac8_51551f0139ac
constant: false
initial amount: NaN
is: Q7LG56
name: RRM2B
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:50484
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_b5605cab_86d9_4179_b0ec_6434c751a8c3
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
is: Q0VAA5
is encoded by: hsa:257068
name: PLCXD2
constant: false

metaM o2s m
type: Species
has only substance units: false
is: C00704
name: Superoxide anion
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:18421
boundary condition: false
is: HMDB02168
is: SBO:0000247
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704

metaR METtec
kinetic law: MODEL1310110025#
reversible: true
reactant: MODEL1310110025#
fast: false
product: MODEL1310110025#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
is described by: ECO:0000269
name: L-methionine transport via diffusion (extracellular to cytosol)

metaM ump c
boundary condition: false
name: UMP
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
type: Species
is: CHEBI:57865
is: C00105
is: HMDB00288
constant: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110025#_1b1b8090_db59_474f_ab5e_3882b8f40874
is encoded by: hsa:55350
has only substance units: false
has part: O95497
has part: A8K7W0
name: VNN3:VNN2:VNN1
initial concentration: NaN
boundary condition: true
is: SBO:0000297
type: Species
is encoded by: hsa:8876
is encoded by: hsa:8875
constant: false
initial amount: NaN

metaM nadp x
initial concentration: 1.0
is: HMDB00217
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
type: Species
is: CHEBI:58349
has only substance units: false
name: Nicotinamide adenine dinucleotide phosphate
is: SBO:0000247
initial amount: NaN
is: C00006
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_9495d4e9_d515_4f3e_b0db_a45f1a6e5c87
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
name: HMOX1
is: Q6FH11
is encoded by: hsa:3162
boundary condition: true
type: Species
initial amount: NaN

metaM 5mthf c
boundary condition: false
is: CHEBI:3729
notes: FORMULA: C20H24N7O6 CHARGE: -1
type: Species
is: HMDB01396
name: 5-Methyltetrahydrofolate
initial concentration: 1.0
constant: false
is: C00440
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaM acgal1p c
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:55404
is: SBO:0000247
name: N-Acetyl-D-galactosamine 1-phosphate
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6+,7-,8?/m1/s1
is: HMDB06480
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_76aae05d_f2d1_4d68_b7c1_3fcdcbc38844
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:6555
name: SLC10A2
is: Q12908
initial amount: NaN
has only substance units: false
boundary condition: true

metaR r0475
reactant: MODEL1310110025#
is described by: ECO:0000000
reversible: true
product: MODEL1310110025#
fast: false
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110025#

metaR r2347
reactant: MODEL1310110025#
product: MODEL1310110025#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110025#
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction

metaR S23Tg
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reversible: false
reactant: MODEL1310110025#
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (6482.1) or (6482.2) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:8027041 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.99.4
type: Reaction
fast: false
name: beta-galactoside alpha-2,3-sialyltransferase (T antigen)

metaM xu5p D c
has only substance units: false
initial amount: NaN
name: D-xylulose 5-phosphate(2-)
is: SBO:0000247
constant: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
is: CHEBI:57737
is: HMDB00868
initial concentration: 1.0
type: Species
boundary condition: false

metaM glyb c
is: HMDB00043
name: glycine betaine
initial concentration: 1.0
is: CHEBI:17750
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_3d22528f_a493_43a5_99ab_d3f516861c22
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:AD000092
type: Species
name: _AD000092_1_c
constant: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_8ab4a7e0_dc41_45e1_9882_8ab193a73010
constant: false
name: _AA081045_1_c
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:AA081045
initial concentration: NaN
boundary condition: true
has only substance units: false

metaM CE5236 c
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
has only substance units: false
is: SBO:0000247
name: O2'-4a-cyclic-tetrahydrobiopterin
initial amount: NaN
is: HMDB03952
is: CHEBI:28002
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_2314daa4_3c78_4cda_a8ac_b08ae843af10
is encoded by: hsa:J03866
constant: false
initial amount: NaN
boundary condition: true
name: _J03866_1_m
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species

metaM co e
initial amount: NaN
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
constant: false
is: SBO:0000247
name: carbon monoxide
initial concentration: 1.0
type: Species
is: CHEBI:17245
is: HMDB01361
boundary condition: false
has only substance units: false

metaR 34HPPte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110025#
fast: false
product: MODEL1310110025#
type: Reaction
reactant: MODEL1310110025#
reversible: true
name: Transport of 3-(4-hydroxyphenyl)pyruvate
is described by: ECO:0000134
is: SBO:0000185

metaM xmp c
name: Xanthosine 5'-phosphate
type: Species
boundary condition: false
notes: FORMULA: C10H11N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00478 EHMN_ABBREVIATION: C00655
is: C00655
is: HMDB01554
is: CHEBI:57464
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN

metaR EX cbasp LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-carbamoyl-L-aspartate
type: Reaction

metaM HC01118 r
initial concentration: 1.0
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
name: presqualene diphosphate(3-)
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:57310
type: Species
initial amount: NaN
boundary condition: false

metaR 3HKYNAKGAT
reversible: false
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
type: Reaction
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.6.1.7
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase
reactant: MODEL1310110025#
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.6.1.64
is: SBO:0000176
is described by: ECO:0000304
fast: false

http://identifiers.org/biomodels.db/MODEL1310110025#_0d9cf9a1_7411_4bb4_85f9_3bdff0c717ab
is: O43570
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: CA12
constant: false
type: Species
is encoded by: hsa:771
boundary condition: true

metaM arachd r
initial concentration: 1.0
is: HMDB01043
type: Species
name: arachidonate
is: CHEBI:32395
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN

metaR r2346
product: MODEL1310110025#
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
reversible: true
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaM ptrc e
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
is: HMDB01414
has only substance units: false
initial amount: NaN
is: C00134
initial concentration: 1.0
type: Species
is: CHEBI:326268
is: SBO:0000247
boundary condition: false
name: Putrescine
constant: false

metaM dgsn m
type: Species
boundary condition: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
is: HMDB00085
initial concentration: 1.0
is: SBO:0000247
name: Deoxyguanosine
is: C00330
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:17172

metaR EX gchola LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycocholate exchange
type: Reaction

metaR r0062
type: Reaction
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (10993.1) SUBSYSTEM: Pyruvate metabolism EC Number: 3.1.2.1 Confidence Level: 0 AUTHORS: PMID:11322891,PMID:12545200,PMID:16951743,PMID:34392,PMID:6151837,PMID:7696329 NOTES:
modifier: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000000
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/4.3.1.17
fast: false
name: Acetyl-CoA hydrolase Pyruvate metabolism EC:3.1.2.1

metaR PPItm
type: Reaction
is: SBO:0000185
name: diphopshate transporter, mitochondrial
reactant: MODEL1310110025#
is described by: ECO:0000134
product: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
reversible: true
kinetic law: MODEL1310110025#

metaR PROSTGD2t
fast: false
reactant: MODEL1310110025#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
kinetic law: MODEL1310110025#
type: Reaction
name: prostaglandin transport via bicarbonate countertransport
modifier: MODEL1310110025#
is: SBO:0000185
reversible: true
product: MODEL1310110025#

metaR 3HCO3 NAt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
reactant: MODEL1310110025#
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110025#
name: 3HCO3_NAt
is described by: ECO:0000134
product: MODEL1310110025#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_63648567_4758_4fca_a2e9_40fe825d8099
type: Species
initial amount: NaN
boundary condition: true
name: SLC5A2
constant: false
is: P31639
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6524
is: SBO:0000252

metaR PETOHMm hs
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reversible: false
reactant: MODEL1310110025#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-prot] NJ
is version of: http://identifiers.org/ec-code/2.1.1.17
modifier: MODEL1310110025#
name: phosphatidylethanolamine N-methyltransferase
fast: false
is described by: ECO:0000254
type: Reaction

metaM arachcrn c
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
is: SBO:0000247
is: HMDB06460
name: arachidyl carnitine
initial concentration: 1.0
type: Species
boundary condition: false

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_cd9b8c3f_2aa2_4236_b63f_3ed2846712dd
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is: D3DTL2
name: ENO3
initial amount: NaN
is encoded by: hsa:2027

metaR URAt
name: uracil transport via facilated diffusion
modifier: MODEL1310110025#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
is described by: ECO:0000269
fast: false
type: Reaction
product: MODEL1310110025#

metaM ade c
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
is: HMDB00034
boundary condition: false
constant: false
name: Adenine
initial amount: NaN
type: Species
is: C00147
is: CHEBI:16708
initial concentration: 1.0

metaR GCCbim
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/1.4.4.2
name: glycine-cleavage complex (lipoylprotein) irreversible, mitochondrial
is version of: http://identifiers.org/ec-code/2.1.2.10
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
fast: false
type: Reaction
is: SBO:0000176

metaM b2coa m
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
is: CHEBI:57332
boundary condition: false
is: HMDB02009
is: SBO:0000247
name: crotonoyl-CoA(4-)
constant: false

metaM 2mop m
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB01172
constant: false
is: CHEBI:57700
initial concentration: 1.0
name: 2-methyl-3-oxopropanoate
type: Species
has only substance units: false

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

metaM 3odcoa m
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
is: SBO:0000247
constant: false
is: CHEBI:28528
initial amount: NaN
name: 3-Oxodecanoyl-CoA
is: HMDB03939

metaR EX 10fthf LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-Formyltetrahydrofolate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_201db0fe_4c7a_4a61_8568_c4bf0bc390e2
has only substance units: false
is encoded by: hsa:6576
constant: false
type: Species
is: SBO:0000252
name: SLC25A1
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: D9HTE9

http://identifiers.org/biomodels.db/MODEL1310110025#_37ebd27f_9855_419f_849f_1fea997324f9
boundary condition: true
initial concentration: NaN
has only substance units: false
name: GNE
initial amount: NaN
is: B7Z428
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:10020

metaM ach e
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:15355
constant: false
initial amount: NaN
is: SBO:0000247
name: acetylcholine
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
is: HMDB00895
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110025#_1e983107_258b_4bcb_835e_3a8876e6bca6
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
is: O14975
is encoded by: hsa:11001
initial concentration: NaN
name: SLC27A2
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110025#_f63572e8_1172_4a83_9fbd_ea67acaddb9d
is encoded by: hsa:6713
boundary condition: true
name: SQLE
type: Species
has only substance units: false
initial concentration: NaN
is: Q5HYI4
constant: false
is: SBO:0000252
initial amount: NaN

metaM dolp U r
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:57683
name: dolichyl phosphate(2-)
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110

metaM co c
is: SBO:0000247
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:17245
is: HMDB01361
initial concentration: 1.0
name: carbon monoxide
constant: false

metaM thymd e
is: C00214
is: HMDB00273
initial amount: NaN
initial concentration: 1.0
name: Thymidine
is: CHEBI:17748
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
constant: false

metaM crn c
is: CHEBI:16347
initial amount: NaN
is: HMDB00062
name: L-Carnitine
boundary condition: false
has only substance units: false
constant: false
is: C00318
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318

metaR r0287
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110025#
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
type: Reaction
modifier: MODEL1310110025#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
fast: false

metaR TMNDNCCOAtx
reactant: MODEL1310110025#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
kinetic law: MODEL1310110025#
is described by: ECO:0000000
name: fatty acid intracellular transport
product: MODEL1310110025#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110025#_b5bc4d64_2e6b_4661_b89f_d25132723fea
constant: false
is: Q9HBF5
boundary condition: true
initial amount: NaN
is encoded by: hsa:400410
is: SBO:0000252
name: ST20
initial concentration: NaN
type: Species
has only substance units: false

metaM ptrc c
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB01414
is: C00134
type: Species
initial amount: NaN
is: CHEBI:326268
boundary condition: false
name: Putrescine
is: SBO:0000247
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134

metaM pre prot r
notes: FORMULA: XY CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
name: glycophosphatidylinositol (GPI)-anchored protein precursor
type: Species
has only substance units: false
is: CHEBI:16038

metaR TYRTA
is version of: http://identifiers.org/ec-code/2.6.1.1
fast: false
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
is described by: ECO:0000269
name: tyrosine transaminase
is: SBO:0000176
reactant: MODEL1310110025#
modifier: MODEL1310110025#
product: MODEL1310110025#
reversible: true
kinetic law: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_c44daa7c_d10e_425e_9d6c_c2436aeab42f
boundary condition: true
is: P48651
is encoded by: hsa:9791
type: Species
has only substance units: false
name: PTDSS1
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_aaa26bb5_2124_4f58_b210_d975db04a196
has only substance units: false
is: SBO:0000252
name: AK7
initial amount: NaN
is encoded by: hsa:122481
initial concentration: NaN
boundary condition: true
type: Species
is: Q96M32
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_3930547e_2843_42cc_804f_6f157f88e67e
name: _U37519_1_e
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:U37519

metaR OCDCAtr
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
reactant: MODEL1310110025#
type: Reaction
name: fatty acid transport via diffusion
reversible: true

metaM gthox c
is: HMDB03337
constant: false
boundary condition: false
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
is: SBO:0000247
name: Oxidized glutathione
is: C00127
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:58297

metaR DCYTD
fast: false
name: deoxycytidine deaminase
modifier: MODEL1310110025#
product: MODEL1310110025#
reversible: false
notes: GENE_ASSOCIATION: (978.1) or (57379.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:14744791,PMID:15087440,PMID:7923172,PMID:8001985,PMID:8422236 NOTES:
reactant: MODEL1310110025#
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.5
is described by: ECO:0000254
is: SBO:0000176
kinetic law: MODEL1310110025#

metaM mthgxl c
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:17158
has only substance units: false
initial amount: NaN
name: methylglyoxal
is: HMDB01167

http://identifiers.org/biomodels.db/MODEL1310110025#_9d18d1e1_d2b3_4792_9e21_78b871908e6c
initial concentration: NaN
name: HSD3B2
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:3284
is: P26439
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR r2420
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110025#
reactant: MODEL1310110025#
fast: false
kinetic law: MODEL1310110025#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110025#_51e1c57d_3b23_4755_b9e5_d6a755644754
is: Q8NFW8
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:55907
name: CMAS
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_7a2a3040_e919_4277_8606_d86a5221ae75
is: SBO:0000252
has only substance units: false
is: O95263
initial amount: NaN
type: Species
constant: false
name: PDE8B
is encoded by: hsa:8622
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_1aad4800_9458_49bb_8b0d_1d0a78161094
name: ALPP
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:250
is: P05187
is: SBO:0000252
constant: false
type: Species
boundary condition: true

metaM ade e
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
is: HMDB00034
initial amount: NaN
is: CHEBI:16708
boundary condition: false
name: adenine
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147

http://identifiers.org/biomodels.db/MODEL1310110025#_7f4d60a4_f2db_45db_8ccc_4dd26f3c36ab
initial amount: NaN
type: Species
constant: false
boundary condition: true
has only substance units: false
name: CYB5D1
is encoded by: hsa:124637
initial concentration: NaN
is: Q6P9G0
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110025#_a72a4065_8a1d_4d48_a754_3cc53a0c421d
type: Species
boundary condition: true
is: E9PB82
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3295
name: HSD17B4
constant: false
is: SBO:0000252
has only substance units: false

metaM tdchola e
type: Species
boundary condition: false
initial amount: NaN
is: HMDB00951
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:9407
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
constant: false
name: taurochenodeoxycholate

metaR CYSGLUexR
product: MODEL1310110025#
is: SBO:0000185
type: Reaction
name: L-cysteine/L-glutamine reversible exchanger
reactant: MODEL1310110025#
modifier: MODEL1310110025#
reversible: true
kinetic law: MODEL1310110025#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false

metaM tsul m
constant: false
is: HMDB00257
name: thiosulfate(2-)
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:16094
is: SBO:0000247
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320

metaR MERCPLACCYSt
is: SBO:0000185
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:excretion of 3-mercaptolactate-cysteine disulfide (PMID: 6945862) MM
fast: false
is described by: ECO:0000000
type: Reaction
name: 3-mercaptolactate-cysteine disulfide transport, extracellular
reversible: false
product: MODEL1310110025#

metaR FAEL183
fast: false
type: Reaction
name: fatty-acyl-CoA elongation (n-C18:3CoA)
product: MODEL1310110025#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110025#
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ

metaR DNDPt27m
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
modifier: MODEL1310110025#
name: dCDP transport via dTDP antiport
product: MODEL1310110025#
reversible: false
fast: false
is: SBO:0000185
reactant: MODEL1310110025#
is described by: ECO:0000269

metaM pro L c
is: SBO:0000247
is: HMDB00162
type: Species
initial amount: NaN
is: CHEBI:17203
has only substance units: false
name: L-proline
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145

metaM HC01231 m
has only substance units: false
initial concentration: 1.0
is: CHEBI:58480
boundary condition: false
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
initial amount: NaN
name: N-[(R)-pantothenoyl]-L-cysteinate

metaM dutp m
is: CHEBI:17625
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
has only substance units: false
boundary condition: false
is: HMDB01191
initial concentration: 1.0
name: dUTP
constant: false
type: Species
is: SBO:0000247
initial amount: NaN

metaR AMANK
fast: false
is version of: http://identifiers.org/ec-code/5.1.3.14
reactant: MODEL1310110025#
name: N-acetyl-D-mannosamine kinase
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (10020.1) or (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.60 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835,PMID:11308027 NOTES:JLR - Kegg R02705
modifier: MODEL1310110025#
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110025#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.59
type: Reaction

metaM 5mthf e
has only substance units: false
type: Species
is: HMDB01396
is: CHEBI:3729
is: C00440
name: 5-Methyltetrahydrofolate
boundary condition: false
constant: false
notes: FORMULA: C20H24N7O6 CHARGE: -1
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaR APOCFm
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:IT faked reaction to balance reaction in human biotin metabolism
fast: false
name: Apocarboxylase formation, mitochondrial
reactant: MODEL1310110025#
product: MODEL1310110025#
kinetic law: MODEL1310110025#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_8aa1f66f_528b_4a06_b6f0_3487d4740ddc
is: SBO:0000252
is encoded by: hsa:767
type: Species
name: CA8
constant: false
is: P35219
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR DAGt
is described by: ECO:0000269
reversible: true
name: diacylglycerol transport
product: MODEL1310110025#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.1.107 Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
fast: false
type: Reaction

metaR BTNt4i
reversible: false
reactant: MODEL1310110025#
name: Biotin uptake (antiport)
is: SBO:0000185
product: MODEL1310110025#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
kinetic law: MODEL1310110025#

metaM thbpt4acam c
initial concentration: 1.0
is: SBO:0000247
is: HMDB02281
constant: false
type: Species
name: 4a-hydroxytetrahydrobiopterin
initial amount: NaN
has only substance units: false
is: CHEBI:15374
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110025#_8d499f82_79a8_4dbc_85b5_f94a28c01341
is: SBO:0000252
type: Species
name: PLCB1
is encoded by: hsa:23236
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false

metaM xoldiolone c
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
is: HMDB02197
type: Species
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
is: CHEBI:28477

http://identifiers.org/biomodels.db/MODEL1310110025#_d0462f29_8e67_43ee_89c2_e1c4d1bfc789
initial amount: NaN
name: DLAT
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1737
constant: false
type: Species
is: SBO:0000252
is: Q86YI5

http://identifiers.org/biomodels.db/MODEL1310110025#_0b0c5c5f_203e_4c92_975e_895f5bac964a
name: _LOC728997_1_c
initial concentration: NaN
constant: false
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:LOC728997
initial amount: NaN

metaR GGH 10FTHF5GLUe
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.4.19.9
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
name: Gamma-glutamyl hydrolase (10FTHF5GLU), extracellular
product: MODEL1310110025#

metaM ump e
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: HMDB00288
name: UMP(2-)
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:57865
constant: false

metaR FACOAL40im
notes: GENE_ASSOCIATION: (116285.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: PMID:11470804,PMID:3297476 NOTES:JLR changed EC from 6.2.1.3 (long chain fatty-acyl CoA ligase) to 6.2.1.2 (butyrate-CoA ligase) - NCD
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
fast: false
reactant: MODEL1310110025#
reversible: false
product: MODEL1310110025#
name: fatty-acid--CoA ligase (butanoate), mitochondrial
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/6.2.1.2

http://identifiers.org/biomodels.db/MODEL1310110025#_7a6497c7_ab62_4135_959e_ff3dd468a9c9
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4731
constant: false
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
is: P56181
name: NDUFV3

metaM tcynt e
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
type: Species
is: CHEBI:18022
name: thiocyanate
has only substance units: false
initial concentration: 1.0
is: HMDB01453
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110025#_a57b443b_77b4_4d49_bd89_d15f5fefdcca
boundary condition: true
is encoded by: hsa:11332
name: ACOT7
initial concentration: NaN
is: O00154
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_e066a068_0935_4242_a341_f8a4225e8d8c
constant: false
name: SLC3A1
is: SBO:0000252
type: Species
is encoded by: hsa:6519
initial concentration: NaN
has only substance units: false
boundary condition: true
is: Q07837
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_7ab8ffd0_d641_4aaa_b9db_5b67b9bab3e1
is: SBO:0000252
has only substance units: false
name: HAS1
is encoded by: hsa:3036
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
type: Species
is: Q8IYH3

metaM tdchola c
is: HMDB00951
is: SBO:0000247
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:9407
name: taurochenodeoxycholate
type: Species
has only substance units: false

metaM pro L e
is: HMDB00162
initial amount: NaN
type: Species
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: CHEBI:17203
constant: false
name: L-proline
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaM 5HPET c
is: SBO:0000247
is: HMDB01193
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
is: CHEBI:57450
name: 5(S)-HPETE(1-)
boundary condition: false
constant: false

metaR r1453
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
is described by: ECO:0000000
product: MODEL1310110025#
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
is: SBO:0000176

metaR EX eicostet LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: eicosatetranoic acid exchange
type: Reaction

metaM prostgd2 r
is: CHEBI:57406
initial amount: NaN
has only substance units: false
name: prostaglandin D2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: HMDB01403
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247

metaR r1620
is: SBO:0000185
reversible: true
reactant: MODEL1310110025#
modifier: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000000
type: Reaction

metaM CE2839 e
constant: false
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
initial amount: NaN
is: C01936
name: maltodecaose
is: http://identifiers.org/pubchem.compound/5041
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false

metaR ASNtN1
reactant: MODEL1310110025#
is: SBO:0000185
product: MODEL1310110025#
kinetic law: MODEL1310110025#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
name: Asparagine transport (Na, H coupled)
reversible: true
modifier: MODEL1310110025#
fast: false

metaM 3ohdcoa m
is: SBO:0000247
type: Species
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:57349
name: 3-oxopalmitoyl-CoA(4-)
is: HMDB06402
initial concentration: 1.0
constant: false

metaM xoldiolone r
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
is: HMDB02197
constant: false
has only substance units: false
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
is: CHEBI:28477

metaR OAADC
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: oxaloacetate decarboxylase
type: Reaction

metaM thbpt4acam n
type: Species
constant: false
name: 4a-hydroxytetrahydrobiopterin
is: HMDB02281
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
is: CHEBI:15374
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaR PPItx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
fast: false
product: MODEL1310110025#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
type: Reaction
name: Diphosphate transporter, peroxisome
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110025#_b86538e8_2a56_48f9_8eab_1fdf45f6acc7
name: ABP1
type: Species
initial amount: NaN
constant: false
is: P19801
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:26

metaR G6PDA
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reactant: MODEL1310110025#
modifier: MODEL1310110025#
name: glucosamine-6-phosphate deaminase
fast: false
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.99.6
reversible: false
notes: GENE_ASSOCIATION: (132789.1) or (10007.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.5.99.6 Confidence Level: 4 AUTHORS: PMID:9714720 NOTES:Previously EC 5.3.1.10
type: Reaction

metaR GUAPRT
fast: false
type: Reaction
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine and 6-mercaptopurine can replace hypoxanthine EC added (2.4.2.7 makes the same reaction) IT
product: MODEL1310110025#
reversible: false
name: guanine phosphoribosyltransferase
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.8
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#

metaM o2s e
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB02168
is: CHEBI:18421
name: superoxide

http://identifiers.org/biomodels.db/MODEL1310110025#_f3ca05ff_619f_4fd5_b4c6_498f4a6d0396
is: SBO:0000252
is encoded by: hsa:226
name: ALDOA
type: Species
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR r1621
is: SBO:0000185
modifier: MODEL1310110025#
is described by: ECO:0000000
reactant: MODEL1310110025#
type: Reaction
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_83be6948_b25e_4beb_999f_5bd3306503f6
initial concentration: NaN
is encoded by: hsa:57282
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
is: B7Z1R0
name: SLC4A10
type: Species

metaR r1561
fast: false
kinetic law: MODEL1310110025#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110025#
reactant: MODEL1310110025#
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110025#_c60e9889_0e26_488e_bae2_d0c592dc038e
is encoded by: hsa:PRO1933
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
name: _PRO1933_1_m

metaR DOLK U
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.7.1.108 Confidence Level: 0 AUTHORS: NOTES:
name: Dolichol kinase, human (uterus)
kinetic law: MODEL1310110025#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110025#
is: SBO:0000176
reversible: false
fast: false

metaM 2dr1p c
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
name: 2-Deoxy-D-ribose 1-phosphate
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
initial concentration: 1.0
is: C00672
is: HMDB01351
has only substance units: false
constant: false
is: CHEBI:58576

metaR GLYATm
product: MODEL1310110025#
kinetic law: MODEL1310110025#
fast: false
is described by: ECO:0000254
type: Reaction
modifier: MODEL1310110025#
reversible: true
name: glycine C-acetyltransferase
is version of: http://identifiers.org/ec-code/2.3.1.29
notes: GENE_ASSOCIATION: (23464.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.29 Confidence Level: 2 AUTHORS: PMID:10712613 NOTES:
is: SBO:0000176
reactant: MODEL1310110025#

metaR MI14P4P
reversible: false
kinetic law: MODEL1310110025#
name: inositol-1,4-bisphosphate 4-phosphatase
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110025#
type: Reaction
reactant: MODEL1310110025#
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110025#_c35511b9_ee7c_4992_9e5b_440514dcfec1
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
name: ALDH3B2
constant: false
is: P48448
is encoded by: hsa:222
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110025#_035082e1_0e0c_4462_b1ce_4319538fa23a
is encoded by: hsa:5831
type: Species
is: P32322
has only substance units: false
is: SBO:0000252
boundary condition: true
name: PYCR1
initial concentration: NaN
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_488c91e2_6c95_483b_a35a_f7e36580c565
initial amount: NaN
name: ADCY5
has only substance units: false
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:111
boundary condition: true
is: O95622

http://identifiers.org/biomodels.db/MODEL1310110025#_368640e7_9905_4ff3_a806_21e572f82571
type: Species
initial amount: NaN
is encoded by: hsa:7296
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
name: TXNRD1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_77450060_8332_4f51_808b_f98f896d09ac
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:123041
type: Species
is: SBO:0000252
initial amount: NaN
name: SLC24A4

metaR PGK
is described by: ECO:0000134
reversible: true
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (5230.1) or (375056.1) or (5232.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
name: phosphoglycerate kinase
reactant: MODEL1310110025#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.2.3
modifier: MODEL1310110025#
product: MODEL1310110025#
fast: false

metaR r1260
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is: SBO:0000176
reactant: MODEL1310110025#
reversible: false
product: MODEL1310110025#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110025#
name: EC:6.2.1.3
type: Reaction

metaM dmnoncrn m
notes: FORMULA: C18H37NO4 CHARGE: 0 INCHI: InChI=1/C18H35NO4/c1-14(2)8-7-9-15(3)10-11-18(22)23-16(12-17(20)21)13-19(4,5)6/h14-16H,7-13H2,1-6H3
type: Species
name: 4,8 dimethylnonanoyl carnitine
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB06202
initial amount: NaN
is: SBO:0000247

metaR r1622
reversible: true
kinetic law: MODEL1310110025#
is: SBO:0000185
reactant: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
modifier: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction

metaR r1560
reactant: MODEL1310110025#
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110025#
product: MODEL1310110025#

metaM dgsn e
boundary condition: false
is: C00330
constant: false
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
name: Deoxyguanosine
is: CHEBI:17172
is: HMDB00085
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
initial amount: NaN

metaM tcynt c
is: CHEBI:18022
name: thiocyanate
initial concentration: 1.0
is: HMDB01453
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
constant: false
has only substance units: false

metaM C02470 c
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB00881
type: Species
is: SBO:0000247
is: C02470
initial amount: NaN
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
name: Xanthurenic acid
constant: false
is: http://identifiers.org/pubchem.compound/5485

metaR DURIt
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
product: MODEL1310110025#
reactant: MODEL1310110025#
type: Reaction
name: deoxyuridine transport via diffusion
kinetic law: MODEL1310110025#
reversible: true
is described by: ECO:0000000
fast: false

metaR 3AIB Dtm
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: no transporter could be identified, so diffusion is assumed. NOTES:
fast: false
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
name: transport of 3aib_D into mitochondria
is described by: ECO:0000134
product: MODEL1310110025#

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_016d6426_2573_499a_8a8d_fef3167f14a8
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3990
is: A6H8L5
name: LIPC
constant: false

metaR MANt4
kinetic law: MODEL1310110025#
reversible: true
name: D-mannose transport via sodium cotransport
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
is: SBO:0000185
product: MODEL1310110025#
is described by: ECO:0000269
reactant: MODEL1310110025#
fast: false
type: Reaction
modifier: MODEL1310110025#

metaM cs a deg4 l
notes: FORMULA: C31H49NO29S CHARGE: -2
initial concentration: 1.0
is: SBO:0000247
is: HMDB01354
constant: false
has only substance units: false
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 4
boundary condition: false
type: Species
is: CHEBI:57455
initial amount: NaN

metaR ACOAO7p
is version of: http://identifiers.org/ec-code/1.3.3.6
reversible: false
product: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: (51.1) or (51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: PMID:7876265,PMID:8159712 NOTES:NCD
name: acyl-CoA oxidase (hexadecanoyl-CoA), peroxisomal
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
modifier: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_3179e56b_9c13_4122_980f_ff6a276162f2
name: LDHC
has only substance units: false
is: P07864
is encoded by: hsa:3948
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
constant: false

metaR PROSTGH2t
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
is described by: ECO:0000269
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110025#
fast: false
name: Prostaglandin H2 transport
product: MODEL1310110025#
type: Reaction

metaR LTD4DP
type: Reaction
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
fast: false
is described by: ECO:0000000
reactant: MODEL1310110025#
product: MODEL1310110025#
name: Leukotriene D4 dipeptidase
kinetic law: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_552be244_8316_4f02_85d8_490777ac38e2
type: Species
initial concentration: NaN
is: P15954
is encoded by: hsa:1350
has only substance units: false
name: COX7C
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR r2341
reactant: MODEL1310110025#
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110025#
type: Reaction
is described by: ECO:0000000

metaM 5pmev c
is: HMDB01343
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H10O7P CHARGE: -3 INCHI: InChI=1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/p-3/t6-/m1/s1
initial amount: NaN
has only substance units: false
name: (R)-5-phosphonatomevalonate(3-)

metaR r0830
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
modifier: MODEL1310110025#
is: SBO:0000185
product: MODEL1310110025#
reversible: true
kinetic law: MODEL1310110025#
fast: false
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/3.5.4.16

metaR r1563
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110025#
is: SBO:0000185
type: Reaction
fast: false

metaR 5HTRPVESSEC
kinetic law: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: (6570.1) or (6571.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827358,PMID:15383652 NOTES:SAB This reaction represents the ATP driven secretion of 5htrp from the cell. It leaves out the vesicle because that is not a compartment. ATP:H ratio is assumed as 1:3 for vacuolar ATPase and substrate:h ratio is 1:2. This gives a 3:2 ratio for substrate:ATP
modifier: MODEL1310110025#
name: 5-hydroxy-L-tryptophan secretion via secretory vesicle (ATP driven)
fast: false
product: MODEL1310110025#
is: SBO:0000185
reactant: MODEL1310110025#
is described by: ECO:0000269
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110025#_0804e527_a69d_460a_b426_671ac092ea71
is: O95498
has only substance units: false
initial amount: NaN
name: VNN2
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:8875

metaR TAURCHAe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14992263 NOTES:taurine is an osmolyte that aids in osmoregulation. Reactive oxygen species (ROS) and eicosanoids activate tyrosine-kinase cascade, resulting in activation of volume sensitive taurine channel. Further ROS causes membrane permeabilization that results in taruine loss.
name: exit of taurine from the enterocytes
kinetic law: MODEL1310110025#
is described by: ECO:0000134
type: Reaction
product: MODEL1310110025#
is: SBO:0000185
reversible: false
fast: false
reactant: MODEL1310110025#

metaR r1623
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110025#
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110025#
fast: false
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_8b11028e_f203_40fb_9d79_35cbb17db28e
type: Species
initial amount: NaN
is: SBO:0000252
name: SLC34A2
boundary condition: true
initial concentration: NaN
is encoded by: hsa:10568
is: O95436
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_1114fac9_da02_411d_88f4_9354ac682897
constant: false
type: Species
name: TREH
initial concentration: NaN
is: O43280
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:11181

metaM dudp c
is: SBO:0000247
is: C01346
name: dUDP
is: CHEBI:60471
boundary condition: false
initial concentration: 1.0
is: HMDB01000
constant: false
initial amount: NaN
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
has only substance units: false
type: Species

metaR LYStip
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:6811962 NOTES:MM
kinetic law: MODEL1310110025#
reversible: false
reactant: MODEL1310110025#
name: L-lysine transport, peroxisomal (irreversible)
type: Reaction

metaR PGI
name: glucose-6-phosphate isomerase
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:
is version of: http://identifiers.org/ec-code/5.3.1.9
fast: false
reversible: true
reactant: MODEL1310110025#
type: Reaction
is: SBO:0000176

metaM zymstnl r
initial amount: NaN
type: Species
is: HMDB06841
boundary condition: false
name: 5alpha-cholest-8-en-3beta-ol
initial concentration: 1.0
constant: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
is: SBO:0000247
is: CHEBI:16608
has only substance units: false

metaR r1562
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
product: MODEL1310110025#

metaM arachd l
initial amount: NaN
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
boundary condition: false
name: arachidonate
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
is: HMDB01043
is: CHEBI:32395
has only substance units: false

metaM HC01231 c
is: CHEBI:58480
name: N-[(R)-pantothenoyl]-L-cysteinate
initial amount: NaN
boundary condition: false
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
type: Species
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaM tsul c
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
initial amount: NaN
type: Species
is: CHEBI:16094
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB00257
boundary condition: false
has only substance units: false
name: thiosulfate(2-)

metaR DGTPtn
type: Reaction
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
fast: false
name: dGTP diffusion in nucleus
product: MODEL1310110025#

metaR MACOXO
type: Reaction
notes: GENE_ASSOCIATION: (218.1) or (221.1) or (4129.1) or (222.1) or (220.1) SUBSYSTEM: Histidine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10344773 NOTES:SAB added 2 h to balance--not certain
fast: false
reversible: false
modifier: MODEL1310110025#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.4.3.4
kinetic law: MODEL1310110025#
name: 3-Methylimidazole acetaldehyde:NAD+ oxidoreductase
product: MODEL1310110025#
reactant: MODEL1310110025#

metaR r1624
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110025#
fast: false
kinetic law: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110025#
reversible: true
type: Reaction
modifier: MODEL1310110025#
is described by: ECO:0000000

metaM prostgd2 e
is: HMDB01403
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
constant: false
name: prostaglandin D2(1-)
initial concentration: 1.0
is: CHEBI:57406

metaM acgam l
has only substance units: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
initial amount: NaN
name: N-acetyl-D-glucosamine
is: SBO:0000247
type: Species
constant: false
is: HMDB00215
initial concentration: 1.0
boundary condition: false
is: CHEBI:17411

metaR CMPACNAtn
fast: false
reversible: false
is described by: ECO:0000000
type: Reaction
name: CMP-Sia nuclear export
product: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_d1dd581d_04f1_4367_9380_7e926d171538
has only substance units: false
name: PPAP2C
is: SBO:0000252
is: E9PAY8
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:8612
boundary condition: true

metaM thymd m
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: Thymidine
is: CHEBI:17748
is: HMDB00273
type: Species
is: C00214
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
constant: false
is: SBO:0000247
boundary condition: false

metaM dgsn c
initial amount: NaN
boundary condition: false
is: C00330
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
name: Deoxyguanosine
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
is: HMDB00085
is: CHEBI:17172

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_42bad227_149a_47f0_9d57_1d2c4acc1eb4
name: CYP8B1
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
boundary condition: true
is encoded by: hsa:1582
is: Q9UNU6
is: SBO:0000252
has only substance units: false

metaM arachcrn m
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: arachidyl carnitine
is: HMDB06460
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_f36ce1b6_93a5_4926_96d3_00053ae1270d
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is: Q7GXZ8
is: SBO:0000252
name: COX2
is encoded by: hsa:4513
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_fea00ba9_fb3b_4a3d_a5ef_5e7a89878530
is encoded by: hsa:56606
initial concentration: NaN
is: Q9NRM0
name: SLC2A9
constant: false
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true

metaM arachd e
name: arachidonate
constant: false
has only substance units: false
is: HMDB01043
is: SBO:0000247
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
type: Species
is: CHEBI:32395
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaR HAS2
is version of: http://identifiers.org/ec-code/2.4.1.212
reactant: MODEL1310110025#
is: SBO:0000185
product: MODEL1310110025#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
reversible: false
name: hyaluronan synthase
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_5b9a8c72_841a_44ac_8e0c_823dceb65f54
boundary condition: true
is encoded by: hsa:5151
is: SBO:0000252
initial concentration: NaN
name: PDE8A
has only substance units: false
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_1e6a23dc_c275_40d8_b643_0e414fec1e6a
is encoded by: hsa:411
constant: false
type: Species
is: A8K4A0
boundary condition: true
name: ARSB
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110025#_1a0324d6_f347_4170_a655_b5d10a2c60ff
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:1103
name: CHAT
is: D3DX95
initial amount: NaN
has only substance units: false

metaR NH4tp
kinetic law: MODEL1310110025#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: ammonia peroxisomal transport
product: MODEL1310110025#
is: SBO:0000185
fast: false
reactant: MODEL1310110025#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_9e10213b_0b69_4372_b472_554aafd23552
constant: false
is encoded by: hsa:1468
name: SLC25A10
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q9UBX3
has only substance units: false
type: Species
initial concentration: NaN

metaM CE5236 n
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
is: HMDB03952
name: O2'-4a-cyclic-tetrahydrobiopterin
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
initial concentration: 1.0
type: Species
is: CHEBI:28002

http://identifiers.org/biomodels.db/MODEL1310110025#_c8767e00_d347_492c_8373_ebc2a5b6330c
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
is: Q8TCD5
is encoded by: hsa:30833
name: NT5C
has only substance units: false
boundary condition: true

metaR P4501B1r
kinetic law: MODEL1310110025#
is: SBO:0000176
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.14.14.1
name: cytochrome P450 1B1
modifier: MODEL1310110025#
type: Reaction
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: (1545.1) SUBSYSTEM: Steroid metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15579107,PMID:8910454 NOTES:_4 hydroxylation of 17 beta estradiol NJ

metaM 2mop c
is: HMDB01172
type: Species
name: 2-methyl-3-oxopropanoate
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:57700

metaM 4hphac c
type: Species
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
is: HMDB00020
is: CHEBI:48999
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
is: SBO:0000247
name: 4-hydroxyphenylacetate
initial concentration: 1.0

metaM i e
is: CHEBI:16382
boundary condition: false
constant: false
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB12238
type: Species
name: iodide
is: SBO:0000247

metaM gdp e
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
has only substance units: false
is: CHEBI:58189
boundary condition: false
constant: false
name: GDP(3-)
is: HMDB01201

http://identifiers.org/biomodels.db/MODEL1310110025#_f1a4ccd4_8c3c_4728_bd8b_a861cbe3faf3
initial amount: NaN
name: ALDH3A1
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:218
constant: false
is: P30838
type: Species
has only substance units: false

metaM thyox L c
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
is: HMDB00248
is: CHEBI:18332
initial amount: NaN
constant: false
name: L-thyroxine
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species

metaR CSND
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.1 Confidence Level: 2 AUTHORS: NOTES:JLR. Part of a famous suicide gene combination with 5-fluorocytosine
name: Cytosine deaminase
reversible: false
product: MODEL1310110025#
is described by: ECO:0000000
reactant: MODEL1310110025#
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110025#

metaR r1625
is described by: ECO:0000000
product: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110025#
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
fast: false
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#

metaR GAPD
is described by: ECO:0000134
type: Reaction
fast: false
modifier: MODEL1310110025#
reversible: true
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.
name: glyceraldehyde-3-phosphate dehydrogenase
is: SBO:0000176
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.2.1.12
product: MODEL1310110025#

metaM amet c
boundary condition: false
has only substance units: false
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: HMDB01185
constant: false
name: S-Adenosyl-L-methionine
type: Species
is: C00019
initial amount: NaN
is: CHEBI:15414
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110025#_be820958_a2e2_4bed_b9e9_caa5f489f581
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: Q63HM1
name: AFMID
is encoded by: hsa:125061
constant: false
boundary condition: true

metaR r1050
kinetic law: MODEL1310110025#
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
name: Vesicular transport
is: SBO:0000185
product: MODEL1310110025#
reactant: MODEL1310110025#

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

metaR r2068
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110025#
is: SBO:0000185
fast: false
modifier: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110025#

metaR ARACHCPT1
type: Reaction
is: SBO:0000176
reversible: false
product: MODEL1310110025#
is described by: ECO:0000000
name: carnitine transferase
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (1375.3) or (1374.1) or (1375.2) or (1375.4) or (1375.1) or (126129.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#

metaR RETH2e
reversible: false
kinetic law: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000000
fast: false
name: retinyl ester hydrolase (11-cis), extracellular
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reactant: MODEL1310110025#
type: Reaction

metaR PPItr
fast: false
reversible: true
reactant: MODEL1310110025#
is: SBO:0000185
name: Diphosphate transporter, endoplasmic reticulum
kinetic law: MODEL1310110025#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ

metaM pail hs c
constant: false
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
name: 1-phosphatidyl-1D-myo-inositol(1-)
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:57880

metaR r1626
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110025#
product: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110025#
reversible: true
type: Reaction
modifier: MODEL1310110025#
is described by: ECO:0000000
is: SBO:0000185

metaM acgam r
initial concentration: 1.0
is: HMDB00215
name: N-acetyl-D-glucosamine
is: CHEBI:17411
has only substance units: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
constant: false
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaM ach c
constant: false
boundary condition: false
initial amount: NaN
type: Species
name: acetylcholine
is: CHEBI:15355
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
is: HMDB00895
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaR BUTt2m
reversible: true
type: Reaction
reactant: MODEL1310110025#
modifier: MODEL1310110025#
is: SBO:0000185
kinetic law: MODEL1310110025#
product: MODEL1310110025#
fast: false
name: Butyrate mitochondrial transport via proton symport, reversible
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110025#_85bb8961_5d5c_402a_9e7d_fb30a4e326c8
type: Species
is: SBO:0000252
is encoded by: hsa:124454
is: Q5JPH6
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: EARS2
constant: false

metaR DGK2m
product: MODEL1310110025#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110025#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.8 Confidence Level: 2 AUTHORS: NOTES:Added EC- JLR IT
reactant: MODEL1310110025#
is: SBO:0000176
fast: false
name: deoxyguanylate kinase (dGMP:dATP) (mitochondrial)

metaR ARACHCPT2
fast: false
name: carnitine transferase
type: Reaction
reactant: MODEL1310110025#
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110025#
reversible: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_9f5a3a27_16de_48c9_9ead_d9ef008d7f1d
has only substance units: false
boundary condition: true
is: D3DWC4
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:259230
name: SGMS1
initial concentration: NaN
constant: false

metaR r2069
reactant: MODEL1310110025#
modifier: MODEL1310110025#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
kinetic law: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110025#
type: Reaction
is described by: ECO:0000000

metaR r0926
name: Postulated transport reaction
reactant: MODEL1310110025#
reversible: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:
product: MODEL1310110025#
type: Reaction
fast: false
kinetic law: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_b9909b9d_04d8_4cc6_91c4_e7434fc14bab
name: _AU149534_1_e
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:AU149534
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110025#_aa8c28cd_6066_42cb_be7f_02511f6e8bb8
initial amount: NaN
is: SBO:0000252
is: E9PDK1
initial concentration: NaN
type: Species
boundary condition: true
constant: false
name: SLC4A9
has only substance units: false
is encoded by: hsa:83697

metaR HEX10
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (2645.1) or (3099.1) or (3098.3) or (2645.2) or (80201.1) or (3098.2) or (2645.3) or (3098.1) or (3098.4) or (3101.1) or (3098.5) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.1 Confidence Level: 1 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase.
is version of: http://identifiers.org/ec-code/2.7.1.1
modifier: MODEL1310110025#
reactant: MODEL1310110025#
product: MODEL1310110025#
kinetic law: MODEL1310110025#
reversible: false
fast: false
name: hexokinase (D-glucosamine:ATP)
is version of: http://identifiers.org/ec-code/2.7.1.2
is described by: ECO:0000212

metaR CYTK13n
name: cytidylate kinase (dCMP,dATP),nuclear
is: SBO:0000176
modifier: MODEL1310110025#
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
reversible: true

metaR r0139
is version of: http://identifiers.org/ec-code/2.3.2.2
product: MODEL1310110025#
modifier: MODEL1310110025#
is: SBO:0000176
reactant: MODEL1310110025#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
kinetic law: MODEL1310110025#
type: Reaction
is described by: ECO:0000000
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5

http://identifiers.org/biomodels.db/MODEL1310110025#_ddf69a22_3ef4_4b59_a213_72254c199e56
initial concentration: NaN
is encoded by: hsa:6535
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: B4DIA3
name: SLC6A8
type: Species
has only substance units: false

metaM gdp c
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
initial concentration: 1.0
is: HMDB01201
is: SBO:0000247
is: CHEBI:58189
name: GDP
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: C00035
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110025#_0db77a9d_5804_437a_aa64_2ed6592fe793
name: NT5C1B
is: Q96P26
constant: false
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:93034
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaM pchol hs c
is: CHEBI:16110
type: Species
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
name: Phosphatidylcholine
has only substance units: false
initial amount: NaN

metaR ALAR
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000212
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (11212.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 5.1.1.1 Confidence Level: 1 AUTHORS: NOTES:
reversible: true
type: Reaction
product: MODEL1310110025#
fast: false
name: alanine racemase
is: SBO:0000176

metaR r1627
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
fast: false
is: SBO:0000185
reversible: true
type: Reaction
product: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaM i c
is: SBO:0000247
boundary condition: false
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
has only substance units: false
is: CHEBI:16382
initial concentration: 1.0
constant: false
name: iodide
initial amount: NaN
is: HMDB12238
type: Species

metaM 4hphac e
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB00020
is: CHEBI:48999
is: SBO:0000247
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
name: 4-hydroxyphenylacetate
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110025#_98e7b85b_9ac6_4666_af76_28f2b86db8e3
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
name: ADCY4
is: Q8NFM4
boundary condition: true
is encoded by: hsa:196883
is: SBO:0000252
type: Species

metaM c226crn m
is: SBO:0000247
name: cervonyl carnitine
initial concentration: 1.0
is: HMDB06510
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
constant: false
is: http://identifiers.org/pubchem.compound/127055
type: Species

metaR FAOXC10C8x
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->C8)x
type: Reaction

metaR r0321
reversible: false
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/6.3.5.2
modifier: MODEL1310110025#
fast: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
kinetic law: MODEL1310110025#
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
is described by: ECO:0000000
reactant: MODEL1310110025#

metaM 4mop m
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB00695
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
name: 4-methyl-2-oxopentanoate
is: CHEBI:17865

metaM pro L m
is: SBO:0000247
boundary condition: false
is: CHEBI:17203
constant: false
name: L-proline
has only substance units: false
initial concentration: 1.0
is: HMDB00162
initial amount: NaN
type: Species
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145

http://identifiers.org/biomodels.db/MODEL1310110025#_958365f5_e6da_4960_8288_648f7e543b71
constant: false
is: Q8NFW8
initial amount: NaN
boundary condition: true
is encoded by: hsa:55907
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
name: CMAS

http://identifiers.org/biomodels.db/MODEL1310110025#_2f45ee37_5ed0_46a5_9f36_d9012b307e2f
is: SBO:0000252
is: Q9H6Y6
name: MYO5B
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4645
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_d2112d1e_8fca_4245_9999_3fdc5f4c551e
has only substance units: false
is encoded by: hsa:6241
boundary condition: true
is: P31350
is: SBO:0000252
constant: false
initial concentration: NaN
name: RRM2
initial amount: NaN
type: Species

metaR r1628
product: MODEL1310110025#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110025#_af4a5ff5_9c7d_4cde_97d9_efc557603433
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: PANK4
constant: false
type: Species
is encoded by: hsa:55229
is: Q9NVE7
initial amount: NaN
has only substance units: false

metaR r1568
reactant: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000000
kinetic law: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185

metaM crn r
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:16347
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
name: (R)-carnitine
is: HMDB00062
has only substance units: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110025#_20a2823b_02e7_4688_93af_ed2a737a1394
initial concentration: NaN
is: Q86VD9
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
name: PIGZ
type: Species
is encoded by: hsa:80235

metaM oh1 e
notes: FORMULA: HO CHARGE: -1
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
type: Species
name: hydroxide ion
has only substance units: false
is: SBO:0000247
is: HMDB01039
is: C01328

metaM HC01444 e
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
is: SBO:0000247
is: CHEBI:15754
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
name: Galactosylglycerol
type: Species
initial concentration: 1.0

metaR r0779
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: false
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
fast: false
product: MODEL1310110025#
modifier: MODEL1310110025#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR r1618
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
reactant: MODEL1310110025#
modifier: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000000
kinetic law: MODEL1310110025#

metaR DHCR241r
fast: false
type: Reaction
reversible: false
product: MODEL1310110025#
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
is described by: ECO:0000134
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.72
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
name: 24-dehydrocholesterol reductase [Precursor]
reactant: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_bcdb9c04_f27d_4918_9152_fea90d5a7ebf
is encoded by: hsa:9091
initial concentration: NaN
name: PIGQ
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: Q9BRB3
is: SBO:0000252
boundary condition: true

metaR METt4
name: L-methionine transport in via sodium symport
kinetic law: MODEL1310110025#
fast: false
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
product: MODEL1310110025#
reversible: false
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958 NOTES:SAB
reactant: MODEL1310110025#

metaM orn m
is: HMDB00214
boundary condition: false
constant: false
name: Ornithine
notes: FORMULA: C5H13N2O2 CHARGE: 1
initial amount: NaN
is: C01602
initial concentration: 1.0
is: CHEBI:46912
type: Species
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_f20cf38c_e73e_4e69_bf36_897f7db0dfad
initial amount: NaN
type: Species
is encoded by: hsa:1723
is: Q02127
initial concentration: NaN
constant: false
name: DHODH
has only substance units: false
is: SBO:0000252
boundary condition: true

metaM Lcystin e
has only substance units: false
name: L-cystine
initial concentration: 1.0
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
is: CHEBI:16283
is: HMDB00192
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
type: Species

metaR ACNAMPH
reactant: MODEL1310110025#
is: SBO:0000176
product: MODEL1310110025#
reversible: false
fast: false
name: N-Acetylneuraminate 9-phosphate phosphohydrolase
type: Reaction
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 3.1.3.29 Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

metaM 4mzym int2 r
is: HMDB06838
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
name: 4-Methylzymosterol intermediate 2
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C28H44O CHARGE: 0 INCHI: InChI=1/C28H44O/c1-18(2)8-7-9-19(3)22-12-13-24-21-10-11-23-20(4)26(29)15-17-28(23,6)25(21)14-16-27(22,24)5/h8,19-20,22-24H,7,9-17H2,1-6H3/t19-,20?,22?,23?,24?,27-,28+/m1/s1

metaR ADK1
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
name: adenylate kinase
reversible: true
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.3
product: MODEL1310110025#
reactant: MODEL1310110025#

metaR INSTt2r
product: MODEL1310110025#
kinetic law: MODEL1310110025#
fast: false
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110025#
type: Reaction
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
name: inositol transport in via proton symport
is: SBO:0000185

metaR PYRt2r
fast: false
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110025#
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
product: MODEL1310110025#
name: pyruvate reversible transport via proton symport
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110025#

metaM ura c
name: Uracil
is: HMDB00300
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: C00106
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
is: CHEBI:17568
constant: false
boundary condition: false
type: Species

metaR r2120
type: Reaction
reactant: MODEL1310110025#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110025#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110025#
modifier: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_3ac04328_2346_4d40_824d_15b85b1f891d
is encoded by: hsa:AV727634
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
name: _AV727634_1_c
initial amount: NaN
boundary condition: true

metaR EX 4hphac LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Hydroxyphenylacetate exchange
type: Reaction

metaR r1569
reversible: true
is: SBO:0000185
reactant: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110025#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000

metaM 20ahchsterol m
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
name: 20-hydroxycholesterol
is: CHEBI:1296
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500
type: Species
initial amount: NaN
is: HMDB06283

metaR GALtly
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
reactant: MODEL1310110025#
type: Reaction
reversible: false
kinetic law: MODEL1310110025#
product: MODEL1310110025#
fast: false
is described by: ECO:0000000
name: galactose efflux from lysosome

metaM 3snpyr c
is: SBO:0000247
has only substance units: false
name: 3-Sulfinopyruvate
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:1665
type: Species
notes: FORMULA: C3H2O5S CHARGE: -2 INCHI: InChI=1S/C3H4O5S/c4-2(3(5)6)1-9(7)8/h1H2,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C05527
is: HMDB02332

http://identifiers.org/biomodels.db/MODEL1310110025#_206a3a98_7c7c_4263_a9dd_6998fcbab784
initial amount: NaN
initial concentration: NaN
name: SLC7A9
constant: false
is encoded by: hsa:11136
boundary condition: true
has only substance units: false
type: Species
is: P82251
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110025#_1fda4662_cba4_4833_9df0_23c83f9e750d
constant: false
is: E7EML0
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
name: SLC4A8
is encoded by: hsa:9498
has only substance units: false

metaR r1617
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
modifier: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110025#
product: MODEL1310110025#
kinetic law: MODEL1310110025#

metaM 6thf e
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1
constant: false
is: SBO:0000247
type: Species
has only substance units: false
name: hexaglutamyl folate (THF)
is: http://identifiers.org/pubchem.compound/169691
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaR RE0383C
name: RE0383
type: Reaction
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
fast: false
product: MODEL1310110025#
is described by: ECO:0000000
reactant: MODEL1310110025#
reversible: true
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.2
is: SBO:0000176

metaM xol7ah2al c
is: CHEBI:27428
type: Species
initial amount: NaN
constant: false
is: HMDB06894
is: SBO:0000247
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
has only substance units: false
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110025#_36a69978_cc47_4472_989d_cd9efc2e88f3
is encoded by: hsa:206
name: _206_1_c
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110025#_5d8dd62a_29a2_469f_aca3_e474d22cfb32
boundary condition: true
is encoded by: hsa:249
is: B7Z4Y6
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
constant: false
name: ALPL
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_055f55bb_17f5_4d5a_86f9_6b5d901d308f
is: SBO:0000252
boundary condition: true
is: O43426
is encoded by: hsa:8867
has only substance units: false
initial concentration: NaN
type: Species
name: SYNJ1
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_fe4279de_b775_47d1_ac04_43e74513648b
constant: false
is encoded by: hsa:AA629629
initial amount: NaN
initial concentration: NaN
name: _AA629629_1_m
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true

metaR SPMTDe
is: SBO:0000185
product: MODEL1310110025#
kinetic law: MODEL1310110025#
type: Reaction
fast: false
name: SPMTDe
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110025#
is described by: ECO:0000134

metaM dudp m
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: HMDB01000
has only substance units: false
name: dUDP(3-)
is: CHEBI:60471

http://identifiers.org/biomodels.db/MODEL1310110025#_de6656f1_ec1e_40b3_887c_ebc3843ea6a6
is encoded by: hsa:W74642
initial concentration: NaN
initial amount: NaN
constant: false
name: _W74642_1_c
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true

metaR r2121
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
kinetic law: MODEL1310110025#
reversible: true
reactant: MODEL1310110025#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110025#
is: SBO:0000185
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110025#_5bb6ef47_ff36_49bf_aebd_8210c94ef553
initial concentration: NaN
name: MVK
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:4598
is: B2RDU6
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_7b580a4f_dea7_478c_9f69_eaa47456e075
name: ALDH9A1
is encoded by: hsa:223
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: P49189
is: SBO:0000252
type: Species
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110025#_0c6d3034_9710_4112_93c5_16f2057c655d
is encoded by: hsa:3939
boundary condition: true
name: LDHA:LDHB
has part: P00338
initial concentration: NaN
is encoded by: hsa:3945
has only substance units: false
initial amount: NaN
is: SBO:0000297
constant: false
has part: P07195
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_c060b25d_e62d_4248_9486_918d957bcb1b
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:81539
is: Q9H2H9
name: SLC38A1

http://identifiers.org/biomodels.db/MODEL1310110025#_7199410e_dcba_4be6_aa22_d69bd101ba6e
is: Q8IV97
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:8140
name: SLC7A5
constant: false
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN

metaR ADK3
is version of: http://identifiers.org/ec-code/2.7.4.3
kinetic law: MODEL1310110025#
fast: false
product: MODEL1310110025#
is: SBO:0000176
name: adentylate kinase (GTP)
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
type: Reaction
modifier: MODEL1310110025#
reversible: true
reactant: MODEL1310110025#
is described by: ECO:0000269

metaR VALt5m
type: Reaction
is described by: ECO:0000000
name: Valine reversible mitochondrial transport
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
fast: false
product: MODEL1310110025#
reactant: MODEL1310110025#
is: SBO:0000185
reversible: true

metaM ha pre1 e
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:16126
has only substance units: false
name: hyaluronan biosynthesis, precursor 1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_8e2f27bb_3756_42cd_a0f1_028622662c30
initial amount: NaN
name: PLCG1
type: Species
is: SBO:0000252
boundary condition: true
is: P19174
is encoded by: hsa:5335
has only substance units: false
constant: false
initial concentration: NaN

metaR MCITS
reactant: MODEL1310110025#
name: 2-methylcitrate synthase
reversible: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 2.3.3.5 Confidence Level: 2 AUTHORS: PMID:426765,PMID:4507604 NOTES:NCD new EC is 2.3.3.5 - NCD
is described by: ECO:0000000
fast: false
product: MODEL1310110025#
kinetic law: MODEL1310110025#

metaR r2122
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
product: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110025#_a594ded5_e018_415c_9698_c53b7df699d5
name: AMDHD2
is: SBO:0000252
is encoded by: hsa:51005
type: Species
initial amount: NaN
is: Q9Y303
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true

metaM CE4872 m
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:15748
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
constant: false
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
boundary condition: false
is: HMDB00127
initial amount: NaN

metaR r0552
product: MODEL1310110025#
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.3.5.1
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110025#
is: SBO:0000176
type: Reaction
fast: false
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110025#_5ed576b5_ea5b_41a1_85ea_3c10a9ea5822
is encoded by: hsa:219
name: ALDH1B1
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
is: P30837

metaM retinol c
initial amount: NaN
is: HMDB00305
boundary condition: false
type: Species
name: retinol
is: CHEBI:50211
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
is: SBO:0000247

metaM oh1 c
boundary condition: false
constant: false
type: Species
name: hydroxide ion
has only substance units: false
notes: FORMULA: HO CHARGE: -1
initial amount: NaN
is: C01328
is: SBO:0000247
is: HMDB01039
initial concentration: 1.0

metaR r1619
kinetic law: MODEL1310110025#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110025#
fast: false
reversible: true
product: MODEL1310110025#

metaM thyox L e
constant: false
boundary condition: false
is: HMDB00248
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
name: L-thyroxine
initial concentration: 1.0
is: CHEBI:18332

http://identifiers.org/biomodels.db/MODEL1310110025#_34a9ba44_cdcd_4284_ac8a_3e5c24e03216
name: SUCLG2
constant: false
is: Q96I99
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8801
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR GCCcm
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.1.2.10
is described by: ECO:0000269
fast: false
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.8.1.4
modifier: MODEL1310110025#
product: MODEL1310110025#
reversible: true
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.4.2
name: glycine-cleavage complex (lipoylprotein), mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110025#_17e47ffa_80f6_463a_858b_c9e719c8b3e8
has only substance units: false
is: P36269
boundary condition: true
name: GGT5
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:2687

metaR EX but LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Butyrate (n-C4:0) exchange
type: Reaction

metaR SPODMm
type: Reaction
reversible: false
modifier: MODEL1310110025#
fast: false
is version of: http://identifiers.org/ec-code/1.15.1.1
reactant: MODEL1310110025#
is described by: ECO:0000304
product: MODEL1310110025#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6648.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 2 AUTHORS: PMID:12649272,PMID:9376114 NOTES:TV (8-15-2003)
kinetic law: MODEL1310110025#
name: superoxide dismutase

metaR CMPACNAtg
kinetic law: MODEL1310110025#
fast: false
name: CMP-Sia Golgi transport via CMP antiport
product: MODEL1310110025#
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110025#
reactant: MODEL1310110025#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD

metaM Lcystin c
has only substance units: false
boundary condition: false
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
is: HMDB00192
is: CHEBI:16283
name: L-cystine
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species

metaR ALOX5
reactant: MODEL1310110025#
name: Arachidonate 5-lipoxygenase
product: MODEL1310110025#
is described by: ECO:0000269
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:2829172 NOTES:cofactors + usage still not clear see version ALOX5b for ATP concomittant hydrolysis - literature notes in vitro requirement for Ca and ATP for activity in addition to Fe
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.13.11.34
kinetic law: MODEL1310110025#
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110025#_26ad0b8b_f830_4804_a725_c0ee74e45566
name: HK2
initial amount: NaN
is: P52789
constant: false
is encoded by: hsa:3099
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR r2123
type: Reaction
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110025#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110025#_1f198acd_de8c_4f00_9b1a_b5504da749bf
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:54677
is: E7EQF2
boundary condition: true
constant: false
has only substance units: false
type: Species
initial amount: NaN
name: CROT

