http://identifiers.org/biomodels.db/MODEL1310110024#_dec57e99_189d_40ef_acd5_97267a466f71
initial amount: NaN
boundary condition: true
is encoded by: hsa:AI348006
initial concentration: NaN
constant: false
has only substance units: false
name: _AI348006_1_c
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_607d646e_a884_49b4_a679_8f8b423b4b98
type: Species
has only substance units: false
initial concentration: NaN
name: UROC1
boundary condition: true
is: Q68CJ7
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:131669
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_cba3a0dc_f56b_4eb8_a072_a296b6b78005
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:10948
is: SBO:0000252
is: B4DUY1
name: STARD3
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_94cdff94_20ce_41f0_b5ea_705b63d582c8
boundary condition: true
constant: false
is: Q6IBK2
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
name: KHK
is: SBO:0000252
is encoded by: hsa:3795

metaM cit c
is: C00158
initial amount: NaN
is: CHEBI:16947
has only substance units: false
name: Citrate
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
constant: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: HMDB00094

metaM apoC Lys btn m
is: C05552
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/7886
is: HMDB03134
notes: FORMULA: C16H27N4O3SX CHARGE: 0
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_5548b373_816f_4aea_8afc_e84ed516a5af
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:223
boundary condition: true
name: ALDH9A1
initial amount: NaN
is: P49189

metaM ksi deg14 l
type: Species
has only substance units: false
is: CHEBI:12936
is: SBO:0000247
name: keratan sulfate I, degradation product 14
initial amount: NaN
boundary condition: false
is: HMDB00143
initial concentration: 1.0
notes: FORMULA: C166H267N11O145S8 CHARGE: -8
constant: false

metaM fe2 c
initial amount: NaN
is: C00023
boundary condition: false
is: HMDB00692
initial concentration: 1.0
constant: false
type: Species
name: Fe2+
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
is: SBO:0000247
has only substance units: false
is: CHEBI:29033

metaR EX 34dhphe LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3,4-Dihydroxy-L-phenylalanine exchange
type: Reaction

metaM cys L e
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: L-cysteine
constant: false
is: HMDB00574
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
is: CHEBI:17561

metaR RE2426C
kinetic law: MODEL1310110024#
type: Reaction
name: RE2426
reversible: true
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12044950 NOTES:
reactant: MODEL1310110024#
is: SBO:0000176
is described by: ECO:0000000
fast: false

metaR S23T4g
name: beta-galactoside alpha-2,3-sialyltransferase
fast: false
reversible: false
product: MODEL1310110024#
reactant: MODEL1310110024#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.4.99.4
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
is described by: ECO:0000000
modifier: MODEL1310110024#

metaM atp c
is: CHEBI:30616
is: C00002
type: Species
is: HMDB00538
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: ATP(4-)
is: SBO:0000247
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_7b41a798_a61c_44e0_84b3_3df54d140c3c
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:10455
name: ECI2
initial concentration: NaN
constant: false
is: O75521

metaM hexdiac c
type: Species
has only substance units: false
name: hexadecanediocacid
initial amount: NaN
is: C08260
notes: FORMULA: C16H28O4 CHARGE: -2
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB00672

metaR GTHP
modifier: MODEL1310110024#
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.11.1.15
is version of: http://identifiers.org/ec-code/1.11.1.9
name: glutathione peroxidase
is version of: http://identifiers.org/ec-code/1.11.1.12
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
is described by: ECO:0000134
type: Reaction
reversible: true
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110024#_83dc5cbf_4801_4dd7_ba77_db672cfe764b
is encoded by: hsa:2686
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
is: A0PJJ9
type: Species
initial amount: NaN
name: GGT7
boundary condition: true

metaM lnlncg l
is: SBO:0000247
type: Species
is: HMDB03073
name: gamma-linolenate
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:32391
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_5ad59020_2e7a_42e8_a4bb_9f0dabce8515
initial concentration: NaN
is: P08397
constant: false
type: Species
name: HMBS
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3145

metaR FAOXC221C201x
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:1-->C20:1)x
type: Reaction

metaM pydx c
boundary condition: false
is: HMDB01545
notes: FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: Pyridoxal
initial concentration: 1.0
is: C00250
constant: false
is: CHEBI:17310
type: Species

metaR EX pheacgln LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-N-Phenylacetyl-L-glutamine exchange
type: Reaction

metaM slfcys e
is: C05824
is: HMDB00731
name: S-Sulfo-L-cysteine
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C3H8NO5S2 CHARGE: -1
is: SBO:0000247
has only substance units: false
boundary condition: false

metaR HMGLx
notes: GENE_ASSOCIATION: (3155.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:TV NJ added peroxisomal version - see Olivier Biochimica et Biophysica Act 1529 (2000) 89-102
name: hydroxymethylglutaryl-CoA lyase
is version of: http://identifiers.org/ec-code/4.1.3.4
modifier: MODEL1310110024#
is: SBO:0000176
reactant: MODEL1310110024#
product: MODEL1310110024#
reversible: false
is described by: ECO:0000134
type: Reaction
fast: false
kinetic law: MODEL1310110024#

metaR GTHS
product: MODEL1310110024#
kinetic law: MODEL1310110024#
name: glutathione synthetase
is version of: http://identifiers.org/ec-code/6.3.2.3
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (2937.1) SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110024#
fast: false
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110024#

metaR DOLP Uter
product: MODEL1310110024#
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110024#
name: dolichol phosphate flippase (uterus)
reactant: MODEL1310110024#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:

metaR r0789
type: Reaction
fast: false
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000000
product: MODEL1310110024#
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.14.13.15
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:

metaM xol25oh r
boundary condition: false
is: HMDB06247
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01146
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:42977
constant: false
type: Species
name: 25-hydroxycholesterol

http://identifiers.org/biomodels.db/MODEL1310110024#_3cc8ebea_5a43_460c_a832_138f1e7f97fe
is: P43034
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:5048
name: PAFAH1B1
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_8e37e544_d919_4d5a_800c_388bed553f29
is: SBO:0000252
is: B4DPV0
initial amount: NaN
is encoded by: hsa:5236
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
name: PGM1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_6662426f_bfd8_470d_9b81_94d88660d910
boundary condition: true
name: RRM1
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
is: P23921
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6240

metaM cys L c
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17561
name: L-cysteine
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB00574
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099

metaM slfcys c
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C3H8NO5S2 CHARGE: -1
constant: false
is: HMDB00731
name: S-Sulfo-L-cysteine
has only substance units: false
is: SBO:0000247
is: C05824

http://identifiers.org/biomodels.db/MODEL1310110024#_460feb34_4f2b_4a4a_a8b9_76f04eeb1b59
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:AGPAT7
name: _AGPAT7_1_c

metaM eicostet c
is: SBO:0000247
is: HMDB02177
has only substance units: false
is: CHEBI:36033
type: Species
name: eicosatetranoic acid
notes: FORMULA: C20H31O2 CHARGE: -1
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110024#_0f97c4eb_fa38_42bf_b168_60e8e5ce078e
is: P50225
is: SBO:0000252
is encoded by: hsa:6817
constant: false
type: Species
boundary condition: true
initial concentration: NaN
name: SULT1A1
has only substance units: false
initial amount: NaN

metaM atp e
is: C00002
type: Species
is: HMDB00538
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57299
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
name: ATP(4-)

metaM 7dhchsterol r
is: HMDB00032
name: cholesta-5,7-dien-3beta-ol
initial amount: NaN
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:17759
boundary condition: false

metaR r0788
is: SBO:0000176
reversible: true
reactant: MODEL1310110024#
type: Reaction
product: MODEL1310110024#
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.14.13.15
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110024#

metaM mi13p c
constant: false
has only substance units: false
type: Species
is: HMDB06234
is: SBO:0000247
initial amount: NaN
is: CHEBI:18225
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)5(17-19(11,12)13)4(10)6(3(1)9)18-20(14,15)16/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3+,4+,5+,6-
initial concentration: 1.0
name: 1D-myo-Inositol 1,3-bisphosphate
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110024#_82d56e04_a5bf_498c_a780_2d10895641ea
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:957
has only substance units: false
type: Species
name: ENTPD5
constant: false
is: O75356
boundary condition: true

metaR LEUTA
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
is described by: ECO:0000269
reactant: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
reversible: true
is: SBO:0000176
name: leucine transaminase
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.42
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#

metaR 41R2A1H12BOOX
name: 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing)
type: Reaction
reversible: false
fast: false
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
is described by: ECO:0000269
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is: SBO:0000176
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.4.3.4

metaM 5dpmev x
has only substance units: false
is: HMDB01090
initial amount: NaN
is: CHEBI:15899
type: Species
name: (R)-5-Diphosphomevalonate
initial concentration: 1.0
constant: false
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00685 EHMN_ABBREVIATION: C01143
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110024#_e62bef58_d88c_40ec_9071_851a068ad218
is: Q15181
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
name: PPA1
type: Species
is encoded by: hsa:5464
initial concentration: NaN
is: SBO:0000252

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

metaM anth c
is: CHEBI:16567
is: HMDB01123
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
initial amount: NaN
has only substance units: false
name: anthranilate
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110024#_2b674c42_b182_4651_8857_41b67c63060b
is encoded by: hsa:10195
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: ALG3
is: Q92685

http://identifiers.org/biomodels.db/MODEL1310110024#_476e57a5_eb1d_4b06_a123_854529b5e44a
is encoded by: hsa:AI990637
constant: false
type: Species
is: SBO:0000252
name: _AI990637_1_x
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110024#_15519ee2_3fba_4a1a_a50c_42a783ee4d5d
type: Species
initial amount: NaN
is encoded by: hsa:1351
has only substance units: false
boundary condition: true
name: COX8A
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q53XN1

http://identifiers.org/biomodels.db/MODEL1310110024#_86ff55bb_df8d_4557_a166_38af1248f607
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:51022
initial amount: NaN
type: Species
is: Q9NS18
name: GLRX2

metaM eicostet e
boundary condition: false
is: CHEBI:36033
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C20H31O2 CHARGE: -1
is: HMDB02177
initial amount: NaN
has only substance units: false
constant: false
name: eicosatetranoic acid

metaR RETH
type: Reaction
modifier: MODEL1310110024#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8228.1) SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:1503811,PMID:15955102 NOTES:IT
kinetic law: MODEL1310110024#
product: MODEL1310110024#
fast: false
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.1.1.3
name: retinyl ester hydrolase
reactant: MODEL1310110024#

metaM ptdca e
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)
is: http://identifiers.org/pubchem.compound/22169126
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB00826
name: pentadecanoate
type: Species

metaR 5MTHFt
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
type: Reaction
reversible: true
product: MODEL1310110024#
is described by: ECO:0000269
fast: false
is: SBO:0000185
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#

metaR RTOTALt
name: RTOTAL transport
kinetic law: MODEL1310110024#
type: Reaction
reactant: MODEL1310110024#
fast: false
is: SBO:0000185
product: MODEL1310110024#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000

metaM gal c
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:0
constant: false
name: D-Galactose
notes: FORMULA: C6H12O6 CHARGE: 0
is: HMDB00143
is: C00124
boundary condition: false
has only substance units: false

metaM ksi deg2 l
is: HMDB06529
is: CHEBI:50570
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C241H384N17O210S12 CHARGE: -13
is: SBO:0000247
boundary condition: false
constant: false
name: keratan sulfate I, degradation product 2

http://identifiers.org/biomodels.db/MODEL1310110024#_db829f29_3dc9_4d0a_b8a2_934fd0f5e390
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
name: _AA977580_1_c
type: Species
is encoded by: hsa:AA977580
is: SBO:0000252

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

metaM pail34p hs c
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
boundary condition: false
initial concentration: 1.0
is: CHEBI:57658
type: Species
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)
is: SBO:0000247

metaM trdox c
type: Species
initial amount: NaN
is: C00343
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
is: CHEBI:18191
initial concentration: 1.0
name: Oxidized thioredoxin
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false

metaM dhf c
is: CHEBI:57451
constant: false
name: 7,8-Dihydrofolate
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB01056
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
has only substance units: false
is: C00415
is: SBO:0000247

metaR FAOXC200180m
modifier: MODEL1310110024#
fast: false
is: SBO:0000176
reactant: MODEL1310110024#
type: Reaction
reversible: false
kinetic law: MODEL1310110024#
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation of long chain fatty acid

http://identifiers.org/biomodels.db/MODEL1310110024#_69c58862_db7d_4c6e_9211_d9ffa4daf59a
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2
is encoded by: hsa:517
has only substance units: false
has part: Q06055
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
boundary condition: true
is: SBO:0000297

metaR UPPDC1
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
reactant: MODEL1310110024#
product: MODEL1310110024#
is described by: ECO:0000269
reversible: false
name: uroporphyrinogen decarboxylase (uroporphyrinogen III)
type: Reaction
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.37
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Heme synthesis EC Number: 4.1.1.37 Confidence Level: 4 AUTHORS: PMID:3015909 NOTES:Acts on a number of porphyrinogens, r0606

metaM anth e
is: SBO:0000247
is: CHEBI:16567
has only substance units: false
is: HMDB01123
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
name: anthranilate
constant: false
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1

http://identifiers.org/biomodels.db/MODEL1310110024#_35ccaa48_3b09_4a73_9463_a60aa3a0d531
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
name: MAN2A1
type: Species
is encoded by: hsa:4124
is: Q16706
initial concentration: NaN
constant: false

metaM cit e
is: HMDB00094
is: SBO:0000247
constant: false
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: CHEBI:16947
boundary condition: false
name: citrate(3-)
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false

metaR r0672
product: MODEL1310110024#
name: Cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase Bile acid biosynthesis EC:1.1.1.181
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110024#
fast: false
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.65
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.181 Confidence Level: 0 AUTHORS: PMID:12679481 NOTES:
type: Reaction

metaR FUCASE2ly
kinetic law: MODEL1310110024#
name: alpha-fucosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.51
notes: GENE_ASSOCIATION: (2517.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:11870229,PMID:1769200,PMID:2803312,PMID:2983333 NOTES:NCD
type: Reaction
reversible: false
reactant: MODEL1310110024#
product: MODEL1310110024#
is: SBO:0000176
fast: false
modifier: MODEL1310110024#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110024#_68c7950c_ccdf_4350_b955_0b8b5c9fb12b
is: Q02318
initial amount: NaN
is: SBO:0000252
name: CYP27A1
constant: false
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1593

http://identifiers.org/biomodels.db/MODEL1310110024#_9eedd8ba_0eba_4bd5_8390_c4e90bb3063a
boundary condition: true
constant: false
is encoded by: hsa:27068
type: Species
is: SBO:0000252
has only substance units: false
name: PPA2
initial concentration: NaN
initial amount: NaN

metaM but c
initial concentration: 1.0
name: butyrate
constant: false
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
type: Species
has only substance units: false
is: HMDB00039
is: CHEBI:17968
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaR GTHO
reversible: false
is version of: http://identifiers.org/ec-code/1.8.1.7
reactant: MODEL1310110024#
fast: false
kinetic law: MODEL1310110024#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
name: glutathione oxidoreductase
product: MODEL1310110024#
is described by: ECO:0000254
modifier: MODEL1310110024#

metaM aicar e
is: HMDB01517
type: Species
initial amount: NaN
is: CHEBI:58475
is: C04677
constant: false
initial concentration: 1.0
is: SBO:0000247
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
notes: FORMULA: C9H13N4O8P CHARGE: -2
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110024#_5aefd180_f3f7_43a3_98e4_a4716c2c880b
has part: P00326
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:126
name: ADH1A:ADH1C
constant: false
is: SBO:0000297
initial concentration: NaN

metaR FAOXC2031836m
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:3 -> c18:3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
fast: false
reversible: false
is: SBO:0000176
name: Beta oxidation of fatty acid
type: Reaction
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110024#
modifier: MODEL1310110024#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110024#_f8b59804_b0ce_4cd6_8871_56cd680624b6
name: AKR1B1
initial concentration: NaN
constant: false
is encoded by: hsa:231
has only substance units: false
initial amount: NaN
is: P15121
boundary condition: true
is: SBO:0000252
type: Species

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

metaM ptdca c
constant: false
name: pentadecanoate
initial amount: NaN
is: http://identifiers.org/pubchem.compound/22169126
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)
is: HMDB00826

metaR ALAGLNexR
modifier: MODEL1310110024#
is: SBO:0000185
name: L-alanine/glutamine reversible exchange
is described by: ECO:0000304
fast: false
reversible: true
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

metaR KCC2t
fast: false
product: MODEL1310110024#
type: Reaction
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
is: SBO:0000185
reversible: true
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
name: K+-Cl- cotransporter (NH4+)
is described by: ECO:0000269

metaR r0671
kinetic law: MODEL1310110024#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.22
product: MODEL1310110024#
modifier: MODEL1310110024#
is: SBO:0000176
name: (R)-4-Phosphopantothenate:L-cysteine ligase EC:6.3.2.5
reactant: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: (2717.1) or (6173.1) SUBSYSTEM: CoA synthesis EC Number: 6.3.2.5 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:12906824,PMID:15893380 NOTES:
reversible: false
type: Reaction

metaR GGH 10FTHF7GLUe
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
reversible: false
is version of: http://identifiers.org/ec-code/3.4.19.9
product: MODEL1310110024#
type: Reaction
reactant: MODEL1310110024#
name: Gamma-glutamyl hydrolase (10FTHF7GLU), extracellular
fast: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT

metaM CE0233 c
type: Species
boundary condition: false
initial amount: NaN
name: 5beta-cholestane-3alpha,7alpha,27-triol
constant: false
is: CHEBI:17899
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1/C27H48O3/c1-17(7-6-12-25(2,3)30)20-8-9-21-24-22(11-14-27(20,21)5)26(4)13-10-19(28)15-18(26)16-23(24)29/h17-24,28-30H,6-16H2,1-5H3/t17-,18-,19+,20-,21-,22-,23+,24-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE0233
has only substance units: false
is: HMDB01993

metaM hco3 e
type: Species
initial amount: NaN
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:17544
name: Bicarbonate
constant: false
is: HMDB00595
is: C00288

metaM ksi g
initial concentration: 1.0
type: Species
is: CHEBI:17140
is: SBO:0000247
constant: false
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
has only substance units: false
name: keratan sulfate I
boundary condition: false
is: HMDB01644
initial amount: NaN

metaM gacpail hs c
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:16344
is: HMDB00128
name: glucosaminyl-acylphosphatidylinositol
initial amount: NaN
is: SBO:0000247
type: Species

metaM but e
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
name: butyrate
is: CHEBI:17968
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
has only substance units: false
boundary condition: false
is: HMDB00039
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_3db5ac09_788f_4da7_9b79_03fdc4b11670
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:5169
name: ENPP3
type: Species
initial amount: NaN
initial concentration: NaN
is: Q308M7

metaR r0783
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110024#
reversible: true
type: Reaction
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110024#
is: SBO:0000176
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:

metaR HMGLm
is: SBO:0000176
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (3155.1) or (54511.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11129331 NOTES:TV
type: Reaction
kinetic law: MODEL1310110024#
fast: false
reactant: MODEL1310110024#
reversible: false
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/4.1.3.4
is described by: ECO:0000134
name: hydroxymethylglutaryl-CoA lyase

MODEL1310110024#
species: metaM arach c
species: metaM acnacngalgbside hs c
species: metaM ksi pre26 g
species: metaM pep c
species: metaM cspg a l
species: metaM pail45p hs n
species: metaM air c
species: metaM h2o g
species: metaM CE2424 m
species: metaM h2o2 e
species: metaM HC01162 c
species: metaM hdcoa c
species: metaM Asn X Ser Thr l
species: metaM ptdcacrn c
species: metaM bilglcur e
species: metaM chol n
stoichiometry: 1.0
species: metaM hs deg9 l
species: metaM dc2coa x
species: metaM HC02207 c
species: metaM CE5789 e
species: metaM 7dhf e
species: metaM 4hbzcoa m
species: metaM dec24dicoa x
species: metaM pail345p hs c
species: metaM cs e deg2 l
species: metaM dlnlcg c
species: metaM ala B m
species: metaM prostgh2 r
species: metaM h2o c
species: metaM sgalside hs c
species: metaM ksii core4 deg4 l
has only substance units: false
species: metaM m8mpdol L r
species: metaM xan c
species: metaM ala L m
name: ACAA1:HSD17B4:ACOX1
species: metaM cmpacna n
species: metaM thf c
species: metaM abt e
species: metaM mmcoa S m
species: metaM c6crn e
species: metaM cyan m
species: metaM gtp n
species: metaM fuc1p L c
species: metaM 4izp c
species: metaM frdp x
species: metaM m7mpdol L r
species: metaM HC01459 x
species: metaM asp D e
species: metaM c10dc e
species: metaM man l
species: metaM 2octpencoa m
species: metaM pa hs m
species: metaM pmtcoa x
species: metaM tyr L e
species: metaM accoa c
species: metaM 4nphsf e
species: metaM hyptaur c
species: metaM ocdcea c
species: metaM gm3 hs g
species: metaM acetone m
species: metaM datp m
species: metaM hs deg1 l
species: metaM cs e deg7 l
species: metaM pro D e
name: ATP1A1:ATP1B1
species: metaM gln L m
species: metaM damp c
species: metaM ksi pre24 g
species: metaM mpdol U c
species: metaM g2m8mpdol U r
species: metaM Rtotal3 e
species: metaM ascb L c
species: metaM CE2422 m
species: metaM prgstrn c
species: metaM hestratriol r
species: metaM glyb c
species: metaM mev R c
species: metaM docosahexcoa m

http://identifiers.org/biomodels.db/MODEL1310110024#_cb2444fd_344a_496c_a0a3_357b1eabbd3b
name: FH
constant: false
initial amount: NaN
initial concentration: NaN
is: P07954
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:2271
has only substance units: false

metaR PEAMNO
is: SBO:0000176
kinetic law: MODEL1310110024#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.22
modifier: MODEL1310110024#
name: Phenethylamine oxidase
is version of: http://identifiers.org/ec-code/1.4.3.4
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.4.3.21
reversible: false
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (314.1) or (4128.1) or (26.1) or (4129.1) or (314.2) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:10389141,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:JLR- Kegg reaction R02613
reactant: MODEL1310110024#

metaR 3DPHBH2
fast: false
type: Reaction
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11051212 NOTES:Used to make Ubiquinone-10 enzyme has not been identified yet. IT
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
reversible: false
is: SBO:0000176
name: Hydroxylation of 3-Decaprenyl-4-hydroxybenzoate (NADPH)
is described by: ECO:0000000

metaM ksi pre28 g
is: HMDB00175
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C213H341N15O176S8X CHARGE: -9
initial concentration: 1.0
is: CHEBI:58053
is: C00130
is: SBO:0000247
has only substance units: false
type: Species
name: keratan sulfate I biosynthesis, precursor 28

metaM 3ddecdicoa x
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
initial concentration: 1.0
name: 3,6-dodecadienoylcoa
is: SBO:0000247
is: HMDB03952
boundary condition: false
constant: false
is: C05280
initial amount: NaN
type: Species
has only substance units: false

metaM HC02203 c
type: Species
name: prostaglandin-a2
initial amount: NaN
is: CHEBI:27820
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
is: SBO:0000247
boundary condition: false

metaR PPCOAOm
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (80724.1) or (27034.1) or (36.1) or (35.1) or (84129.1) or (34.1) or (28976.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:12359132,PMID:12359260,PMID:15560374,PMID:2565344,PMID:3035565,PMID:7698750,PMID:8276399 NOTES:NCD
type: Reaction
fast: false
product: MODEL1310110024#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
name: Propanoyl-CoA:FAD 2,3-oxidoreductase, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110024#_0afacf77_80d8_43cb_977f_4270cd08b07c
type: Species
constant: false
is: SBO:0000252
name: ACAA1
is: Q96CA6
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:30
initial concentration: NaN

metaR PAIL45P HStn
reactant: MODEL1310110024#
is: SBO:0000185
fast: false
type: Reaction
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
reversible: true
kinetic law: MODEL1310110024#
product: MODEL1310110024#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110024#_d8e20951_f9a1_44df_9427_147efa8017af
is: Q9UI32
initial amount: NaN
initial concentration: NaN
type: Species
name: GLS2
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:27165
constant: false

metaM gtp n
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:37565
is: HMDB01273
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
name: GTP(4-)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110024#_9b576710_6f0c_4e5b_85f1_b06f28f3822d
boundary condition: true
has only substance units: false
constant: false
is: Q7GXY8
name: COX1
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4512
is: SBO:0000252
type: Species

metaM ksi e
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB00211
is: CHEBI:17268
name: keratan sulfate I
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110024#_fe944bad_6e27_484d_9816_291abbe903c5
is: O00400
is encoded by: hsa:9197
has only substance units: false
is: SBO:0000252
name: SLC33A1
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
type: Species

metaM fe2 m
has only substance units: false
is: C00023
is: CHEBI:29033
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB00692
type: Species
initial amount: NaN
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
name: Fe2+
boundary condition: false

metaM leuktrF4 c
boundary condition: false
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
is: SBO:0000247
is: CHEBI:27491
constant: false
initial amount: NaN
is: HMDB06465
type: Species
has only substance units: false
initial concentration: 1.0
name: leukotriene F4

metaM ksii core2 pre3 g
is: CHEBI:58053
has only substance units: false
type: Species
is: SBO:0000247
constant: false
boundary condition: false
is: C00130
notes: FORMULA: C47H76N4O33X CHARGE: -1
initial concentration: 1.0
is: HMDB00175
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 3

http://identifiers.org/biomodels.db/MODEL1310110024#_6c115012_8b74_4f75_9e27_422886b57994
has only substance units: false
name: _AI971023_1_c
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:AI971023
boundary condition: true
type: Species
is: SBO:0000252

metaR r0781
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110024#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
name: Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) Biosynthesis of steroids EC:1.14.13.70
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.13.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
kinetic law: MODEL1310110024#

metaR DGTPtn
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110024#
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
name: dGTP diffusion in nucleus

metaM adpcoa c
has only substance units: false
is: C14143
is: HMDB04047
is: SBO:0000247
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
initial concentration: 1.0
boundary condition: false
type: Species
name: adipoylcoa
initial amount: NaN
constant: false

metaM cs a l
is: SBO:0000247
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
is: CHEBI:36005
constant: false
initial amount: NaN
name: chondroitin sulfate A (GalNAc4S-GlcA), free chain
has only substance units: false
is: HMDB02183
boundary condition: false
type: Species
initial concentration: 1.0

metaR ALDD2y
is: SBO:0000176
product: MODEL1310110024#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (223.1) or (221.1) or (218.1) or (8854.1) or (8854.3) or (222.1) or (8854.2) or (224.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.4 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:See also ALDH1 (1.2.1.3); r0177
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110024#
name: aldehyde dehydrogenase (acetaldehyde, NADP)
reversible: false
modifier: MODEL1310110024#
type: Reaction
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.2.1.36
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110024#_88396356_be0d_499a_be6c_25c74ee5e584
initial amount: NaN
name: DGKZ
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:8525
is: B7Z6M3
boundary condition: true
constant: false

metaM HC02214 c
name: prostaglandin-f1alpha
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
is: CHEBI:28852
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR BPNT
is described by: ECO:0000269
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.1.3.7
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
fast: false
reversible: false
name: 3',5'-bisphosphate nucleotidase
product: MODEL1310110024#
kinetic law: MODEL1310110024#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_cb142d3f_5aea_4624_8eb3_b10ca7e9b2bc
is: Q9HCR9
is encoded by: hsa:50940
type: Species
name: PDE11A
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN

metaM gtp m
constant: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB01273
initial concentration: 1.0
is: C00044
name: GTP
boundary condition: false
is: CHEBI:37565
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_2793c18f_710c_4258_b3c9_2db44be825a1
is: Q96IJ6
is encoded by: hsa:29926
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: GMPPA
has only substance units: false
type: Species
boundary condition: true
constant: false

metaR RE1804M
modifier: MODEL1310110024#
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
reactant: MODEL1310110024#
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
name: RE1804
is: SBO:0000176
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.14.13.15

metaR FBA
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/4.1.2.13
modifier: MODEL1310110024#
fast: false
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (230.1) or (229.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:12626877,PMID:6765112 NOTES:6765112 - fluorescence of presence in human brain
is: SBO:0000176
name: fructose-bisphosphate aldolase
reactant: MODEL1310110024#
reversible: true
kinetic law: MODEL1310110024#

metaM HC02203 e
initial amount: NaN
type: Species
constant: false
is: CHEBI:27820
name: prostaglandin-a2
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
has only substance units: false
boundary condition: false

metaM hxcoa x
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00705
type: Species
constant: false
name: Hexanoyl-CoA (n-C6:0CoA)
initial amount: NaN

metaR ALDD2x
kinetic law: MODEL1310110024#
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.3
name: aldehyde dehydrogenase (acetaldehyde, NAD)
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
notes: GENE_ASSOCIATION: (218.1) or (501.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (223.1) or (220.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:Only acetaldehyde considered for now. See also 1.2.1.4. Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. Formerly EC 1.1.1.70; r0176
modifier: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.36

metaR RE3270C
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:IT - fixed proton
product: MODEL1310110024#
type: Reaction
name: RE3270
kinetic law: MODEL1310110024#
is: SBO:0000176
fast: false
reactant: MODEL1310110024#
is described by: ECO:0000000
reversible: true

metaM gal e
notes: FORMULA: C6H12O6 CHARGE: 0
is: CHEBI:0
boundary condition: false
constant: false
is: SBO:0000247
name: D-Galactose
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB00143
is: C00124
type: Species

metaR r0780
is described by: ECO:0000000
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
kinetic law: MODEL1310110024#
type: Reaction
product: MODEL1310110024#
reversible: true
reactant: MODEL1310110024#
fast: false

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

metaM ksi deg33 l
notes: FORMULA: C76H125N5O62S2 CHARGE: -2
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB00143
is: SBO:0000247
type: Species
name: keratan sulfate I, degradation product 33
is: CHEBI:12936
initial amount: NaN
boundary condition: false

metaR r0787
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
fast: false
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
product: MODEL1310110024#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
is version of: http://identifiers.org/ec-code/1.1.1.1
type: Reaction
reactant: MODEL1310110024#

metaM fmn c
name: FMN
is: HMDB01520
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
type: Species
has only substance units: false
is: CHEBI:58210
is: C00061
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110024#_34f2fe15_f786_4a49_a4e0_967f2536ca00
is encoded by: hsa:4726
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
name: NDUFS6
is: Q6IBC4
type: Species
boundary condition: true

metaM gal l
is: CHEBI:12936
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: D-galactose
constant: false
initial amount: NaN
is: HMDB00143
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124

metaM dlnlcg e
is: CHEBI:53486
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
type: Species
constant: false
boundary condition: false
is: HMDB02925
initial amount: NaN
name: dihomo-gamma-linolenic acid (n-6)
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110024#_b3b1a1cd_21b1_452f_ad70_3f11b5a82334
type: Species
name: ACSL3
initial concentration: NaN
constant: false
is encoded by: hsa:2181
is: SBO:0000252
initial amount: NaN
is: O95573
has only substance units: false
boundary condition: true

metaM HC02179 e
initial concentration: 1.0
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
name: 20-hydroxy-arachidonate
is: CHEBI:34306
type: Species
boundary condition: false

metaR r1459
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
reversible: true
fast: false
kinetic law: MODEL1310110024#
name: Transport reaction
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110024#_076f170b_865d_46b1_a9b7_2476d018f725
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:8611
is: G3XA95
name: PPAP2A

metaM lthstrl r
is: HMDB01170
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189
is: SBO:0000247
is: CHEBI:17168
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
name: 5alpha-cholest-7-en-3beta-ol
constant: false

metaM mthgxl e
type: Species
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
is: CHEBI:17158
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
name: methylglyoxal
is: HMDB01167

metaR DOLPGT2 Uer
reactant: MODEL1310110024#
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110024#
product: MODEL1310110024#
kinetic law: MODEL1310110024#
reversible: false
notes: GENE_ASSOCIATION: (79053.1) or (79053.3) or (79053.2) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
is version of: http://identifiers.org/ec-code/2.4.1.265
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)

http://identifiers.org/biomodels.db/MODEL1310110024#_0d92bd15_3633_43dd_afc5_faffc4138867
name: ATP5H:ATP5L:NSF:ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
has part: P46459
is encoded by: hsa:521
is encoded by: hsa:4905
type: Species
has part: Q6IBB3
initial concentration: NaN
is encoded by: hsa:515
is encoded by: hsa:9551
has part: P56385
is encoded by: hsa:10632
has part: O75964
is encoded by: hsa:522
has only substance units: false
is encoded by: hsa:10476
initial amount: NaN
has part: Q08ET0
is encoded by: hsa:516
boundary condition: true
has part: A0PJH2
has part: P05496
is: SBO:0000297
constant: false

metaM hpyr c
name: 3-hydroxypyruvate
is: CHEBI:17180
constant: false
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01352
notes: FORMULA: C3H3O4 CHARGE: -1 INCHI: InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00163 EHMN_ABBREVIATION: C00168
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110024#_2eac46db_be3b_487a_b4ef_e06ebead0944
initial amount: NaN
type: Species
has only substance units: false
name: VNN3:VNN2:VNN1
is encoded by: hsa:55350
initial concentration: NaN
boundary condition: true
is: SBO:0000297
constant: false

metaM leuktrF4 e
name: leukotriene F4
initial concentration: 1.0
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
boundary condition: false
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
is: CHEBI:27491
is: HMDB06465
has only substance units: false

metaM lnlncg r
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
constant: false
is: HMDB03073
boundary condition: false
name: gamma-linolenate
is: CHEBI:32391
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaR FAOXC183C163Gm
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:3-->C16:3)gm
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_37b3a979_6fb8_43f9_b59c_07903491fe1c
is encoded by: hsa:3283
initial amount: NaN
is: P14060
type: Species
is: SBO:0000252
name: HSD3B1
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_3ca40182_f558_4c36_96f9_53ae10aa97c0
is encoded by: hsa:9487
type: Species
is: Q9Y2B2
constant: false
boundary condition: true
is: SBO:0000252
name: PIGL
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR EX gumgchol LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for guar gum-glycocholate complex
type: Reaction

metaM HC01408 m
is: CHEBI:27648
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
name: 3-Oxohexanoyl-CoA
constant: false

metaM dgmp e
is: CHEBI:57673
has only substance units: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
name: dGMP(2-)
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
is: HMDB01044
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110024#_2b7ef1b9_45eb_4b2f_b488_a3a0822ecec2
initial amount: NaN
is: Q6P1K9
constant: false
name: PANK2
has only substance units: false
type: Species
is encoded by: hsa:80025
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaM fmn e
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C17H19N4O9P CHARGE: -2
name: FMN
has only substance units: false
is: HMDB01520
boundary condition: false
is: SBO:0000247
is: CHEBI:58210
constant: false
is: C00061

metaR MANter
type: Reaction
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110024#
fast: false
name: mannose efflux from endoplasmic reticulum
is: SBO:0000185
product: MODEL1310110024#
kinetic law: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_8c5ed223_2849_401d_8ae0_4b0135d88776
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is: P51688
is encoded by: hsa:6448
type: Species
name: SGSH

metaR ACONT
is described by: ECO:0000134
reversible: true
product: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false
is: SBO:0000176
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/4.2.1.3
type: Reaction
notes: GENE_ASSOCIATION: (3658.1) or (48.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:SMP. Biochemical
modifier: MODEL1310110024#
name: aconitase

metaM dlnlcg c
is: SBO:0000247
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
is: CHEBI:53486
boundary condition: false
type: Species
name: dihomo-gamma-linolenic acid (n-6)
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB02925
initial amount: NaN

metaM apoC Lys btn c
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:32551
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
initial concentration: 1.0
is: HMDB00182
notes: FORMULA: C16H27N4O3SX CHARGE: 0
boundary condition: false
constant: false
is: SBO:0000247

metaR r2141
kinetic law: MODEL1310110024#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110024#
reactant: MODEL1310110024#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
is: SBO:0000185

metaR G14T9g
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
product: MODEL1310110024#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
reversible: false
fast: false
is described by: ECO:0000000

metaR UMPK5n
is described by: ECO:0000269
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110024#
reactant: MODEL1310110024#
reversible: true
name: UMP kinase (dATP),nuclear
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110024#

metaM hco3 c
is: C00288
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
name: Bicarbonate
is: CHEBI:17544
is: HMDB00595
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
constant: false
initial concentration: 1.0

metaM HC02179 c
has only substance units: false
name: 20-hydroxy-arachidonate
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:34306

metaR XOLTRIOLtm
is: SBO:0000185
type: Reaction
name: lipid, flip-flop intracellular transport
reversible: true
fast: false
reactant: MODEL1310110024#
is described by: ECO:0000000
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
product: MODEL1310110024#

metaR DNDPt39m
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
modifier: MODEL1310110024#
is: SBO:0000185
is described by: ECO:0000269
reversible: false
fast: false
reactant: MODEL1310110024#
product: MODEL1310110024#
name: dUTP transport via dGDP antiport

metaR EX cspg a LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan exchange
type: Reaction

metaR HYXNt
product: MODEL1310110024#
fast: false
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
reversible: true
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
type: Reaction
name: Hypoxanthine transport
reactant: MODEL1310110024#

metaM ksi pre32 g
name: keratan sulfate I biosynthesis, precursor 32
constant: false
initial concentration: 1.0
notes: FORMULA: C227H362N16O192S10X CHARGE: -11
is: SBO:0000247
is: CHEBI:28067
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN

metaM leuktrA4 c
name: leukotriene A4(1-)
type: Species
is: HMDB01337
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57463
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909

metaM guln c
type: Species
is: CHEBI:13115
is: HMDB03290
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
initial amount: NaN
name: L-gulonate

http://identifiers.org/biomodels.db/MODEL1310110024#_fb9e9715_9b07_4b39_b1b9_4035ca71860c
type: Species
name: PIP5K1A
is encoded by: hsa:8394
is: Q99755
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false

metaR LDH L
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.27
is described by: ECO:0000000
reactant: MODEL1310110024#
name: L-lactate dehydrogenase
fast: false
product: MODEL1310110024#
reversible: true
modifier: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_919fd8e0_55e0_4442_9ce9_0d14466f5ad6
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: ALDOB
initial concentration: NaN
type: Species
constant: false
is: P05062
is encoded by: hsa:229

http://identifiers.org/biomodels.db/MODEL1310110024#_28fdddee_99df_44cf_97cf_a156d72fc5cb
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
name: HSD17B4
is encoded by: hsa:3295
type: Species
is: SBO:0000252
is: E9PB82

metaR HSAT1ly
is: SBO:0000185
name: heparan-glucosaminide N-acetyltransferase, lysosomal
reversible: false
reactant: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110024#
product: MODEL1310110024#

metaR ACACT1rm
is version of: http://identifiers.org/ec-code/2.3.1.9
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
reactant: MODEL1310110024#
name: acetyl-CoA C-acetyltransferase, mitochondrial
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
is: SBO:0000176
product: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_c329c6f3_ffb5_4f1d_8321_cd9d1341c9de
constant: false
is: Q04828
name: AKR1C1
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1645
type: Species
boundary condition: true
is: SBO:0000252

metaR UGLCNACtg
is: SBO:0000185
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD
fast: false
type: Reaction
kinetic law: MODEL1310110024#
reversible: true
product: MODEL1310110024#
name: UDP-GlcNAc Golgi transport via CMP antiport
is described by: ECO:0000269
modifier: MODEL1310110024#
reactant: MODEL1310110024#

metaR r0679
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
modifier: MODEL1310110024#
reactant: MODEL1310110024#
product: MODEL1310110024#
reversible: true
is described by: ECO:0000000
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33

metaR r2140
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
reactant: MODEL1310110024#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110024#
modifier: MODEL1310110024#
is: SBO:0000185
kinetic law: MODEL1310110024#
fast: false
type: Reaction

metaM dgmp c
is: CHEBI:57673
is: HMDB01044
name: dGMP
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
is: C00362
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_8b78c429_8123_41f5_a11c_5a623ab8fac8
name: DUOX1
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: Q9NRD9
type: Species
has only substance units: false
is encoded by: hsa:53905
boundary condition: true
constant: false

metaR PSYTCHe
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: binding of psyllium with taurocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_e0f71e70_6192_4e8d_89fb_294c2083deef
is: B4DUG1
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
name: SLC24A1
is: SBO:0000252
constant: false
is encoded by: hsa:9187
boundary condition: true

metaM HC00319 m
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:30794
name: Malonate
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_c0a47f57_74ed_4ddd_b6e7_ef2ecfedffd6
name: GAPDHS
boundary condition: true
is: O14556
has only substance units: false
is encoded by: hsa:26330
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_3e47d607_4cba_4855_b29b_2088f0624e4c
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
name: PLCD1
has only substance units: false
is: P51178
initial amount: NaN
is encoded by: hsa:5333
constant: false

metaR FAOXC12DCC10DCx
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12DC-->C10DC)x
type: Reaction

metaR r0784
is: SBO:0000176
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
product: MODEL1310110024#
modifier: MODEL1310110024#
reactant: MODEL1310110024#
fast: false
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.3.1.38
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
reversible: true
type: Reaction
is described by: ECO:0000000

metaR C9BRxtc
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of dimethylnonanoylcarnitine from peroxisomes to cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_6f69bdfb_9227_4168_a951_162852363fd5
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:2544
is: SBO:0000252
has only substance units: false
name: _2544_1_c
boundary condition: true
initial amount: NaN

metaR CHOLPtg
product: MODEL1310110024#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - no strong evidence to indicate further lysosomal or golgi metabolism NJ
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110024#
name: choline phosphate intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110024#_e60a73c8_7c59_4d32_bc82_f1e4e0ea8832
name: ALG5
boundary condition: true
has only substance units: false
is encoded by: hsa:29880
is: Q9Y673
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_d1cf4c5b_a281_47e8_b924_5549d24cfe2b
type: Species
name: PIP4K2A
initial concentration: NaN
is: SBO:0000252
is: P48426
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:5305
initial amount: NaN

metaM malcoa r
name: malonyl-CoA(4-)
is: CHEBI:57384
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB01175
constant: false

metaR RE2660C
fast: false
type: Reaction
is: SBO:0000176
name: RE2660
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
product: MODEL1310110024#
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000000
reversible: true

metaR TRPHYDRO2
reversible: false
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
is described by: ECO:0000269
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (7166.1) or (121278.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.16.4 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:12379098 NOTES:SAB unlumped version of TRPHYDRO1
reactant: MODEL1310110024#
is: SBO:0000176
fast: false
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.14.16.4
modifier: MODEL1310110024#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_feb176b3_5426_4818_8dda_c7e577824265
initial concentration: NaN
constant: false
boundary condition: true
name: _R33828_1_c
is: SBO:0000252
has only substance units: false
is encoded by: hsa:R33828
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_7f3def4e_3621_4afe_8625_d1d6d6c24c1b
initial amount: NaN
is encoded by: hsa:6580
is: SBO:0000252
boundary condition: true
is: O15245
initial concentration: NaN
constant: false
name: SLC22A1
has only substance units: false
type: Species

metaM formcoa c
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:57376
name: formyl-CoA(4-)
notes: FORMULA: C22H32N7O17P3S CHARGE: -4 INCHI: InChI=1S/C22H36N7O17P3S/c1-22(2,17(33)20(34)25-4-3-13(31)24-5-6-50-11-30)8-43-49(40,41)46-48(38,39)42-7-12-16(45-47(35,36)37)15(32)21(44-12)29-10-28-14-18(23)26-9-27-19(14)29/h9-12,15-17,21,32-33H,3-8H2,1-2H3,(H,24,31)(H,25,34)(H,38,39)(H,40,41)(H2,23,26,27)(H2,35,36,37)/p-4/t12-,15-,16-,17+,21-/m1/s1 EHMN_ABBREVIATION: C00798
is: HMDB03419
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_ca4b1afa_d0c6_4aef_9f8d_2ed96f9936bb
is encoded by: hsa:100128062
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
name: _100128062_1_m
boundary condition: true
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_0e1af8b4_5542_44c4_9cbc_e2a99fc158ca
type: Species
has only substance units: false
constant: false
name: SLC26A6
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: Q9Y3Y1
initial amount: NaN
is encoded by: hsa:65010