metaR r0553
fast: false
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
reversible: true
product: MODEL1310110025#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#

metaR CMPSAS
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.43
is: SBO:0000176
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
reactant: MODEL1310110025#
product: MODEL1310110025#
type: Reaction
is described by: ECO:0000304
reversible: false
kinetic law: MODEL1310110025#
name: CMP sialic acid synthase

metaR EX pheme LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for heme
type: Reaction

metaM prostgd2 c
type: Species
boundary condition: false
is: SBO:0000247
name: prostaglandin D2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
initial amount: NaN
is: CHEBI:57406
initial concentration: 1.0
is: HMDB01403
has only substance units: false
constant: false

metaM q10h2 e
initial amount: NaN
is: HMDB13111
boundary condition: false
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
initial concentration: 1.0
name: Ubiquinol-10
type: Species
is: http://identifiers.org/pubchem.compound/6504740
has only substance units: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110025#_60d6a8f5_8a0b_4f4b_8493_990a785dcb54
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:11112
constant: false
is: P31937
name: HIBADH
type: Species
has only substance units: false

metaM fe2 c
constant: false
has only substance units: false
is: CHEBI:29033
is: SBO:0000247
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
is: HMDB00692
boundary condition: false
name: Fe2+
initial concentration: 1.0
initial amount: NaN
is: C00023
type: Species

metaM chol n
is: SBO:0000247
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
name: choline
has only substance units: false
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: HMDB00097
is: CHEBI:15354
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_0a3c2073_867a_4ecc_94c1_f5a494701a40
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

metaR r1564
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110025#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110025#

metaR L LACt2r
reactant: MODEL1310110025#
reversible: true
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
is: SBO:0000185
type: Reaction
product: MODEL1310110025#
is described by: ECO:0000269
name: L-lactate reversible transport via proton symport
fast: false
modifier: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_9ff143a4_8fb0_467a_9330_2dc4d4945ed1
boundary condition: true
is: P20020
name: ATP2B1
is encoded by: hsa:490
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false

metaR LTC4CP
reversible: true
reactant: MODEL1310110025#
is described by: ECO:0000000
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
is: SBO:0000176
name: Leukotriene C4 carboxypeptidase
fast: false
product: MODEL1310110025#
type: Reaction

metaM CE5121 m
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
name: trans-3-decenoyl-CoA
boundary condition: false
is: CHEBI:57449
initial concentration: 1.0
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
has only substance units: false

metaM q10 c
is: HMDB01072
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:46245
constant: false
type: Species
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
initial concentration: 1.0
is: SBO:0000247
name: ubiquinone-10

http://identifiers.org/biomodels.db/MODEL1310110025#_a7946626_aef8_48d4_a9eb_fa5bb0f3480f
initial amount: NaN
is: P11310
name: ACADM
has only substance units: false
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:34

metaR MTHGXLt
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110025#
reversible: false
type: Reaction
product: MODEL1310110025#
is: SBO:0000185
reactant: MODEL1310110025#
name: Methylglyoxal transport (cytosol to extracellular)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:MM

metaM chol m
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: CHEBI:15354
initial concentration: 1.0
is: HMDB00097
constant: false
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
name: choline

http://identifiers.org/biomodels.db/MODEL1310110025#_4c2b1e9a_6dd6_4f04_a4b9_3c655f6eaf5a
type: Species
initial amount: NaN
is encoded by: hsa:6550
is: P48764
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
name: SLC9A3
initial concentration: NaN

metaM crn m
is: CHEBI:16347
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB00062
is: C00318
is: SBO:0000247
type: Species
name: L-Carnitine
boundary condition: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318

metaM CE5788 e
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
constant: false
is: HMDB02710
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:27485
name: kinetensin 1-7
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_491a4ed7_559c_472b_b68b_1d8d515d8d26
is: SBO:0000252
is: Q9UI40
is encoded by: hsa:25769
constant: false
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
name: SLC24A2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_792409f4_4dd5_4c1e_b79f_14dacc6e9dc6
has only substance units: false
boundary condition: true
is encoded by: hsa:23007
type: Species
is: SBO:0000252
initial amount: NaN
is: Q4KWH8
name: PLCH1
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_e45463d2_50d5_4254_9ea9_2b33273bc98e
is: Q99714
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3028
has only substance units: false
boundary condition: true
name: HSD17B10
constant: false
initial amount: NaN
type: Species

metaR r0774
reactant: MODEL1310110025#
is described by: ECO:0000000
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
type: Reaction
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false

http://identifiers.org/biomodels.db/MODEL1310110025#_ad46b2e8_7b82_4dec_bb86_48c96e829376
name: GGT1
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: P19440
initial concentration: NaN
is encoded by: hsa:2678
boundary condition: true
is: SBO:0000252

metaM acald e
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
constant: false
is: CHEBI:15343
is: SBO:0000247
type: Species
is: HMDB00990
boundary condition: false
has only substance units: false
name: acetaldehyde

metaR r1565
is described by: ECO:0000000
reactant: MODEL1310110025#
fast: false
kinetic law: MODEL1310110025#
is: SBO:0000185
product: MODEL1310110025#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR CYTK5n
reactant: MODEL1310110025#
modifier: MODEL1310110025#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
reversible: true
kinetic law: MODEL1310110025#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110025#
name: cytidylate kinase (CMP),nuclear

http://identifiers.org/biomodels.db/MODEL1310110025#_0320223a_1ca5_4746_adee_1c0235977ce4
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:AW299740
initial concentration: NaN
type: Species
name: _AW299740_1_m
initial amount: NaN

metaM succoa m
is: CHEBI:57292
is: HMDB01022
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
name: Succinyl-CoA
has only substance units: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
boundary condition: false
is: SBO:0000247

metaM imp c
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
initial amount: NaN
type: Species
constant: false
is: CHEBI:58053
has only substance units: false
is: SBO:0000247
name: IMP
is: C00130
is: HMDB00175
initial concentration: 1.0
boundary condition: false

metaM utp e
name: UTP(4-)
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
has only substance units: false
is: HMDB00285
is: CHEBI:46398

metaR ATPtx
product: MODEL1310110025#
type: Reaction
reactant: MODEL1310110025#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
reversible: true
fast: false
is: SBO:0000185
name: ATP transporter, peroxisomal
kinetic law: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_4ee09a63_46df_4c46_84ed_48afb0bab8cb
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
name: PYCR2
has only substance units: false
is encoded by: hsa:29920
constant: false
is: Q96C36
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_0b81ebde_37a7_4e0a_a914_4b5bfc07460f
is: SBO:0000252
is: P42765
is encoded by: hsa:10449
boundary condition: true
constant: false
name: ACAA2
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN

metaR XOL27OHtm
reactant: MODEL1310110025#
product: MODEL1310110025#
type: Reaction
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: 27 hydroxy cholesterol transport
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110025#_c5f79450_f581_4d67_a382_f7b808990a3a
initial amount: NaN
name: PANK4
has only substance units: false
constant: false
type: Species
is: Q9NVE7
is encoded by: hsa:55229
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaM ura e
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
is: HMDB00300
initial concentration: 1.0
name: uracil
boundary condition: false
is: CHEBI:17568
type: Species

metaR r1566
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110025#
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110025#_76761e5d_def3_462a_bf2d_3df05b90e41f
name: PIGA
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is: B3KUV7
is encoded by: hsa:5277
initial amount: NaN
is: SBO:0000252

metaR THCHOLSTOICtm
fast: false
reactant: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
name: lipid, flip-flop intracellular transport
kinetic law: MODEL1310110025#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
type: Reaction

metaM 3hpp m
is: SBO:0000247
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
initial concentration: 1.0
boundary condition: false
name: 3-hydroxypropionate
has only substance units: false
is: CHEBI:16510
initial amount: NaN
type: Species
constant: false
is: HMDB00700

metaR r0130
is: SBO:0000176
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
kinetic law: MODEL1310110025#
is described by: ECO:0000000
reactant: MODEL1310110025#
type: Reaction
fast: false
product: MODEL1310110025#
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110025#_6536bb35_60f6_4654_a9ba_f5e0c581d9e3
name: PANK2
is: SBO:0000252
is: Q6P1K9
type: Species
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:80025
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_5f6537d1_ea6e_4d98_8fee_0610220e7681
initial concentration: NaN
is encoded by: hsa:4718
has only substance units: false
constant: false
type: Species
is: Q549M5
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: NDUFC2

metaM acald c
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
type: Species
is: CHEBI:15343
has only substance units: false
boundary condition: false
name: acetaldehyde
initial concentration: 1.0
is: HMDB00990

http://identifiers.org/biomodels.db/MODEL1310110025#_b8b3bae3_48a7_4159_a320_b535eac61dd3
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:3938
is: P09848
name: LCT
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110025#_a7cd4d24_c69a_4087_ab9b_09583bed4e3d
name: ACSS2
constant: false
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:55902
is: Q5QPH3
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaM phe L e
has only substance units: false
name: L-phenylalanine
initial amount: NaN
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:17295
is: HMDB00159
constant: false
type: Species

metaR r1567
reactant: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
product: MODEL1310110025#
kinetic law: MODEL1310110025#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110025#_2b9896ff_7824_4e52_a486_8a650e8525b6
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: Q9H008
name: LHPP
is encoded by: hsa:64077
boundary condition: true
constant: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_a2714aea_2ec8_4c23_9a99_b3ade142036c
is: Q53Y41
is encoded by: hsa:1644
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
name: DDC
constant: false

metaM itacon m
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB02092
has only substance units: false
is: CHEBI:17240
initial amount: NaN
name: itaconate(2-)
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_5c894db2_c746_4640_95e5_9b9858950c43
type: Species
boundary condition: true
constant: false
has only substance units: false
is: P35557
is: SBO:0000252
is encoded by: hsa:2645
initial concentration: NaN
name: GCK
initial amount: NaN

metaR EX 3mop LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxopentanoate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_589de025_6b32_46a3_9970_5e446d6f5553
is encoded by: hsa:54407
constant: false
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: SLC38A2
is: SBO:0000252
is: Q96QD8

metaR CHATn
name: Choline O-acetyltransferase
is version of: http://identifiers.org/ec-code/2.3.1.6
is: SBO:0000176
modifier: MODEL1310110025#
reversible: true
type: Reaction
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110025#_cae689f7_3bd3_4647_8e6d_08e18c927177
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:23475
type: Species
has only substance units: false
name: QPRT
constant: false
boundary condition: true
initial amount: NaN
is: Q15274

metaM o2s c
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: SBO:0000247
is: CHEBI:18421
constant: false
name: superoxide
type: Species
has only substance units: false
is: HMDB02168

http://identifiers.org/biomodels.db/MODEL1310110025#_14639f2f_c880_4811_98ed_c85ad634858e
is encoded by: hsa:3612
boundary condition: true
has only substance units: false
is: B7Z6Q4
constant: false
initial amount: NaN
is: SBO:0000252
name: IMPA1
initial concentration: NaN
type: Species

metaR r2128
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110025#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
modifier: MODEL1310110025#
reactant: MODEL1310110025#
reversible: true
type: Reaction
is: SBO:0000185
product: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_e7688573_4a46_4296_929b_727d5e98e0ab
initial amount: NaN
is encoded by: hsa:6307
name: MSMO1
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
is: A8MYF6
type: Species
initial concentration: NaN

metaR r0494
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000176
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#

metaM ddcacoa x
is: HMDB03571
constant: false
has only substance units: false
initial amount: NaN
is: C01832
is: CHEBI:57375
is: SBO:0000247
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
type: Species
initial concentration: 1.0
name: Dodecanoyl-CoA (n-C12:0CoA)
boundary condition: false

metaM hom L e
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB00719
name: L-homoserine
initial amount: NaN
is: CHEBI:15699
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
boundary condition: false

metaR r0614
reversible: true
type: Reaction
reactant: MODEL1310110025#
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
kinetic law: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000000
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:

metaR PACCOAL
type: Reaction
reversible: false
name: phenylacetate-CoA ligase
kinetic law: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 6.2.1.30 Confidence Level: 2 AUTHORS: NOTES:JLR
reactant: MODEL1310110025#
is: SBO:0000176
fast: false

metaM orn e
is: CHEBI:0
initial concentration: 1.0
type: Species
name: Ornithine
notes: FORMULA: C5H13N2O2 CHARGE: 1
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB00214
is: C01602
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_f622ac10_129d_45c4_b77a_b5d4ccdaf0e0
initial amount: NaN
name: IDH2
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
is: P48735
has only substance units: false
is encoded by: hsa:3418

http://identifiers.org/biomodels.db/MODEL1310110025#_f13fad36_a25a_42f4_9e25_7d8cbb79f705
is: Q9BWD1
has only substance units: false
name: ACAT2
initial amount: NaN
constant: false
is encoded by: hsa:39
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR EX chol LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Choline
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_e863adbc_c06b_44aa_9a1e_eb2d9d895301
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110025#_ca772d66_3f10_4435_9efd_1f0058f2d4f0
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
is: Q53Y25
is encoded by: hsa:2645
name: GCK
type: Species
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_b9cbbc0c_06a8_486e_84a0_58692d087387
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:5332
constant: false
is: SBO:0000252
name: PLCB4
is: E2QRH8

metaR EX drib LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Deoxyribose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_61edefef_016b_48bf_abef_1a49958912a6
is encoded by: hsa:4716
has only substance units: false
name: NDUFB10
is: SBO:0000252
initial amount: NaN
constant: false
is: A8K761
initial concentration: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_0067e5a6_eb8d_45f1_ad92_5ea26fe04434
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:2686
boundary condition: true
initial concentration: NaN
is: A0PJJ9
name: GGT7

http://identifiers.org/biomodels.db/MODEL1310110025#_c3d89fc5_62c5_4e20_a805_c4b657cb1bcc
is encoded by: hsa:377841
is: Q5MY95
boundary condition: true
initial amount: NaN
type: Species
constant: false
name: ENTPD8
has only substance units: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110025#_c1e45fc7_a22a_44d6_bb09_8f6010e03189
name: _100287639_1_c
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:100287639
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_edd7a164_2324_4bdf_8b84_c378b3097964
is encoded by: hsa:27068
boundary condition: true
initial concentration: NaN
name: PPA2
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false

metaR CHLtm
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110025#
name: choline transport via diffusion (cytosol to mitochondria)
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10984 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110025#_da5fda73_c84e_4b2a_8d97_e124f4364cc8
has only substance units: false
is encoded by: hsa:7378
name: UPP1
initial amount: NaN
boundary condition: true
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252

metaR MAN1PT2
fast: false
is: SBO:0000176
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (29926.2) or (29926.1) or (29925.2) or (29925.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.22 Confidence Level: 0 AUTHORS: NOTES:JLR
is version of: http://identifiers.org/ec-code/2.7.7.13
product: MODEL1310110025#
name: mannose-1-phosphate guanylyltransferase (GDP)
type: Reaction
reversible: false
modifier: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_7fdab89e_3d74_4dd6_9f4d_644a8d9c98bc
is: SBO:0000252
name: CA3
boundary condition: true
is: P07451
type: Species
is encoded by: hsa:761
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false

metaM HC01609 e
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
is: CHEBI:28766
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: UroporphyrinogenI
initial amount: NaN
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_970fd5d9_5f11_44bf_a778_2f384e7f2719
name: ADH6
has only substance units: false
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
is: P28332
initial concentration: NaN
is encoded by: hsa:130
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110025#_d796ca57_bce9_4882_8ab0_de59a03e3313
constant: false
is: Q16836
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3033
name: HADH
has only substance units: false
boundary condition: true
type: Species

metaR r2129
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110025#
is: SBO:0000185
reversible: true
reactant: MODEL1310110025#
is described by: ECO:0000000
modifier: MODEL1310110025#
type: Reaction
fast: false
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM fprica c
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:58467
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB01439
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
notes: FORMULA: C10H13N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01344 EHMN_ABBREVIATION: C04734
is: C04734
initial amount: NaN

metaR FUMTSULtm
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
fast: false
reversible: true
type: Reaction
modifier: MODEL1310110025#
is: SBO:0000185
name: Fumarate:thiosulfate antiport, mitochondrial
reactant: MODEL1310110025#
is described by: ECO:0000269
product: MODEL1310110025#

metaM ach n
is: HMDB00895
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
has only substance units: false
type: Species
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: acetylcholine
is: CHEBI:15355

http://identifiers.org/biomodels.db/MODEL1310110025#_0b7ebdf6_fb61_4f6c_99fc_f01ec9a6464e
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is: G3XAJ0
initial concentration: NaN
name: ACAD10
is: SBO:0000252
type: Species
is encoded by: hsa:80724

metaR r0470
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
is: SBO:0000176
product: MODEL1310110025#
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110025#_505c6e94_54a5_4aec_be99_fa0d17394802
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110025#_8654903c_6e16_48ce_b912_22588ff68c91
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:54963
is: Q53HM1
name: UCKL1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_869e5384_d1a3_4bf1_9ac6_258eabf4f726
is encoded by: hsa:U37519
type: Species
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
name: _U37519_1_m
initial concentration: NaN
initial amount: NaN

metaM hom L c
boundary condition: false
has only substance units: false
name: L-homoserine
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
is: CHEBI:15699
initial amount: NaN
constant: false
type: Species
is: HMDB00719
is: SBO:0000247
initial concentration: 1.0

metaM gthox m
initial concentration: 1.0
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
type: Species
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB03337
initial amount: NaN
is: CHEBI:58297
boundary condition: false

metaR TREHe
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/3.2.1.28
is: SBO:0000176
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110025#
fast: false
name: alpha,alpha-trehalase
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR
type: Reaction

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

metaR r0616
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
type: Reaction
reactant: MODEL1310110025#
fast: false
product: MODEL1310110025#
is described by: ECO:0000000
modifier: MODEL1310110025#
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
is: SBO:0000176
kinetic law: MODEL1310110025#
reversible: true

metaR NORANMT
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (5409.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.1.1.28 Confidence Level: 4 AUTHORS: NOTES:SAB
reversible: false
is described by: ECO:0000269
fast: false
name: noradrenaline N-methyltransferase
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.1.1.28
is: SBO:0000176
type: Reaction
product: MODEL1310110025#

metaM CE0785 m
name: cis,cis-myristo-5,8-dienoyl-CoA
constant: false
is: C01936
initial amount: NaN
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5041
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaM fe2 e
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
initial amount: NaN
is: C00023
is: CHEBI:29033
is: SBO:0000247
type: Species
constant: false
boundary condition: false
is: HMDB00692
name: Fe2+
has only substance units: false
initial concentration: 1.0

metaR LEUKTRD4t
reversible: true
name: leukotriene D4 transport
kinetic law: MODEL1310110025#
fast: false
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
product: MODEL1310110025#
is described by: ECO:0000269
type: Reaction
is: SBO:0000185

metaM q10h2 c
boundary condition: false
type: Species
constant: false
is: http://identifiers.org/pubchem.compound/6504740
has only substance units: false
name: Ubiquinol-10
initial amount: NaN
is: HMDB13111
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
initial concentration: 1.0
is: SBO:0000247

metaR RE1530C
is: SBO:0000176
name: RE1530
reversible: true
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
fast: false
product: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_45f26ae1_e3d7_4699_b792_286ea4774f65
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:8760
has only substance units: false
boundary condition: true
name: CDS2
constant: false
is: O95674
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110025#_09aaa4d6_4545_4d8a_9b43_150af079ffbd
boundary condition: true
is: SBO:0000252
is: P04183
initial amount: NaN
name: TK1
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:7083
constant: false

metaR DRIBt
is: SBO:0000185
fast: false
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
type: Reaction
reversible: true
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
is described by: ECO:0000000
name: deoxyribose transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110025#_2801067e_4849_41f8_9438_3765dab67a94
name: NDUFB6
is: O95139
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4712
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false

metaR MTHFDm
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
is version of: http://identifiers.org/ec-code/6.3.4.3
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.9
type: Reaction
modifier: MODEL1310110025#
reversible: true
is described by: ECO:0000269
product: MODEL1310110025#
is: SBO:0000176

metaM ahcys m
name: S-Adenosyl-L-homocysteine
is: HMDB00939
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
has only substance units: false
is: C00021
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16680
constant: false
boundary condition: false
type: Species
initial amount: NaN

metaM HC02179 e
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
initial concentration: 1.0
is: CHEBI:34306
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: 20-hydroxy-arachidonate
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_15b929a0_13f5_4fec_a013_ed16dc73c5f5
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110025#_1d3ec050_b767_4105_8308_6d61bd5ff6d5
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
boundary condition: true
name: CYP1B1
is encoded by: hsa:1545
is: Q16678
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_ffe9945a_bafb_4cc5_9e97_2458e53c6d37
is: SBO:0000252
name: SLC5A10
has only substance units: false
constant: false
is encoded by: hsa:125206
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is: A0PJK1

metaR PYNP2r
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2
modifier: MODEL1310110025#
type: Reaction
fast: false
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.4.2.3
is described by: ECO:0000269
product: MODEL1310110025#
name: pyrimidine-nucleoside phosphorylase (uracil)
is: SBO:0000176
reversible: true

metaR CHOLATEt
modifier: MODEL1310110025#
is: SBO:0000185
name: cholate transport via bicarbonate countertransport
is described by: ECO:0000269
type: Reaction
fast: false
kinetic law: MODEL1310110025#
reversible: true
reactant: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ

metaR GLYC3Ptmc
reversible: true
fast: false
kinetic law: MODEL1310110025#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: added during gap filling. No evidence found for such a reaction. NOTES:added during gap filling. No evidence found for such a reaction.
reactant: MODEL1310110025#
type: Reaction
name: glycerol-3-phopshate transport, cytoplasm
is described by: ECO:0000134
product: MODEL1310110025#

metaM q10 e
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
name: ubiquinone-10
type: Species
constant: false
is: CHEBI:46245
initial amount: NaN
boundary condition: false
is: HMDB01072
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaM mthgxl e
has only substance units: false
is: HMDB01167
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
name: methylglyoxal
type: Species
is: CHEBI:17158

http://identifiers.org/biomodels.db/MODEL1310110025#_33f18785_3d75_40e0_8d95_74e31fa3f289
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:9563
is: O95479
constant: false
initial amount: NaN
name: H6PD
is: SBO:0000252
has only substance units: false

metaR FERO
modifier: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: (9843.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
kinetic law: MODEL1310110025#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000134
reversible: false
name: ferroxidase

metaR r1116
reversible: true
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:
product: MODEL1310110025#
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
fast: false

metaM dolp U c
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:57683
has only substance units: false
name: dolichyl phosphate(2-)

http://identifiers.org/biomodels.db/MODEL1310110025#_e7c3d2dc_2424_47e8_9897_fd4b3968b2bd
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:HG2846-HT2983
has only substance units: false
name: _HG2846_HT2983_1_c
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_e4541e5f_fdd5_4535_995b_a2655d3a103e
is: P14618
is: SBO:0000252
boundary condition: true
name: PKM2
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5315
type: Species

metaR KCC2t
modifier: MODEL1310110025#
reversible: true
type: Reaction
name: K+-Cl- cotransporter (NH4+)
is described by: ECO:0000269
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
product: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
is: SBO:0000185

metaR r2124
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reversible: true
fast: false
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110025#
modifier: MODEL1310110025#
type: Reaction

metaR r0472
is described by: ECO:0000000
product: MODEL1310110025#
type: Reaction
fast: false
reversible: true
is: SBO:0000176
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1

http://identifiers.org/biomodels.db/MODEL1310110025#_d2b3a630_e1dd_4335_96b1_57914158a6c1
name: ALDH4A1
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:8659
type: Species

metaM thymd c
initial concentration: 1.0
boundary condition: false
name: Thymidine
constant: false
type: Species
is: C00214
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
is: SBO:0000247
has only substance units: false
is: HMDB00273
is: CHEBI:17748
initial amount: NaN

metaR BTNt2
name: Biotin reversible transport via proton symport
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD
product: MODEL1310110025#
reversible: true
kinetic law: MODEL1310110025#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110025#
modifier: MODEL1310110025#
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110025#_03f62f35_ddea_4b0a_bcef_eede14528c0a
type: Species
is: P13929
name: ENO3
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2027
initial amount: NaN
initial concentration: NaN

metaR PHEMEt
is described by: ECO:0000269
kinetic law: MODEL1310110025#
type: Reaction
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (113235.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:16143108 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110025#
reversible: false
name: heme transport
modifier: MODEL1310110025#
fast: false

metaR r1459
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110025#
product: MODEL1310110025#
name: Transport reaction
kinetic law: MODEL1310110025#
type: Reaction
is: SBO:0000185
fast: false

metaR r0558
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000176
product: MODEL1310110025#
reactant: MODEL1310110025#
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.3
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
kinetic law: MODEL1310110025#
reversible: true

metaR r0618
type: Reaction
fast: false
reactant: MODEL1310110025#
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
product: MODEL1310110025#
is described by: ECO:0000000
kinetic law: MODEL1310110025#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:

metaR ADK3m
name: adentylate kinase (GTP)
reversible: true
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.10
product: MODEL1310110025#
type: Reaction
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
is: SBO:0000176
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
reactant: MODEL1310110025#

metaR NCNt
is: SBO:0000185
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
fast: false
reactant: MODEL1310110025#
name: Na+/Ca2+-NH4+ exchange
is described by: ECO:0000269
product: MODEL1310110025#
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
type: Reaction
reversible: true

metaR r0497
product: MODEL1310110025#
reversible: true
reactant: MODEL1310110025#
modifier: MODEL1310110025#
fast: false
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
type: Reaction
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.4.2
kinetic law: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_92757a99_1fd9_479f_b80d_4c131ce32e22
is: O43181
initial amount: NaN
type: Species
has only substance units: false
name: NDUFS4
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4724

http://identifiers.org/biomodels.db/MODEL1310110025#_5a91edab_9758_4dbb_9d6b_5f0d48abe867
type: Species
is encoded by: hsa:10007
name: GNPDA1
boundary condition: true
is: P46926
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false

metaM acald m
is: CHEBI:15343
is: HMDB00990
boundary condition: false
type: Species
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
is: SBO:0000247
has only substance units: false
name: acetaldehyde
initial amount: NaN
initial concentration: 1.0
constant: false

metaR r2125
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
is: SBO:0000185

metaR RE1517M
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
product: MODEL1310110025#
modifier: MODEL1310110025#
reversible: true
is version of: http://identifiers.org/ec-code/1.3.99.13
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
reactant: MODEL1310110025#
name: RE1517
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110025#_c2d92f3f_bf55_46e9_a4a4_3a00536a3804
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
name: LDHC
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3948
constant: false

metaR r0559
is: SBO:0000176
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.5.1.3
fast: false
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
reversible: true
product: MODEL1310110025#
reactant: MODEL1310110025#
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110025#_88995167_9a0e_4c8c_b655_16669afb1bab
constant: false
name: SLC38A3
initial concentration: NaN
is: Q99624
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10991

http://identifiers.org/biomodels.db/MODEL1310110025#_4171fc40_c6b4_4c4b_8b2d_1fd6b259ba04
is encoded by: hsa:54675
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: Q9UJA2
type: Species
name: CRLS1
boundary condition: true
constant: false

metaR HDCAtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
fast: false
product: MODEL1310110025#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110025#
reversible: true
kinetic law: MODEL1310110025#

metaR PYRt2m
reversible: true
kinetic law: MODEL1310110025#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110025#
type: Reaction
is: SBO:0000185
name: pyruvate mitochondrial transport via proton symport
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD
product: MODEL1310110025#
reactant: MODEL1310110025#

metaR RE3627M
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110025#
type: Reaction
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
name: RE3627
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
modifier: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_92b06c5c_aec4_4e32_ac15_ac494103a1b5
is: P17516
type: Species
name: AKR1C4
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:1109
initial amount: NaN

metaM kynate c
boundary condition: false
name: kynurenate
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB00715
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
is: CHEBI:58454

http://identifiers.org/biomodels.db/MODEL1310110025#_1f55cca9_3266_4748_8667_367a67c872c3
has only substance units: false
is: O95992
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:9023
boundary condition: true
name: CH25H

http://identifiers.org/biomodels.db/MODEL1310110025#_fad0c6cc_e0c2_4e98_a7fa_ec7040b5d849
name: AK1
has only substance units: false
is: SBO:0000252
is: P00568
type: Species
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:203

metaR r2126
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110025#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110025#
modifier: MODEL1310110025#
reactant: MODEL1310110025#
reversible: true
type: Reaction

metaR r0474
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
type: Reaction
fast: false
product: MODEL1310110025#
is: SBO:0000176
reactant: MODEL1310110025#
reversible: true
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
is described by: ECO:0000000

metaR r0829
product: MODEL1310110025#
reversible: true
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
type: Reaction
fast: false
is: SBO:0000185
is version of: http://identifiers.org/ec-code/4.1.1.37
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110025#

metaM crn x
is: CHEBI:16347
is: SBO:0000247
name: L-Carnitine
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
boundary condition: false
is: C00318
constant: false
has only substance units: false
is: HMDB00062
type: Species

metaM orn c
constant: false
notes: FORMULA: C5H13N2O2 CHARGE: 1
initial amount: NaN
is: SBO:0000247
is: HMDB00214
is: CHEBI:0
is: C01602
has only substance units: false
name: Ornithine
initial concentration: 1.0
boundary condition: false
type: Species

metaR P5CDm
fast: false
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.5.1.12
product: MODEL1310110025#
is: SBO:0000176
kinetic law: MODEL1310110025#
name: 1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
reactant: MODEL1310110025#
modifier: MODEL1310110025#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Glutamate metabolism EC Number: 1.5.1.12 Confidence Level: 4 AUTHORS: PMID:8621661,PMID:9700195 NOTES:NCD

metaM dmnoncrn c
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
name: 4,8-dimethylnonanoyl carnitine
type: Species
is: SBO:0000247
notes: FORMULA: C18H37NO4 CHARGE: 0
boundary condition: false
is: HMDB06202

metaR r0556
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
fast: false
is version of: http://identifiers.org/ec-code/1.14.19.1
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
is: SBO:0000176
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
reversible: true

metaR ARACHDt2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
reactant: MODEL1310110025#
is: SBO:0000185
name: fatty acid transport via diffusion
kinetic law: MODEL1310110025#
product: MODEL1310110025#
fast: false
is described by: ECO:0000000
type: Reaction

metaR r2127
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
reversible: true
fast: false
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110025#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction

metaM utp n
is: HMDB00285
is: SBO:0000247
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
is: CHEBI:46398
name: UTP(4-)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_6cc170d4_2f3e_4192_bb86_4b415f34d63b
is encoded by: hsa:219
type: Species
constant: false
name: ALDH1B1
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: P30837
has only substance units: false
initial concentration: NaN

metaR APOCF
is: SBO:0000176
type: Reaction
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10191093 NOTES:IT faked reaction to balance reaction in human biotin metabolism
is described by: ECO:0000000
kinetic law: MODEL1310110025#
fast: false
reversible: false
name: Apocarboxylase formation
product: MODEL1310110025#

metaR EX nac LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinate exchange
type: Reaction

metaM dutp c
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
initial concentration: 1.0
initial amount: NaN
name: dUTP
boundary condition: false
is: C00460
is: SBO:0000247
type: Species
is: HMDB01191
has only substance units: false
constant: false
is: CHEBI:17625

http://identifiers.org/biomodels.db/MODEL1310110025#_1247452b_ce11_41b2_a3e0_b9667ce70414
is: Q9H310
constant: false
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:57127
initial concentration: NaN
name: RHBG

http://identifiers.org/biomodels.db/MODEL1310110025#_dc968792_f5b1_4b27_88bb_00ac48b4290d
initial concentration: NaN
is encoded by: hsa:3423
has only substance units: false
type: Species
is: B4DGD7
initial amount: NaN
name: IDS
is: SBO:0000252
boundary condition: true
constant: false

metaR r0523
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.17.4.1
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
is described by: ECO:0000000
product: MODEL1310110025#
modifier: MODEL1310110025#
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
fast: false
reversible: false
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_a7f178f4_2f70_4efc_b59d_5d84874c015d
name: CA12
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:771
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_ca3862fb_7b95_444f_beb8_f68222357a81
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:80864
name: EGFL8
is: Q99944

metaM cspg b l
type: Species
is: SBO:0000247
is: HMDB06202
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
initial concentration: 1.0

metaM trdox m
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
name: Oxidized thioredoxin
constant: false
has only substance units: false
is: CHEBI:18191
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110025#_7887b0f1_b286_4b99_81c2_e92a0ea57a63
name: _AA854479_1_m
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AA854479
boundary condition: true
has only substance units: false

metaM prostgh2 c
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
constant: false
is: HMDB01381
type: Species
is: SBO:0000247
name: prostaglandin H2(1-)
initial amount: NaN
is: CHEBI:57405
has only substance units: false

metaR 3SALATAi
is version of: http://identifiers.org/ec-code/2.6.1.1
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
fast: false
product: MODEL1310110025#
is described by: ECO:0000304
is: SBO:0000176
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM. activity measured in rat, 3-sulfinoalanine is substrate found in human brain
reversible: false
name: 3-sulfino-alanine transaminase (irreversible)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_0568d4b2_e5ba_41ed_8629_4b2df173e58a
name: SLC2A6
has only substance units: false
is encoded by: hsa:11182
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is: Q9UGQ3
boundary condition: true

metaM ser L c
boundary condition: false
constant: false
is: CHEBI:17115
has only substance units: false
is: HMDB00187
initial amount: NaN
name: L-serine
is: SBO:0000247
type: Species
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
initial concentration: 1.0

metaR r2372
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110025#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110025#
is: SBO:0000185
reversible: true
reactant: MODEL1310110025#
type: Reaction

metaM leu L c
initial amount: NaN
is: CHEBI:15603
initial concentration: 1.0
boundary condition: false
is: HMDB00687
name: L-leucine
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: SBO:0000247
has only substance units: false
constant: false
type: Species

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaR r0360
modifier: MODEL1310110025#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/6.2.1.16
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
reactant: MODEL1310110025#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
fast: false
product: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_ae2950ff_e10c_4f3c_8b75_bae855b9ace1
is encoded by: hsa:349565
boundary condition: true
has only substance units: false
is: Q96T66
is: SBO:0000252
name: NMNAT3
initial amount: NaN
constant: false
type: Species
initial concentration: NaN

metaM CE2418 m
boundary condition: false
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
is: CHEBI:28387
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB11123
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418

http://identifiers.org/biomodels.db/MODEL1310110025#_6fbe1e3f_5f0e_4ba8_abec_9bbc744c803a
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: O43772
boundary condition: true
is encoded by: hsa:788
name: SLC25A20
initial concentration: NaN
is: SBO:0000252

metaR GLCt1r
kinetic law: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (66035.1) or (6517.1) or (56606.1) or (154091.1) or (6513.1) or (11182.1) or (29988.1) or (6514.1) or (155184.1) or (56606.2) or (144195.1) or (6515.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860667,PMID:10860996,PMID:10970791,PMID:11247674,PMID:11583593,PMID:11592815,PMID:11780753,PMID:11832379,PMID:11882499,PMID:12135767,PMID:12483288,PMID:12504846,PMID:12750891,PMID:12914765,PMID:14739288,PMID:15033637,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:
reversible: true
is: SBO:0000185
reactant: MODEL1310110025#
name: glucose transport (uniport)
type: Reaction
fast: false
is described by: ECO:0000269
modifier: MODEL1310110025#

metaR UMPKn
kinetic law: MODEL1310110025#
type: Reaction
fast: false
is: SBO:0000176
name: UMP kinase, nuclear
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110025#_d0571e02_b08d_4c58_8f7e_f4f7d083fd45
name: GPD1
initial concentration: NaN
is encoded by: hsa:2819
is: SBO:0000252
boundary condition: true
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: F8W1L5

metaM acrn x
name: O-acetylcarnitine
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
type: Species
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
initial amount: NaN
is: SBO:0000247
is: HMDB00201
is: CHEBI:57589

metaR PEt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:
reversible: true
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
name: phosphatidylethanolamine transport
is: SBO:0000185
type: Reaction
product: MODEL1310110025#
is described by: ECO:0000000
fast: false

metaM fol c
type: Species
notes: FORMULA: C19H18N7O6 CHARGE: -1
initial amount: NaN
is: HMDB00121
is: SBO:0000247
has only substance units: false
name: Folate
initial concentration: 1.0
boundary condition: false
constant: false

metaR ACCOAtn
is: SBO:0000185
kinetic law: MODEL1310110025#
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
name: acetyl-CoA transport, nuclear

http://identifiers.org/biomodels.db/MODEL1310110025#_8dc0c1b9_587a_49f0_b745_81b6dfd035f5
initial amount: NaN
name: DEGS1
constant: false
has only substance units: false
is: O15121
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8560
boundary condition: true
type: Species

metaM chsterol r
boundary condition: false
has only substance units: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
initial concentration: 1.0
is: SBO:0000247
is: HMDB00067
type: Species
name: cholesterol
initial amount: NaN
constant: false
is: CHEBI:16113

metaR PI4PLC
name: phosphatidylinositol 4-phosphate phospholipase C
type: Reaction
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/3.1.4.11
fast: false
is described by: ECO:0000269
product: MODEL1310110025#
modifier: MODEL1310110025#
is: SBO:0000176
reversible: false

metaR RIBt
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
reactant: MODEL1310110025#
is: SBO:0000185
kinetic law: MODEL1310110025#
type: Reaction
name: ribose transport via diffusion

metaR r2373
reactant: MODEL1310110025#
is described by: ECO:0000000
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false
reversible: true
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110025#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110025#_d507a915_3fd0_4578_b50e_0581a2cc18d9
initial amount: NaN
is: P00915
is encoded by: hsa:759
initial concentration: NaN
name: CA1
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
constant: false

metaM CE2838 e
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
type: Species
is: http://identifiers.org/pubchem.compound/5041
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: maltononaose
is: C01936
has only substance units: false
initial concentration: 1.0
constant: false

metaR r0522
product: MODEL1310110025#
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
type: Reaction
reversible: false
modifier: MODEL1310110025#
fast: false
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110025#_bb5ce132_cb97_483f_8cdd_24228604a0ce
name: ACOT6
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:641372
is: Q3I5F7
boundary condition: true
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_d17f0ba2_5acd_45cb_9a2d_4d4d7e4dc8a5
constant: false
is encoded by: hsa:23057
boundary condition: true
initial amount: NaN
name: NMNAT2
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false

metaR PI45P5Pn
fast: false
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase, nuclear
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 2 AUTHORS: PMID:12728269 NOTES:NCD
reactant: MODEL1310110025#
reversible: false
kinetic law: MODEL1310110025#

metaR r0735
product: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000000
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
reversible: true
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110025#_a9153caa_fa13_4d3b_9e7e_4612165438d2
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:92483
constant: false
is: Q9BYZ2
name: LDHAL6B

http://identifiers.org/biomodels.db/MODEL1310110025#_a882b04f_1a29_47a5_89e3_77d560224803
is: P33261
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:1557
is: SBO:0000252
name: CYP2C19

http://identifiers.org/biomodels.db/MODEL1310110025#_8adc27ec_8206_4e2d_a9f2_df3510c0eb66
initial concentration: NaN
is: O43677
type: Species
constant: false
boundary condition: true
name: NDUFC1
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4717
has only substance units: false

metaM udpglcur c
name: UDP-D-glucuronate
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
initial concentration: 1.0
is: SBO:0000247
is: HMDB00935
is: CHEBI:58052
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
is: C00167
constant: false

metaR FAOXC2252053x
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c22:5,n-3 -> c20:5, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/1.3.3.6
name: Beta oxidation of long chain fatty acid
modifier: MODEL1310110025#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110025#
type: Reaction

metaR CHSTEROLtrc
reversible: true
is: SBO:0000185
name: transport of cholesterol into the cytosol
is described by: ECO:0000134
product: MODEL1310110025#
reactant: MODEL1310110025#
fast: false
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
type: Reaction

metaM mlthf c
is: C00143
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01533
is: CHEBI:15636
name: 5,10-Methylenetetrahydrofolate
type: Species
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
has only substance units: false

metaR r0937
name: Transport reaction
kinetic law: MODEL1310110025#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110025#
product: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_91b4e894_86d4_4bb1_831f_54a6b628f898
initial concentration: NaN
is: F8WDN9
boundary condition: true
name: PPA2
is encoded by: hsa:27068
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
constant: false

metaM mescon m
has only substance units: false
is: CHEBI:36986
is: HMDB00749
is: SBO:0000247
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
name: Mesaconate
boundary condition: false

metaM amp x
is: HMDB00045
constant: false
type: Species
has only substance units: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: CHEBI:456215
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: C00020
name: AMP
initial amount: NaN

metaM HC02213 e
is: CHEBI:28031
boundary condition: false
name: prostaglandin-e3
has only substance units: false
type: Species
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR PVD3
product: MODEL1310110025#
is: SBO:0000176
kinetic law: MODEL1310110025#
name: Previtamin D3 formation
reversible: true
type: Reaction
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:6281884 NOTES:This reaction takes place in skin and needs UV 290-305. based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
fast: false
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110025#_92ba3b98_e6e3_436d_99f8_2c056b9e5064
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:3033
is: Q16836
boundary condition: true
name: HADH

metaM leu L e
has only substance units: false
initial amount: NaN
is: CHEBI:15603
is: HMDB00687
initial concentration: 1.0
boundary condition: false
name: L-leucine
is: SBO:0000247
constant: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
type: Species

metaR DM 4abut LPAREN n RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: PMID: 16643338 NOTES:GABA in the intestine may aid in differentiation and proliferation of epithelial cells. GABA intake by oral administration has been shown to alleviate stress, worry and anxiety and additionally it can also improve human immunity (PMID: 16971751). However the PAT1 transporter located at the apical side of enterocytes have very low affinity for GABA. I have presumed that this oral GABA is used within intestine (unless administered at high very high pharmacological doses, GABA exit from the enterocytes may be mediated by other specifc transporters).
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for 4-Aminobutanoate(n)
type: Reaction

metaR r0734
kinetic law: MODEL1310110025#
reversible: false
fast: false
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is: SBO:0000176
reactant: MODEL1310110025#
product: MODEL1310110025#
type: Reaction

metaR G5SADrm
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000000
reversible: true
product: MODEL1310110025#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD
is: SBO:0000176

metaM dolmanp U c
name: Dolichyl phosphate D-mannose, human uterine homolog
initial amount: NaN
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
is: SBO:0000247
type: Species
is: CHEBI:15809
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaR ADMDC
type: Reaction
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.1.1.50
reactant: MODEL1310110025#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (262.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.1.50 Confidence Level: 4 AUTHORS: PMID:2460457 NOTES:
name: adenosylmethionine decarboxylase
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110025#_48304825_6473_4026_8774_9a769823205f
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AI769281
constant: false
initial amount: NaN
boundary condition: true
name: _AI769281_1_e
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_08138d99_4aa2_49a8_8802_04f17037302b
is: Q9NRA0
type: Species
constant: false
boundary condition: true
is encoded by: hsa:56848
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: SPHK2

metaR r0149
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.14.13.39
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
kinetic law: MODEL1310110025#
fast: false
reactant: MODEL1310110025#
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110025#_c68aea0b_a7da_4951_8d85_43de12a8ce48
initial amount: NaN
is encoded by: hsa:2222
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
name: FDFT1
has only substance units: false
is: P37268

metaM 2hb e
is: HMDB00008
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:1148
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
name: 2-Hydroxybutyrate

metaM fol e
initial amount: NaN
constant: false
is: HMDB00121
notes: FORMULA: C19H18N7O6 CHARGE: -1
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
name: Folate

http://identifiers.org/biomodels.db/MODEL1310110025#_a7726d23_455d_4464_bb02_5ae559343224
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: Q9H6Y6
boundary condition: true
name: MYO5B
has only substance units: false
is encoded by: hsa:4645
type: Species

metaM ump n
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: HMDB00288
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:57865
initial amount: NaN
name: UMP(2-)
initial concentration: 1.0
has only substance units: false
type: Species

metaM so4 m
type: Species
name: sulfate
constant: false
is: HMDB01448
boundary condition: false
has only substance units: false
is: CHEBI:16189
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059

metaR RE3421R
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
type: Reaction
name: RE3421
reversible: true
kinetic law: MODEL1310110025#
is described by: ECO:0000000
reactant: MODEL1310110025#
fast: false
is: SBO:0000176
product: MODEL1310110025#

metaR r0936
reversible: false
reactant: MODEL1310110025#
product: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Transport reaction
kinetic law: MODEL1310110025#
is described by: ECO:0000000
is: SBO:0000185
fast: false

metaR r2031
kinetic law: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110025#
type: Reaction
product: MODEL1310110025#
is: SBO:0000185
reactant: MODEL1310110025#
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000

metaM HC00900 c
has only substance units: false
is: SBO:0000247
is: CHEBI:30860
boundary condition: false
type: Species
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
name: Methylmalonate
initial amount: NaN
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110025#_1a29987c_3c70_4568_8647_2ef13eb77234
is: SBO:0000252
is: P00439
name: PAH
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:5053
type: Species
boundary condition: true

metaM 6pgc r
is: HMDB01316
boundary condition: false
initial concentration: 1.0
is: CHEBI:58759
has only substance units: false
type: Species
notes: FORMULA: C6H10O10P CHARGE: -3 INCHI: InChI=1S/C6H13O10P/c7-2(1-16-17(13,14)15)3(8)4(9)5(10)6(11)12/h2-5,7-10H,1H2,(H,11,12)(H2,13,14,15)/p-3/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00292 EHMN_ABBREVIATION: C00345
is: SBO:0000247
name: 6-phosphonatooxy-D-gluconate
initial amount: NaN
constant: false

metaR r2371
is: SBO:0000185
reactant: MODEL1310110025#
is described by: ECO:0000000
product: MODEL1310110025#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110025#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction

metaM 2mb2coa m
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
initial concentration: 1.0
is: HMDB02054
has only substance units: false
name: 2-methylcrotonoyl-CoA(4-)
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:57337
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_65a318db_b412_42fa_aef9_7c8efcac026a
name: DGUOK
is encoded by: hsa:1716
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: E5KSL5
initial amount: NaN
boundary condition: true

metaR r0426
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.5.1.34
reversible: true
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
kinetic law: MODEL1310110025#
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3

metaR PROSTGE2t
type: Reaction
name: prostaglandin transport via bicarbonate countertransport
fast: false
reversible: true
reactant: MODEL1310110025#
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
is described by: ECO:0000269
product: MODEL1310110025#
is: SBO:0000185
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110025#_bf6025c3_3b46_402e_83b8_645c2297d2b8
name: PCBD1
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:5092
initial amount: NaN
is: P61457

http://identifiers.org/biomodels.db/MODEL1310110025#_87bbe403_3303_48a0_8591_08f1af07ba89
is encoded by: hsa:5167
boundary condition: true
has only substance units: false
initial amount: NaN
is: P22413
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
name: ENPP1

metaM HC02213 c
name: prostaglandin-e3
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:28031

metaR r0527
kinetic law: MODEL1310110025#
type: Reaction
is described by: ECO:0000000
reversible: true
product: MODEL1310110025#
name: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:
reactant: MODEL1310110025#
is: SBO:0000176
fast: false

metaR EX thr L LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Threonine exchange
type: Reaction

metaR APOC LYS BTNP
type: Reaction
product: MODEL1310110025#
name: proteolysis of apoC-Lys-btn
kinetic law: MODEL1310110025#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000176
fast: false
reversible: false
reactant: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_c85c7308_7fdb_4683_bfce_f681115abbd7
name: MUT
constant: false
has only substance units: false
type: Species
is encoded by: hsa:4594
is: P22033
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR SBT Dtde
reactant: MODEL1310110025#
is described by: ECO:0000134
reversible: true
is: SBO:0000185
product: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
name: D-sorbitol transport, extracellular
type: Reaction
kinetic law: MODEL1310110025#

metaM acgal c
is: CHEBI:28037
is: SBO:0000247
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB00212
name: N-acetyl-D-galactosamine
type: Species
boundary condition: false
initial amount: NaN

metaR NTP3e
reversible: false
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/3.6.1.6
type: Reaction
fast: false
is described by: ECO:0000269
product: MODEL1310110025#
is: SBO:0000176
reactant: MODEL1310110025#
name: nucleoside-triphosphatase (GTP)
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.15 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
modifier: MODEL1310110025#

metaM dag hs c
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:18035
type: Species
constant: false
has only substance units: false
name: diglyceride
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0

metaR r2376
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110025#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110025#
product: MODEL1310110025#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_85597b83_4eaf_4832_95ed_dd563782544f
is: SBO:0000297
initial concentration: NaN
is encoded by: hsa:8875
has part: O95498
constant: false
name: VNN3:VNN2:VNN1
boundary condition: true
has only substance units: false
is encoded by: hsa:55350
type: Species
initial amount: NaN

metaR r0425
kinetic law: MODEL1310110025#
is: SBO:0000176
type: Reaction
name: EC:1.1.1.42
is described by: ECO:0000000
product: MODEL1310110025#
fast: false
is version of: http://identifiers.org/ec-code/1.17.1.4
modifier: MODEL1310110025#
reversible: true
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:18484410,PMID:9866202 NOTES:
reactant: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_6a0c5f9e_340f_48bd_b467_f9c3f35e0fbf
name: PPA2
is encoded by: hsa:27068
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false

metaM 4mop c
name: 4-methyl-2-oxopentanoate
is: CHEBI:17865
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
has only substance units: false
initial concentration: 1.0
is: HMDB00695
boundary condition: false
constant: false
type: Species

metaR TSTSTERONEt
is: SBO:0000185
type: Reaction
reactant: MODEL1310110025#
is described by: ECO:0000269
fast: false
name: Testosterone transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.8.2.2 Confidence Level: 2 AUTHORS: PMID:1588921,PMID:16399349 NOTES:
reversible: true
product: MODEL1310110025#
kinetic law: MODEL1310110025#

metaM but c
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB00039
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
is: CHEBI:17968
name: butyrate
is: SBO:0000247
initial concentration: 1.0
type: Species

metaM ametam c
is: HMDB00988
initial amount: NaN
type: Species
name: S-Adenosylmethioninamine
is: CHEBI:57443
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C14H24N6O3S CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00683 EHMN_ABBREVIATION: C01137
has only substance units: false
is: C01137
initial concentration: 1.0

metaR TRDR
reversible: false
reactant: MODEL1310110025#
modifier: MODEL1310110025#
is described by: ECO:0000269
name: thioredoxin reductase (NADPH)
is: SBO:0000176
fast: false
product: MODEL1310110025#
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/1.8.1.9

metaM sph1p e
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
is: CHEBI:57939
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
is: SBO:0000247
is: HMDB01383
type: Species
initial amount: NaN

metaR ADNK1m
is: SBO:0000176
reversible: false
reactant: MODEL1310110025#
product: MODEL1310110025#
fast: false
name: adenosine kinase, mitochondrial
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.20 Confidence Level: 1 AUTHORS: NOTES:IT
is described by: ECO:0000000
type: Reaction

metaM atp n
is: SBO:0000247
name: ATP(3-)
is: CHEBI:57299
initial amount: NaN
is: HMDB00538
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
type: Species

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

metaR ACCOAC
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

metaR MEVK1c
is: SBO:0000176
modifier: MODEL1310110025#
fast: false
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (4598.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book.
type: Reaction
name: mevalonate kinase (atp) cytosol
is version of: http://identifiers.org/ec-code/2.7.1.36
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
is described by: ECO:0000134
reversible: false

metaR SUCOAS1m
reversible: true
fast: false
type: Reaction
name: Succinate--CoA ligase (GDP-forming)
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/6.2.1.4
product: MODEL1310110025#
reactant: MODEL1310110025#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
kinetic law: MODEL1310110025#

metaM ppi e
name: Diphosphate
is: CHEBI:33019
type: Species
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
is: C00013
is: HMDB00250
initial amount: NaN
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013

metaR r0365
product: MODEL1310110025#
reactant: MODEL1310110025#
reversible: false
is: SBO:0000176
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59
fast: false
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.1.72
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#

metaR r2377
is described by: ECO:0000000
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reversible: true
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false

metaR FATP3t
reversible: true
product: MODEL1310110025#
is: SBO:0000185
reactant: MODEL1310110025#
is described by: ECO:0000269
type: Reaction
name: fatty acid electroneutral transport
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
fast: false

metaM dag hs e
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
is: SBO:0000247
boundary condition: false
is: CHEBI:18035
name: diglyceride
constant: false

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

metaR SPRMS
reactant: MODEL1310110025#
type: Reaction
name: spermine synthase
is version of: http://identifiers.org/ec-code/2.5.1.22
product: MODEL1310110025#
is: SBO:0000176
fast: false
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (6611.1) SUBSYSTEM: Urea cycle EC Number: 2.5.1.22 Confidence Level: 4 AUTHORS: PMID:7546290 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110025#_2800bfb8_d86b_4ff6_a9bf_1f448fd2d09b
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
name: IMPDH1
is: C9JV30
initial concentration: NaN
constant: false
is encoded by: hsa:3614

metaR r0424
reversible: true
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
fast: false
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is: SBO:0000176
product: MODEL1310110025#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.17.1.4

http://identifiers.org/biomodels.db/MODEL1310110025#_2f39fc2a_eb51_4df2_b65d_2c2fb7660b3e
is encoded by: hsa:8310
name: ACOX3
boundary condition: true
initial concentration: NaN
is: O15254
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_44b274f4_5888_4ff9_9191_c1a9858d8e6b
is: P17568
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:4713
boundary condition: true
is: SBO:0000252
name: NDUFB7
constant: false
initial amount: NaN

metaM dctp c
is: HMDB00998
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: C00458
has only substance units: false
constant: false
name: dCTP
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: CHEBI:16311
type: Species

metaR H2CO3D
is: SBO:0000176
name: carboxylic acid dissociation
reactant: MODEL1310110025#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110025#
reversible: true
notes: GENE_ASSOCIATION: (761.1) or (771.1) or (377677.1) or (762.1) or (766.2) or (23632.1) or (766.1) or (771.2) or (759.1) or (768.1) or (760.1) SUBSYSTEM: Miscellaneous EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:11101628,PMID:11172051,PMID:11676494,PMID:14600151,PMID:7574487 NOTES:tv
product: MODEL1310110025#
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/4.2.1.1
type: Reaction

metaR biomass reaction
type: Reaction
name: Generic human biomass reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110025#
fast: false
reversible: false
kinetic law: MODEL1310110025#
is described by: ECO:0000134
is: SBO:0000185
product: MODEL1310110025#

metaM dhap m
is: C00111
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
name: Dihydroxyacetone phosphate
is: HMDB01473
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3411

http://identifiers.org/biomodels.db/MODEL1310110025#_15381737_91ae_4ccb_b483_461e238b4862
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
has only substance units: false
is encoded by: hsa:11001
boundary condition: true
is: O14975
initial concentration: NaN
name: SLC27A2

metaM thbpt c
boundary condition: false
is: HMDB00027
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
name: 5,6,7,8-tetrahydrobiopterin
is: CHEBI:15372
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false

metaM atp m
type: Species
is: C00002
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: ATP(4-)
has only substance units: false
is: HMDB00538
is: CHEBI:57299
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_329c41f8_5fcd_47e6_b06e_e44e79361307
is: SBO:0000252
constant: false
is encoded by: hsa:80055
initial amount: NaN
type: Species
initial concentration: NaN
name: PGAP1
is: Q75T13
has only substance units: false
boundary condition: true

metaR r2374
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110025#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
reactant: MODEL1310110025#
product: MODEL1310110025#

metaR r0311
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
fast: false
product: MODEL1310110025#
is: SBO:0000176
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
modifier: MODEL1310110025#
is described by: ECO:0000000
kinetic law: MODEL1310110025#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.9
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16

metaM malttr e
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
is: C01835
is: SBO:0000247
is: CHEBI:27931
is: HMDB01262
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
name: maltotriose

metaM cspg b e
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
is: HMDB00630
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
initial concentration: 1.0
is: CHEBI:16040
is: SBO:0000247

metaR LPS2
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (4023.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.3 Confidence Level: 4 AUTHORS: PMID:1969408 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/3.1.1.34
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110025#
name: lipase

http://identifiers.org/biomodels.db/MODEL1310110025#_a5629341_baf9_4766_8066_bbbb0f6c2ccb
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:123041
is: Q8NFF2
type: Species
initial concentration: NaN
boundary condition: true
name: SLC24A4
constant: false

metaR ADCim
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 4.1.1.4 Confidence Level: 2 AUTHORS: NOTES:TDV (Voet & Voet pg 581) Non-enzymatic decarboxylation; spontaneous reaction added "m" suffix - NCD
is: SBO:0000176
name: Acetoacetate decarboxylation (irreversible), mitochondrial
fast: false
reversible: false
reactant: MODEL1310110025#
product: MODEL1310110025#
kinetic law: MODEL1310110025#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110025#_49d1e800_46c9_4633_a84c_bff257675a3f
type: Species
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:285973
boundary condition: true
name: ATG9B
is: SBO:0000252
initial concentration: NaN
is: Q674R7

metaR 10FTHFtm
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
product: MODEL1310110025#
is: SBO:0000185
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD

metaR EX pglyc hs LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylglycerol (homo sapiens) exchange
type: Reaction

metaM chlstol r
is: HMDB06842
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
has only substance units: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
name: 5alpha-cholesta-7,24-dien-3beta-ol
boundary condition: false
initial concentration: 1.0
is: CHEBI:16290

http://identifiers.org/biomodels.db/MODEL1310110025#_6543ba29_03e2_49fb_9ba7_c4ec9cd02658
is encoded by: hsa:3074
type: Species
constant: false
has part: P06865
boundary condition: true
is: SBO:0000297
has part: P07686
name: HEXA:HEXB
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3073

metaM but e
initial amount: NaN
is: HMDB00039
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:17968
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
name: butyrate
constant: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110025#_b90a593d_4689_4c79_9734_9030f4592d9c
constant: false
boundary condition: true
name: PEMT
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10400
is: Q9UBM1

http://identifiers.org/biomodels.db/MODEL1310110025#_ab29916a_6a3c_4b31_a309_0ffea7852988
name: MECR
type: Species
constant: false
is encoded by: hsa:51102
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: Q9BV79

http://identifiers.org/biomodels.db/MODEL1310110025#_d7a58d23_6660_42d2_ac12_956302f0ddea
name: IMPA2
is: O14732
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:3613

http://identifiers.org/biomodels.db/MODEL1310110025#_d0e6a3a8_70c2_4553_b3cb_af808d5bd511
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: PDE8A
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:5151
constant: false
is: O60658

http://identifiers.org/biomodels.db/MODEL1310110025#_16133075_4053_45ed_8598_843aaf44c36d
is: Q969I6
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:55089
name: SLC38A4

metaM 5dhf e
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
has only substance units: false
type: Species
is: HMDB06487
constant: false
name: pentaglutamyl folate (DHF)
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110025#_ca7d6e04_ca7c_4518_bd28_89ae97686062
name: AMY2A
boundary condition: true
constant: false
is: P04746
is: SBO:0000252
has only substance units: false
is encoded by: hsa:279
initial amount: NaN
type: Species
initial concentration: NaN

metaM abt e
is: HMDB01851
name: L-arabinitol
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:18403
initial amount: NaN
type: Species
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532

metaM phe L c
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
initial amount: NaN
name: L-phenylalanine
boundary condition: false
is: CHEBI:17295
is: HMDB00159
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_cd1fd799_8e61_4e9b_98d4_2c6cd3ae2c8c
initial concentration: NaN
is: SBO:0000252
name: HMGCS2
type: Species
constant: false
has only substance units: false
is encoded by: hsa:3158
initial amount: NaN
boundary condition: true
is: P54868

metaM sph1p c
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
is: CHEBI:57939
is: HMDB01383
is: SBO:0000247

metaR CYSO
name: cysteine oxidase
notes: GENE_ASSOCIATION: (1036.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES:IT
type: Reaction
is version of: http://identifiers.org/ec-code/1.13.11.20
fast: false
modifier: MODEL1310110025#
is described by: ECO:0000269
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reactant: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_d3ff89f9_482a_4059_a196_7a37397e480e
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: PYCRL
is: Q53H96
is encoded by: hsa:65263
boundary condition: true
constant: false
type: Species

metaR r0423
kinetic law: MODEL1310110025#
fast: false
product: MODEL1310110025#
is: SBO:0000176
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
modifier: MODEL1310110025#
reactant: MODEL1310110025#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42

metaR r0310
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
type: Reaction
product: MODEL1310110025#
name: Palmitoyl-CoA:oxygen 2-oxidoreductase Fatty acid metabolism EC:1.3.3.6 EC:1.3.99.3
kinetic law: MODEL1310110025#
reversible: false
reactant: MODEL1310110025#
is: SBO:0000176
is described by: ECO:0000000
fast: false

metaR r2375
fast: false
reactant: MODEL1310110025#
product: MODEL1310110025#
reversible: true
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110025#

metaM ppi c
initial amount: NaN
name: Diphosphate
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: HO7P2 CHARGE: -3
is: C00013
is: HMDB00250
is: CHEBI:0

http://identifiers.org/biomodels.db/MODEL1310110025#_540290b8_aaba_4ffe_b7af_a3342b7db987
initial concentration: NaN
constant: false
type: Species
name: ADH4
boundary condition: true
has only substance units: false
is: SBO:0000252
is: P08319
is encoded by: hsa:127
initial amount: NaN

metaR PDE1
product: MODEL1310110025#
name: 3',5'-cyclic-nucleotide phosphodiesterase
is: SBO:0000176
is described by: ECO:0000269
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.17
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/3.1.4.35
fast: false
notes: GENE_ASSOCIATION: (5139.1) or (5142.1) or (5151.3) or (5153.1) or (5150.2) or (5143.1) or (5150.1) or (5137.1) or (5144.1) or (5136.2) or (5140.2) or (5151.2) or (10846.1) or (5151.5) or (5140.1) or (5141.1) or (5138.1) or (5136.1) or (5151.4) or (5151.1) or (27115.1) or (50940.1) or (8622.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10725373,PMID:10872825,PMID:10906126,PMID:10952971,PMID:11050148,PMID:11114167,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12388353,PMID:12681444,PMID:12764607,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8884271,PMID:9210593,PMID:9419816 NOTES:NCD

metaR r0931
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
name: Transport reaction
type: Reaction
reversible: false
kinetic law: MODEL1310110025#
is described by: ECO:0000000
reactant: MODEL1310110025#
fast: false

metaR EX udp LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP exchange
type: Reaction

metaM HC02175 e
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
name: caprate
boundary condition: false
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
is: CHEBI:27689

metaR NDP3ex
reversible: false
fast: false
name: nucleoside-diphosphatase (GDP), extracellular
is: SBO:0000176
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:EC is 3.6.1.42? NCD
kinetic law: MODEL1310110025#
is described by: ECO:0000269
product: MODEL1310110025#
modifier: MODEL1310110025#
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/3.6.1.6
type: Reaction

metaR PIt8
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
reversible: true
name: phosphate transport in/out via Na+ symporter
kinetic law: MODEL1310110025#
is: SBO:0000185
product: MODEL1310110025#
reactant: MODEL1310110025#
fast: false
type: Reaction
is described by: ECO:0000006

metaR EX gam LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Glucosamine
type: Reaction

metaM ppi r
is: CHEBI:33019
name: Diphosphate
is: C00013
is: SBO:0000247
type: Species
is: HMDB00250
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false

metaR r1527
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110025#
is: SBO:0000185
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
reversible: false
fast: false
kinetic law: MODEL1310110025#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/4.2.1.1

metaR HSD3A2r
fast: false
product: MODEL1310110025#
reactant: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
is: SBO:0000176
kinetic law: MODEL1310110025#
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.225
modifier: MODEL1310110025#
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)

metaM 7dhf e
name: heptaglutamyl folate (DHF)
is: HMDB06559
type: Species
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1

metaM HC01409 m
constant: false
is: CHEBI:27540
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h14-16,20-22,26,37-38H,4-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05270
name: Hexanoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110025#_08d715cc_ed30_47ea_9a79_3df62b3b9237
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:7296
type: Species
initial concentration: NaN
name: TXNRD1
boundary condition: true

metaR Htg
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110025#
type: Reaction
is described by: ECO:0000000
fast: false
name: proton diffusion (Golgi)
is: SBO:0000185
reactant: MODEL1310110025#
product: MODEL1310110025#

metaR R group phosphotase 2
reactant: MODEL1310110025#
product: MODEL1310110025#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110025#
fast: false
is: SBO:0000176
name: R group phosphotase 2
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_45dc0ce4_38cf_4b36_a6cb_618201e2f619
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: NUDT12
type: Species
initial concentration: NaN
is: Q9BQG2
is encoded by: hsa:83594

http://identifiers.org/biomodels.db/MODEL1310110025#_0be72196_2aa2_40f3_afb2_7fe290a67d06
initial amount: NaN
boundary condition: true
name: _AI090874_1_c
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AI090874
is: SBO:0000252
constant: false

metaM 5adtststerone c
type: Species
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
initial amount: NaN
is: CHEBI:16330
is: HMDB02961
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
name: 17beta-hydroxy-5alpha-androstan-3-one

metaR r0317
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.4.4.2
is: SBO:0000176
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
kinetic law: MODEL1310110025#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.4
reversible: true
product: MODEL1310110025#
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.1.2.10

http://identifiers.org/biomodels.db/MODEL1310110025#_72c9c6f4_0327_415b_aca9_2ea52bb089fc
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:54677
name: CROT
has only substance units: false
type: Species
initial concentration: NaN
is: E7EQF2
is: SBO:0000252

metaR DCK1n
name: Deoxycytidine kinase, nuclear (ATP)
product: MODEL1310110025#
reactant: MODEL1310110025#
type: Reaction
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.74
is: SBO:0000176
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_d0cc1b9f_8ea7_4788_a054_6a1b813f50f9
is: Q9BV10
name: ALG12
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:79087

metaM bildglcur c
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: bis(beta-glucosyluronate)bilirubin
is: CHEBI:58471
type: Species
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
is: HMDB03325

metaR EX vitd3 LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for calctriol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_b2c1a4a0_7618_4371_8e9e_36f6b9e69353
type: Species
is encoded by: hsa:5283
name: PIGH
boundary condition: true
initial amount: NaN
has only substance units: false
is: Q14442
is: SBO:0000252
initial concentration: NaN
constant: false

metaR r1679
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110025#
reversible: false
kinetic law: MODEL1310110025#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
fast: false
product: MODEL1310110025#
is: SBO:0000185
reactant: MODEL1310110025#

metaM CE2422 m
has only substance units: false
is: CHEBI:28387
type: Species
initial amount: NaN
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA
boundary condition: false
constant: false
is: HMDB11123
initial concentration: 1.0
is: SBO:0000247

metaR EX fe3 LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Fe3+ exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_556be4be_165d_4424_9c32_4419b502c379
is: Q92947
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:2639
initial amount: NaN
name: GCDH

http://identifiers.org/biomodels.db/MODEL1310110025#_58feb7e2_2d17_494c_955d_81e684396c54
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:29988
name: SLC2A8
has only substance units: false
is: SBO:0000252
boundary condition: true
is: Q9NY64

metaM amp m
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: CHEBI:456215
has only substance units: false
name: AMP(2-)
is: HMDB00045
initial concentration: 1.0
type: Species

metaR HCO3 CLt
is: SBO:0000185
reversible: true
name: bicarbonate transport (Cl-/HCO3- exchange)
product: MODEL1310110025#
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
type: Reaction
modifier: MODEL1310110025#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (6522.1) or (83697.1) or (6521.1) or (6508.2) or (6508.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11302728,PMID:12027221,PMID:14722772 NOTES:MM

metaR O2St
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
reversible: true
is: SBO:0000185
name: superoxide anion transport via diffusion (extracellular)
is described by: ECO:0000000
type: Reaction
product: MODEL1310110025#
fast: false
kinetic law: MODEL1310110025#

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

metaM chsterol m
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:16113
name: cholesterol
is: HMDB00067
initial amount: NaN
boundary condition: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_7a88fa89_7031_4871_b048_9df91d2cbc90
initial amount: NaN
is encoded by: hsa:220
is: P47895
name: ALDH1A3
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

metaM leu L m
name: L-leucine
is: HMDB00687
constant: false
type: Species
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:15603
initial concentration: 1.0

metaR r2378
fast: false
reversible: true
kinetic law: MODEL1310110025#
product: MODEL1310110025#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_e7f7cc76_9caf_428b_b350_7f61408ca5bd
boundary condition: true
is encoded by: hsa:1375
is: SBO:0000252
initial concentration: NaN
constant: false
name: CPT1B
initial amount: NaN
type: Species
is: E9PCP2
has only substance units: false

metaM malcoa c
boundary condition: false
constant: false
is: CHEBI:57384
is: SBO:0000247
is: C00083
type: Species
initial concentration: 1.0
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
initial amount: NaN
name: Malonyl-CoA
is: HMDB01175
has only substance units: false

metaM prostgi2 e
is: CHEBI:57403
is: HMDB01335
is: SBO:0000247
name: prostaglandin I2(1-)
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
boundary condition: false

metaM icit x
constant: false
initial concentration: 1.0
boundary condition: false
name: isocitrate(3-)
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:16087
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
is: HMDB00193

metaM atp r
name: ATP(4-)
boundary condition: false
is: C00002
is: HMDB00538
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:57299
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_151264d4_a485_4911_9ea8_08b31560e266
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:AA526438
name: _AA526438_1_c
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species

metaR EX xylt LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for xylitol
type: Reaction

metaR r0634
reactant: MODEL1310110025#
reversible: true
product: MODEL1310110025#
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is: SBO:0000176
modifier: MODEL1310110025#
type: Reaction
fast: false
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/3.1.4.1
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110025#_e76a655c_b62d_4abf_a7cb_c161b5961f43
initial amount: NaN
type: Species
has only substance units: false
is: O60760
initial concentration: NaN
name: HPGDS
is: SBO:0000252
is encoded by: hsa:27306
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_1365d480_2b41_42f8_93e3_835cfb73a514
type: Species
boundary condition: true
name: CRAT
is encoded by: hsa:1384
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_316935d0_f67c_49b2_ac10_df0cdf34c813
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:AI469183
name: _AI469183_1_x
is: SBO:0000252
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_c71a1a2d_720f_4e3b_9fd3_086730cb2f23
initial amount: NaN
type: Species
name: _R51273_1_c
boundary condition: true
constant: false
is encoded by: hsa:R51273
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaM chsterol l
is: CHEBI:16113
name: cholesterol
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
has only substance units: false
is: HMDB00067
boundary condition: false
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaR r2379
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
is: SBO:0000185
reversible: true
reactant: MODEL1310110025#

metaM trdrd c
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
boundary condition: false
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
has only substance units: false
is: CHEBI:15967
is: C00342
name: Reduced thioredoxin

metaM bildglcur e
is: HMDB03325
name: bis(beta-glucosyluronate)bilirubin
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
is: CHEBI:58471
boundary condition: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_c878199a_eed6_4c0f_b5cb_73f071b1dd4e
has only substance units: false
boundary condition: true
is encoded by: hsa:23539
name: SLC16A8
constant: false
is: O95907
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR PIACGT
kinetic law: MODEL1310110025#
name: phosphatidylinositol N-acetylglucosaminyltransferase
modifier: MODEL1310110025#
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.4.1.198
is described by: ECO:0000000
product: MODEL1310110025#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.83
fast: false
notes: GENE_ASSOCIATION: (5279.1) and (51227.2) and (5283.1) and (5277.2) and (9091.1) and (8818.1) or (5279.1) and (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) or (51227.1) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.2) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (5279.2) and (8818.1) or (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.1) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.2) or (51227.1) and (5277.1) and (5283.1) and (9091.1) and (5279.2) and (8818.1) or (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (9091.2) and (5277.3) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (8818.2) and (5279.2) or (5279.1) and (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.2) or (51227.1) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.2) and (9091.2) and (5277.1) and (5283.1) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.2) and (5283.1) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (5283.1) and (5277.2) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (5283.1) and (5277.2) and (9091.1) and (8818.2) or (51227.3) and (9091.2) and (5283.1) and (5277.2) and (5279.2) and (8818.1) or (5279.1) and (51227.3) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (51227.1) and (9091.2) and (5277…
reversible: false
type: Reaction

metaM frdp x
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:175763
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: HMDB00961
constant: false
name: farnesyl pyrophosphate(3-)
has only substance units: false
type: Species

metaR PIt7
type: Reaction
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
name: phosphate transport in/out via three Na+ symporter
is described by: ECO:0000269

metaM dctp n
is: HMDB00998
constant: false
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: C00458
boundary condition: false
type: Species
name: dCTP
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16311
has only substance units: false
initial amount: NaN

metaR GLCAASE9ly
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
fast: false
is described by: ECO:0000269
name: beta-glucuronidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.31
type: Reaction
modifier: MODEL1310110025#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
product: MODEL1310110025#
reversible: false

metaM HC00591 m
initial amount: NaN
is: SBO:0000247
type: Species
name: 2-oxoglutaramate
constant: false
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:16769

metaM dhap x
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
is: http://identifiers.org/pubchem.compound/3411
is: CHEBI:57642
is: HMDB01473
is: C00111
initial amount: NaN
name: Dihydroxyacetone phosphate

metaR r0633
is version of: http://identifiers.org/ec-code/2.7.7.3
modifier: MODEL1310110025#
type: Reaction
is described by: ECO:0000000
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
product: MODEL1310110025#
fast: false
kinetic law: MODEL1310110025#
reversible: true
reactant: MODEL1310110025#
is: SBO:0000176

metaM acnam c
boundary condition: false
has only substance units: false
is: HMDB00230
is: CHEBI:35418
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
initial amount: NaN
initial concentration: 1.0
name: N-acetylneuraminate

http://identifiers.org/biomodels.db/MODEL1310110025#_effb174c_a241_4d71_97e5_94b813cc8ae8
name: PIPOX
is encoded by: hsa:51268
constant: false
initial amount: NaN
is: Q9P0Z9
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_4271fa65_187b_48a9_a33a_3feb463e298e
is encoded by: hsa:3098
name: HK1
type: Species
initial amount: NaN
is: P78542
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR R group phosphotase 1
reversible: false
product: MODEL1310110025#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110025#
is: SBO:0000176
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
name: R group phosphotase 1

metaR FE3MTP1
name: transport of ferrous iron into blood
kinetic law: MODEL1310110025#
is: SBO:0000185
modifier: MODEL1310110025#
fast: false
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (30061.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
is described by: ECO:0000134
product: MODEL1310110025#
type: Reaction
reversible: false

metaM prostgi2 c
is: HMDB01335
name: prostaglandin I2(1-)
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57403
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
constant: false
type: Species

metaM ppi n
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial amount: NaN
is: SBO:0000247
is: CHEBI:33019
initial concentration: 1.0
type: Species
is: HMDB00250
name: diphosphate(3-)
constant: false
has only substance units: false
boundary condition: false

metaR SO4tl
kinetic law: MODEL1310110025#
reversible: true
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110025#
name: Sulfate transport (lysosome)
product: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
is: SBO:0000185

metaR MAGt
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:10344773 NOTES:
product: MODEL1310110025#
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
reversible: true
fast: false
name: monoacylglycerol 2 transport
is: SBO:0000185
is described by: ECO:0000269

metaR APOC LYS BTNPm
name: proteolysis of apoC-Lys-btn, mitochondrial
is described by: ECO:0000000
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
is: SBO:0000176
fast: false
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110025#_6546d59b_e27b_45d2_b9cc_ca7e9e1331b7
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1329
boundary condition: true
constant: false
name: COX5B
initial amount: NaN
type: Species
is: Q53YB7
initial concentration: NaN

metaR ALADGLYexR
type: Reaction
fast: false
reversible: true
is: SBO:0000185
name: D-alanine/glycine reversible exchange
product: MODEL1310110025#
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110025#_244320f4_71c0_4ded_bd97_e760591d95cd
type: Species
initial concentration: NaN
is encoded by: hsa:9154
boundary condition: true
initial amount: NaN
is: O00337
is: SBO:0000252
has only substance units: false
constant: false
name: SLC28A1

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

metaM atp x
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:57299
type: Species
name: ATP(4-)
is: C00002
boundary condition: false
is: HMDB00538
initial amount: NaN

metaR C3STKR2r
fast: false
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER - NJ
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/4.2.1.107
name: C-3 sterol keto reductase (zymosterol)
type: Reaction
reactant: MODEL1310110025#
product: MODEL1310110025#
kinetic law: MODEL1310110025#
reversible: false
is: SBO:0000176

metaR RE1447N
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
kinetic law: MODEL1310110025#
type: Reaction
is: SBO:0000176
fast: false
name: RE1447
product: MODEL1310110025#

metaM amp r
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
initial concentration: 1.0
type: Species
name: AMP
is: HMDB00045
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:456215
is: C00020
boundary condition: false
initial amount: NaN

metaM h2o x
is: HMDB02111
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:15377
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
type: Species
name: H2O
is: C00001

http://identifiers.org/biomodels.db/MODEL1310110025#_122a608b_b59c_4e1c_a01c_ae6f15861a81
is encoded by: hsa:7371
is: SBO:0000252
is: Q9BZX2
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
type: Species
boundary condition: true
name: UCK2

metaM ppi m
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:33019
type: Species
is: C00013
name: Diphosphate
is: HMDB00250

metaR r2142
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110025#
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110025#
reactant: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110025#

metaR NTD11
reversible: false
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (22978.1) or (93034.2) or (93034.1) SUBSYSTEM: Purine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.5
is described by: ECO:0000269
reactant: MODEL1310110025#
product: MODEL1310110025#
fast: false
name: 5'-nucleotidase (IMP)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_25cef13a_b87f_4453_9b24_9b954a39ee20
has only substance units: false
initial amount: NaN
is encoded by: hsa:23632
boundary condition: true
is: A8K3J4
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
name: CA14

metaR EX ha LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_85246a2e_e916_486c_bd3d_ab246bd0a074
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
is: Q8TD20
initial amount: NaN
name: SLC2A12
is encoded by: hsa:154091
boundary condition: true

metaM gam6p c
constant: false
initial concentration: 1.0
is: CHEBI:12962
name: D-Glucosamine 6-phosphate
is: SBO:0000247
notes: FORMULA: C6H13NO8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00298 EHMN_ABBREVIATION: C00352
initial amount: NaN
boundary condition: false
type: Species
is: HMDB01254
has only substance units: false

metaM frdp r
is: C00448
constant: false
has only substance units: false
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
type: Species
is: SBO:0000247
boundary condition: false
name: Farnesyl diphosphate
initial concentration: 1.0
is: HMDB00961
is: CHEBI:175763
initial amount: NaN

metaR q10h2tc
reactant: MODEL1310110025#
is described by: ECO:0000134
kinetic law: MODEL1310110025#
reversible: true
name: transport of ubiquinol into cytosol
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
is: SBO:0000185
product: MODEL1310110025#

metaM HC02205 e
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
boundary condition: false
name: prostaglandin-b2
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:28099

metaR PGDI
is version of: http://identifiers.org/ec-code/2.5.1.18
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
type: Reaction
product: MODEL1310110025#
reactant: MODEL1310110025#
name: Prostaglandin-H2 D-isomerase [Precursor]
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110025#
fast: false
is version of: http://identifiers.org/ec-code/5.3.99.2
kinetic law: MODEL1310110025#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110025#_fda3533d_8434_4809_a674_963600f1573c
initial amount: NaN
initial concentration: NaN
constant: false
is: Q1EHB4
boundary condition: true
is: SBO:0000252
is encoded by: hsa:159963
name: SLC5A12
type: Species
has only substance units: false

metaR MMEm
is version of: http://identifiers.org/ec-code/5.1.99.1
name: methylmalonyl-CoA epimerase/racemase
is described by: ECO:0000269
reactant: MODEL1310110025#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110025#
product: MODEL1310110025#
type: Reaction
fast: false
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (84693.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.1.99.1 Confidence Level: 4 AUTHORS: PMID:11481338 NOTES:TDV

http://identifiers.org/biomodels.db/MODEL1310110025#_37f426a5_978a_46b3_952d_ed0681ee61ba
is: SBO:0000252
has only substance units: false
is encoded by: hsa:57835
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is: Q9BY07
name: SLC4A5

http://identifiers.org/biomodels.db/MODEL1310110025#_5a55ba2e_77fb_4568_8549_7708be49f62b
is: Q86XP1
boundary condition: true
is encoded by: hsa:160851
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: DGKH
constant: false
is: SBO:0000252

metaR RE1526M
kinetic law: MODEL1310110025#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/4.2.1.107
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
fast: false
name: RE1526
modifier: MODEL1310110025#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_71a83835_6414_45d4_a439_a2d8cb71b3cf
is encoded by: hsa:51166
initial concentration: NaN
is: Q4W5N8
is: SBO:0000252
name: AADAT
initial amount: NaN
has only substance units: false
constant: false
type: Species
boundary condition: true

metaR RE2659R
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
reactant: MODEL1310110025#
product: MODEL1310110025#
reversible: true
is: SBO:0000176
fast: false
name: RE2659
is described by: ECO:0000000
type: Reaction

metaM 2hb c
has only substance units: false
constant: false
is: HMDB00008
type: Species
name: 2-Hydroxybutyrate
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:1148
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
is: SBO:0000247

metaR CLPNDCOAtx
kinetic law: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
fast: false
name: fatty acid intracellular transport
product: MODEL1310110025#
is: SBO:0000185
reactant: MODEL1310110025#
reversible: true
is described by: ECO:0000000

metaR r1019
product: MODEL1310110025#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110025#
is described by: ECO:0000000
type: Reaction
name: Postulated transport reaction
fast: false
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:

metaR r0845
product: MODEL1310110025#
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
name: Drug/Metabolite Transporter (DMT) TCDB:2.A.7.12.7
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12759756,PMID:17466261,PMID:9759482 NOTES:UGLCNACtg but different compartment
reversible: false
is described by: ECO:0000000

metaR ECOAH1m
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
is version of: http://identifiers.org/ec-code/4.2.1.18
product: MODEL1310110025#
type: Reaction
is described by: ECO:0000304
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
reactant: MODEL1310110025#
is: SBO:0000176
kinetic law: MODEL1310110025#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16

http://identifiers.org/biomodels.db/MODEL1310110025#_002a3b43_536f_49e7_8bdf_2ab6e3b04a03
constant: false
is: Q86SK9
has only substance units: false
is encoded by: hsa:79966
initial concentration: NaN
name: SCD5
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252

metaR NTD10
product: MODEL1310110025#
fast: false
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.5
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:15699053 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31. Rat
name: 5'-nucleotidase (XMP)
type: Reaction
modifier: MODEL1310110025#
is described by: ECO:0000254

metaR r0630
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110025#
fast: false
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
is version of: http://identifiers.org/ec-code/3.1.3.2
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.1
kinetic law: MODEL1310110025#
product: MODEL1310110025#
modifier: MODEL1310110025#
reversible: true

metaR r2141
kinetic law: MODEL1310110025#
type: Reaction
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000000
reversible: true
is: SBO:0000185

metaM ser L e
is: SBO:0000247
initial concentration: 1.0
is: HMDB00187
constant: false
has only substance units: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
name: L-serine
initial amount: NaN
type: Species
is: CHEBI:17115
boundary condition: false

metaM HC02175 c
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
name: caprate
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
type: Species
is: CHEBI:27689

metaM CE4792 m
constant: false
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-22,24,28-30,34,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4792
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:12947
name: 3-oxo-cis-8-tetradecenoyl-CoA
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_a26fd96a_7179_40b4_9953_ae1fbf7635ee
has only substance units: false
is encoded by: hsa:1962
initial concentration: NaN
is: SBO:0000252
type: Species
name: EHHADH
is: Q9NY65
boundary condition: true
initial amount: NaN
constant: false

metaR CAATPS
kinetic law: MODEL1310110025#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.3.8
product: MODEL1310110025#
name: Ca ATPase
notes: GENE_ASSOCIATION: (492.1) or (491.1) or (490.1) or (493.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.6 Confidence Level: 4 AUTHORS: PMID:7876199,PMID:8396145 NOTES:plasma membrane version (SR and ER versions also exist) stoichiometry actually varies (number of Ca/ATP transported). See PMID: 7876199 NJ
reactant: MODEL1310110025#
is: SBO:0000185
fast: false
type: Reaction
reversible: false
modifier: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_eaff4e2a_b2b4_40df_907f_4f8f27d4fad6
is: SBO:0000252
name: RRM2
type: Species
is encoded by: hsa:6241
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
is: P31350

metaR SQLEr
reversible: false
reactant: MODEL1310110025#
modifier: MODEL1310110025#
is: SBO:0000176
product: MODEL1310110025#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (6713.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.99.7 Confidence Level: 4 AUTHORS: PMID:1964954 NOTES:NCD
fast: false
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.14.13.132
type: Reaction
name: Squalene epoxidase, endoplasmic reticular (NADP)

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

metaR PMEVKc
is version of: http://identifiers.org/ec-code/2.7.4.2
reversible: false
notes: GENE_ASSOCIATION: (10654.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added to substrate for elemental balancing.
is: SBO:0000176
type: Reaction
name: phosphomevalonate kinase, cytosol
reactant: MODEL1310110025#
is described by: ECO:0000134
kinetic law: MODEL1310110025#
fast: false
modifier: MODEL1310110025#
product: MODEL1310110025#

metaR C14STRr
reactant: MODEL1310110025#
product: MODEL1310110025#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
is version of: http://identifiers.org/ec-code/1.3.1.70
is: SBO:0000176
is described by: ECO:0000134
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
fast: false
name: C-14 sterol reductase

http://identifiers.org/biomodels.db/MODEL1310110025#_614a4315_f5b5_4ddb_9e6d_eb95fabe971e
is: Q9NUD9
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:55650
initial amount: NaN
name: PIGV
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_5d8a7d32_ba5f_4a2e_b159_16648d69ad72
boundary condition: true
initial amount: NaN
is encoded by: hsa:56954
constant: false
name: NIT2
has only substance units: false
is: Q9NQR4
initial concentration: NaN
is: SBO:0000252
type: Species

metaR MMMm
is described by: ECO:0000269
reversible: true
is: SBO:0000176
name: methylmalonyl-CoA mutase
type: Reaction
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (4594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES:TDV
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
fast: false
is version of: http://identifiers.org/ec-code/5.4.99.2
product: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_2702de01_b400_40c7_a65d_262b11453ae8
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
is: Q9NR45
name: NANS
is encoded by: hsa:54187
initial amount: NaN

metaR r2140
kinetic law: MODEL1310110025#
is: SBO:0000185
fast: false
reversible: true
product: MODEL1310110025#
is described by: ECO:0000000
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110025#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaR S2TASE3ly
is version of: http://identifiers.org/ec-code/3.1.6.13
reactant: MODEL1310110025#
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (3423.2) or (3423.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110025#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110025#
is: SBO:0000176
reversible: false
fast: false
name: iduronate-2-sulfatase, lysosomal

metaR RE1531M
reversible: true
name: RE1531
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
reactant: MODEL1310110025#
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
type: Reaction

metaM HC00319 c
has only substance units: false
name: Malonate
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:30794
is: SBO:0000247
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
constant: false

metaR DGK1
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
name: deoxyguanylate kinase (dGMP:ATP)
kinetic law: MODEL1310110025#
product: MODEL1310110025#
is: SBO:0000176
reactant: MODEL1310110025#
fast: false
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.7.4.8

metaR r0932
reversible: true
product: MODEL1310110025#
kinetic law: MODEL1310110025#
name: Transport reaction
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000

metaR TCYNTt
is: SBO:0000185
is described by: ECO:0000000
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
type: Reaction
name: Thiocyanate transport via diffusion (cytosol to extracellular)
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
product: MODEL1310110025#

metaM HC02205 c
is: CHEBI:28099
boundary condition: false
name: prostaglandin-b2
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
constant: false

metaM ump r
name: UMP
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: HMDB00288
initial concentration: 1.0
is: CHEBI:57865
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false

metaM s7p c
is: HMDB01068
boundary condition: false
is: CHEBI:57483
initial amount: NaN
name: Sedoheptulose 7-phosphate
is: SBO:0000247
is: C05382
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382

metaR PNP
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000269
reactant: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: NAD metabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14704851,PMID:9030766 NOTES:IT
is: SBO:0000176
reversible: true
name: purine-nucleoside phosphorylase
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.1

metaR GLYt7 211 r
is described by: ECO:0000269
fast: false
modifier: MODEL1310110025#
is: SBO:0000185
name: glycine reversible transport via sodium and chloride symport (2:1:1)
product: MODEL1310110025#
kinetic law: MODEL1310110025#
type: Reaction
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reversible: true

metaR ABTti
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110025#
name: L-arabinitol transport via passive diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
is: SBO:0000185
reversible: false
product: MODEL1310110025#
reactant: MODEL1310110025#

metaR EX 3mlda LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-Methylimidazoleacetic acid exchange
type: Reaction

metaM 6pgl r
notes: FORMULA: C6H9O9P CHARGE: -2 INCHI: InChI=1S/C6H11O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-5,7-9H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00733 EHMN_ABBREVIATION: C01236
is: SBO:0000247
is: CHEBI:57955
initial concentration: 1.0
type: Species
initial amount: NaN
name: 6-O-phosphonato-D-glucono-1,5-lactone(2-)
has only substance units: false
constant: false
boundary condition: false
is: HMDB01127

metaM acgal l
type: Species
is: CHEBI:28037
initial concentration: 1.0
is: HMDB00212
boundary condition: false
name: N-acetyl-D-galactosamine
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110025#_327a60d3_37dd_4102_b7fe_fb9631ffc5b4
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
is: P13686
name: ACP5
has only substance units: false
is encoded by: hsa:54
initial amount: NaN
boundary condition: true

metaR PROSTGE2t2
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
reversible: true
product: MODEL1310110025#
modifier: MODEL1310110025#
is described by: ECO:0000269
fast: false
name: prostaglandin uniport

metaM leuktrA4 c
type: Species
name: leukotriene A4(1-)
initial amount: NaN
is: HMDB01337
boundary condition: false
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
is: CHEBI:57463
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaR RE3628M
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/5.3.3.8
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
reversible: true
kinetic law: MODEL1310110025#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
modifier: MODEL1310110025#
fast: false
product: MODEL1310110025#
name: RE3628

metaR r0853
kinetic law: MODEL1310110025#
name: Facilitated diffusion
is described by: ECO:0000000
reactant: MODEL1310110025#
is: SBO:0000185
fast: false
product: MODEL1310110025#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8132483 NOTES:

metaR ACETONEt2
kinetic law: MODEL1310110025#
fast: false
reactant: MODEL1310110025#
reversible: true
modifier: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
type: Reaction
is described by: ECO:0000269
name: acetone transport via proton symport
is: SBO:0000185

metaM Rtotal2 e
is: HMDB00244
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:3554
constant: false
initial amount: NaN
type: Species
name: R total 2 position
notes: FORMULA: CO2FULLR2 CHARGE: -1
is: C00255
has only substance units: false
boundary condition: false

metaR r2507
name: Utilized transport
fast: false
is: SBO:0000185
product: MODEL1310110025#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:

metaM dolmanp L r
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:15809
has only substance units: false
name: Dolichyl phosphate D-mannose, human liver homolog
initial concentration: 1.0
type: Species

metaR FAOXC140
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110025#
is described by: ECO:0000269
reversible: false
is: SBO:0000176
reactant: MODEL1310110025#
name: Beta oxidation of long chain fatty acid
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
product: MODEL1310110025#
fast: false

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

metaM damp c
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB00905
type: Species
initial amount: NaN
is: CHEBI:58245
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
name: dAMP(2-)

http://identifiers.org/biomodels.db/MODEL1310110025#_65d5c265_d00e_4994_8b5e_f4ec526b1f24
initial concentration: NaN
name: PDHX
initial amount: NaN
is encoded by: hsa:8050
constant: false
is: O00330
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110025#_9d56197c_80e2_4e3d_9a59_080f8a052f71
has only substance units: false
name: MOXD1
is: SBO:0000252
is encoded by: hsa:26002
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: Q6UVY6
constant: false

metaM prostgf2 c
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:57404
is: HMDB01139
name: prostaglandin F2alpha(1-)
is: SBO:0000247

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

metaM gly e
is: HMDB00123
is: C00037
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C2H5NO2 CHARGE: 0
boundary condition: false
is: CHEBI:3339
is: SBO:0000247
name: Glycine

metaR RE1709N
name: RE1709
modifier: MODEL1310110025#
type: Reaction
is: SBO:0000176
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.96
kinetic law: MODEL1310110025#
is described by: ECO:0000000
reactant: MODEL1310110025#
fast: false

metaM clpndcoa c
initial amount: NaN
is: HMDB06267
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
name: clupanodonyl CoA
is: http://identifiers.org/pubchem.compound/47205476
boundary condition: false
is: C16166
has only substance units: false
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR r1671
reactant: MODEL1310110025#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110025#
is: SBO:0000185
name: Y+LAT2 Utilized transport
type: Reaction
product: MODEL1310110025#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110025#

metaR BILGLCURtr
name: glucuronidated compound transport
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
product: MODEL1310110025#
reversible: true
reactant: MODEL1310110025#
type: Reaction
fast: false
kinetic law: MODEL1310110025#

metaM CE5118 m
is: SBO:0000247
name: trans-2-cis,cis-4,8-tetradecatrienoyl-CoA
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,12-15,22-24,28-30,34,45-46H,4-7,10-11,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,13-12-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5118
initial amount: NaN
initial concentration: 1.0
is: CHEBI:12947
has only substance units: false
type: Species
constant: false
boundary condition: false

metaR r2506
reactant: MODEL1310110025#
fast: false
name: Utilized transport
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110025#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
product: MODEL1310110025#

metaR UAGALDP
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110025#
fast: false
name: UDP-N-acetylgalactosamine diphosphorylase
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
reversible: false
reactant: MODEL1310110025#

metaR RE0830C
name: RE0830
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110025#
reversible: true
reactant: MODEL1310110025#
fast: false
product: MODEL1310110025#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110025#_cb1a15d6_8824_4839_994d_97bd055cb4ba
boundary condition: true
type: Species
name: NDUFV1
initial amount: NaN
is: E5KNH5
is: SBO:0000252
is encoded by: hsa:4723
initial concentration: NaN
has only substance units: false
constant: false

metaR FAOXC161802m
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
product: MODEL1310110025#
modifier: MODEL1310110025#
name: Beta oxidation fatty acid
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110025#
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.3.99.3

metaR LYSOXp
reversible: false
product: MODEL1310110025#
reactant: MODEL1310110025#
fast: false
name: L-lysine oxidase, peroxisomal
kinetic law: MODEL1310110025#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.4.3.14 Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957,PMID:6811962 NOTES:MM

metaM dolmanp U r
is: SBO:0000247
type: Species
is: CHEBI:15809
has only substance units: false
constant: false
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
name: Dolichyl phosphate D-mannose, human uterine homolog
initial amount: NaN
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110025#_73565f2c_4dd9_4eaa_a96a_2f668ae15876
has part: P08195
has only substance units: false
initial amount: NaN
has part: Q9NS82
name: SLC7A10:SLC3A2
boundary condition: true
constant: false
is encoded by: hsa:56301
is encoded by: hsa:6520
type: Species
initial concentration: NaN
is: SBO:0000297

metaM h2o l
is: SBO:0000247
name: water
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:15377
is: HMDB02111
initial concentration: 1.0
has only substance units: false
type: Species

metaM acgam6p c
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB01062
is: CHEBI:57513
constant: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
is: SBO:0000247
name: N-acetyl-D-glucosamine 6-phosphate(2-)
has only substance units: false
type: Species

metaR PTRCOX1
notes: GENE_ASSOCIATION: (26.1) or (314.1) or (8639.1) or (314.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:9119395 NOTES:SAB
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.4.3.21
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.4.3.22
reactant: MODEL1310110025#
reversible: false
is described by: ECO:0000304
name: Putrescine:oxygen oxidoreductase (deaminating)
product: MODEL1310110025#

metaM 4abut n
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
is: HMDB00112
notes: FORMULA: C4H9NO2 CHARGE: 0
initial amount: NaN
name: 4-Aminobutanoate
is: C00334

metaR r1806
reversible: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110025#
reactant: MODEL1310110025#
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000

metaM chsterol c
is: CHEBI:16113
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
constant: false
is: HMDB00067
boundary condition: false
initial amount: NaN
name: cholesterol

metaM dhlam m
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
boundary condition: false
is: HMDB00985
constant: false
is: CHEBI:17694
is: SBO:0000247
initial amount: NaN
name: dihydrolipoamide
has only substance units: false
initial concentration: 1.0
type: Species

metaR r0629
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
is version of: http://identifiers.org/ec-code/3.1.4.1
is: SBO:0000176
fast: false
reactant: MODEL1310110025#
product: MODEL1310110025#
type: Reaction
modifier: MODEL1310110025#
reversible: true
kinetic law: MODEL1310110025#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
is version of: http://identifiers.org/ec-code/3.6.1.22

http://identifiers.org/biomodels.db/MODEL1310110025#_c6447126_4bb3_4f7e_ae0c_7f2a205b6f31
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:H77542
initial concentration: NaN
boundary condition: true
name: _H77542_1_c

http://identifiers.org/biomodels.db/MODEL1310110025#_7e44b683_e4da_4da1_8b35_a362bc7bf1b6
name: ENTPD2
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:954
is: Q5SPY7
type: Species
is: SBO:0000252

metaR RE1525M
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE1525
modifier: MODEL1310110025#
is: SBO:0000176
product: MODEL1310110025#
is described by: ECO:0000000
reactant: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110025#

metaM hmgcoa m
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
is: HMDB01375
name: Hydroxymethylglutaryl-CoA
is: CHEBI:15467
type: Species
initial concentration: 1.0

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

metaM xoltetrol m
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol
is: HMDB01231
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:17278
boundary condition: false

metaM h2o m
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB02111
has only substance units: false
constant: false
is: CHEBI:15377
initial concentration: 1.0
is: C00001
initial amount: NaN
name: H2O
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001

http://identifiers.org/biomodels.db/MODEL1310110025#_d6f3e14c_b131_44a3_8399_392965ccd11f
type: Species
name: NDUFA4
boundary condition: true
is: O00483
is encoded by: hsa:4697
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_584533c7_a2bc_4669_ad74_a87d29014f8d
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:D29675
initial concentration: NaN
name: _D29675_1_c
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110025#_eeb4f57c_bbc1_4337_91c6_f3746efd2c5d
is: Q8TDB8
is: SBO:0000252
boundary condition: true
name: SLC2A14
initial amount: NaN
constant: false
type: Species
has only substance units: false
is encoded by: hsa:144195
initial concentration: NaN

metaM 4abut m
is: HMDB00112
has only substance units: false
initial concentration: 1.0
is: C00334
constant: false
initial amount: NaN
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
boundary condition: false
type: Species
is: CHEBI:16865
name: 4-Aminobutanoate
is: SBO:0000247

metaM leuktrA4 e
is: SBO:0000247
is: HMDB01337
is: CHEBI:57463
initial concentration: 1.0
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
initial amount: NaN
has only substance units: false
type: Species
name: leukotriene A4(1-)
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110025#_3210f540_003c_4e3a_a366_38a7e37560b9
name: ACADM
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:34
type: Species
is: SBO:0000252
is: P11310

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

metaR r2473
name: Major Facilitator(MFS) TCDB:2.A.1.4.5
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12811562 NOTES:
fast: false
product: MODEL1310110025#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110025#
is: SBO:0000185
reversible: false
reactant: MODEL1310110025#

metaR EX 10fthf7glu LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](7) exchange
type: Reaction

metaM 34hpp e
has only substance units: false
is: HMDB00707
initial concentration: 1.0
is: CHEBI:36242
boundary condition: false
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
name: 3-(4-hydroxyphenyl)pyruvate
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1

metaR BILDGLCURt
is: SBO:0000185
modifier: MODEL1310110025#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
product: MODEL1310110025#
kinetic law: MODEL1310110025#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110025#

metaM cholcoa c
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB01374
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
type: Species
has only substance units: false
name: choloyl-CoA(4-)
initial amount: NaN
is: CHEBI:57373
initial concentration: 1.0

metaR CYTD
is version of: http://identifiers.org/ec-code/3.5.4.5
type: Reaction
product: MODEL1310110025#
kinetic law: MODEL1310110025#
is described by: ECO:0000254
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (978.1) or (57379.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.5 Confidence Level: 2 AUTHORS: PMID:14744791,PMID:15087440,PMID:7923172,PMID:8001985,PMID:8422236 NOTES:
modifier: MODEL1310110025#
name: cytidine deaminase
reactant: MODEL1310110025#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110025#_f3c2d422_1a9d_4150_9e5e_4581d47d5c67
is encoded by: hsa:51
is: Q15067
name: ACOX1
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN

metaR r1018
product: MODEL1310110025#
fast: false
reversible: true
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
name: Transport reaction
kinetic law: MODEL1310110025#

metaM ppi x
name: Diphosphate
initial amount: NaN
is: CHEBI:33019
has only substance units: false
type: Species
is: C00013
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: HMDB00250

http://identifiers.org/biomodels.db/MODEL1310110025#_97414e34_a6c6_4b87_ae07_a0f2957f2ab7
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000297
name: EHHADH:ACAA1:ACOX1
is encoded by: hsa:1962
has part: Q9NY65
type: Species
boundary condition: true

metaM h2o n
has only substance units: false
constant: false
name: water
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial amount: NaN
boundary condition: false
is: HMDB02111
is: CHEBI:15377
type: Species
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110025#_1d001107_9dad_4256_b455_18111c793b2d
type: Species
initial amount: NaN
name: VNN3
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:55350
is: SBO:0000252
has only substance units: false

metaR r0202
reactant: MODEL1310110025#
is described by: ECO:0000000
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
fast: false
is: SBO:0000176
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
kinetic law: MODEL1310110025#
type: Reaction
reversible: true

metaR GLYtp
fast: false
type: Reaction
kinetic law: MODEL1310110025#
reversible: true
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:TDV
is described by: ECO:0000000
name: glycine passive transport to peroxisome
reactant: MODEL1310110025#
is: SBO:0000185

metaR HISTAtu
fast: false
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
reversible: true
type: Reaction
reactant: MODEL1310110025#
name: Histamine uniport
is: SBO:0000185
modifier: MODEL1310110025#
product: MODEL1310110025#
kinetic law: MODEL1310110025#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110025#_c6d8164e_0bcc_4fed_ad91_b07d5985c562
is: SBO:0000252
is: Q6NVC0
type: Species
name: SLC25A5
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:292

metaR r1743
name: Y+LAT2 Utilized transport
is: SBO:0000185
product: MODEL1310110025#
fast: false
type: Reaction
modifier: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110025#

metaR r1670
is: SBO:0000185
modifier: MODEL1310110025#
reversible: true
product: MODEL1310110025#
kinetic law: MODEL1310110025#
fast: false
name: Y+LAT2 Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110025#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110025#_becb1a7a_e2e4_4462_8a10_afb959031d14
has only substance units: false
initial amount: NaN
boundary condition: true
name: SRD5A1
is: P18405
initial concentration: NaN
is encoded by: hsa:6715
is: SBO:0000252
type: Species
constant: false

metaM chsterol e
name: cholesterol
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
type: Species
constant: false
is: CHEBI:16113
initial concentration: 1.0
initial amount: NaN
is: HMDB00067

metaR LEUTA
reactant: MODEL1310110025#
type: Reaction
kinetic law: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
is version of: http://identifiers.org/ec-code/2.6.1.42
name: leucine transaminase
modifier: MODEL1310110025#
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110025#_13d53e55_458f_40f2_b784_0b95c8a6a219
has only substance units: false
is encoded by: hsa:10050
type: Species
is: SBO:0000252
constant: false
name: SLC17A4
boundary condition: true
initial amount: NaN
is: Q9Y2C5
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_05b19bbe_66d4_4fea_bd96_12b1eedf4480
is: O95169
is encoded by: hsa:4714
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: NDUFB8
type: Species
initial amount: NaN

metaM eicostet e
has only substance units: false
notes: FORMULA: C20H31O2 CHARGE: -1
is: HMDB02177
is: CHEBI:36033
constant: false
name: eicosatetranoic acid
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaR PPD2CSPp
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reversible: false
reactant: MODEL1310110025#
fast: false
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:spontaneous cyclization reaction MM
name: PPD2CSPp
product: MODEL1310110025#

metaR r0627
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
product: MODEL1310110025#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
reactant: MODEL1310110025#
type: Reaction
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_7964bb95_2d5e_4778_a9d0_ab69d57b158a
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4698
constant: false
initial concentration: NaN
has only substance units: false
name: NDUFA5
boundary condition: true
is: Q16718
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_1535cd0d_9efb_4c4f_a3bb_ddb6f8b903ad
is: Q7Z364
is: SBO:0000252
has only substance units: false
name: PDE1B
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5153
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_95eac92b_22f8_4b47_819b_c1490446cedb
is: E9PB82
constant: false
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3295
initial concentration: NaN
name: HSD17B4

metaM dag hs r
is: CHEBI:18035
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
has only substance units: false
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
is: SBO:0000247
name: diglyceride

http://identifiers.org/biomodels.db/MODEL1310110025#_03ff7b12_9a35_4899_a648_972d446037d1
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:221823
name: PRPS1L1

metaM 34hpp c
initial concentration: 1.0
name: 3-(4-hydroxyphenyl)pyruvate
is: CHEBI:36242
is: SBO:0000247
is: HMDB00707
initial amount: NaN
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
type: Species
constant: false
has only substance units: false
boundary condition: false

metaR CLOHtex2
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
type: Reaction
kinetic law: MODEL1310110025#
is: SBO:0000185
name: chloride transport via hydroxide countertransport (2:1)
fast: false
reactant: MODEL1310110025#
reversible: false
product: MODEL1310110025#
modifier: MODEL1310110025#
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110025#_e3685e02_55b6_41bd_a575_0fdef6a7230b
is: P32929
has only substance units: false
is encoded by: hsa:1491
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
constant: false
name: CTH
is: SBO:0000252

metaR NCKt
reactant: MODEL1310110025#
modifier: MODEL1310110025#
is: SBO:0000185
name: Na+/Ca2+-K+ exchange
is described by: ECO:0000269
fast: false
reversible: true
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
product: MODEL1310110025#
kinetic law: MODEL1310110025#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_7e2c47d3_b26b_49cf_9eb4_f32fe7780b56
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:5279
initial concentration: NaN
name: PIGC
type: Species
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_bf18db4d_ff67_41df_b81c_47f930d80e93
name: GPX6
type: Species
is: P59796
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:257202
initial amount: NaN
initial concentration: NaN
constant: false

metaR RDH2a
notes: GENE_ASSOCIATION: (195814.1) or (112724.1) or (145226.1) or (51109.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12435598,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
reactant: MODEL1310110025#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.300
modifier: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.105
kinetic law: MODEL1310110025#
is: SBO:0000176
name: retinol dehydrogenase (9-cis,NADPH)
reversible: true

metaR RE2541E
is version of: http://identifiers.org/ec-code/3.2.1.31
is described by: ECO:0000000
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
reactant: MODEL1310110025#
type: Reaction
reversible: true
name: RE2541
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
fast: false
product: MODEL1310110025#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110025#_8fb79813_8596_4ded_9758_9d6be6c3b1d6
is: SBO:0000252
constant: false
boundary condition: true
name: CYBRD1
is encoded by: hsa:79901
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: B4DWD7

metaM HC00319 m
type: Species
constant: false
is: SBO:0000247
boundary condition: false
name: Malonate
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:30794
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)

metaR XYLtly
name: Xylose efflux from lysosome
kinetic law: MODEL1310110025#
product: MODEL1310110025#
is: SBO:0000185
reversible: false
fast: false
is described by: ECO:0000000
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
type: Reaction

metaM mlthf m
type: Species
is: HMDB01533
has only substance units: false
initial amount: NaN
name: 5,10-Methylenetetrahydrofolate
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:15636
is: C00143
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143

metaR SO4CLtex2
reversible: false
modifier: MODEL1310110025#
is described by: ECO:0000304
reactant: MODEL1310110025#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
name: sulfate transport via chloride countertransport (2:1)
type: Reaction

metaR CSPG Btly
is described by: ECO:0000000
name: chondroitin sulfate B transport, extracellular to lysosome
reactant: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
is: SBO:0000185
fast: false
reversible: false
kinetic law: MODEL1310110025#

metaM amet m
is: HMDB01185
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:15414
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
name: S-Adenosyl-L-methionine
is: C00019
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaM cl c
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:3966
name: Chloride
notes: FORMULA: Cl CHARGE: -1
is: C00115
type: Species
constant: false
initial amount: NaN
is: HMDB00492

metaR CYTK10n
fast: false
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110025#
type: Reaction
name: cytidylate kinase (CMP,dGTP),nuclear
reversible: true
product: MODEL1310110025#
is described by: ECO:0000269
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110025#_9e9cfeff_4ec9_408f_ae14_8e0ed60b4c2a
constant: false
is: O75438
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: NDUFB1
is encoded by: hsa:4707
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_b462fe9f_2440_4f55_8676_1da6967922fe
initial concentration: NaN
is: B2RA41
is encoded by: hsa:6554
initial amount: NaN
type: Species
name: SLC10A1
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

metaR PSSA1 hs
fast: false
is: SBO:0000176
reversible: true
name: Phosphatidylserine synthase homo sapiens
is version of: http://identifiers.org/ec-code/2.7.8.29
notes: GENE_ASSOCIATION: (9791.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylcholine as substrate NJ
product: MODEL1310110025#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110025#
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_f95e9423_792f_4f5a_95cf_f8e877df6c7c
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
is: O95528
boundary condition: true
name: SLC2A10
is encoded by: hsa:81031
initial amount: NaN
has only substance units: false

metaR r1894
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110025#
reversible: false
product: MODEL1310110025#
type: Reaction
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110025#
is: SBO:0000185
modifier: MODEL1310110025#
is described by: ECO:0000000

metaR GPAM hs
type: Reaction
notes: GENE_ASSOCIATION: (57678.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 2.3.1.15 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
modifier: MODEL1310110025#
name: glycerol-3-phosphate acyltransferase
is version of: http://identifiers.org/ec-code/2.3.1.15
reversible: false
product: MODEL1310110025#
is described by: ECO:0000000
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
fast: false

metaR r0033
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.5
modifier: MODEL1310110025#
reversible: false
kinetic law: MODEL1310110025#
is described by: ECO:0000000
reactant: MODEL1310110025#
is: SBO:0000176
fast: false
product: MODEL1310110025#

metaR ME2m
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.1.1.40
name: malic enzyme (NADP), mitochondrial
modifier: MODEL1310110025#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4200.1) or (10873.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:IF
is: SBO:0000176
product: MODEL1310110025#
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.1.1.38
type: Reaction
reversible: false

metaM C05965 e
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
constant: false
has only substance units: false
name: 12(S)-HPETE(1-)
is: CHEBI:57444
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
is: HMDB04243

http://identifiers.org/biomodels.db/MODEL1310110025#_cbb2b9d2_d6eb_421e_820e_0dfc61739282
type: Species
initial amount: NaN
name: BDH1
initial concentration: NaN
is encoded by: hsa:622
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110025#_dad074e7_18e1_4508_89fd_b5dc2abcd072
is encoded by: hsa:AW277253
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
constant: false
has only substance units: false
name: _AW277253_1_c
is: SBO:0000252

metaM mmcoa R m
is: HMDB01269
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:57326
name: (R)-methylmalonyl-CoA(5-)
boundary condition: false
constant: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721

metaR DHORTS
reactant: MODEL1310110025#
modifier: MODEL1310110025#
name: dihydroorotase
fast: false
reversible: true
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.1.3.2
product: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 3.5.2.3 Confidence Level: 4 AUTHORS: PMID:2565865,PMID:8619816 NOTES:
is described by: ECO:0000269
is: SBO:0000176

metaR DHFR
kinetic law: MODEL1310110025#
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.3
modifier: MODEL1310110025#
name: dihydrofolate reductase
is: SBO:0000176
fast: false
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
is described by: ECO:0000254
product: MODEL1310110025#
reversible: true

metaM CE2433 m
is: SBO:0000247
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/5041
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: C01936

http://identifiers.org/biomodels.db/MODEL1310110025#_6379f448_8309_47e8_8ed6_f34e07e09ab8
has only substance units: false
initial amount: NaN
constant: false
type: Species
boundary condition: true
initial concentration: NaN
name: PYCR1
is: A6NFM2
is: SBO:0000252
is encoded by: hsa:5831

metaM so3 c
is: SBO:0000247
is: C00094
is: HMDB00240
has only substance units: false
constant: false
is: CHEBI:17137
initial concentration: 1.0
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
name: Sulfite
initial amount: NaN
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110025#_7ac0cb4a_dbd4_4b62_9776_9fe8e2d550bc
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: E5KS60
constant: false
type: Species
is encoded by: hsa:8803
has only substance units: false
is: SBO:0000252
name: SUCLA2

metaR r1746
name: Y+LAT2 Utilized transport
reactant: MODEL1310110025#
type: Reaction
fast: false
modifier: MODEL1310110025#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110025#
is described by: ECO:0000000
product: MODEL1310110025#
reversible: false

metaR RE3003M
reactant: MODEL1310110025#
modifier: MODEL1310110025#
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/5.3.3.8
name: RE3003
type: Reaction
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
fast: false
kinetic law: MODEL1310110025#
is described by: ECO:0000000

metaM creat e
is: CHEBI:16919
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
constant: false
initial concentration: 1.0
has only substance units: false
name: creatine
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB00064

metaR NADtpu
is: SBO:0000185
name: NAD transporter, peroxisome
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into peroxisome (to avoid loops w/ NAD/NADP) NJ
product: MODEL1310110025#

metaM eicostet c
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: eicosatetranoic acid
is: CHEBI:36033
notes: FORMULA: C20H31O2 CHARGE: -1
is: HMDB02177
initial amount: NaN

metaM mem2emgacpail hs r
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:16038
is: SBO:0000247
notes: FORMULA: C59H110N3O40P3FULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
type: Species
name: ({[(mannosyl),(phosphoethanolaminyl)]-dimannosyl},{phosphoethanolaminyl})-mannosyl-glucosaminyl-acylphosphatidylinositol (M4B)
constant: false

metaR CITRtm
kinetic law: MODEL1310110025#
name: citrulline mitochondrial transport via proton antiport
type: Reaction
is: SBO:0000185
reactant: MODEL1310110025#
product: MODEL1310110025#
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
fast: false
is described by: ECO:0000269
reversible: true

metaM gly c
initial amount: NaN
is: C00037
is: SBO:0000247
is: CHEBI:3339
has only substance units: false
boundary condition: false
name: Glycine
notes: FORMULA: C2H5NO2 CHARGE: 0
initial concentration: 1.0
is: HMDB00123
type: Species
constant: false

metaM cl e
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:3966
has only substance units: false
is: C00115
constant: false
initial amount: NaN
type: Species
name: Chloride
is: HMDB00492
notes: FORMULA: Cl CHARGE: -1

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

metaR r2508
reactant: MODEL1310110025#
type: Reaction
name: Utilized transport
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:

metaR MALSO3tm
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110025#
name: Malate:sulfite antiport, mitochondrial
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reversible: true
modifier: MODEL1310110025#
product: MODEL1310110025#
reactant: MODEL1310110025#

metaM h2o r
is: HMDB02111
name: H2O
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
is: C00001
has only substance units: false
type: Species
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: CHEBI:15377
initial amount: NaN

metaM ile L m
initial amount: NaN
has only substance units: false
name: L-isoleucine
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:17191
is: HMDB00172
boundary condition: false
is: SBO:0000247

metaR PRPNCOAHYDm
reactant: MODEL1310110025#
is described by: ECO:0000134
type: Reaction
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
name: Propenoyl-CoA hydrolase (m)
is version of: http://identifiers.org/ec-code/4.2.1.18
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay
reversible: false
modifier: MODEL1310110025#
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_772c46d8_a3ef_4b3d_856f_4928b860b999
constant: false
has only substance units: false
initial concentration: NaN
is: E9PEI9
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4047
type: Species
initial amount: NaN
name: LSS

http://identifiers.org/biomodels.db/MODEL1310110025#_a77c6ab3_2c89_4465_a95e_8731cfe8167f
type: Species
initial concentration: NaN
initial amount: NaN
is: P17707
is: SBO:0000252
is encoded by: hsa:262
boundary condition: true
name: AMD1
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_a21ac851_793e_417f_ace5_a88217a10954
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:3158
boundary condition: true
is: P54868
name: HMGCS2

metaM so3 m
constant: false
is: HMDB00240
name: hydrogensulfite
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17137
type: Species
is: SBO:0000247
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
boundary condition: false

metaR RE1903R
reversible: true
name: RE1903
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:
type: Reaction
product: MODEL1310110025#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_2610e834_2d60_4ec8_b12f_e3f035679541
type: Species
is encoded by: hsa:H17063
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: _H17063_1_m
boundary condition: true
is: SBO:0000252

metaR CYTDt
name: cytidine facilated transport in cytosol
type: Reaction
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
reversible: true
modifier: MODEL1310110025#
reactant: MODEL1310110025#
product: MODEL1310110025#
is: SBO:0000185
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110025#_9307e19b_5f1d_4e0d_84fc_b2b3375d8798
initial concentration: NaN
boundary condition: true
is encoded by: hsa:224
is: P51648
name: ALDH3A2
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252

metaR GULN3D
reactant: MODEL1310110025#
name: L-gulonate 3-dehydrogenase
is: SBO:0000176
product: MODEL1310110025#
fast: false
reversible: true
kinetic law: MODEL1310110025#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_d88df389_cb84_4add_a7f6_5db594bd737a
constant: false
is encoded by: hsa:11254
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: Q9UN76
is: SBO:0000252
name: SLC6A14
has only substance units: false

metaR PNTOte
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110025#
product: MODEL1310110025#
kinetic law: MODEL1310110025#
name: Transport of (R)-Pantothenate

metaR NCAMUP
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069599,PMID:1463467 NOTES:SAB mechanism copied from nac--not certain
type: Reaction
product: MODEL1310110025#
reactant: MODEL1310110025#
name: Nicotinamide acid uptake
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110025#

metaM crm hs e
type: Species
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:52639
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
name: N-acylsphingosine
boundary condition: false

metaM creat c
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
constant: false
initial concentration: 1.0
is: HMDB00064
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:16919
name: creatine
boundary condition: false

metaM abt c
initial concentration: 1.0
name: L-arabinitol
is: CHEBI:18403
type: Species
is: HMDB01851
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
has only substance units: false
initial amount: NaN
constant: false

metaM fald e
is: SBO:0000247
name: formaldehyde
type: Species
initial concentration: 1.0
is: CHEBI:16842
has only substance units: false
is: HMDB01426
boundary condition: false
initial amount: NaN
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_8d43f9dd_adba_4d8d_a6bd_6bb9f127f885
is: SBO:0000252
is encoded by: hsa:80704
boundary condition: true
name: SLC19A3
has only substance units: false
is: Q9BZV2
initial concentration: NaN
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_186ffd2e_0e7f_41d2_9d19_06f69256e1d4
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
name: PDE7A
is encoded by: hsa:5150
boundary condition: true
is: Q13946
has only substance units: false

metaM gly m
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
name: Glycine
is: CHEBI:15428
boundary condition: false
constant: false
type: Species
has only substance units: false
is: C00037
is: HMDB00123

http://identifiers.org/biomodels.db/MODEL1310110025#_c7ac9442_72f8_4483_bfa1_aafe8a3d01e9
is encoded by: hsa:29085
name: PHPT1
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
is: Q9P019
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_ea421e59_977f_400a_998e_c9ad67f9c7ac
initial concentration: NaN
is encoded by: hsa:7389
has only substance units: false
name: UROD
is: P06132
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species

metaR r0142
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/3.6.1.5
reactant: MODEL1310110025#
reversible: false
fast: false
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
type: Reaction
modifier: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_ac5f5a56_e2e4_4962_82a3_d6aa73ad4c4b
type: Species
is encoded by: hsa:114134
has only substance units: false
is: Q96QE2
boundary condition: true
initial concentration: NaN
name: SLC2A13
constant: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_cacdeb04_ea92_4967_b506_a7c584a29a96
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:BE042354
type: Species
name: _BE042354_1_m
initial amount: NaN

metaR DGCHOLtx
type: Reaction
is described by: ECO:0000000
name: bile acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
product: MODEL1310110025#
reactant: MODEL1310110025#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110025#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110025#_2b8fc1ef_88d7_4f15_9eec_6327f09702ca
has only substance units: false
initial amount: NaN
type: Species
name: _AI222095_1_e
is encoded by: hsa:AI222095
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_276c1b75_f0c5_4d36_9197_49101ad67db8
has only substance units: false
constant: false
name: SDHA
type: Species
initial concentration: NaN
is: P31040
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:6389

metaR RE3567C
name: RE3567
kinetic law: MODEL1310110025#
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
product: MODEL1310110025#
is: SBO:0000176
is described by: ECO:0000000

metaR LEUKTRE4t
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: leukotriene E4 transport
product: MODEL1310110025#
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_c6dcd0b5_b2bb_44e5_be31_1461733d6aff
is: Q8WVQ1
has only substance units: false
name: CANT1
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:124583
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110025#_95a3ffb2_9596_4e2f_97fe_a467992f0243
is encoded by: hsa:7167
constant: false
is: Q53HE2
boundary condition: true
name: TPI1
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN

metaR r1975
fast: false
reversible: false
modifier: MODEL1310110025#
name: Y+LAT2 Utilized transport
type: Reaction
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110025#
product: MODEL1310110025#

metaM h2o c
is: C00001
boundary condition: false
initial concentration: 1.0
is: HMDB02111
notes: FORMULA: H2O CHARGE: 0
constant: false
is: SBO:0000247
is: CHEBI:3303
type: Species
has only substance units: false
initial amount: NaN
name: H2O

metaR DM Ser Gly Ala X Gly ly
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser-Gly/Ala-X-Gly(ly)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_0bef6183_1b8f_4db3_a4f3_b9fab41bdb3d
initial concentration: NaN
constant: false
is encoded by: hsa:1375
boundary condition: true
has only substance units: false
name: CPT1B
type: Species
is: Q53FV7
is: SBO:0000252
initial amount: NaN

metaM adrncoa x
is: http://identifiers.org/pubchem.compound/47205480
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
name: adrenyl coenzyme A
is: C16170
type: Species
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
is: SBO:0000247

metaM crm hs c
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:52639
initial amount: NaN
has only substance units: false
type: Species
name: N-acylsphingosine
constant: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195

http://identifiers.org/biomodels.db/MODEL1310110025#_bbc093a2_faa7_4e89_9a02_3285f173fdca
is encoded by: hsa:3283
is: SBO:0000252
constant: false
name: HSD3B1
has only substance units: false
initial amount: NaN
is: P14060
type: Species
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_4dcf2f61_9225_4d05_8b5c_c4855b813657
initial concentration: NaN
is: SBO:0000252
constant: false
name: PPT2
is: Q9UMR5
is encoded by: hsa:9374
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_8eb774d5_4a3a_4cab_bc80_10f560725827
is: SBO:0000252
name: AGPAT5
constant: false
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:55326
is: Q9NUQ2

metaM fald c
initial concentration: 1.0
is: HMDB01426
name: formaldehyde
has only substance units: false
constant: false
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:16842
boundary condition: false

metaM pheme c
initial amount: NaN
type: Species
boundary condition: false
name: Protoheme
constant: false
initial concentration: 1.0
has only substance units: false
is: C00032
is: CHEBI:17627
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
is: SBO:0000247
is: HMDB03178

metaR LNLCCPT1
reactant: MODEL1310110025#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110025#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110025#
name: carnitine O-palmitoyltransferase
reversible: false
is: SBO:0000176
fast: false
kinetic law: MODEL1310110025#

metaM hestratriol r
type: Species
initial amount: NaN
is: HMDB05896
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
name: 4,17 dihydroxy estradiol
boundary condition: false

metaR HIStN1
modifier: MODEL1310110025#
type: Reaction
fast: false
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
reversible: true
is: SBO:0000185
name: Histidine transport (Na, H coupled)
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110025#_ccdcd495_ad6f_4a87_9bb6_857c46305f77
initial concentration: NaN
is encoded by: hsa:7108
is: O76062
has only substance units: false
name: TM7SF2
type: Species
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_fadd35bb_5520_4ae7_bfe4_6a43293c81b0
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: DGKB
boundary condition: true
constant: false
is encoded by: hsa:1607

metaR RE1709C
type: Reaction
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
is: SBO:0000176
product: MODEL1310110025#
fast: false
name: RE1709
reactant: MODEL1310110025#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110025#_096d5faa_3301_4312_8601_a6d2d5fd603d
type: Species
is encoded by: hsa:50940
is: Q9HCR9
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
name: PDE11A
is: SBO:0000252