http://identifiers.org/biomodels.db/MODEL1310110024#_1cd0e793_623b_446c_87b6_283bde5775f6
is encoded by: hsa:64078
initial concentration: NaN
boundary condition: true
constant: false
type: Species
name: SLC28A3
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: Q9HAS3

metaR r2142
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
fast: false
modifier: MODEL1310110024#
reversible: true
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110024#

metaR r1628
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110024#
is: SBO:0000185
kinetic law: MODEL1310110024#
is described by: ECO:0000000
product: MODEL1310110024#
reversible: true
type: Reaction

metaR CHSTEROLtrc
type: Reaction
name: transport of cholesterol into the cytosol
reactant: MODEL1310110024#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
reversible: true
product: MODEL1310110024#
is described by: ECO:0000134
kinetic law: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_6da38a46_afa9_40c0_af32_bd0ca7fc705f
has only substance units: false
type: Species
is encoded by: hsa:6484
boundary condition: true
is: Q6IBE6
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
name: ST3GAL4

http://identifiers.org/biomodels.db/MODEL1310110024#_ec82eea4_f14d_41f7_a847_ecc070e52aa1
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: DGUOK
is encoded by: hsa:1716
is: E5KSL6
constant: false
boundary condition: true

metaM ade e
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:16708
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
name: adenine
type: Species
is: HMDB00034
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaM ala B m
constant: false
is: HMDB00056
type: Species
initial concentration: 1.0
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
boundary condition: false
name: beta-alanine
initial amount: NaN
is: CHEBI:16958
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110024#_ba357e0d_d8d3_4543_8677_f904a361af43
initial amount: NaN
type: Species
is encoded by: hsa:522
initial concentration: NaN
name: ATP5J
is: Q6IB54
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR H6ET3er
fast: false
product: MODEL1310110024#
name: H6 phosphoethanolaminyl transferase, endoplasmic reticulum
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (84720.2) and (5281.1) or (84720.1) and (5281.2) or (5281.1) and (84720.1) or (84720.2) and (5281.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10781593,PMID:8463218 NOTES:NCD
reactant: MODEL1310110024#
modifier: MODEL1310110024#
type: Reaction
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.7.8.1
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110024#_e524529c_3313_4da3_9cce_8882f50af9f9
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:1119
has only substance units: false
boundary condition: true
name: CHKA
initial concentration: NaN
is: SBO:0000252
is: P35790

metaR HOMt4
is: SBO:0000185
name: L-homoserine via sodium symport
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (6541.1) or (84889.1) or (6542.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
reversible: false
fast: false
product: MODEL1310110024#
is described by: ECO:0000269
type: Reaction

metaM hco3 m
initial amount: NaN
is: C00288
initial concentration: 1.0
has only substance units: false
constant: false
name: Bicarbonate
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB00595
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: CHEBI:17544

http://identifiers.org/biomodels.db/MODEL1310110024#_0b32624e_7d04_4496_b213_0f6c29a2e03c
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
name: ACADM
initial concentration: NaN
has only substance units: false
boundary condition: true
is: P11310
is encoded by: hsa:34

metaR DAGK hs
product: MODEL1310110024#
modifier: MODEL1310110024#
name: Diacylglycerol phosphate kinase (homo sapiens)
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.107
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110024#
reversible: true
reactant: MODEL1310110024#

metaM leuktrA4 e
constant: false
name: leukotriene A4(1-)
initial amount: NaN
has only substance units: false
is: CHEBI:57463
is: HMDB01337
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909

metaR r1627
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110024#
reversible: true
reactant: MODEL1310110024#
is: SBO:0000185
product: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM hs deg12 l
initial amount: NaN
has only substance units: false
is: CHEBI:17180
constant: false
name: heparan sulfate, degradation product 12
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C55H82N3O64S6 CHARGE: -7
is: SBO:0000247
is: HMDB01352

metaM dhcholestanate m
initial amount: NaN
is: HMDB00359
constant: false
initial concentration: 1.0
is: CHEBI:16577
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554

metaR r1797
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: false
is: SBO:0000185
product: MODEL1310110024#
reactant: MODEL1310110024#
fast: false
modifier: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_49f3b180_069d_45df_86bb_d99a7fa276b0
name: NDUFS1
initial concentration: NaN
constant: false
is: P28331
is encoded by: hsa:4719
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_d4dfdf8e_0361_46e9_b949_82cf63e90254
has only substance units: false
type: Species
name: _AA419122_1_c
initial amount: NaN
is encoded by: hsa:AA419122
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaM lnlncgcoa c
is: HMDB06368
type: Species
is: CHEBI:57363
name: gamma-linolenoyl-CoA(4-)
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
initial concentration: 1.0
is: SBO:0000247
constant: false

metaM 3ddecdicoa m
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
has only substance units: false
is: HMDB03952
initial concentration: 1.0
is: C05280
boundary condition: false
name: 3,6-dodecadienoylcoa
constant: false

metaR r1466
is: SBO:0000176
reversible: true
product: MODEL1310110024#
fast: false
type: Reaction
reactant: MODEL1310110024#
name: EC:2.3.1.86
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000

metaR AG13T10g
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
type: Reaction
is: SBO:0000176
fast: false
reversible: false
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10331.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110024#
is described by: ECO:0000000
modifier: MODEL1310110024#

metaR RE3244R
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000000
name: RE3244
reversible: true
product: MODEL1310110024#
type: Reaction
is: SBO:0000176
fast: false

metaR EX CE5789 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-8 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_bc36951e_6645_4317_bd35_bd4ced43a23b
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:5291
is: SBO:0000252
name: PIK3CB
constant: false
boundary condition: true
type: Species
is: B4DER4

metaM ade c
is: C00147
name: Adenine
type: Species
is: HMDB00034
is: CHEBI:16708
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_6a1be4de_9905_45e6_8a4a_b63d8f9c64b8
is encoded by: hsa:2348
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
name: FOLR1

metaR SERDGLNexR
name: D-Serine/Glutamine reversible exchange
kinetic law: MODEL1310110024#
reversible: true
fast: false
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
is: SBO:0000185
reactant: MODEL1310110024#
modifier: MODEL1310110024#
type: Reaction

metaM gtp e
is: CHEBI:37565
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
name: GTP(4-)
boundary condition: false
is: HMDB01273
has only substance units: false
constant: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044

metaM HC02187 c
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
is: SBO:0000247
type: Species
name: reverse-triiodthyronine
has only substance units: false
is: CHEBI:28774

http://identifiers.org/biomodels.db/MODEL1310110024#_6f2a8fe4_81c9_48ec_8868_501d238bfe82
is encoded by: hsa:22978
name: NT5C2
constant: false
has only substance units: false
initial concentration: NaN
is: P49902
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species

metaR GALASE11ly
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110024#
name: beta-galactosidase, lysosomal
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110024#_ef53f493_a882_4b3f_8f32_ac81b40d7b19
boundary condition: true
is encoded by: hsa:8802
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
name: SUCLG1
has only substance units: false
is: P53597

metaR r1629
is described by: ECO:0000000
fast: false
reactant: MODEL1310110024#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110024#
type: Reaction
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110024#_dedcc0ac_c83f_4eab_91b0_097eaa9b338f
has only substance units: false
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:2530
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: FUT8
is: G3V5N0

metaR NADtn
reactant: MODEL1310110024#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
name: NAD transport, nuclear through pores
fast: false
type: Reaction
product: MODEL1310110024#
is: SBO:0000185
kinetic law: MODEL1310110024#

metaM atp x
is: SBO:0000247
initial amount: NaN
constant: false
name: ATP(4-)
type: Species
has only substance units: false
is: C00002
is: HMDB00538
initial concentration: 1.0
boundary condition: false
is: CHEBI:57299

http://identifiers.org/biomodels.db/MODEL1310110024#_2e05f174_d022_4c87_b1da_0c5c6ca62414
is: SBO:0000252
constant: false
has only substance units: false
name: PLCB4
is encoded by: hsa:5332
is: E2QRH8
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_27ff1c25_8417_416f_8ae3_08ff0f836dfc
constant: false
is: SBO:0000252
is encoded by: hsa:56848
initial concentration: NaN
name: SPHK2
is: Q9NRA0
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false

metaR r1464
reversible: true
name: Active transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110024#
fast: false
kinetic law: MODEL1310110024#
is: SBO:0000185
product: MODEL1310110024#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110024#_5d048929_302d_4c4d_9c19_7b90b696362a
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:728441
name: GGT2

http://identifiers.org/biomodels.db/MODEL1310110024#_76cb5d5d_01a7_4c17_bb9c_beaacc435738
is: SBO:0000252
boundary condition: true
constant: false
name: ADH1C
is encoded by: hsa:126
initial concentration: NaN
initial amount: NaN
type: Species
is: P00326
has only substance units: false

metaR THBPT4ACAMDASE
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000269
reversible: false
type: Reaction
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
is version of: http://identifiers.org/ec-code/4.2.1.96
fast: false
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
is: SBO:0000176

metaR GLYCt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110024#
reactant: MODEL1310110024#
name: glycerol transport via channel
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110024#
fast: false
type: Reaction

metaR ME1m
reversible: false
name: malic enzyme (NAD), mitochondrial
type: Reaction
is: SBO:0000176
reactant: MODEL1310110024#
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.1.1.38
notes: GENE_ASSOCIATION: (4200.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110024#
fast: false
modifier: MODEL1310110024#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110024#_16044081_eec1_4934_b1cb_b71a41a6224e
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:AI656480
initial amount: NaN
initial concentration: NaN
name: _AI656480_1_m

metaR r1624
type: Reaction
reversible: true
product: MODEL1310110024#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110024#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110024#
fast: false
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR Q10H2e
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.
reversible: true
is described by: ECO:0000134
product: MODEL1310110024#
is: SBO:0000185
reactant: MODEL1310110024#
name: transport of ubiquinol into lymph
fast: false
type: Reaction

metaM adrn e
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
constant: false
has only substance units: false
initial amount: NaN
is: HMDB02226
is: CHEBI:53487
name: adrenic acid
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_8d0d8f7d_ceaf_4d47_b5b9_165bef3c79cd
boundary condition: true
is encoded by: hsa:7001
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
name: PRDX2
type: Species

metaM ksi l
name: keratan sulfate I
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
is: CHEBI:57455
initial amount: NaN
has only substance units: false
is: C00445
is: HMDB01354
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaR r0791
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is described by: ECO:0000000
reactant: MODEL1310110024#
is: SBO:0000176
reversible: true
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
kinetic law: MODEL1310110024#
type: Reaction

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_9df1c812_93dd_4268_9b45_b78b301c8fc1
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:9551
has part: P56134
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
boundary condition: true
has only substance units: false
is encoded by: hsa:522
type: Species

metaR CYTK1m
fast: false
name: cytidylate kinase (CMP),mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:No evidence in the mitochondrion
kinetic law: MODEL1310110024#
is described by: ECO:0000134
type: Reaction
is: SBO:0000176
reversible: true
reactant: MODEL1310110024#
product: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_4c9ae618_2f52_4a78_902d_881284076a2d
is: P17516
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
name: AKR1C4
is encoded by: hsa:1109
boundary condition: true
is: SBO:0000252
constant: false

metaR r1623
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
modifier: MODEL1310110024#
reactant: MODEL1310110024#
product: MODEL1310110024#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110024#
reversible: true
is: SBO:0000185
type: Reaction

metaR G13MT L
name: Glycolipid 1,3-alpha-D-mannosyltransferase (liver)
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.132
reactant: MODEL1310110024#
fast: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110024#
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (85365.1) or (85365.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.132 Confidence Level: 0 AUTHORS: NOTES:NCD

metaR r1731
reactant: MODEL1310110024#
is: SBO:0000185
reversible: false
product: MODEL1310110024#
is described by: ECO:0000000
kinetic law: MODEL1310110024#
name: Y+LAT2 Utilized transport
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110024#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_e76ea5b3_f78a_4ea8_89aa_d113a717db13
type: Species
boundary condition: true
is: SBO:0000252
is: Q9BVG9
name: PTDSS2
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:81490
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_779d33ee_cb7b_4301_9077_0514f614d75d
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
name: ATP1A3
type: Species
is encoded by: hsa:478
boundary condition: true
is: SBO:0000252
is: B7Z2T0

metaM glyc3p c
initial concentration: 1.0
is: SBO:0000247
name: Glycerol 3-phosphate
initial amount: NaN
is: C00093
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
has only substance units: false
is: HMDB00126
is: CHEBI:57597
type: Species
constant: false
boundary condition: false

metaM psyltchol e
name: psyllium-taurocholic acid complex
has only substance units: false
is: http://identifiers.org/pubchem.compound/94244
notes: FORMULA: C9642032H15428745NO8667421S CHARGE: 0
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false

metaM CE5118 m
name: trans-2-cis,cis-4,8-tetradecatrienoyl-CoA
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:57923
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,12-15,22-24,28-30,34,45-46H,4-7,10-11,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,13-12-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5118
initial amount: NaN
constant: false
initial concentration: 1.0

metaM HC01397 m
initial concentration: 1.0
is: CHEBI:27402
name: (S)-3-Hydroxyhexadecanoyl-CoA
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
constant: false

metaM 10fthf c
boundary condition: false
is: SBO:0000247
is: C00234
is: CHEBI:57454
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: HMDB00972
initial amount: NaN
name: 10-Formyltetrahydrofolate
has only substance units: false
initial concentration: 1.0
type: Species
constant: false

metaR CYTK1n
reactant: MODEL1310110024#
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP),nuclear
modifier: MODEL1310110024#
fast: false
type: Reaction
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110024#
is described by: ECO:0000269

metaM adrn c
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
constant: false
initial amount: NaN
name: adrenic acid
is: CHEBI:53487
is: HMDB02226
type: Species
is: SBO:0000247

metaR AMPTASECGe
is: SBO:0000176
name: alanyl aminopeptidase (cys-gly) (e)
type: Reaction
reactant: MODEL1310110024#
reversible: false
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (290.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.2 Confidence Level: 4 AUTHORS: PMID:6126478 NOTES:SAB. rat lumen renal proximal tubule preparation cysteinylglycine metabolism measured due to aminopeptidase M (=N); the annotation in BiGG of strong biochemical evidence in a textbook could not be found in the Google Books version search of this book; intensively sought for human metabolism; human metabolism is likely though not proven directly
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.4.11.2
kinetic law: MODEL1310110024#
fast: false
product: MODEL1310110024#

metaR r1626
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110024#
product: MODEL1310110024#
kinetic law: MODEL1310110024#
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110024#
reversible: true
type: Reaction

metaR DURAD2
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.3.1.2
product: MODEL1310110024#
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
reversible: true
type: Reaction
fast: false
is: SBO:0000176
name: dihydrothymin dehydrogenase (NADP)
is described by: ECO:0000269

metaR CYOOm3
product: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
reversible: false
is version of: http://identifiers.org/ec-code/1.9.3.1
is described by: ECO:0000134
type: Reaction
is: SBO:0000185
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
name: cytochrome c oxidase, mitochondrial Complex IV
modifier: MODEL1310110024#

metaM m2mpdol L c
type: Species
constant: false
initial amount: NaN
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
has only substance units: false
is: CHEBI:28049
boundary condition: false
notes: FORMULA: C1420H2328N20O320P20 CHARGE: -20
initial concentration: 1.0
is: SBO:0000247

metaR r1730
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
reactant: MODEL1310110024#
is: SBO:0000185
reversible: false
product: MODEL1310110024#

metaR FAOXC2051843x
is described by: ECO:0000269
type: Reaction
name: Beta oxidation of long chain fatty acid
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (30.1 and 51.2 and 1962.1) or (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110024#

metaR LDH D
reactant: MODEL1310110024#
is: SBO:0000176
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)
type: Reaction
modifier: MODEL1310110024#
fast: false
is version of: http://identifiers.org/ec-code/1.1.2.4
name: D-lactate dehydrogenase
reversible: true
is described by: ECO:0000304
kinetic law: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_d79fd884_6217_4493_b72b_8bd4f4a3e354
name: PLCG2
boundary condition: true
is: SBO:0000252
type: Species
constant: false
is: P16885
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5336

http://identifiers.org/biomodels.db/MODEL1310110024#_c72fb490_7f12_4393_a1b1_b2ae6929e4a9
constant: false
has only substance units: false
is: A8DPS7
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: PAFAH1B2
initial concentration: NaN
type: Species
is encoded by: hsa:5049

http://identifiers.org/biomodels.db/MODEL1310110024#_c4ac69bb_ac44_41d9_9eca_0431e892ca99
constant: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:10449
name: ACAA2
initial concentration: NaN
is: P42765
has only substance units: false
is: SBO:0000252

metaM decdp m
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
name: all trans Decaprenyl diphosphate
boundary condition: false
is: HMDB06288
notes: FORMULA: C50H81O7P2 CHARGE: -3 INCHI: InChI=1/C50H90O7P2/c1-41(2)21-31-53-58(51,54-32-22-42(3)4)57-59(52,35-25-45(9)10,36-26-46(11)12,37-27-47(13)14,38-28-48(15)16,39-29-49(17)18,40-30-50(19)20,55-33-23-43(5)6)56-34-24-44(7)8/h21-30H,31-40H2,1-20H3
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_0016bdb4_570d_4c98_ba9b_ceece2ebc302
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
is: P33316
name: DUT
is encoded by: hsa:1854
initial concentration: NaN
type: Species

metaR r1625
fast: false
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110024#
product: MODEL1310110024#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction
reversible: true
kinetic law: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_185da507_54e9_4abd_8003_32027cad2b89
is: P31213
has only substance units: false
is encoded by: hsa:6716
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: SRD5A2
constant: false

metaR DNDPt24m
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
name: dTDP transport via dADP antiport
reversible: false
is: SBO:0000185
reactant: MODEL1310110024#
is described by: ECO:0000269
product: MODEL1310110024#

metaR ALAGLYexR
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
name: L-alanine/glycine reversible exchange
is: SBO:0000185
is described by: ECO:0000304
product: MODEL1310110024#
fast: false
type: Reaction
modifier: MODEL1310110024#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110024#_a035535a_bb09_4dcc_b496_3c550f877052
boundary condition: true
has only substance units: false
name: UPP1
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
is: Q16831
type: Species
is encoded by: hsa:7378

metaM bildglcur e
is: HMDB03325
name: bis(beta-glucosyluronate)bilirubin
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
initial concentration: 1.0
is: CHEBI:58471
is: SBO:0000247

metaR EX orot LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of orotate
type: Reaction

metaR SACCD4m
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.1.10 Confidence Level: 4 AUTHORS: PMID:10775527 NOTES:MM
reversible: false
is: SBO:0000176
modifier: MODEL1310110024#
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.5.1.8
kinetic law: MODEL1310110024#
is described by: ECO:0000269
reactant: MODEL1310110024#
fast: false
type: Reaction
name: saccharopine dehydrogenase (NAD, L-glutamate forming), mitochondrial

metaR MECOALm
type: Reaction
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
is version of: http://identifiers.org/ec-code/6.2.1.4
is version of: http://identifiers.org/ec-code/6.2.1.5
reversible: true
kinetic law: MODEL1310110024#
is described by: ECO:0000212
product: MODEL1310110024#
fast: false
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_596f42ed_0924_469e_97de_7d3967a09ac3
name: AK2
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: P54819
type: Species
is encoded by: hsa:204
constant: false

metaM lnlncg e
has only substance units: false
initial amount: NaN
type: Species
name: gamma-linolenate
is: HMDB03073
is: SBO:0000247
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
is: CHEBI:32391
initial concentration: 1.0
constant: false
boundary condition: false

metaR C6DCc
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of adipoylcarnitine
type: Reaction

metaR C12DCTD
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Dodecanedioic acid by diffusion
type: Reaction

metaR r1620
product: MODEL1310110024#
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110024#

metaR VALt5m
is: SBO:0000185
reversible: true
name: Valine reversible mitochondrial transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
is described by: ECO:0000000
kinetic law: MODEL1310110024#
type: Reaction
reactant: MODEL1310110024#
product: MODEL1310110024#
fast: false

metaM 3sala c
name: 3-Sulfino-L-alanine
initial amount: NaN
is: C00606
type: Species
is: SBO:0000247
notes: FORMULA: C3H5NO4S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
boundary condition: false
initial concentration: 1.0
is: CHEBI:61085
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_c393db42_92dd_4c43_b331_9f0136cf0c68
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:89869
boundary condition: true
has only substance units: false
is: Q86YW0
initial amount: NaN
name: PLCZ1
is: SBO:0000252

metaM 5hoxindact c
name: (5-hydroxyindol-3-yl)acetaldehyde
type: Species
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C10H9NO2 CHARGE: 0 INCHI: InChI=1S/C10H9NO2/c12-4-3-7-6-11-10-2-1-8(13)5-9(7)10/h1-2,4-6,11,13H,3H2 HEPATONET_1.0_ABBREVIATION: HC01536 EHMN_ABBREVIATION: C05634
is: CHEBI:50157
is: HMDB04073
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaR 5AOPtm
reversible: true
type: Reaction
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10558864 NOTES:NCD. Delta-aminolevulinic acid is produced in mitochondria then converted to PBG in the cytoplasm. Could not find anything on the transporter itself.
name: 5-Aminolevulinate mitochondrial transport
is: SBO:0000185
kinetic law: MODEL1310110024#
is described by: ECO:0000134
reactant: MODEL1310110024#
fast: false

metaR EX glygn4 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_ce714817_acef_4f92_85ef_b266ffbc2df3
is: SBO:0000252
is encoded by: hsa:6550
boundary condition: true
has only substance units: false
is: P48764
constant: false
initial amount: NaN
type: Species
name: SLC9A3
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_c0f20071_c1db_40dd_aab4_2f880b1aa594
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4708
name: NDUFB2
type: Species
initial amount: NaN
is: H7C5B8

metaR NDPK9n
product: MODEL1310110024#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
fast: false
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear
reversible: true

metaM dopasf c
is: HMDB06275
is: SBO:0000247
initial amount: NaN
is: CHEBI:37946
boundary condition: false
name: dopamine 3-O-sulfate
initial concentration: 1.0
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_dc26f1dc_59ad_4758_865e_ebb76c275e9d
is: SBO:0000252
initial concentration: NaN
is: B4DR31
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:1808
constant: false
name: DPYSL2

metaM malt e
type: Species
initial concentration: 1.0
initial amount: NaN
is: C00208
is: HMDB00163
name: Maltose
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00194 EHMN_ABBREVIATION: C00208
is: SBO:0000247
is: CHEBI:17306
boundary condition: false
constant: false
has only substance units: false

metaM taur c
has only substance units: false
initial amount: NaN
type: Species
is: C00245
boundary condition: false
is: CHEBI:3544
is: HMDB00251
is: SBO:0000247
name: Taurine
notes: FORMULA: C2H7NO3S CHARGE: 0
constant: false
initial concentration: 1.0

metaM ksi deg30 l
is: CHEBI:12936
boundary condition: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 30
initial amount: NaN
constant: false
notes: FORMULA: C90H147N6O75S3 CHARGE: -3
is: HMDB00143
has only substance units: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110024#_9fccdd03_dff1_4971_a502_1fa84b4e0d52
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:5373
name: PMM2
is: O15305
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_e0bbdaa8_f098_432f_9d3b_82dbef3f0afb
is: E9PAY8
is: SBO:0000252
initial concentration: NaN
name: PPAP2C
initial amount: NaN
has only substance units: false
constant: false
type: Species
boundary condition: true
is encoded by: hsa:8612

metaM bildglcur c
is: CHEBI:58471
is: SBO:0000247
boundary condition: false
is: HMDB03325
has only substance units: false
constant: false
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
initial amount: NaN
initial concentration: 1.0
type: Species
name: bis(beta-glucosyluronate)bilirubin

metaR FACOAL150
product: MODEL1310110024#
reversible: true
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
is described by: ECO:0000000
name: fatty-acid--CoA ligase
type: Reaction
modifier: MODEL1310110024#
is: SBO:0000176
kinetic law: MODEL1310110024#

metaR r1622
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110024#
is described by: ECO:0000000
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false
product: MODEL1310110024#

metaR r0908
reactant: MODEL1310110024#
product: MODEL1310110024#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
is: SBO:0000185
name: Postulated transport reaction
type: Reaction
reversible: true
kinetic law: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_729d1bbc_ee99_4c6e_9730_905f5a31d4cc
is encoded by: hsa:518
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
name: ATP5G3
is: P48201
has only substance units: false
type: Species
is: SBO:0000252

metaM pan4p m
is: CHEBI:47942
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB01416
initial amount: NaN
constant: false
name: pantetheine 4'-phosphate(2-)
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134

metaR ASPDxt
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:MM
is: SBO:0000185
product: MODEL1310110024#
fast: false
name: D-aspartate transport, peroxisomal
reactant: MODEL1310110024#
reversible: true
is described by: ECO:0000000
type: Reaction

metaM atp m
boundary condition: false
is: C00002
initial concentration: 1.0
is: CHEBI:57299
initial amount: NaN
has only substance units: false
is: HMDB00538
constant: false
is: SBO:0000247
name: ATP(4-)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_44b127cd_1ac4_4fe6_8259_d79e0f671424
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6482
constant: false
is: Q11201
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
name: ST3GAL1

metaM ksi deg37 l
constant: false
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:57455
name: keratan sulfate I, degradation product 37
initial concentration: 1.0
is: HMDB01354
notes: FORMULA: C62H104N4O46 CHARGE: 0

metaM c14dccoa x
is: HMDB02288
is: SBO:0000247
constant: false
type: Species
boundary condition: false
initial amount: NaN
name: tetradecanedioylcoa
notes: FORMULA: C35H55N7O19P3S CHARGE: -5
has only substance units: false
initial concentration: 1.0

metaM atp n
type: Species
boundary condition: false
name: ATP(3-)
constant: false
is: CHEBI:57299
initial amount: NaN
is: HMDB00538
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002

metaM phaccoa c
name: phenylacetyl-CoA(4-)
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:57390
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB06503
notes: FORMULA: C29H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H42N7O17P3S/c1-29(2,24(40)27(41)32-9-8-19(37)31-10-11-57-20(38)12-17-6-4-3-5-7-17)14-50-56(47,48)53-55(45,46)49-13-18-23(52-54(42,43)44)22(39)28(51-18)36-16-35-21-25(30)33-15-34-26(21)36/h3-7,15-16,18,22-24,28,39-40H,8-14H2,1-2H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/p-4/t18-,22-,23-,24+,28-/m1/s1

metaM lnlncg c
is: CHEBI:32391
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
is: HMDB03073
name: gamma-linolenate

http://identifiers.org/biomodels.db/MODEL1310110024#_4ef8a7b8_97df_4061_8cab_3d4f7ff113d1
initial concentration: NaN
name: OCRL
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:4952
is: Q01968
constant: false
is: SBO:0000252
has only substance units: false

metaM psyl e
constant: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/94244
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9642006H15428700O8667414 CHARGE: 0
type: Species
name: psyllium
has only substance units: false

metaR r0909
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
reversible: true
type: Reaction
reactant: MODEL1310110024#
product: MODEL1310110024#
fast: false
name: Transport reaction
is: SBO:0000185
is described by: ECO:0000000

metaR r1734
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false
reactant: MODEL1310110024#
is: SBO:0000185
type: Reaction
reversible: false

metaR r0680
type: Reaction
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.137
modifier: MODEL1310110024#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
product: MODEL1310110024#
reactant: MODEL1310110024#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
kinetic law: MODEL1310110024#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110024#_8d6e1bb8_93f2_48e9_9eb0_7613b0650499
constant: false
name: BTD
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
is: P43251
is encoded by: hsa:686
initial concentration: NaN
initial amount: NaN

metaM dopasf e
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:37946
boundary condition: false
constant: false
name: dopamine 3-O-sulfate
type: Species
initial concentration: 1.0
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
is: HMDB06275

http://identifiers.org/biomodels.db/MODEL1310110024#_3cbecb1f_32c5_4e95_af9a_7d791d908a18
has only substance units: false
type: Species
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:515
is: SBO:0000297

metaR r1621
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110024#
modifier: MODEL1310110024#
type: Reaction
product: MODEL1310110024#
kinetic law: MODEL1310110024#
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110024#_21d3b3ad_be42_4487_800b_e7460b2be147
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:594
type: Species
has only substance units: false
is: Q9BQL0
name: BCKDHB
boundary condition: true
is: SBO:0000252
constant: false

metaM lald L c
is: CHEBI:18041
initial amount: NaN
type: Species
name: (S)-lactaldehyde
boundary condition: false
initial concentration: 1.0
is: HMDB03052
constant: false
has only substance units: false
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m0/s1
is: SBO:0000247

metaM taur e
initial concentration: 1.0
is: C00245
type: Species
has only substance units: false
is: CHEBI:3544
boundary condition: false
is: HMDB00251
is: SBO:0000247
constant: false
name: Taurine
initial amount: NaN
notes: FORMULA: C2H7NO3S CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110024#_cb349286_2284_470e_be00_7457ece90da9
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1543
name: CYP1A1
is: A0N0X8
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
constant: false

metaR CYSTS
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/4.2.1.22
fast: false
type: Reaction
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
is described by: ECO:0000269
product: MODEL1310110024#
is: SBO:0000176
notes: GENE_ASSOCIATION: (875.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 4.2.1.22 Confidence Level: 4 AUTHORS: PMID:681363,PMID:9790750 NOTES:NCD
name: cystathionine beta-synthase
reversible: false

metaR PRISTCOAtcx
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of pristanoylcoa from cytosol to peroxisomes.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_a026b710_bad0_4469_8bc5_14f2be09ddb3
initial concentration: NaN
has only substance units: false
name: GLRX2
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:51022

http://identifiers.org/biomodels.db/MODEL1310110024#_fb660f5b_dcf8_4da0_bd84_f86ef0c6125f
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AI924226
initial concentration: NaN
type: Species
name: _AI924226_1_m
has only substance units: false
initial amount: NaN

metaR DHORD9
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (1723.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 1.3.3.1 Confidence Level: 4 AUTHORS: PMID:10727948,PMID:9693067 NOTES:_06-15-05 - EC 1.3.3.1 IT based on Bader et al, 1998, Prot. Expr. Purif,., 13,414-422 (I guess it is ubiquinone but i am not sure ) (needs FMN as cofactor) v(enzyme is located in inner-membrane of mitochondria, reaction take place in cytosol (Fig. 8 Rawls et al PMID: 10727948 )
is version of: http://identifiers.org/ec-code/1.3.5.2
is: SBO:0000185
product: MODEL1310110024#
reversible: false
fast: false
type: Reaction
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
name: dihydoorotic acid dehydrogenase (quinone10)
is described by: ECO:0000269

metaR GALASE6ly
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110024#
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110024#
reversible: false
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110024#
name: beta-galactosidase, lysosomal

metaR CYTDt
type: Reaction
reversible: true
is: SBO:0000185
fast: false
name: cytidine facilated transport in cytosol
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000269
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
kinetic law: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_a693ed7d_0d91_445f_8600_35d03544836c
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
name: MAN1A2
boundary condition: true
is encoded by: hsa:10905
is: O60476
is: SBO:0000252
type: Species

metaR EX HC02204 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b1 exchange
type: Reaction

metaM glutcoa m
name: glutaryl-CoA(5-)
constant: false
is: HMDB01339
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57378
type: Species
initial amount: NaN
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
boundary condition: false
has only substance units: false

metaR ABTArm
modifier: MODEL1310110024#
fast: false
name: 4-aminobutyrate transaminase, reversible (mitochondrial)
kinetic law: MODEL1310110024#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Glutamate metabolism EC Number: 2.6.19.4 Confidence Level: 4 AUTHORS: PMID:10407778,PMID:7721088 NOTES:kh 1/6/03
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.19
product: MODEL1310110024#
reactant: MODEL1310110024#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_2c7b8313_0230_4b09_b248_03a131cd57d0
is: P11169
name: SLC2A3
is: SBO:0000252
is encoded by: hsa:6515
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false

metaM thcrm hs g
name: trihexosyl ceramide
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C36H66NO17FULLRCO CHARGE: 0
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:24636

metaR PGLYCt
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
type: Reaction
is: SBO:0000185
name: phosphatidylglycerol transport
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 3.1.3.18 Confidence Level: 2 AUTHORS: PMID:2164460,PMID:6290284 NOTES:
product: MODEL1310110024#
is described by: ECO:0000269

metaR r1736
fast: false
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110024#
modifier: MODEL1310110024#
reversible: false
product: MODEL1310110024#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110024#_825123fe_5557_44df_a725_72c509c52f4e
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: P32322
initial amount: NaN
name: PYCR1
boundary condition: true
is encoded by: hsa:5831

metaR FOLt2le
kinetic law: MODEL1310110024#
fast: false
is described by: ECO:0000134
is: SBO:0000185
name: folate transport via anion exchange
reactant: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110024#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110024#_d42f129f_b8d0_41f7_9aee_c3dc8b6ae160
is: P23921
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:6240
name: RRM1

metaM dhf m
boundary condition: false
type: Species
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
is: HMDB01056
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:57451
name: dihydrofolate(2-)
initial concentration: 1.0

metaM HC02187 e
type: Species
initial concentration: 1.0
name: reverse-triiodthyronine
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:28774
boundary condition: false
constant: false

metaM gtp c
type: Species
has only substance units: false
name: GTP
constant: false
boundary condition: false
is: C00044
is: CHEBI:37565
is: SBO:0000247
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: HMDB01273
initial amount: NaN
initial concentration: 1.0

metaM 4mzym int1 r
has only substance units: false
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C29H46O3 CHARGE: 0 INCHI: InChI=1/C29H46O3/c1-18(2)8-7-9-19(3)21-11-12-22-20-10-13-24-28(5,23(20)14-16-27(21,22)4)17-15-25(30)29(24,6)26(31)32/h8,19,21-22,24-25,30H,7,9-17H2,1-6H3,(H,31,32)/t19-,21?,22?,24?,25-,27+,28+,29-/m0/s1
name: 4-Methylzymosterol intermediate 1
is: HMDB06927
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR DESAT20 1
reactant: MODEL1310110024#
type: Reaction
reversible: false
name: fatty acyl-CoA desaturase (n-C20:3CoA -> n-C20:4CoA)
kinetic law: MODEL1310110024#
product: MODEL1310110024#
is described by: ECO:0000000
modifier: MODEL1310110024#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
fast: false

metaR HSPASEly
name: heparan sulfate proteoglycan protease, lysosome (endosome)
is: SBO:0000176
fast: false
kinetic law: MODEL1310110024#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:12782143,PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
reactant: MODEL1310110024#
product: MODEL1310110024#
reversible: false

metaR ORNt3m
product: MODEL1310110024#
modifier: MODEL1310110024#
fast: false
kinetic law: MODEL1310110024#
name: ornithine mitochondrial transport via proton antiport
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
reversible: true

metaM ksii core2 deg9 l
is: HMDB00143
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
name: keratan sulfate II (core 2-linked), degradation product 9
initial concentration: 1.0
notes: FORMULA: C30H50N3O20X CHARGE: 0
type: Species
initial amount: NaN
is: CHEBI:12936

metaR r2433
reactant: MODEL1310110024#
reversible: false
kinetic law: MODEL1310110024#
fast: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_c2630108_b15e_4cd7_afe7_2a86c1a14d01
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: ELOVL2
boundary condition: true
constant: false
is: Q9NXB9
type: Species
is encoded by: hsa:54898

metaR NDPK10n
fast: false
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000304
type: Reaction
name: nucleoside-diphosphate kinase (ATP:dIDP), nuclear
is: SBO:0000176
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions. . Presence in the nucleus
kinetic law: MODEL1310110024#
reversible: true
reactant: MODEL1310110024#

metaR G14T13g
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.4.1.38
modifier: MODEL1310110024#
is described by: ECO:0000000
kinetic law: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
product: MODEL1310110024#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

metaR FUCASE2e
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
name: alpha-fucosidase, extracellular
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.51
product: MODEL1310110024#
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:10460218,PMID:11389735,PMID:12604617,PMID:2317201 NOTES:NCD
fast: false

http://identifiers.org/biomodels.db/MODEL1310110024#_4e712698_7b4c_4593_bba6_55143436f26e
is: SBO:0000252
name: _AI620219_1_m
type: Species
boundary condition: true
is encoded by: hsa:AI620219
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN

metaR EX gly LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Glycine
type: Reaction

metaM betald c
is: HMDB01252
is: SBO:0000247
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:15710
name: betaine aldehyde
boundary condition: false
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
initial concentration: 1.0

metaR EX dcyt LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxycytidine
type: Reaction

metaM atp r
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:57299
initial amount: NaN
is: C00002
is: HMDB00538
name: ATP(4-)
has only substance units: false
constant: false

metaM trdox m
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:18191
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
name: Oxidized thioredoxin
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN

metaR GCC2cm
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
name: glycine-cleavage complex (lipoamide), mitochondrial
is: SBO:0000176
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.4.4.2
reactant: MODEL1310110024#
is described by: ECO:0000269
product: MODEL1310110024#
kinetic law: MODEL1310110024#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.1.2.10
is version of: http://identifiers.org/ec-code/1.8.1.4
reversible: true

metaR DESAT20 2
reactant: MODEL1310110024#
fast: false
is described by: ECO:0000000
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
modifier: MODEL1310110024#
product: MODEL1310110024#
kinetic law: MODEL1310110024#
type: Reaction
name: fatty acyl-CoA desaturase (n-C20:4CoA -> n-C20:5CoA)

metaM cit m
is: CHEBI:16947
is: SBO:0000247
name: Citrate
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
type: Species
boundary condition: false
is: HMDB00094
has only substance units: false
constant: false
is: C00158
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110024#_c4da99ac_f1a3_4dfa_975b_1965bffdb366
type: Species
boundary condition: true
constant: false
is encoded by: hsa:AA021081
name: _AA021081_1_r
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaM clpn hs c
constant: false
initial amount: NaN
boundary condition: false
name: cardiolipin
initial concentration: 1.0
type: Species
is: CHEBI:28494
has only substance units: false
notes: FORMULA: C9H16O9P2FULLRCO2FULLR2CO2FULLRCO2FULLR2CO2 CHARGE: -2
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110024#_79f84285_c3f5_43a6_93da_38c86e0625a8
name: SDHB
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6390
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
is: P21912

metaR CORE3GTg
is described by: ECO:0000000
reversible: false
fast: false
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
notes: GENE_ASSOCIATION: (192134.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.147 Confidence Level: 0 AUTHORS: PMID:11821425 NOTES:NCD
name: Core 3 beta-GlcNAc-transferase, Golgi apparatus
is: SBO:0000176

metaM dhcholestanate c
constant: false
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
initial concentration: 1.0
is: HMDB00359
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
is: CHEBI:16577
type: Species

metaM 3hexdtetcoa m
constant: false
type: Species
boundary condition: false
is: HMDB02288
has only substance units: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: 3,7,10,13-hexadecatetraenoylcoa

metaR CSNATr
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:7829107 NOTES:IF
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110024#
name: carnitine O-acetyltransferase
reactant: MODEL1310110024#
is: SBO:0000176
kinetic law: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_2d3a51c8_daf4_4f14_b9af_dce5302c5703
type: Species
is: Q6IRT1
boundary condition: true
name: ADH5
is encoded by: hsa:128
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_55d9b21e_3c5d_4254_ac6a_08658c82eebd
boundary condition: true
name: PI4KB
is: Q9UBF8
has only substance units: false
is encoded by: hsa:5298
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_3bb5f626_506e_47d4_a1a8_256e46ea022a
constant: false
name: ALAD
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:210
has only substance units: false
type: Species
is: SBO:0000252
is: Q6ZMU0
boundary condition: true