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaR EX cspg a LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan exchange
type: Reaction

metaR DCYTt
reversible: true
kinetic law: MODEL1310110025#
type: Reaction
reactant: MODEL1310110025#
name: deoxycytidine transport via diffusion
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110025#_ea3c2199_2ca5_450d_aad9_687735a08a85
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:D87002
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
name: _D87002_1_e

metaR PAIL HStn
type: Reaction
name: phosphatidylinositol nuclear transport (diffusion)
reactant: MODEL1310110025#
reversible: true
kinetic law: MODEL1310110025#
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:

metaR r1400
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
is: SBO:0000185
reversible: false
product: MODEL1310110025#
reactant: MODEL1310110025#
name: Active transport
type: Reaction
fast: false
kinetic law: MODEL1310110025#
is described by: ECO:0000000

metaR NADPHtru
is described by: ECO:0000000
kinetic law: MODEL1310110025#
reversible: false
reactant: MODEL1310110025#
product: MODEL1310110025#
name: NADPH transporter, endoplasmic reticulum
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ

metaR r1010
type: Reaction
kinetic law: MODEL1310110025#
reversible: true
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
fast: false
name: Postulated transport reaction
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110025#

metaR r0517
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
is version of: http://identifiers.org/ec-code/1.17.4.1
product: MODEL1310110025#
fast: false
reactant: MODEL1310110025#
is: SBO:0000176
reversible: true
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
type: Reaction
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
is described by: ECO:0000000

metaR LNLCCPT2
is: SBO:0000176
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110025#
reversible: false
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
name: carnitine transferase

metaR CYSSNAT5tc
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaM h2o e
is: HMDB02111
has only substance units: false
boundary condition: false
name: H2O
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:15377
initial amount: NaN
type: Species
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: C00001

metaR EX cytd LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Cytidine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_767d6cb9_2485_45f6_b1c6_afbd291d50e8
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: P30838
is encoded by: hsa:218
constant: false
name: ALDH3A1
type: Species
has only substance units: false
boundary condition: true

metaR CYTK6n
is described by: ECO:0000269
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (CMP,CTP),nuclear
reversible: true
modifier: MODEL1310110025#
is: SBO:0000176
reactant: MODEL1310110025#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
kinetic law: MODEL1310110025#

metaR r2381
fast: false
is: SBO:0000185
type: Reaction
reversible: false
product: MODEL1310110025#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110025#
is described by: ECO:0000000
kinetic law: MODEL1310110025#

metaR GPIMTer L
modifier: MODEL1310110025#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (93183.1) and (54965.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11226175,PMID:15635094 NOTES:NCD
name: GlcN-acylPI mannosyltransferase, endoplasmic reticulum
product: MODEL1310110025#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110025#
fast: false

metaM andrstandn r
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
is: CHEBI:15994
initial amount: NaN
is: SBO:0000247
name: 5alpha-androstane-3,17-dione
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
is: HMDB00899
boundary condition: false

metaR DNDPt10m
name: dADP transport via dCDP antiport
is: SBO:0000185
type: Reaction
reversible: false
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_d00a715d_e8d8_4766_982d_aa55a11971b0
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
name: GGT2
is encoded by: hsa:728441
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_23ee0a96_4bd8_49c1_86ac_a1040b82d68c
type: Species
constant: false
is: SBO:0000252
boundary condition: true
name: _AI601100_1_m
is encoded by: hsa:AI601100
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR O2Stm
is described by: ECO:0000000
reactant: MODEL1310110025#
type: Reaction
name: superoxide anion transport via diffusion (mitochondria)
product: MODEL1310110025#
is: SBO:0000185
reversible: true
fast: false
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:

metaR RE1518M
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
type: Reaction
fast: false
product: MODEL1310110025#
is: SBO:0000176
reactant: MODEL1310110025#
reversible: true
modifier: MODEL1310110025#
name: RE1518
is version of: http://identifiers.org/ec-code/1.3.99.13
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000000

metaM pheme e
type: Species
initial amount: NaN
constant: false
is: C00032
is: CHEBI:17627
name: Protoheme
boundary condition: false
is: HMDB03178
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032

metaM acrn c
is: CHEBI:57589
has only substance units: false
is: HMDB00201
name: O-acetylcarnitine
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
type: Species
is: SBO:0000247

metaM 3mop m
name: 3-methyl-2-oxopentanoate
constant: false
type: Species
is: CHEBI:28654
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB00491
is: SBO:0000247
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
initial amount: NaN

metaR CYTDtm
product: MODEL1310110025#
name: cytidine facilated transport in mitochondria
is described by: ECO:0000269
reactant: MODEL1310110025#
reversible: true
type: Reaction
is: SBO:0000185
modifier: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
kinetic law: MODEL1310110025#

metaR r2042
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110025#
modifier: MODEL1310110025#
reversible: false
type: Reaction
kinetic law: MODEL1310110025#
product: MODEL1310110025#
is: SBO:0000185
is described by: ECO:0000000
fast: false

metaR EX estradiol LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: estradiol exchange
type: Reaction

metaR r2380
type: Reaction
reversible: true
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
product: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false
kinetic law: MODEL1310110025#

metaM but m
is: HMDB00039
constant: false
type: Species
name: butyrate
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
has only substance units: false
boundary condition: false
is: CHEBI:17968

metaM cmpacna c
is: CHEBI:57812
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: HMDB01176
is: SBO:0000247
name: CMP-N-acetyl-beta-neuraminate(2-)

http://identifiers.org/biomodels.db/MODEL1310110025#_a04e3ac6_67a6_44fe_b61d_6fa0e94db013
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:9962
initial concentration: NaN
type: Species
constant: false
name: SLC23A2

http://identifiers.org/biomodels.db/MODEL1310110025#_46173447_6679_4a28_93d8_ffe06ca0d6cd
is: SBO:0000297
constant: false
type: Species
initial concentration: NaN
has part: P82251
initial amount: NaN
is encoded by: hsa:11136
is encoded by: hsa:6519
name: SLC7A9:SLC3A1
has part: Q07837
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110025#_aa0694c0_8cce_44d0_852e_35f36e3924b2
is: Q7LG56
is: SBO:0000252
is encoded by: hsa:50484
initial amount: NaN
name: RRM2B
constant: false
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true

metaR r1741
modifier: MODEL1310110025#
name: Y+LAT2 Utilized transport
reversible: false
type: Reaction
fast: false
reactant: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000000
kinetic law: MODEL1310110025#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM HC02180 c
constant: false
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:28728
name: thromboxane-b2

metaR DHCR72r
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
product: MODEL1310110025#
name: 7-dehydrocholesterol reductase
is version of: http://identifiers.org/ec-code/1.3.1.21
modifier: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ

metaR EX uri LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Uridine
type: Reaction

metaR RE3520E
name: RE3520
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
is version of: http://identifiers.org/ec-code/1.11.1.9
modifier: MODEL1310110025#
is described by: ECO:0000000
reactant: MODEL1310110025#
is: SBO:0000176
product: MODEL1310110025#
reversible: true
kinetic law: MODEL1310110025#
fast: false
type: Reaction

metaR r0208
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
is: SBO:0000176
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13
type: Reaction
fast: false
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/4.4.1.1
reactant: MODEL1310110025#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110025#_3b837ba4_6eba_490e_8d3d_90042017620d
name: DGUOK
type: Species
is: SBO:0000252
is encoded by: hsa:1716
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false

metaR BILIRED
is described by: ECO:0000000
fast: false
name: Nad(p)h biliverdin reductase
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (645.1) or (644.1) SUBSYSTEM: Heme degradation EC Number: 1.3.1.24 Confidence Level: 0 AUTHORS: PMID:12456881,PMID:7656592,PMID:8117274 NOTES:TDV
modifier: MODEL1310110025#
is: SBO:0000176
product: MODEL1310110025#
reversible: false
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.3.1.24
type: Reaction

metaR RE1233C
is described by: ECO:0000000
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.6.1.64
kinetic law: MODEL1310110025#
name: RE1233
is: SBO:0000176
modifier: MODEL1310110025#
type: Reaction
reversible: true
fast: false
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side

metaM HC02208 c
type: Species
is: CHEBI:27696
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
name: prostaglandin-d1
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_2102226d_560f_40d9_83bc_54983a7668ca
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
boundary condition: true
name: NDUFA10
is: SBO:0000252
is: O95299
has only substance units: false
is encoded by: hsa:4705

metaR PPCOAOm
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110025#
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000269
name: Propanoyl-CoA:FAD 2,3-oxidoreductase, mitochondrial
notes: GENE_ASSOCIATION: (80724.1) or (27034.1) or (36.1) or (35.1) or (84129.1) or (34.1) or (28976.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:12359132,PMID:12359260,PMID:15560374,PMID:2565344,PMID:3035565,PMID:7698750,PMID:8276399 NOTES:NCD
reactant: MODEL1310110025#
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
product: MODEL1310110025#

metaM dcholcoa c
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB06292
is: CHEBI:28701
initial concentration: 1.0
name: chenodeoxycholoyl coenzyme a
constant: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_d153a2d8_6767_4754_b14e_303d479bfbc4
name: ALDH7A1
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:501
is: SBO:0000252
constant: false
is: E7EPT3

metaR H7 TAer
reversible: false
type: Reaction
fast: false
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10727241,PMID:11483512,PMID:12802054,PMID:15632136,PMID:9356492,PMID:9468317 NOTES:EC 2.6.-.- NCD
reactant: MODEL1310110025#
name: H7' transamidase, endoplasmic reticulum
is described by: ECO:0000000
kinetic law: MODEL1310110025#
is: SBO:0000176

metaR PMANM
type: Reaction
product: MODEL1310110025#
fast: false
is version of: http://identifiers.org/ec-code/5.4.2.8
reversible: true
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110025#
is: SBO:0000176
name: phosphomannomutase
is version of: http://identifiers.org/ec-code/5.4.2.2
modifier: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_43fea839_f521_4c2e_89fd_262591c5c26f
boundary condition: true
name: _NOS2A_1_c
initial concentration: NaN
has only substance units: false
type: Species
constant: false
is encoded by: hsa:NOS2A
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110025#_d1929904_36e3_4208_9d0a_3043c6b3c9ed
initial concentration: NaN
is: P30838
constant: false
type: Species
is encoded by: hsa:218
name: ALDH3A1
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR GLYtm
reactant: MODEL1310110025#
is: SBO:0000185
reversible: true
name: glycine passive transport to mitochondria
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
product: MODEL1310110025#
kinetic law: MODEL1310110025#
fast: false
type: Reaction

metaR r0145
fast: false
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.8.3.1
is described by: ECO:0000000
modifier: MODEL1310110025#
reversible: true
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
is: SBO:0000176
product: MODEL1310110025#
reactant: MODEL1310110025#
type: Reaction
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39

http://identifiers.org/biomodels.db/MODEL1310110025#_63c0cc91_9dfc_44a0_bca6_51c33f089e5d
name: ACSL3
is: SBO:0000252
constant: false
is: O95573
type: Species
initial concentration: NaN
is encoded by: hsa:2181
has only substance units: false
initial amount: NaN
boundary condition: true

metaR HESTRATRIOLtr
fast: false
name: hydroxylated estrogen derivative transport
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism, hydroxylated (inactivated) estrogen derivative needs to be transported out of the cell NJ
product: MODEL1310110025#
type: Reaction
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
reversible: true

metaM prostgf2 e
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
name: prostaglandin F2alpha(1-)
is: CHEBI:57404
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
initial amount: NaN
is: HMDB01139

metaM HC01401 m
initial amount: NaN
is: CHEBI:27668
constant: false
initial concentration: 1.0
name: (S)-3-Hydroxydodecanoyl-CoA
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
has only substance units: false

metaM Rtotal2 c
notes: FORMULA: CO2FULLR2 CHARGE: -1
is: CHEBI:60377
is: SBO:0000247
type: Species
has only substance units: false
name: R total 2 position
is: C00055
initial amount: NaN
boundary condition: false
is: HMDB00095
constant: false
initial concentration: 1.0

metaR RE0830N
type: Reaction
is: SBO:0000176
modifier: MODEL1310110025#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.96
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
reversible: true
product: MODEL1310110025#
is described by: ECO:0000000
kinetic law: MODEL1310110025#
name: RE0830
reactant: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_1b404331_bc02_403a_b01a_68e007f2530e
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:219
has only substance units: false
constant: false
initial concentration: NaN
name: ALDH1B1
boundary condition: true
type: Species
is: P30837

metaR GLYSNAT5tc
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR ACOAD8m
fast: false
type: Reaction
reactant: MODEL1310110025#
name: acyl-CoA dehydrogenase (isovaleryl-CoA), mitochondrial
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.3.99.10
notes: GENE_ASSOCIATION: (3712.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 4 AUTHORS: PMID:9214289 NOTES:MM
is described by: ECO:0000269
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110025#_e179678c_dfab_481a_9baf_022f57a6aa55
name: SLC6A5
constant: false
is encoded by: hsa:9152
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
is: Q9Y345

metaR EX 5thf LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (THF) exchange
type: Reaction

metaM HC02180 e
has only substance units: false
boundary condition: false
is: CHEBI:28728
initial concentration: 1.0
constant: false
is: SBO:0000247
name: thromboxane-b2
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_f62eb1cd_a084_401f_851a_5a9066f58205
has only substance units: false
type: Species
initial concentration: NaN
name: ALDOA
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:226
initial amount: NaN

metaM HC01610 e
name: CoproporphyrinogenI
is: CHEBI:28607
type: Species
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaM HC02208 e
is: CHEBI:27696
initial concentration: 1.0
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
name: prostaglandin-d1
initial amount: NaN
type: Species

metaR PRODt2r
reactant: MODEL1310110025#
modifier: MODEL1310110025#
reversible: true
fast: false
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
is: SBO:0000185
type: Reaction
product: MODEL1310110025#
is described by: ECO:0000304
name: D-proline reversible transport via proton symport

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_3ebeed7b_0576_426f_8d9a_101bfdd43f53
is: SBO:0000252
constant: false
name: _M68895_1_c
is encoded by: hsa:M68895
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110025#_85f8c908_ef34_4e76_a603_385b14962ddc
type: Species
constant: false
is: SBO:0000252
is: E9PB82
name: HSD17B4
is encoded by: hsa:3295
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true

metaM HC02210 c
name: prostaglandin-d3
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
boundary condition: false
is: CHEBI:34939
initial amount: NaN
has only substance units: false
type: Species

metaM ppa c
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
name: propionate
has only substance units: false
is: CHEBI:17272
is: HMDB00237

http://identifiers.org/biomodels.db/MODEL1310110025#_4e80b777_f884_4efb_8cd9_5feaed6b3224
is encoded by: hsa:7264
initial amount: NaN
type: Species
constant: false
boundary condition: true
is: Q13630
name: TSTA3
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR VALTA
product: MODEL1310110025#
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.6.1.42
kinetic law: MODEL1310110025#
reversible: true
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
is: SBO:0000176
type: Reaction
modifier: MODEL1310110025#
name: valine transaminase

metaR FAOXC16080m
product: MODEL1310110025#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110025#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110025#
name: Beta oxidation of long chain fatty acid
is described by: ECO:0000269
modifier: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_8fb2a955_306c_45c3_9fc6_521d7ff50aa2
constant: false
is: SBO:0000252
boundary condition: true
is: O00217
name: NDUFS8
has only substance units: false
initial amount: NaN
is encoded by: hsa:4728
initial concentration: NaN
type: Species

metaR ITCOAL1m
fast: false
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.4
type: Reaction
product: MODEL1310110025#
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
is: SBO:0000176
is described by: ECO:0000304
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
reactant: MODEL1310110025#

metaM acac e
initial amount: NaN
has only substance units: false
is: HMDB00060
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
name: acetoacetate
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: CHEBI:13705

metaM udpgal e
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
is: HMDB00302
initial concentration: 1.0
is: CHEBI:58439
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
constant: false
name: UDP-D-galactose(2-)
is: SBO:0000247

metaM biocyt m
is: HMDB03134
name: Biocytin
type: Species
is: SBO:0000247
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
is: C05552
is: http://identifiers.org/pubchem.compound/7886
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN

metaM ncam e
is: CHEBI:0
is: C00153
initial concentration: 1.0
constant: false
is: HMDB01406
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H6N2O CHARGE: 0
name: Nicotinamide
type: Species
has only substance units: false
is: SBO:0000247

metaR CYOOm3
name: cytochrome c oxidase, mitochondrial Complex IV
reactant: MODEL1310110025#
modifier: MODEL1310110025#
is: SBO:0000185
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
reversible: false
is described by: ECO:0000134
product: MODEL1310110025#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.9.3.1
kinetic law: MODEL1310110025#

metaR H2MTer L
notes: GENE_ASSOCIATION: (55650.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15623507 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110025#
modifier: MODEL1310110025#
fast: false
type: Reaction
product: MODEL1310110025#
name: H2 mannosyltransferase, endoplasmic reticulum
kinetic law: MODEL1310110025#
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110025#_02b9b33f_e05d_437b_add6_671cb724d040
initial concentration: NaN
is encoded by: hsa:549
initial amount: NaN
boundary condition: true
constant: false
name: AUH
is: Q13825
has only substance units: false
type: Species
is: SBO:0000252

metaM dc2coa m
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275
type: Species
is: SBO:0000247
boundary condition: false
name: trans-Dec-2-enoyl-CoA
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:61406
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_da4a0b80_b3a0_4719_863e_42506fbfcb43
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:C7orf24
name: _C7orf24_1_m

metaR RE0512M
product: MODEL1310110025#
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
type: Reaction
fast: false
kinetic law: MODEL1310110025#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
is described by: ECO:0000000
name: RE0512
reactant: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_01c1864f_7673_4319_a8b5_da40abc578ef
constant: false
name: ALDH5A1
is: Q546H9
has only substance units: false
is encoded by: hsa:7915
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_9a843f6a_6154_4dcb_be0a_1fd784929d00
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
is: P41222
type: Species
is encoded by: hsa:5730
is: SBO:0000252
name: PTGDS
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110025#_e5e02659_b24a_463b_9163_d33604d5fa50
boundary condition: true
is: SBO:0000252
is: Q9Y633
has only substance units: false
type: Species
initial amount: NaN
constant: false
name: PDE1A
is encoded by: hsa:5136
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_83edcaff_689d_46ec_950d_50dd4770fca2
is encoded by: hsa:6576
name: SLC25A1
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is: D9HTE9
is: SBO:0000252

metaM fad e
name: Flavin adenine dinucleotide oxidized
is: HMDB01248
is: SBO:0000247
type: Species
is: CHEBI:16238
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
constant: false
is: C00016
initial amount: NaN

metaR RE1845C
product: MODEL1310110025#
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110025#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 4 h[c] from compEHMN reaction as they were not necessary
modifier: MODEL1310110025#
name: RE1845
is version of: http://identifiers.org/ec-code/2.3.1.65
kinetic law: MODEL1310110025#

metaM btamp m
has only substance units: false
is: HMDB04220
type: Species
is: CHEBI:3110
initial concentration: 1.0
is: SBO:0000247
name: Biotinyl-5'-AMP
constant: false
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
initial amount: NaN
boundary condition: false

metaM 44mzym r
is: SBO:0000247
is: HMDB01286
type: Species
initial amount: NaN
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
initial concentration: 1.0
constant: false
has only substance units: false
name: 14-demethyllanosterol
is: CHEBI:18364
boundary condition: false

metaR ALOX52
fast: false
reversible: false
product: MODEL1310110025#
kinetic law: MODEL1310110025#
name: Arachidonate 5-lipoxygenase
type: Reaction
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.13.11.34
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:cofactors + usage still not clear unknown mechanism - biochemistry supported by PMID: 2829172, 11160764
is described by: ECO:0000269
is: SBO:0000176

metaM ile L c
is: HMDB00172
initial concentration: 1.0
type: Species
name: L-isoleucine
is: CHEBI:17191
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_4b0625c7_de77_4fc8_afca_956dd88d24b9
type: Species
is: SBO:0000252
is: Q5QPH3
is encoded by: hsa:55902
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: ACSS2
has only substance units: false
constant: false

metaM dcholcoa x
type: Species
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
is: CHEBI:28701
is: HMDB06292
name: chenodeoxycholoyl coenzyme a
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false

metaM HC02210 e
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:34939
initial amount: NaN
name: prostaglandin-d3
boundary condition: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1

metaM ppa e
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:17272
is: HMDB00237
name: propionate
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_13c890a3_36fa_46a6_ba4e_89702f8784f2
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

metaR r2360
is described by: ECO:0000000
is: SBO:0000185
reversible: true
name: Organic anion transporter 5 Utilized transport
type: Reaction
reactant: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110025#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110025#_649dbb2e_274e_4366_b7bc_075ff0a11ea7
name: DGKI
type: Species
initial amount: NaN
is: O75912
has only substance units: false
boundary condition: true
is encoded by: hsa:9162
is: SBO:0000252
initial concentration: NaN
constant: false

metaM Rtotalcoa c
is: SBO:0000247
has only substance units: false
constant: false
name: R total Coenzyme A
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:16189
is: HMDB01448
initial amount: NaN
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4

metaM cmpacna g
has only substance units: false
is: HMDB01176
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: CHEBI:57812
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
constant: false
name: CMP-N-acetyl-beta-neuraminate(2-)

http://identifiers.org/biomodels.db/MODEL1310110025#_e4279f7a_6d45_4829_9c76_edb68ce25bff
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:10559
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: SLC35A1
constant: false
is: P78382

metaR SRTNtu
reactant: MODEL1310110025#
is: SBO:0000185
modifier: MODEL1310110025#
type: Reaction
fast: false
is described by: ECO:0000269
name: Serotonin uniport
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (6580.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
reversible: true
product: MODEL1310110025#

metaR CRNtx
is: SBO:0000185
product: MODEL1310110025#
type: Reaction
reactant: MODEL1310110025#
name: carnitine transport peroxisome to mitochondria
fast: false
kinetic law: MODEL1310110025#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12814641,PMID:15464416 NOTES:mechanism not currently elucidated NJ
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110025#_f01a8799_3a85_4596_b7fe_4c1483e39c90
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: CPT1C
constant: false
is: Q8TCG5
type: Species
is encoded by: hsa:126129

metaR FRDPtcr
is: SBO:0000185
is described by: ECO:0000134
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
product: MODEL1310110025#
type: Reaction
fast: false
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
reversible: true

metaM betald c
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
is: HMDB01252
name: betaine aldehyde
constant: false
has only substance units: false
is: CHEBI:15710
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR SPHK21c
reversible: false
name: sphingosine kinase 2
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.7.1.91
type: Reaction
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
is: SBO:0000176
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NJ

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_7faceb37_fe16_490e_91c8_47080a59dfec
boundary condition: true
initial amount: NaN
has only substance units: false
name: HADHA
initial concentration: NaN
constant: false
is encoded by: hsa:3030
type: Species
is: SBO:0000252
is: E9KL44

metaM pep c
is: HMDB00263
is: CHEBI:18021
name: Phosphoenolpyruvate
is: SBO:0000247
initial concentration: 1.0
is: C00074
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_baf2e77e_02ea_4c54_9af5_666c489498a9
has only substance units: false
type: Species
name: NT5M
initial concentration: NaN
is encoded by: hsa:56953
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
is: Q9NPB1

http://identifiers.org/biomodels.db/MODEL1310110025#_c3b8fd9e_afdd_4c6d_a336_55284c706ddf
initial amount: NaN
is encoded by: hsa:314
type: Species
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
name: AOC2
is: SBO:0000252

metaM hdca c
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: HMDB00220
is: CHEBI:7896
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: palmitate
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110025#_3ffe47e5_2b87_4d1e_9730_37ca8c9c32c2
is: B3KRZ3
initial amount: NaN
name: IMPDH1
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:3614
boundary condition: true
has only substance units: false

metaR MHISOR
modifier: MODEL1310110025#
reversible: false
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (26.1) or (314.1) or (8639.1) or (314.2) SUBSYSTEM: Histidine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:12072962,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:
product: MODEL1310110025#
name: N-Methylhistamine:oxygen oxidoreductase (deaminating)
is version of: http://identifiers.org/ec-code/1.4.3.22
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.21

metaR DM gpi sig er
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gpi sig(er)
type: Reaction

metaR r2361
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110025#
is described by: ECO:0000000
product: MODEL1310110025#
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110025#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR SPRMTDe
name: absorption for spermine across the basolateral side
fast: false
reactant: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000134
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: Larqu? E, Sabater-Molina M, Zamora S. (2007). Nutrition 23: 87-95, PMID: 11564949. NOTES:polyamines are taken up by diffusion process, although specific carriers and para-cellular transport has also been documented.
kinetic law: MODEL1310110025#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_3bd70193_5de6_449e_803c_f156211b32a3
is: P40394
is encoded by: hsa:131
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: ADH7
type: Species
constant: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110025#_a683889e_0543_492f_88c3_b9e652dff5cf
is: B3KTV4
is encoded by: hsa:122622
type: Species
name: ADSSL1
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false

metaR FAEL205
is described by: ECO:0000000
modifier: MODEL1310110025#
product: MODEL1310110025#
fast: false
type: Reaction
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
reversible: false
name: fatty-acyl-CoA elongation (n-C20:5CoA)
kinetic law: MODEL1310110025#
is: SBO:0000176

metaR 2MCITt
product: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:426765 NOTES:MM
is: SBO:0000185
kinetic law: MODEL1310110025#
fast: false
reversible: true
name: 2-methylcitrate transport via diffusion
reactant: MODEL1310110025#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110025#_02c3f8aa_b377_4601_bd74_48b39a06fd23
is: Q86YW0
boundary condition: true
has only substance units: false
is encoded by: hsa:89869
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
name: PLCZ1
initial concentration: NaN

metaR PROSTGE1t
is described by: ECO:0000269
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
product: MODEL1310110025#
is: SBO:0000185
type: Reaction
name: prostaglandin transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
reversible: true
fast: false
reactant: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_73660b27_d7b2_4aa7_842f_f2e47c36cfb5
boundary condition: true
is: Q9UKG4
name: SLC13A4
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:26266
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaR C204CRNt
reversible: false
is described by: ECO:0000000
name: arachidonic acid transport into the mitochondria
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV C20:4 transport
kinetic law: MODEL1310110025#
is: SBO:0000185
reactant: MODEL1310110025#
product: MODEL1310110025#
fast: false
type: Reaction

metaR EX phe L LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-phenylalanine
type: Reaction

metaM mi14p c
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
is: HMDB00968
initial concentration: 1.0
boundary condition: false
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
is: CHEBI:58282

http://identifiers.org/biomodels.db/MODEL1310110025#_3992b7e8_4ce8_4133_bcd1_c680f1c5aa2c
name: DPM2
is encoded by: hsa:8818
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
type: Species

metaM HC02214 e
is: CHEBI:28852
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
name: prostaglandin-f1alpha
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0

metaR DURAD
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.3.1.2
is: SBO:0000176
product: MODEL1310110025#
reversible: true
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
fast: false
modifier: MODEL1310110025#
name: dihydrouracil dehydrogenase (NADP)
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110025#

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_7510a840_d1b3_4b7c_882c_180a91e452da
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:AA081045
type: Species
constant: false
initial concentration: NaN
name: _AA081045_1_e

metaR r2362
is: SBO:0000185
is described by: ECO:0000000
reversible: true
name: Organic anion transporter 5 Utilized transport
type: Reaction
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110025#
fast: false
product: MODEL1310110025#

metaM icit c
boundary condition: false
is: C00311
is: SBO:0000247
name: Isocitrate
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:16087
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
initial amount: NaN
has only substance units: false
is: HMDB00193

metaR FAEL204
product: MODEL1310110025#
fast: false
reactant: MODEL1310110025#
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110025#
reversible: false
kinetic law: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
name: fatty-acyl-CoA elongation (n-C20:4CoA)

http://identifiers.org/biomodels.db/MODEL1310110025#_9d26443d_e791_4b9b_a661_d131ab62ea7c
boundary condition: true
constant: false
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: P54687
is encoded by: hsa:586
name: BCAT1

http://identifiers.org/biomodels.db/MODEL1310110025#_35f7d72f_8bc8_4efd_bef9_23fdffd097e0
constant: false
has only substance units: false
type: Species
initial concentration: NaN
is: Q6ZWP6
is: SBO:0000252
boundary condition: true
name: ACAD8
is encoded by: hsa:27034
initial amount: NaN

metaR GACPAILter
fast: false
reversible: false
product: MODEL1310110025#
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
name: glucosaminyl-acylphosphatidylinositol ER flippase
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14517336 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000185
type: Reaction

metaR FATP2t
type: Reaction
is: SBO:0000185
name: fatty acid electroneutral transport
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
modifier: MODEL1310110025#
fast: false
reversible: true
product: MODEL1310110025#
is described by: ECO:0000269

metaR r2363
fast: false
reactant: MODEL1310110025#
product: MODEL1310110025#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110025#
name: Organic anion transporter 5 Utilized transport

metaM dolmanp L c
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
name: Dolichyl phosphate D-mannose, human liver homolog
is: CHEBI:15809

metaM 3mop c
has only substance units: false
type: Species
constant: false
is: SBO:0000247
name: 3-methyl-2-oxopentanoate
initial concentration: 1.0
boundary condition: false
is: HMDB00491
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
initial amount: NaN
is: CHEBI:28654

metaR AICARte
is described by: ECO:0000134
reactant: MODEL1310110025#
product: MODEL1310110025#
is: SBO:0000185
kinetic law: MODEL1310110025#
name: Transport of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110025#_555e5d2c_a786_44c7_911a_96312d8522c5
boundary condition: true
type: Species
is encoded by: hsa:80025
name: PANK2
initial amount: NaN
is: Q9BZ23
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_1e1fdebe_e538_4dc9_bcb7_049f44f05856
initial amount: NaN
has only substance units: false
type: Species
name: PCYT1B
is encoded by: hsa:9468
constant: false
boundary condition: true
is: SBO:0000252
is: E9PD84
initial concentration: NaN

metaM hestratriol e
initial amount: NaN
name: 4,17 dihydroxy estradiol
type: Species
is: HMDB05896
constant: false
initial concentration: 1.0
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
boundary condition: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110025#_1014d19a_a1fe_48be_9541_cd5739890b06
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: Q9Y2D0
has only substance units: false
name: CA5B
constant: false
initial amount: NaN
is encoded by: hsa:11238
type: Species

metaM itaccoa m
name: itaconyl-CoA(5-)
initial amount: NaN
is: SBO:0000247
is: HMDB03377
type: Species
initial concentration: 1.0
is: CHEBI:57381
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
has only substance units: false
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_4449e140_335a_4f97_a114_0da506383e60
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000297
has part: P00326
initial concentration: NaN
name: ADH1A:ADH1C
type: Species
is encoded by: hsa:126

http://identifiers.org/biomodels.db/MODEL1310110025#_0ada237c_b260_4488_b056_90b720aaddee
initial concentration: NaN
is encoded by: hsa:53
is: SBO:0000252
name: ACP2
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
type: Species
is: E9PCI1

metaM clpndcoa x
name: clupanodonyl CoA
boundary condition: false
initial amount: NaN
is: HMDB06267
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205476
constant: false
initial concentration: 1.0
is: C16166
is: SBO:0000247
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1

metaR r0539
modifier: MODEL1310110025#
is: SBO:0000176
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.1.1.34
is described by: ECO:0000000
type: Reaction
reversible: true
product: MODEL1310110025#
name: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19
reactant: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:

metaM HC02214 c
boundary condition: false
type: Species
constant: false
is: CHEBI:28852
initial concentration: 1.0
initial amount: NaN
name: prostaglandin-f1alpha
has only substance units: false
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
is: SBO:0000247

metaR GLCt4
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
reversible: true
kinetic law: MODEL1310110025#
type: Reaction
is described by: ECO:0000269
fast: false
product: MODEL1310110025#
is: SBO:0000185
reactant: MODEL1310110025#
modifier: MODEL1310110025#
name: glucose transport via sodium symport

metaM gchola c
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
boundary condition: false
is: SBO:0000247
name: glycocholate
has only substance units: false
is: CHEBI:58235
is: HMDB00138
type: Species

metaR ARACHDCOAtx
type: Reaction
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
kinetic law: MODEL1310110025#
reversible: true
is: SBO:0000185
product: MODEL1310110025#
is described by: ECO:0000000
fast: false
name: fatty acid intracellular transport

metaM accoa c
is: HMDB01206
is: CHEBI:57288
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
name: Acetyl-CoA
is: SBO:0000247
has only substance units: false
is: C00024
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024

metaR GTHDH
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15970797,PMID:16399380 NOTES:NCD. activity catalyzed by GSTO2-2
name: Glutathione dehydrogenase (dehydroascorbate reductase)
reactant: MODEL1310110025#
is: SBO:0000176
kinetic law: MODEL1310110025#
product: MODEL1310110025#
type: Reaction
reversible: false
fast: false
is described by: ECO:0000134

metaM f6p c
initial amount: NaN
name: D-Fructose 6-phosphate
has only substance units: false
type: Species
is: HMDB00124
is: http://identifiers.org/pubchem.compound/3385
is: C00085
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:57579

metaR 4HGLSDm
kinetic law: MODEL1310110025#
is described by: ECO:0000212
modifier: MODEL1310110025#
name: L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
type: Reaction
fast: false
reversible: true
is: SBO:0000176
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.5.1.12

metaM acac c
constant: false
is: CHEBI:13705
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
type: Species
initial amount: NaN
has only substance units: false
is: HMDB00060
boundary condition: false
name: acetoacetate

metaR r2364
is described by: ECO:0000000
kinetic law: MODEL1310110025#
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
type: Reaction
is: SBO:0000185
reversible: true

metaR G6PDH1rer
product: MODEL1310110025#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.47
kinetic law: MODEL1310110025#
name: glucose-6-phosphate dehydrogenase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:tv, jp NCD
is: SBO:0000176
reactant: MODEL1310110025#
reversible: true
modifier: MODEL1310110025#
fast: false

metaM cytd m
type: Species
is: SBO:0000247
initial amount: NaN
name: cytidine
is: HMDB00089
initial concentration: 1.0
is: CHEBI:17562
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C9H13N3O5 CHARGE: 0 INCHI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475

metaM ficytC m
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
name: Ferricytochrome c
is: CHEBI:15991
constant: false
has only substance units: false

metaR HMGCOAtm
type: Reaction
reactant: MODEL1310110025#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110025#
is: SBO:0000185
reversible: true
name: Hydroxymethylglutaryl-CoA reversible mitochondrial transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:NCD
product: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_14852ff5_8ce7_4be7_8f8a_c3f07c77a52e
constant: false
is: SBO:0000252
is encoded by: hsa:57665
is: Q9HBH5
initial amount: NaN
has only substance units: false
name: RDH14
type: Species
initial concentration: NaN
boundary condition: true

metaR PAIL4P HStn
product: MODEL1310110025#
reversible: true
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
is: SBO:0000185
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110025#_f11a9752_9988_4810_bc90_708ef2c4b1d2
initial concentration: NaN
type: Species
is: SBO:0000252
name: SLC7A6
constant: false
is encoded by: hsa:9057
has only substance units: false
is: Q92536
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110025#_a3706454_e2d6_42e3_962d_d25439a39813
constant: false
is encoded by: hsa:1609
is: P52824
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
name: DGKQ
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_7a36515b_572e_4519_b565_474fe444aa7c
initial amount: NaN
type: Species
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:T83654
name: _T83654_1_m
has only substance units: false
is: SBO:0000252

metaM ncam c
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C6H6N2O CHARGE: 0
is: HMDB01406
is: CHEBI:0
is: C00153
constant: false
name: Nicotinamide
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR BHBt
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
is: SBO:0000185
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reactant: MODEL1310110025#

metaM pyr e
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
initial concentration: 1.0
boundary condition: false
type: Species
name: pyruvate
constant: false
has only substance units: false
is: HMDB00243
is: SBO:0000247
initial amount: NaN
is: CHEBI:15361

http://identifiers.org/biomodels.db/MODEL1310110025#_cd0fbabe_a153_4a8f_9556_dca9197b7b98
initial concentration: NaN
type: Species
constant: false
is: P42765
is encoded by: hsa:10449
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: ACAA2
has only substance units: false

metaR ASCBOX
reactant: MODEL1310110025#
reversible: false
kinetic law: MODEL1310110025#
product: MODEL1310110025#
type: Reaction
is: SBO:0000176
name: ascorbic acid oxidase
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
fast: false

metaM fad c
is: HMDB01248
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:16238
initial concentration: 1.0
type: Species
is: C00016
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
constant: false
initial amount: NaN
name: Flavin adenine dinucleotide oxidized

metaR NDP10ex
is described by: ECO:0000269
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/3.6.1.6
is: SBO:0000176
reversible: false
reactant: MODEL1310110025#
modifier: MODEL1310110025#
type: Reaction
name: nucleoside-diphosphatase (IDP), extracellular
fast: false
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110025#_ea3d0f9a_74d0_4cae_a068_64dca4af7c3c
name: ALG10
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
is: Q5BKT4
boundary condition: true
is encoded by: hsa:84920

metaR r2365
kinetic law: MODEL1310110025#
fast: false
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
product: MODEL1310110025#
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110025#

metaR r0377
product: MODEL1310110025#
reactant: MODEL1310110025#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
is: SBO:0000176
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.4.3
type: Reaction
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#

metaR ACt2r
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
is described by: ECO:0000000
fast: false
reversible: true
name: acetate reversible transport via proton symport
type: Reaction
is: SBO:0000185

metaM hestratriol c
boundary condition: false
constant: false
initial amount: NaN
is: HMDB05896
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
name: 4,17 dihydroxy estradiol
has only substance units: false

metaM 3mop e
name: 3-methyl-2-oxopentanoate
boundary condition: false
is: CHEBI:28654
initial concentration: 1.0
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
constant: false
is: SBO:0000247
type: Species
is: HMDB00491
has only substance units: false
initial amount: NaN

metaR NADS2
is described by: ECO:0000269
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.5.1
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
is: SBO:0000176
name: NAD synthase (glutamine-hydrolysing)
reactant: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (55191.1) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false

metaR RE1573M
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/5.3.3.8
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110025#
name: RE1573
type: Reaction
reactant: MODEL1310110025#
fast: false
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

metaR KHte
name: KHte
fast: false
is described by: ECO:0000134
type: Reaction
reactant: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
kinetic law: MODEL1310110025#
is: SBO:0000185

metaR VALt4
product: MODEL1310110025#
reactant: MODEL1310110025#
fast: false
name: L-valine transport in via sodium symport
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
type: Reaction
reversible: false
is: SBO:0000185

metaR XOLDIOLONEt
is described by: ECO:0000000
type: Reaction
reversible: true
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
fast: false
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
is: SBO:0000185
product: MODEL1310110025#

metaR O2ter
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: O2 transport, endoplasmic reticulum
product: MODEL1310110025#
reversible: true
reactant: MODEL1310110025#
is: SBO:0000185
kinetic law: MODEL1310110025#

metaR THP2Ctp
reactant: MODEL1310110025#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate transport, peroxisomal
kinetic law: MODEL1310110025#
is described by: ECO:0000000
product: MODEL1310110025#
reversible: true
type: Reaction
fast: false

metaR r2366
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110025#
fast: false
reactant: MODEL1310110025#
type: Reaction
kinetic law: MODEL1310110025#
name: Organic anion transporter 5 Utilized transport

metaR r0941
reactant: MODEL1310110025#
is described by: ECO:0000000
kinetic law: MODEL1310110025#
name: Free diffusion
reversible: true
fast: false
product: MODEL1310110025#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:
type: Reaction

metaM cytd c
constant: false
name: Cytidine
is: HMDB00089
boundary condition: false
initial concentration: 1.0
is: C00475
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:17562

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

metaR GluForTx
modifier: MODEL1310110025#
fast: false
reactant: MODEL1310110025#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.2.5
product: MODEL1310110025#
reversible: false
kinetic law: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Histidine metabolism EC Number: 2.1.2.5 Confidence Level: 4 AUTHORS: PMID:12815595 NOTES:SAB
name: Glutamate formimidoyltransferase
is described by: ECO:0000269

metaM lac D c
is: CHEBI:16004
constant: false
initial amount: NaN
is: HMDB01311
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
initial concentration: 1.0
name: (R)-lactate

http://identifiers.org/biomodels.db/MODEL1310110025#_b0502093_b5b7_4f73_9b80_68c7d1664876
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
name: ALDH3B2
is: SBO:0000252
is: P48448
constant: false
initial concentration: NaN
is encoded by: hsa:222

http://identifiers.org/biomodels.db/MODEL1310110025#_3b829f4b_198a_4ef2_b767_c70c5376d2d2
is: Q8WUD6
is encoded by: hsa:56994
is: SBO:0000252
has only substance units: false
name: CHPT1
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110025#_1e363aae_e9a5_49db_91aa_787be21ae5b7
type: Species
initial amount: NaN
name: PDE8A
is: SBO:0000252
is encoded by: hsa:5151
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false

metaR AACTOOR
notes: GENE_ASSOCIATION: (8639.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.4.3.6 Confidence Level: 4 AUTHORS: PMID:10328770,PMID:12878330 NOTES:
modifier: MODEL1310110025#
reversible: false
is version of: http://identifiers.org/ec-code/1.4.3.21
is described by: ECO:0000269
reactant: MODEL1310110025#
type: Reaction
name: Aminoacetone:oxygen oxidoreductase(deaminating)(flavin-containing)
kinetic law: MODEL1310110025#
is: SBO:0000176
fast: false
product: MODEL1310110025#

metaM Rtotal e
is: CHEBI:3554
is: HMDB00244
type: Species
is: C00255
initial concentration: 1.0
constant: false
has only substance units: false
name: R total
notes: FORMULA: CO2FULLR CHARGE: -1
initial amount: NaN
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110025#_75bf01fa_88ec_4b3a_8494_858fb696e0b5
initial concentration: NaN
type: Species
boundary condition: true
name: PLCG1
has only substance units: false
is: Q9UFY1
is: SBO:0000252
constant: false
is encoded by: hsa:5335
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_63876408_9623_4200_9c1f_f59a49234529
has only substance units: false
initial amount: NaN
is: O43865
is encoded by: hsa:10768
boundary condition: true
type: Species
constant: false
initial concentration: NaN
name: AHCYL1
is: SBO:0000252

metaR r2367
reactant: MODEL1310110025#
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110025#
fast: false
type: Reaction
product: MODEL1310110025#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaM pyr c
is: C00022
constant: false
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:15361
is: http://identifiers.org/pubchem.compound/3324
name: pyruvate
initial amount: NaN
is: HMDB00243
initial concentration: 1.0
notes: FORMULA: C3H3O3 CHARGE: -1

metaR DCK2n
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
type: Reaction
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.7.1.74
is: SBO:0000176
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reactant: MODEL1310110025#
name: Deoxycytidine kinase, nuclear (UTP)
fast: false

metaR FAOXC1811603m
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110025#
is described by: ECO:0000269
name: Beta oxidation fatty acid
reactant: MODEL1310110025#
is: SBO:0000176
fast: false
product: MODEL1310110025#

metaR r0940
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110025#
product: MODEL1310110025#
kinetic law: MODEL1310110025#
reversible: true
is described by: ECO:0000000
name: Free diffusion

http://identifiers.org/biomodels.db/MODEL1310110025#_7d5ae845_04fd_4f18_ac8a_973e323e2d51
initial amount: NaN
initial concentration: NaN
name: SLC25A6
boundary condition: true
has only substance units: false
is encoded by: hsa:293
is: SBO:0000252
type: Species
is: Q6I9V5
constant: false

metaR DOLPMT4 Ler
fast: false
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
is: SBO:0000185
is described by: ECO:0000000
reversible: false
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
type: Reaction
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:

metaR PROD2m
fast: false
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.5.99.8
is described by: ECO:0000254
type: Reaction
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR SAB m
kinetic law: MODEL1310110025#
product: MODEL1310110025#
name: Proline dehydrogenase (m)
reversible: false
is: SBO:0000176

metaM biocyt e
is: C05552
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
is: http://identifiers.org/pubchem.compound/7886
name: Biocytin
boundary condition: false
is: HMDB03134
type: Species

metaR RE3001M
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.3.1.34
name: RE3001
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
fast: false
reactant: MODEL1310110025#
type: Reaction
modifier: MODEL1310110025#
is: SBO:0000176

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

metaM ala D e
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: D-alanine
constant: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
is: HMDB01310
initial concentration: 1.0
is: CHEBI:15570

metaM hdd2coa m
type: Species
initial concentration: 1.0
is: C05272
initial amount: NaN
boundary condition: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
is: HMDB03945
name: trans-Hexadec-2-enoyl-CoA
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:61526

http://identifiers.org/biomodels.db/MODEL1310110025#_0450d7b3_da14_43df_ae6b_8282cdd7a196
is: Q8N1G6
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: GPAM
has only substance units: false
initial concentration: NaN
is encoded by: hsa:57678

http://identifiers.org/biomodels.db/MODEL1310110025#_126b8245_2192_4ce2_84a2_76318fc1bce9
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:80308
name: FLAD1
type: Species
boundary condition: true
constant: false
initial concentration: NaN

metaM idp e
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB03335
initial amount: NaN
initial concentration: 1.0
name: IDP(3-)
is: CHEBI:58280
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
constant: false

metaR HSD17B4x
type: Reaction
reactant: MODEL1310110025#
fast: false
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
reversible: false
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000269
product: MODEL1310110025#
name: hydroxysteroid (17-beta) dehydrogenase 4
is: SBO:0000176

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

metaR r2368
reactant: MODEL1310110025#
type: Reaction
reversible: true
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110025#
fast: false
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
is described by: ECO:0000000

metaR r0410
is described by: ECO:0000000
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
reactant: MODEL1310110025#
type: Reaction
reversible: true
fast: false
product: MODEL1310110025#
kinetic law: MODEL1310110025#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:

metaR GLYt4
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:SAB irreversible
fast: false
kinetic law: MODEL1310110025#
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110025#
name: glycine transport via sodium symport
product: MODEL1310110025#
type: Reaction
modifier: MODEL1310110025#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110025#_2dacb8ae_ac1c_4c7a_8a0f_39da51753874
name: SLC13A5
is: SBO:0000252
initial concentration: NaN
is: Q86YT5
is encoded by: hsa:284111
constant: false
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false

metaR r0267
kinetic law: MODEL1310110025#
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
product: MODEL1310110025#
reversible: true
reactant: MODEL1310110025#
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.9
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110025#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_63275872_ecf0_41ee_8c14_0266a330fcb5
boundary condition: true
constant: false
name: UCK1
has only substance units: false
initial amount: NaN
type: Species
is: Q5JT09
is: SBO:0000252
is encoded by: hsa:83549
initial concentration: NaN

metaM fadh2 c
initial amount: NaN
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
is: HMDB01197
type: Species
is: SBO:0000247
constant: false
has only substance units: false
name: FADH2(2-)
initial concentration: 1.0
is: CHEBI:58307
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110025#_9c85f81d_1d1e_47e7_ad7c_955ad3f42f5f
constant: false
name: SLC23A2
is encoded by: hsa:9962
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is: Q9UGH3
is: SBO:0000252
has only substance units: false

metaR LDH D
modifier: MODEL1310110025#
name: D-lactate dehydrogenase
is described by: ECO:0000304
product: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)
kinetic law: MODEL1310110025#
reversible: true
is: SBO:0000176
fast: false
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.1.2.4

metaM HC01223 m
constant: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
is: CHEBI:57340
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
is: SBO:0000247
type: Species

metaM thf e
boundary condition: false
notes: FORMULA: C19H21N7O6 CHARGE: -2 INCHI: InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
is: SBO:0000247
initial amount: NaN
name: (6S)-5,6,7,8-tetrahydrofolate(2-)
constant: false
is: CHEBI:57453
initial concentration: 1.0
has only substance units: false
is: HMDB01846
type: Species

metaR P45027A11m
is described by: ECO:0000269
product: MODEL1310110025#
modifier: MODEL1310110025#
name: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.15
type: Reaction
reversible: false
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ
fast: false
reactant: MODEL1310110025#

metaM ethamp r
is: CHEBI:58190
initial concentration: 1.0
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
boundary condition: false
initial amount: NaN
type: Species
name: O-phosphonatoethanaminium(1-)
constant: false
has only substance units: false
is: HMDB00224
is: SBO:0000247

metaM CE2417 m
is: CHEBI:28387
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
is: HMDB11123
type: Species
initial concentration: 1.0
boundary condition: false
constant: false

metaR NS26T2g
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.4.99.3
name: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
reactant: MODEL1310110025#
type: Reaction
kinetic law: MODEL1310110025#
reversible: false
notes: GENE_ASSOCIATION: (55808.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.3 Confidence Level: 0 AUTHORS: PMID:10536037 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110025#
fast: false
is: SBO:0000176

metaM Rtotal c
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:16189
name: R total
constant: false
notes: FORMULA: CO2FULLR CHARGE: -1
initial amount: NaN
boundary condition: false
is: HMDB01448

metaM cmpacna n
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
type: Species
initial concentration: 1.0
name: CMP-N-acetyl-beta-neuraminate(2-)
is: HMDB01176
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:57812

metaR r2369
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
type: Reaction
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110025#
is: SBO:0000185
product: MODEL1310110025#
reactant: MODEL1310110025#
reversible: true

metaR r0268
product: MODEL1310110025#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.2
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
modifier: MODEL1310110025#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.3.1
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
is: SBO:0000176
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
is described by: ECO:0000000

metaR r0942
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
fast: false
type: Reaction
product: MODEL1310110025#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:

metaM cspg a l
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB06202
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
constant: false

metaM btamp c
name: Biotinyl-5'-AMP
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:3110
type: Species
is: HMDB04220
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921

http://identifiers.org/biomodels.db/MODEL1310110025#_5590d510_64ca_420a_8571_ec94212ce4cc
name: ALDH2
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
is: P05091
initial amount: NaN
is encoded by: hsa:217
has only substance units: false
constant: false

metaR r0647
type: Reaction
is described by: ECO:0000000
name: Spontaneous reaction
product: MODEL1310110025#
fast: false
reversible: true
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
kinetic law: MODEL1310110025#
is: SBO:0000176

metaR r1538
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.17.4.1
is described by: ECO:0000000
name: Anion Exchanger (AE) TCDB:2.A.31.2.8
modifier: MODEL1310110025#
type: Reaction
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
is: SBO:0000185
product: MODEL1310110025#

metaM dha e
initial amount: NaN
is: HMDB01882
name: glycerone
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:16016
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110025#_c501c123_040d_4980_9559_1460a4394f51
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
name: PIGS
is: Q8NBL9
initial concentration: NaN
constant: false
is encoded by: hsa:94005
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_a95cf769_00c7_457c_ba0e_e114ec23b6c5
is encoded by: hsa:3156
initial concentration: NaN
name: HMGCR
boundary condition: true
constant: false
is: P04035
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN

metaM biocyt c
initial concentration: 1.0
is: C05552
constant: false
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
is: SBO:0000247
name: Biocytin
initial amount: NaN
is: http://identifiers.org/pubchem.compound/7886
boundary condition: false
type: Species
is: HMDB03134
has only substance units: false

metaM dmnoncrn x
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
name: 4,8-dimethylnonanoyl carnitine
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C18H37NO4 CHARGE: 0
type: Species
is: HMDB06202

metaM 2mbcoa m
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
is: HMDB01041
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
boundary condition: false
is: CHEBI:57336
initial concentration: 1.0
name: 2-methylbutanoyl-CoA(4-)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_0b951a72_8c8b_499d_ab97_d31568f83277
is: E5KSL6
boundary condition: true
initial amount: NaN
name: DGUOK
initial concentration: NaN
is encoded by: hsa:1716
constant: false
type: Species
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110025#_60610af4_656b_4b76_bada_2b2f48d67758
initial amount: NaN
type: Species
constant: false
name: ADHFE1
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:137872
boundary condition: true
is: Q8IWW8
has only substance units: false

metaM dcholcoa r
name: chenodeoxycholoyl coenzyme a
constant: false
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB06292
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28701
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337

metaR r0642
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110025#
reversible: true
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
type: Reaction
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:

metaM asp L c
is: CHEBI:29991
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
is: HMDB00191
name: L-aspartate(1-)

http://identifiers.org/biomodels.db/MODEL1310110025#_d6674f07_6343_469c_8a17_40dc8775632e
initial amount: NaN
is: P47989
boundary condition: true
is encoded by: hsa:7498
is: SBO:0000252
initial concentration: NaN
name: XDH
constant: false
has only substance units: false
type: Species

metaM ala D c
name: D-alanine
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB01310
initial amount: NaN
is: SBO:0000247
is: CHEBI:15570
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
type: Species

metaM dadp m
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
has only substance units: false
name: dADP(3-)
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:57667
type: Species
is: HMDB01508
constant: false

metaM 6hoxmelatn c
is: HMDB04081
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C13H16N2O3 CHARGE: 0 INCHI: InChI=1/C13H16N2O3/c1-8(16)14-4-3-9-7-15-11-6-12(17)13(18-2)5-10(9)11/h5-7,15,17H,3-4H2,1-2H3,(H,14,16) EHMN_ABBREVIATION: C05643
has only substance units: false
is: http://identifiers.org/pubchem.compound/7954
is: C05643
boundary condition: false
name: 6-Hydroxymelatonin
type: Species

metaM idp c
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB03335
type: Species
initial concentration: 1.0
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
initial amount: NaN
name: IDP(3-)
is: CHEBI:58280
boundary condition: false

metaR ITCOALm
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
reactant: MODEL1310110025#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.5
product: MODEL1310110025#
fast: false
reversible: true
kinetic law: MODEL1310110025#
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
is described by: ECO:0000212
type: Reaction
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/6.2.1.4

metaM ile L e
is: CHEBI:17191
initial concentration: 1.0
has only substance units: false
is: HMDB00172
name: L-isoleucine
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
boundary condition: false
type: Species
is: SBO:0000247
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_5058d6c9_6e0b_43ec_8c3a_afeeba816ea0
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:642502
initial amount: NaN
name: _642502_1_c
is: SBO:0000252
has only substance units: false
boundary condition: true

metaM cs b deg3 l
boundary condition: false
is: CHEBI:21338
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB02704
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 3
initial amount: NaN
notes: FORMULA: C37H55NO38S2 CHARGE: -4
has only substance units: false
type: Species

metaM thf c
is: CHEBI:57453
name: 5,6,7,8-Tetrahydrofolate
type: Species
is: SBO:0000247
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
initial concentration: 1.0
initial amount: NaN
is: C00101
boundary condition: false
has only substance units: false
constant: false
is: HMDB01846

http://identifiers.org/biomodels.db/MODEL1310110025#_9e73435e_5292_48ce_86f9_5e86fbece6a2
is encoded by: hsa:1347
type: Species
name: COX7A2
is: H0UI06
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_34c760dc_7fdf_4fe9_90ed_8a40f59db5f0
is: SBO:0000252
constant: false
name: _AI291895_1_c
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI291895

metaR r0944
product: MODEL1310110025#
name: Active transport
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
type: Reaction
is described by: ECO:0000000
reversible: true

metaM cs a deg2 l
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
constant: false
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 2
is: HMDB00127
notes: FORMULA: C37H55NO38S2 CHARGE: -4
boundary condition: false
initial amount: NaN
is: CHEBI:15748

http://identifiers.org/biomodels.db/MODEL1310110025#_be7c44b3_e53d_4fac_8bef_bf38c558f608
boundary condition: true
is: Q8N142
constant: false
initial amount: NaN
is encoded by: hsa:122622
name: ADSSL1
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false

metaR r0641
fast: false
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
modifier: MODEL1310110025#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
product: MODEL1310110025#
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/3.1.2.4

metaM dadp n
is: SBO:0000247
is: CHEBI:57667
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
type: Species
is: HMDB01508
name: dADP(3-)
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_1c0de2a8_6628_4874_9d39_68e33b660fb0
initial concentration: NaN
is: O94903
boundary condition: true
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:11212
name: PROSC

http://identifiers.org/biomodels.db/MODEL1310110025#_b5f2ef63_bc62_4a4a_8735_19eaa92567df
boundary condition: true
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AI972237
name: _AI972237_1_c

http://identifiers.org/biomodels.db/MODEL1310110025#_0befc90e_a308_46b2_a40c_1bb4c64993db
is: P06744
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
constant: false
name: GPI
is: SBO:0000252
is encoded by: hsa:2821
initial concentration: NaN

metaM dttp m
constant: false
type: Species
is: CHEBI:37568
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
has only substance units: false
is: HMDB01342
is: SBO:0000247
is: C00459
boundary condition: false
name: dTTP

metaR MALTSULtm
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
fast: false
type: Reaction
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
name: Malate:thiosulfate antiport, mitochondrial
reactant: MODEL1310110025#
reversible: true
product: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_2b78498e_865b_4eb5_8cfa_b72bc37dc80c
boundary condition: true
initial amount: NaN
is encoded by: hsa:2805
type: Species
is: P17174
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
name: GOT1

metaM retinal c
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
is: CHEBI:15035
name: retinal
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB01358

metaM hdca e
is: HMDB00220
boundary condition: false
notes: FORMULA: C16H31O2 CHARGE: -1
type: Species
is: SBO:0000247
constant: false
is: C00249
initial concentration: 1.0
is: CHEBI:0
name: Hexadecanoate (n-C16:0)
initial amount: NaN
has only substance units: false

metaM succ x
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
initial amount: NaN
name: Succinate
is: C00042
is: CHEBI:30031
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00254
is: SBO:0000247

metaM xyl D l
constant: false
is: SBO:0000247
is: CHEBI:15936
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
name: aldehydo-D-xylose

metaM sT antigen g
name: sialyl-T antigen
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C25H40N2O18X CHARGE: -1
is: CHEBI:16565

metaR NAIt
is described by: ECO:0000269
modifier: MODEL1310110025#
reactant: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
name: Na+ / iodide cotransport
fast: false
reversible: true
kinetic law: MODEL1310110025#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_0cd3b760_b6a0_4770_9570_ba61519c26dd
is: SBO:0000252
is encoded by: hsa:1633
is: P27707
boundary condition: true
initial concentration: NaN
has only substance units: false
name: DCK
type: Species
constant: false
initial amount: NaN

metaM lac D e
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB01311
constant: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
is: CHEBI:16004
type: Species
name: (R)-lactate
is: SBO:0000247
has only substance units: false

metaM cytd e
is: HMDB00089
name: Cytidine
type: Species
is: C00475
initial amount: NaN
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
boundary condition: false
initial concentration: 1.0
is: CHEBI:17562
constant: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_09169369_ad63_4087_8991_110d6071fcf8
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:55191
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is: Q6IA69
type: Species
name: NADSYN1

metaR r0531
modifier: MODEL1310110025#
reversible: true
fast: false
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.34
name: dUTP:cytidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
kinetic law: MODEL1310110025#
type: Reaction
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:9923963 NOTES:
product: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_356babcf_2898_4a0e_9afc_ede48303d4c1
initial amount: NaN
is: SBO:0000252
name: _AA614647_1_c
is encoded by: hsa:AA614647
constant: false
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true

metaR r0644
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
is: SBO:0000176
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
product: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_0375361c_912d_4264_baec_b0bd8e35cb48
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AI990637
name: _AI990637_1_x
initial amount: NaN
constant: false

metaM CE2420 m
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
boundary condition: false
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
is: HMDB11123
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:28387
type: Species
is: SBO:0000247

metaR EX mercplaccys LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-mercaptolactate-cysteine disulfide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_141a2c86_a74d_4794_848a_6a0c94bb8d5a
is: SBO:0000252
is: Q9Y217
initial concentration: NaN
type: Species
name: MTMR6
initial amount: NaN
is encoded by: hsa:9107
has only substance units: false
boundary condition: true
constant: false

metaM dttp n
is: HMDB01342
constant: false
is: C00459
type: Species
initial amount: NaN
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: SBO:0000247
boundary condition: false
is: CHEBI:37568
has only substance units: false
name: dTTP
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110025#_d1b1d737_69f9_4bb1_9067_5b27cbb2f602
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: PEMT
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:10400
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_0922baeb_2cea_4929_99b1_6faedf3591d5
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: P21912
is encoded by: hsa:6390
name: SDHB
boundary condition: true
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_1df7f6ee_dd67_4240_9f68_5c369cd4e066
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: TPI1P2
is encoded by: hsa:286016
constant: false
has only substance units: false

metaR r0946
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110025#
is: SBO:0000185
kinetic law: MODEL1310110025#
type: Reaction
reversible: true
product: MODEL1310110025#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaM guln c
type: Species
boundary condition: false
initial concentration: 1.0
name: L-gulonate
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
is: CHEBI:13115
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB03290

http://identifiers.org/biomodels.db/MODEL1310110025#_6d5c2860_3ddd_49fd_a621_fe79b52c9fea
boundary condition: true
is encoded by: hsa:23169
initial amount: NaN
has only substance units: false
name: SLC35D1
initial concentration: NaN
is: Q9NTN3
type: Species
constant: false
is: SBO:0000252

metaM e4p c
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:16897
is: C00279
constant: false
name: D-Erythrose 4-phosphate
boundary condition: false
is: HMDB01321

metaM uacgam r
initial amount: NaN
is: CHEBI:57705
initial concentration: 1.0
is: HMDB00290
is: SBO:0000247
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
constant: false
has only substance units: false
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_8e0c0183_a238_4438_a929_98b7ea55b248
name: FASN
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: P49327
is encoded by: hsa:2194
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_0a790642_6651_4f27_8d59_6f2db2c20d00
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:1743
initial concentration: NaN
is: SBO:0000252
name: DLST
is: P36957
constant: false
boundary condition: true

metaR RE1532M
fast: false
name: RE1532
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110025#
type: Reaction
reversible: true
modifier: MODEL1310110025#
is: SBO:0000176
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_a2e78263_3646_4b70_ac39_d74882011f86
boundary condition: true
initial concentration: NaN
name: GGT2
has only substance units: false
initial amount: NaN
is encoded by: hsa:728441
constant: false
type: Species
is: SBO:0000252

metaM hmgcoa c
initial concentration: 1.0
has only substance units: false
is: CHEBI:15467
type: Species
constant: false
is: HMDB01375
boundary condition: false
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
is: SBO:0000247
name: Hydroxymethylglutaryl-CoA
initial amount: NaN

metaR VALtec
fast: false
product: MODEL1310110025#
reversible: true
name: L-valine transport via diffusion (extracellular to cytosol)
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
modifier: MODEL1310110025#
reactant: MODEL1310110025#

metaR AHC
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (191.1) or (10768.2) or (10768.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 3.3.1.1 Confidence Level: 4 AUTHORS: PMID:12590576,PMID:2596825 NOTES:
is: SBO:0000176
type: Reaction
reversible: true
name: adenosylhomocysteinase
modifier: MODEL1310110025#
reactant: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/3.3.1.1

metaM glyald m
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
name: D-glyceraldehyde
type: Species
is: CHEBI:17378
has only substance units: false
is: HMDB01051
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false

metaM maltttr e
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB01296
name: Maltotetraose
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052
is: http://identifiers.org/pubchem.compound/5141
initial amount: NaN
is: C02052

http://identifiers.org/biomodels.db/MODEL1310110025#_36febdbc_5adc_4e7a_8734_365bb8a3b784
is: Q53TV9
name: RPE
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6120
constant: false

metaR r1818
reversible: false
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110025#
product: MODEL1310110025#
modifier: MODEL1310110025#
reactant: MODEL1310110025#

metaR RE3326M
fast: false
is version of: http://identifiers.org/ec-code/1.2.4.4
modifier: MODEL1310110025#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110025#
type: Reaction
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:2699399,PMID:9665099 NOTES:
is: SBO:0000176
reactant: MODEL1310110025#
name: RE3326

metaM HC00664 c
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-2-6(10)5(9)4(8)3(15-6)1-14-16(11,12)13/h3-5,7-10H,1-2H2,(H2,11,12,13)/p-2/t3-,4+,5+,6?/m1/s1 EHMN_ABBREVIATION: C01097
constant: false
initial concentration: 1.0
is: CHEBI:58695
name: D-tagatofuranose 6-phosphate(2-)
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species

metaR r1604
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110025#
reversible: true
reactant: MODEL1310110025#
type: Reaction

metaR ALAGLNexR
fast: false
name: L-alanine/glutamine reversible exchange
type: Reaction
kinetic law: MODEL1310110025#
is: SBO:0000185
product: MODEL1310110025#
is described by: ECO:0000304
reactant: MODEL1310110025#
reversible: true
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

metaM accoa x
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: HMDB01206
is: C00024
boundary condition: false
type: Species
name: Acetyl-CoA
is: CHEBI:57288
has only substance units: false

metaM udpglcur r
is: HMDB00935
type: Species
has only substance units: false
name: UDP-D-glucuronate
boundary condition: false
is: C00167
initial concentration: 1.0
constant: false
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
initial amount: NaN
is: CHEBI:58052
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110025#_168c9474_211d_419c_a591_1b43c0c92335
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
is: Q9BZQ4
has only substance units: false
boundary condition: true
is encoded by: hsa:23057
initial concentration: NaN
name: NMNAT2

http://identifiers.org/biomodels.db/MODEL1310110025#_d93222b9_5722_40d7_88f1_7ea90dad3dec
is: P30613
is encoded by: hsa:5313
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
name: PKLR
has only substance units: false

metaM psylchol e
name: psillium-glycocholic acid complex
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C9642032H15428743NO8667420 CHARGE: 0
is: CHEBI:57449
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110025#_ccdb30f5_acae_4124_89c5_2798fff252a9
type: Species
constant: false
initial concentration: NaN
is: Q5JPA4
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:53919
has only substance units: false
name: SLCO1C1

metaR ORNt3m
kinetic law: MODEL1310110025#
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
fast: false
name: ornithine mitochondrial transport via proton antiport
reversible: true
product: MODEL1310110025#
reactant: MODEL1310110025#
modifier: MODEL1310110025#
type: Reaction

metaR AMETtd
fast: false
product: MODEL1310110025#
is: SBO:0000185
reactant: MODEL1310110025#
type: Reaction
is described by: ECO:0000134
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: diffusion of S-Adenosyl-L-methionine
kinetic law: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_83fa1247_3517_491c_b6f4_69dc1d74ac34
is: Q16853
name: AOC3
is encoded by: hsa:8639
type: Species
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR ALDD2xm
modifier: MODEL1310110025#
product: MODEL1310110025#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (219.1) or (217.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:18983992,PMID:18983993,PMID:19382904,PMID:19382905 NOTES:NCD. For NAD
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000134
name: aldehyde dehydrogenase (acetylaldehyde, NAD), mitochondrial
kinetic law: MODEL1310110025#
reversible: false
reactant: MODEL1310110025#

metaR r1603
kinetic law: MODEL1310110025#
type: Reaction
reactant: MODEL1310110025#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
product: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

metaM Lpipecol x
notes: FORMULA: C6H11NO2 CHARGE: 0 INCHI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1 EHMN_ABBREVIATION: C00408
name: L-pipecolic acid
boundary condition: false
is: HMDB00716
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:30913

metaR r1817
is described by: ECO:0000000
fast: false
name: Y+LAT2 Utilized transport
product: MODEL1310110025#
reactant: MODEL1310110025#
type: Reaction
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
is: SBO:0000185
modifier: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_3efd7d18_4496_4f68_9906_4b2ad343a1f1
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:AI378339
name: _AI378339_1_m

metaR r1693
is: SBO:0000185
reversible: false
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110025#
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
name: Y+LAT2 Utilized transport
type: Reaction
reactant: MODEL1310110025#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110025#_429f704b_511e_4c8d_9053_5485dffa753c
is: P49914
name: MTHFS
initial concentration: NaN
has only substance units: false
is encoded by: hsa:10588
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
type: Species

metaM fadh2 m
initial amount: NaN
name: Flavin adenine dinucleotide reduced
is: CHEBI:58307
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
constant: false
type: Species
is: HMDB01197
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: C01352
has only substance units: false

metaR NDPK1m
is: SBO:0000176
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
reversible: true
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
is described by: ECO:0000254
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
product: MODEL1310110025#
type: Reaction

metaM strdnccoa m
is: SBO:0000247
constant: false
initial amount: NaN
is: C16163
has only substance units: false
is: HMDB06519
name: stearidonyl coenzyme A
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
is: http://identifiers.org/pubchem.compound/47205473

http://identifiers.org/biomodels.db/MODEL1310110025#_f0be88d2_8a2b_4b8c_862e_795443322d39
name: NDUFB9
is: Q9Y6M9
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:4715

metaR r1756
reactant: MODEL1310110025#
name: Y+LAT2 Utilized transport
type: Reaction
product: MODEL1310110025#
fast: false
modifier: MODEL1310110025#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110025#
reversible: false

metaR r2519
fast: false
name: Utilized transport
is: SBO:0000185
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110025#
reversible: true
kinetic law: MODEL1310110025#

metaR r1602
type: Reaction
product: MODEL1310110025#
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: true
reactant: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110025#_934bd02c_6576_44f0_8389_80a9fd802ad0
is encoded by: hsa:28976
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: ACAD9
type: Species
constant: false
has only substance units: false
is: Q9H845
initial amount: NaN

metaR RE0926E
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/3.2.1.1
name: RE0926
kinetic law: MODEL1310110025#
product: MODEL1310110025#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.17
reactant: MODEL1310110025#
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110025#_90321a1b_5b4c_47d8_b83f_528e9cfc29e2
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is: Q9HAS3
constant: false
name: SLC28A3
has only substance units: false
is encoded by: hsa:64078

http://identifiers.org/biomodels.db/MODEL1310110025#_d17554fa_aa67_4eb7_88f7_0710cbce9fb1
type: Species
is: P27708
has only substance units: false
is encoded by: hsa:790
name: CAD
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaR URIDK2m
name: uridylate kinase (dUMP), mitochondrial
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:IT
type: Reaction
is: SBO:0000176
reactant: MODEL1310110025#
is described by: ECO:0000134
fast: false
product: MODEL1310110025#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110025#_b075910c_7428_48f1_8ea4_16112d5cddfc
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:3615
initial amount: NaN
initial concentration: NaN
name: IMPDH2
is: P12268
constant: false

metaM udpacgal c
is: HMDB00304
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57847
is: SBO:0000247
name: UDP-N-acetyl-D-galactosamine(2-)
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
type: Species

metaM gsn c
type: Species
has only substance units: false
is: CHEBI:16750
is: C00387
name: Guanosine
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB00133

http://identifiers.org/biomodels.db/MODEL1310110025#_fbfb1fa8_4afb_4e47_a91e_d892aa9e671b
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:978
boundary condition: true
name: CDA
initial concentration: NaN
initial amount: NaN
is: P32320
constant: false

metaR GLYCTDle
name: difussion of glycerol accross the brush border membrane
is described by: ECO:0000134
reactant: MODEL1310110025#
fast: false
kinetic law: MODEL1310110025#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
product: MODEL1310110025#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_ca7cdcaf_87d2_412c_a6b6_e7b21a7a5cfe
is: Q9H2F3
is: SBO:0000252
is encoded by: hsa:80270
constant: false
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: HSD3B7

metaR GMPR
modifier: MODEL1310110025#
name: GMP reductase
notes: GENE_ASSOCIATION: (2766.1) or (51292.1) or (51292.3) or (51292.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.1.7 Confidence Level: 4 AUTHORS: PMID:12009299,PMID:8188226 NOTES:
type: Reaction
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.7.1.7
is: SBO:0000176
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
reversible: false
product: MODEL1310110025#

metaR EX cholate LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholate
type: Reaction

metaM thf m
boundary condition: false
is: C00101
constant: false
initial amount: NaN
is: SBO:0000247
name: 5,6,7,8-Tetrahydrofolate
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB01846
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
is: CHEBI:57453

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

metaM amp e
boundary condition: false
name: AMP
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: C00020
is: CHEBI:456215
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB00045
constant: false

metaR RE1796M
product: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.145
name: RE1796

metaM pail5p hs n
constant: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
has only substance units: false
is: CHEBI:57795
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110025#_7e339c7d_a648_4f6f_954e_407efca0dfb1
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:4704
name: NDUFA9
initial amount: NaN
is: Q16795
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_4e232c47_e8bc_47f1_ba94_13515a9197c1
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: Q8N370
name: SLC43A2
initial concentration: NaN
is encoded by: hsa:124935

http://identifiers.org/biomodels.db/MODEL1310110025#_6794acef_8b84_487c_bc3e_e9300c46e176
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
is: Q02338
is encoded by: hsa:622
name: BDH1
initial amount: NaN
has only substance units: false

metaR PHEACGLNt
reactant: MODEL1310110025#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14681857 NOTES:SAB
type: Reaction
is: SBO:0000185
name: PHEACGLN extracellular transport via diffusion
reversible: true
product: MODEL1310110025#
kinetic law: MODEL1310110025#

metaR MI1PP
name: myo-inositol 1-phosphatase
product: MODEL1310110025#
modifier: MODEL1310110025#
reversible: false
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
is described by: ECO:0000269
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/3.1.3.25
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110025#

metaR ACNAMtn
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110025#
product: MODEL1310110025#
type: Reaction
name: N-acetylneuraminate nuclear import
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110025#_16b6792e_2836_46de_ba4a_9e1dbaafcd89
is encoded by: hsa:27068
boundary condition: true
constant: false
name: PPA2
is: F8WDN9
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR Htr
reactant: MODEL1310110025#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is described by: ECO:0000000
type: Reaction
product: MODEL1310110025#
name: H transporter, endoplasmic reticulum
is: SBO:0000185
kinetic law: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_d58ecacd_c4e8_43f4_9c4c_27e6e7d96087
name: CEPT1
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:10390
is: B3KN25
is: SBO:0000252
constant: false

metaM cspg a e
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
initial amount: NaN
is: HMDB00630
has only substance units: false
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
is: CHEBI:16040
constant: false

metaR EX trp L LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tryptophan exchange
type: Reaction

metaM dcacoa x
constant: false
is: CHEBI:61430
name: Decanoyl-CoA (n-C10:0CoA)
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
boundary condition: false
has only substance units: false
initial amount: NaN
is: C05274
is: HMDB06404
is: SBO:0000247
type: Species
initial concentration: 1.0

metaM 2dr5p c
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
name: 2-deoxy-D-ribose 5-phosphate(2-)
is: CHEBI:57651
has only substance units: false
is: HMDB01031

metaR FAOXC2051843m
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of fatty acid
fast: false
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110025#
type: Reaction
product: MODEL1310110025#

metaR ARACHDtr
name: intracellular transport
product: MODEL1310110025#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
fast: false
is: SBO:0000185
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110025#_baab47fc_02a0_4047_ba28_fdf50df57c3d
is encoded by: hsa:3939
name: LDHA
is: P00338
is: SBO:0000252
constant: false
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaM hyptaur c
constant: false
initial amount: NaN
is: HMDB00965
is: CHEBI:16668
initial concentration: 1.0
has only substance units: false
name: Hypotaurine
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519

http://identifiers.org/biomodels.db/MODEL1310110025#_d0e89b23_8005_4014_b6d1_79d79cf14cb1
has only substance units: false
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
name: PIGA
is encoded by: hsa:5277
is: P37287
boundary condition: true

metaR r1600
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reactant: MODEL1310110025#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaM L2aadp c
boundary condition: false
is: SBO:0000247
is: CHEBI:58672
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
initial concentration: 1.0
type: Species
is: HMDB00510
name: L-2-aminoadipate(1-)
constant: false
has only substance units: false
initial amount: NaN

metaR PTCRTD
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 9505881, PMID: 11564949 NOTES:putriscine uptake by the cells via passive diffusion, reported to be more rapid at the basolateral side.
reversible: true
type: Reaction
fast: false
name: diffusion of putriscine into the endothelial cells
is: SBO:0000185
is described by: ECO:0000134
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reactant: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_f27759bb_d98e_4540_b8a6_cec537270d4d
is encoded by: hsa:377841
initial concentration: NaN
boundary condition: true
name: ENTPD8
constant: false
is: SBO:0000252
is: Q5MY95
initial amount: NaN
type: Species
has only substance units: false

metaR r0638
fast: false
reactant: MODEL1310110025#
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is version of: http://identifiers.org/ec-code/2.8.1.2
kinetic law: MODEL1310110025#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110025#
reversible: true
is described by: ECO:0000000
product: MODEL1310110025#

metaR ACGALtly
reversible: false
is: SBO:0000185
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110025#
name: N-acetyl-galactosamine lysosomal efflux
kinetic law: MODEL1310110025#
fast: false

metaM CE1926 e
type: Species
is: HMDB00127
is: SBO:0000247
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926
initial concentration: 1.0
name: gama-carboxyethyl-hydroxychroman
is: CHEBI:15748
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false

metaM acnam n
is: SBO:0000247
name: N-acetylneuraminate
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
is: HMDB00230
is: CHEBI:35418
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaM ethamp c
is: SBO:0000247
type: Species
is: HMDB00224
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
name: ethamp[c]
is: CHEBI:58190

metaR ME1m
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.1.1.38
notes: GENE_ASSOCIATION: (4200.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
fast: false
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110025#
type: Reaction
reactant: MODEL1310110025#
product: MODEL1310110025#
name: malic enzyme (NAD), mitochondrial

metaM ctp e
boundary condition: false
is: HMDB00082
type: Species
is: CHEBI:37563
initial concentration: 1.0
name: CTP(4-)
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_8cbfa4ad_f9fd_4a1d_a4b9_a7aad47a8853
constant: false
initial amount: NaN
name: LDHA
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:3939
has only substance units: false
is: P00338

metaM dttp c
is: CHEBI:37568
boundary condition: false
is: HMDB01342
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
is: C00459
name: dTTP

http://identifiers.org/biomodels.db/MODEL1310110025#_f9ec519e_bc47_4ab0_9fe8_12b6e034cf76
type: Species
boundary condition: true
name: _AI373818_1_m
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI373818
is: SBO:0000252
constant: false
initial amount: NaN

metaR r0639
is described by: ECO:0000000
reversible: false
name: Lauroyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reactant: MODEL1310110025#
product: MODEL1310110025#
fast: false
is: SBO:0000176
type: Reaction

metaM dadp c
boundary condition: false
type: Species
initial amount: NaN
is: C00206
has only substance units: false
is: HMDB01508
is: CHEBI:57667
constant: false
name: dADP
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206

http://identifiers.org/biomodels.db/MODEL1310110025#_ca41e454_0766_4653_9d3d_a567a2e23ed9
name: SMS
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:6611
initial concentration: NaN
type: Species
is: P52788
initial amount: NaN
has only substance units: false

metaM 2mcit e
is: CHEBI:15598
has only substance units: false
type: Species
is: HMDB00379
name: 2-methylcitrate(3-)
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C7H7O7 CHARGE: -3 INCHI: InChI=1S/C7H10O7/c1-3(5(10)11)7(14,6(12)13)2-4(8)9/h3,14H,2H2,1H3,(H,8,9)(H,10,11)(H,12,13)/p-3
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110025#_9db961b2_e739_423b_b3ab_e53a7807bc93
is: SBO:0000252
has only substance units: false
name: GCDH
constant: false
initial concentration: NaN
is encoded by: hsa:2639
boundary condition: true
initial amount: NaN
type: Species

metaR 3MOBt2im
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
name: 3-methyl-2-oxobutanoate mitochondrial transport via proton symport
reversible: false
fast: false
product: MODEL1310110025#
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
is: SBO:0000185
type: Reaction

metaR GPIAT
fast: false
product: MODEL1310110025#
name: glucosaminylphosphatidyl inositol acetyltransferase
kinetic law: MODEL1310110025#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (284098.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14517336 NOTES:EC 2.3.-.- NCD
type: Reaction
modifier: MODEL1310110025#
reactant: MODEL1310110025#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110025#_de113b8a_4e8b_40a7_8ed9_0a277819b4ea
constant: false
type: Species
is encoded by: hsa:112
is: O43306
name: ADCY6
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR GGH 7THFe
reversible: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is version of: http://identifiers.org/ec-code/3.4.19.9
modifier: MODEL1310110025#
fast: false
product: MODEL1310110025#
is described by: ECO:0000000
kinetic law: MODEL1310110025#
name: Gamma-glutamyl hydrolase (7THF), extracellular
type: Reaction
is: SBO:0000176
reactant: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_338a211e_4290_40b1_9ca5_6396e8f8a869
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:224
has only substance units: false
constant: false
name: ALDH3A2
is: P51648
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110025#_7cdedff4_221c_49a1_9afc_760fd19c8d33
constant: false
name: ADCY10
is: F5GWS5
initial concentration: NaN
is encoded by: hsa:55811
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false

metaR DNDPt24m
modifier: MODEL1310110025#
type: Reaction
kinetic law: MODEL1310110025#
is: SBO:0000185
fast: false
is described by: ECO:0000269
reactant: MODEL1310110025#
name: dTDP transport via dADP antiport
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110025#

metaM ps hs m
constant: false
is: CHEBI:18303
initial concentration: 1.0
name: ps_hs[m]
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_2f4d4ae7_bef0_4692_a9e2_9230208f707f
is: P55084
constant: false
type: Species
boundary condition: true
is encoded by: hsa:3032
initial amount: NaN
name: HADHB
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR SUCD1m
reactant: MODEL1310110025#
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110025#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.5.1
modifier: MODEL1310110025#
product: MODEL1310110025#
reversible: true
name: succinate dehydrogenase

http://identifiers.org/biomodels.db/MODEL1310110025#_2ffe2bd0_3316_4530_a9fc_e4570a2289e1
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
is encoded by: hsa:5277
constant: false
has part: P37287
initial amount: NaN
is: SBO:0000297
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:8818

metaM dttp e
is: HMDB01342
has only substance units: false
name: dTTP(4-)
initial amount: NaN
is: CHEBI:37568
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
is: SBO:0000247

metaR DM fol
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for folic aicd
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_17900a84_5be6_4201_ae8a_f987f3df515a
initial concentration: NaN
has only substance units: false
is: O75355
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:956
constant: false
name: ENTPD3
boundary condition: true

metaM ctp c
has only substance units: false
name: CTP
initial concentration: 1.0
is: CHEBI:37563
initial amount: NaN
is: HMDB00082
boundary condition: false
is: SBO:0000247
is: C00063
type: Species
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_3d78fae1_afde_440e_8681_b0cdfa10a4fb
type: Species
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:7371
is: SBO:0000252
initial concentration: NaN
name: UCK2
is: Q9BZX2
boundary condition: true

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

metaR P450SCC1m
reversible: true
fast: false
reactant: MODEL1310110025#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
is described by: ECO:0000134
product: MODEL1310110025#
name: cholesterol monooxygenase
kinetic law: MODEL1310110025#
type: Reaction

metaR SUCCt2m
reversible: true
is: SBO:0000185
product: MODEL1310110025#
modifier: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000269
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
fast: false
name: succinate transport, mitochondrial
type: Reaction

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

metaR EX co LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Carbon monoxide exchange
type: Reaction

metaM malthx e
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: C01936
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
boundary condition: false
name: Maltohexaose
is: http://identifiers.org/pubchem.compound/5041
constant: false
initial concentration: 1.0

metaR ACGPID
kinetic law: MODEL1310110025#
is described by: ECO:0000269
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.5.1.89
reactant: MODEL1310110025#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (9487.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.5.1.89 Confidence Level: 4 AUTHORS: PMID:10085243,PMID:14742432 NOTES:NCD
name: N-acetylglucosaminylphosphatidylinositol deacetylase
product: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_4229576d_9a09_4a27_8a33_85509aea5e84
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:56894
name: AGPAT3
boundary condition: true
type: Species
is: SBO:0000252

metaM 2mcit c
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB00379
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C7H7O7 CHARGE: -3 INCHI: InChI=1S/C7H10O7/c1-3(5(10)11)7(14,6(12)13)2-4(8)9/h3,14H,2H2,1H3,(H,8,9)(H,10,11)(H,12,13)/p-3
name: 2-methylcitrate(3-)
is: CHEBI:15598
constant: false

metaM 5thf e
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB06487
name: pentaglutamyl folate (THF)
notes: FORMULA: C39H45N11O18 CHARGE: -6
initial amount: NaN
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_ca1ddef0_f4cd_4091_8eda_77fb19c3d785
type: Species
initial concentration: NaN
has only substance units: false
is: Q9H008
is: SBO:0000252
name: LHPP
constant: false
boundary condition: true
is encoded by: hsa:64077
initial amount: NaN

metaM 5mta c
is: CHEBI:17509
is: HMDB01173
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C11H15N5O3S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00165 EHMN_ABBREVIATION: C00170
boundary condition: false
constant: false
is: C00170
initial concentration: 1.0
name: 5-Methylthioadenosine

metaR RE2349C
reversible: true
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES:IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C
type: Reaction
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.6.1.64
is described by: ECO:0000000
product: MODEL1310110025#
name: RE2349
reactant: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_09bf9390_d9d6_4ed6_ad61_09cc71363fb6
boundary condition: true
is encoded by: hsa:5151
name: PDE8A
constant: false
is: H0YMZ7
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaM HC01407 m
boundary condition: false
name: (S)-Hydroxyhexanoyl-CoA
is: CHEBI:28276
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268
initial concentration: 1.0
is: SBO:0000247
constant: false

metaM acac m
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
type: Species
constant: false
is: CHEBI:13705
is: HMDB00060
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: acetoacetate
initial concentration: 1.0
has only substance units: false

metaM trdox c
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
name: Oxidized thioredoxin
is: CHEBI:18191
is: C00343
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343

http://identifiers.org/biomodels.db/MODEL1310110025#_bd3b26cb_e754_4f68_8002_dbbee19194b1
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
name: COX7B2
initial amount: NaN
has only substance units: false
is: Q8TF08
is encoded by: hsa:170712
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_cfd06fb3_e01e_4549_970b_016f69b15ee1
is encoded by: hsa:6584
is: SBO:0000252
initial amount: NaN
type: Species
is: O76082
constant: false
boundary condition: true
name: SLC22A5
initial concentration: NaN
has only substance units: false

metaR MI1PS
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/5.5.1.4
product: MODEL1310110025#
is described by: ECO:0000269
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
type: Reaction
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (51477.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 5.5.1.4 Confidence Level: 4 AUTHORS: PMID:12941308 NOTES:NCD
reversible: false
name: myo-Inositol-1-phosphate synthase

metaM hista c
initial concentration: 1.0
constant: false
is: HMDB00870
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
boundary condition: false
is: CHEBI:58432
name: histamium
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR RE2814R
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
product: MODEL1310110025#
reversible: true
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
name: RE2814
fast: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction

metaM dcacoa m
initial amount: NaN
is: HMDB06404
is: C05274
is: CHEBI:61430
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
name: Decanoyl-CoA (n-C10:0CoA)
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false

metaM Lkynr c
initial amount: NaN
name: L-kynurenine
boundary condition: false
is: HMDB00684
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
is: CHEBI:16946

http://identifiers.org/biomodels.db/MODEL1310110025#_32fe18dd_487b_4d3d_af37_8edee95410a4
is encoded by: hsa:5464
initial concentration: NaN
is: SBO:0000252
is: Q15181
constant: false
boundary condition: true
name: PPA1
has only substance units: false
initial amount: NaN
type: Species

metaM fadh2 r
name: FADH2(2-)
boundary condition: false
is: CHEBI:58307
is: SBO:0000247
has only substance units: false
is: HMDB01197
type: Species
initial concentration: 1.0
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_cfb15565_235b_4918_b124_44954be7d55b
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: ADH5
constant: false
is: Q6IRT1
is encoded by: hsa:128
type: Species
initial concentration: NaN
has only substance units: false

metaR r2511
type: Reaction
product: MODEL1310110025#
fast: false
kinetic law: MODEL1310110025#
reversible: true
is: SBO:0000185
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is described by: ECO:0000000
name: Utilized transport

metaR r0752
fast: false
reactant: MODEL1310110025#
reversible: true
kinetic law: MODEL1310110025#
is: SBO:0000176
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
is described by: ECO:0000000
product: MODEL1310110025#
modifier: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_7dda9b3b_7f59_459f_8673_74b29450e0b0
is: SBO:0000252
is encoded by: hsa:4200
type: Species
constant: false
boundary condition: true
initial amount: NaN
is: P23368
initial concentration: NaN
has only substance units: false
name: ME2

metaM accoa n
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
is: HMDB01206
initial amount: NaN
is: CHEBI:57288
initial concentration: 1.0
name: acetyl-CoA(4-)
constant: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024

metaR GCCam
is version of: http://identifiers.org/ec-code/1.4.4.2
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110025#
product: MODEL1310110025#
modifier: MODEL1310110025#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.2.10
reactant: MODEL1310110025#
name: glycine-cleavage complex (lipoylprotein), mitochondrial
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.4

metaM pmtcoa x
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
boundary condition: false
type: Species
is: C00154
is: CHEBI:57379
is: HMDB01338
has only substance units: false
initial amount: NaN
name: Palmitoyl-CoA (n-C16:0CoA)

metaR CYTK13
kinetic law: MODEL1310110025#
name: cytidylate kinase (dCMP,dATP)
reactant: MODEL1310110025#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
product: MODEL1310110025#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
is described by: ECO:0000269
modifier: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_0ca716a6_3672_452c_a62c_543ca6025a5b
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:53354
name: PANK1
boundary condition: true
constant: false
initial amount: NaN

metaM 5mta e
is: CHEBI:17509
is: HMDB01173
initial amount: NaN
notes: FORMULA: C11H15N5O3S CHARGE: 0
is: SBO:0000247
type: Species
constant: false
has only substance units: false
boundary condition: false
is: C00170
initial concentration: 1.0
name: 5-Methylthioadenosine

http://identifiers.org/biomodels.db/MODEL1310110025#_310587c8_d380_4260_92b0_f946266d5e99
is encoded by: hsa:51292
name: GMPR2
constant: false
is: Q9P2T1
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN

metaR r0753
is: SBO:0000176
product: MODEL1310110025#
fast: false
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:
type: Reaction
is described by: ECO:0000000
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110025#_f366cf77_c460_4c13_9412_4fecfc7b9baf
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:7108
is: SBO:0000252
is: O76062
name: TM7SF2
has only substance units: false

metaR Htx
name: H transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
type: Reaction
reactant: MODEL1310110025#
fast: false
kinetic law: MODEL1310110025#
product: MODEL1310110025#
is: SBO:0000185
reversible: true
is described by: ECO:0000000

metaR RE2649C
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.2.2
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.65
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
reactant: MODEL1310110025#
name: RE2649
modifier: MODEL1310110025#
product: MODEL1310110025#
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110025#_ffc288fb_53f0_412c_9b73_93d4c9b6bf7c
is encoded by: hsa:108
constant: false
type: Species
initial concentration: NaN
boundary condition: true
is: Q71UM8
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: ADCY2

metaM fol m
initial amount: NaN
initial concentration: 1.0
name: Folate
constant: false
is: SBO:0000247
is: CHEBI:27470
has only substance units: false
type: Species
boundary condition: false
is: HMDB00121
notes: FORMULA: C19H18N7O6 CHARGE: -1 INCHI: InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00396 EHMN_ABBREVIATION: C00504

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

metaM 3hmp m
has only substance units: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
initial amount: NaN
is: SBO:0000247
name: 3-hydroxy-2-methylpropanoate
constant: false
initial concentration: 1.0
type: Species
is: HMDB00023
boundary condition: false
is: CHEBI:11805

metaM cit m
initial concentration: 1.0
is: CHEBI:16947
is: SBO:0000247
initial amount: NaN
is: C00158
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
type: Species
constant: false
is: HMDB00094
name: Citrate
boundary condition: false
has only substance units: false

metaR TPI
modifier: MODEL1310110025#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/5.3.1.1
kinetic law: MODEL1310110025#
is described by: ECO:0000134
name: triose-phosphate isomerase
reactant: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
is: SBO:0000176
product: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_24a3f57a_6ea2_4579_8ee4_619ced7be039
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:27068
initial amount: NaN
is: Q9H2U2
name: PPA2
initial concentration: NaN
constant: false
type: Species

metaM HC01496 m
constant: false
initial concentration: 1.0
name: 2-Amino-3-oxoadipate
has only substance units: false
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
initial amount: NaN
boundary condition: false
is: CHEBI:28095
type: Species
is: SBO:0000247

metaR ACACt2m
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
product: MODEL1310110025#
fast: false
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000269
name: Acetoacetate mitochondrial transport via H+ symport

metaR RE3050R
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215 NOTES:
name: RE3050
reversible: true
type: Reaction
reactant: MODEL1310110025#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110025#
is described by: ECO:0000000

metaR IDOURte
fast: false
is: SBO:0000185
name: L-iduronate transport, extracellular
kinetic law: MODEL1310110025#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
reactant: MODEL1310110025#
product: MODEL1310110025#
type: Reaction

metaR CYTK14
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110025#
type: Reaction
is described by: ECO:0000269
name: cytidylate kinase (dCMP,UTP)
is: SBO:0000176
reversible: true
reactant: MODEL1310110025#

metaR r0157
fast: false
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
kinetic law: MODEL1310110025#
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110025#
product: MODEL1310110025#
reactant: MODEL1310110025#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
is version of: http://identifiers.org/ec-code/6.3.4.2
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_da879e31_af37_41a8_a7fb_5d1bda2bc514
type: Species
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: FOLR1
is encoded by: hsa:2348
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110025#_c641d812_fc76_4604_a264_950db80eb88f
is encoded by: hsa:8879
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
name: SGPL1
initial amount: NaN
is: O95470
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_dd1086c5_a577_4eff_9f4d_ea0ed6a461c8
is encoded by: hsa:641371
name: ACOT1
boundary condition: true
initial amount: NaN
type: Species
is: E9KL42
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN

metaR DURIK1
reversible: false
name: deoxyuridine kinase (ATP:Deoxyuridine)
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.7.1.21
fast: false
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (7083.1) or (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 2 AUTHORS: PMID:12535661,PMID:9342341 NOTES:
reactant: MODEL1310110025#
type: Reaction
product: MODEL1310110025#
modifier: MODEL1310110025#
is: SBO:0000176

metaR CYTK7n
reactant: MODEL1310110025#
name: cytidylate kinase (CMP,UTP),nuclear
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
kinetic law: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110025#

metaR DNDPt4m
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
product: MODEL1310110025#
kinetic law: MODEL1310110025#
name: dATP transport via dUDP antiport
fast: false
reactant: MODEL1310110025#
modifier: MODEL1310110025#
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

metaR r2051
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
is: SBO:0000185
reversible: false
type: Reaction
reactant: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_3fa9495d_5987_44d2_9fc2_0340e22be88e
constant: false
name: PIGX
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:54965
is: Q8TBF5

metaR CYTK11
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
type: Reaction
fast: false
modifier: MODEL1310110025#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
name: cytidylate kinase (dCMP,dGTP)
product: MODEL1310110025#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM andrstrn r
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:16032
is: HMDB00031
has only substance units: false
name: androsterone
boundary condition: false
initial amount: NaN
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523

http://identifiers.org/biomodels.db/MODEL1310110025#_7e79d8bb_1298_4b21_bf93_5977163ff9b4
is: B2RBR4
name: SLC20A2
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:6575
has only substance units: false
boundary condition: true

metaR RE1519M
modifier: MODEL1310110025#
reactant: MODEL1310110025#
name: RE1519
is version of: http://identifiers.org/ec-code/1.3.99.13
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
fast: false
product: MODEL1310110025#
type: Reaction

metaR RE2814M
name: RE2814
reactant: MODEL1310110025#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
kinetic law: MODEL1310110025#
product: MODEL1310110025#
fast: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction

metaM ctp m
is: HMDB00082
boundary condition: false
type: Species
constant: false
is: CHEBI:37563
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: SBO:0000247
initial concentration: 1.0
name: CTP(4-)
has only substance units: false
initial amount: NaN

metaR r0407
modifier: MODEL1310110025#
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
is version of: http://identifiers.org/ec-code/1.4.3.5
fast: false
is: SBO:0000176
reactant: MODEL1310110025#
type: Reaction
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
reversible: true
kinetic law: MODEL1310110025#
is described by: ECO:0000000

metaM accoa m
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:57288
is: C00024
is: HMDB01206
type: Species
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
initial amount: NaN
name: Acetyl-CoA
boundary condition: false

metaR r0156
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
kinetic law: MODEL1310110025#
reversible: false
type: Reaction
product: MODEL1310110025#
reactant: MODEL1310110025#
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
is described by: ECO:0000000
modifier: MODEL1310110025#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.40
is: SBO:0000176

metaR DHCR71r
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.3.1.21
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:9465114 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110025#
reversible: false
name: 7-dehydrocholesterol reductase
reactant: MODEL1310110025#

metaM amp c
name: AMP
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C10H12N5O7P CHARGE: -2
is: CHEBI:3322
is: SBO:0000247
has only substance units: false
is: HMDB00045
boundary condition: false
initial amount: NaN
is: C00020

metaR CYSGLYexR
kinetic law: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
modifier: MODEL1310110025#
type: Reaction
name: L-cysteine/glycine reversible exchanger
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110025#
reversible: true

metaR ACt2m
fast: false
is: SBO:0000185
reactant: MODEL1310110025#
type: Reaction
name: acetate mitochondrial transport via proton symport
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110025#_82574323_a4a4_491c_bc54_3139e25a5ede
is: SBO:0000252
name: _AL048840_1_c
has only substance units: false
initial amount: NaN
is encoded by: hsa:AL048840
type: Species
boundary condition: true
constant: false
initial concentration: NaN

metaR VD3
fast: false
name: Vitamin D3 formation
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8392061 NOTES:This reaction takes place in skin and needs body temperature based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
is: SBO:0000176
reversible: true
is described by: ECO:0000134
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_df8e2836_017f_4ae9_a424_8e6de5457a7d
boundary condition: true
constant: false
is: P31040
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6389
type: Species
initial amount: NaN
name: SDHA
has only substance units: false

metaM xylt c
name: xylitol
is: HMDB02917
type: Species
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
has only substance units: false
initial amount: NaN
is: CHEBI:17151
initial concentration: 1.0

metaR AMPtp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ
reversible: true
name: AMP transporter, peroxisome
reactant: MODEL1310110025#
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110025#
product: MODEL1310110025#
is: SBO:0000185

metaM prostgh2 e
is: HMDB01381
constant: false
name: prostaglandin H2(1-)
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:57405
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
type: Species

metaR r2052
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
product: MODEL1310110025#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
is: SBO:0000185
modifier: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_20bed4a8_47ae_4a8e_838d_f5915527209c
type: Species
boundary condition: true
initial concentration: NaN
is: Q59EH3
is: SBO:0000252
has only substance units: false
name: ACP1
initial amount: NaN
constant: false
is encoded by: hsa:52

http://identifiers.org/biomodels.db/MODEL1310110025#_062d8c6e_eef4_4b15_ac62_cb035e0858a6
type: Species
constant: false
is encoded by: hsa:6526
has only substance units: false
boundary condition: true
initial concentration: NaN
is: P53794
is: SBO:0000252
initial amount: NaN
name: SLC5A3

metaR NMNATr
is: SBO:0000176
product: MODEL1310110025#
modifier: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.7.1
type: Reaction
name: nicotinamide-nucleotide adenylyltransferase
reversible: true
kinetic law: MODEL1310110025#
fast: false
is described by: ECO:0000269

metaR CYTK12
kinetic law: MODEL1310110025#
product: MODEL1310110025#
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
fast: false
is: SBO:0000176
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110025#
name: cytidylate kinase (dCMP,dCTP)

metaR EX dag hs LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for diglyceride
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_2b8417c8_087b_4572_83ed_f4cf708fdc67
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
name: PLD1
is: Q59EA4
is encoded by: hsa:5337

metaM pglyc hs c
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:60523
has only substance units: false
type: Species
boundary condition: false
name: phosphatidylglycerol(1-)
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096

http://identifiers.org/biomodels.db/MODEL1310110025#_f1e3b7f5_b60e_42a9_87f5_e581ed374ab1
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

metaM ctp n
type: Species
constant: false
is: SBO:0000247
name: CTP(4-)
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:37563
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: HMDB00082
initial concentration: 1.0

metaR r0408
is described by: ECO:0000000
fast: false
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
reversible: true
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
modifier: MODEL1310110025#
product: MODEL1310110025#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.5
type: Reaction
kinetic law: MODEL1310110025#

metaM 10fthf6glu e
is: CHEBI:57454
boundary condition: false
is: HMDB00972
has only substance units: false
name: 10-formyltetrahydrofolate-[Glu](6)
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_3f0a24c9_480f_4745_8281_412139578a12
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: P49619
name: DGKG
has only substance units: false
type: Species
is encoded by: hsa:1608

metaM ps hs c
has only substance units: false
type: Species
is: CHEBI:18303
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
name: ps_hs[c]
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaM HC00591 c
name: 2-oxoglutaramate
is: CHEBI:16769
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940

metaM C04849 e
initial amount: NaN
is: CHEBI:57449
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
is: SBO:0000247
constant: false
has only substance units: false

metaR GUAt
modifier: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR
name: Guanine transport
reversible: true
kinetic law: MODEL1310110025#
is: SBO:0000185
fast: false
reactant: MODEL1310110025#
type: Reaction
is described by: ECO:0000269

metaM 3mb2coa m
name: 3-methylbut-2-enoyl-CoA(4-)
is: CHEBI:57344
is: SBO:0000247
type: Species
is: HMDB01493
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110025#_b78230e6_afdb_4f6f_a200_7dc5b4d401b1
type: Species
boundary condition: true
is encoded by: hsa:3101
constant: false
is: P52790
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: HK3

metaR GLYCt
type: Reaction
name: glycerol transport via channel
is: SBO:0000185
kinetic law: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
reversible: true
is described by: ECO:0000000
fast: false
reactant: MODEL1310110025#

metaM trdrd m
has only substance units: false
name: Reduced thioredoxin
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15967
initial amount: NaN
type: Species
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110025#_62c47a7c_e8e5_475e_993d_9e5c347ac0b6
is: SBO:0000252
name: PPT1
is: Q6FGQ4
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
constant: false
boundary condition: true
is encoded by: hsa:5538

http://identifiers.org/biomodels.db/MODEL1310110025#_57c5b84d_3372_429c_8fb2_9b9a807938a0
name: NDUFA12
is: F8VQS7
is: SBO:0000252
is encoded by: hsa:55967
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
type: Species

metaM alpro m
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:16882
boundary condition: false
has only substance units: false
name: S-Aminomethyldihydrolipoylprotein
initial amount: NaN
notes: FORMULA: CH6NS2X CHARGE: 1 EHMN_ABBREVIATION: C01242

metaM dlnlcgcoa c
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
name: dihomo-gamma-linolenyl coenzyme A
is: CHEBI:27979
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110025#_b0cf9061_e731_4210_ad94_8b1d0ecd902d
is: Q9Y666
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: SLC12A7
is: SBO:0000252
is encoded by: hsa:10723
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_294277a3_3750_4c53_9073_7aa1102f7be8
constant: false
is: Q92947
initial amount: NaN
name: GCDH
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2639
type: Species

metaR r1966
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110025#
is described by: ECO:0000000
fast: false
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_7fa7b570_d708_4804_bd2f_c7404bcb6704
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:728226
name: _728226_1_m

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_ad55f458_86a8_42d2_89f5_eca8ca8aeadc
type: Species
boundary condition: true
has only substance units: false
is: Q9ULD0
initial amount: NaN
is encoded by: hsa:55753
constant: false
initial concentration: NaN
name: OGDHL
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110025#_94ba40d8_f041_43a6_a321_7d1e2c360562
initial amount: NaN
type: Species
is encoded by: hsa:6570
is: SBO:0000252
boundary condition: true
is: Q96GL6
has only substance units: false
name: SLC18A1
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_ab10bc96_be3c_49c5_bbae_2dc8f9e350e6
type: Species
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4357
name: MPST
is: P25325
boundary condition: true

metaM icit m
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
type: Species
is: HMDB00193
initial concentration: 1.0
is: SBO:0000247
constant: false
name: Isocitrate
initial amount: NaN
boundary condition: false
is: CHEBI:16087
has only substance units: false
is: C00311

metaM xylt e
initial concentration: 1.0
name: xylitol
constant: false
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
is: CHEBI:17151
has only substance units: false
is: HMDB02917

http://identifiers.org/biomodels.db/MODEL1310110025#_1380c552_5413_451e_9863_dcb720039a31
type: Species
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:162466
initial concentration: NaN
initial amount: NaN
name: PHOSPHO1
is: Q8TCT1
has only substance units: false

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

metaM mem2emgacpail prot hs r
is: CHEBI:58190
notes: FORMULA: C59H110N3O40P3FULLRCO2FULLR2CO2X CHARGE: 0
is: SBO:0000247
is: HMDB00224
initial amount: NaN
name: ({[(mannosyl),(phosphoethanolaminyl)]-dimannosyl},{phosphoethanolaminyl})-mannosyl-glucosaminyl-acylphosphatidylinositol-Protein (M4B)
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
has only substance units: false

metaM hista e
is: SBO:0000247
boundary condition: false
is: CHEBI:58432
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
is: HMDB00870
type: Species
name: histamium

metaR PGLYCt
type: Reaction
kinetic law: MODEL1310110025#
is described by: ECO:0000269
is: SBO:0000185
reversible: true
product: MODEL1310110025#
reactant: MODEL1310110025#
name: phosphatidylglycerol transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 3.1.3.18 Confidence Level: 2 AUTHORS: PMID:2164460,PMID:6290284 NOTES:

metaM HC02121 c
is: CHEBI:58758
constant: false
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180
name: S-(hydroxymethyl)glutathione(1-)
initial concentration: 1.0

metaM ps hs e
type: Species
has only substance units: false
name: phosphatidylserine
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
constant: false
boundary condition: false
is: CHEBI:18303
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaM frdp c
initial amount: NaN
is: C00448
name: Farnesyl diphosphate
boundary condition: false
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: CHEBI:175763
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB00961
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_8fce48dd_856a_4968_a7a2_230a5832f316
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:BC005314
name: _BC005314_1_x

metaR CYTK10
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (CMP,dGTP)
is described by: ECO:0000269
product: MODEL1310110025#
type: Reaction
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
kinetic law: MODEL1310110025#
fast: false
reactant: MODEL1310110025#

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

metaM uacgam c
initial amount: NaN
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
type: Species
is: HMDB00290
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
is: CHEBI:57705
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaR r1819
is: SBO:0000185
kinetic law: MODEL1310110025#
is described by: ECO:0000000
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
type: Reaction
product: MODEL1310110025#
fast: false
modifier: MODEL1310110025#
name: Y+LAT2 Utilized transport

metaM pglyc hs e
initial amount: NaN
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
has only substance units: false
is: CHEBI:60523
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
name: phosphatidylglycerol(1-)
type: Species

metaR UDPGLCAter
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110025#
product: MODEL1310110025#
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
is described by: ECO:0000269
is: SBO:0000185

metaM L2aadp m
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
initial amount: NaN
constant: false
name: L-2-aminoadipate(1-)
boundary condition: false
has only substance units: false
is: CHEBI:58672
is: HMDB00510

http://identifiers.org/biomodels.db/MODEL1310110025#_021ae257_9966_4b49_b52c_a41a7816b1b9
boundary condition: true
constant: false
name: BDH1
has only substance units: false
initial concentration: NaN
is encoded by: hsa:622
is: SBO:0000252
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_2e4f8a2b_5f49_46a4_b784_e56661eb1077
type: Species
is encoded by: hsa:AF080579
boundary condition: true
has only substance units: false
is: SBO:0000252
name: _AF080579_1_c
constant: false
initial amount: NaN
initial concentration: NaN

metaM ser D e
initial concentration: 1.0
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
name: D-serine
is: HMDB03406
is: CHEBI:16523

http://identifiers.org/biomodels.db/MODEL1310110025#_bb36d66a_e410_407e_92a3_cd78f4262fbe
is: B7Z6M3
initial amount: NaN
boundary condition: true
type: Species
name: DGKZ
is encoded by: hsa:8525
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110025#_83702942_972f_462d_9f17_6050f89f61b3
initial amount: NaN
is: Q9NWW6
constant: false
name: NMRK1
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:54981
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_f3f8472a_0841_4f27_add1_2119758ad16d
is: SBO:0000252
constant: false
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
name: _AI926493_1_c
is encoded by: hsa:AI926493
initial amount: NaN

metaR NACHEX2ly
is described by: ECO:0000000
reversible: false
type: Reaction
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110025#
kinetic law: MODEL1310110025#
name: beta-N-acetylhexosaminidase, lysosomal
is: SBO:0000176
reactant: MODEL1310110025#

metaM ocdca c
name: stearate
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
constant: false
is: CHEBI:25629
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
is: HMDB00827
has only substance units: false

metaM xol7aone m
is: SBO:0000247
is: CHEBI:17899
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
name: 7alpha-hydroxycholest-4-en-3-one
initial amount: NaN
is: HMDB01993
boundary condition: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455

metaR r2014
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110025#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110025#
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_4ce4fed5_c0c7_4468_9a0b_73fb1d989956
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:NM 013421
name: _NM_013421_1_e
constant: false
initial concentration: NaN

metaM arg L c
constant: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
initial concentration: 1.0
boundary condition: false
name: L-argininium(1+)
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB00517
initial amount: NaN
is: CHEBI:32682

metaR r0580
reactant: MODEL1310110025#
reversible: true
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
is: SBO:0000176
type: Reaction
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.3.99.7
modifier: MODEL1310110025#
is described by: ECO:0000000
product: MODEL1310110025#
fast: false

metaR RDH3
type: Reaction
name: retinol dehydrogenase (11-cis,NADH)
modifier: MODEL1310110025#
reversible: true
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.1.1.315
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368 NOTES:IT
product: MODEL1310110025#
kinetic law: MODEL1310110025#
is described by: ECO:0000269

metaR r2319
kinetic law: MODEL1310110025#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
type: Reaction
reactant: MODEL1310110025#
product: MODEL1310110025#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR r1547
fast: false
product: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_7c6bc2f8_da05_4a9d_aa61_f16fb0c2db70
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
name: PIGA
is encoded by: hsa:5277
initial amount: NaN

metaR r0717
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is: SBO:0000176
fast: false
product: MODEL1310110025#
reactant: MODEL1310110025#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110025#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_1137e5a0_7b1d_4abd_8fde_eac033b9269c
has only substance units: false
is: O15382
is encoded by: hsa:587
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: BCAT2

http://identifiers.org/biomodels.db/MODEL1310110025#_1f9dd446_e55a_42b6_8a27_256adf113ffe
constant: false
is encoded by: hsa:10423
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: O14735
name: CDIPT
type: Species
initial amount: NaN
boundary condition: true

metaM ddsmsterol r
boundary condition: false
type: Species
has only substance units: false
is: HMDB03896
initial concentration: 1.0
name: 7-dehydrodesmosterol
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9-10,19,21,23-25,28H,6,8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01373
initial amount: NaN
is: CHEBI:27910
constant: false
is: SBO:0000247

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

metaM akg m
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:16810
is: HMDB00208
is: C00026
type: Species
name: 2-Oxoglutarate
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR GALt4
type: Reaction
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
product: MODEL1310110025#
fast: false
name: galactose transport via sodium symport
is described by: ECO:0000269
reactant: MODEL1310110025#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110025#_a74cd66f_4ab2_4201_8e5f_0bf54d65789e
is: SBO:0000252
type: Species
name: APRT
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:353
is: P07741
has only substance units: false
constant: false
boundary condition: true

metaM rib D e
type: Species
boundary condition: false
is: CHEBI:16988
constant: false
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
has only substance units: false
name: D-ribose
is: SBO:0000247
is: HMDB00283
initial concentration: 1.0
initial amount: NaN

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

metaR r2318
is described by: ECO:0000000
fast: false
reactant: MODEL1310110025#
product: MODEL1310110025#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
kinetic law: MODEL1310110025#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true

metaR XYLTt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES:NCD
name: Xylitol transport via passive diffusion
product: MODEL1310110025#
fast: false
kinetic law: MODEL1310110025#
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000185
reactant: MODEL1310110025#

metaM arachdcrn m
is: SBO:0000247
constant: false
name: C20:4 carnitine
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:57387
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
has only substance units: false
is: HMDB01322
initial amount: NaN

metaM mercplaccys c
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: 3-mercaptolactate-cysteine disulfide
constant: false
type: Species
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
is: HMDB06512
boundary condition: false
initial amount: NaN

metaR RDH2
name: retinol dehydrogenase (9-cis,NADH)
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368,PMID:9115228 NOTES:IT
fast: false
type: Reaction
modifier: MODEL1310110025#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.315
product: MODEL1310110025#
is: SBO:0000176
kinetic law: MODEL1310110025#
is described by: ECO:0000269
reactant: MODEL1310110025#

metaR PItn
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
is: SBO:0000185
type: Reaction
name: phosphate transport, nuclear
kinetic law: MODEL1310110025#
reversible: true
is described by: ECO:0000000
product: MODEL1310110025#

metaR r0502
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.7.1.113
fast: false
kinetic law: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
reactant: MODEL1310110025#
is: SBO:0000176
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
modifier: MODEL1310110025#
is described by: ECO:0000000
reversible: true

metaR r0716
is described by: ECO:0000000
reactant: MODEL1310110025#
product: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110025#
fast: false

metaR r1546
is: SBO:0000185
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaR r1659
fast: false
kinetic law: MODEL1310110025#
is described by: ECO:0000000
modifier: MODEL1310110025#
reactant: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110025#

metaM srtn c
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
is: SBO:0000247
is: HMDB00259
is: CHEBI:350546
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
type: Species
name: serotonin(1+)

metaM pmtcoa r
is: HMDB01338
is: CHEBI:3454
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
type: Species
has only substance units: false
is: C00154
name: Palmitoyl-CoA (n-C16:0CoA)
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaR EX mthgxl LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Methylglyoxal exchange
type: Reaction

metaM arg L e
is: HMDB00517
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
initial concentration: 1.0
is: CHEBI:32682
has only substance units: false
constant: false
initial amount: NaN
name: L-argininium(1+)
is: SBO:0000247
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_09b38081_5204_4e46_b02c_0a2bcd4bb806
type: Species
initial concentration: NaN
is: B4DK61
boundary condition: true
constant: false
is encoded by: hsa:51
name: ACOX1
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaM co2 r
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16526
name: CO2
constant: false
is: HMDB01967
has only substance units: false
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
type: Species
boundary condition: false
initial amount: NaN
is: C00011

metaM CE2435 m
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/5041
name: trans,cis-deca-2,4-dienoyl-CoA
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
type: Species
constant: false
is: C01936

metaR r0715
fast: false
is: SBO:0000176
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/6.3.2.5
notes: GENE_ASSOCIATION: (AI435857.1) or (79717.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reactant: MODEL1310110025#
reversible: false
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is described by: ECO:0000000
type: Reaction

metaR r1658
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110025#
is described by: ECO:0000000
modifier: MODEL1310110025#
is: SBO:0000185
type: Reaction
product: MODEL1310110025#
fast: false
kinetic law: MODEL1310110025#

metaR DURIPP
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
is version of: http://identifiers.org/ec-code/2.4.2.1
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.4.2.3
is: SBO:0000176
reversible: true
modifier: MODEL1310110025#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110025#
product: MODEL1310110025#
name: deoxyuridine phosphorylase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_e1fe705a_b096_42aa_bf68_59e3eaf4b3f0
boundary condition: true
constant: false
type: Species
initial amount: NaN
name: SLC25A15
is: Q9Y619
has only substance units: false
initial concentration: NaN
is encoded by: hsa:10166
is: SBO:0000252

metaR r1544
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110025#
product: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110025#_02b891a0_2baf_4e64_bc9c_bdb7bec3d189
name: EHHADH
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:1962
type: Species
is: Q9NY65

metaM sbt D e
name: D-glucitol
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
initial amount: NaN
is: HMDB00247

http://identifiers.org/biomodels.db/MODEL1310110025#_ccbce911_d686_47db_8515_5252cf57e9c3
name: GUK1
is encoded by: hsa:2987
type: Species
is: Q16774
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true

metaM h x
has only substance units: false
initial concentration: 1.0
is: CHEBI:24636
constant: false
initial amount: NaN
is: C00080
boundary condition: false
is: SBO:0000247
name: proton
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
type: Species
is: http://identifiers.org/pubchem.compound/3380

metaR CH25H
is version of: http://identifiers.org/ec-code/1.14.99.38
fast: false
modifier: MODEL1310110025#
is described by: ECO:0000269
product: MODEL1310110025#
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
is: SBO:0000176
name: cholesterol 25-hydroxylase
notes: GENE_ASSOCIATION: (9023.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
reversible: false

metaM HC02216 e
is: SBO:0000247
is: CHEBI:28922
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
name: prostaglandin-f2beta
constant: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
initial concentration: 1.0

metaR r2011
fast: false
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
product: MODEL1310110025#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
reversible: false

metaR ACONTm
product: MODEL1310110025#
modifier: MODEL1310110025#
reactant: MODEL1310110025#
reversible: true
kinetic law: MODEL1310110025#
name: Aconitate hydratase
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical
is described by: ECO:0000134
type: Reaction
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110025#_4cb5073d_f6fa_42e0_a28a_73e2c1d95187
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
is: P55084
type: Species
is encoded by: hsa:3032
name: HADHB

http://identifiers.org/biomodels.db/MODEL1310110025#_6e847b59_b8fd_4f59_b3ea_950f3dd4788f
has only substance units: false
constant: false
initial concentration: NaN
name: GLUL
is encoded by: hsa:2752
is: SBO:0000252
is: P15104
boundary condition: true
initial amount: NaN
type: Species

metaR ENO
modifier: MODEL1310110025#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (2023.1) or (2027.2) or (2027.1) or (2026.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.2.1.11 Confidence Level: 0 AUTHORS: PMID:5939,PMID:6626557 NOTES:SMP
name: enolase
kinetic law: MODEL1310110025#
type: Reaction
reactant: MODEL1310110025#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.11
is described by: ECO:0000134
product: MODEL1310110025#

metaM dhor S c
notes: FORMULA: C5H5N2O4 CHARGE: -1 INCHI: InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00285
name: (S)-dihydroorotate
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
is: HMDB03349
initial amount: NaN
is: CHEBI:30864
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_5f5ede3a_7e9c_44a5_9e11_fb42fbb9c331
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6553
initial concentration: NaN
type: Species
has only substance units: false
is: Q9NSW9
name: SLC9A5
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_07322c70_0148_493a_b4f1_378911fcb5db
is: P61457
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: PCBD1
constant: false
is encoded by: hsa:5092
type: Species
initial concentration: NaN
boundary condition: true

metaM rib D c
is: SBO:0000247
initial amount: NaN
is: HMDB00283
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
is: CHEBI:16988
name: D-ribose
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
constant: false

metaR EX gmp LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GMP exchange
type: Reaction

metaM nadph c
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: C00005
is: HMDB00221
boundary condition: false
constant: false
type: Species
is: CHEBI:57783
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
initial amount: NaN

metaR r1657
is: SBO:0000185
fast: false
modifier: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110025#
type: Reaction
reversible: true
product: MODEL1310110025#
kinetic law: MODEL1310110025#

metaR IPDDIx
type: Reaction
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.3.2
product: MODEL1310110025#
reactant: MODEL1310110025#
name: isopentenyl-diphosphate D-isomerase
notes: GENE_ASSOCIATION: (3422.1) or (91734.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ
fast: false
reversible: true
is described by: ECO:0000134

metaR r0714
product: MODEL1310110025#
is described by: ECO:0000000
reactant: MODEL1310110025#
type: Reaction
reversible: false
kinetic law: MODEL1310110025#
is: SBO:0000176
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
fast: false

metaM cyan c
has only substance units: false
initial amount: NaN
is: HMDB02084
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
constant: false
is: SBO:0000247
is: CHEBI:18407
name: hydrogen cyanide

metaR r2315
kinetic law: MODEL1310110025#
reversible: true
is: SBO:0000185
reactant: MODEL1310110025#
product: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR r0384
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
type: Reaction
product: MODEL1310110025#
reversible: false
reactant: MODEL1310110025#
is: SBO:0000176
kinetic law: MODEL1310110025#
name: 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110025#_1e4a7049_9258_4fe3_b27a_86ca38bc9814
is: SBO:0000252
initial concentration: NaN
is: P48067
constant: false
initial amount: NaN
is encoded by: hsa:6536
type: Species
name: SLC6A9
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110025#_ce943354_e9aa_48aa_8ed2_506d969cb251
type: Species
boundary condition: true
is encoded by: hsa:374291
name: NDUFS7
constant: false
is: SBO:0000252
is: O75251
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR CITt4 4
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110025#
product: MODEL1310110025#
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
is described by: ECO:0000006
fast: false
name: citrate transport via sodium symport
type: Reaction
reversible: true

metaR ACGALK
type: Reaction
reactant: MODEL1310110025#
is: SBO:0000176
name: N-acetylgalactosamine kinase
is described by: ECO:0000000
product: MODEL1310110025#
kinetic law: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: false

metaR r1298
name: Vesicular transport
reversible: false
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000000
type: Reaction

metaR r0652
modifier: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.2
is described by: ECO:0000000
kinetic law: MODEL1310110025#
reversible: true
type: Reaction
reactant: MODEL1310110025#
product: MODEL1310110025#
is: SBO:0000176
name: trans-Tetradec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38

metaM HC01115 c
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
is: CHEBI:29025
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
name: NeuNGc
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_da04ee4e_a2c6_45f2_967f_a7c77f236de8
is encoded by: hsa:1120
initial concentration: NaN
name: CHKB
is: Q9Y259
boundary condition: true
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
has only substance units: false

metaM retn e
constant: false
boundary condition: false
name: all-trans-retinoate
has only substance units: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
is: CHEBI:35291
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB01852
is: SBO:0000247

metaM cit e
is: HMDB00094
initial concentration: 1.0
has only substance units: false
name: citrate(3-)
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
boundary condition: false
is: CHEBI:16947
is: SBO:0000247

metaM pail4p hs n
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
boundary condition: false
constant: false
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
is: CHEBI:58178
has only substance units: false

metaM coa x
is: C00010
is: SBO:0000247
type: Species
initial amount: NaN
name: Coenzyme A
initial concentration: 1.0
is: HMDB01423
constant: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
boundary condition: false
has only substance units: false
is: CHEBI:57287

http://identifiers.org/biomodels.db/MODEL1310110025#_a6200ce1_8fec_48eb_9928_6a227be703e8
name: GAPDHS
is encoded by: hsa:26330
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
is: O14556
constant: false
initial amount: NaN

metaR EX udpgal LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP-D-galactose(2-) exchange
type: Reaction

metaM pan4p m
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:47942
name: pantetheine 4'-phosphate(2-)
is: HMDB01416
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110025#_ed4f8ca7_3bc2_4f53_87a3_bd08e9b045d8
initial concentration: NaN
constant: false
name: PIGP
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:51227
has only substance units: false

metaM ipdp c
boundary condition: false
is: C00129
name: Isopentenyl diphosphate
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01347
notes: FORMULA: C5H9O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
is: CHEBI:128769
has only substance units: false
type: Species

metaR r2314
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110025#

metaM HC02216 c
has only substance units: false
is: CHEBI:28922
name: prostaglandin-f2beta
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
constant: false
boundary condition: false
is: SBO:0000247

metaR BDHm
type: Reaction
product: MODEL1310110025#
is: SBO:0000176
is described by: ECO:0000269
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
fast: false
modifier: MODEL1310110025#
reversible: true
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.1.1.30

metaR r0385
product: MODEL1310110025#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
type: Reaction
name: 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
kinetic law: MODEL1310110025#
is: SBO:0000176
fast: false
reactant: MODEL1310110025#
is described by: ECO:0000000

metaR EX akg LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Oxoglutarate exchange
type: Reaction

metaR S4TASE2ly
name: N-acetylgalactosamine-4-sulfatase, lysosomal
type: Reaction
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/3.1.6.12
fast: false
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110025#