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_ee7497b4_0afe_4dbf_9b94_b5eedde751cd
has only substance units: false
has part: Q07326
is encoded by: hsa:84720
is encoded by: hsa:5281
is: SBO:0000297
boundary condition: true
has part: Q8TEQ8
name: PIGF:PIGO
initial concentration: NaN
constant: false
type: Species
initial amount: NaN

metaR EX gtp LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GTP exchange
type: Reaction

metaR FAOXC15NADPx
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid alpha oxidation(2-Hydroxyphytanoyl-CoA)(nadp)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_3b07d469_b480_4a63_975b_f04e0bd46f7a
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: ENPP1
is encoded by: hsa:5167
is: SBO:0000252
constant: false
is: P22413
has only substance units: false
type: Species

metaM lnlncgcoa r
has only substance units: false
is: HMDB06368
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: CHEBI:57363
constant: false
boundary condition: false
name: gamma-linolenoyl-CoA(4-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110024#_cd762b78_f17d_47f6_8b24_4a989cf93337
name: SLC43A1
type: Species
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:8501
is: O75387
is: SBO:0000252
initial concentration: NaN

metaR r0688
is described by: ECO:0000000
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110024#
is: SBO:0000176
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
type: Reaction
modifier: MODEL1310110024#
reactant: MODEL1310110024#
fast: false
reversible: true

metaM methf m
type: Species
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
is: CHEBI:57455
initial concentration: 1.0
boundary condition: false
name: (6R)-5,10-methenyltetrahydrofolate
is: HMDB01354
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_654e26e8_1f35_4be4_b51f_991445d08fec
has only substance units: false
boundary condition: true
is encoded by: hsa:4522
initial concentration: NaN
is: P11586
name: MTHFD1
constant: false
initial amount: NaN
is: SBO:0000252
type: Species

metaR EX cbasp LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-carbamoyl-L-aspartate
type: Reaction

metaM ksi pre22 g
is: HMDB00175
type: Species
is: C00130
is: CHEBI:58053
constant: false
is: SBO:0000247
notes: FORMULA: C185H297N13O150S6X CHARGE: -7
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 22

metaR r0233
fast: false
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
product: MODEL1310110024#
is: SBO:0000176
notes: GENE_ASSOCIATION: (875.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:10993714 NOTES:
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.22
name: UDPglucose:alpha-D-galactose-1-phosphate uridylyltransferase Galactose metabolism / Nucleotide sugars metabolism EC:2.7.7.12
modifier: MODEL1310110024#
type: Reaction

metaM arach c
name: arachidate
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB02212
initial amount: NaN
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
type: Species
constant: false
boundary condition: false
is: CHEBI:32360

http://identifiers.org/biomodels.db/MODEL1310110024#_c6b5c981_e352_4c7c_bc96_439f2ac585cf
constant: false
type: Species
boundary condition: true
is: SBO:0000252
name: _U52111_1_c
is encoded by: hsa:U52111
initial amount: NaN
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_24d61a96_28c8_4365_a11f_3e79d5f97e7d
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: PNP
type: Species
is encoded by: hsa:4860
has only substance units: false
initial concentration: NaN
is: P00491
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_31a1b765_ec8c_4108_974e_3a8c6b59e515
constant: false
is: SBO:0000297
is encoded by: hsa:54344
has part: O60762
type: Species
is encoded by: hsa:8813
name: DPM3:DPM1:DPM2
initial concentration: NaN
has part: O94777
boundary condition: true
initial amount: NaN
has part: Q86TM7
is encoded by: hsa:8818
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_6c979072_e2f5_4b8f_ba24_89b7054e86e8
is encoded by: hsa:6482
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: ST3GAL1
has only substance units: false
type: Species

metaM cs b l
initial amount: NaN
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), free chain
is: HMDB02183
boundary condition: false
is: CHEBI:36005
has only substance units: false
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110024#_bbd18afa_99f7_4666_b5c9_f9abadc99bcb
is: B4DK61
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: ACOX1
is encoded by: hsa:51
type: Species
has only substance units: false
constant: false
initial concentration: NaN

metaM odecrn c
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: octadecenoyl carnitine
constant: false
is: CHEBI:57394
is: SBO:0000247
type: Species
is: C00412
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/t23-/m0/s1
is: HMDB01114

metaR P4501B1r
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (1545.1) SUBSYSTEM: Steroid metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15579107,PMID:8910454 NOTES:_4 hydroxylation of 17 beta estradiol NJ
product: MODEL1310110024#
fast: false
reversible: false
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.14.14.1
kinetic law: MODEL1310110024#
name: cytochrome P450 1B1
is: SBO:0000176
type: Reaction
is described by: ECO:0000269

metaR EX ptdca LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentadecanoate exchange
type: Reaction

metaM pan4p e
boundary condition: false
notes: FORMULA: C11H21N2O7PS CHARGE: -2
is: CHEBI:47942
is: SBO:0000247
is: HMDB01416
is: C01134
initial concentration: 1.0
name: Pantetheine 4'-phosphate
type: Species
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_3de5983f_39fb_4586_873b_66b66527023c
name: SLC25A18
initial amount: NaN
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is: Q9H1K4
is: SBO:0000252
has only substance units: false
is encoded by: hsa:83733

http://identifiers.org/biomodels.db/MODEL1310110024#_7352cb79_48ce_4292_aacd_43405598d932
is: Q13630
name: TSTA3
type: Species
is encoded by: hsa:7264
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_2e7da35f_1299_4eab_bfa5_315569ea8aa6
constant: false
name: DGKG
is encoded by: hsa:1608
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
is: P49619
initial amount: NaN
boundary condition: true

metaM HC02204 e
is: CHEBI:27624
name: prostaglandin-b1
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110024#_8c9e0f18_3fce_40fc_b38c_36d6f2cce4f7
has only substance units: false
is encoded by: hsa:641371
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: E9KL42
constant: false
type: Species
initial amount: NaN
name: ACOT1

metaR UMPK4n
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110024#
type: Reaction
name: UMP kinase (GTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110024#
reversible: true
kinetic law: MODEL1310110024#
is described by: ECO:0000269
modifier: MODEL1310110024#

metaR r1728
is described by: ECO:0000000
product: MODEL1310110024#
name: Y+LAT2 Utilized transport
type: Reaction
reactant: MODEL1310110024#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110024#
fast: false
modifier: MODEL1310110024#

metaM malcoa c
name: Malonyl-CoA
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
is: HMDB01175
constant: false
initial concentration: 1.0
is: C00083
is: CHEBI:57384
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false

metaM ksii core4 pre7 g
has only substance units: false
is: HMDB00175
is: SBO:0000247
boundary condition: false
is: C00130
initial concentration: 1.0
notes: FORMULA: C75H121N6O56SX CHARGE: -2
name: keratan sulfate II biosynthesis, precursor 7
type: Species
constant: false
initial amount: NaN
is: CHEBI:58053

metaM ksi pre33 g
initial concentration: 1.0
has only substance units: false
is: CHEBI:58053
type: Species
is: C00130
is: HMDB00175
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C233H372N16O197S10X CHARGE: -11
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 33

http://identifiers.org/biomodels.db/MODEL1310110024#_736f6305_c6a0_405a_b10e_627c439aa95e
initial amount: NaN
boundary condition: true
name: ABCB4
is encoded by: hsa:5244
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_f557f8d7_554d_4c3d_b199_6e9f55fad035
type: Species
constant: false
name: ADO
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:84890
initial concentration: NaN
is: B3KXN9
has only substance units: false

metaM ser L m
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
name: L-serine
is: HMDB00187
is: CHEBI:17115
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0

metaM L2aadp m
is: CHEBI:58672
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB00510
boundary condition: false
is: SBO:0000247
type: Species
name: L-2-aminoadipate(1-)
has only substance units: false

metaR SMS
notes: GENE_ASSOCIATION: (259230.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14685263 NOTES:NJ
product: MODEL1310110024#
is: SBO:0000176
fast: false
name: Sphingomyelin synthase (homo sapiens)
type: Reaction
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.8.27
is described by: ECO:0000269
modifier: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_55c7bda2_31ae_43e3_8fe7_02eb2c7f051a
is encoded by: hsa:2639
has only substance units: false
initial amount: NaN
is: Q92947
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: GCDH

metaR EX dheas LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dehydroepiandrosterone sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_65d847a4_795b_402f_b638_2716dc798062
constant: false
name: PIGK
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
is: Q92643
is encoded by: hsa:10026
boundary condition: true
initial concentration: NaN

metaR EX psyltchol LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for psyllium-taurocholic acid complex
type: Reaction

metaR PRAGSr
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
is: SBO:0000176
name: phosphoribosylglycinamide synthase
product: MODEL1310110024#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110024#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.2.2

http://identifiers.org/biomodels.db/MODEL1310110024#_59dc5025_c7e5_4cae_9046_65bf44fab7ae
initial concentration: NaN
initial amount: NaN
name: ALDOA
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:226
constant: false

metaM HC02204 c
initial amount: NaN
name: prostaglandin-b1
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
is: CHEBI:27624
boundary condition: false
type: Species
has only substance units: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110024#_74e620a1_eaf4_425e_ad38_788cfb14ab28
initial concentration: NaN
has only substance units: false
name: CHKB
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:1120
is: Q9Y259

metaR EX biocyt LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biocytin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_6c9cb564_6c6e_4043_8c01_1fcadb9ef2f2
boundary condition: true
is encoded by: hsa:2805
is: P17174
type: Species
is: SBO:0000252
constant: false
has only substance units: false
name: GOT1
initial amount: NaN
initial concentration: NaN

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

metaR DIGALSIDEtl
kinetic law: MODEL1310110024#
is: SBO:0000185
reversible: true
name: digalside hs intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
type: Reaction
is described by: ECO:0000000
product: MODEL1310110024#
reactant: MODEL1310110024#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110024#_f1da28b7_fb71_4823_918c_765a383df66a
initial concentration: NaN
name: PIK3R1
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: B3KT19
has only substance units: false
is encoded by: hsa:5295
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_66b4931f_816d_4818_8994_5088d228f83c
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: Q6FGA0
is encoded by: hsa:9167
name: COX7A2L
is: SBO:0000252
constant: false
boundary condition: true
type: Species

metaR PTRCOX1
is version of: http://identifiers.org/ec-code/1.4.3.22
is version of: http://identifiers.org/ec-code/1.4.3.21
is: SBO:0000176
product: MODEL1310110024#
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (26.1) or (314.1) or (8639.1) or (314.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:9119395 NOTES:SAB
is described by: ECO:0000304
fast: false
kinetic law: MODEL1310110024#
reversible: false
type: Reaction
name: Putrescine:oxygen oxidoreductase (deaminating)
reactant: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_9c06fc87_5569_421c_a678_23e6c3f3eaae
is: P24539
boundary condition: true
initial concentration: NaN
name: ATP5F1
has only substance units: false
type: Species
constant: false
is encoded by: hsa:515
initial amount: NaN
is: SBO:0000252

metaM adpcoa x
initial concentration: 1.0
name: adipoylcoa
is: HMDB04047
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
is: C14143

metaM btn n
has only substance units: false
type: Species
is: CHEBI:57586
is: HMDB00030
name: biotinate
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120

metaR r0683
reactant: MODEL1310110024#
fast: false
type: Reaction
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: false
is: SBO:0000176
product: MODEL1310110024#
modifier: MODEL1310110024#
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3

metaM tchola e
initial amount: NaN
notes: FORMULA: C26H45NO7S CHARGE: 0
is: HMDB00036
initial concentration: 1.0
name: taurocholic acid
type: Species
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247

metaR TYROXDAc
reversible: false
kinetic law: MODEL1310110024#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.4.3.4
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.6 Confidence Level: 4 AUTHORS: PMID:11336106,PMID:14697899,PMID:8255365 NOTES:SAB also 1.4.3.4
product: MODEL1310110024#
is described by: ECO:0000269
name: Tyramine:oxygen oxidoreductase(deaminating)(flavin-containing) (cytosol)
reactant: MODEL1310110024#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110024#_adf6e99d_3b45_4487_8426_cf1c0a315a36
initial amount: NaN
is: SBO:0000252
name: PRPS1L1
type: Species
constant: false
has only substance units: false
is encoded by: hsa:221823
boundary condition: true
initial concentration: NaN
is: P21108

http://identifiers.org/biomodels.db/MODEL1310110024#_0edeb083_07ad_45be_aabf_5ca9681a8674
type: Species
constant: false
is encoded by: hsa:84889
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: SLC7A3
boundary condition: true
is: SBO:0000252
is: Q8WY07

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaM ppa e
is: SBO:0000247
initial concentration: 1.0
is: HMDB00237
has only substance units: false
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
boundary condition: false
initial amount: NaN
is: CHEBI:17272
name: propionate
constant: false
type: Species

metaR FACOAL170
modifier: MODEL1310110024#
reactant: MODEL1310110024#
product: MODEL1310110024#
name: fatty-acid--CoA ligase
type: Reaction
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
kinetic law: MODEL1310110024#
is described by: ECO:0000000
fast: false

metaM btn m
is: SBO:0000247
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB00030
name: biotinate
initial amount: NaN
is: CHEBI:57586
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_1e643b8f_c171_46fd_8424_96f1e49f1277
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
is: P35218
is: SBO:0000252
boundary condition: true
name: CA5A
is encoded by: hsa:763
type: Species

metaR NDPK7n
reactant: MODEL1310110024#
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110024#
fast: false
is: SBO:0000176
is described by: ECO:0000304
type: Reaction
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
reversible: true
product: MODEL1310110024#

metaM octe5coa m
boundary condition: false
constant: false
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
name: 5-octenoylcoa
has only substance units: false
type: Species
is: http://identifiers.org/pubchem.compound/16019966
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110024#_ff21ed03_bb3a_43df_b081_05e131491ef1
has only substance units: false
initial concentration: NaN
is encoded by: hsa:8760
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
name: CDS2
is: O95674
boundary condition: true

metaR r0686
is version of: http://identifiers.org/ec-code/2.3.2.2
product: MODEL1310110024#
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
is: SBO:0000176
fast: false
reversible: true
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110024#_81e3f343_bd09_48e5_9e27_782a6c2d21ac
has only substance units: false
is encoded by: hsa:AV727634
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
name: _AV727634_1_c
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_4ca46f21_2e2a_4a97_ba68_4d998d258bf7
has only substance units: false
is encoded by: hsa:23428
constant: false
initial amount: NaN
name: SLC7A8:SLC3A2
type: Species
initial concentration: NaN
has part: Q86U05
boundary condition: true
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110024#_54204289_b159_44b4_8243_36f5b9d398fd
constant: false
is: SBO:0000252
type: Species
name: CPT1B
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1375
is: Q53FV7
boundary condition: true
has only substance units: false

metaR URIt5le
product: MODEL1310110024#
type: Reaction
is described by: ECO:0000134
modifier: MODEL1310110024#
fast: false
is: SBO:0000185
reversible: false
name: uridine transport in via sodium symport (1:2)
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#

metaR R group phosphotase 1
is described by: ECO:0000000
kinetic law: MODEL1310110024#
fast: false
type: Reaction
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110024#
name: R group phosphotase 1
is: SBO:0000176
reversible: false

metaR STRDNCt
is: SBO:0000185
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110024#
fast: false
is described by: ECO:0000000
reversible: true
name: fatty acid transport via diffusion
type: Reaction
kinetic law: MODEL1310110024#

metaM c12dccoa c
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
constant: false
initial amount: NaN
has only substance units: false
type: Species
name: dodecanedioylcoa
is: SBO:0000247
is: HMDB00623

metaR NADtx
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
name: transport of NAD into peroxisome
reversible: true
type: Reaction
product: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000185
reactant: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_a8473a1b_d901_4447_a3e4_10008976d089
is: P48728
constant: false
is: SBO:0000252
is encoded by: hsa:275
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
name: AMT
has only substance units: false

metaM zymstnl r
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB06841
has only substance units: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
boundary condition: false
type: Species
constant: false
is: CHEBI:16608
name: 5alpha-cholest-8-en-3beta-ol

http://identifiers.org/biomodels.db/MODEL1310110024#_5b1658ad_f48e_4485_b69f_30afa38fad7b
is: P83881
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:6173
name: RPL36A

metaR RE2660N
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
product: MODEL1310110024#
kinetic law: MODEL1310110024#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.96
reactant: MODEL1310110024#
modifier: MODEL1310110024#
name: RE2660
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction

metaM lnlncgcoa m
is: CHEBI:57363
is: HMDB06368
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: gamma-linolenoyl-CoA(4-)
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
type: Species

metaM arach e
is: SBO:0000247
name: arachidate
initial amount: NaN
type: Species
has only substance units: false
is: HMDB02212
constant: false
initial concentration: 1.0
is: CHEBI:32360
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110024#_13b80c30_f10a_4907_8bdd_bdb52d80a0a1
boundary condition: true
initial concentration: NaN
is: O95498
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: VNN2
constant: false
is encoded by: hsa:8875
type: Species

metaR NAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB
reversible: true
type: Reaction
product: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: sodium transport via diffusion (perioxisome)
reactant: MODEL1310110024#

metaR THD1m
type: Reaction
notes: GENE_ASSOCIATION: (23530.2) or (23530.1) SUBSYSTEM: NAD metabolism EC Number: 1.6.1.2 Confidence Level: 4 AUTHORS: PMID:12223207,PMID:8647343,PMID:9524818 NOTES:TDV (2-6-2003)
is version of: http://identifiers.org/ec-code/1.6.1.2
kinetic law: MODEL1310110024#
name: NAD(P) transhydrogenase
modifier: MODEL1310110024#
product: MODEL1310110024#
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_d26a7569_eaab_4174_8051_8cf7fe32de82
is: P46459
constant: false
type: Species
is encoded by: hsa:4905
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: NSF
initial amount: NaN
has only substance units: false

metaM pan4p c
initial amount: NaN
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
initial concentration: 1.0
is: CHEBI:47942
is: SBO:0000247
is: HMDB01416
name: Pantetheine 4'-phosphate
has only substance units: false
is: C01134
boundary condition: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_3148d18c_b1b2_411e_8266_bc0894e1d8c0
name: GLA
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:2717
is: Q53Y83
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_874e2d63_3ed1_42b7_995b_065defcb3c7b
is: Q9NRD8
initial amount: NaN
is encoded by: hsa:50506
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
name: DUOX2
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110024#_bf8c4904_cd89_46ba_8a73_1d16ffde982e
boundary condition: true
constant: false
is encoded by: hsa:2108
name: ETFA
is: P13804
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252

metaM dhcholestancoa x
is: SBO:0000247
is: CHEBI:15494
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
is: HMDB02159
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
type: Species

metaR A4GALTg
modifier: MODEL1310110024#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.228
reactant: MODEL1310110024#
is: SBO:0000176
reversible: false
name: Lactosylceramide 4-alpha-galactosyltransferase
notes: GENE_ASSOCIATION: (53947.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.228 Confidence Level: 4 AUTHORS: PMID:10747952,PMID:10748143 NOTES:EC: 2.4.1.228 NJ
product: MODEL1310110024#
fast: false
type: Reaction
kinetic law: MODEL1310110024#

metaM CE1944 c
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
name: 1-pyrrolinium
is: CHEBI:36781
has only substance units: false
boundary condition: false
notes: FORMULA: C4H8N CHARGE: 1 INCHI: InChI=1S/C4H7N/c1-2-4-5-3-1/h3H,1-2,4H2/p+1 EHMN_ABBREVIATION: CE1944

metaM octe5coa x
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/16019966
has only substance units: false
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
initial amount: NaN
name: 5-octenoylcoa
constant: false
type: Species
boundary condition: false

metaM HC01496 m
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
is: CHEBI:28095
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
name: 2-Amino-3-oxoadipate
type: Species

metaM acnam c
initial concentration: 1.0
has only substance units: false
is: HMDB00230
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:35418
type: Species
name: N-acetylneuraminate
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270

metaM Lcystin e
type: Species
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
initial amount: NaN
is: CHEBI:16283
has only substance units: false
initial concentration: 1.0
name: L-cystine
boundary condition: false
constant: false
is: HMDB00192
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110024#_fe038d49_3ad3_494b_ba2a_52f11233d4ed
is: SBO:0000252
is: Q9NRX3
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:56901
has only substance units: false
name: NDUFA4L2
initial amount: NaN
type: Species

metaM prostgd2 c
name: prostaglandin D2(1-)
type: Species
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
has only substance units: false
initial concentration: 1.0
is: CHEBI:57406
is: SBO:0000247
boundary condition: false
is: HMDB01403
initial amount: NaN

metaM dhcholestanate x
initial amount: NaN
has only substance units: false
is: HMDB00359
boundary condition: false
is: CHEBI:16577
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
constant: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate

metaM HC02216 e
constant: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
is: CHEBI:28922
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: prostaglandin-f2beta
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_1cbfbd31_6de5_46dc_89ea_399e7a0d46c8
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: SLC7A5
is encoded by: hsa:8140
constant: false
is: Q8IV97
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_3379253f_da9b_4fac_8c89_a70fd88db320
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
name: MAT2A
type: Species
is: P31153
is encoded by: hsa:4144
initial amount: NaN

metaM retinal c
constant: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:15035
is: HMDB01358
is: SBO:0000247
initial concentration: 1.0
name: retinal

metaR H2O2syn
is version of: http://identifiers.org/ec-code/1.6.3.1
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (53905.1) or (50506.1) or (53905.2) SUBSYSTEM: Tyrosine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15677770,PMID:15972824 NOTES:SAB lumped reaction--first O2 goes to superoxide radical, then dismutes to H2O2
product: MODEL1310110024#
fast: false
kinetic law: MODEL1310110024#
type: Reaction
reversible: false
reactant: MODEL1310110024#
name: Hydrogen peroxide synthesis (NADPH dependent)
is: SBO:0000176
is described by: ECO:0000304

metaM ksi pre6 g
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 6
notes: FORMULA: C107H174N7O80SX CHARGE: -2
constant: false
is: C00130
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB00175
is: SBO:0000247
is: CHEBI:58053

metaM 4mlacac c
is: HMDB02052
boundary condition: false
is: CHEBI:17105
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1- HEPATONET_1.0_ABBREVIATION: HC00635 EHMN_ABBREVIATION: C01036
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: 4-maleylacetoacetate
initial amount: NaN
constant: false

metaM dttp e
boundary condition: false
is: HMDB01342
initial amount: NaN
has only substance units: false
name: dTTP(4-)
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: CHEBI:37568
type: Species

metaR L LACt2r
fast: false
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
type: Reaction
is: SBO:0000185
name: L-lactate reversible transport via proton symport
product: MODEL1310110024#
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110024#

metaM cs e deg4 l
is: SBO:0000247
type: Species
notes: FORMULA: C31H46NO38S4 CHARGE: -5
initial concentration: 1.0
initial amount: NaN
is: HMDB00127
is: CHEBI:15748
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 4
boundary condition: false
constant: false
has only substance units: false

metaR DDPGAm
is described by: ECO:0000000
product: MODEL1310110024#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.2.14 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:14193832,PMID:15849464,PMID:9783918 NOTES:IT rxn is done by 4.1.2.14 and 4.1.3.16 mitochondrial isozyme - NCD
reactant: MODEL1310110024#
name: 2-dehydro-3-deoxy-phosphogluconate aldolase, mitochondrial
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110024#

metaM L2aadp c
boundary condition: false
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
is: HMDB00510
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:58672
name: L-2-aminoadipate(1-)
type: Species
has only substance units: false

metaR AKR1C1
modifier: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: (1645.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.1.20 Confidence Level: 4 AUTHORS: PMID:8486699 NOTES:NJ
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.3.1.20
name: aldo-keto reductase family 1, member C1 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110024#
reversible: false
type: Reaction
product: MODEL1310110024#

metaM lnlccoa m
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
is: HMDB01064
is: SBO:0000247
name: linoleic coenzyme A
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/5462164
type: Species
initial amount: NaN
constant: false
has only substance units: false

metaM Sfglutth c
initial amount: NaN
constant: false
name: S-formylglutathionate(1-)
is: HMDB01550
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:57688
boundary condition: false
initial concentration: 1.0

metaM methf c
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB01354
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
is: C00445
is: CHEBI:57455
name: 5,10-Methenyltetrahydrofolate
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_a1b14744_9377_41c8_a031_a25281cf6fea
name: FOLR1
is encoded by: hsa:2348
initial concentration: NaN
type: Species
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_701bf00b_ef40_489d_9837_85b95a153f8b
type: Species
is encoded by: hsa:6342
boundary condition: true
has only substance units: false
is: C9JC79
initial amount: NaN
name: SCP2
initial concentration: NaN
is: SBO:0000252
constant: false

metaM HC02216 c
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
boundary condition: false
is: SBO:0000247
type: Species
name: prostaglandin-f2beta
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:28922

metaM cysam c
type: Species
name: cysteaminium
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:58029
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678
boundary condition: false
is: HMDB02991
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110024#_a61c2c1c_7205_4fe2_adc6_b695e15b674c
initial amount: NaN
type: Species
boundary condition: true
name: DHCR24
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1718
constant: false
is: Q15392

http://identifiers.org/biomodels.db/MODEL1310110024#_356b4dd5_c166_42d5_9454_898c023fca62
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: Q9Y5B8
name: NME7
has only substance units: false
is encoded by: hsa:29922
type: Species
constant: false
is: SBO:0000252

metaR PIPLCn
is version of: http://identifiers.org/ec-code/3.1.4.11
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110024#
reversible: false
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD
name: phosphatidylinositol phospholipase C, nucleus
modifier: MODEL1310110024#
reactant: MODEL1310110024#
type: Reaction
product: MODEL1310110024#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110024#_fa7c138b_4561_476a_b360_d85357e41b8f
initial concentration: NaN
boundary condition: true
is: P07195
name: LDHB
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:3945
initial amount: NaN
type: Species

metaR EX aicar LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
type: Reaction

metaM ppa c
is: HMDB00237
is: CHEBI:17272
has only substance units: false
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
is: SBO:0000247
initial amount: NaN
constant: false
name: propionate
type: Species
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110024#_4610a3e4_adc2_4e60_8b3e_36e36a9c65dc
constant: false
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:83715
name: ESPN
has only substance units: false
is: B1AK53

metaM man6p c
type: Species
is: HMDB01078
initial amount: NaN
name: D-Mannose 6-phosphate
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
is: CHEBI:17369

metaM dgchol e
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
initial concentration: 1.0
name: glycochenodeoxycholate
has only substance units: false
constant: false
is: CHEBI:36252
type: Species
initial amount: NaN
boundary condition: false
is: HMDB00637
is: SBO:0000247

metaR 3DSPHR
modifier: MODEL1310110024#
reversible: false
reactant: MODEL1310110024#
name: 3-Dehydrosphinganine reductase
is version of: http://identifiers.org/ec-code/1.1.1.102
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (2531.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 1.1.1.102 Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
fast: false
kinetic law: MODEL1310110024#

metaM dttp c
is: C00459
is: HMDB01342
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:37568
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
name: dTTP

http://identifiers.org/biomodels.db/MODEL1310110024#_9113de45_1d47_44b9_bdeb_f129993eae13
constant: false
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:50
is: Q99798
name: ACO2
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_08cebb58_8735_4f92_b302_b24ba9f8c31c
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:4694
is: SBO:0000252
initial concentration: NaN
type: Species
name: NDUFA1
is: Q6IBB5
constant: false

metaM tchola c
is: HMDB00036
is: CHEBI:36257
initial amount: NaN
boundary condition: false
name: taurocholic acid
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
has only substance units: false

metaR GLUNm
kinetic law: MODEL1310110024#
type: Reaction
reactant: MODEL1310110024#
product: MODEL1310110024#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.2
name: glutaminase (mitochondrial)
notes: GENE_ASSOCIATION: (2744.1) or (27165.2) or (27165.1) SUBSYSTEM: Glutamate metabolism EC Number: 3.5.1.2 Confidence Level: 4 AUTHORS: PMID:10719215,PMID:12579526 NOTES:
reversible: false
fast: false
is described by: ECO:0000269
modifier: MODEL1310110024#

metaR FACOAL226
is: SBO:0000176
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
fast: false
type: Reaction
modifier: MODEL1310110024#
name: fatty-acid--CoA ligase
is described by: ECO:0000000
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110024#_075c80f2_db78_4795_81a4_3aea27f8454e
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: QDPR
is encoded by: hsa:5860
has only substance units: false
constant: false
is: P09417

metaR PIt8
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
reversible: true
reactant: MODEL1310110024#
modifier: MODEL1310110024#
is described by: ECO:0000006
is: SBO:0000185
type: Reaction
name: phosphate transport in/out via Na+ symporter
fast: false
product: MODEL1310110024#
kinetic law: MODEL1310110024#

metaR NDP7g
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.6
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110024#
name: nucleoside-diphosphatase (UDP), Golgi apparatus
product: MODEL1310110024#
reversible: false
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD
fast: false

metaR SUCCt4 2
fast: false
kinetic law: MODEL1310110024#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
type: Reaction
product: MODEL1310110024#
modifier: MODEL1310110024#
name: succinate transport via sodium symport
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110024#

metaM thym e
is: HMDB00262
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: thymine
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:17821
notes: FORMULA: C5H6N2O2 CHARGE: 0 INCHI: InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
type: Species

metaR HSAT2ly
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
name: heparan-glucosaminide N-acetyltransferase, lysosomal
type: Reaction
reversible: false
kinetic law: MODEL1310110024#
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_2797d353_69cb_4612_b9cf_dd56cb57f72a
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3417
is: O75874
is: SBO:0000252
constant: false
boundary condition: true
name: IDH1

metaM m4mpdol L c
initial amount: NaN
boundary condition: false
has only substance units: false
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
notes: FORMULA: C1540H2528N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:37633
constant: false
type: Species

metaR r0797
is described by: ECO:0000000
reversible: true
name: glycine N-choloyltransferase EC:2.3.1.65
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
reactant: MODEL1310110024#
fast: false
type: Reaction
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
kinetic law: MODEL1310110024#
product: MODEL1310110024#

metaM hmgcoa c
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:15467
has only substance units: false
is: HMDB01375
constant: false
name: Hydroxymethylglutaryl-CoA
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110024#_36bd3b34_9930_476a_a68b_0311c53164c9
is: P42336
is encoded by: hsa:5290
name: PIK3CA
type: Species
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR DASPO1p
reversible: false
type: Reaction
is: SBO:0000176
name: D-aspartate oxidase, peroxisomal
is version of: http://identifiers.org/ec-code/1.4.3.1
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (8528.2) or (8528.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 1.4.3.1 Confidence Level: 4 AUTHORS: PMID:12209855,PMID:9820813 NOTES:MM
product: MODEL1310110024#
modifier: MODEL1310110024#
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110024#_6fc59c2c_f83a_4341_8a9c_f4eba36196e7
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:761
type: Species
name: CA3
is: SBO:0000252
is: P07451

metaM dhcholestancoa r
constant: false
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
is: SBO:0000247
is: CHEBI:15494
has only substance units: false
type: Species
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
initial amount: NaN
is: HMDB02159
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110024#_1cbc4151_f9a8_4be0_9e04_bed69ee3e7b2
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:BC005314
constant: false
name: _BC005314_1_x
is: SBO:0000252
boundary condition: true
type: Species

metaM dgchol c
constant: false
is: CHEBI:36252
type: Species
is: SBO:0000247
has only substance units: false
name: glycochenodeoxycholate
initial amount: NaN
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
boundary condition: false
is: HMDB00637
initial concentration: 1.0

metaR PIt7
product: MODEL1310110024#
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
fast: false
reactant: MODEL1310110024#
is described by: ECO:0000269
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
is: SBO:0000185
name: phosphate transport in/out via three Na+ symporter

http://identifiers.org/biomodels.db/MODEL1310110024#_15c007c7_ab0c_4394_a27d_2e34b4c8941d
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: P19801
name: ABP1
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:26
type: Species

metaR ASAH1
reversible: false
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (427.1) or (427.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.5.1.23 Confidence Level: 4 AUTHORS: PMID:8955159 NOTES:NJ
modifier: MODEL1310110024#
name: N-acylsphingosine amidohydrolase
is version of: http://identifiers.org/ec-code/3.5.1.23
is described by: ECO:0000000
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#

metaR EX hdcea LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecenoate (n-C16:1)
type: Reaction

metaM ttdcrn c
boundary condition: false
notes: FORMULA: C21H41NO4 CHARGE: 0 INCHI: InChI=1/C21H41NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-21(25)26-19(17-20(23)24)18-22(2,3)4/h19H,5-18H2,1-4H3/t19-/m1/s1
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3413344
type: Species
is: SBO:0000247
constant: false
name: tetradecanoyl carnitine
is: HMDB05066
has only substance units: false

metaR r0796
product: MODEL1310110024#
modifier: MODEL1310110024#
is: SBO:0000176
reactant: MODEL1310110024#
fast: false
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
reversible: true
type: Reaction
is described by: ECO:0000000
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
is version of: http://identifiers.org/ec-code/1.2.1.5

metaM 3hbcoa m
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:57316
is: SBO:0000247
name: (S)-3-hydroxybutanoyl-CoA(4-)
is: HMDB01166

metaR NACHEX25ly
product: MODEL1310110024#
kinetic law: MODEL1310110024#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
modifier: MODEL1310110024#
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
fast: false

metaR S23T3g
product: MODEL1310110024#
reversible: false
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (6487.4) or (6487.9) or (6487.11) or (6487.6) or (6487.7) or (6487.10) or (6487.5) or (6487.1) or (6487.2) or (6487.8) or (6487.3) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.6 Confidence Level: 4 AUTHORS: PMID:8333853 NOTES:NCD
reactant: MODEL1310110024#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.4.99.6
type: Reaction
name: beta-galactoside alpha-2,3-sialyltransferase (complex N-glycan)
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110024#_62c65d13_2283_406b_b7d6_c9cbb237fd1a
name: CYB5D1
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:124637
boundary condition: true
is: Q6P9G0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_a508d5e5_6c5e_4444_85b8_a10d8d7fc60a
is encoded by: hsa:3658
is: SBO:0000252
initial concentration: NaN
is: P48200
type: Species
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
name: IREB2

metaM thym c
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:17821
is: C00178
is: HMDB00262
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
name: Thymine

metaM Lcystin c
is: HMDB00192
constant: false
initial concentration: 1.0
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:16283
name: L-cystine
is: SBO:0000247

metaR FACOAL224
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
modifier: MODEL1310110024#
reversible: true
is: SBO:0000176
type: Reaction
reactant: MODEL1310110024#
product: MODEL1310110024#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110024#_1f436608_d825_4467_9274_41415b77f91b
boundary condition: true
type: Species
has part: Q6NZ59
initial amount: NaN
has only substance units: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
is: SBO:0000297
initial concentration: NaN
is encoded by: hsa:522
constant: false

metaR r1619
fast: false
product: MODEL1310110024#
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110024#
is: SBO:0000185
reactant: MODEL1310110024#
type: Reaction
kinetic law: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_509c890c_69fb_47da_ab66_7860d1e0fef0
constant: false
boundary condition: true
is encoded by: hsa:5313
is: P30613
initial amount: NaN
name: PKLR
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species

metaM dhcholestanate r
initial concentration: 1.0
constant: false
is: HMDB00359
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
is: CHEBI:16577
has only substance units: false
initial amount: NaN
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
boundary condition: false
type: Species
is: SBO:0000247

metaR r0084
modifier: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
reactant: MODEL1310110024#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.1.1.42
is: SBO:0000176
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
product: MODEL1310110024#
reversible: true

metaR MELATNOX
reactant: MODEL1310110024#
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.14.13.48
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.14.1
is described by: ECO:0000269
name: Melatonin:NADP oxidoreductase
is: SBO:0000176
fast: false
reversible: false
notes: GENE_ASSOCIATION: (1557.1) or (1543.1) or (1545.1) or (1544.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15616152 NOTES:SAB made up name

metaM prostgd2 e
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: CHEBI:57406
name: prostaglandin D2(1-)
has only substance units: false
is: HMDB01403
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_aef8de24_e16e_478d_94d8_267f973dadc3
initial concentration: NaN
is encoded by: hsa:517
is encoded by: hsa:9551
constant: false
is: SBO:0000297
type: Species
has only substance units: false
initial amount: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2
boundary condition: true
has part: F8W7V3

http://identifiers.org/biomodels.db/MODEL1310110024#_001b2af6_995e_462b_bbc6_c4854b948a9e
initial amount: NaN
is encoded by: hsa:8395
boundary condition: true
constant: false
is: SBO:0000252
name: PIP5K1B
type: Species
has only substance units: false
is: O14986
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_4d3797c1_4459_4de2_bee6_92c3a35dc5af
name: ACSS2
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
is: Q5QPH3
is encoded by: hsa:55902
initial concentration: NaN
constant: false
initial amount: NaN

metaR r0083
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
product: MODEL1310110024#
type: Reaction
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.42
reactant: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_e0e8d645_38ac_4683_8900_f92b353d9f2b
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:AI971036
name: _AI971036_1_c
initial concentration: NaN
boundary condition: true

metaR PROSTGE2t2
product: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false
reversible: true
modifier: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
reactant: MODEL1310110024#
is: SBO:0000185
is described by: ECO:0000269
name: prostaglandin uniport

metaR 4HBZCOAFm
reversible: false
kinetic law: MODEL1310110024#
name: 4-hydroxybenzoyl-CoA formation
product: MODEL1310110024#
fast: false
type: Reaction
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110024#_6b62dd91_8fc2_4ada_84ce_f59fb4d38044
has part: P23378
constant: false
is: SBO:0000297
is encoded by: hsa:275
initial concentration: NaN
is encoded by: hsa:2731
has part: P23434
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
has part: P48728
is encoded by: hsa:2653
name: DLD:GCSH:GLDC:AMT

http://identifiers.org/biomodels.db/MODEL1310110024#_6214e582_8192_4662_b507_90e3fdb00703
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
constant: false
name: _642502_1_c
is encoded by: hsa:642502
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_dec31ccf_450e_40e8_8d0e_e24c4c0105c7
name: TDO2
initial concentration: NaN
is: P48775
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:6999
is: SBO:0000252

metaM nicrns c
name: Nicotinate D-ribonucleoside
boundary condition: false
constant: false
notes: FORMULA: C11H13NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01628 EHMN_ABBREVIATION: C05841
is: HMDB06809
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:58527

metaR r0085
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
reactant: MODEL1310110024#
is: SBO:0000176
modifier: MODEL1310110024#
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.42
reversible: false
kinetic law: MODEL1310110024#
is described by: ECO:0000000
type: Reaction

metaM sph1p c
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB01383
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
is: CHEBI:57939
type: Species
initial amount: NaN

metaR PIACGT
type: Reaction
fast: false
reversible: false
kinetic law: MODEL1310110024#
is described by: ECO:0000000
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.4.1.83
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (5279.1) and (51227.2) and (5283.1) and (5277.2) and (9091.1) and (8818.1) or (5279.1) and (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) or (51227.1) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.2) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (5279.2) and (8818.1) or (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.1) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.2) or (51227.1) and (5277.1) and (5283.1) and (9091.1) and (5279.2) and (8818.1) or (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (9091.2) and (5277.3) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (8818.2) and (5279.2) or (5279.1) and (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.2) or (51227.1) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.2) and (9091.2) and (5277.1) and (5283.1) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.2) and (5283.1) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (5283.1) and (5277.2) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (5283.1) and (5277.2) and (9091.1) and (8818.2) or (51227.3) and (9091.2) and (5283.1) and (5277.2) and (5279.2) and (8818.1) or (5279.1) and (51227.3) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (51227.1) and (9091.2) and (5277…
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.4.1.198
is: SBO:0000176
name: phosphatidylinositol N-acetylglucosaminyltransferase

metaR C10DCe
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of sebacoyl carnitine into extra cellular space
type: Reaction

metaR r1785
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: false
product: MODEL1310110024#
is: SBO:0000185
reactant: MODEL1310110024#
fast: false

metaM no e
name: Nitric oxide
is: SBO:0000247
is: HMDB03378
constant: false
is: CHEBI:16480
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
initial amount: NaN
is: C00533
has only substance units: false

metaR ENGASE3ly
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110024#
fast: false
reactant: MODEL1310110024#
product: MODEL1310110024#
name: endo-beta-N-acetylglucosaminidase, lysosomal
type: Reaction

metaR FATP3t
kinetic law: MODEL1310110024#
type: Reaction
name: fatty acid electroneutral transport
product: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
modifier: MODEL1310110024#
is described by: ECO:0000269
is: SBO:0000185
reversible: true
fast: false

metaM dcsptn1 c
is: HMDB13123
name: docosa-4,7,10,13,16-pentaenoic acid
constant: false
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5282848
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR ACP1 FMN
type: Reaction
reactant: MODEL1310110024#
is described by: ECO:0000254
product: MODEL1310110024#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.2
name: acid phosphatase (FMN)
fast: false
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (52.1) or (52.3) or (52.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:8522318 NOTES:INVALID ECO TERM: IFH

metaR r1618
is described by: ECO:0000000
product: MODEL1310110024#
modifier: MODEL1310110024#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110024#
is: SBO:0000185
kinetic law: MODEL1310110024#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR r1050
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
product: MODEL1310110024#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false
name: Vesicular transport
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110024#_ef1a20a0_d89c_4ac0_852c_247e5fc7ce86
boundary condition: true
type: Species
is encoded by: hsa:570
constant: false
initial amount: NaN
name: BAAT
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: Q14032

metaR LEUt4
type: Reaction
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (81539.1) or (84889.1) or (6520.1) or (6542.1) or (6541.1) or (11254.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10391915,PMID:10891391,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:1376926,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
reversible: false
modifier: MODEL1310110024#
product: MODEL1310110024#
is: SBO:0000185
fast: false
reactant: MODEL1310110024#
name: L-leucine transport in via sodium symport
is described by: ECO:0000269

metaR r2132
fast: false
modifier: MODEL1310110024#
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110024#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110024#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110024#

metaR EX leuktrE4 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene E4 exchange
type: Reaction

metaR r0086
is: SBO:0000176
modifier: MODEL1310110024#
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
reactant: MODEL1310110024#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.3
fast: false
reversible: false
kinetic law: MODEL1310110024#

metaM dcmp c
is: SBO:0000247
type: Species
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
is: HMDB01202
initial amount: NaN
has only substance units: false
name: dCMP
is: CHEBI:57566
initial concentration: 1.0
boundary condition: false
is: C00239
constant: false

metaR ORNt4m
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
reversible: true
reactant: MODEL1310110024#
name: ornithine mitochondrial transport exchange with citruline
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
is: SBO:0000185
fast: false
product: MODEL1310110024#
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_138a26ab_c44d_4f9f_9721_ba383bc36695
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
name: ALPP
is: P05187
is encoded by: hsa:250
initial concentration: NaN

metaR r1784
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110024#
type: Reaction
kinetic law: MODEL1310110024#
fast: false
modifier: MODEL1310110024#
reversible: false
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_4751a27e_84e3_48d8_b605_fe48f22d2274
initial concentration: NaN
is encoded by: hsa:4719
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
is: P28331
constant: false
name: NDUFS1

http://identifiers.org/biomodels.db/MODEL1310110024#_3e53e9dc_5294_4e98_a395_3de94cc196df
initial concentration: NaN
initial amount: NaN
name: SLC16A2
type: Species
constant: false
is: P36021
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:6567

http://identifiers.org/biomodels.db/MODEL1310110024#_a466d900_f268_4b11_bbcc_771a182c7545
is: O00142
boundary condition: true
constant: false
has only substance units: false
type: Species
is encoded by: hsa:7084
initial concentration: NaN
initial amount: NaN
name: TK2
is: SBO:0000252

metaR r0913
fast: false
product: MODEL1310110024#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110024#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction

metaR r1617
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110024#
is: SBO:0000185
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110024#

metaM eitetcoa m
initial amount: NaN
type: Species
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892790
constant: false
is: SBO:0000247
has only substance units: false
name: 5,8,11,14-eicosatetraenoylcoa
boundary condition: false
initial concentration: 1.0

metaR r2133
product: MODEL1310110024#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
type: Reaction
reactant: MODEL1310110024#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is: SBO:0000185

metaR PAFt
is described by: ECO:0000000
name: 1-alkyl 2-acteylglycerol 3-phosphocholine transport
product: MODEL1310110024#
type: Reaction
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
reversible: true
reactant: MODEL1310110024#
is: SBO:0000185

metaR AG13T11g
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110024#
product: MODEL1310110024#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
fast: false
type: Reaction
is: SBO:0000176

metaM dodecanac x
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
name: Dodecanedioic acid
type: Species
notes: FORMULA: C12H20O4 CHARGE: -2
is: HMDB00623
initial concentration: 1.0

metaM lnlccoa c
constant: false
initial amount: NaN
name: linoleic coenzyme A
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5462164
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB01064
boundary condition: false

metaM sph1p e
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
boundary condition: false
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:57939
is: HMDB01383

metaR EX ala D LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Alanine exchange
type: Reaction

metaM cs b deg2 l
initial concentration: 1.0
notes: FORMULA: C37H54NO41S3 CHARGE: -5
has only substance units: false
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 2
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:57455
is: HMDB01354
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110024#_2635dc09_6ac4_46d6_870b_af82c9a86171
constant: false
initial concentration: NaN
has only substance units: false
is: Q9H999
boundary condition: true
type: Species
name: PANK3
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:79646

metaM dcsptn1 e
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5282848
has only substance units: false
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
name: docosa-4,7,10,13,16-pentaenoic acid
constant: false
is: HMDB13123

metaR S6TASE24ly
name: N-acetylglucosamine-6-sulfatase, lysosomal
fast: false
is: SBO:0000176
reversible: true
is described by: ECO:0000000
product: MODEL1310110024#
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
type: Reaction
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.14

metaR AMPtp
name: AMP transporter, peroxisome
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110024#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ
kinetic law: MODEL1310110024#
product: MODEL1310110024#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_fc7504d9_f509_4ed2_b88c_6292a196a1fd
name: PCBD1
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5092
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR r2130
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110024#
reactant: MODEL1310110024#
fast: false
type: Reaction
is: SBO:0000185
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#

metaM no c
boundary condition: false
is: C00533
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
name: Nitric oxide
is: HMDB03378
is: CHEBI:16480
is: SBO:0000247

metaR G14T14g
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
is described by: ECO:0000000
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false
type: Reaction
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false

http://identifiers.org/biomodels.db/MODEL1310110024#_ada9d975_4894_40d6_88e9_6994af725a51
has only substance units: false
constant: false
is: Q9Y2D0
is encoded by: hsa:11238
initial amount: NaN
type: Species
name: CA5B
is: SBO:0000252
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110024#_06b57c7a_8856_4ea4_8891_4a7f8f70ed7c
type: Species
name: DGKB
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:1607
initial concentration: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110024#_fadcb20d_3d79_4446_8170_31abcb71d248
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:4697
is: O00483
initial amount: NaN
name: NDUFA4
initial concentration: NaN
boundary condition: true
constant: false

metaR r1616
product: MODEL1310110024#
modifier: MODEL1310110024#
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110024#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110024#
is: SBO:0000185

metaR EX vacc LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: vaccenic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_bb430e5b_e046_427a_91b0_a9348c337d5f
type: Species
name: NUDT12
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: Q9BQG2
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:83594

metaM lac L c
constant: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
is: HMDB00190
initial concentration: 1.0
is: CHEBI:16651
initial amount: NaN
name: (S)-lactate
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false

metaR GGT6
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
product: MODEL1310110024#
is: SBO:0000176
name: Gamma-glutamyltransferase
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
reversible: true
type: Reaction

metaR r0911
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110024#
reversible: true
reactant: MODEL1310110024#
name: Facilitated diffusion
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110024#

metaR GluForTx
is version of: http://identifiers.org/ec-code/2.1.2.5
is described by: ECO:0000269
reversible: false
fast: false
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Histidine metabolism EC Number: 2.1.2.5 Confidence Level: 4 AUTHORS: PMID:12815595 NOTES:SAB
kinetic law: MODEL1310110024#
is: SBO:0000176
name: Glutamate formimidoyltransferase
product: MODEL1310110024#
type: Reaction
reactant: MODEL1310110024#
modifier: MODEL1310110024#

metaR EX strch2 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})
type: Reaction

metaM pram c
name: 5-Phospho-beta-D-ribosylamine
notes: FORMULA: C5H11NO7P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01053 EHMN_ABBREVIATION: C03090
boundary condition: false
is: CHEBI:58681
constant: false
type: Species
has only substance units: false
is: HMDB01128
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: C03090

http://identifiers.org/biomodels.db/MODEL1310110024#_e66bbd03_041c_4bb5_9fd1_e4881d76f2a0
is: SBO:0000252
constant: false
name: DDO
boundary condition: true
is encoded by: hsa:8528
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_7bc617df_7e89_4be2_8ff1_b2354b625938
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: PIK3C2B
is: O00750
is encoded by: hsa:5287
boundary condition: true
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_b2f57481_66d4_42a2_ad91_2759f3808ad9
is: Q8TBF5
is: SBO:0000252
name: PIGX
type: Species
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:54965
boundary condition: true
initial concentration: NaN

metaR r2131
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110024#
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reactant: MODEL1310110024#
fast: false
is described by: ECO:0000000

metaR r1615
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110024#
is: SBO:0000185
type: Reaction
product: MODEL1310110024#

metaM hmgcoa m
is: HMDB01375
name: Hydroxymethylglutaryl-CoA
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:15467
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species

metaR r1051
is: SBO:0000185
product: MODEL1310110024#
reactant: MODEL1310110024#
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
name: Vesicular transport

metaR LNELDCCRNt
reactant: MODEL1310110024#
name: transport into the mitochondria (carnitine)
is: SBO:0000185
product: MODEL1310110024#
kinetic law: MODEL1310110024#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110024#
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110024#_f4f674ef_fd80_4e02_81aa_956d2b74d4ec
has only substance units: false
is: Q92781
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
name: RDH5
is encoded by: hsa:5959
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110024#_abd8e074_d24b_4012_b203_48d40a8d4b54
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:7355
name: SLC35A2
is: P78381
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_5d8b6a75_047b_47cc_8cd2_9a37559b171b
type: Species
is: SBO:0000252
is encoded by: hsa:6319
is: O00767
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
name: SCD

metaR r1614
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110024#
is described by: ECO:0000000
modifier: MODEL1310110024#
fast: false
type: Reaction
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_a08c7319_0e90_4be9_b5a1_ec3f2086d88c
is: P49748
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:37
is: SBO:0000252
has only substance units: false
type: Species
name: ACADVL
boundary condition: true

metaM acnam n
is: HMDB00230
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
name: N-acetylneuraminate
is: CHEBI:35418
is: SBO:0000247
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
has only substance units: false

metaR r1789
is described by: ECO:0000000
reversible: false
is: SBO:0000185
modifier: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110024#
name: Y+LAT2 Utilized transport
product: MODEL1310110024#
type: Reaction

metaR TDPm
product: MODEL1310110024#
name: thiamin pyrophosphatase, mitochondrial
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: 3.6.1.15 Confidence Level: 2 AUTHORS: PMID:9755848 NOTES:_01-25-05 IT
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110024#
type: Reaction
kinetic law: MODEL1310110024#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110024#_6dd897f9_34b2_4ffb_9fa3_44fe61c4cf45
name: FUK
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
constant: false
is: Q8N0W3
has only substance units: false
initial concentration: NaN
is encoded by: hsa:197258

metaM octa e
notes: FORMULA: C8H15O2 CHARGE: -1
is: C06423
initial amount: NaN
has only substance units: false
is: CHEBI:25646
constant: false
type: Species
initial concentration: 1.0
name: octanoate (n-C8:0)
boundary condition: false
is: SBO:0000247
is: HMDB00482

metaM lac L e
type: Species
is: SBO:0000247
constant: false
is: HMDB00190
has only substance units: false
initial amount: NaN
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
initial concentration: 1.0
is: CHEBI:16651
boundary condition: false
name: (S)-lactate

metaM HC01180 c
initial amount: NaN
is: CHEBI:58694
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-4-3(1-16-19(10,11)12)18-6(9,5(4)8)2-17-20(13,14)15/h3-5,7-9H,1-2H2,(H2,10,11,12)(H2,13,14,15)/p-4/t3-,4+,5+,6?/m1/s1 EHMN_ABBREVIATION: C03785
boundary condition: false
constant: false
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
name: D-tagatofuranose 1,6-bisphosphate(4-)

metaR 41R1H2MAE12BOOX
is described by: ECO:0000269
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
reactant: MODEL1310110024#
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.4.3.4
kinetic law: MODEL1310110024#
reversible: false
name: 4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing)

metaR EX tsul LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiosulfate exchange
type: Reaction

metaR r2137
fast: false
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
reversible: true
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
modifier: MODEL1310110024#
is described by: ECO:0000000
product: MODEL1310110024#
is: SBO:0000185
reactant: MODEL1310110024#

metaR r1613
fast: false
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110024#
reversible: true

metaR EX dlnlcg LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: dihomo-gamma-linolenic acid (n-6) exchange
type: Reaction

metaR RETH1e
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110024#
reactant: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
name: retinyl ester hydrolase (9-cis), extracellular
fast: false
reversible: false
kinetic law: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_9319bda8_4340_4b1d_805b_95203b7b52d4
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:57835
boundary condition: true
name: SLC4A5
is: SBO:0000252
initial amount: NaN
constant: false

metaM lys L m
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
name: L-lysinium(1+)
is: SBO:0000247
type: Species
is: CHEBI:32551
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
has only substance units: false
is: HMDB00182

metaR PPM
reversible: true
modifier: MODEL1310110024#
is described by: ECO:0000000
name: phosphopentomutase
product: MODEL1310110024#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (5236.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/5.4.2.2
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#

metaR RE3243R
modifier: MODEL1310110024#
name: RE3243
reactant: MODEL1310110024#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790,PMID:11567032,PMID:2114179 NOTES:
type: Reaction
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110024#
fast: false
product: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_0469fb65_425e_4e55_b089_0551f05dafc6
is: Q16775
constant: false
type: Species
is encoded by: hsa:3029
initial concentration: NaN
initial amount: NaN
name: HAGH
is: SBO:0000252
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110024#_ba1b0271_c3eb_4856_98a4_000347477c9b
constant: false
is: SBO:0000252
initial amount: NaN
name: NDUFS2
has only substance units: false
boundary condition: true
is: B7Z792
initial concentration: NaN
type: Species
is encoded by: hsa:4720

metaR r1612
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
reactant: MODEL1310110024#
reversible: true
product: MODEL1310110024#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR SIAT9g
name: Lactosylceramide alpha-2,3-sialyltransferase, Golgi apparatus
fast: false
type: Reaction
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.4.99.9
product: MODEL1310110024#
is: SBO:0000176
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (8869.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.9 Confidence Level: 4 AUTHORS: PMID:9822625 NOTES:NJ
reversible: false
is described by: ECO:0000000

metaR NADS2
reactant: MODEL1310110024#
is: SBO:0000176
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
name: NAD synthase (glutamine-hydrolysing)
is described by: ECO:0000269
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/6.3.5.1
reversible: false
notes: GENE_ASSOCIATION: (55191.1) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_44b42007_ba11_48b3_93cd_7ef54acad8fb
constant: false
is encoded by: hsa:AL048840
initial concentration: NaN
is: SBO:0000252
name: _AL048840_1_c
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true

metaM tmndnccrn m
boundary condition: false
has only substance units: false
notes: FORMULA: C27H43NO4 CHARGE: 0 INCHI: InChI=1/C28H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-28(32)33-26(24-27(30)31)25-29(2,3)4/h6-7,9-10,12-13,15-16,18-19,26H,5,8,11,14,17,20-25H2,1-4H3/t26-/m0/s1
is: SBO:0000247
type: Species
is: CHEBI:0
initial concentration: 1.0
is: C00378
constant: false
is: HMDB00235
initial amount: NaN
name: Timnodonyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110024#_ab93130e_b75e_470b_baf1_fe74aa9efe17
initial amount: NaN
is encoded by: hsa:1103
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is: D3DX95
is: SBO:0000252
name: CHAT

http://identifiers.org/biomodels.db/MODEL1310110024#_8ebb8863_300b_4bb4_a900_ebc4f95b0c67
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
name: EGFR
is: P00533
is: SBO:0000252
boundary condition: true
is encoded by: hsa:1956

metaM h2o2 x
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
has only substance units: false
name: Hydrogen peroxide
is: C00027
boundary condition: false
is: HMDB03125
is: CHEBI:16240
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_6db794af_f7af_49df_823b_4c12f75adee0
has only substance units: false
initial concentration: NaN
name: _W74642_1_c
is encoded by: hsa:W74642
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaM tchola x
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:36257
boundary condition: false
is: HMDB00036
has only substance units: false
name: taurocholate
notes: FORMULA: C26H45NO7S CHARGE: 0 INCHI: InChI=1S/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122

http://identifiers.org/biomodels.db/MODEL1310110024#_7fb399a2_70f5_4e13_ae71_65f38c92e0c4
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
name: SLC6A9
is encoded by: hsa:6536
has only substance units: false
is: B7Z3W8

metaM lys L n
is: HMDB00182
name: L-lysinium(1+)
has only substance units: false
constant: false
is: CHEBI:32551
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
type: Species
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110024#_b07a0e60_d750_4d02_bf61_bb4019f6d63e
is: Q53Y83
constant: false
name: GLA
is encoded by: hsa:2717
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_5c1c4b63_de52_4f4b_b153_f59cecfedecd
is encoded by: hsa:3030
initial amount: NaN
constant: false
is: E9KL44
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
name: HADHA

metaR CYTK2n
is: SBO:0000176
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
product: MODEL1310110024#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110024#
name: cytidylate kinase (dCMP),nuclear
fast: false
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_d9c80722_55b2_44cb_b68c_6043a5f0ea1e
name: HMOX2
initial amount: NaN
has only substance units: false
is encoded by: hsa:3163
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is: P30519
is: SBO:0000252

metaM acnam l
initial concentration: 1.0
is: HMDB00230
type: Species
name: N-acetylneuraminate
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:35418
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
has only substance units: false
is: SBO:0000247

metaM ttdcrn m
initial amount: NaN
type: Species
constant: false
name: tetradecanoyl carnitine
boundary condition: false
initial concentration: 1.0
is: HMDB05066
is: SBO:0000247
notes: FORMULA: C21H41NO4 CHARGE: 0 INCHI: InChI=1/C21H41NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-21(25)26-19(17-20(23)24)18-22(2,3)4/h19H,5-18H2,1-4H3/t19-/m1/s1
is: http://identifiers.org/pubchem.compound/3413344
has only substance units: false

metaR DHORTS
fast: false
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 3.5.2.3 Confidence Level: 4 AUTHORS: PMID:2565865,PMID:8619816 NOTES:
modifier: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
reversible: true
name: dihydroorotase
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.3.2

http://identifiers.org/biomodels.db/MODEL1310110024#_f5fb2a7f_bb9c_4974_827b_67c18495a5d8
constant: false
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:AI697028
initial amount: NaN
name: _AI697028_1_m
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_3bf457af_318a_447a_b5fd_704af494707e
type: Species
is: SBO:0000252
is encoded by: hsa:4357
has only substance units: false
initial concentration: NaN
constant: false
is: P25325
name: MPST
initial amount: NaN
boundary condition: true

metaR RE0383C
reversible: true
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
reactant: MODEL1310110024#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.2
product: MODEL1310110024#
name: RE0383
kinetic law: MODEL1310110024#
is: SBO:0000176

metaR r1611
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110024#
product: MODEL1310110024#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110024#
type: Reaction
reversible: true

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

metaR r0119
product: MODEL1310110024#
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:11278832,PMID:4310599 NOTES:
kinetic law: MODEL1310110024#
is: SBO:0000176
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/5.1.3.14
reversible: false
type: Reaction
is described by: ECO:0000000
name: Guanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
fast: false

metaM sprm e
is: SBO:0000247
name: spermine(4+)
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
is: HMDB01256
initial amount: NaN
notes: FORMULA: C10H30N4 CHARGE: 4 INCHI: InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2 HEPATONET_1.0_ABBREVIATION: HC00525 EHMN_ABBREVIATION: C00750
constant: false
is: CHEBI:45725

http://identifiers.org/biomodels.db/MODEL1310110024#_18e32326_0db7_405f_ab5f_fc375db33dba
type: Species
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: A8K7W0
initial concentration: NaN
name: VNN2
is encoded by: hsa:8875

metaR GLYtp
reversible: true
reactant: MODEL1310110024#
name: glycine passive transport to peroxisome
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:TDV
product: MODEL1310110024#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false

metaR PGCD
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.95
name: phosphoglycerate dehydrogenase
reactant: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (26227.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.1.95 Confidence Level: 4 AUTHORS: PMID:10713460 NOTES:
reversible: false
fast: false
is: SBO:0000176
kinetic law: MODEL1310110024#

metaR RBTt
is described by: ECO:0000000
kinetic law: MODEL1310110024#
product: MODEL1310110024#
is: SBO:0000185
reactant: MODEL1310110024#
name: ribitol transport via passive diffusion
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
reversible: false

metaR FAEL183
modifier: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
name: fatty-acyl-CoA elongation (n-C18:3CoA)
is: SBO:0000176
kinetic law: MODEL1310110024#
product: MODEL1310110024#
fast: false
reactant: MODEL1310110024#
reversible: false
is described by: ECO:0000000

metaR FALDH
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110024#
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
kinetic law: MODEL1310110024#
name: formaldehyde dehydrogenase
is version of: http://identifiers.org/ec-code/1.1.1.1
is described by: ECO:0000269
product: MODEL1310110024#
is: SBO:0000176

metaR N2M2NMASNtly
name: n2m2nmasn transport, extracellular to lysosome
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
type: Reaction
reversible: false
is described by: ECO:0000000
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
is: SBO:0000185

metaR DNDPt23m
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110024#
type: Reaction
product: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110024#
reversible: false
name: dTDP transport via dGTP antiport

http://identifiers.org/biomodels.db/MODEL1310110024#_63523b39_5e6d_4747_8193_b730d28fde29
name: ADH4
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
is: P08319
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:127

metaR 5ADTSTSTERONESte
is: SBO:0000185
product: MODEL1310110024#
reversible: true
reactant: MODEL1310110024#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
kinetic law: MODEL1310110024#
type: Reaction
name: sulfonated testosterone transport

http://identifiers.org/biomodels.db/MODEL1310110024#_41bc26b5_bfcf_4986_bb69_1560579c96f4
initial concentration: NaN
boundary condition: true
is: G3XAJ0
constant: false
is encoded by: hsa:80724
is: SBO:0000252
name: ACAD10
initial amount: NaN
type: Species
has only substance units: false

metaR r1610
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110024#
product: MODEL1310110024#
kinetic law: MODEL1310110024#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110024#_fce91571_6ef4_49bd_9eb3_ac876503a807
has only substance units: false
initial amount: NaN
is: O95299
is: SBO:0000252
is encoded by: hsa:4705
name: NDUFA10
boundary condition: true
initial concentration: NaN
constant: false
type: Species

metaR EX fald LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of formaldehyde
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_898e8373_aa31_4615_abc5_c0dd6db5e257
initial concentration: NaN
name: SLC5A8
is: Q8N695
is: SBO:0000252
constant: false
is encoded by: hsa:160728
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species

metaR r1365
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110024#
name: Vesicular transport
is described by: ECO:0000000
kinetic law: MODEL1310110024#
product: MODEL1310110024#

metaM hmgcoa x
type: Species
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
has only substance units: false
name: Hydroxymethylglutaryl-CoA
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:15467
initial concentration: 1.0
is: SBO:0000247
is: HMDB01375

metaR PI4PLC
is: SBO:0000176
reversible: false
name: phosphatidylinositol 4-phosphate phospholipase C
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.1.4.11
type: Reaction
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
modifier: MODEL1310110024#

metaR 3MOPte
is described by: ECO:0000134
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
reversible: true
fast: false
type: Reaction
name: Transport of 3-methyl-2-oxopentanoate
product: MODEL1310110024#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR KSII CORE4tly
product: MODEL1310110024#
is described by: ECO:0000000
is: SBO:0000185
fast: false
kinetic law: MODEL1310110024#
type: Reaction
name: keratan sulfate II (core 4) transport, extracellular to lysosome
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false

metaR FAEL184
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
type: Reaction
reversible: false
name: fatty-acyl-CoA elongation (n-C20:4CoA)
is: SBO:0000176
modifier: MODEL1310110024#
product: MODEL1310110024#
fast: false
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#

metaR PHYTt
type: Reaction
kinetic law: MODEL1310110024#
is: SBO:0000185
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
name: fatty acid transport via diffusion
fast: false
is described by: ECO:0000000
product: MODEL1310110024#
reversible: true

metaR r1364
type: Reaction
fast: false
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110024#
is described by: ECO:0000000
name: Vesicular transport
reversible: false
is: SBO:0000185
product: MODEL1310110024#

metaR NDPK8n
type: Reaction
product: MODEL1310110024#
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
is described by: ECO:0000304
reactant: MODEL1310110024#
is: SBO:0000176
modifier: MODEL1310110024#
fast: false
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear

metaM c12dccoa x
constant: false
boundary condition: false
initial concentration: 1.0
is: C14143
type: Species
is: HMDB04047
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
name: dodecanedioylcoa
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaR GLYtm
is: SBO:0000185
type: Reaction
fast: false
name: glycine passive transport to mitochondria
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
is described by: ECO:0000000

metaM 1pyr5c m
has only substance units: false
boundary condition: false
is: SBO:0000247
is: C03912
is: HMDB01301
initial concentration: 1.0
name: 1-Pyrroline-5-carboxylate
constant: false
is: CHEBI:15893
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
initial amount: NaN
type: Species

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_93c63c0e_dbc1_4604_8474_a8afeec586e0
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:60481
is: SBO:0000252
name: ELOVL5
constant: false
initial amount: NaN
is: F6SH78
has only substance units: false

metaR COAtg
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
kinetic law: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110024#
name: CoA transport in Golgi via diffusion
fast: false

metaR EX arab L LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_746ee9af_cb23_4c6b_aef0_96c96018fc25
has only substance units: false
name: ABAT
constant: false
initial amount: NaN
is encoded by: hsa:18
type: Species
boundary condition: true
initial concentration: NaN
is: P80404
is: SBO:0000252

metaR APAT2rm
is: SBO:0000176
product: MODEL1310110024#
modifier: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000212
name: 3-Aminopropanoate:2-oxoglutarate aminotransferase (m)
is version of: http://identifiers.org/ec-code/2.6.1.19
type: Reaction
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 2.6.19.4 Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
fast: false
kinetic law: MODEL1310110024#
reversible: true

metaM dcmp n
has only substance units: false
name: dCMP(2-)
constant: false
type: Species
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
is: CHEBI:57566
boundary condition: false
initial amount: NaN
is: HMDB01202
is: SBO:0000247
initial concentration: 1.0

metaM eitetcoa x
name: 5,8,11,14-eicosatetraenoylcoa
constant: false
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/24892790
has only substance units: false
boundary condition: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
is: SBO:0000247
type: Species

metaR r2420
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is: SBO:0000185
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
reversible: true

metaR OCDCEAtr
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110024#
is: SBO:0000185
product: MODEL1310110024#
fast: false
name: fatty acid transport via diffusion
reversible: true

metaM octa c
notes: FORMULA: C8H15O2 CHARGE: -1
boundary condition: false
is: CHEBI:25646
has only substance units: false
is: SBO:0000247
is: HMDB00482
initial amount: NaN
type: Species
constant: false
is: C06423
initial concentration: 1.0
name: octanoate (n-C8:0)

metaR ACHtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
reversible: true
name: Acetylcholin transport, nuclear trhough pores
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000000
product: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_efc768d2_ff59_472a_9dff_fb83d16da254
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
name: SLC1A5
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6510
is: Q15758

http://identifiers.org/biomodels.db/MODEL1310110024#_5cbdb615_9880_4db7_ab8d_af21aca04d0b
is: SBO:0000252
is encoded by: hsa:3417
constant: false
is: O75874
initial amount: NaN
initial concentration: NaN
name: IDH1
boundary condition: true
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_51d7ab59_230d_4f50_8a7c_904a59be7fbc
is: Q86VV3
initial amount: NaN
constant: false
name: ENTPD1
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:953
initial concentration: NaN
boundary condition: true

metaM Rtotalcoa c
name: R total Coenzyme A
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
is: HMDB01448
type: Species
boundary condition: false
is: CHEBI:16189
constant: false

metaR r2139
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110024#
type: Reaction
kinetic law: MODEL1310110024#
fast: false
reversible: true
modifier: MODEL1310110024#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110024#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110024#_63143942_7958_4f90_bebc_a42a1c9632e8
is: SBO:0000297
has only substance units: false
boundary condition: true
type: Species
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
constant: false
is encoded by: hsa:518
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_8783e727_8354_4ca1_878e_79848682cd15
constant: false
initial amount: NaN
name: HAO1
boundary condition: true
is: Q9UJM8
is encoded by: hsa:54363
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species

metaR C161CPT1
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110024#
reversible: false
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:TDV
is: SBO:0000176
name: production of palmitoleoylcarnitine
is described by: ECO:0000000
reactant: MODEL1310110024#
fast: false
type: Reaction
kinetic law: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_515d19c8_0981_4e7e_af74_bbb48af14a0a
is encoded by: hsa:64802
name: NMNAT1
type: Species
is: B1AN63
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaM lys L c
boundary condition: false
is: CHEBI:32551
constant: false
has only substance units: false
name: L-lysinium(1+)
initial amount: NaN
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB00182

metaR FAOXC16BRx
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16br)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_53837eac_fbc0_4651_b532_de526cbbbfc5
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:522
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: Q6NZ59
name: ATP5J

http://identifiers.org/biomodels.db/MODEL1310110024#_e2d06a03_62e2_419e_9865_4c32fe0316b2
type: Species
initial concentration: NaN
boundary condition: true
name: IMPA1
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:3612
is: B7Z6Q4

metaM btn e
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
name: Biotin
has only substance units: false
type: Species
is: C00120
is: CHEBI:3420
initial concentration: 1.0
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: HMDB00030

metaM hs deg19 l
type: Species
notes: FORMULA: C43H67N2O42S2 CHARGE: -3
boundary condition: false
is: HMDB01352
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
name: heparan sulfate, degradation product 19
initial amount: NaN
is: CHEBI:17180

metaM ksi pre17 g
is: CHEBI:28067
is: SBO:0000247
initial concentration: 1.0
constant: false
name: keratan sulfate I biosynthesis, precursor 17
boundary condition: false
type: Species
notes: FORMULA: C157H252N11O127S5X CHARGE: -6
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_cb68d10b_63b2_4c53_8e16_901e1b0460df
name: MIA3
is encoded by: hsa:375056
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is: Q5JRA6
is: SBO:0000252

metaR C161CPT2
kinetic law: MODEL1310110024#
name: transport of Hexadecenoyl-CoA into mitochondrial matrix
fast: false
reactant: MODEL1310110024#
product: MODEL1310110024#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:TDV
type: Reaction
modifier: MODEL1310110024#

metaM hexdiac r
name: hexadecanediocacid
is: HMDB00672
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C16H28O4 CHARGE: -2
has only substance units: false
constant: false
is: C08260

http://identifiers.org/biomodels.db/MODEL1310110024#_937d417a_1838_4c11_bd94_b3984b68be09
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: O15427
is encoded by: hsa:9123
constant: false
initial concentration: NaN
type: Species
has only substance units: false
name: SLC16A3

metaM undcoa m
notes: FORMULA: C32H52N7O17P3S CHARGE: -4
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
name: undecanoylcoa
is: HMDB13114
has only substance units: false
initial concentration: 1.0

metaR COAtm
kinetic law: MODEL1310110024#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110024#
reversible: true
fast: false
name: CoA transporter
is: SBO:0000185
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
reactant: MODEL1310110024#

metaR CYSO
is version of: http://identifiers.org/ec-code/1.13.11.20
fast: false
kinetic law: MODEL1310110024#
is described by: ECO:0000269
reactant: MODEL1310110024#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1036.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES:IT
product: MODEL1310110024#
name: cysteine oxidase
type: Reaction
reversible: false
modifier: MODEL1310110024#

metaR r0917
kinetic law: MODEL1310110024#
reversible: true
reactant: MODEL1310110024#
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110024#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction

metaR CDPDAGtm
name: intracellular transport
reversible: true
fast: false
product: MODEL1310110024#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ

metaR EX ttdca LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecanoate (n-C14:0)
type: Reaction

metaR r0226
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:6882460,PMID:962851 NOTES:
kinetic law: MODEL1310110024#
product: MODEL1310110024#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110024#
fast: false
modifier: MODEL1310110024#
name: 5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110024#_2bd9dc39_9efe_4631_b789_86aef9e8e42b
name: PANK3
constant: false
has only substance units: false
type: Species
boundary condition: true
is: Q9H999
initial amount: NaN
is encoded by: hsa:79646
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110024#_3aea17df_b955_432e_8c2e_33c48ae78f7e
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: SLC27A2
initial concentration: NaN
constant: false
boundary condition: true
is: O14975
is encoded by: hsa:11001

http://identifiers.org/biomodels.db/MODEL1310110024#_c8321cd1_8078_437a_8399_d309cfd2493f
is encoded by: hsa:1339
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: Q02221
initial concentration: NaN
constant: false
name: COX6A2
type: Species

metaR 5HOXINDACTO2OX
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.2.3.1
name: 5-Hydroxyindoleacetaldehyde:oxygen oxidoreductase
type: Reaction
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.2.3.1 Confidence Level: 2 AUTHORS: PMID:11306106 NOTES:SAB questionable--balanced, but h2o2 production is based on an obscure comment in entrez
product: MODEL1310110024#
reversible: false
reactant: MODEL1310110024#
modifier: MODEL1310110024#
is: SBO:0000176
kinetic law: MODEL1310110024#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110024#_34f597e8_a22a_4dc4_b93d_bea681530dd1
is: Q9H845
name: ACAD9
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:28976

metaR RE3628M
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/5.3.3.8
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
name: RE3628
reactant: MODEL1310110024#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110024#
is: SBO:0000176

metaR COAtn
is: SBO:0000185
reversible: true
reactant: MODEL1310110024#
type: Reaction
kinetic law: MODEL1310110024#
is described by: ECO:0000000
fast: false
product: MODEL1310110024#
name: coenzyme A transport, nuclear
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaM lys L e
name: L-lysinium(1+)
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:32551
is: HMDB00182
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
type: Species

metaM mi1345p c
is: HMDB01059
has only substance units: false
name: 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
notes: FORMULA: C6H8O18P4 CHARGE: -8 INCHI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/p-8/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C01272
is: CHEBI:57895
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247

metaR COQ3m
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.1.114
product: MODEL1310110024#
reversible: false
name: methyltransferase COQ3
modifier: MODEL1310110024#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51805.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10777520,PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_2.1.1.114 IT
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110024#_401f4da4_ba77_478d_b34b_032713444351
is encoded by: hsa:5279
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: Q92535
name: PIGC
has only substance units: false
constant: false

metaM btn c
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
name: Biotin
notes: FORMULA: C10H15N2O3S CHARGE: -1
type: Species
initial concentration: 1.0
is: C00120
is: CHEBI:3420
is: HMDB00030
boundary condition: false

metaR GALASE18ly
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
name: beta-galactosidase, lysosomal
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#

metaR r1725
modifier: MODEL1310110024#
is described by: ECO:0000000
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
name: Y+LAT2 Utilized transport
reactant: MODEL1310110024#
reversible: false
product: MODEL1310110024#
is: SBO:0000185

metaM cholp g
is: C00588
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:295975
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
has only substance units: false
constant: false
name: choline phosphate(1-)
type: Species
initial concentration: 1.0

metaR GALt4
product: MODEL1310110024#
reactant: MODEL1310110024#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
is: SBO:0000185
name: galactose transport via sodium symport
is described by: ECO:0000269
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_0c207f71_56c6_42b2_9f7e_7bfe35162966
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: O14732
is encoded by: hsa:3613
name: IMPA2
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_d75488ed_1689_4d6a_963b_de77c496ae77
boundary condition: true
is encoded by: hsa:55568
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
name: GALNT10
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_7bd6c015_31e5_4d9b_8e15_4e6bb6afc953
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: GOT2
constant: false
type: Species
is: SBO:0000252
is: P00505
is encoded by: hsa:2806

metaR FATP9t
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.7
modifier: MODEL1310110024#
is: SBO:0000185
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
fast: false
reactant: MODEL1310110024#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110024#
name: fatty acid electroneutral transport
is described by: ECO:0000269
product: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_b418cdb9_9ff6_4722_8e9b_b5e918f0fc29
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:8527
name: DGKD
constant: false
initial amount: NaN

metaR FAOXC9C7m
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C9-->C7)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_a0d4c8bf_cd94_444e_a46b_f96a489e447a
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: Q16774
is: SBO:0000252
name: GUK1
boundary condition: true
is encoded by: hsa:2987
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_6844a5c1_6cbd_400f_b252_cf9b099b23a1
type: Species
initial concentration: NaN
is encoded by: hsa:64077
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
is: Q9H008
name: LHPP

metaR PPA
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:
modifier: MODEL1310110024#
is described by: ECO:0000269
product: MODEL1310110024#
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.1
fast: false
name: inorganic diphosphatase
kinetic law: MODEL1310110024#
is: SBO:0000176
type: Reaction

metaR O2ter
name: O2 transport, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
type: Reaction
product: MODEL1310110024#
is described by: ECO:0000000
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110024#_bda27347_01e6_4b59_93e7_764ce425b51e
is encoded by: hsa:286297
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: _286297_1_c
type: Species

metaM dmpp x
has only substance units: false
constant: false
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h3H,4H2,1-2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00213 EHMN_ABBREVIATION: C00235
is: CHEBI:57623
boundary condition: false
name: prenyl diphosphate(3-)
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB01120
initial amount: NaN

metaR r0915
type: Reaction
reversible: true
reactant: MODEL1310110024#
product: MODEL1310110024#
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110024#

metaR DADA
fast: false
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:JLR
kinetic law: MODEL1310110024#
is: SBO:0000176
reactant: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
name: Deoxyadenosine deaminase
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.5.4.4

metaM formcoa x
type: Species
constant: false
initial amount: NaN
is: HMDB03419
is: SBO:0000247
name: formyl-CoA(4-)
boundary condition: false
is: CHEBI:57376
notes: FORMULA: C22H32N7O17P3S CHARGE: -4 INCHI: InChI=1S/C22H36N7O17P3S/c1-22(2,17(33)20(34)25-4-3-13(31)24-5-6-50-11-30)8-43-49(40,41)46-48(38,39)42-7-12-16(45-47(35,36)37)15(32)21(44-12)29-10-28-14-18(23)26-9-27-19(14)29/h9-12,15-17,21,32-33H,3-8H2,1-2H3,(H,24,31)(H,25,34)(H,38,39)(H,40,41)(H2,23,26,27)(H2,35,36,37)/p-4/t12-,15-,16-,17+,21-/m1/s1 EHMN_ABBREVIATION: C00798
has only substance units: false
initial concentration: 1.0

metaR FRDPtcr
kinetic law: MODEL1310110024#
is described by: ECO:0000134
reactant: MODEL1310110024#
reversible: true
fast: false
type: Reaction
product: MODEL1310110024#
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
is: SBO:0000185

metaM m4mpdol L r
is: SBO:0000247
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
type: Species
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:37633
notes: FORMULA: C1540H2528N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
initial amount: NaN
initial concentration: 1.0

metaR SPHS1Pte
fast: false
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
type: Reaction
name: sphingosine-1-phosphate transport
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ

metaR COAtl
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:6313022 NOTES:IT
type: Reaction
product: MODEL1310110024#
reversible: true
is described by: ECO:0000000
name: CoA transport in lysosome via diffusion
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false

metaR NACHEX12ly
reactant: MODEL1310110024#
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reversible: false
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110024#
fast: false
is: SBO:0000176
product: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_314e2589_a99d_4d11_943e_f6339ae99e43
type: Species
is encoded by: hsa:10873
initial concentration: NaN
initial amount: NaN
is: Q6TCH8
name: ME3
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110024#_66d7aeb3_0cc7_487b_974f_5af6567b1148
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3030
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
name: HADHA
is: E9KL44

http://identifiers.org/biomodels.db/MODEL1310110024#_3adf9d9c_1423_4f5f_9b84_6780166dee05
has only substance units: false
constant: false
is encoded by: hsa:56894
is: SBO:0000252
name: AGPAT3
boundary condition: true
is: Q9NRZ7
initial concentration: NaN
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_5044bfea_e5c8_47cd_93cc_bfbd0e9bb476
type: Species
is: B3KVI7
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:3712
name: IVD
boundary condition: true

metaM 4hphac e
has only substance units: false
is: HMDB00020
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:48999
type: Species
name: 4-hydroxyphenylacetate
is: SBO:0000247
constant: false
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642

metaR FACOAL2042
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
is described by: ECO:0000000
is: SBO:0000176
name: fatty-acid--CoA ligase
fast: false
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA alternate to arachidonic acid (n-3 rather than n-6) NJ
type: Reaction
product: MODEL1310110024#

metaR GLUPRT
fast: false
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.4.2.14
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:
name: glutamine phosphoribosyldiphosphate amidotransferase
type: Reaction
kinetic law: MODEL1310110024#
product: MODEL1310110024#
is: SBO:0000176
reactant: MODEL1310110024#
is described by: ECO:0000269
reversible: false

metaR HMBS
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (3145.1) SUBSYSTEM: Heme synthesis EC Number: 4.3.1.8 Confidence Level: 2 AUTHORS: PMID:2875434 NOTES:
reversible: false
is: SBO:0000176
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.5.1.61
type: Reaction
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
fast: false
name: hydroxymethylbilane synthase

metaR r2408
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false
modifier: MODEL1310110024#
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
product: MODEL1310110024#
is described by: ECO:0000000

metaR EX 4pyrdx LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Pyridoxate exchange
type: Reaction

metaR r0650
reversible: true
type: Reaction
modifier: MODEL1310110024#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/4.1.1.36
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
reactant: MODEL1310110024#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110024#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110024#_4c377086_b5b2_4ca2_8ab0_df506ea1b927
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false
name: NDUFS7
is: O75251
is encoded by: hsa:374291

metaM srtn c
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:350546
constant: false
has only substance units: false
is: HMDB00259
boundary condition: false
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
name: serotonin(1+)
type: Species

metaM cyst L c
name: L-cystathionine
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:17482
boundary condition: false
initial amount: NaN
notes: FORMULA: C7H14N2O4S CHARGE: 0 INCHI: InChI=1S/C7H14N2O4S/c8-4(6(10)11)1-2-14-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00916
is: HMDB00099
type: Species
constant: false

metaM ksi deg11 l
initial concentration: 1.0
notes: FORMULA: C180H289N12O158S9 CHARGE: -9
has only substance units: false
constant: false
is: CHEBI:12936
is: HMDB00143
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
name: keratan sulfate I, degradation product 11

http://identifiers.org/biomodels.db/MODEL1310110024#_d6c4652e_2e6a_4ef9_aaef_a76b937f489c
is: SBO:0000252
name: B3GALT5
type: Species
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:10317
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110024#_eec96b14_8c63_4cac_ba5a_ea7067627b5d
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
name: LDHA
boundary condition: true
is: P00338
has only substance units: false
constant: false
is encoded by: hsa:3939

metaM didp n
has only substance units: false
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
is: CHEBI:28823
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
name: dIDP
is: HMDB03536

metaM ak2lgchol hs c
is: C04317
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317
has only substance units: false
boundary condition: false
name: 1-alkyl 2-lysoglycerol 3-phosphocholine
is: http://identifiers.org/pubchem.compound/6975
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110024#_7b0580ed_095e_4fdf_85f5_3e656f50b3e9
is encoded by: hsa:85365
name: ALG2
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true

metaR PYAM5POr
reactant: MODEL1310110024#
modifier: MODEL1310110024#
fast: false
type: Reaction
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:6380540 NOTES:NCD IT
kinetic law: MODEL1310110024#
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.4.3.5
name: pyridoxamine 5'-phosphate oxidase
is described by: ECO:0000269

metaR DOLPGT1 Uer
is: SBO:0000176
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
is described by: ECO:0000000
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
fast: false
product: MODEL1310110024#
reversible: false
notes: GENE_ASSOCIATION: (29929.1) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10359825 NOTES:EC 2.4.1.- NCD
modifier: MODEL1310110024#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.267

http://identifiers.org/biomodels.db/MODEL1310110024#_238aaa6c_809c_45ba_aab7_105ca9fc3401
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
constant: false
name: AASS
is: A4D0W4
is encoded by: hsa:10157
has only substance units: false
initial amount: NaN

metaR RE1516M
is version of: http://identifiers.org/ec-code/1.3.99.13
reactant: MODEL1310110024#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
reversible: true
modifier: MODEL1310110024#
product: MODEL1310110024#
fast: false
name: RE1516
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.3.3.6

metaM 1p3h5c c
has only substance units: false
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
is: HMDB01369
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:6151

metaR LGTHL
is version of: http://identifiers.org/ec-code/4.4.1.5
is described by: ECO:0000269
product: MODEL1310110024#
type: Reaction
kinetic law: MODEL1310110024#
fast: false
modifier: MODEL1310110024#
reversible: false
is: SBO:0000176
reactant: MODEL1310110024#
name: lactoylglutathione lyase
notes: GENE_ASSOCIATION: (2739.1) SUBSYSTEM: Pyruvate metabolism EC Number: 4.4.1.5 Confidence Level: 4 AUTHORS: PMID:7684374,PMID:8449929 NOTES:IF

metaM cspg a e
is: CHEBI:17568
is: HMDB00300
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: C00106
initial amount: NaN
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
has only substance units: false
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
is: SBO:0000247

metaR ALAR
kinetic law: MODEL1310110024#
type: Reaction
fast: false
name: alanine racemase
is described by: ECO:0000212
is: SBO:0000176
product: MODEL1310110024#
reactant: MODEL1310110024#
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (11212.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 5.1.1.1 Confidence Level: 1 AUTHORS: NOTES:
reversible: true

metaR DOLP Lter
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
product: MODEL1310110024#
fast: false
name: dolichol phosphate flippase (liver)
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reversible: false

metaM 4hpro LT e
initial amount: NaN
is: SBO:0000247
name: trans-4-hydroxy-L-proline
is: HMDB00725
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
constant: false
has only substance units: false

metaM gcald c
is: HMDB03344
initial amount: NaN
notes: FORMULA: C2H4O2 CHARGE: 0 INCHI: InChI=1S/C2H4O2/c3-1-2-4/h1,4H,2H2 EHMN_ABBREVIATION: C00266
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
name: glycolaldehyde
type: Species
is: CHEBI:17071
is: SBO:0000247

metaR r0242
modifier: MODEL1310110024#
type: Reaction
product: MODEL1310110024#
is: SBO:0000176
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:
is version of: http://identifiers.org/ec-code/6.2.1.1
kinetic law: MODEL1310110024#
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110024#

metaM 4fumacac c
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB01268
is: CHEBI:18034
initial amount: NaN
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1+ HEPATONET_1.0_ABBREVIATION: HC00648 EHMN_ABBREVIATION: C01061
boundary condition: false
has only substance units: false
name: 4-fumarylacetoacetate(2-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_52912f27_01e2_4af7_bacb_dd28b2e3d493
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:6541
is: SBO:0000252
name: SLC7A1
initial concentration: NaN
is: P30825
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_087005b4_551c_4c93_92b8_5bb862ef6d8c
is: Q6P1K9
boundary condition: true
is encoded by: hsa:80025
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
name: PANK2
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_e22159b4_c95b_4cbc_a716_5bb3beef7097
name: NDUFAB1
is: SBO:0000252
constant: false
is encoded by: hsa:4706
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
is: O14561

http://identifiers.org/biomodels.db/MODEL1310110024#_5f6bca3d_7fc5_4f13_bc6c_6fe3498c1f62
is encoded by: hsa:5295
type: Species
name: PIK3R1
constant: false
initial amount: NaN
is: E7EX19
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR DOLASNT Uer
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.119
is: SBO:0000176
name: Dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase (uterus)
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (6185.1 and 1650.1 and 6184.1 and 1603.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.119 Confidence Level: 0 AUTHORS: PMID:8413235,PMID:9367678 NOTES:NCD
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
is described by: ECO:0000000
reactant: MODEL1310110024#
fast: false

metaR S6TASE20ly
kinetic law: MODEL1310110024#
name: N-acetylglucosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reversible: true
product: MODEL1310110024#
is described by: ECO:0000000
reactant: MODEL1310110024#
type: Reaction
fast: false
is: SBO:0000176
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.1.6.14

metaM ocdcea e
is: CHEBI:0
has only substance units: false
notes: FORMULA: C18H33O2 CHARGE: -1
is: HMDB00207
type: Species
initial amount: NaN
initial concentration: 1.0
is: C00712
boundary condition: false
constant: false
is: SBO:0000247
name: octadecenoate (n-C18:1)

http://identifiers.org/biomodels.db/MODEL1310110024#_2156fb10_1d9c_4ec5_86b2_c0381008fe2f
is: Q15067
type: Species
has only substance units: false
name: ACOX1
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:51
is: SBO:0000252

metaM pcrn c
has only substance units: false
name: propionyl-carnitine
constant: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/107738
is: HMDB00824
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
type: Species

metaR DM Asn X Ser Thr ly
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Asn-X-Ser/Thr(ly)
type: Reaction

metaR PFK26
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (5210.1) or (5207.1) or (5209.1) or (5208.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.105 Confidence Level: 0 AUTHORS: NOTES:IF
is described by: ECO:0000000
reactant: MODEL1310110024#
is: SBO:0000176
type: Reaction
reversible: false
name: 6-phosphofructo-2-kinase
modifier: MODEL1310110024#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.105
product: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_7f69a04a_b102_4cbf_84bf_21c3c4e97d50
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false
name: ACAA1
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:30
is: Q96CA6

metaR PACCOAL
kinetic law: MODEL1310110024#
type: Reaction
name: phenylacetate-CoA ligase
fast: false
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 6.2.1.30 Confidence Level: 2 AUTHORS: NOTES:JLR
reactant: MODEL1310110024#
product: MODEL1310110024#
reversible: false

metaR RE2649C
product: MODEL1310110024#
name: RE2649
kinetic law: MODEL1310110024#
type: Reaction
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.65
is version of: http://identifiers.org/ec-code/3.1.2.2
fast: false
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_eadd20c3_8857_4bbc_94d0_a1b1f81823d7
boundary condition: true
type: Species
is: SBO:0000252
is: O95258
constant: false
is encoded by: hsa:9016
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: SLC25A14

metaR ALR3
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.2
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.1.21
product: MODEL1310110024#
kinetic law: MODEL1310110024#
type: Reaction
name: aldose reductase (acetol)
reactant: MODEL1310110024#
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_a3974c88_6c12_47d3_b580_40e1a6211c5e
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6575
constant: false
name: SLC20A2
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
is: B2RBR4

metaR FAOXTC142TC122m
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C14:2-->C12:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_2c04fbfe_a026_4679_b4d5_844ffc1cba03
is encoded by: hsa:8503
is: SBO:0000297
type: Species
has only substance units: false
has part: A7E2E0
has part: Q92569
boundary condition: true
name: PIK3CD:PIK3R3
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:5293

http://identifiers.org/biomodels.db/MODEL1310110024#_265dca85_2c58_402c_8a44_9e1aabf0e7e5
has part: P48507
has part: E1CEI4
constant: false
is: SBO:0000297
initial amount: NaN
has only substance units: false
is encoded by: hsa:2730
boundary condition: true
type: Species
name: GCLC:GCLM
is encoded by: hsa:2729
initial concentration: NaN