metaM glyc3p c
initial amount: NaN
is: HMDB00126
has only substance units: false
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
name: Glycerol 3-phosphate
is: CHEBI:57597
is: SBO:0000247
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: C00093

metaM sbt D c
initial amount: NaN
has only substance units: false
is: HMDB00247
name: D-glucitol
initial concentration: 1.0
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
boundary condition: false
is: SBO:0000247
constant: false
type: Species
is: CHEBI:17924

metaR ALAtN1
is described by: ECO:0000269
product: MODEL1310110025#
modifier: MODEL1310110025#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
name: Alanine transport (Na, H coupled)
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110025#_9fa7ae47_f5ba_4f4a_a1e0_417fdc38a05e
initial concentration: NaN
is encoded by: hsa:2746
constant: false
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
name: GLUD1
is: E9KL48
has only substance units: false

metaR r0651
kinetic law: MODEL1310110025#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
is: SBO:0000176
modifier: MODEL1310110025#
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.5.1.2
is described by: ECO:0000000
product: MODEL1310110025#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
type: Reaction

metaM glc D e
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB00122
name: D-glucose
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:4167
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040

metaR NADPtru
reactant: MODEL1310110025#
name: NADP transporter, endoplasmic reticulum
fast: false
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
type: Reaction
is: SBO:0000185
product: MODEL1310110025#
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110025#_298b1c6e_62f0_4001_a5a9_d64bd08a5224
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: SLC13A3
is: B4DIR8
initial concentration: NaN
is encoded by: hsa:64849
type: Species
has only substance units: false
constant: false

metaM cholcoaone x
is: HMDB06891
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C48H74N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-30,32-34,36,38-40,44,56,58-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/p-4/t24-,25?,26+,27-,28-,29+,30+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01473 EHMN_ABBREVIATION: C05467
has only substance units: false
is: CHEBI:58507
initial concentration: 1.0
name: 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA(4-)
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_d264b219_a1f5_4bd2_b833_e00c303fa179
initial amount: NaN
is encoded by: hsa:51227
type: Species
name: PIGP
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false

metaR THFtm
type: Reaction
product: MODEL1310110025#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
fast: false
is described by: ECO:0000000
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#

metaM cyan e
constant: false
is: SBO:0000247
is: HMDB02084
boundary condition: false
name: hydrogen cyanide
initial concentration: 1.0
type: Species
is: CHEBI:18407
has only substance units: false
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_66eb3308_c224_4bc1_9f82_b8495d1d02ac
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:5169
has only substance units: false
boundary condition: true
name: ENPP3
is: Q308M7

metaM ptth c
is: CHEBI:16753
type: Species
name: pantetheine
constant: false
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
initial amount: NaN
initial concentration: 1.0
is: HMDB03426
boundary condition: false
has only substance units: false
is: SBO:0000247

metaM 5aop m
initial concentration: 1.0
name: 5-Amino-4-oxopentanoate
boundary condition: false
is: SBO:0000247
is: CHEBI:17549
type: Species
initial amount: NaN
is: C00430
constant: false
is: HMDB01149
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_67e00a66_09e8_44d8_9120_abc37495a6bd
is: Q9Y2B2
boundary condition: true
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
name: PIGL
is: SBO:0000252
has only substance units: false
is encoded by: hsa:9487

http://identifiers.org/biomodels.db/MODEL1310110025#_ac54c358_70d6_4d51_91f0_1ae778ae6481
name: SLC6A3
type: Species
boundary condition: true
initial concentration: NaN
is: Q01959
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6531
constant: false
initial amount: NaN

metaR r0650
is: SBO:0000176
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
product: MODEL1310110025#
is described by: ECO:0000000
fast: false
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
is version of: http://identifiers.org/ec-code/4.1.1.36
reversible: true
type: Reaction
reactant: MODEL1310110025#

metaM retn c
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
name: all-trans-retinoate
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
initial concentration: 1.0
type: Species
is: CHEBI:35291
initial amount: NaN
is: HMDB01852

metaM cit c
initial concentration: 1.0
is: HMDB00094
name: Citrate
is: SBO:0000247
is: C00158
constant: false
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:16947
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_9bae63c8_7db2_4165_875d_9b3a927224e0
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
name: NME4
constant: false
is: O00746
is: SBO:0000252
is encoded by: hsa:4833
initial amount: NaN

metaR r2317
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110025#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110025#
type: Reaction
reactant: MODEL1310110025#
fast: false
reversible: true
is described by: ECO:0000000

metaM cmp n
is: HMDB00095
initial amount: NaN
is: CHEBI:60377
constant: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
type: Species
name: CMP(2-)
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaR H3MTer L
product: MODEL1310110025#
type: Reaction
is: SBO:0000176
name: H3 mannosyltransferase, endoplasmic reticulum
fast: false
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110025#
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (9488.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8861954 NOTES:NCD
kinetic law: MODEL1310110025#

metaR PCm
is described by: ECO:0000269
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (5091.1) or (5091.2) SUBSYSTEM: Pyruvate metabolism EC Number: 6.4.1.1 Confidence Level: 4 AUTHORS: PMID:6548474 NOTES:TV Metabolism at a glance
type: Reaction
fast: false
modifier: MODEL1310110025#
reactant: MODEL1310110025#
reversible: false
is: SBO:0000176
product: MODEL1310110025#
name: pyruvate carboxylase
is version of: http://identifiers.org/ec-code/6.4.1.1

metaR NRPPHRt4 2 r
type: Reaction
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
name: Norepinephrine reversible transport in via sodium symport (1:2)
product: MODEL1310110025#
fast: false
is: SBO:0000185
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB

metaM na1 r
is: HMDB00588
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
has only substance units: false
is: SBO:0000247
name: sodium(1+)
is: CHEBI:29101
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_9d1b3557_9578_49cf_88ca_7c9a924d6c76
has only substance units: false
initial concentration: NaN
boundary condition: true
name: AACS
initial amount: NaN
is: Q86V21
is encoded by: hsa:65985
type: Species
constant: false
is: SBO:0000252

metaR EX dcyt LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxycytidine
type: Reaction

metaM HC01162 c
has only substance units: false
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
is: SBO:0000247
boundary condition: false
constant: false
type: Species
is: CHEBI:58376
initial amount: NaN
initial concentration: 1.0
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate

metaR DGNSKm
name: deoxyguanosine kinase
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (1716.5) or (1716.1) or (1716.4) or (1716.2) or (1716.3) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 4 AUTHORS: PMID:12535661,PMID:8692979 NOTES:
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.113
is described by: ECO:0000269
product: MODEL1310110025#
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
modifier: MODEL1310110025#

metaM pmtcoa m
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
initial amount: NaN
name: Palmitoyl-CoA (n-C16:0CoA)
boundary condition: false
is: C00154
initial concentration: 1.0
is: HMDB01338
type: Species
has only substance units: false
is: CHEBI:57379
constant: false
is: SBO:0000247

metaR UMPK3n
fast: false
is: SBO:0000176
kinetic law: MODEL1310110025#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110025#
modifier: MODEL1310110025#
name: UMP kinase (UTP),nuclear
is described by: ECO:0000269
product: MODEL1310110025#

metaR TYRt
fast: false
kinetic law: MODEL1310110025#
reversible: true
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110025#
reactant: MODEL1310110025#
type: Reaction
name: L-tyrosine transport

metaM C02528 r
is: CHEBI:36234
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
name: chenodeoxycholate
constant: false
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
has only substance units: false
is: HMDB00518

metaR r1540
fast: false
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.17.4.1
type: Reaction
product: MODEL1310110025#
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
is: SBO:0000185
modifier: MODEL1310110025#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:

metaR r1299
name: Vesicular transport
is: SBO:0000185
reversible: false
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#

metaR RE1533M
modifier: MODEL1310110025#
product: MODEL1310110025#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
name: RE1533
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110025#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17

metaM arachcoa c
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
is: HMDB04258
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:15527
initial concentration: 1.0
name: arachidyl coenzyme A

metaM co2 m
type: Species
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: CO2
is: HMDB01967
constant: false
initial concentration: 1.0
is: C00011
is: CHEBI:16526
has only substance units: false

metaM cmp m
is: HMDB00095
type: Species
is: SBO:0000247
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
initial amount: NaN
name: CMP(2-)
boundary condition: false
constant: false
is: CHEBI:60377
initial concentration: 1.0
has only substance units: false

metaM mercplaccys e
boundary condition: false
constant: false
is: SBO:0000247
name: 3-mercaptolactate-cysteine disulfide
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB06512
initial amount: NaN
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110025#_a5d5b5a7_7b70_4bf3_a59a_1f82732f06ec
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: PRDX3
constant: false
initial amount: NaN
has only substance units: false
is: E9PH29
is encoded by: hsa:10935
type: Species

metaR HAtly
kinetic law: MODEL1310110025#
is: SBO:0000185
fast: false
type: Reaction
name: hyaluronan transport, extracellular to lysosome
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000000

metaR PSFLIPm
name: phosphatidylserine flippase
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ
modifier: MODEL1310110025#
product: MODEL1310110025#
reversible: false
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/3.6.3.1
fast: false
is: SBO:0000185

metaR URIt5le
is described by: ECO:0000134
name: uridine transport in via sodium symport (1:2)
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: false
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
product: MODEL1310110025#
is: SBO:0000185
modifier: MODEL1310110025#

metaM cdpdag hs m
constant: false
is: CHEBI:58332
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
is: SBO:0000247
name: CDP-diacylglycerol(2-)
type: Species

metaM occoa c
type: Species
has only substance units: false
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
initial amount: NaN
is: CHEBI:57386
boundary condition: false
is: SBO:0000247
name: Octanoyl-CoA (n-C8:0CoA)
constant: false
is: C01944
initial concentration: 1.0
is: HMDB01070

metaM dhdascb c
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
is: HMDB01264
type: Species
is: SBO:0000247
constant: false
name: dehydroascorbide(1-)
initial amount: NaN
is: CHEBI:58070

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_cd088895_8f9f_48ba_930a_fc8fb07c4efa
is: P21399
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: ACO1
type: Species
is encoded by: hsa:48
has only substance units: false
is: SBO:0000252
constant: false

metaR r1652
type: Reaction
reactant: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110025#
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110025#_dd89b375_1bcf_4a7d_bb34_b4caa730fb01
is encoded by: hsa:23428
initial concentration: NaN
boundary condition: true
type: Species
has part: Q86U05
has only substance units: false
is: SBO:0000297
constant: false
name: SLC7A8:SLC3A2
initial amount: NaN

metaR RE3218C
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.2
kinetic law: MODEL1310110025#
fast: false
name: RE3218
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
is: SBO:0000176
reactant: MODEL1310110025#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110025#

metaR TRPt
is: SBO:0000185
fast: false
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
name: L-tryptophan transport
is described by: ECO:0000269
type: Reaction
reversible: true

metaR GLUDxm
name: glutamate dehydrogenase (NAD) (mitochondrial)
reactant: MODEL1310110025#
is described by: ECO:0000269
modifier: MODEL1310110025#
reversible: true
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.4.1.3
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110025#
type: Reaction
fast: false

metaR ADSL1
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
modifier: MODEL1310110025#
reactant: MODEL1310110025#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110025#
fast: false
name: adenylosuccinate lyase
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/4.3.2.2

metaM leuktrD4 e
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
constant: false
is: SBO:0000247
is: HMDB03080
name: Leukotriene D4
has only substance units: false
initial concentration: 1.0
is: CHEBI:28666

metaM h n
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:24636
constant: false
initial amount: NaN
name: proton
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
has only substance units: false
type: Species
boundary condition: false

metaM ac m
type: Species
boundary condition: false
initial amount: NaN
name: acetate
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
constant: false
is: HMDB00042
is: CHEBI:30089
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaM nadph m
constant: false
type: Species
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: CHEBI:57783
name: Nicotinamide adenine dinucleotide phosphate - reduced
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: C00005
boundary condition: false
is: SBO:0000247
is: HMDB00221

metaR r0655
reversible: true
is: SBO:0000176
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.5.1.2
type: Reaction
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
product: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_827fa72a_7eaa_4732_b25c_2f6bcc1a147e
name: SLC17A2
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10246
initial amount: NaN
type: Species
constant: false
boundary condition: true
is: O00624
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_dc337581_ca9d_40eb_8a38_8ac3a58243d3
initial amount: NaN
is: P00558
is encoded by: hsa:5230
initial concentration: NaN
boundary condition: true
constant: false
name: PGK1
is: SBO:0000252
type: Species
has only substance units: false

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

metaM dopa c
initial concentration: 1.0
is: CHEBI:59905
constant: false
type: Species
name: dopaminium(1+)
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB00073
initial amount: NaN
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_1fbd9da1_c741_4ce4_9ce2_c8d10cb79221
initial amount: NaN
type: Species
is encoded by: hsa:AF116616
constant: false
initial concentration: NaN
boundary condition: true
name: _AF116616_1_m
has only substance units: false
is: SBO:0000252

metaR LINKDEG2ly
reactant: MODEL1310110025#
type: Reaction
name: degradation of proteoglycan linkage region, lysosomal
fast: false
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
product: MODEL1310110025#
reversible: false
is described by: ECO:0000000
is: SBO:0000176

metaM cmp g
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:60377
is: HMDB00095
name: CMP(2-)
has only substance units: false
boundary condition: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055

metaR r1651
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110025#
is described by: ECO:0000000
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

metaM 10fthf5glu e
is: HMDB00972
is: CHEBI:57454
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
name: 10-formyltetrahydrofolate-[Glu](5)
constant: false
notes: FORMULA: C40H45N11O19 CHARGE: -6
initial concentration: 1.0
initial amount: NaN

metaR r0381
is described by: ECO:0000000
reactant: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.8.1.3 Confidence Level: 0 AUTHORS: PMID:13979247,PMID:16680556,PMID:7295801 NOTES:
type: Reaction
reversible: true
name: hypotaurine:NAD+ oxidoreductase Taurine and hypotaurine metabolism EC:1.8.1.3
product: MODEL1310110025#
is: SBO:0000176
kinetic law: MODEL1310110025#

metaM akg e
is: CHEBI:16810
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB00208
name: 2-oxoglutarate(2-)
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_6ac4ad64_e4bb_4811_9fa2_dc85b315dbc3
is: Q02218
initial amount: NaN
name: OGDH
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:4967
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR L LACDcm
fast: false
modifier: MODEL1310110025#
name: L-Lactate dehydrogenase, cytosolic/mitochondrial
reversible: false
reactant: MODEL1310110025#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (124637.1) SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:18831974 NOTES:NCD/TDV. This reaction exists in yeast, but no evidence could be found this exists in humans. However, there may be intramitochondrial lactate dehydrogenase and lactate transport into mitochondria
product: MODEL1310110025#
is described by: ECO:0000000
kinetic law: MODEL1310110025#

metaM dem2emgacpail prot hs r
notes: FORMULA: C37H70N3O34P3FULLRCO2FULLR2CO2X CHARGE: 0
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: deacylated-(phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol
type: Species
constant: false
is: CHEBI:16004
initial concentration: 1.0
is: HMDB01311

metaR ICDHyrm
reactant: MODEL1310110025#
modifier: MODEL1310110025#
fast: false
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.42
is: SBO:0000176
type: Reaction
name: Isocitrate dehydrogenase (NADP+)
kinetic law: MODEL1310110025#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110025#_4f680f94_fe70_4487_b485_deb165a3d0a0
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: O75452
is: SBO:0000252
name: RDH16
boundary condition: true
is encoded by: hsa:8608
initial concentration: NaN

metaR DSREDUCr
reactant: MODEL1310110025#
modifier: MODEL1310110025#
reversible: false
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book.
is: SBO:0000176
name: Desmosterol reductase
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.72
is described by: ECO:0000134
kinetic law: MODEL1310110025#

metaR LPCOXp
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51268.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.3.7 Confidence Level: 4 AUTHORS: PMID:10772957 NOTES:
is version of: http://identifiers.org/ec-code/1.5.3.1
type: Reaction
modifier: MODEL1310110025#
is: SBO:0000176
fast: false
reversible: false
name: L-pipecolate oxidase, peroxisomal
product: MODEL1310110025#
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_d28b3ac3_9cb5_4042_8554_281639cc5cc6
is: Q16831
constant: false
name: UPP1
initial concentration: NaN
boundary condition: true
is encoded by: hsa:7378
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species

metaM dhdascb e
boundary condition: false
is: HMDB01264
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
initial amount: NaN
is: CHEBI:58070
name: dehydroascorbide(1-)

metaR RE2998M
name: RE2998
product: MODEL1310110025#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110025#
type: Reaction
reactant: MODEL1310110025#
modifier: MODEL1310110025#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.3.3.6

http://identifiers.org/biomodels.db/MODEL1310110025#_48b783eb_19e0_4936_a2d2_11db40d32467
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:26289
has only substance units: false
initial amount: NaN
type: Species
name: AK5
is: Q9Y6K8

http://identifiers.org/biomodels.db/MODEL1310110025#_5a7b7c63_9f82_4370_8243_1c32bf6dc1b6
type: Species
name: PCYT1A
initial concentration: NaN
is: P49585
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:5130
boundary condition: true

metaR DESAT22 2p
product: MODEL1310110025#
fast: false
reactant: MODEL1310110025#
is described by: ECO:0000000
type: Reaction
name: fatty acyl-CoA desaturase (n-C22:5CoA -> n-C22:6CoA)
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110025#

metaR r1650
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110025#
type: Reaction
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
product: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110025#_817e9c59_86c9_44c0_9c13_e1df68e6992a
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:AI440329
initial amount: NaN
name: _AI440329_1_r
type: Species

metaM 10fthf m
type: Species
initial concentration: 1.0
is: HMDB00972
name: 10-formyltetrahydrofolate(2-)
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:57454
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
has only substance units: false

metaR MTHFR3
is version of: http://identifiers.org/ec-code/1.5.1.20
product: MODEL1310110025#
name: 5,10-methylenetetrahydrofolatereductase (NADPH)
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (4524.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 2 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 350. NOTES:absorbed folate undergoes conversion to 5-methyl-THF within the enterocytes.
modifier: MODEL1310110025#
reversible: false
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110025#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110025#_724e254c_62c5_4010_9164_b70e19fa16d3
name: OXCT2
initial concentration: NaN
initial amount: NaN
is: Q9BYC2
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:64064

metaR GRTTx
is described by: ECO:0000134
kinetic law: MODEL1310110025#
product: MODEL1310110025#
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.5.1.1
reversible: false
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
reactant: MODEL1310110025#
type: Reaction
name: geranyltranstransferase

metaM leuktrD4 c
is: CHEBI:28666
type: Species
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
initial amount: NaN
has only substance units: false
name: Leukotriene D4
is: HMDB03080
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110025#_26a5867a_5e83_421f_91f0_67d1e0c33d55
initial concentration: NaN
is: Q9H0P0
constant: false
boundary condition: true
name: NT5C3
is encoded by: hsa:51251
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110025#_1b941feb_6af6_4054_9d9b_94e76b09342a
has only substance units: false
is: SBO:0000252
is encoded by: hsa:30
initial amount: NaN
initial concentration: NaN
type: Species
is: Q96CA6
constant: false
name: ACAA1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110025#_0a5ba4de_1ce6_4fd9_ba46_096cbe90a966
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:4967
name: OGDH
is: B4E3E9
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR EX tdchola LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: taurochenodeoxycholate exchange
type: Reaction

metaM 1p3h5c m
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
is: HMDB01369
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:6151
initial amount: NaN
constant: false

metaM xoltriol m
initial amount: NaN
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
is: SBO:0000247
is: CHEBI:16496
type: Species
has only substance units: false
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
constant: false
is: HMDB01457
boundary condition: false
initial concentration: 1.0

metaR r0653
type: Reaction
name: myristoyl-CoA:acetylCoA C-myristoyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is: SBO:0000176
product: MODEL1310110025#
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10706581,PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110025#_39c0bc65_3a49_4859_8496_d54beca04700
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
constant: false
name: _AA532636_1_m
is encoded by: hsa:AA532636

metaM glc D c
has only substance units: false
is: HMDB00122
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:4167
name: D-glucose
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
constant: false

metaM akg c
type: Species
is: CHEBI:16810
initial concentration: 1.0
is: C00026
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
initial amount: NaN
constant: false
name: 2-Oxoglutarate
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB00208

metaR GLUDym
reactant: MODEL1310110025#
type: Reaction
reversible: true
product: MODEL1310110025#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/1.4.1.3
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
name: glutamate dehydrogenase (NADP), mitochondrial
is: SBO:0000176

metaR r1656
reversible: true
reactant: MODEL1310110025#
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110025#
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110025#

metaM arachdcrn x
name: C20:4 carnitine
constant: false
is: http://identifiers.org/pubchem.compound/5462164
boundary condition: false
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB01064
initial concentration: 1.0

metaR EX imp LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_afa7b612_bd0e_4971_81b8_09f3b42cc850
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AU149534
type: Species
name: _AU149534_1_c
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false

metaR r2018
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
product: MODEL1310110025#
modifier: MODEL1310110025#
reversible: false
kinetic law: MODEL1310110025#
fast: false
reactant: MODEL1310110025#

metaM cmp c
is: CHEBI:60377
name: CMP
boundary condition: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
initial concentration: 1.0
is: HMDB00095
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
is: C00055
type: Species

metaM co2 c
notes: FORMULA: CO2 CHARGE: 0
boundary condition: false
is: CHEBI:3313
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: CO2
constant: false
is: C00011
is: HMDB01967
type: Species

metaR DM mem2emgacpail prot hs r
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM mem2emgacpail prot hs(r)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_f4ee9c9d_fac4_4c0d_8d50_eee82082ad53
has only substance units: false
is encoded by: hsa:159
type: Species
name: ADSS
initial concentration: NaN
boundary condition: true
is: P30520
constant: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110025#_e5a6ce3a_43fd_4d01_8f96_9d06bd0a914d
is: P15328
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:2348
name: FOLR1
type: Species
initial concentration: NaN

metaM HC01397 x
type: Species
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
boundary condition: false
has only substance units: false
is: SBO:0000247
name: (S)-3-Hydroxyhexadecanoyl-CoA
initial concentration: 1.0
is: CHEBI:27402
constant: false
initial amount: NaN

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_a4d2036c_db92_4035_9205_c784729c9680
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
name: SLC2A4
is: SBO:0000252
is: P14672
is encoded by: hsa:6517
constant: false

metaM dcyt n
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
type: Species
initial amount: NaN
constant: false
is: CHEBI:15698
is: HMDB00014
name: 2'-deoxycytidine
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110025#_90923dc0_9c5a_4d74_95fe_3c47a8152806
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1351
initial concentration: NaN
constant: false
is: Q53XN1
initial amount: NaN
type: Species
boundary condition: true
name: COX8A

metaM HC01104 e
initial concentration: 1.0
is: SBO:0000247
name: 4-nitrophenyl phosphate(2-)
constant: false
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
is: CHEBI:61146
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species

metaM o2 x
name: O2
has only substance units: false
is: C00007
type: Species
boundary condition: false
constant: false
is: HMDB01377
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: SBO:0000247
is: CHEBI:15379

metaM 10fthf e
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:57454
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: 10-formyltetrahydrofolate(2-)
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: HMDB00972
constant: false

metaR DNDPt35m
reversible: false
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110025#
kinetic law: MODEL1310110025#
type: Reaction
fast: false
is described by: ECO:0000269
reactant: MODEL1310110025#
is: SBO:0000185
name: dGDP transport via dADP antiport

metaM h r
initial amount: NaN
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
name: proton
is: CHEBI:24636
is: C00080
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3380
constant: false
has only substance units: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_a74e7df0_8a05_4d60_bcb0_4d37031b0181
initial concentration: NaN
is encoded by: hsa:22934
has only substance units: false
is: P49247
constant: false
initial amount: NaN
is: SBO:0000252
name: RPIA
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110025#_e6728729_f781_4ea8_9a10_e2edd5a54250
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: PANK2
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:80025
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_374ebb63_b327_4bff_ac9f_e03510ba31a4
name: AGPAT4
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:56895
is: Q9NRZ5
type: Species
is: SBO:0000252
initial amount: NaN

metaR EX thf LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5,6,7,8-Tetrahydrofolate exchange
type: Reaction

metaR RETI1
name: retinol isomerase (11-cis)
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110025#
fast: false
product: MODEL1310110025#
reversible: true
is: SBO:0000176
reactant: MODEL1310110025#

metaR 4HOXPACDOX NADP
modifier: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
name: 4-Hydroxyphenylacetaldehyde:NADP+ oxidoreductase
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
fast: false
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#

metaM pail45p hs n
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:28910
name: phosphatidylinositol 4,5-bisphosphate
boundary condition: false
type: Species

metaR r1655
modifier: MODEL1310110025#
is described by: ECO:0000000
reactant: MODEL1310110025#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110025#
kinetic law: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185

metaR r1088
is described by: ECO:0000000
name: Active transport
product: MODEL1310110025#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110025#
fast: false
reversible: true
kinetic law: MODEL1310110025#

metaM etha c
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
name: etha[c]
is: CHEBI:57603
has only substance units: false
notes: FORMULA: C2H8NO CHARGE: 1 INCHI: InChI=1S/C2H7NO/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00180 EHMN_ABBREVIATION: C00189
is: HMDB00149

http://identifiers.org/biomodels.db/MODEL1310110025#_06addc6d_be1f_4524_a383_2425c378a20b
initial concentration: NaN
has only substance units: false
is: Q5SYN6
name: SLC22A3
is encoded by: hsa:6581
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false

metaR PTPATe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
is described by: ECO:0000134
is: SBO:0000176
reactant: MODEL1310110025#
fast: false
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reversible: true
name: PTPATe

metaM em2emgacpail prot hs r
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:58121
initial amount: NaN
constant: false
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2X CHARGE: 0
type: Species
is: HMDB00618

metaR r1549
product: MODEL1310110025#
fast: false
kinetic law: MODEL1310110025#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110025#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true

metaM acgpail hs c
boundary condition: false
notes: FORMULA: C17H29NO14PFULLRCO2FULLR2CO2 CHARGE: -1 EHMN_ABBREVIATION: C01288
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:57265
name: 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(1-)
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_e51bd1c1_1a0d_4ef7_97c2_bfc94d39c6aa
is encoded by: hsa:56474
has only substance units: false
constant: false
type: Species
is: Q9NRF8
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: CTPS2
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_455818c1_6734_43ed_97b4_f2f5776cc7b1
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is: Q96CA6
is encoded by: hsa:30
is: SBO:0000252
name: ACAA1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_b781546d_01eb_4be9_94e4_accaca62746c
boundary condition: true
has only substance units: false
is: P50747
initial concentration: NaN
is encoded by: hsa:3141
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
name: HLCS

metaM 2maacoa m
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
is: SBO:0000247
type: Species
is: HMDB01157
boundary condition: false
constant: false
initial concentration: 1.0
name: 2-methylacetoacetyl-CoA(4-)
is: CHEBI:57335
initial amount: NaN
has only substance units: false

metaR RDH1
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110025#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.315
notes: GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES:IT
kinetic law: MODEL1310110025#
name: retinol dehydrogenase (all-trans)
fast: false
modifier: MODEL1310110025#
type: Reaction
product: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_eb76fdf8_3f0f_463c_a952_ab3aaf8801ec
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is: P47895
is encoded by: hsa:220
initial concentration: NaN
name: ALDH1A3

metaM cholcoar x
initial amount: NaN
boundary condition: false
type: Species
constant: false
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
is: CHEBI:58677
is: HMDB02178
has only substance units: false
is: SBO:0000247
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
initial concentration: 1.0

metaM dump c
initial amount: NaN
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
type: Species
constant: false
boundary condition: false
is: HMDB01409
is: CHEBI:246422
has only substance units: false
name: dUMP
is: SBO:0000247
is: C00365
initial concentration: 1.0

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

metaR H7MTer U
fast: false
modifier: MODEL1310110025#
reactant: MODEL1310110025#
name: H7 mannosyltransferase, endoplasmic reticulum
kinetic law: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (80235.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15208306 NOTES:NCD
is: SBO:0000176
reversible: false
type: Reaction

metaR O2t
is described by: ECO:0000000
reversible: true
product: MODEL1310110025#
is: SBO:0000185
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
kinetic law: MODEL1310110025#
type: Reaction
fast: false
name: o2 transport (diffusion)

metaR 5ADTSTSTERONESte
kinetic law: MODEL1310110025#
is described by: ECO:0000000
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
fast: false
is: SBO:0000185
reactant: MODEL1310110025#
name: sulfonated testosterone transport
type: Reaction
reversible: true

metaR RPE
type: Reaction
kinetic law: MODEL1310110025#
is described by: ECO:0000000
modifier: MODEL1310110025#
reactant: MODEL1310110025#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.1.3.1
reversible: true
name: ribulose 5-phosphate 3-epimerase
product: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP

metaR RBFK
reversible: false
name: riboflavin kinase
kinetic law: MODEL1310110025#
product: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
reactant: MODEL1310110025#
is: SBO:0000176
fast: false
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.7.1.26

metaR EX 2mcit LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Methylcitrate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_7da16c30_0a99_4176_8314_b46f4d69176f
constant: false
initial concentration: NaN
has only substance units: false
is: O00142
is: SBO:0000252
initial amount: NaN
type: Species
name: TK2
boundary condition: true
is encoded by: hsa:7084

http://identifiers.org/biomodels.db/MODEL1310110025#_f66080e4_3a6b_447e_84f6_592a7df62773
boundary condition: true
name: RDH12
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:145226
constant: false
has only substance units: false
initial concentration: NaN
is: Q96NR8

metaR r1654
reactant: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110025#
fast: false
kinetic law: MODEL1310110025#
product: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
reversible: true

metaR CBASPte
reversible: true
reactant: MODEL1310110025#
product: MODEL1310110025#
kinetic law: MODEL1310110025#
fast: false
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of N-carbamoyl-L-aspartate
is: SBO:0000185

metaM fum m
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
boundary condition: false
is: C00122
name: Fumarate
is: HMDB00134
initial concentration: 1.0
has only substance units: false
is: CHEBI:29806

metaR PItx
kinetic law: MODEL1310110025#
name: Phosphate transporter, peroxisome
fast: false
product: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reversible: true
type: Reaction
is described by: ECO:0000000
is: SBO:0000185

metaM cmp e
is: CHEBI:60377
name: CMP(2-)
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB00095
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
initial concentration: 1.0
constant: false
has only substance units: false
type: Species

metaM co2 e
is: CHEBI:16526
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
initial concentration: 1.0
constant: false
is: HMDB01967
has only substance units: false
is: C00011
type: Species
name: CO2

metaR FAOXC226
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
reversible: false
type: Reaction
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
kinetic law: MODEL1310110025#
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of long chain fatty acid
reactant: MODEL1310110025#
is described by: ECO:0000000
modifier: MODEL1310110025#

metaM CE2424 m
boundary condition: false
is: CHEBI:28387
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB11123
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA
constant: false
type: Species
has only substance units: false
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424

metaM aicar c
is: C04677
constant: false
type: Species
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
is: HMDB01517
is: CHEBI:58475
initial concentration: 1.0

metaM dopa e
is: CHEBI:59905
is: SBO:0000247
name: dopaminium(1+)
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
is: HMDB00073
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758

metaR r1548
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110025#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110025#
fast: false
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r0718
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
is described by: ECO:0000000
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
product: MODEL1310110025#
name: (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.181
is: SBO:0000176
modifier: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_75debac6_a854_4c8a_aa26_e416947af177
is encoded by: hsa:230
boundary condition: true
name: ALDOC
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: P09972

metaR r0443
product: MODEL1310110025#
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.42
reactant: MODEL1310110025#
is: SBO:0000176
reversible: false
modifier: MODEL1310110025#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110025#_767c5766_556c_4f1a_9a1b_b2ad83aa8e55
is: O75715
initial concentration: NaN
name: GPX5
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:2880

metaR r1653
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
product: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
modifier: MODEL1310110025#
type: Reaction

metaM dolichol U c
has only substance units: false
initial amount: NaN
constant: false
name: Dolichol, human uterine homolog
notes: FORMULA: C1025H1680O10 CHARGE: 0
boundary condition: false
is: SBO:0000247
is: CHEBI:16091
type: Species
initial concentration: 1.0

metaR LNLNCAt
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
reversible: true
product: MODEL1310110025#
is: SBO:0000185
is described by: ECO:0000000
fast: false
name: fatty acid transport via diffusion
reactant: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_fe7c3533_cb9c_40a0_97d7_3527f9cb6107
is: SBO:0000252
initial concentration: NaN
type: Species
is: O60503
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:115
name: ADCY9
has only substance units: false

metaM dhf c
initial amount: NaN
is: C00415
name: 7,8-Dihydrofolate
initial concentration: 1.0
is: CHEBI:57451
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB01056
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_e1a26b6b_32dc_4eed_9cb9_a3e29fdde79e
initial amount: NaN
is encoded by: hsa:728637
type: Species
constant: false
name: _728637_1_c
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR r0236
type: Reaction
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.6
is described by: ECO:0000000
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
product: MODEL1310110025#
reversible: true
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#

metaR CDIPTr
fast: false
kinetic law: MODEL1310110025#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.8.11
name: phosphatidylinositol synthase (Homo sapiens)
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD
reactant: MODEL1310110025#
type: Reaction
product: MODEL1310110025#
modifier: MODEL1310110025#

metaM acnamp c
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C11H17NO12P CHARGE: -3 INCHI: InChI=1S/C11H20NO12P/c1-4(13)12-7-5(14)2-11(19,10(17)18)24-9(7)8(16)6(15)3-23-25(20,21)22/h5-9,14-16,19H,2-3H2,1H3,(H,12,13)(H,17,18)(H2,20,21,22)/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01734 EHMN_ABBREVIATION: C06241
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
name: N-Acetylneuraminate 9-phosphate
is: CHEBI:27438
is: HMDB06268

metaR r1994
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110025#
fast: false
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#

metaR EX spmd LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of spermidine(3+)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_6999a6f3_a37a_4680_b73c_a0e4f643fada
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:155184
initial concentration: NaN
is: Q6PXP3
name: SLC2A7

metaM pmtcoa c
initial concentration: 1.0
is: SBO:0000247
is: HMDB01338
boundary condition: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
is: CHEBI:3454
type: Species
has only substance units: false
is: C00154
initial amount: NaN
constant: false
name: Palmitoyl-CoA (n-C16:0CoA)

metaM drib e
initial amount: NaN
is: CHEBI:28816
has only substance units: false
initial concentration: 1.0
constant: false
name: 2-deoxy-D-ribose
is: SBO:0000247
is: HMDB03224
type: Species
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
boundary condition: false

metaR r0962
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
is described by: ECO:0000000
product: MODEL1310110025#
reversible: false
type: Reaction
kinetic law: MODEL1310110025#
fast: false
reactant: MODEL1310110025#
name: Facilitated diffusion

metaM na1 c
has only substance units: false
is: C01330
notes: FORMULA: Na CHARGE: 1
name: Sodium
is: SBO:0000247
is: CHEBI:4541
constant: false
type: Species
initial amount: NaN
is: HMDB00588
boundary condition: false
initial concentration: 1.0

metaM aicar e
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
is: CHEBI:58475
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H13N4O8P CHARGE: -2
is: HMDB01517
boundary condition: false
initial amount: NaN
is: C04677

metaR r1429
kinetic law: MODEL1310110025#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
name: Free diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
reversible: true
reactant: MODEL1310110025#
product: MODEL1310110025#
fast: false

metaM ac e
has only substance units: false
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
type: Species
initial concentration: 1.0
is: CHEBI:30089
name: acetate
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB00042

metaR RBTt
product: MODEL1310110025#
name: ribitol transport via passive diffusion
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
kinetic law: MODEL1310110025#
fast: false
is: SBO:0000185
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110025#_7c6e3216_cd8b_4463_bc31_b28e682130c1
is: P11169
has only substance units: false
name: SLC2A3
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6515
constant: false
initial concentration: NaN
type: Species

metaM dcyt c
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
is: HMDB00014
has only substance units: false
is: C00881
type: Species
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
name: Deoxycytidine
is: CHEBI:15698
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110025#_e09190f0_a769_4a47_b30e_be849e800868
name: GPAA1
is: SBO:0000252
boundary condition: true
is encoded by: hsa:8733
is: O43292
initial concentration: NaN
type: Species
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_e372834f_9b96_4418_9920_c6f45bbf19f0
constant: false
has only substance units: false
is encoded by: hsa:51079
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
is: Q9P0J0
name: NDUFA13

http://identifiers.org/biomodels.db/MODEL1310110025#_c97a7d6d_5dda_4f35_bb4f_446ecadb5249
is: Q13907
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
name: IDI1
is: SBO:0000252
is encoded by: hsa:3422

metaM retn r
name: all-trans-retinoate
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:35291
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
initial amount: NaN
constant: false
is: HMDB01852
initial concentration: 1.0
boundary condition: false

metaR DNDPt18m
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
product: MODEL1310110025#
modifier: MODEL1310110025#
type: Reaction
reactant: MODEL1310110025#
reversible: false
kinetic law: MODEL1310110025#
fast: false
name: dUDP transport via ADP antiport

metaR 34DHOXPEGOX
product: MODEL1310110025#
reactant: MODEL1310110025#
name: 3,4-Dihydroxyphenylethyleneglycol:NAD+ oxidoreductase
is version of: http://identifiers.org/ec-code/1.1.1.1
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: (130.1) or (127.1) or (125.1 and 124.1) or (131.1) or (126.1 and 124.1) or (128.1) or (137872.1) or (125.1 and 126.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.1.1.1 Confidence Level: 4 AUTHORS: PMID:3466164 NOTES:SAB
modifier: MODEL1310110025#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.1.99.24

metaR r1995
fast: false
reactant: MODEL1310110025#
product: MODEL1310110025#
type: Reaction
modifier: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110025#
is described by: ECO:0000000

metaR r0224
modifier: MODEL1310110025#
fast: false
product: MODEL1310110025#
name: 5,6,7,8-Tetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate EC:1.5.1.3
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110025#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110025#_65ebcf07_f196_4955_868f_04c7ecaaa3a8
type: Species
boundary condition: true
is encoded by: hsa:F23536
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: _F23536_1_m
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_bfdb24d1_95c0_4260_9153_8673e061ab39
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AU149534
name: _AU149534_1_m

metaR CHOLt4
reversible: true
product: MODEL1310110025#
reactant: MODEL1310110025#
name: choline, sodium cotransport
is: SBO:0000185
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD
type: Reaction
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#

metaR ADNCYC
reversible: false
reactant: MODEL1310110025#
product: MODEL1310110025#
name: adenylate cyclase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.6.1.1
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
type: Reaction
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (112.1) or (55811.1) or (109.1) or (112.2) or (114.1) or (108.1) or (113.1) or (107.1) or (196883.1) or (115.1) or (111.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.1 Confidence Level: 4 AUTHORS: PMID:10481931,PMID:11299302,PMID:11423534,PMID:11840511,PMID:12503609,PMID:12609998,PMID:12623444,PMID:1427768,PMID:14996950,PMID:15547246,PMID:7860067,PMID:7959689,PMID:8076676 NOTES:JLR

metaR RTOTALt
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
name: RTOTAL transport
fast: false
reactant: MODEL1310110025#
reversible: true
type: Reaction
is: SBO:0000185
product: MODEL1310110025#
kinetic law: MODEL1310110025#

metaR EX aicar LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
type: Reaction

metaM h g
is: CHEBI:24636
name: proton
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080

metaR GGH 10FTHF6GLUe
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
fast: false
product: MODEL1310110025#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.19.9
kinetic law: MODEL1310110025#
name: Gamma-glutamyl hydrolase (10FTHF6GLU), extracellular
type: Reaction
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110025#
reactant: MODEL1310110025#

metaM dhf e
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
initial concentration: 1.0
is: CHEBI:57451
constant: false
is: SBO:0000247
name: dihydrofolate(2-)
is: HMDB01056
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false

metaM o2 m
is: C00007
initial amount: NaN
is: CHEBI:15379
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: SBO:0000247
type: Species
name: O2
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB01377
has only substance units: false

metaR FADH2tru
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
is described by: ECO:0000000
type: Reaction
fast: false
reversible: false
product: MODEL1310110025#
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
name: FADH2 transporter, endoplasmic reticulum

metaR 5MTHFt
fast: false
is: SBO:0000185
reversible: true
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
is described by: ECO:0000269
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
type: Reaction
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
product: MODEL1310110025#

metaR r1992
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
modifier: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
reactant: MODEL1310110025#
product: MODEL1310110025#
kinetic law: MODEL1310110025#
is described by: ECO:0000000
reversible: false

metaM HC01397 m
boundary condition: false
is: CHEBI:27402
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
has only substance units: false
name: (S)-3-Hydroxyhexadecanoyl-CoA
type: Species
initial concentration: 1.0

metaR r0960
reversible: true
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110025#
kinetic law: MODEL1310110025#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
type: Reaction
fast: false
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:

metaM bilirub e
is: CHEBI:57977
initial concentration: 1.0
is: HMDB00054
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
boundary condition: false
has only substance units: false
name: bilirubin(2-)
initial amount: NaN
is: SBO:0000247
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_6e996a82_66d2_4ff9_90fb_2b95194adf9b
initial amount: NaN
constant: false
type: Species
name: _AI480132_1_c
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AI480132
boundary condition: true

metaM pail4p hs c
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
initial concentration: 1.0
type: Species
is: CHEBI:58178
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaM 10fthf c
has only substance units: false
constant: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: CHEBI:57454
type: Species
is: C00234
initial concentration: 1.0
is: HMDB00972
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: 10-Formyltetrahydrofolate

http://identifiers.org/biomodels.db/MODEL1310110025#_23a21075_2e89_43a5_bdd2_ae39a14ba096
boundary condition: true
name: SDHD
is encoded by: hsa:6392
constant: false
is: O14521
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR IZPN
notes: GENE_ASSOCIATION: SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110025#
reversible: false
product: MODEL1310110025#
name: Imidazolonepropionase
fast: false
kinetic law: MODEL1310110025#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction

metaR BHBtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
reactant: MODEL1310110025#
fast: false
type: Reaction
kinetic law: MODEL1310110025#
is: SBO:0000185
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
is described by: ECO:0000000
product: MODEL1310110025#
reversible: true

metaR RE0453C
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
reversible: true
product: MODEL1310110025#
name: RE0453
is: SBO:0000176
type: Reaction
is described by: ECO:0000000

metaR RE1523M
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110025#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
name: RE1523
product: MODEL1310110025#
modifier: MODEL1310110025#
fast: false

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

metaR r1427
is: SBO:0000185
type: Reaction
product: MODEL1310110025#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#

metaM 4hoxpacd c
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB03767
initial amount: NaN
name: (4-hydroxyphenyl)acetaldehyde
notes: FORMULA: C8H8O2 CHARGE: 0 INCHI: InChI=1S/C8H8O2/c9-6-5-7-1-3-8(10)4-2-7/h1-4,6,10H,5H2 EHMN_ABBREVIATION: C03765
is: CHEBI:15621
type: Species
boundary condition: false
is: SBO:0000247

metaM ac c
is: HMDB00042
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
initial concentration: 1.0
type: Species
name: acetate
is: CHEBI:30089
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false

metaM na1 e
initial concentration: 1.0
is: C01330
has only substance units: false
is: SBO:0000247
notes: FORMULA: Na CHARGE: 1
name: Sodium
constant: false
is: CHEBI:4541
initial amount: NaN
type: Species
is: HMDB00588
boundary condition: false

metaM drib c
constant: false
name: 2-deoxy-D-ribose
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB03224
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
has only substance units: false
is: CHEBI:28816

metaR BILIRUBtr
product: MODEL1310110025#
kinetic law: MODEL1310110025#
type: Reaction
name: lipid, flip-flop intracellular transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110025#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110025#_1f43d551_5944_442f_a802_727b4056da07
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: TK2
type: Species
constant: false
is encoded by: hsa:7084
boundary condition: true
is: SBO:0000252
is: O00142

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_98b055c2_ca7c_4176_a5cf_36c519b15c90
initial amount: NaN
is: Q8IX04
has only substance units: false
name: UEVLD
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:55293

http://identifiers.org/biomodels.db/MODEL1310110025#_013c1596_1417_4cda_90dd_02f18b1b60cc
boundary condition: true
name: NDUFA3
is: O95167
type: Species
initial concentration: NaN
is encoded by: hsa:4696
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false

metaR C204CPT2
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110025#
reversible: false
kinetic law: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000000
is: SBO:0000176
fast: false
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TDV C20:4 transport
name: arachidonic acid transport into the mitochondria

metaR URATEt
is described by: ECO:0000000
reversible: false
type: Reaction
fast: false
kinetic law: MODEL1310110025#
name: urate export from cytosol
reactant: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110025#_ae45c770_f7e8_4af8_ae13_2adfaee48433
name: _NM_013421_1_m
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:NM 013421
constant: false
boundary condition: true

metaM nadph r
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: C00005
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:57783
constant: false
is: HMDB00221
is: SBO:0000247
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110025#_aa8ac5dd_f53d_4143_8bfe_de4f053143b4
initial amount: NaN
name: LDHAL6A
boundary condition: true
is: Q6ZMR3
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:160287
has only substance units: false

metaM retinal 11 cis c
type: Species
is: CHEBI:16066
has only substance units: false
name: 11-cis-retinal
constant: false
is: SBO:0000247
is: HMDB02152
initial amount: NaN
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
initial concentration: 1.0
boundary condition: false

metaM gacpail hs c
name: glucosaminyl-acylphosphatidylinositol
is: C00092
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:61548
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
is: HMDB01401
has only substance units: false
type: Species
boundary condition: false

metaR r1428
name: Free diffusion
is described by: ECO:0000000
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
product: MODEL1310110025#
reversible: true
fast: false
type: Reaction

metaR FAOXC18480m
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110025#
is described by: ECO:0000000
name: Beta oxidation of fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 4 degrees loss of saturation -> only 1 fad oxidized to fadh2 peroxisomal (very long chain FA) c18:4,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reversible: false
type: Reaction
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
product: MODEL1310110025#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110025#_ee2e8a92_4921_42f1_9a13_33390af1e9d4
has only substance units: false
type: Species
initial concentration: NaN
is: Q16881
name: TXNRD1
is encoded by: hsa:7296
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN

metaM 2aobut m
name: L-2-amino-3-oxobutanoic acid
type: Species
initial concentration: 1.0
is: CHEBI:40673
boundary condition: false
notes: FORMULA: C4H7NO3 CHARGE: 0 INCHI: InChI=1S/C4H7NO3/c1-2(6)3(5)4(7)8/h3H,5H2,1H3,(H,7,8)/t3-/m0/s1 EHMN_ABBREVIATION: C03508
initial amount: NaN
has only substance units: false
is: HMDB06454
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_1e82a0c7_4e70_48d4_b957_716c1c42f766
initial concentration: NaN
initial amount: NaN
name: HEPH
is encoded by: hsa:9843
constant: false
is: SBO:0000252
type: Species
boundary condition: true
is: E9PHN8
has only substance units: false

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

metaM focytC m
is: SBO:0000247
constant: false
boundary condition: false
name: Ferrocytochrome C
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
initial amount: NaN
has only substance units: false
is: CHEBI:16928
initial concentration: 1.0
type: Species

metaM succ m
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB00254
constant: false
name: Succinate
is: CHEBI:30031
boundary condition: false
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: C00042
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110025#_df510b9b_d67c_462c_8adb_1c6bdbb2f42a
has only substance units: false
constant: false
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:AA177072
is: SBO:0000252
name: _AA177072_1_c

http://identifiers.org/biomodels.db/MODEL1310110025#_d3bdcfec_756e_4bf4_95a1_1b3201fd2df3
initial amount: NaN
type: Species
is encoded by: hsa:220
is: P47895
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: ALDH1A3

metaR r1365
is: SBO:0000185
name: Vesicular transport
kinetic law: MODEL1310110025#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110025#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
reactant: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_37b42122_49e5_4f61_ae81_e396fe6f3935
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:51292
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
name: GMPR2

metaM 4izp c
boundary condition: false
is: SBO:0000247
name: 4-Imidazolone-5-propanoate
initial concentration: 1.0
has only substance units: false
is: CHEBI:57255
initial amount: NaN
is: HMDB01014
notes: FORMULA: C6H7N2O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01157 EHMN_ABBREVIATION: C03680
constant: false
type: Species

metaM bilirub c
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:57977
is: HMDB00054
type: Species
name: bilirubin(2-)
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110025#_aa600352_07df_4f07_a068_25bf5164ba03
is: P51178
type: Species
initial amount: NaN
is: SBO:0000252
name: PLCD1
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:5333
initial concentration: NaN

metaM gpail hs c
constant: false
type: Species
notes: FORMULA: C15H28NO13PFULLRCO2FULLR2CO2 CHARGE: 0 EHMN_ABBREVIATION: C04248
has only substance units: false
name: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
initial concentration: 1.0
boundary condition: false
is: CHEBI:17049
initial amount: NaN
is: SBO:0000247

metaM gal c
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:0
name: D-Galactose
is: C00124
initial concentration: 1.0
is: SBO:0000247
is: HMDB00143

http://identifiers.org/biomodels.db/MODEL1310110025#_3952bc31_0046_48c6_91c8_7d1b35a112b9
constant: false
name: HK1
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3098
is: P19367

metaR EX glyc LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycerol exchange
type: Reaction

metaR LDH L
reactant: MODEL1310110025#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.1.1.27
reversible: true
name: L-lactate dehydrogenase
fast: false
is described by: ECO:0000000
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D

metaM CE4790 m
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
is: CHEBI:12947
boundary condition: false
is: SBO:0000247
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
initial concentration: 1.0
type: Species

metaR METyLATthc
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Methionine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

metaR r1364
reversible: false
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110025#
is: SBO:0000185
name: Vesicular transport
kinetic law: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_90fe55a3_82ec_4a34_b42b_3f54b7ba9afc
is: SBO:0000252
initial amount: NaN
name: SLC27A1
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:376497
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_a6111dc0_af0a_411c_b23f_06f335fa8ca3
type: Species
initial amount: NaN
constant: false
name: VNN3
has only substance units: false
is encoded by: hsa:55350
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaM tchola c
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
boundary condition: false
name: taurocholic acid
is: SBO:0000247
has only substance units: false
is: CHEBI:36257
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00036
type: Species

metaM dump m
is: SBO:0000247
is: CHEBI:246422
type: Species
has only substance units: false
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
boundary condition: false
name: dUMP(2-)
constant: false
is: HMDB01409
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110025#_eeaf2702_5748_4208_99b5_92529366adc6
is: Q86YU0
is encoded by: hsa:766
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
has only substance units: false
initial amount: NaN
name: CA7
boundary condition: true

metaM C02528 e
initial amount: NaN
is: HMDB00518
boundary condition: false
name: chenodeoxycholate
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
has only substance units: false
is: SBO:0000247
is: CHEBI:36234
initial concentration: 1.0
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_aecdfb6b_917b_4d28_bb6f_764c21a0553b
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:4722
constant: false
is: O75489
name: NDUFS3
is: SBO:0000252
type: Species
boundary condition: true

metaR EICOSTETt
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110025#
type: Reaction
reversible: true
product: MODEL1310110025#
name: fatty acid transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110025#_94a67ba6_3e48_492b_b286_ee66177ce9f9
is encoded by: hsa:5277
is encoded by: hsa:8818
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
type: Species
is encoded by: hsa:5279
has part: B3KUV7
has part: Q92535
is encoded by: hsa:9091
has part: Q9BRB3
is encoded by: hsa:5283
has part: Q14442
constant: false
initial concentration: NaN
is: SBO:0000297
initial amount: NaN
boundary condition: true
is encoded by: hsa:51227
has only substance units: false
has part: O94777

metaR ORNt4m
fast: false
reversible: true
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
product: MODEL1310110025#
type: Reaction
reactant: MODEL1310110025#
name: ornithine mitochondrial transport exchange with citruline
is: SBO:0000185
kinetic law: MODEL1310110025#
is described by: ECO:0000269

metaR CHSTEROLt2
name: cholesterol intracellular transport
fast: false
is described by: ECO:0000000
product: MODEL1310110025#
type: Reaction
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

metaR NACHEX27ly
modifier: MODEL1310110025#
fast: false
kinetic law: MODEL1310110025#
type: Reaction
product: MODEL1310110025#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12562784 NOTES:NCD
is described by: ECO:0000269
reactant: MODEL1310110025#
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52

metaM 3hibutcoa m
has only substance units: false
initial amount: NaN
name: (S)-3-Hydroxyisobutyryl-CoA
is: CHEBI:28259
boundary condition: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
type: Species
is: HMDB01052
is: SBO:0000247
initial concentration: 1.0
constant: false

metaM fdp c
type: Species
is: SBO:0000247
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00300 EHMN_ABBREVIATION: C00354
is: http://identifiers.org/pubchem.compound/3647
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16905
is: C00354
name: D-Fructose 1,6-bisphosphate
is: HMDB01058
has only substance units: false

metaM arachdcrn c
initial concentration: 1.0
boundary condition: false
type: Species
name: C20:4 carnitine
has only substance units: false
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
constant: false
initial amount: NaN
is: HMDB01322
is: CHEBI:57387
is: SBO:0000247

metaM occoa m
type: Species
name: Octanoyl-CoA (n-C8:0CoA)
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB01070
is: C01944
constant: false
boundary condition: false
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: CHEBI:57386

metaM dd2coa m
name: trans-dodec-2-enoyl-CoA(4-)
is: SBO:0000247
is: HMDB03712
is: CHEBI:57330
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
type: Species

metaM 3mldz c
has only substance units: false
type: Species
constant: false
name: 1-methylimidazole-4-acetaldehyde
initial amount: NaN
is: CHEBI:28104
is: HMDB04181
notes: FORMULA: C6H8N2O CHARGE: 0 INCHI: InChI=1S/C6H8N2O/c1-8-4-6(2-3-9)7-5-8/h3-5H,2H2,1H3 EHMN_ABBREVIATION: C05827
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaM HC02206 e
name: prostaglandin C1(1-)
boundary condition: false
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57399

metaM hdd2coa x
name: (E)-hexadec-2-enoyl-CoA(4-)
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h16-17,24-26,30-32,36,47-48H,4-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b17-16+/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
is: HMDB03945
boundary condition: false
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:61526
initial amount: NaN

metaM o2 r
name: O2
initial concentration: 1.0
is: SBO:0000247
is: C00007
is: HMDB01377
initial amount: NaN
boundary condition: false
is: CHEBI:15379
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
has only substance units: false
constant: false
type: Species

metaR RE3005M
type: Reaction
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110025#
name: RE3005
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reactant: MODEL1310110025#
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
reversible: true

metaM trp L e
initial concentration: 1.0
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
boundary condition: false
is: CHEBI:16828
type: Species
initial amount: NaN
name: L-tryptophan
is: HMDB00929
is: SBO:0000247
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_9cea686e_df4c_4b3c_b5f4_5d4a82a5f598
is: Q96RV2
type: Species
initial concentration: NaN
boundary condition: true
name: HAS3
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:3038

metaR CHSTEROLt3
type: Reaction
name: cholesterol intracellular transport
product: MODEL1310110025#
fast: false
reversible: true
reactant: MODEL1310110025#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

metaM h l
initial concentration: 1.0
boundary condition: false
name: proton
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
is: C00080
notes: FORMULA: H CHARGE: 1 INCHI: "
is: CHEBI:24636
is: http://identifiers.org/pubchem.compound/3380

metaM pail45p hs c
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
name: phosphatidylinositol 4,5-bisphosphate
constant: false
is: CHEBI:28910
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaM akg x
boundary condition: false
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: CHEBI:16810
is: HMDB00208
type: Species
has only substance units: false
is: SBO:0000247
name: 2-oxoglutarate(2-)
initial concentration: 1.0
initial amount: NaN
constant: false

metaM gal e
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0
type: Species
is: C00124
is: CHEBI:0
has only substance units: false
is: SBO:0000247
name: D-Galactose
is: HMDB00143
initial concentration: 1.0

metaM dnad c
name: Deamino-NAD+
is: SBO:0000247
is: CHEBI:18304
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
is: HMDB01179
is: C00857
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_5eacbffa_78bc_4d27_8c61_a822b19976c7
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
name: _AI971036_1_c
is encoded by: hsa:AI971036
boundary condition: true
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_45f842b2_bc67_417e_bc6c_de259fc8e6a9
is encoded by: hsa:8776
has only substance units: false
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
name: MTMR1
is: Q13613
boundary condition: true

metaR GGH 5DHFe
is described by: ECO:0000000
product: MODEL1310110025#
type: Reaction
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
fast: false
is: SBO:0000176
reactant: MODEL1310110025#
name: Gamma-glutamyl hydrolase (5DHF), extracellular
is version of: http://identifiers.org/ec-code/3.4.19.9
reversible: false

metaR RNMK
is: SBO:0000176
kinetic law: MODEL1310110025#
reversible: false
is described by: ECO:0000269
fast: false
product: MODEL1310110025#
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (54981.1) SUBSYSTEM: NAD metabolism EC Number: 2.7.1.22 Confidence Level: 4 AUTHORS: PMID:15137942 NOTES:
name: ribosylnicotinamide kinase
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.7.1.22
type: Reaction

metaM stcoa m
has only substance units: false
boundary condition: false
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
initial concentration: 1.0
is: CHEBI:57394
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB01114
is: C00412
name: Stearoyl-CoA (n-C18:0CoA)

http://identifiers.org/biomodels.db/MODEL1310110025#_75139747_7e3f_49e5_87f2_262224f6cad5
name: _AI539321_1_c
is encoded by: hsa:AI539321
type: Species
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR r1872
type: Reaction
modifier: MODEL1310110025#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110025#
reversible: false
product: MODEL1310110025#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110025#

metaM dcyt e
type: Species
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
name: Deoxycytidine
is: HMDB00014
is: C00881
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:15698

metaM lanost r
is: CHEBI:16521
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00833 EHMN_ABBREVIATION: C01724
initial concentration: 1.0
constant: false
is: HMDB01251
has only substance units: false
type: Species
name: lanosterol

metaR DOPAt4 2 r
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reactant: MODEL1310110025#
is described by: ECO:0000269
reversible: true
type: Reaction
is: SBO:0000185
name: Dopamine reversible transport in via sodium symport (1:2)
kinetic law: MODEL1310110025#
product: MODEL1310110025#
fast: false

metaM tchola e
has only substance units: false
type: Species
notes: FORMULA: C26H45NO7S CHARGE: 0
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
name: taurocholic acid
is: HMDB00036

metaM h m
is: http://identifiers.org/pubchem.compound/3380
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:24636
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
name: proton
constant: false
is: C00080
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_48f91bb2_25d3_4ddd_9f53_343adc590189
constant: false
name: CHAT
is: SBO:0000252
is encoded by: hsa:1103
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: P28329

metaR DNDPt23m
type: Reaction
kinetic law: MODEL1310110025#
is: SBO:0000185
reversible: false
reactant: MODEL1310110025#
fast: false
product: MODEL1310110025#
is described by: ECO:0000269
modifier: MODEL1310110025#
name: dTDP transport via dGTP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110025#_25737cd3_3a0d_4538_8416_68f4cef85947
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
name: SLC26A6
is: Q9NQU1
initial concentration: NaN
boundary condition: true
is encoded by: hsa:65010
constant: false

metaM C02528 c
type: Species
constant: false
name: chenodeoxycholate
boundary condition: false
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
has only substance units: false
initial amount: NaN
is: HMDB00518
is: CHEBI:36234
is: SBO:0000247
initial concentration: 1.0

metaR ACACt2
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
name: acetoacetate transport via proton symport
fast: false
reversible: true
product: MODEL1310110025#
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
is described by: ECO:0000269
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110025#_3cfd8e0c_5882_4d1a_84df_8dab1e796077
is: SBO:0000252
is encoded by: hsa:8875
has only substance units: false
is: A8K7W0
type: Species
name: VNN2
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true

metaM trp L c
type: Species
is: CHEBI:16828
boundary condition: false
constant: false
initial concentration: 1.0
name: L-tryptophan
is: HMDB00929
has only substance units: false
initial amount: NaN
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
is: SBO:0000247

metaM HC02206 c
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:57399
initial concentration: 1.0
constant: false
name: prostaglandin C1(1-)
is: SBO:0000247

metaM dd2coa x
initial amount: NaN
is: CHEBI:57330
constant: false
boundary condition: false
type: Species
name: trans-Dodec-2-enoyl-CoA
is: HMDB03712
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaR DMATTx
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000134
modifier: MODEL1310110025#
reactant: MODEL1310110025#
name: dimethylallyltranstransferase
product: MODEL1310110025#
reversible: false
is version of: http://identifiers.org/ec-code/2.5.1.1
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ

metaR NTD2e
notes: GENE_ASSOCIATION: (4907.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:2840110 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
type: Reaction
is described by: ECO:0000134
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.5
reversible: false
reactant: MODEL1310110025#
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
product: MODEL1310110025#
name: 5'-nucleotidase (UMP), extracellular
is: SBO:0000176

metaR r1421
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110025#
type: Reaction
reversible: true
product: MODEL1310110025#
reactant: MODEL1310110025#
name: Free diffusion

metaM cs a l
initial concentration: 1.0
constant: false
is: HMDB06202
initial amount: NaN
type: Species
name: chondroitin sulfate A (GalNAc4S-GlcA), free chain
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
boundary condition: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_db986fa4_35b4_4b66_8a92_326afaa8ccb7
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
name: PCBD2
is encoded by: hsa:84105
has only substance units: false
is: SBO:0000252
is: Q9H0N5
type: Species

metaR r1148
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110025#
product: MODEL1310110025#
is: SBO:0000185
kinetic law: MODEL1310110025#
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
name: Active transport

metaM pyr m
is: HMDB00243
initial concentration: 1.0
boundary condition: false
is: CHEBI:15361
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/3324
type: Species
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
name: pyruvate
initial amount: NaN
is: C00022
constant: false

metaR r0720
fast: false
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000
is: SBO:0000176
name: (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
type: Reaction
reversible: false
kinetic law: MODEL1310110025#
product: MODEL1310110025#

metaR DHAAt1r
notes: GENE_ASSOCIATION: (6515.1) or (6513.1) or (6517.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:15705056,PMID:2656669,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
modifier: MODEL1310110025#
is described by: ECO:0000269
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
product: MODEL1310110025#
type: Reaction
is: SBO:0000185
fast: false
name: dehydroascorbate transport (uniport)
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110025#_25bbc70c_ac47_4356_808b_436dbe54d6dd
constant: false
is: SBO:0000252
initial amount: NaN
name: CA2
is encoded by: hsa:760
initial concentration: NaN
boundary condition: true
is: P00918
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_569549a3_1ba1_46e1_86bb_16814eda9011
is encoded by: hsa:2582
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
type: Species
is: Q38G75
initial concentration: NaN
name: GALE

metaR r2310
is: SBO:0000185
product: MODEL1310110025#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
is described by: ECO:0000000
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:

metaM o2 c
is: SBO:0000247
is: CHEBI:15379
initial concentration: 1.0
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
name: O2
is: HMDB01377
is: C00007
has only substance units: false
type: Species
constant: false
initial amount: NaN
boundary condition: false