metaM 4hpro LT c
is: SBO:0000247
initial concentration: 1.0
name: trans-4-hydroxy-L-proline
is: HMDB00725
boundary condition: false
initial amount: NaN
is: CHEBI:18095
has only substance units: false
type: Species
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
constant: false

metaM HC00361 c
type: Species
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:58335
boundary condition: false
name: sedoheptulose 1,7-bisphosphate(4-)
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
initial amount: NaN

metaR DITPtn
type: Reaction
is: SBO:0000185
name: dITP nuclear transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110024#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_5678f14e_f869_4f2f_b549_47e5ea467856
boundary condition: true
is: Q9HC58
has only substance units: false
name: SLC24A3
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:57419
type: Species
is: SBO:0000252
constant: false

metaM pap c
boundary condition: false
is: HMDB00061
initial amount: NaN
type: Species
name: adenosine 3',5'-bismonophosphate(4-)
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
is: CHEBI:58343
has only substance units: false

metaR ASPTAm
fast: false
type: Reaction
modifier: MODEL1310110024#
is described by: ECO:0000269
name: aspartate transaminase
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:6930651 NOTES:NCD
reversible: true
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.1

metaR GLUTCOADHm
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.7
is described by: ECO:0000304
product: MODEL1310110024#
fast: false
reversible: false
name: glutaryl-CoA dehydrogenase (mitochondria)
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (2639.1) or (2639.2) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 2 AUTHORS: NOTES:SAB use of FAD is not certain
is: SBO:0000176

metaR COAtp
reversible: true
name: coenzyme A transport, peroxisomal
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110024#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110024#

metaR r2404
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
reversible: false
kinetic law: MODEL1310110024#
fast: false
reactant: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110024#

metaR ALR2
is version of: http://identifiers.org/ec-code/1.1.1.2
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.1.21
type: Reaction
is described by: ECO:0000269
name: aldose reductase (methylglyoxal)
fast: false
product: MODEL1310110024#
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110024#_80a56eef_2010_4c2b_9cef_d8abab02e61e
type: Species
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:1345
boundary condition: true
is: P09669
name: COX6C
initial concentration: NaN
initial amount: NaN

metaR F1PGT
is described by: ECO:0000000
reactant: MODEL1310110024#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (8790.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.30 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.30
name: fucose-1-phosphate guanylyltransferase
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
is: SBO:0000176
product: MODEL1310110024#

metaR MMSAD3m
is: SBO:0000176
kinetic law: MODEL1310110024#
type: Reaction
reactant: MODEL1310110024#
fast: false
product: MODEL1310110024#
name: methylmalonate-semialdehyde dehydrogenase (malonic semialdehyde), mitochondrial
is version of: http://identifiers.org/ec-code/1.2.1.27
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093,PMID:6418146 NOTES:also EC 1.2.1.18 - NCD
modifier: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_f35245db_9392_447f_be60_26d142546dd1
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:3242
is: B3KQ63
type: Species
name: HPD

metaM eicostetcoa m
is: SBO:0000247
constant: false
type: Species
name: eicosatetranoyl coenzyme A
is: C16164
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110024#_ef78f9dd_197e_4428_af33_5b12b48e89ee
is: A8MU28
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
name: NAE1
is encoded by: hsa:8883
initial amount: NaN
initial concentration: NaN
constant: false

metaM tsul c
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:16094
has only substance units: false
name: thiosulfate(2-)
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
type: Species
initial amount: NaN
is: HMDB00257
is: SBO:0000247

metaM 12ppd S c
initial amount: NaN
constant: false
has only substance units: false
is: HMDB06213
name: (S)-propane-1,2-diol
is: CHEBI:29002
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m0/s1
type: Species

metaM ocdcea l
is: HMDB00207
initial amount: NaN
is: CHEBI:30823
constant: false
initial concentration: 1.0
name: oleate
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9- HEPATONET_1.0_ABBREVIATION: HC00510 EHMN_ABBREVIATION: C00712

http://identifiers.org/biomodels.db/MODEL1310110024#_40c40b16_d0b5_4357_a5a0_9e985bdb50dc
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false
name: PDE2A
is: Q8IW54
is encoded by: hsa:5138
initial amount: NaN

metaR r0653
fast: false
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10706581,PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110024#
reactant: MODEL1310110024#
name: myristoyl-CoA:acetylCoA C-myristoyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reversible: false
type: Reaction

metaM 34hpp m
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:36242
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
type: Species
has only substance units: false
is: HMDB00707
initial concentration: 1.0
name: 3-(4-hydroxyphenyl)pyruvate
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110024#_b8b9e4a4_c97d_410d_a3fc_fb0d5dc3f89c
constant: false
type: Species
has only substance units: false
initial amount: NaN
name: MTR
is encoded by: hsa:4548
is: Q99707
boundary condition: true
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_29dc3b7d_5d34_4a78_a8b2_3433e03c9a1d
constant: false
name: ABAT
is encoded by: hsa:18
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN

metaM dtmp m
name: dTMP
boundary condition: false
constant: false
is: CHEBI:26999
is: C00364
is: HMDB01227
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364

metaM ksii core2 pre8 g
is: SBO:0000247
notes: FORMULA: C75H121N6O56SX CHARGE: -2
type: Species
constant: false
is: C00130
initial amount: NaN
has only substance units: false
is: CHEBI:58053
name: keratan sulfate II biosynthesis, precursor 8
is: HMDB00175
boundary condition: false
initial concentration: 1.0

metaM cmpacna g
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
constant: false
is: CHEBI:57812
initial amount: NaN
name: CMP-N-acetyl-beta-neuraminate(2-)
is: SBO:0000247
is: HMDB01176
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0

metaR FAOXC101m
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)m
type: Reaction

metaR r0652
is: SBO:0000176
name: trans-Tetradec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
modifier: MODEL1310110024#
reversible: true
type: Reaction
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.2
reactant: MODEL1310110024#
fast: false
kinetic law: MODEL1310110024#
is described by: ECO:0000000

metaR COAtr
kinetic law: MODEL1310110024#
name: COA transporter, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
fast: false
is: SBO:0000185
reactant: MODEL1310110024#
type: Reaction
product: MODEL1310110024#
is described by: ECO:0000000
reversible: true

metaR r0246
fast: false
modifier: MODEL1310110024#
reactant: MODEL1310110024#
type: Reaction
kinetic law: MODEL1310110024#
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
is: SBO:0000176
reversible: false
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.5.1.3
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

metaM doco13ac e
name: docosenoic acid (C22:1)
has only substance units: false
notes: FORMULA: C22H41O2 CHARGE: -1
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
is: HMDB02068
boundary condition: false
initial concentration: 1.0

metaM ptth m
is: HMDB03426
constant: false
name: pantetheine
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
type: Species
has only substance units: false
is: CHEBI:16753
is: SBO:0000247
boundary condition: false

metaR r2401
reversible: false
kinetic law: MODEL1310110024#
type: Reaction
product: MODEL1310110024#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

http://identifiers.org/biomodels.db/MODEL1310110024#_e2b459c1_002c_459c_a9fd_6df065c73bba
has only substance units: false
is encoded by: hsa:5805
type: Species
constant: false
name: PTS
boundary condition: true
is: Q03393
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaR r0651
reactant: MODEL1310110024#
fast: false
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.2
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
product: MODEL1310110024#
is described by: ECO:0000000
modifier: MODEL1310110024#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110024#

metaM acgam6p c
name: N-acetyl-D-glucosamine 6-phosphate(2-)
initial amount: NaN
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
boundary condition: false
is: HMDB01062
constant: false
is: SBO:0000247
is: CHEBI:57513
type: Species
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110024#_9c8f4624_9480_4bf1_92d9_f05fe62d6cc9
name: _BE966236_1_m
has only substance units: false
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:BE966236
initial concentration: NaN
boundary condition: true

metaR DMHPTCRNte
reactant: MODEL1310110024#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110024#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:unknown mechanism for transport -see PMID 9299016, identifies 2,6-dimethylheptanoyl carnitine in the urine! NJ
type: Reaction
name: 2,6 dimethylheptanoyl carnitine transport
product: MODEL1310110024#
is: SBO:0000185

metaM tsul e
constant: false
is: CHEBI:16094
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB00257
is: SBO:0000247
type: Species
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
name: thiosulfate(2-)

metaM ak2lgchol hs e
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/6975
constant: false
initial concentration: 1.0
is: C04317
name: 1-alkyl 2-lysoglycerol 3-phosphocholine

http://identifiers.org/biomodels.db/MODEL1310110024#_917de33d_e830_47b0_a3a0_5bdf63eec518
has only substance units: false
constant: false
name: AKR1C4
type: Species
is: SBO:0000252
initial concentration: NaN
is: P17516
initial amount: NaN
is encoded by: hsa:1109
boundary condition: true

metaR r0245
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
product: MODEL1310110024#
modifier: MODEL1310110024#
type: Reaction
is: SBO:0000176
reversible: true
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
fast: false
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.5.1.3
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110024#_3bbb1e02_701b_4ad2_8a86_cd93143d016a
boundary condition: true
has only substance units: false
name: CDO1
constant: false
initial concentration: NaN
is: SBO:0000252
is: Q16878
initial amount: NaN
is encoded by: hsa:1036
type: Species

metaR RE2677E
name: RE2677
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:IT - fixed proton
kinetic law: MODEL1310110024#
type: Reaction
fast: false
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110024#
is: SBO:0000176
product: MODEL1310110024#

metaM g3m8mpdol U r
initial amount: NaN
type: Species
notes: FORMULA: C1905H3140N20O770P20 CHARGE: -20
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: C05873
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaR DNDPt8m
fast: false
is described by: ECO:0000269
is: SBO:0000185
name: dADP transport via dUDP antiport
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110024#
type: Reaction
reversible: false
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#

metaM ksi pre2 g
initial concentration: 1.0
notes: FORMULA: C87H142N6O62X CHARGE: -1
initial amount: NaN
is: HMDB00175
is: C00130
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 2
type: Species
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:58053

http://identifiers.org/biomodels.db/MODEL1310110024#_87d02045_a84c_46d8_8214_e7d74edd4ce6
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
name: KHK
is encoded by: hsa:3795
boundary condition: true
is: SBO:0000252
is: P50053

metaR r1782
type: Reaction
name: Y+LAT2 Utilized transport
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110024#
is: SBO:0000185
reversible: false
modifier: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000000

metaM 4hbz m
is: CHEBI:17879
is: HMDB00500
has only substance units: false
notes: FORMULA: C7H5O3 CHARGE: -1 INCHI: InChI=1S/C7H6O3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H,(H,9,10)/p-1
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
name: 4-hydroxybenzoate
boundary condition: false

metaR EX retinol 9 cis LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 9-cis-retinol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_d914829d_7e6a_43b9_8123_09c09d0f8ff2
boundary condition: true
is: P48651
is encoded by: hsa:9791
name: PTDSS1
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_5077a113_4875_41ca_9ba7_c558c37d3cb0
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:290
boundary condition: true
constant: false
initial concentration: NaN
name: ANPEP
is: Q59E93

metaM 1p3h5c m
is: HMDB01369
has only substance units: false
initial concentration: 1.0
type: Species
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
initial amount: NaN
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
is: CHEBI:6151
constant: false
is: SBO:0000247
boundary condition: false

metaR r1607
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
product: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110024#
is: SBO:0000185
kinetic law: MODEL1310110024#
fast: false

metaR CYTD
notes: GENE_ASSOCIATION: (978.1) or (57379.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.5 Confidence Level: 2 AUTHORS: PMID:14744791,PMID:15087440,PMID:7923172,PMID:8001985,PMID:8422236 NOTES:
is version of: http://identifiers.org/ec-code/3.5.4.5
reactant: MODEL1310110024#
name: cytidine deaminase
type: Reaction
kinetic law: MODEL1310110024#
is described by: ECO:0000254
is: SBO:0000176
product: MODEL1310110024#
modifier: MODEL1310110024#
reversible: false
fast: false

metaR APOCF
is: SBO:0000176
product: MODEL1310110024#
fast: false
name: Apocarboxylase formation
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10191093 NOTES:IT faked reaction to balance reaction in human biotin metabolism
is described by: ECO:0000000
type: Reaction
reversible: false
kinetic law: MODEL1310110024#

metaR S23T2g
reactant: MODEL1310110024#
name: beta-galactoside alpha-2,3-sialyltransferase (core 2)
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
is described by: ECO:0000000
modifier: MODEL1310110024#
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.4.99.4
kinetic law: MODEL1310110024#
is: SBO:0000176

metaR r1783
reactant: MODEL1310110024#
is described by: ECO:0000000
product: MODEL1310110024#
type: Reaction
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110024#_6df78ebf_3f91_48b7_ace5_77cda52b09f7
is: Q16853
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
constant: false
name: AOC3
has only substance units: false
is encoded by: hsa:8639

http://identifiers.org/biomodels.db/MODEL1310110024#_8c8b9ea1_f0b7_4a1c_88fa_321da56b6273
is: B7Z428
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: GNE
is: SBO:0000252
is encoded by: hsa:10020
boundary condition: true

metaR RE1527M
is: SBO:0000176
type: Reaction
modifier: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110024#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110024#
name: RE1527
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:

metaR r1608
is: SBO:0000185
reversible: true
fast: false
kinetic law: MODEL1310110024#
is described by: ECO:0000000
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_2f3d0dff_151d_4ac6_9e28_89df24e52a64
name: CA7
initial amount: NaN
type: Species
has only substance units: false
is: P43166
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:766

metaR NACHEX11ly
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110024#
type: Reaction
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000000
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

metaR DOLASNT Ler
kinetic law: MODEL1310110024#
type: Reaction
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (6185.1 and 1650.1 and 6184.1 and 1603.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.119 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.4.1.119
name: Dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase (liver)
reversible: false
is described by: ECO:0000000
is: SBO:0000176
fast: false
modifier: MODEL1310110024#

metaM dd3coa x
constant: false
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB04257
initial amount: NaN
name: 3-dodecenoylcoa
initial concentration: 1.0
notes: FORMULA: C33H52N7O17P3S CHARGE: -4

metaM ksii core2 pre6 g
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C61H98N5O46SX CHARGE: -2
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
name: keratan sulfate II biosynthesis, precursor 6
is: CHEBI:28067

metaR MAOX
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:11136547,PMID:14715500,PMID:9131641 NOTES:SAB
is described by: ECO:0000304
kinetic law: MODEL1310110024#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.21
name: Methylamine oxidase
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.4.3.22
reversible: false
type: Reaction
modifier: MODEL1310110024#
reactant: MODEL1310110024#

metaR UGLT
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110024#
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
name: UDPglucose--hexose-1-phosphate uridylyltransferase
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:12923184 NOTES:NCD
fast: false
reversible: true
modifier: MODEL1310110024#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.12

http://identifiers.org/biomodels.db/MODEL1310110024#_3ec60566_982c_4780_8bcd_6e67cc267c06
has only substance units: false
is: O14521
is: SBO:0000252
name: SDHD
initial concentration: NaN
boundary condition: true
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:6392

metaR GLUCYS
product: MODEL1310110024#
reversible: false
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110024#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2729.1) and (2730.1) SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/6.3.2.2
name: Gamma-glutamylcysteine synthetase
modifier: MODEL1310110024#
fast: false

metaM 34hpp c
has only substance units: false
constant: false
boundary condition: false
name: 3-(4-hydroxyphenyl)pyruvate
is: HMDB00707
initial concentration: 1.0
is: CHEBI:36242
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
type: Species
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_85835ec6_3d32_440b_80b4_a177e9260eb1
type: Species
initial concentration: NaN
is: Q9Y5L3
initial amount: NaN
is encoded by: hsa:954
is: SBO:0000252
name: ENTPD2
constant: false
has only substance units: false
boundary condition: true

metaR r1609
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110024#
product: MODEL1310110024#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110024#
is described by: ECO:0000000

metaR TRDRm
is: SBO:0000176
reactant: MODEL1310110024#
type: Reaction
fast: false
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
name: thioredoxin reductase (NADPH)
is version of: http://identifiers.org/ec-code/1.8.1.9
notes: GENE_ASSOCIATION: (114112.1) or (10587.1) or (10587.3) or (10587.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:10215850,PMID:11259642,PMID:12705894 NOTES:NCD
product: MODEL1310110024#

metaR TYRTA
is version of: http://identifiers.org/ec-code/2.6.1.1
modifier: MODEL1310110024#
reversible: true
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110024#
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
name: tyrosine transaminase
type: Reaction

metaR PROt4 2 r
product: MODEL1310110024#
name: Proline transport (sodium symport) (2:1)
reactant: MODEL1310110024#
type: Reaction
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is described by: ECO:0000006
is: SBO:0000185
reversible: true
modifier: MODEL1310110024#
fast: false

metaM glygn5 e
type: Species
has only substance units: false
boundary condition: false
is: HMDB06372
notes: FORMULA: C12H21O11X CHARGE: 0
name: glycogen, structure 5 (glycogenin-2[1,4-Glc])
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:33871
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_6a88ca6e_c442_466d_9255_39fe72883aec
name: AHCYL1
is: SBO:0000252
type: Species
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:10768

http://identifiers.org/biomodels.db/MODEL1310110024#_2a087816_4a43_4865_b39d_81d25d3abdbd
initial amount: NaN
constant: false
is encoded by: hsa:7357
has only substance units: false
is: SBO:0000252
boundary condition: true
is: Q16739
type: Species
initial concentration: NaN
name: UGCG

metaM 4hpro LT m
initial amount: NaN
name: trans-4-hydroxy-L-proline
has only substance units: false
is: HMDB00725
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
is: CHEBI:18095
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247

metaR XYLTD Dr
product: MODEL1310110024#
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
name: xylitol dehydrogenase (D-xyulose-forming)
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.9 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110024#_9c55ffa1_ecb8_4fc9_89af_e81a4806f226
has only substance units: false
initial amount: NaN
name: PIGF
is encoded by: hsa:5281
constant: false
type: Species
is: Q6IB04
is: SBO:0000252
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110024#_da59fc4b_ace9_4127_82bf_c03d58f37298
is encoded by: hsa:6520
constant: false
type: Species
has only substance units: false
name: SLC3A2
initial amount: NaN
initial concentration: NaN
is: P08195
is: SBO:0000252
boundary condition: true

metaR r0655
modifier: MODEL1310110024#
reactant: MODEL1310110024#
reversible: true
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.5.1.2
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
product: MODEL1310110024#

metaM pppg9 c
has only substance units: false
constant: false
is: CHEBI:57307
initial amount: NaN
is: HMDB01097
type: Species
is: C01079
boundary condition: false
notes: FORMULA: C34H38N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00656 EHMN_ABBREVIATION: C01079
initial concentration: 1.0
name: Protoporphyrinogen IX
is: SBO:0000247

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_5219d5f8_11cc_4fd7_9ba5_c4ea46fb6636
has only substance units: false
is encoded by: hsa:57171
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
name: DOLPP1
constant: false
is: Q86YN1

http://identifiers.org/biomodels.db/MODEL1310110024#_9280dcea_e0fb_4daa_9ffe_f64e3dd5ac1c
is encoded by: hsa:10317
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: B3GALT5

metaR C4STMO1r
modifier: MODEL1310110024#
reversible: false
is version of: http://identifiers.org/ec-code/1.14.13.72
name: C-4 sterol methyl oxidase (4,4-dimethylzymosterol)
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
product: MODEL1310110024#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6307.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:EC 1.-.-.- NCD ER version NJ

http://identifiers.org/biomodels.db/MODEL1310110024#_93160229_afd0_49d1_9e1d_af3245c8d70d
initial concentration: NaN
name: NME2
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:4831
has only substance units: false
type: Species
constant: false
is: P22392

metaR DOLGLCP Uter
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
type: Reaction
reactant: MODEL1310110024#
product: MODEL1310110024#
fast: false
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110024#
name: Dolichyl beta-D-glucosyl phosphate flippase (uterus)

metaR URIK1
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.48 Confidence Level: 4 AUTHORS: PMID:11306702,PMID:12199906,PMID:8812458 NOTES:
name: uridine kinase (ATP:Uridine)
kinetic law: MODEL1310110024#
type: Reaction
is described by: ECO:0000269
fast: false
reversible: false
modifier: MODEL1310110024#
is: SBO:0000176
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.7.1.48

metaM dtmp c
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
has only substance units: false
is: CHEBI:26999
initial concentration: 1.0
type: Species
name: dTMP
is: C00364
initial amount: NaN
is: HMDB01227
is: SBO:0000247
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_94840a13_c65a_45b2_b7d5_667954df3785
is encoded by: hsa:8818
initial concentration: NaN
is: SBO:0000252
name: DPM2
type: Species
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN

metaM 34hpp e
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:36242
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
is: HMDB00707
boundary condition: false
is: SBO:0000247
name: 3-(4-hydroxyphenyl)pyruvate
constant: false
initial amount: NaN

metaR 3MOBte
reactant: MODEL1310110024#
name: Transport of 3-methyl-2-oxobutanoate
kinetic law: MODEL1310110024#
reversible: true
product: MODEL1310110024#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_d8df9df9_5649_4d99_b395_8a448587f730
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: PRODH
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:5625
is: O43272

metaR GGH 6DHFe
modifier: MODEL1310110024#
reversible: false
reactant: MODEL1310110024#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
fast: false
is version of: http://identifiers.org/ec-code/3.4.19.9
kinetic law: MODEL1310110024#
is described by: ECO:0000000
product: MODEL1310110024#
name: Gamma-glutamyl hydrolase (6DHF), extracellular

metaR EX ksi LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I exchange
type: Reaction

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

metaR FAOXC122x
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)x
type: Reaction

metaR EX for LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Formate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_66c5b908_7c70_4fdb_a170_42446fefff5a
is: SBO:0000252
constant: false
is encoded by: hsa:84720
boundary condition: true
is: Q8TEQ8
initial amount: NaN
has only substance units: false
name: PIGO
type: Species
initial concentration: NaN

metaR LCADi D
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.36
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110024#
name: lactaldehyde dehydrogenase
reversible: false
is described by: ECO:0000304

metaM ocdcea c
has only substance units: false
initial amount: NaN
is: C00712
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C18H33O2 CHARGE: -1
is: CHEBI:0
is: HMDB00207
boundary condition: false
is: SBO:0000247
name: octadecenoate (n-C18:1)

http://identifiers.org/biomodels.db/MODEL1310110024#_62e5fd75_51fc_4731_9b87_c474fa06c68a
name: NIT2
type: Species
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:56954
is: SBO:0000252
is: Q9NQR4

http://identifiers.org/biomodels.db/MODEL1310110024#_3ac0515e_4056_4284_a37d_3293fbaa33eb
initial concentration: NaN
name: ATP1A1:ATP1B3
has only substance units: false
type: Species
is encoded by: hsa:483
is encoded by: hsa:476
constant: false
is: SBO:0000297
has part: P54709
initial amount: NaN
boundary condition: true
has part: B7Z3U6

metaR GUMGCHLe
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Binding of guar gums with glycocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_784db60f_cde2_4241_9067_0d4cc584c248
is: SBO:0000252
name: RHBG
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:57127
is: Q9H310
boundary condition: true
initial amount: NaN

metaM 13dpg c
type: Species
has only substance units: false
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
initial amount: NaN
is: CHEBI:57604
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/3535
name: 3-Phospho-D-glyceroyl phosphate
is: HMDB01270
is: C00236
initial concentration: 1.0
is: SBO:0000247

metaR ABUTt2r
modifier: MODEL1310110024#
name: 4-aminobutyrate reversible transport in via proton symport
is: SBO:0000185
fast: false
reversible: true
is described by: ECO:0000304
reactant: MODEL1310110024#
type: Reaction
kinetic law: MODEL1310110024#
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r

metaR UMPK7n
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110024#
type: Reaction
fast: false
is described by: ECO:0000269
is: SBO:0000176
name: UMP kinase (dGTP),nuclear
reversible: true
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110024#

metaR RE2677C
type: Reaction
kinetic law: MODEL1310110024#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110024#
reversible: false
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:
is: SBO:0000176
name: RE2677

metaM 4hphac c
is: CHEBI:48999
type: Species
constant: false
is: HMDB00020
boundary condition: false
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: 4-hydroxyphenylacetate

http://identifiers.org/biomodels.db/MODEL1310110024#_6f14bc45_2984_4a5f_adc2_09b4fca61926
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaR G14T7g
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
product: MODEL1310110024#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8704.1) or (8703.1) or (2683.1) or (9334.1) or (8704.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
modifier: MODEL1310110024#

metaR HPYRR2x
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
is: SBO:0000176
name: hydroxypyruvate reductase (NADH)
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.1.1.27
notes: GENE_ASSOCIATION: (3948.1) or (197257.1) or (3945.1) or (160287.1) or (3945.1 and 3939.1) or (92483.1) or (3939.1) or (197257.2) or (3948.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:14635115,PMID:5635456 NOTES:NCD
type: Reaction
reactant: MODEL1310110024#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.2.4
fast: false
product: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_dbc3742e_88ea_4076_a335_724da8ea08a4
is: O95168
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
name: NDUFB4
is encoded by: hsa:4710
boundary condition: true

metaM dtmp e
is: CHEBI:26999
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB01227
has only substance units: false
name: dTMP(2-)
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
is: SBO:0000247
constant: false
boundary condition: false

metaR CITL
is described by: ECO:0000000
product: MODEL1310110024#
reactant: MODEL1310110024#
fast: false
reversible: false
type: Reaction
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
is: SBO:0000176
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
name: Citrate lyase

http://identifiers.org/biomodels.db/MODEL1310110024#_8c8208e4_296c_4833_8821_9bae659cc0d5
constant: false
initial concentration: NaN
is: SBO:0000252
name: _D87002_1_e
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:D87002

metaM 3snpyr m
is: HMDB02332
is: CHEBI:1665
notes: FORMULA: C3H2O5S CHARGE: -2 INCHI: InChI=1S/C3H4O5S/c4-2(3(5)6)1-9(7)8/h1H2,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C05527
name: 3-Sulfinopyruvate
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110024#_7d46c4da_d17c_4db5_aaf2_e7aa9c53207d
constant: false
name: UCK2
initial concentration: NaN
is: Q9BZX2
is encoded by: hsa:7371
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaM tsul m
is: SBO:0000247
initial concentration: 1.0
name: thiosulfate(2-)
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
is: HMDB00257
is: CHEBI:16094
boundary condition: false
constant: false

metaM cdpdag hs m
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
constant: false
is: CHEBI:58332
is: SBO:0000247
boundary condition: false
has only substance units: false
name: CDP-diacylglycerol(2-)
initial concentration: 1.0
type: Species
initial amount: NaN

metaR ACACt2
kinetic law: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
is described by: ECO:0000269
name: acetoacetate transport via proton symport
reactant: MODEL1310110024#
is: SBO:0000185
modifier: MODEL1310110024#

metaM c8dc x
notes: FORMULA: C15H26NO6 CHARGE: -1
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB00893
constant: false
name: suberyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110024#_1a021a1f_634c_466d_b490_4d4f93389b27
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is: Q14376
initial amount: NaN
name: GALE
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2582

metaM tmndnccrn c
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C27H43NO4 CHARGE: 0 INCHI: InChI=1/C28H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-28(32)33-26(24-27(30)31)25-29(2,3)4/h6-7,9-10,12-13,15-16,18-19,26H,5,8,11,14,17,20-25H2,1-4H3/t26-/m0/s1
is: SBO:0000247
has only substance units: false
name: Timnodonyl carnitine
is: CHEBI:0
is: C00378
is: HMDB00235
constant: false

metaR C2tcx
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of acetylcarnitine from peroxisomes to cytosol
type: Reaction

metaM didp c
type: Species
is: HMDB03536
is: CHEBI:28823
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
initial concentration: 1.0
name: dIDP
constant: false
has only substance units: false

metaM cmpacna n
is: SBO:0000247
is: HMDB01176
is: CHEBI:57812
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
name: CMP-N-acetyl-beta-neuraminate(2-)
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
type: Species
boundary condition: false

metaR FATP6t
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
reactant: MODEL1310110024#
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110024#
product: MODEL1310110024#
name: fatty acid electroneutral transport
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/6.2.1.7

metaR GPIMTer U
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: (93183.1) and (54965.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11226175,PMID:15635094 NOTES:NCD
fast: false
modifier: MODEL1310110024#
is described by: ECO:0000000
reversible: false
is: SBO:0000176
name: GlcN-acylPI mannosyltransferase, endoplasmic reticulum

http://identifiers.org/biomodels.db/MODEL1310110024#_37df3744_14db_4c76_8113_8ec91b069cc9
initial concentration: NaN
is encoded by: hsa:8706
constant: false
initial amount: NaN
type: Species
name: B3GALNT1
is: SBO:0000252
is: O75752
has only substance units: false
boundary condition: true

metaR PI5P3K
is version of: http://identifiers.org/ec-code/2.7.1.154
is version of: http://identifiers.org/ec-code/2.7.11.1
modifier: MODEL1310110024#
name: phosphatidylinositol-5-phosphate 3-kinase
reactant: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.137
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5295.2 and 5290.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.1) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5290.1 and 5295.3) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.153
fast: false
is described by: ECO:0000000

metaR r1600
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110024#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110024#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110024#

metaR ELAIDCRNt
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110024#
product: MODEL1310110024#
name: transport into the mitochondria (carnitine)
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
modifier: MODEL1310110024#
reactant: MODEL1310110024#
type: Reaction

metaR FAOXC123m
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)m
type: Reaction

metaM hs deg23 l
is: SBO:0000247
constant: false
name: GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
initial amount: NaN
type: Species
notes: FORMULA: C31H49NO29S CHARGE: -2
boundary condition: false
has only substance units: false
is: HMDB02704
is: CHEBI:21338
initial concentration: 1.0

metaR DMHPTCRNt
reversible: true
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 1 AUTHORS: NOTES:dmhptcoa is 'special' because its biochemical fat isn't known NJ
reactant: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
name: 2,6 dimethylheptanoyl crn transport
is described by: ECO:0000000
kinetic law: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_edc3eb21_273f_4372_b722_8733f76593a2
is encoded by: hsa:412
boundary condition: true
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: STS
is: P08842

metaR SPMTDe
is described by: ECO:0000134
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
product: MODEL1310110024#
type: Reaction
name: SPMTDe
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110024#

metaM CE2433 m
initial amount: NaN
initial concentration: 1.0
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
type: Species
has only substance units: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:57795

metaR r1487
is described by: ECO:0000000
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reactant: MODEL1310110024#
fast: false
name: EC:6.2.1.3
kinetic law: MODEL1310110024#
product: MODEL1310110024#
type: Reaction

metaM 7dhf e
is: HMDB06559
name: heptaglutamyl folate (DHF)
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110024#_843e6320_095e_4a07_9a03_857dc746bbf2
initial concentration: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
has only substance units: false
is: SBO:0000297
initial amount: NaN
type: Species
boundary condition: true
constant: false
has part: P48201
is encoded by: hsa:518

metaR FAOXTC162TC142m
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C16:2-->C14:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_2ef72b5d_cc2d_4642_93d9_2de645194b80
is encoded by: hsa:5150
constant: false
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
name: PDE7A
is: Q13946
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110024#_c82b0c84_6ef6_4e3f_bc87_977f5a8ce546
constant: false
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
name: FDPS
is: SBO:0000252
is: P14324
initial concentration: NaN
is encoded by: hsa:2224

metaM hexdpencoa x
is: HMDB02288
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
name: 2,4,7,10,13-hexadecapentaenoylcoa
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C37H52N7O17P3S CHARGE: -4

metaR r1602
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110024#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110024#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaM 3uib c
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H9N2O3 CHARGE: -1 INCHI: InChI=1S/C5H10N2O3/c1-3(4(8)9)2-7-5(6)10/h3H,2H2,1H3,(H,8,9)(H3,6,7,10) HEPATONET_1.0_ABBREVIATION: HC01371 EHMN_ABBREVIATION: C05100
boundary condition: false
constant: false
name: 3-Ureidoisobutyrate
is: HMDB02031
is: CHEBI:1670
initial concentration: 1.0
type: Species
is: SBO:0000247

metaM ser L c
is: HMDB00187
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
boundary condition: false
initial amount: NaN
name: L-serine
type: Species
is: CHEBI:17115

metaR RE3242R
product: MODEL1310110024#
reversible: true
fast: false
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is: SBO:0000176
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
modifier: MODEL1310110024#
is described by: ECO:0000000
name: RE3242
type: Reaction

metaR PYDXNK
type: Reaction
product: MODEL1310110024#
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.7.1.35
fast: false
notes: GENE_ASSOCIATION: (8566.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110024#
is described by: ECO:0000269
modifier: MODEL1310110024#
reversible: false
name: pyridoxine kinase
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110024#_b96338eb_5fb1_428c_8033_b91890888ad1
boundary condition: true
is encoded by: hsa:498
constant: false
initial concentration: NaN
is encoded by: hsa:509
is: SBO:0000297
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
has part: P25705
has part: Q6I9V2
initial amount: NaN
type: Species
has only substance units: false

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

metaM acac e
is: HMDB00060
name: acetoacetate
type: Species
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: CHEBI:13705
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false

metaR r1776
modifier: MODEL1310110024#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110024#
reversible: false
fast: false
is: SBO:0000185
kinetic law: MODEL1310110024#
type: Reaction
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR RE0830N
reactant: MODEL1310110024#
name: RE0830
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/4.2.1.96
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110024#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_9580ae5a_283a_49f5_8085_126b835d2e6f
is encoded by: hsa:7296
initial concentration: NaN
name: TXNRD1
type: Species
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR EX CE1936 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: spermine dialdehyde exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_22f466f1_5635_40d4_8c88_5e5c8db60f20
type: Species
is encoded by: hsa:AI697028
constant: false
initial amount: NaN
name: _AI697028_1_e
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110024#_c9d35680_1f1c_4625_aa3a_34da4a80447c
has only substance units: false
name: FASN
constant: false
initial amount: NaN
is: P49327
is: SBO:0000252
type: Species
is encoded by: hsa:2194
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110024#_c761350a_bdc1_4e90_a461_fc8d831d6f2e
has only substance units: false
initial amount: NaN
name: PDE4A
initial concentration: NaN
is: P27815
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5141
constant: false
type: Species

metaR ACNAMPH
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 3.1.3.29 Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
type: Reaction
product: MODEL1310110024#
name: N-Acetylneuraminate 9-phosphate phosphohydrolase

metaM leuktrC4 c
is: SBO:0000247
is: HMDB01198
name: leukotriene C4(2-)
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:57973
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166

http://identifiers.org/biomodels.db/MODEL1310110024#_138e4f15_063d_4ced_853f_1f8007002003
is encoded by: hsa:159963
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
is: Q1EHB4
boundary condition: true
has only substance units: false
name: SLC5A12

http://identifiers.org/biomodels.db/MODEL1310110024#_d12bb7c7_73e0_4fdc_a0bf_41478b2781a6
initial amount: NaN
type: Species
is encoded by: hsa:23236
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: PLCB1
constant: false

metaR S6T1g
reactant: MODEL1310110024#
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is described by: ECO:0000000
kinetic law: MODEL1310110024#
product: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
modifier: MODEL1310110024#
type: Reaction
reversible: false

metaR r1604
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110024#

metaM mlthf c
name: 5,10-Methylenetetrahydrofolate
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB01533
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
constant: false
is: SBO:0000247
is: CHEBI:15636
boundary condition: false
initial amount: NaN
is: C00143

http://identifiers.org/biomodels.db/MODEL1310110024#_f8ed5a58_1508_46d1_ac37_4f3f4377a93b
boundary condition: true
constant: false
type: Species
is: P19440
initial concentration: NaN
is encoded by: hsa:2678
has only substance units: false
name: GGT1
is: SBO:0000252
initial amount: NaN

metaR r1775
fast: false
is: SBO:0000185
reversible: false
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110024#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_c506dd59_b354_4e5f_9359_ff2b1f1048f0
is encoded by: hsa:2519
name: FUCA2
type: Species
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
is: Q9BTY2
has only substance units: false
initial concentration: NaN

metaR EX leuktrC4 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leukotriene C4 exchange
type: Reaction

metaR RE0935E
name: RE0935
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.1
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000000
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.2.1.17
fast: false
modifier: MODEL1310110024#

metaR r1603
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110024#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
fast: false
reversible: true
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_d87626d1_1693_4bf4_86ad_7dca0ba61e97
type: Species
constant: false
name: CBS
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:875
is: Q9NTF0

metaM acac c
has only substance units: false
boundary condition: false
name: acetoacetate
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB00060
is: CHEBI:13705
constant: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
initial amount: NaN

metaR TAUPAT1c
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of taurine into the intestinal cells by PAT1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_7b8daadc_8d09_48a6_b80b_4b6f81130eef
initial amount: NaN
initial concentration: NaN
is: Q8NFL0
boundary condition: true
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:93010
name: B3GNT7
has only substance units: false

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_6d5f4abb_4e4c_4766_9592_d01a0227fb3f
is encoded by: hsa:9963
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
name: SLC23A1
has only substance units: false
type: Species
initial amount: NaN

metaR EX c4dc
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for succinyl carnitine
type: Reaction

metaR CHATn
is described by: ECO:0000269
is: SBO:0000176
reversible: true
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.3.1.6
product: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
reactant: MODEL1310110024#
type: Reaction
kinetic law: MODEL1310110024#
name: Choline O-acetyltransferase

http://identifiers.org/biomodels.db/MODEL1310110024#_72f647ab_8726_4ed5_9ce1_90ed50d305f0
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: ACHE
is: SBO:0000252
type: Species
is encoded by: hsa:43

metaM 12ppd R c
is: HMDB01881
name: (R)-propane-1,2-diol
boundary condition: false
constant: false
is: CHEBI:28972
type: Species
initial concentration: 1.0
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m1/s1
is: SBO:0000247
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_f631bf39_3fc3_4aaf_abc4_310e36d3574e
boundary condition: true
is encoded by: hsa:39
is: Q9BWD1
is: SBO:0000252
constant: false
type: Species
name: ACAT2
has only substance units: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_acb4426f_cf8e_47a4_bc0a_5f958e5ada91
constant: false
type: Species
name: NMNAT3
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:349565
boundary condition: true
is: Q96T66
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_772523ad_5c35_4c86_9685_1cbaf03935d8
is encoded by: hsa:122481
boundary condition: true
constant: false
initial amount: NaN
is: Q96M32
name: AK7
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species

metaR r1606
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110024#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110024#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110024#_99d4bbf8_4ce7_4e08_9d6b_5766c86f0f51
boundary condition: true
name: FADS2
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
is: O95864
has only substance units: false
is encoded by: hsa:9415
initial amount: NaN

metaR CSm
is version of: http://identifiers.org/ec-code/2.3.3.1
reactant: MODEL1310110024#
modifier: MODEL1310110024#
is described by: ECO:0000134
name: citrate synthase
kinetic law: MODEL1310110024#
is: SBO:0000176
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (1431.1) or (1431.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.7 Confidence Level: 0 AUTHORS: PMID:16006620,PMID:9933076 NOTES:IF old EC number (4.1.3.7) is obsolete -- transferred to 2.3.3.1 NCD. Biochemical
fast: false
type: Reaction
reversible: false

metaR FAOXC185m
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:5)m
type: Reaction

metaM hs deg20 l
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
name: heparan sulfate, degradation product 20
type: Species
is: CHEBI:16126
constant: false

metaM ksi deg22 l
name: keratan sulfate I, degradation product 22
type: Species
has only substance units: false
is: CHEBI:57455
notes: FORMULA: C132H214N9O111S5 CHARGE: -5
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB01354
boundary condition: false

metaM 3mox4hpac m
boundary condition: false
name: (4-hydroxy-3-methoxyphenyl)acetaldehyde
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H10O3 CHARGE: 0 INCHI: InChI=1S/C9H10O3/c1-12-9-6-7(4-5-10)2-3-8(9)11/h2-3,5-6,11H,4H2,1H3 HEPATONET_1.0_ABBREVIATION: HC01518 EHMN_ABBREVIATION: C05581
is: CHEBI:28111
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB05175
type: Species

metaR CYTK3n
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110024#
product: MODEL1310110024#
modifier: MODEL1310110024#
is: SBO:0000176
reversible: true
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP,CTP),nuclear
is described by: ECO:0000269

metaM cspg b l
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
is: HMDB02183
is: CHEBI:36005

metaR r1773
reversible: false
reactant: MODEL1310110024#
fast: false
kinetic law: MODEL1310110024#
name: Y+LAT2 Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110024#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110024#

metaM 2mop m
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB01172
initial amount: NaN
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
type: Species
name: 2-methyl-3-oxopropanoate
is: CHEBI:57700

metaR FUM
modifier: MODEL1310110024#
is: SBO:0000176
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: NOTES:
fast: false
product: MODEL1310110024#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110024#
name: fumarase
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.2

metaR GCC2am
is described by: ECO:0000269
product: MODEL1310110024#
reversible: true
is version of: http://identifiers.org/ec-code/2.1.2.10
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.8.1.4
name: glycine-cleavage complex (lipoamide), mitochondrial
kinetic law: MODEL1310110024#
fast: false
is version of: http://identifiers.org/ec-code/1.4.4.2
reactant: MODEL1310110024#
is: SBO:0000176
modifier: MODEL1310110024#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_6d20d1da_9393_480a_8e09_c5479694b857
initial amount: NaN
name: ST3GAL3
is encoded by: hsa:6487
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110024#_bf1d3a41_4fbc_48d7_8f2d_80f7f018a568
name: TXNRD2
initial amount: NaN
is: Q9NNW7
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:10587
constant: false
boundary condition: true

metaM ksi deg6 l
has only substance units: false
name: keratan sulfate I, degradation product 6
is: SBO:0000247
is: CHEBI:12936
boundary condition: false
is: HMDB00143
notes: FORMULA: C210H336N15O184S11 CHARGE: -11
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0

metaR r1605
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
product: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_63331d35_8c67_46ed_9e64_fc1bd05360fc
name: PANK1
is encoded by: hsa:53354
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
constant: false
boundary condition: true
initial amount: NaN

metaR AKGtp
name: AKG transporter, peroxisome
is described by: ECO:0000000
product: MODEL1310110024#
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
reversible: true

metaR LPS3e
type: Reaction
product: MODEL1310110024#
reversible: false
name: lipase, extracellular
fast: false
is version of: http://identifiers.org/ec-code/3.1.1.3
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.23 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:NJ
is: SBO:0000176
modifier: MODEL1310110024#
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_121b0680_f5e9_4c14_a2f4_0b1729cdea2a
boundary condition: true
initial concentration: NaN
type: Species
name: _PRO1933_1_m
has only substance units: false
initial amount: NaN
is encoded by: hsa:PRO1933
constant: false
is: SBO:0000252

metaR C180CRNt
is: SBO:0000185
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110024#
product: MODEL1310110024#
modifier: MODEL1310110024#
name: C180 transport into the mitochondria
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
type: Reaction
fast: false

metaR SUBERCROT
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberyl carnitine
type: Reaction

metaM leu L m
constant: false
boundary condition: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: L-leucine
type: Species
is: CHEBI:15603
initial amount: NaN
is: HMDB00687

metaR AIRCr
name: phosphoribosylaminoimidazole carboxylase
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/6.3.2.6
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110024#
is described by: ECO:0000269
fast: false
type: Reaction
reversible: true
is: SBO:0000176

metaM hdd2crn c
is: HMDB06317
has only substance units: false
initial amount: NaN
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h17-18,21H,5-16,19-20H2,1-4H3/b18-17+
constant: false
name: trans-Hexadec-2-enoyl carnitine
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_b2fbad8e_51bc_493b_ade9_6385bd7d6ded
is encoded by: hsa:115286
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: SLC25A26
is: F8WAB8
initial amount: NaN
boundary condition: true
type: Species

metaM prist c
name: pristanic acid
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB00795
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:51340
is: SBO:0000247

metaM udpgal g
constant: false
boundary condition: false
is: CHEBI:58439
has only substance units: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
name: UDP-D-galactose(2-)
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB00302
initial concentration: 1.0

metaR MI1PS
is described by: ECO:0000269
kinetic law: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: (51477.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 5.5.1.4 Confidence Level: 4 AUTHORS: PMID:12941308 NOTES:NCD
is version of: http://identifiers.org/ec-code/5.5.1.4
reversible: false
modifier: MODEL1310110024#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110024#
name: myo-Inositol-1-phosphate synthase
product: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_9d27d305_7260_470e_abc0_a588d8a81b39
is encoded by: hsa:6916
name: TBXAS1
boundary condition: true
is: Q53F23
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252

metaM dodecanac c
has only substance units: false
type: Species
name: Dodecanedioic acid
is: HMDB00623
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C12H20O4 CHARGE: -2

metaM thm c
type: Species
initial concentration: 1.0
is: SBO:0000247
name: Thiamin
constant: false
has only substance units: false
initial amount: NaN
is: C00378
notes: FORMULA: C12H17N4OS CHARGE: 1
boundary condition: false
is: HMDB00235
is: CHEBI:0

http://identifiers.org/biomodels.db/MODEL1310110024#_3d10fb4b_67bc_4793_b743_b6c77604f637
has only substance units: false
is: B2RDU6
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:4598
initial concentration: NaN
boundary condition: true
name: MVK

metaR HSAT3ly
reversible: false
fast: false
reactant: MODEL1310110024#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
product: MODEL1310110024#
kinetic law: MODEL1310110024#
is described by: ECO:0000000
name: heparan-glucosaminide N-acetyltransferase, lysosomal
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_a4eb5038_f0e4_4b8f_afe0_93c5a734b044
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:2352
is: SBO:0000252
name: FOLR3
is: Q05C14
type: Species
initial concentration: NaN

metaR r0504
is version of: http://identifiers.org/ec-code/2.3.3.10
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110024#
is described by: ECO:0000000
product: MODEL1310110024#
modifier: MODEL1310110024#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
reactant: MODEL1310110024#

metaR GASNASE3ly
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.5.1.26 Confidence Level: 4 AUTHORS: PMID:1703489,PMID:2401370,PMID:8002961 NOTES:NCD
fast: false
type: Reaction
name: glycosylasparaginase, lysosomal
product: MODEL1310110024#
is described by: ECO:0000000
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.26
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#

metaR ORNDC
name: Ornithine Decarboxylase
reversible: false
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (4953.1) SUBSYSTEM: Urea cycle EC Number: 4.1.1.17 Confidence Level: 4 AUTHORS: PMID:2317811 NOTES:JLR- added proton to balance
product: MODEL1310110024#
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.1.17
modifier: MODEL1310110024#
is described by: ECO:0000269

metaR GLYLEUPEPT1tc
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Glycylleucine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaR UPP3S
is described by: ECO:0000000
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/4.2.1.75
modifier: MODEL1310110024#
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (7390.1) SUBSYSTEM: Heme synthesis EC Number: 4.2.1.75 Confidence Level: 0 AUTHORS: PMID:3174619 NOTES:
kinetic law: MODEL1310110024#
reversible: false
name: uroporphyrinogen-III synthase

metaR RETI1
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reactant: MODEL1310110024#
is: SBO:0000176
kinetic law: MODEL1310110024#
product: MODEL1310110024#
name: retinol isomerase (11-cis)
fast: false
is described by: ECO:0000000
reversible: true
type: Reaction

metaM adn c
is: C00212
initial amount: NaN
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
has only substance units: false
initial concentration: 1.0
type: Species
name: Adenosine
constant: false
is: HMDB00050
is: SBO:0000247
is: CHEBI:16335
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110024#_c1a3c8cb_7317_4bf0_883a_8fac05c7952b
is encoded by: hsa:51727
is: B2R6S5
constant: false
initial concentration: NaN
name: CMPK1
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN

metaR ADMDC
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.50
type: Reaction
notes: GENE_ASSOCIATION: (262.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.1.50 Confidence Level: 4 AUTHORS: PMID:2460457 NOTES:
is described by: ECO:0000269
modifier: MODEL1310110024#
is: SBO:0000176
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
name: adenosylmethionine decarboxylase

metaR CLOHtex2
fast: false
kinetic law: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
product: MODEL1310110024#
is: SBO:0000185
reversible: false
modifier: MODEL1310110024#
name: chloride transport via hydroxide countertransport (2:1)
is described by: ECO:0000304
reactant: MODEL1310110024#

metaM 5mta e
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C11H15N5O3S CHARGE: 0
type: Species
initial amount: NaN
constant: false
is: CHEBI:17509
name: 5-Methylthioadenosine
is: SBO:0000247
is: C00170
boundary condition: false
is: HMDB01173

metaM odecrn m
constant: false
is: HMDB01114
name: octadecenoyl carnitine
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: C00412
is: SBO:0000247
is: CHEBI:57394
type: Species
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/t23-/m0/s1
initial amount: NaN

metaR ARACHt
fast: false
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
name: fatty acid transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110024#_112f5dc1_9157_419d_8c31_ab28052beecf
boundary condition: true
has only substance units: false
name: CHST3
is: SBO:0000252
is encoded by: hsa:9469
initial concentration: NaN
type: Species
is: Q7LGC8
constant: false
initial amount: NaN

metaR FAOXC122C101m
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:2-->C10:1)m
type: Reaction

metaR EX idour LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-iduronate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_8355dc93_4fb4_4ed7_8fa1_4a451ebfc1fe
is: SBO:0000252
boundary condition: true
has only substance units: false
name: GPX2
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
is: P18283
is encoded by: hsa:2877

metaR r0236
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
modifier: MODEL1310110024#
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.5.1.6
is: SBO:0000176
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
fast: false
kinetic law: MODEL1310110024#
reversible: true
is described by: ECO:0000000
product: MODEL1310110024#
type: Reaction

metaM ksi pre14 g
is: SBO:0000247
has only substance units: false
is: CHEBI:28067
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C143H230N10O114S4X CHARGE: -5
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 14
constant: false
type: Species

metaR LAPCOAl
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (53.1) SUBSYSTEM: CoA catabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:11923312,PMID:11994049 NOTES:IT. human enzymes overexpressed on E.coli, Pig Liver
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.2
reversible: false
type: Reaction
product: MODEL1310110024#
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
is described by: ECO:0000304
name: lysosomal acid phosphorylase (CoA)

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

metaM udpgal e
is: HMDB00302
has only substance units: false
boundary condition: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
name: UDP-D-galactose(2-)
is: CHEBI:58439
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

metaM phyt2ohcoa x
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C41H70N7O18P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O18P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)32(50)40(54)70-20-19-43-30(49)17-18-44-38(53)35(52)41(6,7)22-63-69(60,61)66-68(58,59)62-21-29-34(65-67(55,56)57)33(51)39(64-29)48-24-47-31-36(42)45-23-46-37(31)48/h23-29,32-35,39,50-52H,8-22H2,1-7H3,(H,43,49)(H,44,53)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/p-4/t26?,27?,28?,29-,32?,33-,34-,35+,39-/m1/s1 EHMN_ABBREVIATION: C07343
is: CHEBI:57334
boundary condition: false
is: HMDB01295
name: 2-hydroxyphytanoyl-CoA(4-)
type: Species
initial amount: NaN
has only substance units: false
constant: false

metaR r0502
fast: false
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.113
modifier: MODEL1310110024#
reactant: MODEL1310110024#
type: Reaction
product: MODEL1310110024#
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
reversible: true
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110024#

metaR KHte
is described by: ECO:0000134
product: MODEL1310110024#
is: SBO:0000185
fast: false
type: Reaction
reversible: true
name: KHte
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110024#_ba3a9db1_9a9f_4d05_b5ef_ef9939e8fea9
boundary condition: true
is encoded by: hsa:93034
constant: false
initial amount: NaN
is: Q96P26
type: Species
initial concentration: NaN
has only substance units: false
name: NT5C1B
is: SBO:0000252

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_eb0af171_11b6_47a6_9519_016a865394b4
name: _AI694761_1_c
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:AI694761

metaM cmpacna c
is: HMDB01176
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
constant: false
has only substance units: false
name: CMP-N-acetyl-beta-neuraminate(2-)
is: SBO:0000247
is: CHEBI:57812

http://identifiers.org/biomodels.db/MODEL1310110024#_ce0da2b5_f9b8_45d5_bc00_f01ee5b2a6f3
is: P13995
boundary condition: true
name: MTHFD2
has only substance units: false
initial concentration: NaN
is encoded by: hsa:10797
constant: false
type: Species
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_201f0973_ad33_4c16_968a_5d2ec2e640a8
is encoded by: hsa:9651
is: SBO:0000252
type: Species
has only substance units: false
name: PLCH2
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: O75038

http://identifiers.org/biomodels.db/MODEL1310110024#_47beec6e_933c_428f_a0ac_1a1cc1748cc0
constant: false
has only substance units: false
name: NDUFB1
type: Species
is: O75438
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4707

metaM ppcoa x
boundary condition: false
is: C00100
is: CHEBI:57392
name: Propanoyl-CoA
is: HMDB01275
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_03502982_e2bb_4bdb_8024_1069100f88d9
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
name: HSD17B10
is: Q99714
constant: false
initial amount: NaN
is encoded by: hsa:3028

metaM ser L e
initial amount: NaN
is: SBO:0000247
is: CHEBI:17115
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: HMDB00187
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
name: L-serine
type: Species

metaR RE0830C
reversible: true
product: MODEL1310110024#
type: Reaction
reactant: MODEL1310110024#
name: RE0830
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
fast: false
is: SBO:0000176
kinetic law: MODEL1310110024#
is described by: ECO:0000000

metaM ttdca e
boundary condition: false
is: C06424
name: tetradecanoate (n-C14:0)
initial amount: NaN
is: CHEBI:30807
is: HMDB00806
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
notes: FORMULA: C14H27O2 CHARGE: -1 EHMN_ABBREVIATION: C06424

metaM dece3coa m
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
name: 3-decenoylcoa
is: http://identifiers.org/pubchem.compound/16019966
initial concentration: 1.0
constant: false
type: Species

metaR THRGLNexR
reversible: true
is described by: ECO:0000304
kinetic law: MODEL1310110024#
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110024#
product: MODEL1310110024#
fast: false
type: Reaction
name: L-threonine/glycine reversible exchange
modifier: MODEL1310110024#

metaM 2mop c
is: HMDB01172
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57700
type: Species
constant: false
name: 2-methyl-3-oxopropanoate
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
initial amount: NaN

metaR GLUDym
name: glutamate dehydrogenase (NADP), mitochondrial
reversible: true
kinetic law: MODEL1310110024#
product: MODEL1310110024#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110024#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.4.1.3
fast: false

metaR ADK1
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.3
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
is: SBO:0000176
product: MODEL1310110024#
fast: false
reactant: MODEL1310110024#
name: adenylate kinase

metaM ha deg1 l
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:16336
notes: FORMULA: C22H33N2O16 CHARGE: -1
boundary condition: false
type: Species
name: hyaluronan degradation product 1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_ac1dd706_9ca1_4e43_a04f_6ea4ce24aaf5
has only substance units: false
is encoded by: hsa:3635
name: INPP5D
boundary condition: true
is: SBO:0000252
constant: false
is: Q92835
type: Species
initial amount: NaN
initial concentration: NaN

metaM leu L c
name: L-leucine
is: CHEBI:15603
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
constant: false
has only substance units: false
is: HMDB00687
initial concentration: 1.0

metaM leuktrC4 e
boundary condition: false
name: leukotriene C4(2-)
is: CHEBI:57973
has only substance units: false
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB01198

metaR MI1PP
type: Reaction
fast: false
is described by: ECO:0000269
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
name: myo-inositol 1-phosphatase
product: MODEL1310110024#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.25
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
is: SBO:0000176
reactant: MODEL1310110024#

metaM udpgal c
name: UDP-D-galactose(2-)
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
type: Species
is: HMDB00302
initial concentration: 1.0
is: CHEBI:58439
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_a3a4705f_4ac7_43d6_a696_73e1a61ceaa6
boundary condition: true
constant: false
has only substance units: false
type: Species
is encoded by: hsa:57379
is: Q546Y9
name: AICDA
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaM prostgd2 r
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
name: prostaglandin D2(1-)
initial amount: NaN
is: CHEBI:57406
is: SBO:0000247
is: HMDB01403
constant: false

metaR METS
product: MODEL1310110024#
reactant: MODEL1310110024#
fast: false
name: methionine synthase
modifier: MODEL1310110024#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (4548.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.1.1.13 Confidence Level: 4 AUTHORS: PMID:8968736,PMID:9013615 NOTES:Human Y/N: Y
is version of: http://identifiers.org/ec-code/2.1.1.13
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110024#

metaR RE0577C
reactant: MODEL1310110024#
is: SBO:0000176
reversible: true
fast: false
type: Reaction
product: MODEL1310110024#
name: RE0577
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
is version of: http://identifiers.org/ec-code/3.1.2.2
is version of: http://identifiers.org/ec-code/2.3.1.65
kinetic law: MODEL1310110024#
is described by: ECO:0000000
modifier: MODEL1310110024#

metaR ADK3
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
fast: false
reversible: true
is: SBO:0000176
name: adentylate kinase (GTP)
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
product: MODEL1310110024#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.3
modifier: MODEL1310110024#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_73eba0f2_2484_491c_aeaf_c37d30624cca
name: SCD5
is: Q86SK9
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false
is encoded by: hsa:79966
is: SBO:0000252

metaM ocdcea r
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C18H33O2 CHARGE: -1
name: octadecenoate (n-C18:1)
has only substance units: false
is: C00712
type: Species
is: CHEBI:0
constant: false
is: HMDB00207
boundary condition: false
initial concentration: 1.0

metaM naglc2p U c
is: CHEBI:18278
name: N-Acetyl-D-glucosaminyldiphosphodolichol, human uterine homolog
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C1105H1810N10O120P20 CHARGE: -20 INCHI: InChI=1S/C33H59NO12P2/c1-23(2)12-8-13-24(3)14-9-15-25(4)16-10-17-26(5)18-11-19-27(6)20-21-43-47(39,40)46-48(41,42)45-33-30(34-28(7)36)32(38)31(37)29(22-35)44-33/h12,14,16,18,27,29-33,35,37-38H,8-11,13,15,17,19-22H2,1-7H3,(H,34,36)(H,39,40)(H,41,42)/b24-14+,25-16+,26-18-/t27?,29-,30-,31-,32-,33-/m1/s1
initial amount: NaN
constant: false
type: Species
is: SBO:0000247

metaR G14T11g
product: MODEL1310110024#
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110024#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
kinetic law: MODEL1310110024#
fast: false
modifier: MODEL1310110024#
is described by: ECO:0000000

metaM srtn e
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
is: HMDB00259
constant: false
is: CHEBI:350546
type: Species
initial amount: NaN
name: serotonin(1+)

metaM adn e
is: SBO:0000247
name: Adenosine
initial concentration: 1.0
type: Species
is: C00212
is: HMDB00050
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:16335
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212

metaR FATP8t
is described by: ECO:0000269
kinetic law: MODEL1310110024#
is: SBO:0000185
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/6.2.1.7
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
fast: false
reversible: true
name: fatty acid electroneutral transport
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ

http://identifiers.org/biomodels.db/MODEL1310110024#_af9237d9_c520_427c_bee2_33b70d0cdfed
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: DPM3
initial concentration: NaN
is: Q9P2X0
has only substance units: false
is encoded by: hsa:54344

http://identifiers.org/biomodels.db/MODEL1310110024#_9b35150d_cfdc_402e_917a_b7d8ee4fc848
initial concentration: NaN
is encoded by: hsa:2530
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
name: FUT8
is: B4DFS7
has only substance units: false
type: Species

metaM ttdca c
notes: FORMULA: C14H27O2 CHARGE: -1 INCHI: InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)/p-1 EHMN_ABBREVIATION: C06424
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
name: myristate
is: CHEBI:30807
is: HMDB00806

metaR ATP1ter
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110024#
name: ADP/ATP transporter, endoplasmic reticulum
product: MODEL1310110024#
kinetic law: MODEL1310110024#
reversible: true

metaR EX ksii core4 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 4-linked) exchange
type: Reaction

metaM 5mta c
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C11H15N5O3S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00165 EHMN_ABBREVIATION: C00170
is: SBO:0000247
constant: false
is: HMDB01173
type: Species
has only substance units: false
name: 5-Methylthioadenosine
is: CHEBI:17509
initial amount: NaN
is: C00170

http://identifiers.org/biomodels.db/MODEL1310110024#_51cfebed_4d2f_47c8_9d94_93ad063ebf24
name: ENTPD4
has only substance units: false
is encoded by: hsa:9583
initial concentration: NaN
constant: false
is: Q9Y227
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252

metaM leu L e
is: CHEBI:15603
has only substance units: false
name: L-leucine
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB00687
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
initial concentration: 1.0

metaR THRCYSNaEx
reversible: false
product: MODEL1310110024#
type: Reaction
kinetic law: MODEL1310110024#
is described by: ECO:0000269
is: SBO:0000185
name: L-cysteine/L-threonine Na-dependent exchange (Thr-L in)
fast: false
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110024#

metaR ARGtiDF
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (6541.1) or (6542.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
reactant: MODEL1310110024#
is: SBO:0000185
type: Reaction
reversible: false
name: L-arginine transport via diffusion (extracellular to cytosol)
kinetic law: MODEL1310110024#
fast: false
modifier: MODEL1310110024#
is described by: ECO:0000269

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

metaR P450SCC1m
name: cholesterol monooxygenase
reactant: MODEL1310110024#
reversible: true
product: MODEL1310110024#
fast: false
kinetic law: MODEL1310110024#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
type: Reaction
is: SBO:0000176

metaR RETI2
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110024#
is described by: ECO:0000000
reactant: MODEL1310110024#
type: Reaction
name: retinol isomerase (9-cis)
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
product: MODEL1310110024#

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_e27c1beb_390a_4290_ae2f_4acc4ebffd47
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:6576
is: D9HTE9
is: SBO:0000252
has only substance units: false
boundary condition: true
name: SLC25A1

metaR F6Tg
notes: GENE_ASSOCIATION: (2530.4) or (2530.1) or (2530.3) or (2530.2) or (2530.5) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.68 Confidence Level: 0 AUTHORS: PMID:14514715 NOTES:NCD
name: glycoprotein 6-alpha-L-fucosyltransferase
is version of: http://identifiers.org/ec-code/2.4.1.68
type: Reaction
is described by: ECO:0000000
reversible: false
product: MODEL1310110024#
is: SBO:0000176
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false
reactant: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_8ea8ae15_483a_4c8f_b9a9_d2b58411de15
has only substance units: false
name: _AI601100_1_m
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AI601100

metaM adrncoa m
is: http://identifiers.org/pubchem.compound/47205480
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
is: C16170
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
boundary condition: false
type: Species
name: adrenyl coenzyme A

metaR DINt
type: Reaction
name: deoxyinosine transport via diffusion
is: SBO:0000185
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
kinetic law: MODEL1310110024#
is described by: ECO:0000000
reactant: MODEL1310110024#
fast: false
reversible: true

metaM c226coa c
boundary condition: false
is: C16169
initial amount: NaN
initial concentration: 1.0
name: cervonyl coenzyme A
has only substance units: false
constant: false
type: Species
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
is: http://identifiers.org/pubchem.compound/47205479
is: SBO:0000247

metaR UDPDOLPT L
reactant: MODEL1310110024#
type: Reaction
kinetic law: MODEL1310110024#
product: MODEL1310110024#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.117
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:8280060 NOTES:NCD
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (liver)
modifier: MODEL1310110024#
is: SBO:0000176
is described by: ECO:0000000
reversible: false

metaR r0660
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
product: MODEL1310110024#
is: SBO:0000176
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.2
is described by: ECO:0000000
modifier: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_e1f7a0cc_df99_4838_8923_a4fdfb7ad38d
boundary condition: true
name: ST3GAL3
type: Species
is encoded by: hsa:6487
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN

metaM n2m2mn l
type: Species
is: CHEBI:17588
notes: FORMULA: C42H71N3O31 CHARGE: 0
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB00742
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: de-Fuc, reducing GlcNAc removed, de-Sia, de-Gal form of PA6 (w/o peptide linkage)

metaR PROSTGH2t
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
name: Prostaglandin H2 transport
fast: false
is: SBO:0000185
type: Reaction

metaR S6TASE26ly
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
fast: false
product: MODEL1310110024#
reversible: true
name: N-acetylglucosamine-6-sulfatase, lysosomal
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.14
type: Reaction

metaM fru e
is: HMDB00660
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
boundary condition: false
is: C00095
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:15824
name: D-Fructose

metaM 2oxoadp m
is: SBO:0000247
type: Species
is: CHEBI:57499
has only substance units: false
name: 2-oxoadipate(2-)
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
is: HMDB00225
initial amount: NaN

metaM 3sala m
is: C00606
notes: FORMULA: C3H5NO4S CHARGE: -2 INCHI: InChI=1S/C3H7NO4S/c4-2(3(5)6)1-9(7)8/h2H,1,4H2,(H,5,6)(H,7,8)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
name: 3-sulfino-L-alanine (1-)
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:61085
initial amount: NaN

metaM CE5101 m
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101
is: CHEBI:57795
is: SBO:0000247
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)

http://identifiers.org/biomodels.db/MODEL1310110024#_021632b9_3c77_4de6_93ca_8a2509f391c1
is: Q14442
boundary condition: true
initial amount: NaN
is encoded by: hsa:5283
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
type: Species
name: PIGH

metaR FAOXC184x
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:4)x
type: Reaction

metaR GLCAASE9ly
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is: SBO:0000176
product: MODEL1310110024#
reversible: false
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.2.1.31
name: beta-glucuronidase, lysosomal
modifier: MODEL1310110024#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110024#_23346509_830c_420b_8d8e_8e7e60dc201f
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AA854479
type: Species
name: _AA854479_1_m

metaM ahcys m
is: C00021
type: Species
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:16680
name: S-Adenosyl-L-homocysteine
is: SBO:0000247
is: HMDB00939
has only substance units: false
initial concentration: 1.0

metaM hdd2crn m
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h17-18,21H,5-16,19-20H2,1-4H3/b18-17+
boundary condition: false
name: trans-Hexadec-2-enoyl carnitine
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB06317

metaM dha e
has only substance units: false
is: SBO:0000247
is: CHEBI:16016
boundary condition: false
is: HMDB01882
constant: false
initial concentration: 1.0
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
type: Species
initial amount: NaN
name: glycerone

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

metaM cs e l
notes: FORMULA: C45H64N2O55S6 CHARGE: -8
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:36005
is: HMDB02183
constant: false
boundary condition: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), free chain
type: Species
is: SBO:0000247

metaR G12MT2 L
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
fast: false
is: SBO:0000176
name: Glycolipid 1,2-alpha-D-mannosyltransferase (liver)
product: MODEL1310110024#
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000000
reversible: false
type: Reaction

metaR EX pglyc hs LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylglycerol (homo sapiens) exchange
type: Reaction

metaR TRPt
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
name: L-tryptophan transport
product: MODEL1310110024#
reversible: true
fast: false
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:

metaR EX dcsptn1 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: docosa-4,7,10,13,16-pentaenoic acid (n-6) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_f0be8bcd_db2f_4e4f_8562_8534e6fde979
name: BLVRA
is: P53004
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:644
type: Species
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252

metaM acac x
is: CHEBI:13705
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB00060
boundary condition: false
initial amount: NaN
type: Species
name: acetoacetate

metaR EX 4hphac LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Hydroxyphenylacetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_14868226_c6bf_4f6d_8c49_3c1fd101f94a
name: TREH
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
is: O43280
is encoded by: hsa:11181
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_b09e4e71_e43a_4316_8fa5_7415c30404bd
name: FADS1
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:3992
initial concentration: NaN
type: Species
constant: false
has only substance units: false
boundary condition: true
is: O60427

metaR CMPACNAtn
reversible: false
reactant: MODEL1310110024#
product: MODEL1310110024#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110024#
fast: false
name: CMP-Sia nuclear export
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaR RE3565C
is: SBO:0000176
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
name: RE3565
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
fast: false
type: Reaction
product: MODEL1310110024#

metaM thbpt4acam n
is: HMDB02281
boundary condition: false
is: CHEBI:15374
type: Species
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
name: 4a-hydroxytetrahydrobiopterin
is: SBO:0000247
initial concentration: 1.0

metaM fru c
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
is: HMDB00660
boundary condition: false
is: C00095
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
name: D-Fructose
initial amount: NaN
is: CHEBI:15824
has only substance units: false

metaR r0661
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is: SBO:0000176
reactant: MODEL1310110024#
reversible: false
fast: false
type: Reaction
kinetic law: MODEL1310110024#
product: MODEL1310110024#
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17

metaR ABUTD
notes: GENE_ASSOCIATION: (223.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.19 Confidence Level: 4 AUTHORS: PMID:8786138 NOTES:JLR
fast: false
name: Aminobutyraldehyde dehydrogenase
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: false
type: Reaction
product: MODEL1310110024#
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_ac690793_d4d0_4ee0_8e9e_86cf13958d5f
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:29968
has only substance units: false
constant: false
boundary condition: true
name: PSAT1
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_220f2e69_911d_4f0d_97fd_f41e15a63e4f
is encoded by: hsa:1375
constant: false
is: E9PCP2
name: CPT1B
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false

metaM HC00250 c
constant: false
initial concentration: 1.0
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
boundary condition: false
name: hydrosulfide
has only substance units: false
type: Species
is: CHEBI:29919
initial amount: NaN
is: SBO:0000247

metaR NACHEX10ly
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
type: Reaction
reversible: false
is: SBO:0000176
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110024#
fast: false
name: beta-N-acetylhexosaminidase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110024#_d54be1da_1dc0_4810_aee0_96363694081b
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
name: SHMT1
type: Species
is encoded by: hsa:6470
is: SBO:0000252

metaM hs deg8 l
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: heparan sulfate, degradation product 8
type: Species
notes: FORMULA: C69H100N4O81S8 CHARGE: -10
is: CHEBI:16126
has only substance units: false
constant: false

metaR GK1
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110024#
fast: false
product: MODEL1310110024#
modifier: MODEL1310110024#
name: guanylate kinase (GMP:ATP)
is version of: http://identifiers.org/ec-code/2.7.4.8
type: Reaction
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
kinetic law: MODEL1310110024#

metaR CH25H
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
product: MODEL1310110024#
reversible: false
is: SBO:0000176
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (9023.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/1.14.99.38
is described by: ECO:0000269
modifier: MODEL1310110024#
name: cholesterol 25-hydroxylase

metaM pa hs n
initial concentration: 1.0
type: Species
boundary condition: false
name: phosphatidate(2-)
is: SBO:0000247
is: CHEBI:57739
initial amount: NaN
constant: false
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
has only substance units: false

metaR RE2079R
reactant: MODEL1310110024#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
fast: false
type: Reaction
name: RE2079
product: MODEL1310110024#
reversible: true
kinetic law: MODEL1310110024#

metaR ACGAMPM
product: MODEL1310110024#
reactant: MODEL1310110024#
modifier: MODEL1310110024#
is described by: ECO:0000269
kinetic law: MODEL1310110024#
name: phosphoacetylglucosamine mutase
is version of: http://identifiers.org/ec-code/5.4.2.3
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110024#_cb9b8e5b_5648_46ea_b1e2_39c054183371
type: Species
is encoded by: hsa:481
boundary condition: true
is: A3KLL5
constant: false
name: ATP1B1
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_459b65d7_636c_4f68_adaa_2ddd204d71ab
type: Species
has only substance units: false
constant: false
is encoded by: hsa:5277
is: SBO:0000252
name: PIGA
boundary condition: true
is: P37287
initial concentration: NaN
initial amount: NaN

metaM dhcrm hs c
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126
is: CHEBI:31488
name: dihydroceramide
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_c430e8df_e959_4f7c_be29_762c83b4439c
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
name: NOS1
constant: false
is: B4DG68
is encoded by: hsa:4842

metaR EX tdchola LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: taurochenodeoxycholate exchange
type: Reaction

metaM 3dpdhb me m
name: 3-Decaprenyl-4-hydroxy-5-methoxybenzoate
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C58H87O4 CHARGE: -1 INCHI: InChI=1S/C58H88O4/c1-44(2)22-13-23-45(3)24-14-25-46(4)26-15-27-47(5)28-16-29-48(6)30-17-31-49(7)32-18-33-50(8)34-19-35-51(9)36-20-37-52(10)38-21-39-53(11)40-41-54-42-55(58(60)61)43-56(62-12)57(54)59/h22,24,26,28,30,32,34,36,38,40,42-43,59H,13-21,23,25,27,29,31,33,35,37,39,41H2,1-12H3,(H,60,61)/b45-24+,46-26+,47-28+,48-30+,49-32+,50-34+,51-36+,52-38+,53-40+
is: CHEBI:50776
has only substance units: false
type: Species
boundary condition: false

metaR FAOXC226C227m
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:7)m
type: Reaction

metaR r0399
product: MODEL1310110024#
is described by: ECO:0000000
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.2.4.2
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
fast: false
reversible: true
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:
is: SBO:0000176
type: Reaction
reactant: MODEL1310110024#
modifier: MODEL1310110024#

metaR FAOXC2051843m
is described by: ECO:0000000
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reversible: false
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
reactant: MODEL1310110024#
product: MODEL1310110024#
modifier: MODEL1310110024#
name: Beta oxidation of fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3

metaR G13MT U
reactant: MODEL1310110024#
is: SBO:0000176
kinetic law: MODEL1310110024#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.132
product: MODEL1310110024#
name: Glycolipid 1,3-alpha-D-mannosyltransferase (uterus)
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (85365.1) or (85365.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.132 Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110024#
fast: false

metaM glyc3p x
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
has only substance units: false
initial concentration: 1.0
is: C00093
boundary condition: false
constant: false
is: HMDB00126
is: SBO:0000247
initial amount: NaN
type: Species
name: Glycerol 3-phosphate
is: CHEBI:57597

metaR SEBCOACROT
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_efcd4eef_f452_4160_aaaf_c64f9dc9f4ca
initial concentration: NaN
is encoded by: hsa:518
initial amount: NaN
has only substance units: false
constant: false
type: Species
boundary condition: true
is: SBO:0000252
name: ATP5G3

metaR LYStiDF
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
name: L-lysine transport via diffusion (extracellular to cytosol)
notes: GENE_ASSOCIATION: (6541.1) or (6542.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
reversible: false
is described by: ECO:0000269
type: Reaction
fast: false
product: MODEL1310110024#
is: SBO:0000185

metaR CSNATm
is described by: ECO:0000269
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.7
name: carnitine O-aceyltransferase, mitochondrial
type: Reaction
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:3759988 NOTES:TDV
reversible: true
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
reactant: MODEL1310110024#
product: MODEL1310110024#

metaR ETHAK
is version of: http://identifiers.org/ec-code/2.7.1.82
reactant: MODEL1310110024#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.32
kinetic law: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110024#
name: Ethanolamine kinase
fast: false
reversible: false
notes: GENE_ASSOCIATION: (1119.2) or (55500.1) or (1119.1) or (55224.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.82 Confidence Level: 4 AUTHORS: NOTES:NCD

metaR EX creat LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Creatine exchange
type: Reaction

metaM rbt c
type: Species
has only substance units: false
name: D-ribitol
initial amount: NaN
is: CHEBI:15963
constant: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
is: HMDB00508
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110024#_fbe36c0e_16fc_452e_a2ec_06195d87d2c5
type: Species
has only substance units: false
initial amount: NaN
is: P23434
is encoded by: hsa:2653
constant: false
is: SBO:0000252
boundary condition: true
name: GCSH
initial concentration: NaN

metaM CE5117 m
initial amount: NaN
is: CHEBI:57923
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117
type: Species
is: SBO:0000247
constant: false
boundary condition: false

metaR FAOXC102m
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:2)m
type: Reaction

metaR r0666
reactant: MODEL1310110024#
fast: false
name: 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) Purine metabolism EC:6.3.3.1
modifier: MODEL1310110024#
product: MODEL1310110024#
reversible: true
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.2.4.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Purine synthesis EC Number: 6.3.3.1 Confidence Level: 0 AUTHORS: PMID:4084560 NOTES:
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110024#_3e0eefce_5e9a_485f_9a73_50240f9a8de6
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
is: Q6IBB3
is encoded by: hsa:9551
name: ATP5J2
type: Species
initial concentration: NaN
initial amount: NaN

metaR EX thr L LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Threonine exchange
type: Reaction

metaR HAS2
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
kinetic law: MODEL1310110024#
name: hyaluronan synthase
reversible: false
product: MODEL1310110024#
type: Reaction
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.4.1.212
is described by: ECO:0000269
modifier: MODEL1310110024#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110024#_24ace955_20e4_44f3_a6b6_c819b4163413
is: P14415
name: ATP1B2
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:482
type: Species
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110024#_18454c37_8a27_4e82_8ef0_3eaef970a259
name: SLC13A1
is: SBO:0000252
has only substance units: false
is: Q9BZW2
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:6561

metaM f26bp c
is: SBO:0000247
is: CHEBI:58579
type: Species
has only substance units: false
name: beta-D-fructofuranose 2,6-bisphosphate(4-)
is: HMDB01047
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-2-6(18-20(13,14)15)5(9)4(8)3(17-6)1-16-19(10,11)12/h3-5,7-9H,1-2H2,(H2,10,11,12)(H2,13,14,15)/p-4/t3-,4-,5+,6+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00484 EHMN_ABBREVIATION: C00665
initial amount: NaN
constant: false

metaR CSNATp
is: SBO:0000176
kinetic law: MODEL1310110024#
fast: false
type: Reaction
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:7829107 NOTES:NCD
reversible: true
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.3.1.7
name: carnitine O-acetyltransferase, reverse direction, peroxisomal
reactant: MODEL1310110024#
product: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_8976d90a_8dc3_464c_8d46_88261a9fc607
name: _H77542_1_r
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:H77542
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_ac9fb1b3_479b_46df_bb83_c99057a14c15
name: SULT1A1
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:6817

metaM crvnc c
name: cervonic acid, C22:6 n-3
is: CHEBI:36005
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C22H31O2 CHARGE: -1
initial amount: NaN
constant: false
is: HMDB02183
boundary condition: false

metaM ksi deg41 l
is: HMDB00143
constant: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 41
is: SBO:0000247
is: CHEBI:12936
notes: FORMULA: C34H58N2O26 CHARGE: 0
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_faefb759_065a_4970_9d55_528237195e3d
constant: false
is: SBO:0000252
is encoded by: hsa:3990
boundary condition: true
is: A6H8L5
initial concentration: NaN
type: Species
name: LIPC
has only substance units: false
initial amount: NaN

metaR SMPD3g
reversible: false
kinetic law: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
reactant: MODEL1310110024#
is described by: ECO:0000304
name: sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
modifier: MODEL1310110024#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.12
notes: GENE_ASSOCIATION: (55512.1) or (55512.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ

metaM 2docopencoa m
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
name: 2,7,10,13,16-docosapentenoylcoa
type: Species
constant: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/24892790

http://identifiers.org/biomodels.db/MODEL1310110024#_c0310b34_fe75_4ca5_bdcd_4350453689e6
is encoded by: hsa:2954
is: SBO:0000252
name: GSTZ1
has only substance units: false
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true

metaR THMPPtm
product: MODEL1310110024#
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:12014993 NOTES:IT
is described by: ECO:0000000
reactant: MODEL1310110024#
reversible: false
name: Thiamine diphosphate transport in via anion antiport, mitochondria
kinetic law: MODEL1310110024#

metaR EX lac D LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-lactate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_57e1471c_8b3f_4a93_9629_fb40f5668dfd
name: ASRGL1
initial concentration: NaN
type: Species
is: Q7L266
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:80150
initial amount: NaN

metaM pa hs m
constant: false
initial concentration: 1.0
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
name: phosphatidate(2-)
initial amount: NaN
type: Species
is: CHEBI:57739
is: SBO:0000247
has only substance units: false
boundary condition: false

metaM pchol hs r
is: SBO:0000247
is: CHEBI:16110
has only substance units: false
constant: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
type: Species
initial concentration: 1.0
name: Phosphatidylcholine
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_aa9d5b12_a72d_4bc1_89fb_838a9100a908
boundary condition: true
is: B4DIA3
is: SBO:0000252
is encoded by: hsa:6535
name: SLC6A8
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
type: Species

metaR HAS1
is version of: http://identifiers.org/ec-code/2.4.1.212
reversible: false
modifier: MODEL1310110024#
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
is: SBO:0000185
name: hyaluronan synthase
is described by: ECO:0000269
fast: false
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
type: Reaction

metaM 2ddecdicoa m
is: C05279
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
type: Species
is: HMDB11123
constant: false
name: 2,6-dodecadienoylcoa
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_4dd2495f_056d_4b3b_a29b_e7c17f4ad41a
boundary condition: true
initial concentration: NaN
name: FASN
is encoded by: hsa:2194
type: Species
has only substance units: false
is: SBO:0000252
constant: false
is: P49327
initial amount: NaN

metaR RE1709C
fast: false
reactant: MODEL1310110024#
name: RE1709
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
product: MODEL1310110024#
is described by: ECO:0000000

metaM glyclt c
is: SBO:0000247
type: Species
constant: false
boundary condition: false
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
name: glycolate
has only substance units: false
is: HMDB00115
initial concentration: 1.0
is: CHEBI:29805
initial amount: NaN

metaM rbt e
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:15963
name: D-ribitol
has only substance units: false
is: HMDB00508
is: SBO:0000247
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
boundary condition: false
type: Species

metaM 56dura c
boundary condition: false
initial concentration: 1.0
name: 5,6-dihydrouracil
constant: false
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
initial amount: NaN
is: CHEBI:15901
is: HMDB00076

metaR r0395
reactant: MODEL1310110024#
fast: false
name: Hypoxanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
is described by: ECO:0000000
kinetic law: MODEL1310110024#
is: SBO:0000176
type: Reaction
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:11993848,PMID:1643670,PMID:3010873,PMID:8343533 NOTES:
reversible: true

metaM m4masn g
constant: false
has only substance units: false
notes: FORMULA: C46H77N2O35X CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
is: C05881
boundary condition: false
name: (alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_a4840292_8249_4de9_ad53_56fb602c23b6
is: P05091
constant: false
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:217
name: ALDH2

metaR CYSTGL
fast: false
type: Reaction
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/4.4.1.1
reactant: MODEL1310110024#
is described by: ECO:0000269
kinetic law: MODEL1310110024#
name: cystathionine g-lyase
reversible: false
notes: GENE_ASSOCIATION: (1491.1) or (1491.2) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 4.4.1.1 Confidence Level: 4 AUTHORS: PMID:10727430,PMID:15189131 NOTES:NCD
product: MODEL1310110024#
is: SBO:0000176

metaR GALASE3ly
name: beta-galactosidase, lysosomal
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110024#
reversible: false

metaM crvnc e
is: HMDB02183
initial amount: NaN
constant: false
name: cervonic acid, C22:6 n-3
notes: FORMULA: C22H31O2 CHARGE: -1
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:36005

http://identifiers.org/biomodels.db/MODEL1310110024#_03c7e5be_0d24_4039_90d4_b0970c871a5f
name: PLCB4
is encoded by: hsa:5332
is: Q15147
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN

metaR DURIt
is: SBO:0000185
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
name: deoxyuridine transport via diffusion
fast: false
reversible: true
product: MODEL1310110024#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
type: Reaction

metaR FAOXTC122TC101m
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C12:2-->C10:1)m
type: Reaction

metaR NACHEX3ly
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110024#
name: beta-N-acetylhexosaminidase, lysosomal
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

metaM acac m
type: Species
boundary condition: false
name: acetoacetate
initial amount: NaN
is: HMDB00060
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: CHEBI:13705
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110024#_704c907f_24cc_4c58_b817_db7f08dafd92
is: B4DX94
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: PGM3
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:5238

metaR FAOXC16080m
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation of long chain fatty acid
fast: false
is: SBO:0000176
modifier: MODEL1310110024#
reactant: MODEL1310110024#
type: Reaction
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.3.99.3

metaR r0668
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
fast: false
modifier: MODEL1310110024#
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
kinetic law: MODEL1310110024#
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.19
reactant: MODEL1310110024#
is described by: ECO:0000000
product: MODEL1310110024#
type: Reaction
is: SBO:0000176

metaR N3Tg
name: N-acetylgalactosamine 3-beta-galactosyltransferase, Golgi apparatus
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.4.1.122
fast: false
reversible: false
product: MODEL1310110024#
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (56913.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.122 Confidence Level: 0 AUTHORS: PMID:11677243 NOTES:NCD
type: Reaction
is: SBO:0000176
modifier: MODEL1310110024#
is described by: ECO:0000000

metaM pydam c
notes: FORMULA: C8H13N2O2 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00416 EHMN_ABBREVIATION: C00534
name: Pyridoxamine
is: CHEBI:57761
is: SBO:0000247
boundary condition: false
is: HMDB01431
constant: false
initial amount: NaN
is: C00534
has only substance units: false
type: Species
initial concentration: 1.0

metaM c226coa m
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
is: http://identifiers.org/pubchem.compound/47205479
has only substance units: false
boundary condition: false
name: cervonyl coenzyme A
is: C16169
initial concentration: 1.0
is: SBO:0000247

metaR r0394
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110024#
fast: false
reversible: true
is: SBO:0000176
type: Reaction
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
kinetic law: MODEL1310110024#

metaM dece3coa x
initial concentration: 1.0
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966
has only substance units: false
initial amount: NaN
type: Species
name: 3-decenoylcoa
constant: false
is: SBO:0000247

metaR RE2999M
is: SBO:0000176
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reactant: MODEL1310110024#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110024#
fast: false
is described by: ECO:0000000
name: RE2999
kinetic law: MODEL1310110024#
type: Reaction
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/5.3.3.8

http://identifiers.org/biomodels.db/MODEL1310110024#_5ae3b3d4_7c8c_4316_9229_68dd21eac1a5
is: P51648
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:224
has only substance units: false
name: ALDH3A2

metaR ADNCYC
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (112.1) or (55811.1) or (109.1) or (112.2) or (114.1) or (108.1) or (113.1) or (107.1) or (196883.1) or (115.1) or (111.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.1 Confidence Level: 4 AUTHORS: PMID:10481931,PMID:11299302,PMID:11423534,PMID:11840511,PMID:12503609,PMID:12609998,PMID:12623444,PMID:1427768,PMID:14996950,PMID:15547246,PMID:7860067,PMID:7959689,PMID:8076676 NOTES:JLR
reactant: MODEL1310110024#
type: Reaction
is: SBO:0000176
name: adenylate cyclase
fast: false
is version of: http://identifiers.org/ec-code/4.6.1.1
product: MODEL1310110024#
reversible: false
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#

metaR NACHEX14ly
reactant: MODEL1310110024#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110024#
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
fast: false
product: MODEL1310110024#

metaM etha c
constant: false
boundary condition: false
has only substance units: false
name: etha[c]
initial concentration: 1.0
is: HMDB00149
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C2H8NO CHARGE: 1 INCHI: InChI=1S/C2H7NO/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00180 EHMN_ABBREVIATION: C00189
is: CHEBI:57603

http://identifiers.org/biomodels.db/MODEL1310110024#_05f09708_8487_401d_8c13_4999231387b7
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
name: ND4
initial concentration: NaN
is: P03905
initial amount: NaN
type: Species
is encoded by: hsa:4538

metaR FAOXC123x
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)x
type: Reaction

metaR UDPDOLPT U
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110024#
fast: false
type: Reaction
reactant: MODEL1310110024#
reversible: false
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (uterus)
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:10359825,PMID:8280060 NOTES:NCD
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.4.1.117