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

metaM prpncoa m
initial concentration: 1.0
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
is: HMDB02307
name: acryloyl-CoA(4-)
is: CHEBI:57367
has only substance units: false
boundary condition: false

metaR ILETA
name: isoleucine transaminase
product: MODEL1310110025#
is described by: ECO:0000269
reactant: MODEL1310110025#
fast: false
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.6.1.42
kinetic law: MODEL1310110025#
reversible: true
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
is: SBO:0000176
type: Reaction

metaR r2526
type: Reaction
kinetic law: MODEL1310110025#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reactant: MODEL1310110025#
fast: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_c8fc6d93_93b9_41c2_803d_9d1bcfced923
is: Q9BY49
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:55825
is: SBO:0000252
name: PECR
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110025#_67fd1e0e_8d54_4581_9a1e_516a732c5bb4
initial amount: NaN
has only substance units: false
is: P45954
is encoded by: hsa:36
type: Species
boundary condition: true
initial concentration: NaN
name: ACADSB
is: SBO:0000252
constant: false

metaM triodthy e
initial concentration: 1.0
is: HMDB00265
is: CHEBI:18258
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
name: 3,3',5-triiodo-L-thyronine
type: Species
is: SBO:0000247

metaR DOLPMT3 Ler
is: SBO:0000176
type: Reaction
product: MODEL1310110025#
is described by: ECO:0000000
kinetic law: MODEL1310110025#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.4.1.260
reactant: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_a6f059d2_dba1_47e5_9eb2_5d21cfbfd99b
has only substance units: false
is encoded by: hsa:2645
name: GCK
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
type: Species

metaR r2311
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is: SBO:0000185
product: MODEL1310110025#
fast: false
reactant: MODEL1310110025#
reversible: true
kinetic law: MODEL1310110025#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000

metaM co2 x
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
is: HMDB01967
name: carbon dioxide
notes: FORMULA: CO2 CHARGE: 0 INCHI: InChI=1S/CO2/c2-1-3 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
has only substance units: false
constant: false
is: CHEBI:16526
is: SBO:0000247

metaM fum c
is: CHEBI:29806
initial amount: NaN
type: Species
boundary condition: false
is: HMDB00134
is: SBO:0000247
initial concentration: 1.0
name: Fumarate
is: C00122
constant: false
has only substance units: false
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122

metaM ru5p D c
name: D-ribulose 5-phosphate(2-)
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB00618
is: CHEBI:58121
initial concentration: 1.0

metaM maltpt e
initial amount: NaN
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5141
is: HMDB01296
has only substance units: false
type: Species
is: C02052
boundary condition: false
constant: false
name: maltopentaose

http://identifiers.org/biomodels.db/MODEL1310110025#_c63e12e3_ad6c_4f16_bad5_de57d85cc569
has only substance units: false
is encoded by: hsa:197257
type: Species
initial amount: NaN
boundary condition: true
constant: false
name: LDHD
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110025#_fc5d9285_3048_45e4_b26a_dce61ac98312
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:84720
name: PIGO
is: Q8TEQ8
type: Species
initial concentration: NaN
has only substance units: false

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_52234617_7cc7_416f_961a_e8a6eb3d44f8
has only substance units: false
name: NDUFS5
is: Q6IBA0
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:4725
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110025#_b1fe2731_eccf_4f36_b6ec_f5b5c6e783df
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
name: _R39999_1_c
constant: false
has only substance units: false
is encoded by: hsa:R39999
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_44b786c9_7216_4af0_aad0_22c9f01d0ece
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: Q8NEM3
is encoded by: hsa:9194
name: SLC16A7
is: SBO:0000252
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_072c4047_dcff_48ed_8163_fb1612aff261
constant: false
is: A8K3L7
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:10423
initial concentration: NaN
name: CDIPT
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110025#_fd2f5a5e_7bac_4552_86fb_1f7b4cca9f16
name: ALDH3B1
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:221
is: P43353
initial amount: NaN
has only substance units: false

metaR r2525
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
product: MODEL1310110025#
kinetic law: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_4b2b5f16_69e0_4210_a5bb_656189526e6b
name: PTS
is: Q03393
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
type: Species
is encoded by: hsa:5805
has only substance units: false

metaR r1762
is: SBO:0000185
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
reversible: false
type: Reaction
modifier: MODEL1310110025#
fast: false
reactant: MODEL1310110025#
product: MODEL1310110025#
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r2312
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
reversible: true
fast: false
product: MODEL1310110025#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction

metaR UAG4E
reversible: true
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/5.1.3.2
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES:NCD
name: UDP-N-acetylglucosamine 4-epimerase
is: SBO:0000176
fast: false
product: MODEL1310110025#
is described by: ECO:0000304
type: Reaction
reactant: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_6ca4911f_c97f_4917_8394_068d1b40ecca
is: P43353
boundary condition: true
name: ALDH3B1
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:221

metaM o2 e
initial concentration: 1.0
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: HMDB01377
has only substance units: false
is: SBO:0000247
is: CHEBI:15379
boundary condition: false
name: O2
initial amount: NaN
is: C00007
constant: false
type: Species

metaR r1090
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
fast: false
name: TCDB:2.A.47.1.9 TCDB:2.A.29.7.2
is described by: ECO:0000000
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110025#
type: Reaction

metaM xol7aone r
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
type: Species
constant: false
initial amount: NaN
is: HMDB01993
name: 7alpha-hydroxycholest-4-en-3-one
boundary condition: false
is: SBO:0000247
is: CHEBI:17899

metaR OROTGLUt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110025#
reversible: true
type: Reaction
name: OROTGLUt
is described by: ECO:0000134
is: SBO:0000185
reactant: MODEL1310110025#
product: MODEL1310110025#

metaM HC01603 c
constant: false
name: 10-Formyltetrahydrofolate
is: SBO:0000247
is: C00234
is: CHEBI:57454
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_45bbdcf6_3879_432d_b554_2748a9b1562f
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:2936
type: Species
boundary condition: true
constant: false
is: P00390
initial concentration: NaN
name: GSR

metaR DM dsT antigen g
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dsT antigen(g)
type: Reaction

metaM pan4p c
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
type: Species
is: HMDB01416
name: Pantetheine 4'-phosphate
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
is: C01134
is: CHEBI:47942

metaM triodthy c
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
is: HMDB00265
is: CHEBI:18258
has only substance units: false
boundary condition: false
name: 3,3',5-triiodo-L-thyronine
initial amount: NaN
constant: false
type: Species

metaR EX HC02207 LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-c2 exchange
type: Reaction

metaR TRIODTHYt2
product: MODEL1310110025#
name: T3 transport via facilitated diffusion
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
modifier: MODEL1310110025#
type: Reaction
fast: false
reactant: MODEL1310110025#
is: SBO:0000185
reversible: true
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110025#_8b7c43ac_4b5b_4aa3_9e78_f76d39f8d7e9
name: SLC29A2
is encoded by: hsa:3177
is: Q14542
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_c597c6c9_d72f_40bf_b8d5_1cee9474966c
boundary condition: true
is: Q9NY65
name: EHHADH
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:1962

metaR CMPSASn
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.43
product: MODEL1310110025#
is described by: ECO:0000304
reactant: MODEL1310110025#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
name: CMP sialic acid synthase, nuclear
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110025#_e1a0ccbe_a7db_476e_8290_7fe1080c7aa2
initial amount: NaN
is: Q13370
has only substance units: false
is: SBO:0000252
name: PDE3B
type: Species
is encoded by: hsa:5140
initial concentration: NaN
constant: false
boundary condition: true

metaM 1pipdn2c x
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
name: 1-piperideine-2-carboxylate
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092
initial amount: NaN
is: HMDB01084
type: Species
is: CHEBI:16187

metaR r2313
product: MODEL1310110025#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110025#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
kinetic law: MODEL1310110025#
is described by: ECO:0000000
fast: false

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

metaR EX HC02205 LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_a430da4b_08d6_4b8b_9cde_c187d03d3556
is encoded by: hsa:18
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: P80404
has only substance units: false
name: ABAT
constant: false
type: Species
initial amount: NaN

metaR C3STDH1r
is: SBO:0000176
reversible: false
type: Reaction
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.1.1.170
name: C-3 sterol dehydrogenase (4-methylzymosterol)
is described by: ECO:0000134
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER version NJ
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110025#_7c2b9286_8f78_4007_ba45_b3e71b35848a
name: SDHC
boundary condition: true
is encoded by: hsa:6391
is: Q99643
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false

metaR OCCOAtm
is described by: ECO:0000000
kinetic law: MODEL1310110025#
fast: false
name: Octanoyl-CoA transport, diffusion
reversible: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
reactant: MODEL1310110025#
product: MODEL1310110025#

metaR NAHCO3 HCLt
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
reactant: MODEL1310110025#
is described by: ECO:0000269
fast: false
is: SBO:0000185
product: MODEL1310110025#
kinetic law: MODEL1310110025#
name: bicarbonate transport (HCl/NaHCO3 exchange)
reversible: true
type: Reaction
modifier: MODEL1310110025#

metaR r1998
is: SBO:0000185
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000000
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaR VLCSp
fast: false
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: false
product: MODEL1310110025#
type: Reaction
is described by: ECO:0000269
name: Very-long-chain-fatty-acid-CoA ligase
modifier: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_8fd59003_0460_4ce7_90cf_cfb89ae6fcb6
constant: false
initial concentration: NaN
name: SLC6A9
is encoded by: hsa:6536
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
is: B7Z3W8
initial amount: NaN

metaR LNSTLSr
is described by: ECO:0000134
name: lanosterol synthase
notes: GENE_ASSOCIATION: (4047.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.4.99.7 Confidence Level: 2 AUTHORS: PMID:17925399,PMID:17925400,PMID:18830876,PMID:18830877 NOTES:NCD ER version - NJ
reversible: false
product: MODEL1310110025#
fast: false
reactant: MODEL1310110025#
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/5.4.99.7
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_98499887_fbe9_427e_b68b_eb4bf2ec619b
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: Q8N3E9
is encoded by: hsa:113026
type: Species
name: PLCD3
initial concentration: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_18136012_6b19_4924_ad65_12178a490cea
name: GMPPB
is encoded by: hsa:29925
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_986e03e4_a5fa_4217_9443_726567e1fe9d
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6566
name: SLC16A1
constant: false
initial amount: NaN
boundary condition: true
type: Species
is: B4DKS0

metaR DM ethamp r
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_4e8a4d36_b051_476e_9d8b_64c95e9bbc36
is encoded by: hsa:10965
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: ACOT2
is: P49753
has only substance units: false
initial amount: NaN
type: Species

metaR RE0453M
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
fast: false
modifier: MODEL1310110025#
type: Reaction
is: SBO:0000176
name: RE0453
is described by: ECO:0000000
kinetic law: MODEL1310110025#
reversible: true

metaM ptth m
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
is: CHEBI:16753
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
boundary condition: false
is: HMDB03426
initial concentration: 1.0
name: pantetheine

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

metaM pan4p e
notes: FORMULA: C11H21N2O7PS CHARGE: -2
boundary condition: false
constant: false
is: HMDB01416
initial amount: NaN
name: Pantetheine 4'-phosphate
initial concentration: 1.0
is: SBO:0000247
is: C01134
type: Species
has only substance units: false
is: CHEBI:47942

metaM glyc3p m
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
name: Glycerol 3-phosphate
is: SBO:0000247
is: CHEBI:57597
is: HMDB00126
constant: false
initial amount: NaN
is: C00093
type: Species

metaM pacald c
initial concentration: 1.0
is: CHEBI:16424
initial amount: NaN
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
constant: false
has only substance units: false
name: phenylacetaldehyde
is: SBO:0000247
type: Species
is: HMDB06236
boundary condition: false

metaR TYROXDAc
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.6 Confidence Level: 4 AUTHORS: PMID:11336106,PMID:14697899,PMID:8255365 NOTES:SAB also 1.4.3.4
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.4.3.4
type: Reaction
name: Tyramine:oxygen oxidoreductase(deaminating)(flavin-containing) (cytosol)
reactant: MODEL1310110025#
is described by: ECO:0000269
modifier: MODEL1310110025#
is: SBO:0000176
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110025#_7f3560c9_ebb2_4a79_812a_711ceb213099
is: Q13011
initial concentration: NaN
name: ECH1
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1891
constant: false
has only substance units: false
type: Species
boundary condition: true

metaM 4aphdob c
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
is: HMDB00978
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
is: CHEBI:58147
type: Species
is: SBO:0000247

metaM occoa x
boundary condition: false
is: HMDB01070
is: C01944
name: Octanoyl-CoA (n-C8:0CoA)
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
has only substance units: false
is: CHEBI:57386
type: Species

metaM gacpail hs r
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
is: C00092
initial amount: NaN
is: HMDB01401
has only substance units: false
initial concentration: 1.0
type: Species
name: glucosaminyl-acylphosphatidylinositol
is: CHEBI:61548

metaM nadph x
constant: false
type: Species
boundary condition: false
is: CHEBI:57783
is: C00005
initial amount: NaN
name: Nicotinamide adenine dinucleotide phosphate - reduced
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: HMDB00221
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaM thcholstoic m
type: Species
is: HMDB03873
boundary condition: false
initial concentration: 1.0
is: CHEBI:18402
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
constant: false
is: SBO:0000247
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_95c5b8c0_f2e4_4382_a896_dffd99b369b9
is: P07327
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:124
constant: false
boundary condition: true
name: ADH1A
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_2bf77bf8_4c7c_4246_b616_3876431dfc92
name: HSD17B10
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
is: Q99714
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3028
boundary condition: true

metaR r0870
is version of: http://identifiers.org/ec-code/3.6.4.13
is version of: http://identifiers.org/ec-code/3.1.3.4
reactant: MODEL1310110025#
modifier: MODEL1310110025#
reversible: true
is version of: http://identifiers.org/ec-code/3.6.1.1
is: SBO:0000185
is described by: ECO:0000000
name: Facilitated diffusion
type: Reaction
product: MODEL1310110025#
kinetic law: MODEL1310110025#
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.72
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:

metaM pa hs c
name: phosphatidate(2-)
is: SBO:0000247
is: CHEBI:57739
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species

metaR r0584
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
kinetic law: MODEL1310110025#
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000000
modifier: MODEL1310110025#
reactant: MODEL1310110025#
reversible: true
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9

http://identifiers.org/biomodels.db/MODEL1310110025#_ebb055f9_afa7_4068_bc60_dde2e586dd36
name: IDH2
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:3418
is: P48735
type: Species
is: SBO:0000252

metaR ARACHCRNt
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: transport into the mitochondria (carnitine)
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
product: MODEL1310110025#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110025#_579e0d2d_97b9_42a7_a351_57594fff3ceb
initial concentration: NaN
boundary condition: true
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:132789
is: SBO:0000252
has only substance units: false
is: Q8TDQ7
name: GNPDA2

http://identifiers.org/biomodels.db/MODEL1310110025#_41d23aaa_fe37_453b_87e3_8ff9760c0fd8
is: Q9NQ66
is encoded by: hsa:23236
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
name: PLCB1
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_9dfcedfb_1abc_4475_a121_fd6e42b04a36
initial amount: NaN
is encoded by: hsa:X63359
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
type: Species
name: _X63359_1_c
initial concentration: NaN

metaR SUCCTD
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_ff089ad7_9993_4336_9d05_e4a09252bdc5
has only substance units: false
name: AK5
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:26289

http://identifiers.org/biomodels.db/MODEL1310110025#_9bc8b541_9a66_42c6_af6f_55654be756cc
is: SBO:0000252
type: Species
boundary condition: true
name: _AI697028_1_e
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI697028

metaM C05957 r
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: Prostaglandin J2
has only substance units: false
is: HMDB02710
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
initial amount: NaN
constant: false
is: CHEBI:27485

metaM succ c
constant: false
is: CHEBI:30031
initial concentration: 1.0
is: SBO:0000247
name: Succinate
boundary condition: false
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
type: Species
is: HMDB00254
initial amount: NaN
has only substance units: false
is: C00042

http://identifiers.org/biomodels.db/MODEL1310110025#_bf941b7d_f8cf_4d43_8724_5435faa103f4
is encoded by: hsa:1716
is: SBO:0000252
has only substance units: false
is: E5KSL6
name: DGUOK
initial concentration: NaN
constant: false
boundary condition: true
type: Species
initial amount: NaN

metaR r0165
reversible: false
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
fast: false
reactant: MODEL1310110025#
type: Reaction
product: MODEL1310110025#
is described by: ECO:0000000
name: UTP:pyruvate O2-phosphotransferase EC:2.7.1.40
is: SBO:0000176
kinetic law: MODEL1310110025#

metaR HYXNt
fast: false
kinetic law: MODEL1310110025#
type: Reaction
is: SBO:0000185
product: MODEL1310110025#
modifier: MODEL1310110025#
reversible: true
is described by: ECO:0000269
name: Hypoxanthine transport
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
reactant: MODEL1310110025#

metaR r2521
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110025#
name: Utilized transport
type: Reaction
kinetic law: MODEL1310110025#
product: MODEL1310110025#

metaR r0587
reactant: MODEL1310110025#
is: SBO:0000176
kinetic law: MODEL1310110025#
type: Reaction
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110025#
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
modifier: MODEL1310110025#
reversible: true

metaR FMNAT
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.2
reversible: false
modifier: MODEL1310110025#
name: FMN adenylyltransferase
is described by: ECO:0000134
reactant: MODEL1310110025#
product: MODEL1310110025#
fast: false
type: Reaction
kinetic law: MODEL1310110025#

metaM h c
initial amount: NaN
is: SBO:0000247
constant: false
is: C00080
boundary condition: false
notes: FORMULA: H CHARGE: 1 INCHI: "
is: http://identifiers.org/pubchem.compound/3380
has only substance units: false
initial concentration: 1.0
name: proton
type: Species
is: CHEBI:24636

metaR r1423
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
name: Facilitated diffusion
kinetic law: MODEL1310110025#
is described by: ECO:0000000
reversible: false
type: Reaction
reactant: MODEL1310110025#
product: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_2b3111a9_48af_4e12_83c6_2f9a533407c2
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3074
constant: false
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
is: P07686
name: HEXB

metaM h e
constant: false
is: C00080
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: "
initial amount: NaN
is: CHEBI:24636
name: proton
initial concentration: 1.0
has only substance units: false
type: Species
is: http://identifiers.org/pubchem.compound/3380
boundary condition: false

metaM 13 cis retn r
is: HMDB06219
name: 13-cis-retinoate
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/7847414
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
is: D00348
initial concentration: 1.0

metaM gchola e
notes: FORMULA: C26H43NO6 CHARGE: 0
has only substance units: false
initial amount: NaN
is: HMDB00138
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
name: glycocholate
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110025#_b67dc043_d314_4c44_93a2_ed6197a59bdd
constant: false
has only substance units: false
name: ENO2
is encoded by: hsa:2026
is: SBO:0000252
initial amount: NaN
is: P09104
boundary condition: true
type: Species
initial concentration: NaN

metaR 2DR1PP
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.10 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
reversible: false
reactant: MODEL1310110025#
product: MODEL1310110025#
type: Reaction
name: 2-deoxy-D-ribose 1-phosphate phosphorylase
kinetic law: MODEL1310110025#

metaM r1p c
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442
is: CHEBI:57720
constant: false
name: alpha-D-Ribose 1-phosphate
is: C00442
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB01489

http://identifiers.org/biomodels.db/MODEL1310110025#_0e7a7111_e621_41f1_9e75_8cd862354fec
name: GCH1
initial amount: NaN
is: Q8IZH9
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2643
initial concentration: NaN
constant: false

metaM 4hpro LT m
has only substance units: false
name: trans-4-hydroxy-L-proline
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:18095
initial amount: NaN
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
boundary condition: false
is: HMDB00725

http://identifiers.org/biomodels.db/MODEL1310110025#_d1f5f1af_6774_44db_a542_c0db8d543c59
type: Species
has only substance units: false
is encoded by: hsa:10841
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
name: FTCD
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110025#_19becfd8_d55c_470e_b3a8_9ca1f0ec9de1
is encoded by: hsa:570
initial concentration: NaN
type: Species
is: Q14032
constant: false
boundary condition: true
name: BAAT
has only substance units: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_74784949_cc87_41ee_bc3c_580e97ede037
name: _2544_1_c
is encoded by: hsa:2544
has only substance units: false
initial concentration: NaN
type: Species
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR UMPK
is described by: ECO:0000269
reversible: true
name: UMP kinase
is: SBO:0000176
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110025#
product: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false

metaM cdpdag hs c
initial concentration: 1.0
has only substance units: false
name: CDP-diacylglycerol(2-)
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
type: Species
is: CHEBI:58332
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false

metaR r1147
product: MODEL1310110025#
reversible: true
type: Reaction
reactant: MODEL1310110025#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110025#
is: SBO:0000185
fast: false

metaM ser D c
initial amount: NaN
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
type: Species
is: CHEBI:16523
has only substance units: false
name: D-serine
boundary condition: false
is: HMDB03406
is: SBO:0000247
initial concentration: 1.0
constant: false

metaM rnam c
has only substance units: false
notes: FORMULA: C11H15N2O5 CHARGE: 1 INCHI: InChI=1S/C11H14N2O5/c12-10(17)6-2-1-3-13(4-6)11-9(16)8(15)7(5-14)18-11/h1-4,7-9,11,14-16H,5H2,(H-,12,17)/p+1/t7-,8-,9-,11-/m1/s1 EHMN_ABBREVIATION: C03150
boundary condition: false
type: Species
name: N-Ribosylnicotinamide
is: SBO:0000247
constant: false
is: HMDB00855
is: CHEBI:15927
initial amount: NaN
initial concentration: 1.0

metaR r2520
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.1
is described by: ECO:0000000
reversible: true
is: SBO:0000185
product: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418 NOTES:
reactant: MODEL1310110025#
fast: false
kinetic law: MODEL1310110025#

metaR r2386
fast: false
reactant: MODEL1310110025#
product: MODEL1310110025#
type: Reaction
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110025#
is described by: ECO:0000000
kinetic law: MODEL1310110025#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

http://identifiers.org/biomodels.db/MODEL1310110025#_31310cc7_5560_4627_ae33_9d003d86da09
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1962
is: Q9NY65
name: EHHADH
type: Species
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true

metaM HC02203 e
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
has only substance units: false
is: CHEBI:27820
is: SBO:0000247
constant: false
name: prostaglandin-a2
boundary condition: false

metaM pa hs m
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
constant: false
initial concentration: 1.0
name: phosphatidate(2-)
is: CHEBI:57739

metaM sphmyln hs c
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
boundary condition: false
name: sphingomyelin betaine
has only substance units: false
is: CHEBI:58216

http://identifiers.org/biomodels.db/MODEL1310110025#_c9e9b0d3_e011_46e1_a7a2_521499fc5442
initial amount: NaN
constant: false
name: _AI620219_1_e
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:AI620219
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110025#_6d2d6337_53d1_475a_99fa_74b8eecb6e9d
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5372
name: PMM1
boundary condition: true
constant: false
type: Species
is: A8K003
initial amount: NaN
is: SBO:0000252

metaM cdpchol c
initial amount: NaN
initial concentration: 1.0
name: CDPcholine
is: SBO:0000247
notes: FORMULA: C14H25N4O11P2 CHARGE: -1 INCHI: InChI=1S/C14H26N4O11P2/c1-18(2,3)6-7-26-30(22,23)29-31(24,25)27-8-9-11(19)12(20)13(28-9)17-5-4-10(15)16-14(17)21/h4-5,9,11-13,19-20H,6-8H2,1-3H3,(H3-,15,16,21,22,23,24,25)/t9-,11-,12-,13-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00263 EHMN_ABBREVIATION: C00307
has only substance units: false
constant: false
is: CHEBI:16436
is: HMDB01413
boundary condition: false
type: Species

metaR r0594
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: true
kinetic law: MODEL1310110025#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110025#
fast: false
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
product: MODEL1310110025#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110025#_1eccfc56_2e6c_44e2_9b85_859d31a0f7d2
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:8733
is encoded by: hsa:10026
has part: Q8NBL9
is encoded by: hsa:94005
type: Species
has part: Q92643
is encoded by: hsa:128869
boundary condition: true
initial concentration: NaN
has part: Q969N2
is: SBO:0000297
has part: Q9H490
has part: O43292
name: PIGK:PIGU:PIGT:GPAA1:PIGS
is encoded by: hsa:51604

http://identifiers.org/biomodels.db/MODEL1310110025#_7e175705_325a_4a7a_913d_b9252127e236
initial amount: NaN
is encoded by: hsa:AA664770
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
name: _AA664770_1_m
type: Species
boundary condition: true

metaR r1557
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110025#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110025#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110025#

metaM inost c
type: Species
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
is: SBO:0000247
name: myo-inositol
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00211
is: CHEBI:17268

metaR ADRNCOAtx
kinetic law: MODEL1310110025#
name: fatty acid intracellular transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is described by: ECO:0000000
reactant: MODEL1310110025#
product: MODEL1310110025#
reversible: true
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_d8b142e0_909b_4110_8188_6b20ca2d2a50
has only substance units: false
is: B7Z5T8
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:1375
boundary condition: true
name: CPT1B

http://identifiers.org/biomodels.db/MODEL1310110025#_5f48bfa0_576a_4719_9d3a_65cb083a351f
is: B3KXN9
boundary condition: true
is: SBO:0000252
constant: false
name: ADO
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:84890

metaR r2309
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reactant: MODEL1310110025#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is: SBO:0000185
fast: false

metaR CDPDAGtm
type: Reaction
kinetic law: MODEL1310110025#
is described by: ECO:0000000
reactant: MODEL1310110025#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
product: MODEL1310110025#
name: intracellular transport
fast: false

metaR r2387
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
fast: false
reactant: MODEL1310110025#
is: SBO:0000185
product: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_e3753a1b_4ad1_4460_afa0_95ce5d65eb44
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaR r0399
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
is version of: http://identifiers.org/ec-code/1.2.4.2
type: Reaction
kinetic law: MODEL1310110025#
reversible: true
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:
is: SBO:0000176
reactant: MODEL1310110025#
is described by: ECO:0000000
modifier: MODEL1310110025#
fast: false

metaM cholcoa x
is: HMDB01374
constant: false
name: choloyl-CoA(4-)
boundary condition: false
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:57373
is: SBO:0000247

metaR DPCOAK
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
modifier: MODEL1310110025#
name: dephospho-CoA kinase
reversible: false
is: SBO:0000176
product: MODEL1310110025#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.3
is described by: ECO:0000269

metaR G3PD1
type: Reaction
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.1.1.8
name: glycerol-3-phosphate dehydrogenase (NAD)
is: SBO:0000176
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
reversible: true
reactant: MODEL1310110025#
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#

metaR KYNAKGAT
is version of: http://identifiers.org/ec-code/2.6.1.7
is version of: http://identifiers.org/ec-code/2.6.1.64
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB
kinetic law: MODEL1310110025#
is: SBO:0000176
name: L-Kynurenine:2-oxoglutarate aminotransferase
type: Reaction
modifier: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000269
product: MODEL1310110025#
reversible: false
fast: false

metaR r1556
reactant: MODEL1310110025#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true
kinetic law: MODEL1310110025#
is described by: ECO:0000000

metaR SMS
product: MODEL1310110025#
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (259230.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14685263 NOTES:NJ
name: Sphingomyelin synthase (homo sapiens)
fast: false
reversible: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110025#
is described by: ECO:0000269
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.7.8.27

metaR BTND1
is version of: http://identifiers.org/ec-code/3.5.1.12
kinetic law: MODEL1310110025#
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110025#
reversible: false
fast: false
reactant: MODEL1310110025#
name: biotinidase (biotin)
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:IT
type: Reaction
product: MODEL1310110025#

metaR CYSTA
type: Reaction
reversible: true
is described by: ECO:0000304
reactant: MODEL1310110025#
is: SBO:0000176
product: MODEL1310110025#
fast: false
modifier: MODEL1310110025#
name: cysteine transaminase
is version of: http://identifiers.org/ec-code/2.6.1.1
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.3 Confidence Level: 2 AUTHORS: PMID:15189131,PMID:7113743 NOTES:MM
kinetic law: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_de58c51a_349a_4908_9376_5446eb75843d
is: Q92820
has only substance units: false
initial concentration: NaN
boundary condition: true
name: GGH
type: Species
initial amount: NaN
is encoded by: hsa:8836
constant: false
is: SBO:0000252

metaM dpcoa m
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
name: 3'-dephospho-CoA(2-)
constant: false
is: SBO:0000247
is: HMDB01373
boundary condition: false
initial amount: NaN
is: CHEBI:57328
has only substance units: false
type: Species
initial concentration: 1.0

metaM apoC c
constant: false
notes: FORMULA: XH CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB11111
type: Species
is: CHEBI:33190
has only substance units: false
name: Apocarboxlase (no lys residue)
initial amount: NaN

metaM pi x
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
name: hydrogenphosphate
is: HMDB00973
is: CHEBI:43474
type: Species
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaR r0512
type: Reaction
reactant: MODEL1310110025#
modifier: MODEL1310110025#
is: SBO:0000176
is described by: ECO:0000000
reversible: true
product: MODEL1310110025#
fast: false
is version of: http://identifiers.org/ec-code/1.17.4.1
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
kinetic law: MODEL1310110025#

metaM man6p c
boundary condition: false
initial amount: NaN
is: CHEBI:17369
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
is: HMDB01078
name: D-Mannose 6-phosphate
has only substance units: false
constant: false

metaR r0726
is described by: ECO:0000000
reactant: MODEL1310110025#
reversible: true
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
type: Reaction
kinetic law: MODEL1310110025#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.33
fast: false
modifier: MODEL1310110025#
product: MODEL1310110025#

metaR r1669
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110025#
fast: false
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110025#_0e6da186_3bcb_4ffd_92a1_9faa38361193
constant: false
name: GMPPA
is: SBO:0000252
is encoded by: hsa:29926
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN

metaR r2308
type: Reaction
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110025#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110025#
fast: false
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:

metaR EX dopa LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_33a0e44f_cb8c_4770_bcc9_d64bda81cd11
type: Species
is encoded by: hsa:158
constant: false
has only substance units: false
name: ADSL
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR GLNtN1
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is: SBO:0000185
name: Glutamine transport (Na, H coupled)
fast: false
modifier: MODEL1310110025#
reversible: true
type: Reaction
reactant: MODEL1310110025#
product: MODEL1310110025#
kinetic law: MODEL1310110025#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110025#_fff0c594_02af_4f93_838c_4b16eaf0caea
name: OGDH
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: Q02218
is: SBO:0000252
is encoded by: hsa:4967

http://identifiers.org/biomodels.db/MODEL1310110025#_3844a2a4_2ca2_4b76_8c42_c7b1a673ae4a
type: Species
initial amount: NaN
name: _BG035985_1_c
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:BG035985

metaR r2388
is: SBO:0000185
product: MODEL1310110025#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false
modifier: MODEL1310110025#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
fast: false
type: Reaction

metaR FOLR2
type: Reaction
name: folate reductase
is: SBO:0000176
fast: false
is described by: ECO:0000254
reversible: false
kinetic law: MODEL1310110025#
product: MODEL1310110025#
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.5.1.3
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_57f19009_d860_4992_b366_f0b6d4efde64
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: Q96E98
is encoded by: hsa:6005
type: Species
constant: false
boundary condition: true
name: RHAG
is: SBO:0000252

metaR r0660
fast: false
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reactant: MODEL1310110025#
reversible: true
type: Reaction
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
product: MODEL1310110025#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.2
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_ef5336f1_b7b2_4943_a5e0_2e1816cca1be
is: SBO:0000252
is encoded by: hsa:38
constant: false
type: Species
boundary condition: true
has only substance units: false
is: P24752
initial concentration: NaN
initial amount: NaN
name: ACAT1

metaR r1559
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110025#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110025#

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_6edaa015_d3f7_40cb_b059_3eadc854c780
constant: false
is encoded by: hsa:109
name: ADCY3
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: B3KT86
initial concentration: NaN
has only substance units: false

metaR AOBUTDsm
kinetic law: MODEL1310110025#
is: SBO:0000176
reversible: false
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12097150 NOTES:Spontaneous reaction
name: L-2-amino-3-oxobutanoate decarboxylation, mitochondrial (spontaneous)
reactant: MODEL1310110025#

metaM fe3 e
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
name: Fe3+
notes: FORMULA: Fe CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC01847
has only substance units: false
is: CHEBI:29034
is: HMDB12943

metaR DCTPtn
is described by: ECO:0000000
reactant: MODEL1310110025#
fast: false
name: dCTP diffusion in nucleus
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110025#
product: MODEL1310110025#

metaR ECOAH9m
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110025#
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
is: SBO:0000176
fast: false
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110025#_d338f11d_aed4_494d_8b66_265dc174e15b
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:3141
type: Species
name: HLCS
initial amount: NaN
is: SBO:0000252
is: P50747
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_045ec9e0_d320_42d3_96e3_de59f9882191
constant: false
is: SBO:0000252
type: Species
name: ST3GAL1
is encoded by: hsa:6482
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR r2389
fast: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110025#
reactant: MODEL1310110025#
product: MODEL1310110025#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110025#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110025#_426fe19a_dc03_4ad5_b7a1_d7fdda2cfa2c
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is: O00476
name: SLC17A3
is encoded by: hsa:10786
constant: false
type: Species

metaM cholate c
constant: false
initial amount: NaN
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
is: HMDB00619
is: SBO:0000247
is: CHEBI:29747
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: Cholate

metaR EX arach LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for arachidate
type: Reaction

metaM lnlncgcoa r
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: HMDB06368
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
name: gamma-linolenoyl-CoA(4-)
is: CHEBI:57363
type: Species

metaR r0728
reactant: MODEL1310110025#
type: Reaction
reversible: true
is: SBO:0000176
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110025#

metaM 2mp2coa m
type: Species
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
has only substance units: false
is: SBO:0000247
is: HMDB01011
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:27754
name: 2-Methylprop-2-enoyl-CoA

metaR r0514
kinetic law: MODEL1310110025#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:4396284,PMID:6882460,PMID:962851 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110025#
product: MODEL1310110025#
fast: false
type: Reaction
reactant: MODEL1310110025#
name: Dihydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110025#_fd5874fd_6643_4ec6_802f_d86c8978f34f
is: Q86VV3
constant: false
is encoded by: hsa:953
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
name: ENTPD1

metaM 4abut c
notes: FORMULA: C4H9NO2 CHARGE: 0
type: Species
initial amount: NaN
is: CHEBI:3628
is: HMDB00112
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
name: 4-Aminobutanoate
initial concentration: 1.0
is: C00334

metaR SERtN1
product: MODEL1310110025#
modifier: MODEL1310110025#
reversible: true
name: Serine transport (Na, H coupled)
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
kinetic law: MODEL1310110025#
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110025#

metaR r0437
modifier: MODEL1310110025#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
is version of: http://identifiers.org/ec-code/4.1.2.13
is: SBO:0000176
fast: false
reversible: true
product: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
kinetic law: MODEL1310110025#

metaM nad x
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3305
is: HMDB00902
name: Nicotinamide adenine dinucleotide
is: CHEBI:57540
initial concentration: 1.0
has only substance units: false
constant: false
is: C00003
boundary condition: false
is: SBO:0000247

metaR C226CPT2
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:TDV
reactant: MODEL1310110025#
is: SBO:0000176
kinetic law: MODEL1310110025#
type: Reaction
fast: false
product: MODEL1310110025#
reversible: false
name: C226 transport into the mitochondria
is described by: ECO:0000000

metaR r1553
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
reactant: MODEL1310110025#
is described by: ECO:0000000
product: MODEL1310110025#

metaR ALAt2r
reversible: true
name: L-alanine reversible transport via proton symport
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
fast: false
reactant: MODEL1310110025#
type: Reaction
product: MODEL1310110025#
is described by: ECO:0000304

metaM 3mob c
constant: false
is: SBO:0000247
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
is: CHEBI:11851
type: Species
has only substance units: false
initial amount: NaN
name: 3-methyl-2-oxobutanoate
boundary condition: false
initial concentration: 1.0
is: HMDB00019

http://identifiers.org/biomodels.db/MODEL1310110025#_695a5e8b_a72d_4ff1_847e_71f3f8ceac18
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:BF195998
type: Species
name: _BF195998_1_x
has only substance units: false
constant: false

metaR r2382
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
reactant: MODEL1310110025#
product: MODEL1310110025#
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: false
modifier: MODEL1310110025#

metaM bhb e
initial concentration: 1.0
is: CHEBI:10983
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
has only substance units: false
constant: false
is: SBO:0000247
name: (R)-3-hydroxybutyrate
is: HMDB00011
boundary condition: false
initial amount: NaN
type: Species

metaR r0590
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
product: MODEL1310110025#
modifier: MODEL1310110025#
reactant: MODEL1310110025#
reversible: false
fast: false
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
is: SBO:0000176
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110025#_0aab3f3f_c3d5_4454_b891_392811b6ff0e
has only substance units: false
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: HSD17B10
is: Q99714
is encoded by: hsa:3028

metaM HC01522 c
is: SBO:0000247
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585
name: Gentisate aldehyde
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:28508
has only substance units: false
boundary condition: false

metaM tmndnccoa m
constant: false
is: HMDB06514
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
name: timnodonyl coenzyme A
is: SBO:0000247

metaR r0394
kinetic law: MODEL1310110025#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
fast: false
product: MODEL1310110025#
reactant: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4

metaR 1PPDCRp
fast: false
is described by: ECO:0000000
reactant: MODEL1310110025#
name: delta1-piperideine-2-carboxylate reductase, perixosomal
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:MM
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110025#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110025#_803ac2a4_e2e7_4cb8_8df9_d48a4a8f4189
name: ACAA1
is encoded by: hsa:30
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: Q96CA6
has only substance units: false

metaR C226CPT1
product: MODEL1310110025#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
fast: false
modifier: MODEL1310110025#
reactant: MODEL1310110025#
reversible: false
kinetic law: MODEL1310110025#
name: carnitine C22:6 transferase
is described by: ECO:0000000
is: SBO:0000176

metaM C05280 m
is: CHEBI:28002
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280
has only substance units: false
name: cis,cis-3,6-Dodecadienoyl-CoA
is: HMDB03952
initial amount: NaN

metaM fe3 c
boundary condition: false
constant: false
notes: FORMULA: Fe CHARGE: 3
name: Fe3+
is: SBO:0000247
is: HMDB12943
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_23a96837_6d26_4d70_a192_05e2aebe37af
boundary condition: true
is encoded by: hsa:3295
type: Species
is: E9PB82
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
name: HSD17B4

metaR EX fol LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Folate
type: Reaction

metaM gly x
has only substance units: false
is: HMDB00123
constant: false
name: glycine
is: SBO:0000247
is: CHEBI:15428
notes: FORMULA: C2H5NO2 CHARGE: 0 INCHI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_9f6aecc4_3550_4e9f_8fa3_ed1c4a020e08
initial concentration: NaN
initial amount: NaN
name: BAAT
is encoded by: hsa:570
constant: false
is: Q14032
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR r1552
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
product: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
fast: false

metaR r1492
kinetic law: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reversible: false
name: Utilized transport
fast: false
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:

metaR r0591
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
product: MODEL1310110025#
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
is: SBO:0000176
reactant: MODEL1310110025#
type: Reaction
fast: false
kinetic law: MODEL1310110025#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
modifier: MODEL1310110025#

metaM dgtp n
is: C00286
is: HMDB01440
type: Species
name: dGTP
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:16497
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286

metaR DOLICHOL Uter
product: MODEL1310110025#
reversible: true
is described by: ECO:0000000
fast: false
name: dolichol diffusion, human (uterus)
type: Reaction
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000185

metaM em2emgacpail hs r
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol (H7)
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:16038
constant: false

metaR TALA
is: SBO:0000176
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
is version of: http://identifiers.org/ec-code/2.2.1.2
type: Reaction
reactant: MODEL1310110025#
fast: false
name: transaldolase
modifier: MODEL1310110025#
product: MODEL1310110025#

metaR r0722
product: MODEL1310110025#
modifier: MODEL1310110025#
is described by: ECO:0000000
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
type: Reaction
fast: false
reversible: true
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is version of: http://identifiers.org/ec-code/4.2.3.12
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110025#_8d9f83e2_ee16_4d5b_9e71_97cd53ef8cb8
boundary condition: true
type: Species
has only substance units: false
constant: false
is: Q14376
name: GALE
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2582

metaR ECOAH12m
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
is described by: ECO:0000304
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110025#
kinetic law: MODEL1310110025#
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
modifier: MODEL1310110025#
is: SBO:0000176
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
fast: false

metaR CSPG Atly
name: chondroitin sulfate A transport, extracellular to lysosome
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reactant: MODEL1310110025#

metaR r2384
type: Reaction
reactant: MODEL1310110025#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
product: MODEL1310110025#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110025#
reversible: false
modifier: MODEL1310110025#

metaR MAOX
is version of: http://identifiers.org/ec-code/1.4.3.21
type: Reaction
reversible: false
is described by: ECO:0000304
fast: false
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:11136547,PMID:14715500,PMID:9131641 NOTES:SAB
is: SBO:0000176
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.4.3.22
reactant: MODEL1310110025#
modifier: MODEL1310110025#
product: MODEL1310110025#
name: Methylamine oxidase

metaM 3mob e
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
is: CHEBI:11851
type: Species
initial amount: NaN
has only substance units: false
name: 3-methyl-2-oxobutanoate
is: HMDB00019
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247

metaR GPIDA2er
is: SBO:0000176
kinetic law: MODEL1310110025#
name: glycophosphatidylinositol (GPI) deacylase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (80055.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14734546 NOTES:NCD
modifier: MODEL1310110025#
reactant: MODEL1310110025#
type: Reaction
is described by: ECO:0000000
reversible: false
fast: false
product: MODEL1310110025#

metaR PNTEH
is: SBO:0000176
kinetic law: MODEL1310110025#
fast: false
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/3.5.1.92
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) SUBSYSTEM: CoA catabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10567687,PMID:11491533 NOTES:EC 3.5.1- KEGG RXN R02973 RM
is described by: ECO:0000269
type: Reaction
name: Hydrolase Class ( RXN R02973)
reversible: false
product: MODEL1310110025#
modifier: MODEL1310110025#

metaR r1493
reversible: false
reactant: MODEL1310110025#
fast: false
product: MODEL1310110025#
kinetic law: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:15845416 NOTES:
is: SBO:0000185
is described by: ECO:0000000
name: Utilized transport

metaR RE1807C
name: RE1807
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
product: MODEL1310110025#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110025#
reversible: true
fast: false

metaM dmnoncoa c
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
is: HMDB11604
is: SBO:0000247
has only substance units: false
name: 4,8 dimethylnonanoyl-CoA

metaR 41R1H2MAE12BOOX
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
name: 4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing)
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
is: SBO:0000176
fast: false
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.4.3.4
product: MODEL1310110025#
is described by: ECO:0000269
modifier: MODEL1310110025#

metaM tdcoa x
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: C02593
has only substance units: false
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
is: CHEBI:57385
is: SBO:0000247
constant: false
type: Species
name: Tetradecanoyl-CoA (n-C14:0CoA)
is: HMDB01521

metaM inost e
type: Species
name: myo-inositol
boundary condition: false
initial amount: NaN
is: HMDB00211
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
has only substance units: false
constant: false
is: CHEBI:17268
initial concentration: 1.0

metaR EX prostgf2 LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin F2alpha exchange
type: Reaction

metaR DM dem2emgacpail prot hs r
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dem2emgacpail prot hs(r)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_1e0841a6_f026_47e3_8b24_3cc35707f0ad
is: SBO:0000252
type: Species
constant: false
boundary condition: true
is encoded by: hsa:4907
has only substance units: false
name: NT5E
initial amount: NaN
is: P21589
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_46652512_1752_4125_8c54_76b861d955ad
initial amount: NaN
name: PDE10A
is: SBO:0000252
constant: false
is encoded by: hsa:10846
initial concentration: NaN
boundary condition: true
type: Species
is: Q9Y233
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_26bb91c5_d07c_43dd_b4c4_37e63eb9b0e5
is: Q96CA6
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:30
name: ACAA1

http://identifiers.org/biomodels.db/MODEL1310110025#_4606fc44_2918_41de_bd4f_2df532f69b5b
name: SLC4A1
constant: false
is: SBO:0000252
initial amount: NaN
is: P02730
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:6521

metaR r1554
reactant: MODEL1310110025#
product: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_0395f4c4_63ad_4763_93d7_c42c7368905c
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:AL038231
type: Species
initial concentration: NaN
name: _AL038231_1_c

http://identifiers.org/biomodels.db/MODEL1310110025#_c5daba16_c7fc_4a9a_912e_d63b87a45958
is: Q9Y2Q0
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: ATP8A1
initial concentration: NaN
is encoded by: hsa:10396
type: Species
constant: false
has only substance units: false

metaR r2385
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
product: MODEL1310110025#
modifier: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110025#_2281a426_16a5_405e_a8d5_7e90f75a0e4f
constant: false
type: Species
name: SLC20A1
is: Q8WUM9
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6574
has only substance units: false

metaM pe hs m
initial amount: NaN
boundary condition: false
name: phosphatidylethanolamine
constant: false
has only substance units: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
initial concentration: 1.0
is: CHEBI:16038
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110025#_1ca35e01_abbc_4bf3_8e89_bec6dc60706f
name: PANK2
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: Q6P1K9
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:80025

http://identifiers.org/biomodels.db/MODEL1310110025#_b67f301f_ae19_4402_b41b_f74f1c2bc038
initial concentration: NaN
is: P49448
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2747
initial amount: NaN
constant: false
type: Species
boundary condition: true
name: GLUD2

metaM ins c
is: HMDB00195
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: C00294
has only substance units: false
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
type: Species
is: CHEBI:17596
initial amount: NaN
name: Inosine

http://identifiers.org/biomodels.db/MODEL1310110025#_942c1177_5daf_40f1_a776_0f5c204a7140
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:5091
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
name: PC

http://identifiers.org/biomodels.db/MODEL1310110025#_c91b62c0_9273_4498_b922_32abfcd63a5d
initial concentration: NaN
is: SBO:0000252
is: Q15111
constant: false
type: Species
name: PLCL1
is encoded by: hsa:5334
initial amount: NaN
boundary condition: true
has only substance units: false

metaR HMGCOARc
type: Reaction
is described by: ECO:0000134
name: Hydroxymethylglutaryl CoA reductase (ir) in cytosol
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.34
product: MODEL1310110025#
kinetic law: MODEL1310110025#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). enzyme is located in E.R. but has catalytic site facing the cytosol (D.S. Sheriff (2004) Medical biochemistry, 1st edition Jaypee brothers Medical publishers pvt ltd page 502).
reversible: false
reactant: MODEL1310110025#
modifier: MODEL1310110025#

metaR r0724
is version of: http://identifiers.org/ec-code/2.7.1.33
is described by: ECO:0000000
product: MODEL1310110025#
reactant: MODEL1310110025#
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
type: Reaction
modifier: MODEL1310110025#
fast: false
kinetic law: MODEL1310110025#
is: SBO:0000176
reversible: true

metaR RE1534M
reactant: MODEL1310110025#
name: RE1534
kinetic law: MODEL1310110025#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110025#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110025#
reversible: true

metaM ala B m
boundary condition: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: beta-alanine
constant: false
is: CHEBI:16958
is: HMDB00056
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110025#_f7698db2_b40d_42f2_bac1_f4f7d7d77ef6
initial amount: NaN
is encoded by: hsa:130367
name: SGPP2
is: Q8IWX5
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_178a4283_35ce_4077_b048_0fd96a6101a2
is encoded by: hsa:151531
type: Species
name: UPP2
has only substance units: false
is: O95045
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_5f0dd23e_8cd6_4e81_87cb_c98e75a74818
is encoded by: hsa:240
name: ALOX5
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
is: P09917
constant: false

metaR GLCURtly
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD
product: MODEL1310110025#
modifier: MODEL1310110025#
is: SBO:0000185
kinetic law: MODEL1310110025#
name: glucuronate transport into lysososme
fast: false
is described by: ECO:0000269
reactant: MODEL1310110025#

metaR ACOAD1fm
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (80724.1) or (36.1) or (35.1) or (34.1) or (84129.1) or (27034.1) or (28976.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.3.99.2 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:Assume NAD/NADH as acceptors Lumped long-chain acyl-CoA dehydrogenase (EC 1.3.99.13) This reaction is therefore equilivalent to trans-2-enoyl-CoA reductase (NAD) (EC 1.3.1.44)
name: acyl-CoA dehydrogenase (butanoyl-CoA), mitochondrial
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
reactant: MODEL1310110025#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110025#
is: SBO:0000176
product: MODEL1310110025#

metaR RE1448N
is: SBO:0000176
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
type: Reaction
name: RE1448
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
reversible: true
product: MODEL1310110025#
is described by: ECO:0000000

metaM mmcoa S m
has only substance units: false
is: CHEBI:57327
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: (S)-methylmalonyl-CoA(5-)
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13+,16+,17+,18-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00495
constant: false
is: HMDB02310
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110025#_a4e0d913_087b_404c_be5e_a31967545a78
constant: false
is encoded by: hsa:8525
name: DGKZ
is: B7Z2M9
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR EX HC02202 LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin A1(1-) exchange
type: Reaction

metaR r0027
reversible: true
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.14.13.39
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
type: Reaction
is: SBO:0000176
product: MODEL1310110025#
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
modifier: MODEL1310110025#

metaR r0390
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
product: MODEL1310110025#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110025#
reversible: true
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
type: Reaction
fast: false
reactant: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_44f5d70f_67aa_49dd_89b2_1df9bb8eec4b
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:956
initial amount: NaN
name: ENTPD3
is: O75355
boundary condition: true
type: Species

metaR EX retinol cis 11 LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cis-11-retinol exchange
type: Reaction

metaM HC01403 m
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: (S)-Hydroxydecanoyl-CoA
constant: false
type: Species
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
is: CHEBI:28325
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110025#_5ef2be36_fbc5_4341_aee8_11a05f2f73fa
is: Q6FGA0
boundary condition: true
is: SBO:0000252
name: COX7A2L
is encoded by: hsa:9167
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
type: Species

metaR r1662
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
product: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: true

metaM duri e
initial amount: NaN
constant: false
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
initial concentration: 1.0
is: C00526
name: Deoxyuridine
is: SBO:0000247
is: CHEBI:16450
is: HMDB00012

metaM CE2434 m
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5041
initial concentration: 1.0
is: C01936
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
boundary condition: false
initial amount: NaN
constant: false
type: Species
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
has only substance units: false

metaM CE0849 m
initial concentration: 1.0
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849
has only substance units: false
initial amount: NaN
is: C01936
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/5041
name: cis,cis-palmito-7,10-dienoyl-CoA
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_ff07d1d8_7add_408a_9625_81c6faac0bbd
constant: false
is encoded by: hsa:3295
initial amount: NaN
has part: E9PB82
type: Species
is: SBO:0000297
has only substance units: false
initial concentration: NaN
name: ACAA1:HSD17B4:ACOX1
boundary condition: true

metaM nad r
has only substance units: false
name: NAD(1-)
is: CHEBI:57540
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB00902
initial concentration: 1.0

metaM pe hs c
is: CHEBI:16038
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
name: phosphatidylethanolamine
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_39d1aad7_663b_4311_891c_e18209eb8790
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is: O95822
is encoded by: hsa:23417
name: MLYCD

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

metaR H2O2t
kinetic law: MODEL1310110025#
fast: false
is: SBO:0000185
reactant: MODEL1310110025#
is described by: ECO:0000000
name: hydrogen peroxide transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF
reversible: true
type: Reaction
product: MODEL1310110025#

metaR CDS
type: Reaction
fast: false
reversible: false
kinetic law: MODEL1310110025#
product: MODEL1310110025#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.41
notes: GENE_ASSOCIATION: (1040.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:ER membrane - but on cytosolic surface NJ
reactant: MODEL1310110025#
is described by: ECO:0000000
name: phosphatidate cytidylyltransferase
modifier: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_58d1698f_15ec_43a8_aaa3_6ce87c621d7e
is encoded by: hsa:6390
has part: P31040
initial concentration: NaN
type: Species
has part: Q99643
has only substance units: false
has part: O14521
is encoded by: hsa:6392
boundary condition: true
is encoded by: hsa:6389
name: SDHA:SDHB:SDHC:SDHD
constant: false
has part: P21912
is: SBO:0000297
is encoded by: hsa:6391
initial amount: NaN

metaM m3gacpail hs r
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C49H88NO29PFULLRCO2FULLR2CO2 CHARGE: 0
name: trimannosyl-glucosaminyl-acylphosphatidylinositol (H4)
has only substance units: false
constant: false
type: Species
is: CHEBI:16038
boundary condition: false
initial concentration: 1.0

metaR r0968
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110025#
type: Reaction
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
fast: false
name: Postulated transport reaction
reactant: MODEL1310110025#
is: SBO:0000185

metaR HMGLm
modifier: MODEL1310110025#
type: Reaction
reactant: MODEL1310110025#
is described by: ECO:0000134
product: MODEL1310110025#
name: hydroxymethylglutaryl-CoA lyase
reversible: false
fast: false
kinetic law: MODEL1310110025#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.3.4
notes: GENE_ASSOCIATION: (3155.1) or (54511.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11129331 NOTES:TV

metaM dpcoa e
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: C00882
constant: false
is: HMDB01373
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
initial amount: NaN
name: Dephospho-CoA
is: CHEBI:57328
has only substance units: false

metaR r0391
is: SBO:0000176
is described by: ECO:0000000
fast: false
reactant: MODEL1310110025#
reversible: true
product: MODEL1310110025#
type: Reaction
kinetic law: MODEL1310110025#
name: Nicotinate D-ribonucleotide:pyrophosphate phosphoribosyltransferase Nicotinate and nicotinamide metabolism EC:2.4.2.11
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 2.4.2.11 Confidence Level: 0 AUTHORS: PMID:17604275 NOTES:

metaR HMGCOASim
reversible: false
reactant: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
is: SBO:0000176
name: Hydroxymethylglutaryl CoA synthase (ir)
fast: false
modifier: MODEL1310110025#
is described by: ECO:0000269
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.3.3.10
type: Reaction

metaR r1661
kinetic law: MODEL1310110025#
product: MODEL1310110025#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
fast: false
is: SBO:0000185
modifier: MODEL1310110025#
is described by: ECO:0000000
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR ATP2ter
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false
name: AMP/ATP transporter, endoplasmic reticulum
kinetic law: MODEL1310110025#
is: SBO:0000185
reactant: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_cd42bb0e_7be6_4937_b049_4c6eb255f578
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is: P32019
is: SBO:0000252
boundary condition: true
name: INPP5B
type: Species
is encoded by: hsa:3633

metaM aacoa m
constant: false
initial concentration: 1.0
type: Species
is: HMDB01484
initial amount: NaN
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
has only substance units: false
boundary condition: false
is: CHEBI:57286
name: acetoacetyl-CoA(4-)
is: SBO:0000247

metaR r0668
reactant: MODEL1310110025#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110025#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.2.19
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
modifier: MODEL1310110025#
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
fast: false
type: Reaction

metaM dhf m
initial concentration: 1.0
is: CHEBI:57451
boundary condition: false
has only substance units: false
is: SBO:0000247
name: dihydrofolate(2-)
constant: false
is: HMDB01056
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
type: Species
initial amount: NaN

metaM 7dhchsterol c
initial amount: NaN
is: HMDB00032
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
is: CHEBI:17759
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: cholesta-5,7-dien-3beta-ol
type: Species

metaR r1008
product: MODEL1310110025#
name: Facilitated diffusion
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
fast: false
reactant: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_75e93ebd_39a5_45cd_a2fa_0706fdb88e82
type: Species
is encoded by: hsa:8871
is: O15056
boundary condition: true
is: SBO:0000252
has only substance units: false
name: SYNJ2
initial amount: NaN
constant: false
initial concentration: NaN

metaM coa c
notes: FORMULA: C21H32N7O16P3S CHARGE: -4
type: Species
has only substance units: false
name: Coenzyme A
is: C00010
is: CHEBI:3312
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB01423

metaR EX galside hs LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-galactosyl-N-acylsphingosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_19e16a34_2dc3_4b90_82c4_0a92a0a63a36
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:3417
is: O75874
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
name: IDH1

http://identifiers.org/biomodels.db/MODEL1310110025#_d86285cb_37cb_4c30_8375_90f145b90071
name: CYP27A1
is: SBO:0000252
is: Q02318
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:1593
boundary condition: true
constant: false
initial concentration: NaN

metaR MALtm
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
reactant: MODEL1310110025#
product: MODEL1310110025#
is: SBO:0000185
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:IF
fast: false
name: malate transport, mitochondrial
reversible: true
is described by: ECO:0000269
type: Reaction

metaM man1p c
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: D-Mannose 1-phosphate
constant: false
is: CHEBI:35374
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
initial concentration: 1.0
type: Species
is: HMDB06330

metaR PROSTGI2t
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
fast: false
name: Prostaglandin I2 transport
is described by: ECO:0000269
product: MODEL1310110025#
reversible: true
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#

metaM ha l
initial amount: NaN
constant: false
name: hyaluronan
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
is: SBO:0000247
is: CHEBI:16336

metaR CEPTC
is described by: ECO:0000269
kinetic law: MODEL1310110025#
fast: false
is version of: http://identifiers.org/ec-code/2.7.8.2
is: SBO:0000176
product: MODEL1310110025#
reversible: false
name: choline phosphotransferase
type: Reaction
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (10390.1) or (56994.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110025#

metaM bhb c
is: CHEBI:10983
type: Species
name: (R)-3-hydroxybutyrate
boundary condition: false
is: HMDB00011
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
initial concentration: 1.0

metaM dhcrm hs c
type: Species
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:31488
boundary condition: false
name: dihydroceramide

metaM rbt c
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
name: D-ribitol
is: SBO:0000247
is: HMDB00508
constant: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
is: CHEBI:15963

metaR r1664
product: MODEL1310110025#
type: Reaction
modifier: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
reversible: true
kinetic law: MODEL1310110025#
is: SBO:0000185
reactant: MODEL1310110025#

metaR r0392
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
is described by: ECO:0000000
product: MODEL1310110025#
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
reversible: true
kinetic law: MODEL1310110025#
type: Reaction
reactant: MODEL1310110025#
fast: false

metaM peamn c
is: SBO:0000247
notes: FORMULA: C8H12N CHARGE: 1 INCHI: InChI=1S/C8H11N/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7,9H2/p+1 EHMN_ABBREVIATION: C05332
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
is: HMDB12275
is: CHEBI:225237
name: 2-phenylethanaminium
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_a7876208_3f5d_4c5f_9395_d372520e2e7a
has only substance units: false
is: Q9NP59
type: Species
is encoded by: hsa:30061
initial concentration: NaN
name: SLC40A1
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false

metaR O2tm
type: Reaction
reversible: true
reactant: MODEL1310110025#
name: O2 transport (diffusion)
is: SBO:0000185
product: MODEL1310110025#
is described by: ECO:0000000
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
fast: false

metaR FAOXC160
name: Beta oxidation of long chain fatty acid
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
kinetic law: MODEL1310110025#
is: SBO:0000176
product: MODEL1310110025#
modifier: MODEL1310110025#
reversible: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_2535848f_0664_4ef6_804d_bf9ce5da05d0
constant: false
name: CCBL1
is: Q16773
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:883
initial concentration: NaN
type: Species
is: SBO:0000252

metaR SAMHISTA
is: SBO:0000176
fast: false
name: S-Adenosyl-L-methionine:histamine N-tele-methyltransferase
notes: GENE_ASSOCIATION: (3176.1) SUBSYSTEM: Histidine metabolism EC Number: 2.1.1.8 Confidence Level: 4 AUTHORS: PMID:7943261 NOTES:SAB R02155
is described by: ECO:0000269
type: Reaction
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.1.1.8
reversible: false
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
reactant: MODEL1310110025#

metaM duri c
is: C00526
initial amount: NaN
name: Deoxyuridine
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB00012
constant: false
type: Species
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: CHEBI:16450

metaR H6ET3er
product: MODEL1310110025#
reactant: MODEL1310110025#
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (84720.2) and (5281.1) or (84720.1) and (5281.2) or (5281.1) and (84720.1) or (84720.2) and (5281.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10781593,PMID:8463218 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110025#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.8.1
reversible: false
fast: false
type: Reaction
name: H6 phosphoethanolaminyl transferase, endoplasmic reticulum

metaM tym c
is: SBO:0000247
name: tyraminium
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C8H12NO CHARGE: 1 INCHI: InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2/p+1 EHMN_ABBREVIATION: C00483
is: CHEBI:327995
initial amount: NaN
boundary condition: false
is: HMDB00306
has only substance units: false

metaM glyc3p x
initial concentration: 1.0
is: CHEBI:57597
initial amount: NaN
is: C00093
boundary condition: false
constant: false
type: Species
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: HMDB00126
name: Glycerol 3-phosphate
is: SBO:0000247
has only substance units: false

metaM dpcoa c
is: CHEBI:57328
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
is: C00882
name: Dephospho-CoA
constant: false
is: HMDB01373
has only substance units: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882

metaM cholcoa r
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
type: Species
has only substance units: false
boundary condition: false
is: HMDB01374
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57373
name: choloyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110025#_79ec3500_b5df_4b69_9956_80cd98fa38b3
type: Species
constant: false
name: _U52111_1_c
is encoded by: hsa:U52111
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true

metaM apoC m
has only substance units: false
name: Apocarboxlase (no lys residue)
constant: false
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:32551
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: XH CHARGE: 0
is: HMDB00182

metaR AACTtm
product: MODEL1310110025#
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
type: Reaction
name: Aminoacetone transport (mitochondrial)

http://identifiers.org/biomodels.db/MODEL1310110025#_f6675d36_1301_4dcf_bba4_92428c97ef54
constant: false
is: D3DX95
initial amount: NaN
is encoded by: hsa:1103
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: CHAT
has only substance units: false
type: Species

metaM tdcoa m
is: CHEBI:57385
initial concentration: 1.0
boundary condition: false
is: HMDB01521
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
has only substance units: false
is: C02593
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
name: Tetradecanoyl-CoA (n-C14:0CoA)

metaR r0393
reversible: false
reactant: MODEL1310110025#
fast: false
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
type: Reaction
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.7.1.74
product: MODEL1310110025#
is: SBO:0000176
kinetic law: MODEL1310110025#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110025#_a37b935e_df41_4649_9f71_415a5c16e512
initial concentration: NaN
is: Q3MHC9
initial amount: NaN
is: SBO:0000252
name: SKIV2L2
boundary condition: true
is encoded by: hsa:23517
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_a94d87a6_ebf6_4a44_a0f3_e7d35e6b1b5c
has only substance units: false
type: Species
constant: false
is encoded by: hsa:92483
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: Q9BYZ2
name: LDHAL6B
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_d0daf2d2_0842_490e_bdd5_f364c70fe5dd
name: AMY1C
boundary condition: true
is encoded by: hsa:278
is: P04745
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
has only substance units: false

metaR INSTt4
kinetic law: MODEL1310110025#
name: inositol transport via sodium symport
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD
type: Reaction
reactant: MODEL1310110025#
fast: false
is: SBO:0000185
modifier: MODEL1310110025#
product: MODEL1310110025#
reversible: true
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110025#_e094d0f8_0a73_4f04_a386_7dec013c742f
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:23556
constant: false
name: PIGN
initial amount: NaN
type: Species
boundary condition: true

metaR ACHtn
is described by: ECO:0000000
product: MODEL1310110025#
reversible: true
fast: false
reactant: MODEL1310110025#
is: SBO:0000185
type: Reaction
name: Acetylcholin transport, nuclear trhough pores
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
kinetic law: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_9c22b6f9_5866_441e_abdd_7b33598e1371
is: P48448
initial concentration: NaN
constant: false
is encoded by: hsa:222
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
name: ALDH3B2

metaR CSNATp
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
is described by: ECO:0000304
fast: false
reversible: true
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.7
product: MODEL1310110025#
name: carnitine O-acetyltransferase, reverse direction, peroxisomal
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:7829107 NOTES:NCD

metaM 3sala c
boundary condition: false
initial concentration: 1.0
type: Species
name: 3-Sulfino-L-alanine
is: SBO:0000247
notes: FORMULA: C3H5NO4S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
is: C00606
is: CHEBI:61085
initial amount: NaN
has only substance units: false
constant: false

metaM dgchol x
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:36252
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
initial amount: NaN
name: glycochenodeoxycholate
boundary condition: false
type: Species
is: HMDB00637
is: SBO:0000247

metaR r1666
reactant: MODEL1310110025#
modifier: MODEL1310110025#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110025#
is described by: ECO:0000000
kinetic law: MODEL1310110025#
name: Y+LAT2 Utilized transport
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110025#_7b564a44_d6e0_4c3d_ad88_e6ad2ac2c3f8
name: IDH1
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3417
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is: O75874

metaM rbt e
initial amount: NaN
constant: false
is: SBO:0000247
name: D-ribitol
type: Species
initial concentration: 1.0
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
has only substance units: false
is: CHEBI:15963
is: HMDB00508
boundary condition: false