metaR RE1526M
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
is: SBO:0000176
type: Reaction
reactant: MODEL1310110024#
modifier: MODEL1310110024#
is described by: ECO:0000000
name: RE1526
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110024#

metaR CYTK5n
modifier: MODEL1310110024#
reactant: MODEL1310110024#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110024#
type: Reaction
product: MODEL1310110024#
reversible: true
name: cytidylate kinase (CMP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
fast: false

metaM 3hmp m
is: HMDB00023
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:11805
name: 3-hydroxy-2-methylpropanoate
constant: false
type: Species
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
has only substance units: false
initial concentration: 1.0

metaR ADSL1
modifier: MODEL1310110024#
is: SBO:0000176
reversible: false
reactant: MODEL1310110024#
type: Reaction
name: adenylosuccinate lyase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.3.2.2
kinetic law: MODEL1310110024#
product: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:

metaR DOLDPP Ler
product: MODEL1310110024#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110024#
fast: false
type: Reaction
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.6.1.43
notes: GENE_ASSOCIATION: (57171.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.6.1.43 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:NCD
reversible: false
name: Dolichyl-diphosphate phosphohydrolase, human (liver)
reactant: MODEL1310110024#

metaM 10fthf m
has only substance units: false
name: 10-formyltetrahydrofolate(2-)
type: Species
is: CHEBI:57454
initial amount: NaN
constant: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: HMDB00972
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR r0393
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.74
reactant: MODEL1310110024#
reversible: false
fast: false
kinetic law: MODEL1310110024#
is described by: ECO:0000000
modifier: MODEL1310110024#
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
is: SBO:0000176
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110024#_86680173_adb1_4430_8a9f_68a9ea14ba29
type: Species
name: PCCA
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5095
is: C9JPQ8
initial amount: NaN

metaM adrncoa c
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205480
constant: false
name: adrenyl coenzyme A
is: C16170
initial amount: NaN
type: Species

metaR FK
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.7.1.52
notes: GENE_ASSOCIATION: (197258.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.52 Confidence Level: 0 AUTHORS: NOTES:kh 1/6/03 NCD
is: SBO:0000176
modifier: MODEL1310110024#
is described by: ECO:0000000
product: MODEL1310110024#
fast: false
reversible: false
name: Fucokinase
type: Reaction

metaM glyald c
constant: false
is: CHEBI:17378
is: HMDB01051
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
has only substance units: false
name: D-Glyceraldehyde
boundary condition: false
type: Species
initial concentration: 1.0
is: C00577

metaR CMPACNAtg
reversible: true
reactant: MODEL1310110024#
fast: false
type: Reaction
name: CMP-Sia Golgi transport via CMP antiport
is described by: ECO:0000269
kinetic law: MODEL1310110024#
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD
is: SBO:0000185
modifier: MODEL1310110024#

metaR CPPPGO
product: MODEL1310110024#
reversible: false
is described by: ECO:0000304
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: (1371.1) SUBSYSTEM: Heme synthesis EC Number: 1.3.3.3 Confidence Level: 2 AUTHORS: PMID:8407975 NOTES:r0608, JLR
modifier: MODEL1310110024#
name: coproporphyrinogen oxidase (O2 required)
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.3
is: SBO:0000176

metaR RPE
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/5.1.3.1
is described by: ECO:0000000
name: ribulose 5-phosphate 3-epimerase
product: MODEL1310110024#
reversible: true
fast: false
modifier: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_fb9e1abb_5286_4e32_b90d_445adc9fe83d
name: DLD
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
is: P09622
is encoded by: hsa:1738
initial concentration: NaN
constant: false

metaR ADSL2
kinetic law: MODEL1310110024#
type: Reaction
product: MODEL1310110024#
fast: false
name: adenylosuccinate lyase
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Purine synthesis EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
is version of: http://identifiers.org/ec-code/4.3.2.2
reversible: false
reactant: MODEL1310110024#
modifier: MODEL1310110024#
is: SBO:0000176
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110024#_104e7b60_8775_4d92_a2d1_5ebf1f8f6828
constant: false
is encoded by: hsa:1650
initial concentration: NaN
has part: Q53G02
has part: P04843
has part: P39656
has only substance units: false
is encoded by: hsa:6184
is encoded by: hsa:1603
boundary condition: true
initial amount: NaN
type: Species
name: DAD1:DDOST:RPN1:RPN2
has part: P04844
is encoded by: hsa:6185
is: SBO:0000297

metaR r0392
reversible: true
fast: false
kinetic law: MODEL1310110024#
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
type: Reaction
reactant: MODEL1310110024#

metaR G12MT2 U
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110024#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
name: Glycolipid 1,2-alpha-D-mannosyltransferase (uterus)
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
type: Reaction
fast: false

metaM pa hs r
has only substance units: false
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
is: CHEBI:57739
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
name: phosphatidate(2-)
is: SBO:0000247
initial amount: NaN

metaR AHEXASEly
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
reactant: MODEL1310110024#
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
fast: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110024#
is described by: ECO:0000000
product: MODEL1310110024#
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.2.1.52

metaM gdpfuc g
name: GDP-L-fucose(2-)
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB01095
type: Species
has only substance units: false
is: CHEBI:57984
boundary condition: false
constant: false
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325

http://identifiers.org/biomodels.db/MODEL1310110024#_27e83d8f_5dca_42df_b332_f4a20c637191
is encoded by: hsa:6534
is: Q99884
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
name: SLC6A7
has only substance units: false
is: SBO:0000252
constant: false

metaR HIBDm
type: Reaction
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
is: SBO:0000176
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.31
is described by: ECO:0000269
modifier: MODEL1310110024#
product: MODEL1310110024#

metaR LNLNCGCRNt
reversible: false
reactant: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110024#
name: transport into the mitochondria (carnitine)
modifier: MODEL1310110024#
is: SBO:0000185
is described by: ECO:0000269
fast: false
product: MODEL1310110024#

metaM ha pre1 l
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: hyaluronan biosynthesis, precursor 1
constant: false
is: CHEBI:16126
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
is: SBO:0000247

metaR r0669
reversible: false
type: Reaction
is: SBO:0000176
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
fast: false
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000000
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:

metaR D LACt2
is: SBO:0000185
name: D-lactate transport via proton symport
reversible: true
product: MODEL1310110024#
modifier: MODEL1310110024#
reactant: MODEL1310110024#
type: Reaction
kinetic law: MODEL1310110024#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR

metaR ALADGLYexR
reactant: MODEL1310110024#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110024#
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110024#
fast: false
name: D-alanine/glycine reversible exchange
product: MODEL1310110024#

metaR PIPLC
product: MODEL1310110024#
name: phosphatidylinositol phospholipase C
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.11
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (23007.1) or (113026.1) or (89869.1) or (84812.1) or (9651.1) or (5335.1) or (51196.1) or (257068.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (5330.1) or (23236.1) or (5333.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
modifier: MODEL1310110024#
type: Reaction
reactant: MODEL1310110024#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110024#

metaM 2docopencoa x
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
name: 2,7,10,13,16-docosapentenoylcoa
is: http://identifiers.org/pubchem.compound/24892790
is: SBO:0000247
has only substance units: false
type: Species
constant: false

metaR r0391
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 2.4.2.11 Confidence Level: 0 AUTHORS: PMID:17604275 NOTES:
kinetic law: MODEL1310110024#
reversible: true
product: MODEL1310110024#
name: Nicotinate D-ribonucleotide:pyrophosphate phosphoribosyltransferase Nicotinate and nicotinamide metabolism EC:2.4.2.11
is described by: ECO:0000000
reactant: MODEL1310110024#
fast: false
is: SBO:0000176
type: Reaction

metaR C4STMO2r
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (6307.1) or (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
is version of: http://identifiers.org/ec-code/1.1.1.170
is described by: ECO:0000000
name: C-4 methyl sterol oxidase
type: Reaction
modifier: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
reversible: false
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.14.13.72

http://identifiers.org/biomodels.db/MODEL1310110024#_d7cbf97f_bdd0_4af9_a77b_bc8042d462c4
name: _AI684467_1_m
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:AI684467

metaR ADRNCRNt
kinetic law: MODEL1310110024#
product: MODEL1310110024#
is: SBO:0000185
modifier: MODEL1310110024#
name: transport into the mitochondria (carnitine)
notes: GENE_ASSOCIATION: (788.1) or (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
reversible: false
type: Reaction
fast: false
reactant: MODEL1310110024#

metaR PSFLIPm
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
product: MODEL1310110024#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.6.3.1
reversible: false
type: Reaction
name: phosphatidylserine flippase
is described by: ECO:0000269
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ
fast: false

http://identifiers.org/biomodels.db/MODEL1310110024#_cb996f1c_6737_4fa6_bc71_45ceae8a4e9d
is: SBO:0000297
has part: P37287
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
is encoded by: hsa:8818
boundary condition: true
constant: false
is encoded by: hsa:5277

http://identifiers.org/biomodels.db/MODEL1310110024#_5925ae9b_717d_460a_b8ce_c6766c5ab41a
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
is: Q8WUX1
initial concentration: NaN
constant: false
name: SLC38A5
is encoded by: hsa:92745
initial amount: NaN

metaM pchol hs m
type: Species
is: SBO:0000247
name: Phosphatidylcholine
has only substance units: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
initial concentration: 1.0
boundary condition: false
is: CHEBI:16110
initial amount: NaN
constant: false

metaR r0390
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
kinetic law: MODEL1310110024#
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
is described by: ECO:0000000
product: MODEL1310110024#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110024#
reversible: true

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_4198a423_94fb_412b_8bdb_fb4a01ca6fd4
is: SBO:0000252
is: P51648
initial concentration: NaN
name: ALDH3A2
has only substance units: false
is encoded by: hsa:224
boundary condition: true
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_6f313982_8436_4e7e_acaa_c15f1b6f3e58
name: MYO5B
is: SBO:0000252
initial amount: NaN
type: Species
is: Q9H6Y6
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:4645

http://identifiers.org/biomodels.db/MODEL1310110024#_a431ffe5_0a65_4219_854d_18b5fcddb564
initial concentration: NaN
is: SBO:0000252
type: Species
name: ST3GAL3
has only substance units: false
constant: false
is encoded by: hsa:6487
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110024#_2aa9e995_022a_46aa_ad40_ae699a89be39
boundary condition: true
is encoded by: hsa:6818
initial amount: NaN
initial concentration: NaN
name: SULT1A3
is: P50224
has only substance units: false
is: SBO:0000252
constant: false
type: Species

metaM pcrn x
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
is: http://identifiers.org/pubchem.compound/107738
name: propionyl-carnitine
is: HMDB00824
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_56df78eb_4d6b_4f14_8891_4a02bfc3bea7
is encoded by: hsa:4524
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: Q59GJ6
boundary condition: true
name: MTHFR
initial concentration: NaN
constant: false
type: Species

metaR RE1709N
modifier: MODEL1310110024#
is: SBO:0000176
name: RE1709
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.96
product: MODEL1310110024#
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#

metaM m5mpdol U r
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C1545H2540N20O470P20 CHARGE: -20
is: CHEBI:37634
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial amount: NaN

metaM 2ddecdicoa x
is: HMDB11123
type: Species
is: C05279
has only substance units: false
name: 2,6-dodecadienoylcoa
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4

metaR FAOXC102x
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:2)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_0122a4a9_80de_4009_bd54_bb5a4d5ef826
has only substance units: false
initial concentration: NaN
is encoded by: hsa:522
name: ATP5J
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false

metaR HOCTDACBP
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyoctadecenoylcoa from mitochondria into the cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_a5d010e7_4391_43ea_8399_690623ba39a0
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is: Q14916
type: Species
is encoded by: hsa:6568
name: SLC17A1

metaM decdp c
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB06288
notes: FORMULA: C50H81O7P2 CHARGE: -3 INCHI: InChI=1/C50H90O7P2/c1-41(2)21-31-53-58(51,54-32-22-42(3)4)57-59(52,35-25-45(9)10,36-26-46(11)12,37-27-47(13)14,38-28-48(15)16,39-29-49(17)18,40-30-50(19)20,55-33-23-43(5)6)56-34-24-44(7)8/h21-30H,31-40H2,1-20H3
initial amount: NaN
constant: false
has only substance units: false
name: all trans Decaprenyl diphosphate
initial concentration: 1.0

metaR RPI
fast: false
is: SBO:0000176
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110024#
name: ribose-5-phosphate isomerase
is version of: http://identifiers.org/ec-code/5.3.1.6
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
kinetic law: MODEL1310110024#
product: MODEL1310110024#
modifier: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_f34082b4_3497_47fb_acff_b77fd5672566
type: Species
initial concentration: NaN
is encoded by: hsa:4726
constant: false
is: Q6IBC4
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: NDUFS6

http://identifiers.org/biomodels.db/MODEL1310110024#_ccd45f6b_f700_4300_a596_a543ce0d0bb4
name: B3GNT1
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:11041
has only substance units: false
constant: false
boundary condition: true
type: Species
is: O43505

metaR G14T8g
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110024#
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
product: MODEL1310110024#
is: SBO:0000176
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110024#_36b65d63_63c7_4527_9776_3c2c4213581e
constant: false
boundary condition: true
is: Q5SPY7
has only substance units: false
type: Species
is encoded by: hsa:954
is: SBO:0000252
name: ENTPD2
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_0ec9da1c_f080_4104_b3ca_322df52a699f
name: PIK3C3
is encoded by: hsa:5289
boundary condition: true
type: Species
initial amount: NaN
is: Q8NEB9
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110024#_9f4250e9_7005_4416_89a1_74355e755fc5
is: E9PNG0
name: AMPD2
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:271
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN

metaM hdcea r
is: HMDB03229
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:32372
name: palmitoleate
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C16H29O2 CHARGE: -1 INCHI: InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7- HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
type: Species

metaM C05957 r
is: CHEBI:27485
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
name: Prostaglandin J2
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
constant: false
is: HMDB02710
boundary condition: false

metaM gdpfuc c
is: HMDB01095
name: GDP-L-fucose(2-)
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57984
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
has only substance units: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110024#_806597be_e60d_4a1d_9ac5_825be631049f
boundary condition: true
name: ALG3
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:10195

http://identifiers.org/biomodels.db/MODEL1310110024#_0113ebad_c467_47e8_b4bb_5d19e8ffe89b
is encoded by: hsa:AI620219
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
name: _AI620219_1_c

metaR r1743
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: false
is: SBO:0000185
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
is described by: ECO:0000000
modifier: MODEL1310110024#
name: Y+LAT2 Utilized transport
fast: false
product: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_ac7bdd4e_6d57_4e81_9711_220f5af96aa8
is encoded by: hsa:1491
has only substance units: false
is: SBO:0000252
type: Species
name: CTH
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: P32929

metaR GLUDxm
reactant: MODEL1310110024#
is: SBO:0000176
reversible: true
type: Reaction
is described by: ECO:0000269
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
is version of: http://identifiers.org/ec-code/1.4.1.3
modifier: MODEL1310110024#
name: glutamate dehydrogenase (NAD) (mitochondrial)
kinetic law: MODEL1310110024#
fast: false

metaR GALASE14ly
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
name: beta-galactosidase, lysosomal
kinetic law: MODEL1310110024#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
reactant: MODEL1310110024#

metaR PSDm hs
is version of: http://identifiers.org/ec-code/4.1.1.65
modifier: MODEL1310110024#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ
reversible: false
name: Phosphatidylserine decarboxylase
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_f96418c2_f752_41af_93d2_d53f23a170ef
initial amount: NaN
is: SBO:0000252
is: O00624
type: Species
constant: false
initial concentration: NaN
name: SLC17A2
boundary condition: true
has only substance units: false
is encoded by: hsa:10246

metaM xol27oh r
is: CHEBI:17703
is: HMDB02103
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: 26-hydroxycholesterol

metaR CERT2rt
name: ceramide transport protein
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
product: MODEL1310110024#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.7.11.1
modifier: MODEL1310110024#
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false
type: Reaction
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110024#_c493e15f_2c65_4290_9472_489bbeeea8ea
initial concentration: NaN
boundary condition: true
is: O75715
type: Species
name: GPX5
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:2880

metaM docohexcoa x
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
boundary condition: false
type: Species
constant: false
is: http://identifiers.org/pubchem.compound/24892790
has only substance units: false
is: SBO:0000247
name: 2,4,7,10,13,16-docosahexenoylcoa

http://identifiers.org/biomodels.db/MODEL1310110024#_e0e17dbe_65ac_4ca8_ba9c_ecc5cc8efcce
has only substance units: false
type: Species
constant: false
initial amount: NaN
name: PPCDC
is: Q96CD2
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:60490

http://identifiers.org/biomodels.db/MODEL1310110024#_adab85cc_98eb_435c_b7cb_bd9d4cf2f27f
has only substance units: false
has part: P42336
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5290
is: SBO:0000297
boundary condition: true
type: Species
has part: O00459
constant: false
name: PIK3CA:PIK3R2
is encoded by: hsa:5296

metaM sphgn c
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
initial concentration: 1.0
boundary condition: false
is: CHEBI:57817
name: sphinganine(1+)
is: HMDB00269
type: Species

metaR 3AIBTm
is version of: http://identifiers.org/ec-code/2.6.1.19
modifier: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.19.4 Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
is: SBO:0000176
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
name: L-3-aminoisobutyrate transaminase, mitochondrial
reversible: true
is described by: ECO:0000304

metaM ksi pre25 g
notes: FORMULA: C199H319N14O163S7X CHARGE: -8
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 25
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:58053
type: Species
has only substance units: false
is: C00130
is: HMDB00175
constant: false

metaR r1742
reactant: MODEL1310110024#
modifier: MODEL1310110024#
product: MODEL1310110024#
kinetic law: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000185
name: Y+LAT2 Utilized transport
reversible: false

metaR r1497
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076396,PMID:11819755,PMID:17404808,PMID:6384004 NOTES:
product: MODEL1310110024#
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110024#
is: SBO:0000185
reversible: false
name: Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter TCDB:2.A.28.1.1

http://identifiers.org/biomodels.db/MODEL1310110024#_85bd40d6_5a07_4290_aec4_e36129fad88e
name: ADA
is: SBO:0000252
is encoded by: hsa:100
type: Species
initial amount: NaN
is: P00813
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false

metaM pppg9 m
type: Species
is: HMDB01097
is: C01079
is: CHEBI:57307
initial amount: NaN
name: Protoporphyrinogen IX
initial concentration: 1.0
notes: FORMULA: C34H38N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00656 EHMN_ABBREVIATION: C01079
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false

metaR RE3520E
fast: false
is described by: ECO:0000000
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
name: RE3520
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
type: Reaction
product: MODEL1310110024#
modifier: MODEL1310110024#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.11.1.9

metaM phytcoa x
initial amount: NaN
is: CHEBI:57391
is: SBO:0000247
has only substance units: false
name: phytanoyl-CoA(4-)
is: HMDB01359
initial concentration: 1.0
constant: false
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
boundary condition: false
type: Species

metaR FAOXC101x
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_25d55e9e_db85_4eb8_acf3_e3d1cc74ddbd
initial concentration: NaN
is encoded by: hsa:5409
type: Species
boundary condition: true
name: PNMT
is: P11086
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_7c71549b_5791_41a5_ac28_acbad6d10418
type: Species
name: GLS2
boundary condition: true
initial amount: NaN
is encoded by: hsa:27165
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false

metaM cdpdag hs c
name: CDP-diacylglycerol(2-)
is: CHEBI:58332
has only substance units: false
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110024#_fcbc7d96_f6de_43d0_b29b_bc1623a50968
boundary condition: true
type: Species
name: _NM_001929_1_c
constant: false
initial concentration: NaN
is encoded by: hsa:NM 001929
is: SBO:0000252
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_3537255c_954d_413e_8a25_a9d53b20fad5
is encoded by: hsa:54677
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
name: CROT
has only substance units: false
is: E7EQF2
initial amount: NaN
constant: false

metaM ditp n
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
is: SBO:0000247
is: HMDB03537
initial concentration: 1.0
type: Species
name: dITP(4-)
boundary condition: false
is: CHEBI:61382

http://identifiers.org/biomodels.db/MODEL1310110024#_7eeea4dd_f4fc_426f_a15a_7bc117dc6e23
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
name: SLC12A7
is encoded by: hsa:10723
is: Q9Y666
boundary condition: true

metaR NRPPHRt4 2 r
fast: false
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reactant: MODEL1310110024#
name: Norepinephrine reversible transport in via sodium symport (1:2)
product: MODEL1310110024#

metaR EX ahdt LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 7,8-dihydroneopterin 3-triphosphate(4-)
type: Reaction

metaR FAOXC6DCC4DCx
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6DC-->C4DC)x
type: Reaction

metaR RE2626M
modifier: MODEL1310110024#
name: RE2626
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reversible: true
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.14.13.15

metaR TSULt4 3
reactant: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
name: thiosulfate transport via sodium symport
is: SBO:0000185
kinetic law: MODEL1310110024#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (6561.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10811962,PMID:11161786 NOTES:NCD
is described by: ECO:0000269
modifier: MODEL1310110024#

metaR BACCLm
modifier: MODEL1310110024#
is: SBO:0000176
reversible: false
fast: false
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 2 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
is described by: ECO:0000254
product: MODEL1310110024#
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/6.3.4.10
type: Reaction
kinetic law: MODEL1310110024#
name: biotin-[acetyl-CoA-carboxylase] ligase, mitochondrial

metaM CE5788 e
constant: false
is: HMDB02710
name: kinetensin 1-7
boundary condition: false
is: SBO:0000247
is: CHEBI:27485
has only substance units: false
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
initial amount: NaN
type: Species
initial concentration: 1.0

metaM mpdol U c
is: CHEBI:18396
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
type: Species
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human uterine homolog
notes: FORMULA: C1245H2040N20O220P20 CHARGE: -20

http://identifiers.org/biomodels.db/MODEL1310110024#_3f05bb61_d979_454e_ae28_9f2b19af5025
boundary condition: true
is encoded by: hsa:10400
name: PEMT
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
type: Species
initial amount: NaN

metaM ha pre1 e
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:16126
name: hyaluronan biosynthesis, precursor 1
type: Species
is: SBO:0000247

metaM HC02214 e
has only substance units: false
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
type: Species
boundary condition: false
name: prostaglandin-f1alpha
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28852
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_58ba524d_141c_43e2_a2c6_952d3ddc180f
is encoded by: hsa:6582
name: SLC22A2
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species

metaM ksi deg29 l
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C96H157N6O80S3 CHARGE: -3
constant: false
is: HMDB00143
boundary condition: false
name: keratan sulfate I, degradation product 29
is: CHEBI:12936
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110024#_be100b4c_7f0b_4c05_982b_1f748de8025a
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
name: FOLR1
initial concentration: NaN
is encoded by: hsa:2348
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_6025f0dc_77d7_417f_86f7_2b8ccc743982
is: SBO:0000252
initial amount: NaN
name: GALC
constant: false
is: P54803
is encoded by: hsa:2581
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR D3AIBTm
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
product: MODEL1310110024#
type: Reaction
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
reversible: true
reactant: MODEL1310110024#
fast: false
kinetic law: MODEL1310110024#
is: SBO:0000176
is described by: ECO:0000000

metaR SPHK21c
is version of: http://identifiers.org/ec-code/2.7.1.91
type: Reaction
reversible: false
is described by: ECO:0000269
is: SBO:0000176
fast: false
product: MODEL1310110024#
modifier: MODEL1310110024#
name: sphingosine kinase 2
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NJ

metaR GLYt4
type: Reaction
name: glycine transport via sodium symport
modifier: MODEL1310110024#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:SAB irreversible
kinetic law: MODEL1310110024#
fast: false
is: SBO:0000185
reactant: MODEL1310110024#
reversible: false
product: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_94860249_c9a0_40a1_bac0_1035fc1004e0
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:AA502753
has only substance units: false
constant: false
is: SBO:0000252
name: _AA502753_1_m

http://identifiers.org/biomodels.db/MODEL1310110024#_f67c2462_03b9_4715_80ee_1aed31b0004f
type: Species
name: ACADL
has only substance units: false
initial amount: NaN
is encoded by: hsa:33
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
is: P28330

http://identifiers.org/biomodels.db/MODEL1310110024#_be8ef4f4_e076_401c_8491_30161d54f380
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
name: HADH
has only substance units: false
is: SBO:0000252
is: Q16836
is encoded by: hsa:3033
constant: false

metaM pchol hs e
is: SBO:0000247
is: CHEBI:16110
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
constant: false
name: Phosphatidylcholine
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR HGNTOR
notes: GENE_ASSOCIATION: (3081.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.5 Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
product: MODEL1310110024#
name: Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
is described by: ECO:0000269
fast: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.13.11.5
reversible: false
modifier: MODEL1310110024#

metaM xol27oh m
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
is: CHEBI:17703
is: HMDB02103
name: 26-hydroxycholesterol
boundary condition: false

metaM ksi deg5 l
is: HMDB00143
type: Species
name: keratan sulfate I, degradation product 5
is: CHEBI:12936
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C222H356N15O194S11 CHARGE: -11
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110024#_5694f468_468f_4180_bc9d_b5c31d193da6
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:4715
is: SBO:0000252
name: NDUFB9
is: Q9Y6M9
constant: false

metaR ACNAMtn
product: MODEL1310110024#
is described by: ECO:0000000
kinetic law: MODEL1310110024#
type: Reaction
reactant: MODEL1310110024#
is: SBO:0000185
name: N-acetylneuraminate nuclear import
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: false
fast: false

metaM hs l
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
name: heparan sulfate, free chain
is: CHEBI:28815
constant: false
notes: FORMULA: C79H114N5O102S12 CHARGE: -13
initial amount: NaN
is: SBO:0000247

metaR ACGAMtly
name: N-acetyl-glucosamine lysosomal efflux
kinetic law: MODEL1310110024#
type: Reaction
reactant: MODEL1310110024#
is: SBO:0000185
fast: false
reversible: false
is described by: ECO:0000000
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD

metaM glyald m
is: CHEBI:17378
name: D-glyceraldehyde
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
is: HMDB01051
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaM dgsn c
constant: false
initial concentration: 1.0
name: Deoxyguanosine
is: HMDB00085
has only substance units: false
boundary condition: false
initial amount: NaN
is: C00330
type: Species
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
is: CHEBI:17172
is: SBO:0000247

metaR CYTK4n
reactant: MODEL1310110024#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
fast: false
name: cytidylate kinase (dCMP,GTP),nuclear
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
product: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_06e6b8f5_70ab_4549_860f_6ede6f3a2137
name: PPA2
initial concentration: NaN
boundary condition: true
is: F8WDN9
is encoded by: hsa:27068
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_e665a36d_e191_4bbe_842c_cf1e1675aff9
is encoded by: hsa:AI769281
boundary condition: true
name: _AI769281_1_e
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN

metaR DM atp c
is described by: ECO:0000134
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
reversible: false
type: Reaction
product: MODEL1310110024#
kinetic law: MODEL1310110024#
name: DM_atp(c)
fast: false
is: SBO:0000176

metaR FDH
kinetic law: MODEL1310110024#
is described by: ECO:0000304
modifier: MODEL1310110024#
fast: false
name: formate dehydrogenase
type: Reaction
is: SBO:0000176
reversible: false
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.5.1.6
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (10840.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.2.1.2 Confidence Level: 2 AUTHORS: NOTES:

metaR ARACHDt2
kinetic law: MODEL1310110024#
name: fatty acid transport via diffusion
product: MODEL1310110024#
reactant: MODEL1310110024#
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
type: Reaction

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_7ed3f356_1035_4220_b2a8_1745c96b9b39
boundary condition: true
has only substance units: false
is encoded by: hsa:55650
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
name: PIGV
is: Q9NUD9

metaM m2mpdol U c
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
constant: false
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:28049
initial concentration: 1.0
notes: FORMULA: C1365H2240N20O320P20 CHARGE: -20
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_b4d5f033_d124_4830_90d1_244dc889cc3f
initial amount: NaN
name: HAO2
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
type: Species
is encoded by: hsa:51179
has only substance units: false

metaR FUMm
type: Reaction
reversible: true
product: MODEL1310110024#
reactant: MODEL1310110024#
name: fumarase, mitochondrial
is: SBO:0000176
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.2
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: PMID:16774737,PMID:17111171,PMID:17111172 NOTES:IF. Biochemical

http://identifiers.org/biomodels.db/MODEL1310110024#_70d0b8f3_ca53_4739_a9fd_9c41b821fdbb
name: SLC43A2
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:124935
is: Q8N370
constant: false

metaR ADPACTD
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport into cytosol (diffusion)
type: Reaction

metaR LPS2e
fast: false
is described by: ECO:0000000
reactant: MODEL1310110024#
modifier: MODEL1310110024#
type: Reaction
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.3 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:carbonyl and extra H accounted for in R group NJ
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.1.1.3
is: SBO:0000176
reversible: false
name: lipase, extracellular

http://identifiers.org/biomodels.db/MODEL1310110024#_e296e428_7255_4e85_8ed0_0a9296717a64
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
name: PRDX1
initial concentration: NaN
is encoded by: hsa:5052
constant: false

metaM pcrn m
initial amount: NaN
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
type: Species
is: http://identifiers.org/pubchem.compound/107738
initial concentration: 1.0
name: propionyl-carnitine
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB00824
constant: false

metaM cs a deg3 l
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB00127
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 3
is: CHEBI:15748
notes: FORMULA: C31H48NO32S2 CHARGE: -3
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_690e423b_453f_4f81_85cf_46832c6fb047
name: B3GALT5
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10317
constant: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110024#_1720aad7_b82e_4231_b86f_b3eddb213dae
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

metaM ksi deg9 l
is: CHEBI:12936
type: Species
notes: FORMULA: C188H301N13O166S10 CHARGE: -10
initial amount: NaN
has only substance units: false
is: HMDB00143
is: SBO:0000247
initial concentration: 1.0
name: keratan sulfate I, degradation product 9
constant: false
boundary condition: false

metaR FRDPtc
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
fast: false
is: SBO:0000185
name: lipid, flip-flop intracellular transport
type: Reaction
product: MODEL1310110024#
kinetic law: MODEL1310110024#
is described by: ECO:0000000
reversible: true

metaR FADH2tru
kinetic law: MODEL1310110024#
is: SBO:0000185
product: MODEL1310110024#
fast: false
type: Reaction
name: FADH2 transporter, endoplasmic reticulum
is described by: ECO:0000000
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
reversible: false

metaM ksi pre36 g
notes: FORMULA: C247H394N17O210S11X CHARGE: -12
is: CHEBI:28067
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 36
constant: false
initial amount: NaN
type: Species
boundary condition: false

metaR LNSTLSr
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/5.4.99.7
notes: GENE_ASSOCIATION: (4047.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.4.99.7 Confidence Level: 2 AUTHORS: PMID:17925399,PMID:17925400,PMID:18830876,PMID:18830877 NOTES:NCD ER version - NJ
product: MODEL1310110024#
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
fast: false
reversible: false
type: Reaction
modifier: MODEL1310110024#
is: SBO:0000176
name: lanosterol synthase

http://identifiers.org/biomodels.db/MODEL1310110024#_e1e6264a_7675_48ab_98b2_5b342654b0ae
initial amount: NaN
name: SC5DL
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
is: Q6GTM5
has only substance units: false
is encoded by: hsa:6309
boundary condition: true

metaM pchol hs c
type: Species
boundary condition: false
name: Phosphatidylcholine
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
is: SBO:0000247
is: CHEBI:16110
constant: false

metaM glyb c
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:17750
initial amount: NaN
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
is: HMDB00043
type: Species
name: glycine betaine

metaR TSTSTERONEt
name: Testosterone transport
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.8.2.2 Confidence Level: 2 AUTHORS: PMID:1588921,PMID:16399349 NOTES:
is described by: ECO:0000269
product: MODEL1310110024#
reactant: MODEL1310110024#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110024#_927b770a_3c8d_4cca_a448_fa6b35455c34
has only substance units: false
is: P19174
name: PLCG1
is encoded by: hsa:5335
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
type: Species
initial concentration: NaN

metaR RE2626C
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
product: MODEL1310110024#
reactant: MODEL1310110024#
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110024#
name: RE2626

http://identifiers.org/biomodels.db/MODEL1310110024#_d865abfb_5e0d_43e5_a5eb_1abcd2877795
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is: P22413
name: ENPP1
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:5167

http://identifiers.org/biomodels.db/MODEL1310110024#_e4b3872b_9379_4b38_a176_c438e8512bef
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:AA788780
initial amount: NaN
constant: false
name: _AA788780_1_c

metaM HC01405 m
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266
initial amount: NaN
type: Species
boundary condition: false
name: (S)-Hydroxyoctanoyl-CoA
has only substance units: false
is: CHEBI:28632
is: SBO:0000247
constant: false
initial concentration: 1.0

metaM thbpt4acam c
is: CHEBI:15374
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: 4a-hydroxytetrahydrobiopterin
constant: false
is: HMDB02281
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
has only substance units: false
type: Species

metaM hdcea c
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:32372
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
is: HMDB03229
name: Hexadecenoate (n-C16:1)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110024#_f02e83dc_f637_4408_af57_3544d045c4c7
type: Species
name: NDUFA11
is: C9JT23
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:126328

http://identifiers.org/biomodels.db/MODEL1310110024#_b407e479_99e2_44e6_a919_3a73fd27da4d
is encoded by: hsa:10588
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is: P49914
type: Species
is: SBO:0000252
name: MTHFS

metaM arab L e
initial concentration: 1.0
boundary condition: false
name: L-arabinose
type: Species
constant: false
is: HMDB00646
notes: FORMULA: C5H10O5 CHARGE: 0
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:30849

metaR r0249
name: D-Ribose-5-phosphate ketol-isomerase Pentose phosphate pathway EC:5.3.1.6
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.12
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
product: MODEL1310110024#
is: SBO:0000176
reactant: MODEL1310110024#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (2592.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: PMID:14690456,PMID:14988808,PMID:15234337,PMID:2843500 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110024#_8f794aa4_383a_402c_9367_2c745408ee2b
name: _AI291895_1_c
has only substance units: false
is encoded by: hsa:AI291895
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial concentration: NaN

metaR SUCCOAPET
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of succinyl coa for release into cytosol
type: Reaction

metaR MALSO3tm
reactant: MODEL1310110024#
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is: SBO:0000185
kinetic law: MODEL1310110024#
name: Malate:sulfite antiport, mitochondrial
type: Reaction
reversible: true
fast: false
modifier: MODEL1310110024#
is described by: ECO:0000269

metaM prist x
is: HMDB00795
initial concentration: 1.0
is: CHEBI:51340
boundary condition: false
name: pristanic acid
type: Species
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
initial amount: NaN

metaM pa hs c
type: Species
is: CHEBI:57739
boundary condition: false
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
initial concentration: 1.0
constant: false
is: SBO:0000247
name: phosphatidate(2-)
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_fe2331b4_8601_4e7c_931e_8e53c0f8637d
initial amount: NaN
name: PDE1C
is: Q8NB10
is encoded by: hsa:5137
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species

metaM ahcys c
is: CHEBI:16680
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
is: SBO:0000247
constant: false
is: HMDB00939
is: C00021
initial amount: NaN
has only substance units: false
boundary condition: false
name: S-Adenosyl-L-homocysteine
type: Species
initial concentration: 1.0

metaR TAUBETAtc
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of taurine into the intestinal cells by beta transport system
type: Reaction

metaR MMMm
reversible: true
type: Reaction
product: MODEL1310110024#
name: methylmalonyl-CoA mutase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/5.4.99.2
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (4594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES:TDV
fast: false
is: SBO:0000176
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_0576011b_888c_4cd5_bbc6_827b7c718db1
constant: false
is: Q99807
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: COQ7
is encoded by: hsa:10229
is: SBO:0000252
type: Species
has only substance units: false

metaR N2M2NMASNt
product: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110024#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110024#
reversible: false
type: Reaction
name: n2m2nmasn transport, Golgi to extracellular

metaR SERGLYexR
product: MODEL1310110024#
name: L-Serine/Glycine reversible exchange
reversible: true
reactant: MODEL1310110024#
modifier: MODEL1310110024#
is described by: ECO:0000304
fast: false
type: Reaction
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185

metaR ATP2ter
name: AMP/ATP transporter, endoplasmic reticulum
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
product: MODEL1310110024#
is described by: ECO:0000000
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110024#_7582ad6a_fda8_4924_919a_e4bf9382e43e
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
is: O76082
name: SLC22A5
constant: false
initial concentration: NaN
is encoded by: hsa:6584
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_0ea30fd0_e34b_4b2e_92de_589bcd872514
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:728226
name: _728226_1_e
has only substance units: false

metaR r1492
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110024#
name: Utilized transport
reactant: MODEL1310110024#
reversible: false
product: MODEL1310110024#

metaR NACHEX27ly
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12562784 NOTES:NCD
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
modifier: MODEL1310110024#
type: Reaction
product: MODEL1310110024#

metaR TREHe
is: SBO:0000176
product: MODEL1310110024#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.2.1.28
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR
type: Reaction
fast: false
reactant: MODEL1310110024#
name: alpha,alpha-trehalase
reversible: false
modifier: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_e062977a_f7a0_4883_9535_1c21b59cc6a4
has only substance units: false
initial amount: NaN
boundary condition: true
name: CRAT
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:1384

metaM docohexcoa m
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
name: 2,4,7,10,13,16-docosahexenoylcoa
constant: false
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/24892790

metaM zym int2 r
boundary condition: false
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-20,23-24H,6,8-17H2,1-5H3/t19-,20+,23-,24+,26+,27-/m1/s1
constant: false
has only substance units: false
is: CHEBI:52386
initial concentration: 1.0
name: zymosterol intermediate 2
initial amount: NaN
is: SBO:0000247
type: Species

metaM hdcea e
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
boundary condition: false
constant: false
is: HMDB03229
is: SBO:0000247
name: Hexadecenoate (n-C16:1)
initial amount: NaN
type: Species
is: CHEBI:32372

metaM ksi pre8 g
name: keratan sulfate I biosynthesis, precursor 8
is: CHEBI:28067
has only substance units: false
initial amount: NaN
notes: FORMULA: C115H186N8O88S2X CHARGE: -3
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
constant: false

metaM arab L c
is: SBO:0000247
is: CHEBI:30849
type: Species
notes: FORMULA: C5H10O5 CHARGE: 0
constant: false
is: HMDB00646
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: L-arabinose
boundary condition: false

metaR G14T12g
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
product: MODEL1310110024#
modifier: MODEL1310110024#
is described by: ECO:0000000
kinetic law: MODEL1310110024#

metaM lanost r
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00833 EHMN_ABBREVIATION: C01724
name: lanosterol
is: CHEBI:16521
is: SBO:0000247
boundary condition: false
is: HMDB01251
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
type: Species

metaR THRASNNaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-threonine/L-asparagine Na-dependent exchange (Thr-L in)
fast: false
type: Reaction
modifier: MODEL1310110024#
reactant: MODEL1310110024#
is: SBO:0000185
reversible: false
product: MODEL1310110024#
is described by: ECO:0000269
kinetic law: MODEL1310110024#

metaR FAOXC184m
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization of (C18:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_59c37943_1d02_4ece_bc54_9f3960fcb41b
name: ACO1
has only substance units: false
initial concentration: NaN
is encoded by: hsa:48
type: Species
boundary condition: true
is: P21399
constant: false
is: SBO:0000252
initial amount: NaN

metaR CYSASNNaEx
reactant: MODEL1310110024#
is described by: ECO:0000269
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110024#
name: L-cysteine/L-asparagine Na-dependent exchange (Cys-L in)
fast: false
type: Reaction
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_8893f99a_80be_4b80_9ace_8e56e521e2ff
boundary condition: true
is encoded by: hsa:1743
is: P36957
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: DLST
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_5a671936_03be_41c4_8dd6_6f4524a49b63
is: P00558
initial concentration: NaN
is encoded by: hsa:5230
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
type: Species
initial amount: NaN
name: PGK1

metaR RE1804C
product: MODEL1310110024#
is: SBO:0000176
kinetic law: MODEL1310110024#
type: Reaction
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
reversible: true
fast: false
is described by: ECO:0000000
name: RE1804

http://identifiers.org/biomodels.db/MODEL1310110024#_16e85c27_5e66_4a48_b231_7752d820520d
initial amount: NaN
type: Species
name: ACADM
has only substance units: false
is: SBO:0000252
is encoded by: hsa:34
is: P11310
constant: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110024#_da7e4559_e647_48f9_ba22_01487ba601e1
type: Species
boundary condition: true
is: SBO:0000252
name: PLCB1
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:23236

http://identifiers.org/biomodels.db/MODEL1310110024#_9566f2cd_828c_438e_abf2_83a4bab3d331
is encoded by: hsa:AA278423
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
name: _AA278423_1_c
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_a56e74a3_9f97_4477_8153_623c5f991837
has only substance units: false
is encoded by: hsa:22305
name: _22305_2_c
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_9c9993d6_c58c_44a7_b83a_934a8f8e8b18
initial concentration: NaN
type: Species
is: B3KWF4
is encoded by: hsa:63917
boundary condition: true
constant: false
initial amount: NaN
name: GALNT11
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_01dbbebc_c54b_4306_861d_c060721413b0
constant: false
boundary condition: true
name: AK1
initial amount: NaN
has only substance units: false
is: P00568
is encoded by: hsa:203
type: Species
initial concentration: NaN
is: SBO:0000252

metaR PRPNCOAHYDm
reactant: MODEL1310110024#
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay
reversible: false
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
fast: false
name: Propenoyl-CoA hydrolase (m)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.18
product: MODEL1310110024#

metaM ahcys e
is: CHEBI:16680
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
name: S-Adenosyl-L-homocysteine
is: SBO:0000247
initial amount: NaN
is: C00021
notes: FORMULA: C14H20N6O5S CHARGE: 0
is: HMDB00939
boundary condition: false

metaR r0517
fast: false
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
is version of: http://identifiers.org/ec-code/1.17.4.1
reactant: MODEL1310110024#
product: MODEL1310110024#
reversible: true
type: Reaction
kinetic law: MODEL1310110024#
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
is described by: ECO:0000000
modifier: MODEL1310110024#
is: SBO:0000176

metaM glyclt x
boundary condition: false
is: HMDB00115
has only substance units: false
name: glycolate
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
initial amount: NaN
is: CHEBI:29805

metaM HC00250 e
constant: false
initial amount: NaN
type: Species
is: CHEBI:29919
has only substance units: false
name: hydrosulfide
initial concentration: 1.0
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
is: SBO:0000247
boundary condition: false

metaR RIBt
fast: false
product: MODEL1310110024#
type: Reaction
name: ribose transport via diffusion
is: SBO:0000185
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110024#_c7a6059f_c0d5_4be6_b30b_7fa90a0c1099
initial amount: NaN
name: ATP2B2
is encoded by: hsa:491
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
is: Q4J699

http://identifiers.org/biomodels.db/MODEL1310110024#_a1d3f0ef_69a0_4647_b8a0_abef1212ed2d
is encoded by: hsa:T83654
constant: false
type: Species
has only substance units: false
boundary condition: true
name: _T83654_1_m
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaM abt e
name: L-arabinitol
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:18403
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
is: HMDB01851

metaM eicostetcoa c
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: C16164
boundary condition: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
constant: false
type: Species
name: eicosatetranoyl coenzyme A
initial concentration: 1.0

metaM sql r
name: squalene
is: CHEBI:15440
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
is: HMDB00256
boundary condition: false
has only substance units: false
type: Species
constant: false
initial amount: NaN

metaR ETFQO
kinetic law: MODEL1310110024#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.5.5.1
product: MODEL1310110024#
modifier: MODEL1310110024#
reversible: false
name: Electron transfer flavoprotein-ubiquinone oxidoreductase
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (2110.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.5.5.1 Confidence Level: 4 AUTHORS: PMID:10444348,PMID:12049629 NOTES:TV Ruzicka F, JBC, 1977
type: Reaction
is: SBO:0000176

metaR r1769
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110024#
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110024#