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_68d6303a_4538_4d64_9d52_25d9e9b89eac
is encoded by: hsa:221823
initial amount: NaN
type: Species
name: PRPS1L1
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
is: P21108

metaR XOLTRIOLtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
kinetic law: MODEL1310110025#
product: MODEL1310110025#
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
name: lipid, flip-flop intracellular transport
reactant: MODEL1310110025#
reversible: true

metaM 3mob m
boundary condition: false
name: 3-methyl-2-oxobutanoate
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:11851
is: HMDB00019
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_33302c4b_bdee_4f77_96e8_acf00a537a93
type: Species
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:2766
name: GMPR
is: SBO:0000252
initial amount: NaN
is: P36959

http://identifiers.org/biomodels.db/MODEL1310110025#_12a3fa46_1e2b_4efc_97e4_15453196c7e7
initial amount: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:8883
name: NAE1
is: SBO:0000252
initial concentration: NaN
is: A8MU28

metaM 4abut e
initial concentration: 1.0
constant: false
has only substance units: false
name: 4-Aminobutanoate
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C4H9NO2 CHARGE: 0
is: HMDB00112
is: C00334
type: Species
is: CHEBI:3628
boundary condition: false

metaR r0669
fast: false
product: MODEL1310110025#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_c276caef_c69c_4045_bf47_bac99abc8827
type: Species
constant: false
is: P11086
has only substance units: false
is encoded by: hsa:5409
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: PNMT

metaR r1665
product: MODEL1310110025#
kinetic law: MODEL1310110025#
is: SBO:0000185
modifier: MODEL1310110025#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110025#
name: Y+LAT2 Utilized transport
reversible: true
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110025#_79240062_eea9_4158_9aa5_ab9092cc9b1c
constant: false
is: Q15738
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:50814
type: Species
boundary condition: true
name: NSDHL
initial amount: NaN

metaM cholp c
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
constant: false
name: choline phosphate(1-)
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:295975
initial concentration: 1.0

metaM cholate e
is: HMDB00619
boundary condition: false
initial concentration: 1.0
is: CHEBI:29747
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: Cholate
constant: false

metaR r0242
modifier: MODEL1310110025#
fast: false
reversible: true
reactant: MODEL1310110025#
product: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.1
is described by: ECO:0000000
kinetic law: MODEL1310110025#
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1

http://identifiers.org/biomodels.db/MODEL1310110025#_0ccd0903_3c9a_4df4_bd2b_1822ea2879d4
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: P30613
initial concentration: NaN
is encoded by: hsa:5313
type: Species
name: PKLR

metaR SERDGLYexR
reactant: MODEL1310110025#
reversible: true
fast: false
product: MODEL1310110025#
type: Reaction
kinetic law: MODEL1310110025#
is described by: ECO:0000304
name: D-Serine/Glycine reversible exchange
is: SBO:0000185
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

metaR r1668
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110025#
fast: false
type: Reaction
product: MODEL1310110025#
reversible: true
reactant: MODEL1310110025#
modifier: MODEL1310110025#

metaR O2tp
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110025#
is: SBO:0000185
product: MODEL1310110025#
fast: false
type: Reaction
name: O2 transport, peroxisomal

metaR HESTRATRIOLte
type: Reaction
fast: false
reactant: MODEL1310110025#
reversible: true
is: SBO:0000185
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, hydroxylated (inactivated) estrogen derivative needs to be exported NJ
name: hydroxylated estrogen derivative transport
kinetic law: MODEL1310110025#
is described by: ECO:0000000

metaR 2AMADPTm
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
reversible: true
is described by: ECO:0000269
product: MODEL1310110025#
type: Reaction
kinetic law: MODEL1310110025#
is: SBO:0000185
name: L-2-aminoadipate shuttle (cytosol/mitochondria)
reactant: MODEL1310110025#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110025#_1a213b98_c2c7_4a9a_bf68_be3e879602ab
is: E7EPT3
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:501
name: ALDH7A1
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_f38e228f_3808_4212_a09a_48d4e1f6eb5a
type: Species
is: SBO:0000252
name: SLC2A2
initial amount: NaN
is encoded by: hsa:6514
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is: P11168

http://identifiers.org/biomodels.db/MODEL1310110025#_b1a0703d_0153_4575_8ce0_2fa76815bc7d
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:3030
name: HADHA
boundary condition: true
has only substance units: false
is: E9KL44
initial amount: NaN

metaR EX thymd LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymidine exchange
type: Reaction

metaM HC00718 c
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:57781
name: N-methylethanolaminium phosphate(1-)
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1

metaM gal l
boundary condition: false
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124
is: HMDB00143
is: CHEBI:12936
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: D-galactose

metaR r0434
is: SBO:0000176
fast: false
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
is described by: ECO:0000000
product: MODEL1310110025#
kinetic law: MODEL1310110025#
reversible: true
modifier: MODEL1310110025#
reactant: MODEL1310110025#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_3de275e0_1ef5_48fe_b91b_ba442a9ed8f4
is encoded by: hsa:6522
has only substance units: false
is: F8W682
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
name: SLC4A2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_57b15d08_1606_4be5_8f76_e06330edc20d
is: SBO:0000252
initial concentration: NaN
name: SLC15A2
boundary condition: true
type: Species
is encoded by: hsa:6565
constant: false
has only substance units: false
is: Q16348
initial amount: NaN

metaM ppcoa x
is: CHEBI:57392
type: Species
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: C00100
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB01275
name: Propanoyl-CoA

metaR ACALDt
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
product: MODEL1310110025#
name: acetaldehyde reversible transport
reversible: true
is described by: ECO:0000000
fast: false
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#

metaM pe hs e
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:16038
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
name: phosphatidylethanolamine

http://identifiers.org/biomodels.db/MODEL1310110025#_8e392748_f283_4921_9611_e0f3ffa3c4bd
is encoded by: hsa:57194
is: O60312
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
name: ATP10A
is: SBO:0000252

metaR r1667
type: Reaction
is: SBO:0000185
reversible: true
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
name: Y+LAT2 Utilized transport
fast: false
product: MODEL1310110025#
is described by: ECO:0000000
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR RE2079R
reversible: true
product: MODEL1310110025#
type: Reaction
reactant: MODEL1310110025#
is described by: ECO:0000000
fast: false
is: SBO:0000176
name: RE2079
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110025#_02b6c940_4367_4866_8b79_dec4cbd9df44
is: P14550
initial concentration: NaN
initial amount: NaN
name: AKR1A1
is encoded by: hsa:10327
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
constant: false

metaR ADSS
modifier: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
name: adenylosuccinate synthase
fast: false
kinetic law: MODEL1310110025#
is: SBO:0000176
reversible: false
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/6.3.4.4
is described by: ECO:0000134
reactant: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_dc9336da_a268_4d61_9eb7_551edadc8fc0
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: P30084
constant: false
name: ECHS1
is encoded by: hsa:1892
type: Species
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110025#_de5bce38_1af2_47fa_9a09_585881136f62
initial amount: NaN
constant: false
is: P08236
is: SBO:0000252
name: GUSB
initial concentration: NaN
is encoded by: hsa:2990
boundary condition: true
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_5899cf05_821d_445f_bdab_a297cc1ebdbf
boundary condition: true
type: Species
initial concentration: NaN
is: Q1LZ56
is encoded by: hsa:206358
has only substance units: false
name: SLC36A1
constant: false
initial amount: NaN
is: SBO:0000252

metaR HSD3A1r
is version of: http://identifiers.org/ec-code/1.1.1.225
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110025#
product: MODEL1310110025#
kinetic law: MODEL1310110025#
is: SBO:0000176
fast: false
modifier: MODEL1310110025#
reversible: true
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)

metaR FACOAL2042
reversible: true
type: Reaction
fast: false
name: fatty-acid--CoA ligase
reactant: MODEL1310110025#
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA alternate to arachidonic acid (n-3 rather than n-6) NJ
product: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_c6579778_519b_486a_8d4f_12c98f6e4a01
is: O95168
boundary condition: true
name: NDUFB4
is encoded by: hsa:4710
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaM coa n
name: coenzyme A(4-)
initial amount: NaN
boundary condition: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: SBO:0000247
type: Species
constant: false
is: HMDB01423
is: CHEBI:57287
has only substance units: false
initial concentration: 1.0

metaR RE2426C
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12044950 NOTES:
product: MODEL1310110025#
reversible: true
kinetic law: MODEL1310110025#
is: SBO:0000176
name: RE2426
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110025#

metaR r0246
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.5.1.3
modifier: MODEL1310110025#
reactant: MODEL1310110025#
reversible: false
kinetic law: MODEL1310110025#
fast: false
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:

metaM adrncoa c
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205480
boundary condition: false
initial concentration: 1.0
name: adrenyl coenzyme A
is: SBO:0000247
type: Species
is: C16170
initial amount: NaN

metaM leuktrE4 e
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
is: HMDB02200
initial amount: NaN
constant: false
is: CHEBI:57462
initial concentration: 1.0
name: leukotriene E4(1-)
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false

metaR RE2677E
is described by: ECO:0000000
kinetic law: MODEL1310110025#
name: RE2677
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:IT - fixed proton
fast: false
reactant: MODEL1310110025#
is: SBO:0000176
product: MODEL1310110025#
reversible: false

metaR EX sprm LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_sprm(e)
type: Reaction

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

W3 CDTF: Fri Aug 31 00:59:05 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110025#_5a6e95b6_891c_4386_b74d_b461a96c8668
is: Q99808
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
name: SLC29A1
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:2030

metaR FBA
fast: false
reversible: true
name: fructose-bisphosphate aldolase
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/4.1.2.13
type: Reaction
modifier: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000134
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (230.1) or (229.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:12626877,PMID:6765112 NOTES:6765112 - fluorescence of presence in human brain
is: SBO:0000176

metaM coa m
has only substance units: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: C00010
is: HMDB01423
is: CHEBI:57287
initial amount: NaN
initial concentration: 1.0
name: Coenzyme A
is: SBO:0000247
type: Species
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110025#_1911c479_8538_410e_8be7_ee87d19be36c
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: AK2
is: P54819
initial concentration: NaN
type: Species
is encoded by: hsa:204
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110025#_09e46899_9708_4f2c_b69d_c805f8b1b2f4
boundary condition: true
has part: Q9UHI5
constant: false
is: SBO:0000297
name: SLC7A8:SLC3A2
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:23428
has only substance units: false

metaR r0245
modifier: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
type: Reaction
kinetic law: MODEL1310110025#
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110025#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.3

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

metaR r1981
reactant: MODEL1310110025#
modifier: MODEL1310110025#
product: MODEL1310110025#
name: Y+LAT2 Utilized transport
reversible: false
fast: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110025#
type: Reaction

metaR r0210
product: MODEL1310110025#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110025#
fast: false
reversible: false
name: L-Serine hydro-lyase (adding homocysteine) Glycine, serine and threonine metabolism EC:4.2.1.22
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 4.2.1.22 Confidence Level: 0 AUTHORS: PMID:681363 NOTES:
kinetic law: MODEL1310110025#

metaM odecoa c
initial amount: NaN
name: Octadecenoyl-CoA (n-C18:1CoA)
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
type: Species
has only substance units: false
is: HMDB01322
is: CHEBI:3793

metaR r1378
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
is described by: ECO:0000000
reactant: MODEL1310110025#
type: Reaction
fast: false
product: MODEL1310110025#
kinetic law: MODEL1310110025#

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

metaR RE3568C
reactant: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is described by: ECO:0000000
name: RE3568
kinetic law: MODEL1310110025#
product: MODEL1310110025#
type: Reaction
reversible: true
is: SBO:0000176

metaM 5adtststerone e
is: SBO:0000247
is: CHEBI:16330
name: 17beta-hydroxy-5alpha-androstan-3-one
boundary condition: false
initial amount: NaN
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
constant: false
has only substance units: false
is: HMDB02961
initial concentration: 1.0
type: Species

metaM dgtp c
boundary condition: false
is: CHEBI:16497
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
type: Species
is: C00286
initial concentration: 1.0
constant: false
is: HMDB01440
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: dGTP

http://identifiers.org/biomodels.db/MODEL1310110025#_af93fed7_4589_4deb_b048_761612e98d89
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
name: _H17063_1_c
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:H17063
constant: false

metaM val L m
is: HMDB00883
initial concentration: 1.0
name: L-valine
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:16414
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
boundary condition: false
has only substance units: false

metaR PIter
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
type: Reaction
name: phosphate transport, endoplasmic reticulum
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
product: MODEL1310110025#
is described by: ECO:0000212
reversible: true
modifier: MODEL1310110025#
is: SBO:0000185
fast: false

metaM cholate r
is: HMDB00619
is: SBO:0000247
name: cholate
initial concentration: 1.0
type: Species
notes: FORMULA: C24H39O5 CHARGE: -1 INCHI: InChI=1S/C24H40O5/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29)/p-1/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:29747
boundary condition: false

metaR r0973
product: MODEL1310110025#
is described by: ECO:0000000
reversible: true
fast: false
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
name: Facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
is: SBO:0000185
type: Reaction

W3 CDTF: Fri Aug 31 00:59:05 BST 2012

metaM ala B e
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB00056
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
constant: false
initial amount: NaN
name: beta-alanine
boundary condition: false
is: CHEBI:16958

http://identifiers.org/biomodels.db/MODEL1310110025#_cac1ced2_786b_4d9a_96eb_b687a38fac1a
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2182
boundary condition: true
is: Q5JWV8
type: Species
has only substance units: false
name: ACSL4
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_4ecd2299_c06e_4a4a_950e_6efb1b81f35e
constant: false
is encoded by: hsa:1633
name: DCK
type: Species
boundary condition: true
has only substance units: false
is: P27707
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaM tyr L c
is: HMDB00158
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: L-tyrosine
is: CHEBI:17895
has only substance units: false
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085

metaR r0974
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
is: SBO:0000185
product: MODEL1310110025#
is described by: ECO:0000000
fast: false
name: Active transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
reversible: true

metaM arachcoa m
is: SBO:0000247
is: CHEBI:15527
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
name: arachidyl coenzyme A
boundary condition: false
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: HMDB04258
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110025#_ca4054b9_ea76_4c4c_8f5d_25eccc39ed23
initial amount: NaN
is encoded by: hsa:4700
is: P56556
constant: false
boundary condition: true
initial concentration: NaN
name: NDUFA6
has only substance units: false
is: SBO:0000252
type: Species

metaR r0022
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
modifier: MODEL1310110025#
is described by: ECO:0000000
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
kinetic law: MODEL1310110025#
reversible: true
type: Reaction
reactant: MODEL1310110025#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.7
product: MODEL1310110025#

metaM xoltriol c
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB01457
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
type: Species
initial amount: NaN
constant: false
is: CHEBI:16496
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
boundary condition: false

metaR Q10H2e
kinetic law: MODEL1310110025#
type: Reaction
name: transport of ubiquinol into lymph
is described by: ECO:0000134
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.
product: MODEL1310110025#
reactant: MODEL1310110025#
reversible: true

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_b0a72f2c_8f8d_48e8_90ba_70284a8bfdf9
constant: false
initial concentration: NaN
is encoded by: hsa:AI285872
has only substance units: false
initial amount: NaN
name: _AI285872_1_c
boundary condition: true
is: SBO:0000252
type: Species

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

metaR r0885
kinetic law: MODEL1310110025#
is: SBO:0000185
reversible: true
is version of: http://identifiers.org/ec-code/1.3.1.38
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
product: MODEL1310110025#
modifier: MODEL1310110025#
fast: false
reactant: MODEL1310110025#
type: Reaction

metaM leuktrE4 c
constant: false
is: HMDB02200
type: Species
is: SBO:0000247
boundary condition: false
name: leukotriene E4(1-)
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57462
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
has only substance units: false

metaM ppcoa c
is: SBO:0000247
is: HMDB01275
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
has only substance units: false
constant: false
is: CHEBI:57392
boundary condition: false
is: C00100
initial amount: NaN
name: Propanoyl-CoA
initial concentration: 1.0
type: Species

metaR EX ala D LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Alanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_231573a3_9025_4fbd_b22d_d860027fe5d4
name: ALDOA
constant: false
is: P04075
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:226
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_26d59ad5_a39c_4998_976d_fd1f5061d0ed
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: PIGN
is: O95427
is encoded by: hsa:23556
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110025#_eea9c783_9f20_4305_9da9_b9ee61fe38b7
boundary condition: true
name: GGT1
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2678
has only substance units: false
is: P19440
is: SBO:0000252

metaM so4 c
is: CHEBI:16189
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
name: sulfate
boundary condition: false
type: Species
initial amount: NaN
is: HMDB01448

metaM ha e
is: CHEBI:16336
initial amount: NaN
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
has only substance units: false
boundary condition: false
name: hyaluronan
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species

metaR PPCDC
reactant: MODEL1310110025#
fast: false
type: Reaction
reversible: false
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
is: SBO:0000176
is described by: ECO:0000269
name: phosphopantothenoylcysteine decarboxylase
is version of: http://identifiers.org/ec-code/4.1.1.36
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 4 AUTHORS: PMID:11923312 NOTES:

metaR RE1522M
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE1522
product: MODEL1310110025#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is: SBO:0000176
modifier: MODEL1310110025#
reactant: MODEL1310110025#

metaR DNDPt37m
type: Reaction
modifier: MODEL1310110025#
reactant: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dUTP transport via dTDP antiport
kinetic law: MODEL1310110025#
is described by: ECO:0000269
is: SBO:0000185
reversible: false
fast: false

metaR RPI
product: MODEL1310110025#
name: ribose-5-phosphate isomerase
type: Reaction
modifier: MODEL1310110025#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
kinetic law: MODEL1310110025#
fast: false
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/5.3.1.6
is described by: ECO:0000000

metaR ABUTt2r
is: SBO:0000185
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r
fast: false
kinetic law: MODEL1310110025#
reversible: true
name: 4-aminobutyrate reversible transport in via proton symport
is described by: ECO:0000304
type: Reaction
modifier: MODEL1310110025#
product: MODEL1310110025#

metaR r0021
product: MODEL1310110025#
reactant: MODEL1310110025#
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110025#
is version of: http://identifiers.org/ec-code/3.6.1.5
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton

http://identifiers.org/biomodels.db/MODEL1310110025#_db755b1b_4e64_4706_9814_6b9a660e6783
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: _AI620219_1_c
constant: false
is encoded by: hsa:AI620219
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_b99dea78_9e1c_424c_b997_c05387c5d90d
type: Species
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:FLJ44968
name: _FLJ44968_1_m

metaR r1983
reversible: false
kinetic law: MODEL1310110025#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110025#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110025#

metaR METS
product: MODEL1310110025#
reversible: false
name: methionine synthase
is: SBO:0000176
kinetic law: MODEL1310110025#
modifier: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: (4548.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.1.1.13 Confidence Level: 4 AUTHORS: PMID:8968736,PMID:9013615 NOTES:Human Y/N: Y
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.1.1.13
is described by: ECO:0000134
type: Reaction

metaM btcoa m
initial concentration: 1.0
initial amount: NaN
constant: false
name: Butanoyl-CoA
type: Species
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
has only substance units: false
boundary condition: false
is: C00136
is: CHEBI:57371
is: HMDB01088
is: SBO:0000247

metaM HC01399 m
notes: FORMULA: C35H58N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-24,28-30,34,43,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t23-,24+,28+,29+,30-,34+/m0/s1 EHMN_ABBREVIATION: C05260
boundary condition: false
initial amount: NaN
name: (S)-3-Hydroxytetradecanoyl-CoA
has only substance units: false
constant: false
type: Species
is: CHEBI:27466
initial concentration: 1.0
is: SBO:0000247

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

metaR r1418
is described by: ECO:0000000
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
product: MODEL1310110025#
fast: false
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
is: SBO:0000176
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110025#_4a1d98ed_d9a0_41ab_a72b_0f425c2f5e07
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:BE966236
name: _BE966236_1_c

metaM HC01376 m
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-3-10(2)13(16)18-9-8-11(17)6-4-5-7-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05118
is: CHEBI:28692
constant: false
type: Species
has only substance units: false
name: S-(2-Methylbutanoyl)-dihydrolipoamide

http://identifiers.org/biomodels.db/MODEL1310110025#_7e2afa31_6966_4244_a63a_61b8986951f2
initial amount: NaN
name: OGDHL
initial concentration: NaN
constant: false
is: Q9ULD0
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:55753

metaM CE5119 m
initial amount: NaN
boundary condition: false
type: Species
name: trans-3-cis-8-tetradecadienoyl-CoA
has only substance units: false
constant: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119
is: CHEBI:12947
initial concentration: 1.0
is: SBO:0000247

metaR CSNATr
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:7829107 NOTES:IF
name: carnitine O-acetyltransferase
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110025#
is: SBO:0000176
product: MODEL1310110025#
type: Reaction
reactant: MODEL1310110025#

metaM gthrd e
is: CHEBI:57925
has only substance units: false
initial concentration: 1.0
is: HMDB00125
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
name: glutathionate(1-)
type: Species
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051

metaR EX 3aib D LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-3-Amino-isobutanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_862ae706_2882_4b7f_92aa_9e5f46e53a57
type: Species
is: SBO:0000252
is: P22413
initial amount: NaN
is encoded by: hsa:5167
name: ENPP1
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN

metaM ala B c
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
is: SBO:0000247
name: beta-alanine
is: HMDB00056
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:16958

metaM lnlccoa m
constant: false
is: SBO:0000247
name: linoleic coenzyme A
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
is: HMDB01064
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/5462164

metaM CE2705 n
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB02281
name: quinonoid dihydrobiopterin
is: CHEBI:15374
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN

metaR EX hestratriol LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4,17 dihydroxy estradiol exchange
type: Reaction

metaM lnlncgcoa c
type: Species
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB06368
constant: false
initial concentration: 1.0
name: gamma-linolenoyl-CoA(4-)
initial amount: NaN
is: CHEBI:57363

metaR CYTK9n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
reversible: true
name: cytidylate kinase (CMP,dCTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
kinetic law: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000269
reactant: MODEL1310110025#
fast: false
modifier: MODEL1310110025#

metaR LACZe
fast: false
reactant: MODEL1310110025#
reversible: false
notes: GENE_ASSOCIATION: (3938.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:5774109 NOTES:Some enzymes in this group hydrolyse a-L-arabinosides; some animal enzymes also hydrolyse b-D-fucosides and b-D-glucosides; cf. EC 3.2.1.108 lactase
is: SBO:0000176
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/3.2.1.108
is described by: ECO:0000134
type: Reaction
name: b-galactosidase, extracellular
product: MODEL1310110025#
kinetic law: MODEL1310110025#

metaM gln L c
boundary condition: false
constant: false
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: HMDB00641
initial concentration: 1.0
name: L-glutamine
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:18050
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_03376d9e_5c13_402f_a6ce_93edf11643cb
is encoded by: hsa:60490
type: Species
is: Q96CD2
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
name: PPCDC
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_029e92d9_09d5_4632_b8d9_fca24ccdfd1e
type: Species
boundary condition: true
constant: false
is encoded by: hsa:158
initial amount: NaN
name: ADSL
is: SBO:0000252
has only substance units: false
is: P30566
initial concentration: NaN

metaR r1901
reactant: MODEL1310110025#
fast: false
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110025#
is: SBO:0000185
kinetic law: MODEL1310110025#
reversible: false
is described by: ECO:0000000
type: Reaction
name: Y+LAT2 Utilized transport

metaM cbasp e
initial amount: NaN
is: SBO:0000247
name: N-Carbamoyl-L-aspartate
is: C00438
constant: false
is: CHEBI:32814
has only substance units: false
is: HMDB00828
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H6N2O5 CHARGE: -2

metaR VITD3t2
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is taken up from peripheral cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
name: Vitamin D3 uptake
fast: false
product: MODEL1310110025#

metaR PPNCL3
notes: GENE_ASSOCIATION: (79717.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/6.3.2.5
product: MODEL1310110025#
type: Reaction
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
name: phosphopantothenate-cysteine ligase
is described by: ECO:0000269
modifier: MODEL1310110025#
is: SBO:0000176

metaM pi e
type: Species
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB00973
initial amount: NaN
name: hydrogenphosphate
is: C00009
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial concentration: 1.0
has only substance units: false
is: CHEBI:43474

metaR DOLPMT3 Uer
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
fast: false
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.4.1.260

http://identifiers.org/biomodels.db/MODEL1310110025#_80900175_3a29_4e86_a927_7dee75fc1737
name: ADH1B
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:125
is: P00325
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_efb91f20_b7ec_4d25_9e13_fbe64eee3050
initial amount: NaN
name: UROC1
constant: false
type: Species
boundary condition: true
is encoded by: hsa:131669
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: Q68CJ7

metaR RE3272N
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110025#
reactant: MODEL1310110025#
reversible: true
fast: false
name: RE3272
type: Reaction

metaR RNDR3
is: SBO:0000176
reactant: MODEL1310110025#
product: MODEL1310110025#
kinetic law: MODEL1310110025#
type: Reaction
is version of: http://identifiers.org/ec-code/1.17.4.1
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 4 AUTHORS: PMID:14729598 NOTES:
is described by: ECO:0000269
name: ribonucleoside-diphosphate reductase (CDP)
reversible: false
modifier: MODEL1310110025#
fast: false

ORG:
  orgname: University of Manchester
n:
  given: Neil
  family: Swainston

metaM gthrd c
initial concentration: 1.0
type: Species
is: CHEBI:57925
is: HMDB00125
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
boundary condition: false
is: SBO:0000247
name: Reduced glutathione
initial amount: NaN
is: C00051
constant: false
has only substance units: false

metaR BALAtmr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
is described by: ECO:0000000
product: MODEL1310110025#
kinetic law: MODEL1310110025#
name: Beta-alanine reversible mitochondrial transport (diffusion)
reversible: true
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_89660fa3_8b57_4dd7_8129_6c6d58150e39
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1040
has only substance units: false
name: CDS1
type: Species
constant: false
is: SBO:0000252
is: Q92903
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_1464bf95_e352_4560_9ecb_ab06f079d5a0
initial amount: NaN
boundary condition: true
is encoded by: hsa:2348
initial concentration: NaN
name: FOLR1
type: Species
has only substance units: false
constant: false
is: SBO:0000252

metaM gln L e
is: HMDB00641
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
name: L-glutamine
is: SBO:0000247
is: CHEBI:18050
type: Species
has only substance units: false
constant: false

metaR r1377
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176
fast: false
reversible: true
product: MODEL1310110025#
is described by: ECO:0000000
type: Reaction
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
kinetic law: MODEL1310110025#

metaR CYTK1m
product: MODEL1310110025#
type: Reaction
kinetic law: MODEL1310110025#
fast: false
name: cytidylate kinase (CMP),mitochondrial
reversible: true
is described by: ECO:0000134
reactant: MODEL1310110025#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:No evidence in the mitochondrion

metaR ALADGLNexR
product: MODEL1310110025#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
name: L-alanine/glutamine reversible exchange
reversible: true
type: Reaction
is: SBO:0000185
modifier: MODEL1310110025#
fast: false
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_ffe503b4_5d14_422c_9c25_71981d446f37
initial concentration: NaN
name: CA13
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:377677
type: Species
constant: false
is: Q8N1Q1

metaM mi1p D c
initial amount: NaN
name: 1D-myo-inositol 1-phosphate(2-)
type: Species
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
is: HMDB02985
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:58433
boundary condition: false
is: SBO:0000247

metaM oaa c
is: CHEBI:3338
initial concentration: 1.0
constant: false
notes: FORMULA: C4H2O5 CHARGE: -2
type: Species
is: SBO:0000247
is: HMDB00223
name: Oxaloacetate
boundary condition: false
initial amount: NaN
has only substance units: false
is: C00036

metaM met L c
has only substance units: false
boundary condition: false
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:16643
is: HMDB00696
name: L-methionine
initial amount: NaN
constant: false

metaR RNDR1
fast: false
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
name: ribonucleoside-diphosphate reductase (ADP)
type: Reaction
reversible: false
kinetic law: MODEL1310110025#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.17.4.1
product: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000254

http://identifiers.org/biomodels.db/MODEL1310110025#_0cf858dd_8447_455a_9aec_eaf6d77237a8
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:6548
constant: false
initial concentration: NaN
has only substance units: false
is: P19634
name: SLC9A1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_93ae9d7d_c7c7_47a3_9227_881dde56f20a
has only substance units: false
is: SBO:0000297
name: VNN3:VNN2:VNN1
type: Species
boundary condition: true
is encoded by: hsa:55350
initial concentration: NaN
initial amount: NaN
constant: false

metaM cbasp c
constant: false
has only substance units: false
is: C00438
notes: FORMULA: C5H6N2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00356 EHMN_ABBREVIATION: C00438
boundary condition: false
type: Species
initial amount: NaN
name: N-Carbamoyl-L-aspartate
initial concentration: 1.0
is: CHEBI:32814
is: SBO:0000247
is: HMDB00828

metaM citr L m
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB00904
is: SBO:0000247
type: Species
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
is: CHEBI:16349
has only substance units: false
name: L-citrulline

http://identifiers.org/biomodels.db/MODEL1310110025#_e1c6814a_ab81_4ade_bb88_3c3e9f738cac
is encoded by: hsa:AI926493
initial amount: NaN
name: _AI926493_1_m
type: Species
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR r0970
name: Active transport
type: Reaction
fast: false
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
is described by: ECO:0000000
reversible: true
product: MODEL1310110025#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110025#_09bb11ca_25c3_49f4_baf0_f8e2fcd76982
is: Q8N0X4
initial concentration: NaN
is encoded by: hsa:171425
name: CLYBL
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110025#_504e2948_7eed_4def_bced_fe128a4ec8fc
has only substance units: false
constant: false
initial amount: NaN
name: SLC13A3
boundary condition: true
is: Q8WWT9
initial concentration: NaN
is encoded by: hsa:64849
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_7981dae3_957d_4ebd_9924_b9b80edb49b3
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:3712
initial amount: NaN
boundary condition: true
is: B3KVI7
type: Species
initial concentration: NaN
name: IVD

metaM adn m
type: Species
is: HMDB00050
constant: false
initial amount: NaN
is: CHEBI:16335
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: adenosine
has only substance units: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 INCHI: InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212

metaR RE3004M
name: RE3004
is: SBO:0000176
reactant: MODEL1310110025#
modifier: MODEL1310110025#
product: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110025#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110025#_93f0e840_cd87_4391_809d_380e94c94e32
is: P30048
constant: false
is encoded by: hsa:10935
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: PRDX3

metaM adp n
name: ADP(3-)
initial concentration: 1.0
is: CHEBI:456216
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
constant: false
is: HMDB01341
initial amount: NaN

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

http://identifiers.org/biomodels.db/MODEL1310110025#_5b9be3f2_3e14_4808_86a6_5d4c68bfeb02
type: Species
is: P08195
boundary condition: true
name: SLC3A2
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6520
constant: false
has only substance units: false

metaR OCOAT1m
fast: false
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reactant: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: (5019.1) or (64064.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.8.3.5 Confidence Level: 4 AUTHORS: PMID:10964512,PMID:11756565 NOTES:TDV
modifier: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.8.3.5
name: 3-oxoacid CoA-transferase
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110025#_795bad14_1ea8_488c_ac12_64952c125224
is: SBO:0000252
name: DPYD
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1806
type: Species
is: Q12882
constant: false
boundary condition: true

metaR r0170
is described by: ECO:0000000
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
is: SBO:0000176
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
fast: false
product: MODEL1310110025#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.40
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
type: Reaction

metaR r1660
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110025#
is: SBO:0000185
fast: false
reversible: true
modifier: MODEL1310110025#

metaR DOLMANP Uter
product: MODEL1310110025#
kinetic law: MODEL1310110025#
is: SBO:0000185
fast: false
name: dolichol-phosphate mannose flippase (uterus)
is described by: ECO:0000000
reactant: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110025#_deee2c68_8b43_49a9_9e0e_a6bdf1317943
boundary condition: true
constant: false
type: Species
name: PYCRL
initial amount: NaN
has only substance units: false
is: Q53H96
is encoded by: hsa:65263
is: SBO:0000252
initial concentration: NaN

metaM dhap c
is: CHEBI:57642
is: http://identifiers.org/pubchem.compound/3411
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB01473
is: SBO:0000247
name: Dihydroxyacetone phosphate
is: C00111
constant: false

metaR SPHMDAc
fast: false
reactant: MODEL1310110025#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110025#
name: sphingomyelin deacylase
type: Reaction
reversible: false
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12069827 NOTES:limited details on mechanism, localization, etc. See PMID: 12069827 NJ

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_a0bfe274_f1e6_4599_b136_ba9b2084859c
is: G3V0F6
initial amount: NaN
is encoded by: hsa:8525
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
name: DGKZ
is: SBO:0000252
type: Species

metaM nad m
is: C00003
is: SBO:0000247
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/3305
initial concentration: 1.0
initial amount: NaN
name: Nicotinamide adenine dinucleotide
type: Species
is: CHEBI:57540
boundary condition: false
is: HMDB00902

metaM adp m
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/3310
is: HMDB01341
name: ADP
is: CHEBI:456216
is: C00008
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
constant: false

metaR CYTK1n
kinetic law: MODEL1310110025#
type: Reaction
is described by: ECO:0000269
reversible: true
product: MODEL1310110025#
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
reactant: MODEL1310110025#
name: cytidylate kinase (CMP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176

metaM Ser Gly Ala X Gly l
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: XH CHARGE: 0
is: HMDB06202
type: Species
name: protein-linked serine residue (glycosaminoglycan attachment site)
initial concentration: 1.0

metaM hxan c
is: SBO:0000247
boundary condition: false
is: HMDB00157
is: C00262
initial amount: NaN
type: Species
is: CHEBI:17368
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
initial concentration: 1.0
has only substance units: false
name: Hypoxanthine
constant: false

metaR r2537
name: Utilized transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110025#
is: SBO:0000185
product: MODEL1310110025#
kinetic law: MODEL1310110025#

metaR COAtp
is: SBO:0000185
name: coenzyme A transport, peroxisomal
type: Reaction
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
reactant: MODEL1310110025#
is described by: ECO:0000000
product: MODEL1310110025#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110025#_b0626410_2d50_441f_915b_696e789e9e72
initial amount: NaN
initial concentration: NaN
name: IK
is: SBO:0000252
has only substance units: false
is: Q13123
is encoded by: hsa:3550
boundary condition: true
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_8e626368_7edd_42a1_ba8d_43cce9b0b8c3
has only substance units: false
name: NDUFB11
initial amount: NaN
is: Q9NX14
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:54539
initial concentration: NaN
constant: false

metaM met L e
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
name: L-methionine
type: Species
is: CHEBI:16643
initial concentration: 1.0
is: HMDB00696
boundary condition: false

metaM fmn c
constant: false
type: Species
is: HMDB01520
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
initial amount: NaN
boundary condition: false
is: CHEBI:58210
initial concentration: 1.0
name: FMN
has only substance units: false
is: C00061
is: SBO:0000247

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

metaR LEUPHELAT2tc
kinetic law: MODEL1310110025#
product: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_f68704b9_dfab_417d_9b04_18454b816995
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:594
is: P21953
constant: false
initial concentration: NaN
initial amount: NaN
name: BCKDHB

metaR OCDCEAtr
product: MODEL1310110025#
type: Reaction
kinetic law: MODEL1310110025#
name: fatty acid transport via diffusion
reversible: true
reactant: MODEL1310110025#
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

metaR r0730
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reversible: false
is: SBO:0000176
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
kinetic law: MODEL1310110025#
product: MODEL1310110025#
modifier: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110025#_0a04dc1b_e746_4b86_99c3_827e55b22bd1
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
name: SLC6A10P
has only substance units: false
initial concentration: NaN
is encoded by: hsa:386757
boundary condition: true

metaM lnlc e
name: linoleate
is: CHEBI:30245
type: Species
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB00673
constant: false
initial concentration: 1.0

metaR DCMPDA
is version of: http://identifiers.org/ec-code/3.5.4.12
product: MODEL1310110025#
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
modifier: MODEL1310110025#
is: SBO:0000176
name: dCMP deaminase
type: Reaction
is described by: ECO:0000254
fast: false
reactant: MODEL1310110025#
reversible: true

metaR SO4t4 2
product: MODEL1310110025#
reactant: MODEL1310110025#
modifier: MODEL1310110025#
is described by: ECO:0000269
name: sulfate transport via sodium symport
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
reversible: true
fast: false
type: Reaction
is: SBO:0000185

metaM ppcoa m
is: CHEBI:57392
name: Propanoyl-CoA
has only substance units: false
is: SBO:0000247
is: C00100
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: HMDB01275
initial amount: NaN
type: Species
constant: false
boundary condition: false
initial concentration: 1.0

metaR r2391
is: SBO:0000185
reversible: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110025#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110025#
fast: false
reactant: MODEL1310110025#

metaM dgchol c
is: HMDB00637
is: SBO:0000247
constant: false
name: glycochenodeoxycholate
initial amount: NaN
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:36252

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

metaM ipdp x
boundary condition: false
has only substance units: false
is: HMDB01347
is: SBO:0000247
type: Species
is: CHEBI:128769
initial concentration: 1.0
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
initial amount: NaN
constant: false
name: isopentenyl diphosphate(3-)

http://identifiers.org/biomodels.db/MODEL1310110025#_e7c5a8fe_bf27_4617_9a01_2e7a42aad81c
constant: false
is: O60427
name: FADS1
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:3992

metaR r0509
kinetic law: MODEL1310110025#
name: Succinate:ubiquinone oxidoreductase Citrate cycle (TCA cycle) EC:1.3.5.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: 1.3.5.1 Confidence Level: 0 AUTHORS: PMID:2843227 NOTES:
reactant: MODEL1310110025#
type: Reaction
fast: false
is: SBO:0000176
reversible: false
product: MODEL1310110025#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110025#_7fdb8b2c_961d_49dc_916c_92629f2b090d
boundary condition: true
type: Species
is encoded by: hsa:314
is: O75106
constant: false
initial concentration: NaN
name: AOC2
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaM fmn e
is: C00061
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB01520
boundary condition: false
type: Species
is: CHEBI:58210
name: FMN
notes: FORMULA: C17H19N4O9P CHARGE: -2

metaM val L e
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: SBO:0000247
is: HMDB00883
has only substance units: false
is: CHEBI:16414
initial concentration: 1.0
boundary condition: false
name: L-valine
type: Species
initial amount: NaN
constant: false

metaM atp e
has only substance units: false
type: Species
name: ATP(4-)
is: C00002
constant: false
is: CHEBI:57299
initial concentration: 1.0
boundary condition: false
is: HMDB00538
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110025#_b029c3d9_4041_4388_b163_a55d207bb40d
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5151
name: PDE8A
type: Species
constant: false
boundary condition: true

metaR GAMt1r
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6513.1) or (6517.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:
name: glucosamine transport (uniport)
type: Reaction
reactant: MODEL1310110025#
product: MODEL1310110025#
is: SBO:0000185
modifier: MODEL1310110025#
reversible: true
kinetic law: MODEL1310110025#
fast: false

metaM dhap e
type: Species
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
name: glycerone phosphate(2-)
initial concentration: 1.0
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
is: HMDB01473
is: CHEBI:57642
has only substance units: false

metaM CE2705 c
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
type: Species
initial amount: NaN
has only substance units: false
is: HMDB02329
is: SBO:0000247
boundary condition: false
constant: false
name: quinonoid dihydrobiopterin
is: CHEBI:30623
initial concentration: 1.0

metaR LEUt5m
kinetic law: MODEL1310110025#
reversible: true
is described by: ECO:0000000
type: Reaction
name: leucine mitochondrial transport
reactant: MODEL1310110025#
product: MODEL1310110025#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
fast: false

http://identifiers.org/biomodels.db/MODEL1310110025#_b729aa30_a034_411a_b5af_203f21d61960
is: Q9UEF7
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
constant: false
is encoded by: hsa:9365
is: SBO:0000252
name: KL

http://identifiers.org/biomodels.db/MODEL1310110025#_450d52a7_3f6b_464b_910c_6905419062f9
name: ELOVL4
is encoded by: hsa:6785
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
is: Q9GZR5

http://identifiers.org/biomodels.db/MODEL1310110025#_db82cdd7_b777_43a6_a179_8f600152f27d
type: Species
initial amount: NaN
name: PDE4C
constant: false
has only substance units: false
is: Q7KYS4
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5143

metaR G6PDH2rer
fast: false
modifier: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:NCD
is: SBO:0000176
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
is described by: ECO:0000269
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.47

metaR r0731
is described by: ECO:0000000
reversible: false
fast: false
kinetic law: MODEL1310110025#
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reactant: MODEL1310110025#
is: SBO:0000176
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_f7800c04_8f45_49ef_890d_407354159b0e
has only substance units: false
is: O75521
initial amount: NaN
is: SBO:0000252
name: ECI2
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:10455

metaM pe hs r
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false
is: CHEBI:16038
type: Species
is: SBO:0000247
name: phosphatidylethanolamine
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0

metaM nad c
is: HMDB00902
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:57540
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3305
is: C00003
name: Nicotinamide adenine dinucleotide
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_606eb7bc_0f1c_4b2c_86bc_1bd59a7cf206
initial amount: NaN
has only substance units: false
is: P05062
is: SBO:0000252
is encoded by: hsa:229
name: ALDOB
boundary condition: true
constant: false
initial concentration: NaN
type: Species

metaM mhista c
is: CHEBI:58600
name: N(tele)-methylhistaminium
is: SBO:0000247
boundary condition: false
notes: FORMULA: C6H12N3 CHARGE: 1 INCHI: InChI=1S/C6H11N3/c1-9-4-6(2-3-7)8-5-9/h4-5H,2-3,7H2,1H3/p+1 EHMN_ABBREVIATION: C05127
is: HMDB00898
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false

metaR EX lcts LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Lactose exchange
type: Reaction

metaR EX ptrc LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 1,4-butanediammonium
type: Reaction

metaR r0732
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
kinetic law: MODEL1310110025#
is described by: ECO:0000000
reactant: MODEL1310110025#
reversible: false
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
type: Reaction
product: MODEL1310110025#
fast: false

metaR COAtn
name: coenzyme A transport, nuclear
product: MODEL1310110025#
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaM hxan e
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:17368
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
name: hypoxanthine
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB00157

http://identifiers.org/biomodels.db/MODEL1310110025#_d3029cb1_3af7_4300_bf69_a4455f8a68d1
has only substance units: false
is: P13995
constant: false
name: MTHFD2
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:10797
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_e3097231_d593_41c4_bc44_6466ed0330d3
is: SBO:0000252
is: P11498
initial concentration: NaN
name: PC
constant: false
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:5091

http://identifiers.org/biomodels.db/MODEL1310110025#_6d9c9585_40c5_4357_b532_b20e5f58e1ed
name: SRD5A2
boundary condition: true
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: P31213
is encoded by: hsa:6716
initial concentration: NaN
is: SBO:0000252

metaM pi r
is: HMDB00973
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: hydrogenphosphate
is: SBO:0000247
is: CHEBI:43474
is: C00009
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
type: Species
constant: false
initial amount: NaN

metaM 4hglusa m
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938
is: CHEBI:27809
name: L-4-hydroxyglutamic semialdehyde
is: HMDB06556
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
constant: false

metaR NDPK3m
fast: false
is: SBO:0000176
reversible: true
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
type: Reaction
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
product: MODEL1310110025#
name: nucleoside-diphosphate kinase (ATP:CDP), mitochondrial
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000254

http://identifiers.org/biomodels.db/MODEL1310110025#_32d2a6fd_0f25_498c_ac70_22fad6fdc598
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
name: GMPS
is: P49915
constant: false
is encoded by: hsa:8833

metaM alpa hs c
is: CHEBI:52288
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: lysophosphatidic acid
boundary condition: false
notes: FORMULA: C3H6O5PFULLRCO2 CHARGE: -2 INCHI: InChI=1S/C21H41O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26)
type: Species
initial concentration: 1.0
constant: false

metaM 7dhchsterol r
is: HMDB00032
type: Species
boundary condition: false
name: cholesta-5,7-dien-3beta-ol
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
is: CHEBI:17759
has only substance units: false

metaR ACALDtm
reactant: MODEL1310110025#
fast: false
type: Reaction
name: acetaldehyde mitochondrial diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:9028626 NOTES:NCD
is: SBO:0000185
product: MODEL1310110025#
reversible: true
kinetic law: MODEL1310110025#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110025#_1393fd10_77be_415f_b7cf_e7b2fec908e9
is encoded by: hsa:276
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is: Q6NSB3
boundary condition: true
name: AMY1A

metaR GLCAASE4ly
is version of: http://identifiers.org/ec-code/3.2.1.31
is described by: ECO:0000000
name: beta-glucuronidase, lysosomal
reversible: false
reactant: MODEL1310110025#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
modifier: MODEL1310110025#
fast: false
type: Reaction
kinetic law: MODEL1310110025#
product: MODEL1310110025#

metaR DGULND
is: SBO:0000176
product: MODEL1310110025#
type: Reaction
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
name: dehydro-L-gulonate decarboxylase
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110025#_0ecba91e_feab_4f29_a133_b31109c43709
is: SBO:0000252
name: AGPAT2
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:10555
is: O15120
type: Species

http://identifiers.org/biomodels.db/MODEL1310110025#_902b2119_4c13_4e8a_8f6c_4fcb98599750
is: P19961
initial concentration: NaN
is encoded by: hsa:280
is: SBO:0000252
constant: false
type: Species
name: AMY2B
boundary condition: true
initial amount: NaN
has only substance units: false

metaR COAtm
product: MODEL1310110025#
fast: false
is: SBO:0000185
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
modifier: MODEL1310110025#
type: Reaction
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
name: CoA transporter

metaR MALSO4tm
reversible: true
name: Malate:sulfate antiport, mitochondrial
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is described by: ECO:0000269
kinetic law: MODEL1310110025#
product: MODEL1310110025#
type: Reaction
modifier: MODEL1310110025#
fast: false
reactant: MODEL1310110025#
is: SBO:0000185

metaR r0733
modifier: MODEL1310110025#
product: MODEL1310110025#
is described by: ECO:0000000
fast: false
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
type: Reaction
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/1.5.1.12
reversible: false

metaR C226CRNt
name: C226 transport into the mitochondria
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
product: MODEL1310110025#
reversible: false
is: SBO:0000185
fast: false
reactant: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_50de4c50_bc7e_4bd3_8e97_469e8578ad13
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: P11908
type: Species
name: PRPS2
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:5634

http://identifiers.org/biomodels.db/MODEL1310110025#_412e296b_deab_43a2_a0ab_96ca84ff5867
has only substance units: false
name: SLC2A1
is encoded by: hsa:6513
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
is: P11166
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110025#_c636d96c_eb9a_49f9_ab61_70b2a8a4d6ba
has only substance units: false
name: RRM1:RRM2
type: Species
is encoded by: hsa:6241
has part: P23921
is encoded by: hsa:6240
initial amount: NaN
initial concentration: NaN
constant: false
has part: P31350
boundary condition: true
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110025#_81c4c9be_c402_4afa_b693_ce5b7bc23e80
is: Q02318
is: SBO:0000252
name: CYP27A1
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:1593
boundary condition: true
initial concentration: NaN
constant: false

metaM val L c
constant: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
has only substance units: false
is: SBO:0000247
is: CHEBI:16414
is: HMDB00883
initial concentration: 1.0
boundary condition: false
name: L-valine
type: Species
initial amount: NaN

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_db6dc0a2_7ba4_4bfd_b12a_d3acdff8088e
is: SBO:0000297
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:9091
is encoded by: hsa:5277
is encoded by: hsa:5279
boundary condition: true
has part: P57054
type: Species
has part: B2RAU6
constant: false
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
is encoded by: hsa:51227
has only substance units: false

metaM tmndnccoa c
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
name: timnodonyl coenzyme A
type: Species
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
initial amount: NaN
is: SBO:0000247
is: HMDB06514

metaM gthrd m
initial amount: NaN
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
constant: false
type: Species
is: SBO:0000247
is: HMDB00125
has only substance units: false
is: CHEBI:57925
name: glutathionate(1-)
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110025#_c5436a13_a51f_4a77_b6be_beadb96f1781
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:29920
is: Q96C36
name: PYCR2
boundary condition: true

metaM so4 l
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16189
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
constant: false
has only substance units: false
initial amount: NaN
name: sulfate
type: Species
is: HMDB01448
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110025#_d4fb0849_510c_4ee7_83c5_d4a4e2fa445a
has only substance units: false
name: NDUFB5
type: Species
is: SBO:0000252
is: O43674
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4711

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

metaM odecoa m
initial concentration: 1.0
boundary condition: false
name: Octadecenoyl-CoA (n-C18:1CoA)
constant: false
is: HMDB01322
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:57387
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510

metaR r2030
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110025#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
modifier: MODEL1310110025#
reversible: false
kinetic law: MODEL1310110025#
product: MODEL1310110025#
type: Reaction

metaR GLYt7 311 r
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
name: glycine reversible transport via sodium and chloride symport (3:1:1)
fast: false
type: Reaction
reactant: MODEL1310110025#
reversible: true
is described by: ECO:0000006
is: SBO:0000185
product: MODEL1310110025#

metaR r1551
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110025#
fast: false
reactant: MODEL1310110025#
is described by: ECO:0000000
kinetic law: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_854e95b9_525e_4fdf_a785_0082a62eacb8
name: CHAT
is: Q6LEN6
is encoded by: hsa:1103
is: SBO:0000252
boundary condition: true
constant: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR r0504
modifier: MODEL1310110025#
fast: false
is version of: http://identifiers.org/ec-code/2.3.3.10
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
type: Reaction
reactant: MODEL1310110025#
product: MODEL1310110025#
is: SBO:0000176
reversible: true
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
kinetic law: MODEL1310110025#
is described by: ECO:0000000

metaR ESTRADIOLt
product: MODEL1310110025#
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: estradiol transport
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110025#
is described by: ECO:0000000
type: Reaction

metaM srtn e
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
is: HMDB00259
name: serotonin(1+)
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
is: CHEBI:350546

metaR PNTK
is described by: ECO:0000269
reactant: MODEL1310110025#
is: SBO:0000176
product: MODEL1310110025#
modifier: MODEL1310110025#
notes: GENE_ASSOCIATION: (79646.1) or (80025.2) or (53354.1) or (53354.3) or (80025.1) or (53354.2) or (80025.3) or (80025.4) or (55229.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110025#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.33
reversible: false
fast: false
name: pantothenate kinase

http://identifiers.org/biomodels.db/MODEL1310110025#_00d468ed_8d2c_420a_aa18_cae6dfab9712
type: Species
is: Q709F0
initial concentration: NaN
name: ACAD11
initial amount: NaN
constant: false
is encoded by: hsa:84129
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR EX hista LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Histamine exchange
type: Reaction

metaM citr L c
is: CHEBI:16349
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
boundary condition: false
name: L-citrulline
has only substance units: false
initial amount: NaN
type: Species
is: HMDB00904

metaM adn c
type: Species
initial concentration: 1.0
is: C00212
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:16335
initial amount: NaN
boundary condition: false
name: Adenosine
is: HMDB00050

metaR THYMDtm
fast: false
type: Reaction
name: thymd transport
reversible: true
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:TDV
kinetic law: MODEL1310110025#
is described by: ECO:0000269
product: MODEL1310110025#
modifier: MODEL1310110025#
is: SBO:0000185
reactant: MODEL1310110025#

http://identifiers.org/biomodels.db/MODEL1310110025#_350d64fb_14c5_4d0f_aee9_05b3c9432d85
is: SBO:0000252
constant: false
name: ALDOC
is encoded by: hsa:230
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: P09972
has only substance units: false

metaM so4 e
is: HMDB01448
initial amount: NaN
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:16189
has only substance units: false
initial concentration: 1.0
constant: false
name: sulfate

metaM coa r
name: Coenzyme A
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57287
constant: false
is: C00010
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: HMDB01423

http://identifiers.org/biomodels.db/MODEL1310110025#_ff44dd8c_ec18_438c_9829_66442d591614
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5139
has only substance units: false
name: PDE3A
boundary condition: true
constant: false
type: Species
is: SBO:0000252
is: Q14432

metaM tyr L e
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
is: CHEBI:17895
constant: false
initial amount: NaN
name: L-tyrosine
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00158
boundary condition: false
type: Species

metaR MAL Lte
is: SBO:0000185
reactant: MODEL1310110025#
fast: false
reversible: true
name: Transport of L-malate
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110025#
type: Reaction
product: MODEL1310110025#
is described by: ECO:0000134

metaM pi m
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
boundary condition: false
is: C00009
name: hydrogenphosphate
initial amount: NaN
is: SBO:0000247
is: CHEBI:43474
is: HMDB00973
has only substance units: false
type: Species
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110025#_906b1c0f_4fe6_4d5e_a343_d1b4e1e36700
constant: false
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:51292
is: SBO:0000252
name: GMPR2
has only substance units: false
is: Q86T14
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110025#_93bb6f03_1af6_4bae_92e5_743d979dae36
name: SDHC
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6391
is: SBO:0000252
type: Species
is: Q99643

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

metaR ADEt
product: MODEL1310110025#
reversible: true
name: adenine reversible transport, cytosol
fast: false
modifier: MODEL1310110025#
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
reactant: MODEL1310110025#

metaR DATPtn
is described by: ECO:0000000
reactant: MODEL1310110025#
kinetic law: MODEL1310110025#
reversible: true
name: dATP diffusion in nucleus
product: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
type: Reaction
is: SBO:0000185

metaR r2532
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
type: Reaction
reactant: MODEL1310110025#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110025#
fast: false
kinetic law: MODEL1310110025#
is: SBO:0000185

metaR NDP7ex
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12600208 NOTES:
modifier: MODEL1310110025#
reversible: false
product: MODEL1310110025#
name: nucleoside-diphosphatase (UDP), extracellular
reactant: MODEL1310110025#
is version of: http://identifiers.org/ec-code/3.6.1.6

http://identifiers.org/biomodels.db/MODEL1310110025#_fc59710e_9a7b_4b53_bf90_ee27cca462c5
type: Species
is encoded by: hsa:10768
has only substance units: false
constant: false
boundary condition: true
name: AHCYL1
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaM ocdca e
constant: false
has only substance units: false
boundary condition: false
is: HMDB00827
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
type: Species
name: octadecanoate (n-C18:0)
is: C01530
is: SBO:0000247
is: CHEBI:25629

metaM bhb m
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:10983
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
initial amount: NaN
name: (R)-3-hydroxybutyrate
is: HMDB00011
type: Species
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110025#_f8c2c554_07e7_4094_9c4c_e608c5c5f42e
name: ACADL
constant: false
type: Species
initial amount: NaN
is: P28330
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:33

http://identifiers.org/biomodels.db/MODEL1310110025#_45dc266f_9052_493a_9d27_fbb9784fcb27
constant: false
type: Species
name: SLC25A21
is: G3V4L5
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:89874

metaM 5adtststerone r
name: 17beta-hydroxy-5alpha-androstan-3-one
has only substance units: false
boundary condition: false
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
initial amount: NaN
constant: false
is: HMDB02961
is: CHEBI:16330
initial concentration: 1.0
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110025#_d56bbac8_e2cd_47cd_b416_680c1dd8df8d
name: COX6A2
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:1339
is: Q02221
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_7a20e29c_f132_40aa_bd46_cc3bcf8693a5
constant: false
name: ACSS1
has only substance units: false
initial amount: NaN
boundary condition: true
is: Q9NUB1
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:84532

metaM pi n
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
has only substance units: false
name: hydrogenphosphate
type: Species
constant: false
is: HMDB00973
is: CHEBI:43474

metaR COAtr
product: MODEL1310110025#
kinetic law: MODEL1310110025#
type: Reaction
name: COA transporter, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reversible: true
reactant: MODEL1310110025#
is described by: ECO:0000000
fast: false
is: SBO:0000185

metaM gln L m
name: L-glutamine
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: HMDB00641
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: SBO:0000247
is: CHEBI:18050

metaM citr L e
name: citr_L[e]
is: SBO:0000247
is: CHEBI:16349
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00904
boundary condition: false
type: Species
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110025#_b8a6cc0d_79e7_425c_8718_5f243c3f6872
is: SBO:0000252
is encoded by: hsa:AV717590
type: Species
boundary condition: true
initial amount: NaN
constant: false
name: _AV717590_1_c
initial concentration: NaN
has only substance units: false

metaM HC00229 e
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
boundary condition: false
type: Species
is: CHEBI:28189
name: Isomaltose

metaM lpam m
is: SBO:0000247
is: HMDB00962
initial concentration: 1.0
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
boundary condition: false
initial amount: NaN
constant: false
type: Species
is: CHEBI:17460
has only substance units: false
name: lipoamide

http://identifiers.org/biomodels.db/MODEL1310110025#_29edfcf0_f3c5_4d22_9835_465b815250ba
is encoded by: hsa:5315
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: P14618
name: PKM2
type: Species
boundary condition: true

metaR URIt
fast: false
kinetic law: MODEL1310110025#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
reversible: true
product: MODEL1310110025#
name: uridine facilated transport in cytosol
reactant: MODEL1310110025#
type: Reaction
modifier: MODEL1310110025#
is described by: ECO:0000269
is: SBO:0000185

metaR r1156
reactant: MODEL1310110025#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
product: MODEL1310110025#
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
is: SBO:0000176
kinetic law: MODEL1310110025#
reversible: true
type: Reaction
is described by: ECO:0000000

metaR r0881
name: Active transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12107270,PMID:12739169,PMID:12829793,PMID:17245649,PMID:18375207,PMID:8476015,PMID:8557697,PMID:9786900 NOTES:
product: MODEL1310110025#
fast: false
kinetic law: MODEL1310110025#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110025#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110025#_f26b6706_394f_4fc1_a720_81430a5acd3b
is: SBO:0000252
constant: false
is encoded by: hsa:H45672
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: _H45672_1_m
type: Species

metaR r2535
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110025#
reactant: MODEL1310110025#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110025#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1

metaM lnlc c
constant: false
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
has only substance units: false
boundary condition: false
is: CHEBI:30245
is: SBO:0000247
initial concentration: 1.0
type: Species
name: linoleate
initial amount: NaN
is: HMDB00673

metaM lnlc r
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB00673
constant: false
name: linoleate
initial concentration: 1.0
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC00796 EHMN_ABBREVIATION: C01595
is: CHEBI:30245
has only substance units: false