metaR H2MTer U
product: MODEL1310110024#
modifier: MODEL1310110024#
type: Reaction
kinetic law: MODEL1310110024#
reversible: false
notes: GENE_ASSOCIATION: (55650.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15623507 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110024#
is: SBO:0000176
fast: false
name: H2 mannosyltransferase, endoplasmic reticulum

metaR AKGMALtm
fast: false
reversible: true
kinetic law: MODEL1310110024#
is described by: ECO:0000269
name: alpha-ketoglutarate/malate transporter
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
reactant: MODEL1310110024#
is: SBO:0000185
modifier: MODEL1310110024#
product: MODEL1310110024#
type: Reaction

metaR GALNTg
type: Reaction
name: GalNAc transferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.41
notes: GENE_ASSOCIATION: (26290.1) or (79695.1) or (2589.1) or (50614.1) or (8693.1) or (55568.2) or (114805.1) or (11226.1) or (117248.1) or (11227.1) or (55568.1) or (2590.1) or (51809.1) or (26290.1) or (79623.1) or (63917.1) or (2591.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.41 Confidence Level: 0 AUTHORS: PMID:10767557,PMID:12417297,PMID:12507512,PMID:12634319,PMID:15147861,PMID:9765313 NOTES:NCD
reactant: MODEL1310110024#
modifier: MODEL1310110024#
fast: false
reversible: false
is: SBO:0000176
product: MODEL1310110024#
is described by: ECO:0000000
kinetic law: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_09a87c46_ca2f_4a37_9b95_0d4689a6795a
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: CPT1B
type: Species
is: B7Z5T8
is encoded by: hsa:1375
boundary condition: true
constant: false
is: SBO:0000252

metaR THYOXt2
modifier: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
product: MODEL1310110024#
reversible: true
is described by: ECO:0000269
is: SBO:0000185
name: T4 transport via facilitated diffusion
type: Reaction
fast: false
kinetic law: MODEL1310110024#

metaM C02528 r
type: Species
constant: false
is: HMDB00518
initial concentration: 1.0
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
initial amount: NaN
is: CHEBI:36234
has only substance units: false
is: SBO:0000247
name: chenodeoxycholate
boundary condition: false

metaM CE5854 e
is: HMDB02710
name: gama-CEHC-glucuronide
has only substance units: false
type: Species
is: CHEBI:27485
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110024#_dfaeed9a_8ffe_4d98_a870_9799456283db
is: P09917
is: SBO:0000252
boundary condition: true
constant: false
name: ALOX5
initial concentration: NaN
is encoded by: hsa:240
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_482a45e6_fad0_4a5a_86c4_a64715c3d107
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is encoded by: hsa:92483
initial amount: NaN
name: LDHAL6B
is: Q9BYZ2

metaR OCTDECCACT
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_56332aec_e0a4_4c5e_ae07_c241a1087f07
has only substance units: false
constant: false
is encoded by: hsa:AW299740
initial concentration: NaN
name: _AW299740_1_m
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species

metaM ditp c
boundary condition: false
constant: false
name: dITP(4-)
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB03537
is: CHEBI:61382
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
type: Species

metaM ksii core2 deg6 l
is: SBO:0000247
notes: FORMULA: C44H72N4O33SX CHARGE: -1
name: keratan sulfate II (core 2-linked), degradation product 6
type: Species
initial amount: NaN
is: HMDB00143
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:12936

metaR INSTt4 2
type: Reaction
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
product: MODEL1310110024#
name: inositol transport via sodium symport
is described by: ECO:0000006
fast: false
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD

metaR RE3241R
name: RE3241
is: SBO:0000176
product: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
fast: false
reversible: false
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
type: Reaction
is described by: ECO:0000000

metaM ptth c
is: CHEBI:16753
constant: false
has only substance units: false
is: HMDB03426
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
name: pantetheine
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
boundary condition: false

metaR OMPDC
is: SBO:0000176
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 4.1.1.23 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
modifier: MODEL1310110024#
reactant: MODEL1310110024#
name: orotidine-5'-phosphate decarboxylase
kinetic law: MODEL1310110024#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.10
reversible: false
product: MODEL1310110024#
type: Reaction

metaM abt c
boundary condition: false
type: Species
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB01851
name: L-arabinitol
initial amount: NaN
is: CHEBI:18403

http://identifiers.org/biomodels.db/MODEL1310110024#_7c228769_e7ab_413a_8712_f761bbf1bb7f
initial amount: NaN
is: SBO:0000252
name: PLCE1
is: Q9P212
type: Species
initial concentration: NaN
is encoded by: hsa:51196
boundary condition: true
has only substance units: false
constant: false

metaM cs e deg2 l
is: SBO:0000247
type: Species
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 2
is: CHEBI:57455
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
is: HMDB01354
initial concentration: 1.0
constant: false

metaR 34HPPOR
product: MODEL1310110024#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.13.11.27
name: 4-Hydroxyphenylpyruvate:oxygen oxidoreductase
notes: GENE_ASSOCIATION: (3242.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.27 Confidence Level: 4 AUTHORS: NOTES:
reversible: false
fast: false
modifier: MODEL1310110024#
is described by: ECO:0000269
kinetic law: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_8e20fd34_80cb_47c3_941a_a7dddc5ad6b0
constant: false
is encoded by: hsa:51227
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: P57054
is: SBO:0000252
has only substance units: false
type: Species
name: PIGP

metaR r0512
fast: false
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.17.4.1
reactant: MODEL1310110024#
modifier: MODEL1310110024#
reversible: true
type: Reaction
is described by: ECO:0000000
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
is: SBO:0000176

metaM ei11ecoa x
notes: FORMULA: C41H68N7O17P3S CHARGE: -4
initial concentration: 1.0
type: Species
name: 11-eicosenoylcoa
initial amount: NaN
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/24892790
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110024#_f2ea99a2_c7ac_44ba_a320_c682acbbbc35
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2180
type: Species
has only substance units: false
name: ACSL1
is: P33121
initial concentration: NaN
initial amount: NaN
constant: false

metaR FATP7t
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
reversible: true
fast: false
name: fatty acid electroneutral transport
reactant: MODEL1310110024#
is described by: ECO:0000000
kinetic law: MODEL1310110024#
is: SBO:0000185
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/6.2.1.7
type: Reaction

metaR ACITL
modifier: MODEL1310110024#
reversible: false
notes: GENE_ASSOCIATION: (47.1) or (47.2) SUBSYSTEM: Citric acid cycle EC Number: 2.3.3.8 Confidence Level: 4 AUTHORS: PMID:2295639 NOTES:ATP dependent citrate lyase. Reaction is reversible in KEGG (new EC 2.3.3.8) NCD
is described by: ECO:0000000
name: ATP-Citrate lyase
kinetic law: MODEL1310110024#
fast: false
is version of: http://identifiers.org/ec-code/2.3.3.8
type: Reaction
reactant: MODEL1310110024#
is: SBO:0000176
product: MODEL1310110024#

metaR HSPGtly
fast: false
reactant: MODEL1310110024#
reversible: false
type: Reaction
product: MODEL1310110024#
kinetic law: MODEL1310110024#
is described by: ECO:0000000
name: heparan sulfate transport, extracellular to lysosome
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaM adrncoa x
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/47205480
boundary condition: false
is: C16170
has only substance units: false
type: Species
name: adrenyl coenzyme A

metaM cspg a l
type: Species
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB02183
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:36005

http://identifiers.org/biomodels.db/MODEL1310110024#_07aa95ed_01ea_4b0c_a239_dfb64e8e2022
initial concentration: NaN
is encoded by: hsa:AI934540
constant: false
type: Species
name: _AI934540_1_c
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true

metaR KSItly
name: keratan sulfate I transport, extracellular to lysosome
is described by: ECO:0000000
fast: false
product: MODEL1310110024#
reversible: false
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaR DHCRD1
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
reversible: false
reactant: MODEL1310110024#
modifier: MODEL1310110024#
name: dihydroceramide desaturase
product: MODEL1310110024#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110024#
is described by: ECO:0000269
type: Reaction

metaR r1744
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110024#
reactant: MODEL1310110024#
product: MODEL1310110024#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
kinetic law: MODEL1310110024#
reversible: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110024#_1693f644_f7c7_44d2_928a_680850c5e972
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
is: B3KT84
is encoded by: hsa:195814
name: SDR16C5
is: SBO:0000252
type: Species
initial amount: NaN

metaR CYANt
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM
is: SBO:0000185
fast: false
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
reversible: true
type: Reaction
is described by: ECO:0000000
name: Cyanide transport via diffusion (extracellular to cytosol)

http://identifiers.org/biomodels.db/MODEL1310110024#_225bd01d_df40_4739_82a9_7f51434a409c
type: Species
is: SBO:0000252
name: PLCB3
constant: false
is: G5E960
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5331
initial amount: NaN

metaR PROSTGF2t
is: SBO:0000185
reactant: MODEL1310110024#
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110024#
name: prostaglandin uniport
type: Reaction
modifier: MODEL1310110024#
fast: false
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ

metaR RE0453N
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
reversible: true
product: MODEL1310110024#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000000
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
name: RE0453
is: SBO:0000176
type: Reaction
modifier: MODEL1310110024#

metaR HDCEAtr
product: MODEL1310110024#
fast: false
is described by: ECO:0000000
name: fatty acid transport via diffusion
reactant: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110024#
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110024#_33f4a78e_5610_4208_ad4f_bccff7ff1e13
constant: false
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1798
is: Q9H3H5
name: DPAGT1

metaR UGALNACtg
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
name: UDP-GalNAc Golgi transport via CMP antiport
type: Reaction
fast: false
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
reversible: true
product: MODEL1310110024#
is described by: ECO:0000269
modifier: MODEL1310110024#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110024#_afb2fafe_5def_4096_b3b8_191e09b843f2
is encoded by: hsa:498
is: SBO:0000252
name: ATP5A1
type: Species
has only substance units: false
constant: false
boundary condition: true
is: B4DY56
initial concentration: NaN
initial amount: NaN

metaR RE2998M
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6
type: Reaction
name: RE2998
fast: false
reactant: MODEL1310110024#
reversible: false
kinetic law: MODEL1310110024#
product: MODEL1310110024#

metaR FAOXC103C102x
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_e9e2da49_1336_4656_b5a9_d87010507fbb
boundary condition: true
is encoded by: hsa:4720
initial amount: NaN
type: Species
constant: false
name: NDUFS2
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: B7Z792

metaM 34dhphe c
name: L-dopa
is: HMDB00181
is: CHEBI:15765
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H11NO4 CHARGE: 0 INCHI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
constant: false
boundary condition: false
has only substance units: false

metaR G14T20g
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110024#
kinetic law: MODEL1310110024#
is described by: ECO:0000000
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.4.1.22
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.4.1.90
reversible: false

metaR r0638
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
type: Reaction
product: MODEL1310110024#
reversible: true
is version of: http://identifiers.org/ec-code/2.8.1.2
is described by: ECO:0000000
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
modifier: MODEL1310110024#
fast: false
is: SBO:0000176

metaM ptdcacoa c
type: Species
notes: FORMULA: C36H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C36H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-27(45)64-20-19-38-26(44)17-18-39-34(48)31(47)36(2,3)22-57-63(54,55)60-62(52,53)56-21-25-30(59-61(49,50)51)29(46)35(58-25)43-24-42-28-32(37)40-23-41-33(28)43/h23-25,29-31,35,46-47H,4-22H2,1-3H3,(H,38,44)(H,39,48)(H,52,53)(H,54,55)(H2,37,40,41)(H2,49,50,51)/p-4/t25-,29-,30-,31+,35-/m0/s1
name: pentadecanoyl Coenzyme A
is: HMDB06499
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_ef418e9c_b4c6_4558_a5f6_84d5423c0ae3
name: SPTLC1:SPTLC2
has part: O15269
constant: false
is: SBO:0000297
is encoded by: hsa:10558
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:9517
has part: O15270
boundary condition: true
has only substance units: false
type: Species

metaM k c
has only substance units: false
is: HMDB00586
is: CHEBI:29103
type: Species
is: C00238
is: SBO:0000247
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
constant: false
name: potassium
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaM dec47dicoa m
name: 4,7-decadienoylcoa
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
has only substance units: false
is: SBO:0000247
type: Species

metaR RE0453M
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
product: MODEL1310110024#
is described by: ECO:0000000
name: RE0453
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110024#
fast: false
is: SBO:0000176
type: Reaction
reversible: true
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_d1af6323_13e9_4db3_a8a9_6e2ad49cdb33
initial concentration: NaN
is encoded by: hsa:4668
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
name: NAGA
is: P17050
boundary condition: true

metaR PSERT
product: MODEL1310110024#
reactant: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: (29968.1) or (29968.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.52 Confidence Level: 4 AUTHORS: PMID:12633500 NOTES:
is: SBO:0000176
fast: false
kinetic law: MODEL1310110024#
is described by: ECO:0000269
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.6.1.52
reversible: false
name: phosphoserine transaminase

metaM Tn antigen l
notes: FORMULA: C8H14NO5X CHARGE: 0
constant: false
is: C04383
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
name: Tn antigen

http://identifiers.org/biomodels.db/MODEL1310110024#_cbe20e0d_de9b_46f6_8fcf_b0077244061d
is encoded by: hsa:2936
name: GSR
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
is: P00390
initial amount: NaN
constant: false

metaM tetd7ecoa m
has only substance units: false
is: HMDB13109
constant: false
name: 7-tetradecenoylcoa
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110024#_50072ae8_2667_4581_9cf1_c7467545899d
is encoded by: hsa:4712
name: NDUFB6
constant: false
initial concentration: NaN
boundary condition: true
is: Q5VYT2
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN

metaR EX 10fthf7glu LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](7) exchange
type: Reaction

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

metaR RE2625M
is described by: ECO:0000000
name: RE2625
product: MODEL1310110024#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
modifier: MODEL1310110024#
reversible: true
is version of: http://identifiers.org/ec-code/1.14.13.15
fast: false
type: Reaction
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#

metaR FAOXTC182TC162m
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C18:2-->C16:2)m
type: Reaction

metaR FAOXOHC16C16DCc
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(w-OHC16-->C16DC)c
type: Reaction

metaR RE1518M
is: SBO:0000176
reactant: MODEL1310110024#
product: MODEL1310110024#
kinetic law: MODEL1310110024#
name: RE1518
reversible: true
modifier: MODEL1310110024#
fast: false
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.13
is version of: http://identifiers.org/ec-code/1.3.3.6
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:

metaM 34dhphe e
has only substance units: false
name: L-dopa
is: HMDB00181
is: CHEBI:15765
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C9H11NO4 CHARGE: 0 INCHI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
boundary condition: false

metaM apoC Lys c
is: CHEBI:32551
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB00182
has only substance units: false
notes: FORMULA: C6H13N2OX CHARGE: 0
name: Apocarboxylase (Lys residue)
type: Species
is: SBO:0000247

metaR DADNt4
kinetic law: MODEL1310110024#
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
reactant: MODEL1310110024#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
fast: false
name: deoxyadenosine transport via diffusion
type: Reaction

metaR 34HPPte
fast: false
is: SBO:0000185
reactant: MODEL1310110024#
product: MODEL1310110024#
kinetic law: MODEL1310110024#
is described by: ECO:0000134
reversible: true
name: Transport of 3-(4-hydroxyphenyl)pyruvate
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaM cl e
name: Chloride
initial concentration: 1.0
has only substance units: false
notes: FORMULA: Cl CHARGE: -1
is: C00115
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB00492
constant: false
boundary condition: false
is: CHEBI:3966

metaM icit m
has only substance units: false
is: SBO:0000247
is: HMDB00193
boundary condition: false
is: C00311
name: Isocitrate
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16087
constant: false
type: Species
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311

metaR CYTK6n
reactant: MODEL1310110024#
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
is: SBO:0000176
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
kinetic law: MODEL1310110024#
is described by: ECO:0000269
fast: false
name: cytidylate kinase (CMP,CTP),nuclear

metaR r0633
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
type: Reaction
modifier: MODEL1310110024#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.7.7.3
fast: false
is: SBO:0000176
kinetic law: MODEL1310110024#
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:

metaM dmhptcrn e
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
boundary condition: false
is: HMDB06320
constant: false
name: 2,6 dimethylheptanoyl carnitine
has only substance units: false
initial concentration: 1.0

metaM mi1p D c
is: SBO:0000247
type: Species
is: CHEBI:58433
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
name: 1D-myo-inositol 1-phosphate(2-)
initial amount: NaN
is: HMDB02985

http://identifiers.org/biomodels.db/MODEL1310110024#_d93845ab_1323_4942_9d4a_59fb6e776229
has only substance units: false
name: EHHADH
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1962
is: Q9NY65
boundary condition: true
type: Species

metaM man l
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
boundary condition: false
is: CHEBI:16024
name: D-mannose
constant: false
has only substance units: false
is: HMDB00169
initial concentration: 1.0
type: Species
initial amount: NaN

metaR ACETONEt2
reversible: true
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
reactant: MODEL1310110024#
name: acetone transport via proton symport
product: MODEL1310110024#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110024#
is: SBO:0000185
fast: false

metaR DCYTt
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is described by: ECO:0000000
fast: false
name: deoxycytidine transport via diffusion
kinetic law: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_c97abd9e_f7c6_4867_b8d4_fe2091d69d5a
is: O00476
is encoded by: hsa:10786
has only substance units: false
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: SLC17A3

metaR NACHEX2ly
reactant: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
kinetic law: MODEL1310110024#
is described by: ECO:0000000
reversible: false
type: Reaction
product: MODEL1310110024#

metaR THCHOLSTOICtm
type: Reaction
product: MODEL1310110024#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
fast: false
kinetic law: MODEL1310110024#
name: lipid, flip-flop intracellular transport
reactant: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_ac745d63_37cc_4a99_89e4_8cf38c4400c9
type: Species
name: PISD
is: Q9UG56
has only substance units: false
is: SBO:0000252
is encoded by: hsa:23761
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

metaR CHSTEROLt3
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
type: Reaction
name: cholesterol intracellular transport
fast: false
product: MODEL1310110024#
reversible: true
kinetic law: MODEL1310110024#

metaR C180CPT2
modifier: MODEL1310110024#
reversible: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TV
is: SBO:0000176
fast: false
name: carnitine O-stearoyl transferase
type: Reaction
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110024#
is described by: ECO:0000269
reactant: MODEL1310110024#

metaR r2318
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000185
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110024#_ecd22c73_95eb_4a00_aeaa_efb6ba09f6ca
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:C7orf24
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
name: _C7orf24_1_m

metaR SBCOAACOTx
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of suberyl coa for release into cytosol
type: Reaction

metaR r0634
reactant: MODEL1310110024#
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
type: Reaction
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is version of: http://identifiers.org/ec-code/3.1.4.1
fast: false
is described by: ECO:0000000
modifier: MODEL1310110024#
reversible: true
kinetic law: MODEL1310110024#
product: MODEL1310110024#
is: SBO:0000176

metaR GALASE19ly
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000269
reactant: MODEL1310110024#
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
reversible: false
fast: false
product: MODEL1310110024#
kinetic law: MODEL1310110024#

metaR CITt4 2
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
is: SBO:0000185
product: MODEL1310110024#
is described by: ECO:0000269
modifier: MODEL1310110024#
fast: false
reactant: MODEL1310110024#
name: citrate transport via sodium symport
kinetic law: MODEL1310110024#
type: Reaction
reversible: true

metaM L2aadp6sa c
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
is: HMDB01263
name: L-allysine
boundary condition: false
constant: false
is: CHEBI:17917
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaM aprgstrn e
initial concentration: 1.0
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12-13,16-19,22H,4-11H2,1-3H3/t13-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C04042
boundary condition: false
constant: false
is: CHEBI:28453
type: Species
initial amount: NaN
name: (20S)-20-hydroxypregn-4-en-3-one
is: HMDB03069
is: SBO:0000247
has only substance units: false

metaR AMPTASECG
name: alanyl aminopeptidase (cys-gly)
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.11.2
notes: GENE_ASSOCIATION: (290.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.1 Confidence Level: 1 AUTHORS: PMID:12675513 NOTES:SAB. activity measured in cytosol rat liver; IT IS leucine aminopeptidase (EC3.4.11.1) NOT alanyl aminopeptidase EC3.4.11.2 which shows > 80% of the activity; sequence homology rat-human not yet verified; annotation 'extracellular' under B column ERROR
modifier: MODEL1310110024#
is described by: ECO:0000212
product: MODEL1310110024#
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
reversible: false
is: SBO:0000176

metaM 3ohdcoa m
is: HMDB06402
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
initial concentration: 1.0
has only substance units: false
is: CHEBI:57349
constant: false
boundary condition: false
name: 3-oxopalmitoyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110024#_178ac140_f54f_4411_b00b_85ed64a2ca99
is encoded by: hsa:AV717590
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
name: _AV717590_1_c
type: Species

metaR r2319
is: SBO:0000185
reactant: MODEL1310110024#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
reversible: true
kinetic law: MODEL1310110024#
type: Reaction
product: MODEL1310110024#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR C180CPT1
notes: GENE_ASSOCIATION: (1375.4) or (1375.2) or (126129.1) or (1375.1) or (1374.1) or (1375.3) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TV (see C160CRN)
reversible: false
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110024#
type: Reaction
modifier: MODEL1310110024#
fast: false
name: production of stearoylcarnitine
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110024#

metaR CHSTEROLt2
reactant: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is: SBO:0000185
fast: false
kinetic law: MODEL1310110024#
name: cholesterol intracellular transport
product: MODEL1310110024#
reversible: true
is described by: ECO:0000000

metaR EX Rtotal3 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 3 position exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_19b2e406_60ee_4a1c_b573_22fca948c0a2
is: SBO:0000252
is encoded by: hsa:AI469183
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
name: _AI469183_1_x
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_3451d33e_88fb_4aeb_9882_b6a205f3dc19
boundary condition: true
name: NT5C2
type: Species
constant: false
initial concentration: NaN
is: P49902
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:22978
has only substance units: false

metaR TYMSULT
fast: false
product: MODEL1310110024#
type: Reaction
name: Tyramine Sulfotransferase
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (6818.3) or (6818.1) or (6817.4) or (6817.1) or (6817.3) or (6818.2) or (6817.2) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:TV/RS (6/14/05)
is: SBO:0000176
kinetic law: MODEL1310110024#
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/2.8.2.1
modifier: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_2f2d3fbe_1154_4ae0_89dc_5c9b11d099c7
boundary condition: true
has only substance units: false
is encoded by: hsa:1717
type: Species
is: Q9UBM7
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: DHCR7

metaM acgal l
is: HMDB00212
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
name: N-acetyl-D-galactosamine
is: CHEBI:28037
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_2baaf906_37d1_4e43_acf8_c986bcbb7c5d
boundary condition: true
is: Q8TCT1
type: Species
initial concentration: NaN
initial amount: NaN
name: PHOSPHO1
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:162466

metaR r2316
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110024#
fast: false
reversible: true
type: Reaction
product: MODEL1310110024#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110024#

metaR SERtN1
is: SBO:0000185
modifier: MODEL1310110024#
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false
name: Serine transport (Na, H coupled)
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
reversible: true
is described by: ECO:0000269
type: Reaction
product: MODEL1310110024#

metaR CHSTEROLt1
reversible: true
fast: false
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?
is: SBO:0000185
kinetic law: MODEL1310110024#
name: cholesterol intracellular transport
type: Reaction
product: MODEL1310110024#
modifier: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000304

metaR DIDPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
reversible: true
type: Reaction
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
product: MODEL1310110024#
is described by: ECO:0000000
fast: false
name: dIDP nuclear transport

metaR RE3218C
type: Reaction
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.1.6.2
is: SBO:0000176
name: RE3218
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
reactant: MODEL1310110024#
is described by: ECO:0000000
modifier: MODEL1310110024#
fast: false
reversible: true
kinetic law: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_b7a1f5fd_72ab_4c02_8868_146bd4734ef4
is encoded by: hsa:1621
boundary condition: true
is: P09172
constant: false
name: DBH
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false

metaR NACHEX15ly
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110024#
is described by: ECO:0000000
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
reactant: MODEL1310110024#
fast: false
kinetic law: MODEL1310110024#
product: MODEL1310110024#

metaR CITt4 4
is: SBO:0000185
name: citrate transport via sodium symport
kinetic law: MODEL1310110024#
reversible: true
product: MODEL1310110024#
type: Reaction
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
is described by: ECO:0000006
reactant: MODEL1310110024#
fast: false

metaR RE1845X
fast: false
name: RE1845
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.65
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
modifier: MODEL1310110024#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 1 h[c] from compEHMN reaction as they were not necessary

metaM aprgstrn c
boundary condition: false
type: Species
constant: false
name: (20S)-20-hydroxypregn-4-en-3-one
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:28453
initial concentration: 1.0
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12-13,16-19,22H,4-11H2,1-3H3/t13-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C04042
is: HMDB03069

http://identifiers.org/biomodels.db/MODEL1310110024#_5c045f1d_3a39_4192_b78a_ce04e1910eb5
has part: Q9NS82
is encoded by: hsa:56301
initial concentration: NaN
has part: P08195
is: SBO:0000297
name: SLC7A10:SLC3A2
is encoded by: hsa:6520
initial amount: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false

metaM gluala e
is: C03740
boundary condition: false
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/6503
is: HMDB06248
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740
name: 5-L-Glutamyl-L-alanine
type: Species
initial concentration: 1.0

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

metaR r2317
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
kinetic law: MODEL1310110024#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110024#

metaM HC01434 m
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
name: oxalatosuccinate(3-)
has only substance units: false
boundary condition: false
is: CHEBI:58931

http://identifiers.org/biomodels.db/MODEL1310110024#_2af2ac38_f061_43d4_bec1_bd94cbff9c2d
initial concentration: NaN
is: Q9BV79
type: Species
constant: false
name: MECR
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:51102
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110024#_3d2ed36d_12f9_4bd2_af9d_3df32d70bd25
is encoded by: hsa:2182
type: Species
is: Q5JWV8
initial amount: NaN
constant: false
name: ACSL4
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false

metaM k e
constant: false
is: SBO:0000247
name: potassium
initial concentration: 1.0
is: CHEBI:29103
is: HMDB00586
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
is: C00238

http://identifiers.org/biomodels.db/MODEL1310110024#_fb4ab633_d1ba_4683_a88a_28ad308180ad
constant: false
is: SBO:0000252
is: Q6FHI7
is encoded by: hsa:762
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
name: CA4
initial amount: NaN

metaM dd5ecoa m
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB13028
initial concentration: 1.0
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
is: C01942
constant: false
initial amount: NaN
type: Species
name: 5-dodecenoylcoa

metaR FRDPtr
name: lipid, flip-flop intracellular transport
reactant: MODEL1310110024#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reversible: true

metaR ALAASNNaEx
reactant: MODEL1310110024#
reversible: false
is: SBO:0000185
name: L-alanine/L-asparagine Na-dependent exchange (Ala-L in)
type: Reaction
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110024#
fast: false
modifier: MODEL1310110024#
product: MODEL1310110024#
is described by: ECO:0000269

metaM inost e
name: myo-inositol
is: HMDB00211
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
is: CHEBI:17268

metaR DNDPt28m
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110024#
fast: false
name: dCDP transport via dGDP antiport
is: SBO:0000185
modifier: MODEL1310110024#
type: Reaction
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110024#

metaR DOLPH Ler
product: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.3.51 Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110024#
type: Reaction
name: Dolichol-phosphate phosphohydrolase, human (liver)

metaM grdp x
is: CHEBI:58057
notes: FORMULA: C10H17O7P2 CHARGE: -3 INCHI: InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/p-3/b10-7+ HEPATONET_1.0_ABBREVIATION: HC00288 EHMN_ABBREVIATION: C00341
name: geranyl diphosphate(3-)
boundary condition: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
is: HMDB01285
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_745ad0bf_e906_4263_abc8_2f7a8228f229
is encoded by: hsa:64850
has only substance units: false
name: AGXT2L1
type: Species
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: Q8TBG4

http://identifiers.org/biomodels.db/MODEL1310110024#_499ef41a_ec08_4cd3_ab1b_465a2b502b28
boundary condition: true
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:226
is: SBO:0000252
name: ALDOA
is: P04075
initial amount: NaN

metaM apoC Lys m
type: Species
initial amount: NaN
notes: FORMULA: C6H13N2OX CHARGE: 0
constant: false
boundary condition: false
name: Apocarboxylase (Lys residue)
is: HMDB00182
is: SBO:0000247
is: CHEBI:32551
initial concentration: 1.0
has only substance units: false

metaM 5adtststerone r
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
initial amount: NaN
is: HMDB02961
name: 17beta-hydroxy-5alpha-androstan-3-one
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:16330
constant: false
initial concentration: 1.0
type: Species

metaM prgstrn e
has only substance units: false
is: HMDB01830
is: SBO:0000247
boundary condition: false
name: progesterone
initial concentration: 1.0
type: Species
is: CHEBI:17026
notes: FORMULA: C21H30O2 CHARGE: 0 INCHI: InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C00410
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_c07a0963_91fa_4380_a231_22c10f37c012
boundary condition: true
constant: false
initial concentration: NaN
name: GCH1
has only substance units: false
is: SBO:0000252
is: Q8IZH9
initial amount: NaN
type: Species
is encoded by: hsa:2643

metaM 4nph e
is: SBO:0000247
is: HMDB01232
has only substance units: false
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
type: Species
is: CHEBI:57917
initial amount: NaN
constant: false
name: 4-nitrophenolate
initial concentration: 1.0
boundary condition: false

metaR C181CPT1
is: SBO:0000176
name: transport of Octadecenoyl-CoA into mitochondrial matrix
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
fast: false
reactant: MODEL1310110024#
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
is described by: ECO:0000269
reversible: false
product: MODEL1310110024#
kinetic law: MODEL1310110024#

metaR r0630
reactant: MODEL1310110024#
reversible: true
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.1.3.2
is described by: ECO:0000000
type: Reaction
product: MODEL1310110024#
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
is version of: http://identifiers.org/ec-code/3.1.3.1
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110024#_85499c10_fb7b_42f1_8a7d_46a756c0e5a5
type: Species
initial concentration: NaN
name: NME1:NME2
initial amount: NaN
is: SBO:0000297
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:4830

http://identifiers.org/biomodels.db/MODEL1310110024#_d63e6292_9383_4c62_8682_8ed4ee44f4dc
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is: O75874
is: SBO:0000252
name: IDH1
is encoded by: hsa:3417
initial concentration: NaN
constant: false

metaM mi1p D n
initial amount: NaN
is: HMDB02985
is: CHEBI:58433
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
type: Species
name: 1D-myo-inositol 1-phosphate(2-)
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_cf008cb8_f0f7_4355_96af_6d4ff92c3928
is encoded by: hsa:4514
has part: P13073
has part: P09669
is: SBO:0000297
is encoded by: hsa:1351
has part: Q7Z4L0
constant: false
has part: H0UI06
is encoded by: hsa:341947
has part: P15954
is encoded by: hsa:84701
has part: Q8TF08
has part: Q96KJ9
is encoded by: hsa:1350
boundary condition: true
has part: P24311
is encoded by: hsa:4513
is encoded by: hsa:9167
has part: Q7GXZ8
is encoded by: hsa:1340
is encoded by: hsa:1346
has part: Q7GXY8
has part: P12074
has part: P20674
is encoded by: hsa:170712
has only substance units: false
is encoded by: hsa:1327
has part: P14854
is encoded by: hsa:1349
has part: Q02221
has part: Q6YFQ2
initial amount: NaN
type: Species
has part: P00414
is encoded by: hsa:4512
is encoded by: hsa:1337
initial concentration: NaN
is encoded by: hsa:1345
has part: Q6FGA0
is encoded by: hsa:125965
is encoded by: hsa:1339
is encoded by: hsa:1347
has part: Q53XN1
is encoded by: hsa:1329
has part: Q53YB7
is encoded by: hsa:9377
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
has part: P24310

http://identifiers.org/biomodels.db/MODEL1310110024#_85958bdb_f871_4cb7_b3df_f638b788f6d1
boundary condition: true
initial concentration: NaN
is: Q9NS00
constant: false
is encoded by: hsa:56913
has only substance units: false
name: C1GALT1
is: SBO:0000252
type: Species
initial amount: NaN

metaR SCP22x
is version of: http://identifiers.org/ec-code/2.3.1.176
fast: false
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
reversible: true
reactant: MODEL1310110024#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110024#
product: MODEL1310110024#
modifier: MODEL1310110024#
name: Sterol carrier protein 2

metaR METtec
modifier: MODEL1310110024#
product: MODEL1310110024#
reversible: true
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
is described by: ECO:0000269
name: L-methionine transport via diffusion (extracellular to cytosol)
type: Reaction
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110024#_98255c90_44a7_45aa_b7bf_b7b7596d81eb
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: Q3I5F7
name: ACOT6
type: Species
has only substance units: false
is encoded by: hsa:641372
constant: false

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

metaR r0743
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: false
is: SBO:0000176
name: hydroxysteroid (17-beta) dehydrogenase 4 Bile acid biosynthesis EC:1.1.1.35
fast: false
type: Reaction
kinetic law: MODEL1310110024#
product: MODEL1310110024#
modifier: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_4ee75144_20d8_419d_b9ee_c8124c80eb76
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5279
initial amount: NaN
name: PIGC
initial concentration: NaN
type: Species
has only substance units: false
constant: false

metaR AHC
is: SBO:0000176
kinetic law: MODEL1310110024#
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.3.1.1
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (191.1) or (10768.2) or (10768.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 3.3.1.1 Confidence Level: 4 AUTHORS: PMID:12590576,PMID:2596825 NOTES:
product: MODEL1310110024#
fast: false
name: adenosylhomocysteinase
type: Reaction
reactant: MODEL1310110024#

metaM retn e
name: all-trans-retinoate
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
boundary condition: false
is: CHEBI:35291
has only substance units: false
type: Species
initial amount: NaN
is: HMDB01852
is: SBO:0000247
initial concentration: 1.0
constant: false

metaR PRO1xm
reversible: false
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000254
fast: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.99.8
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:NCD
name: proline oxidase (NAD), mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110024#_374aa47c_be3e_4483_bebe_49108448aa96
initial concentration: NaN
is: Q9H2X9
boundary condition: true
constant: false
is encoded by: hsa:57468
has only substance units: false
is: SBO:0000252
type: Species
name: SLC12A5
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_dfc18444_934b_4bcd_b89b_5f3c8a7bbcc9
type: Species
is encoded by: hsa:2530
initial amount: NaN
name: FUT8
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: Q9BYC5

metaR AKGDm
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110024#
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.2.4.2
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.61
fast: false
name: 2-oxoglutarate dehydrogenase
notes: GENE_ASSOCIATION: (4967.2) and (1738.1 and 8050.1) and (1743.1) or (4967.1) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Citric acid cycle EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:1542694 NOTES:EC taken from Ligand TV. Genetic
is: SBO:0000176
modifier: MODEL1310110024#
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.8.1.4

metaR ADPtx
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
reversible: true
product: MODEL1310110024#
fast: false
kinetic law: MODEL1310110024#
name: ADP transporter, peroxisomal
type: Reaction
is: SBO:0000185
reactant: MODEL1310110024#

metaR VLCSp
is: SBO:0000176
name: Very-long-chain-fatty-acid-CoA ligase
reversible: false
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
modifier: MODEL1310110024#
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#

metaR PTDCACRNt
reversible: false
is: SBO:0000185
reactant: MODEL1310110024#
product: MODEL1310110024#
modifier: MODEL1310110024#
name: pentadecanoate transport into the mitochondria
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ
kinetic law: MODEL1310110024#
type: Reaction

metaR C4tcx
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of bytyrylcarnitine from peroxisomes
type: Reaction

metaR GLCNACT U
fast: false
product: MODEL1310110024#
name: UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase (uterus)
reversible: false
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.141 Confidence Level: 0 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110024#_fdc82160_326a_4fdf_9a84_2225dd077a97
is: SBO:0000252
is: Q9NPC4
constant: false
type: Species
has only substance units: false
is encoded by: hsa:53947
name: A4GALT
boundary condition: true
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_22979344_30c7_4ae7_a6ec_e9ee38c23689
constant: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: _R06874_1_r
is encoded by: hsa:R06874
is: SBO:0000252

metaR S6TASE11ly
is: SBO:0000176
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
name: N-acetylglucosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.14
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110024#
type: Reaction
fast: false
reactant: MODEL1310110024#
product: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_5c07d0ff_ecde_4c28_9828_5695b8ebe9f1
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:9091
is: B2RAU6
name: PIGQ
boundary condition: true

metaM prgstrn c
name: progesterone
initial amount: NaN
initial concentration: 1.0
is: HMDB01830
has only substance units: false
is: CHEBI:17026
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C21H30O2 CHARGE: 0 INCHI: InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C00410
type: Species

metaM 4nph c
has only substance units: false
is: SBO:0000247
is: HMDB01232
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
type: Species
is: CHEBI:57917
name: 4-nitrophenolate
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false

metaM ipdp x
initial concentration: 1.0
boundary condition: false
is: CHEBI:128769
has only substance units: false
constant: false
name: isopentenyl diphosphate(3-)
is: HMDB01347
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129

metaM ksii core4 pre5 g
notes: FORMULA: C69H112N6O48X CHARGE: -1
name: keratan sulfate II biosynthesis, precursor 5
initial amount: NaN
is: CHEBI:58053
constant: false
initial concentration: 1.0
has only substance units: false
is: C00130
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB00175

metaR CSBPASEly
is: SBO:0000176
name: chondroitin sulfate B proteoglycan protease, lysosome (endosome)
reversible: false
fast: false
product: MODEL1310110024#
is described by: ECO:0000000
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
kinetic law: MODEL1310110024#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_b30b88af_ef1f_472c_8233_3f75fd0219a6
initial amount: NaN
is: P15531
type: Species
is: SBO:0000252
is encoded by: hsa:4830
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
name: NME1

metaM retn c
type: Species
is: SBO:0000247
is: CHEBI:35291
name: all-trans-retinoate
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB01852
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777

metaM acgpail hs c
boundary condition: false
notes: FORMULA: C17H29NO14PFULLRCO2FULLR2CO2 CHARGE: -1 EHMN_ABBREVIATION: C01288
has only substance units: false
is: CHEBI:57265
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(1-)
constant: false

metaR EX HC02202 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin A1(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_49fb1054_0ec8_4ac1_ac8d_75d1d677606d
type: Species
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2180
name: ACSL1
is: P33121
is: SBO:0000252

metaR PHEt4
notes: GENE_ASSOCIATION: (54407.1) or (84889.1) or (11254.1) or (6542.1) or (81539.1) or (6541.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
is described by: ECO:0000269
reactant: MODEL1310110024#
reversible: false
name: L-phenylalanine transport in via sodium symport
fast: false
product: MODEL1310110024#
modifier: MODEL1310110024#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_3e61ddf1_68b3_4f72_8667_0d1f3c14c3e7
has only substance units: false
type: Species
is encoded by: hsa:6307
name: MSMO1
is: A8MYF6
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN

metaM xol7ah2 c
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
name: 5beta-cholestane-3alpha,7alpha-diol
is: HMDB06893
is: CHEBI:28047
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR KSII CORE4t
is: SBO:0000185
is described by: ECO:0000000
name: keratan sulfate II (core4) transport, golgi to extracellular
reactant: MODEL1310110024#
reversible: false
kinetic law: MODEL1310110024#
fast: false
type: Reaction
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaM dmhptcrn m
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
name: 2,6 dimethylheptanoyl carnitine
initial concentration: 1.0
type: Species
is: HMDB06320

metaM glx x
initial amount: NaN
name: glyoxylate
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
constant: false
is: HMDB00119
is: CHEBI:36655

metaR BAMPPALDOX
is described by: ECO:0000212
name: beta-Aminopropion aldehyde:NAD+ oxidoreductase
modifier: MODEL1310110024#
type: Reaction
reactant: MODEL1310110024#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.36
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
reversible: false
notes: GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.36 Confidence Level: 1 AUTHORS: PMID:12586697 NOTES:SAB
kinetic law: MODEL1310110024#
product: MODEL1310110024#

metaM 5tedtricoa x
is: HMDB02288
name: 5,8,11-tetradecatrienoylcoa
has only substance units: false
type: Species
constant: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaM m7mpdol L r
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
constant: false
is: CHEBI:37636
initial amount: NaN
name: (alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
boundary condition: false
notes: FORMULA: C1720H2828N20O570P20 CHARGE: -20

http://identifiers.org/biomodels.db/MODEL1310110024#_c005d0ab_d299_4826_a947_c4953d8217f3
type: Species
name: NME7
constant: false
is encoded by: hsa:29922
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110024#_67fc13c8_5eb4_447d_86f4_9911bae24e4d
initial amount: NaN
is: P24310
boundary condition: true
name: COX7A1
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1346
type: Species
has only substance units: false
constant: false

metaM c4dc e
name: succinyl carnitine
type: Species
has only substance units: false
is: C02862
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/213144
is: HMDB02013
initial concentration: 1.0
notes: FORMULA: C11H18NO6 CHARGE: -1
constant: false

metaM tdcoa c
name: Tetradecanoyl-CoA (n-C14:0CoA)
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB01521
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:57385
constant: false
is: C02593

metaR EX 3octdece1crn
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-octadecenoyl carnitine
type: Reaction

metaM m2mn l
initial concentration: 1.0
is: HMDB06537
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C26H45NO21 CHARGE: 0 INCHI: InChI=1/C26H45NO21/c1-6(32)27-11-15(36)20(10(5-31)42-23(11)41)46-25-18(39)22(14(35)8(3-29)44-25)48-26-19(40)21(13(34)9(4-30)45-26)47-24-17(38)16(37)12(33)7(2-28)43-24/h7-26,28-31,33-41H,2-5H2,1H3,(H,27,32)/t7-,8-,9-,10+,11+,12-,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23+,24-,25+,26+/m0/s1
is: SBO:0000247
type: Species
boundary condition: false
name: (alpha-D-mannosyl)2-beta-D-mannosyl-N-acetylglucosamine

metaM dolglcp L r
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:15812
constant: false
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
initial amount: NaN
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
boundary condition: false

metaM c4dc c
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C11H18NO6 CHARGE: -1
initial amount: NaN
is: HMDB02013
type: Species
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/213144
name: succinyl carnitine
initial concentration: 1.0
is: C02862

metaR AMETtd
name: diffusion of S-Adenosyl-L-methionine
product: MODEL1310110024#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110024#
is: SBO:0000185
reactant: MODEL1310110024#
is described by: ECO:0000134
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_609896f6_d776_476d_bfea_4fa5e8756fd0
is: SBO:0000252
has only substance units: false
constant: false
name: _T83654_1_c
initial amount: NaN
type: Species
is encoded by: hsa:T83654
boundary condition: true
initial concentration: NaN

metaM xol7ah3 m
boundary condition: false
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
constant: false
name: 5beta-cholestane-3alpha,7alpha,26-triol
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB12455
is: CHEBI:28540

metaR C4x
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: esterification of butyrylcoa to butyrylcarnitine for transport
type: Reaction

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

metaM m5masnB2 g
is: HMDB02985
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C52H87N2O40X CHARGE: 0
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:58433
constant: false
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: SBO:0000247

metaR PROSTGE1t
product: MODEL1310110024#
name: prostaglandin transport via bicarbonate countertransport
is: SBO:0000185
type: Reaction
modifier: MODEL1310110024#
reversible: true
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
reactant: MODEL1310110024#
is described by: ECO:0000269
kinetic law: MODEL1310110024#
fast: false

metaR EX HC02206 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin C1(1-) exchange
type: Reaction

metaR DOLPMT2 Ler
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
is described by: ECO:0000000
fast: false
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
product: MODEL1310110024#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#

metaM HC01434 x
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
is: CHEBI:58931
initial concentration: 1.0
name: oxalatosuccinate(3-)
constant: false

metaM acgal c
boundary condition: false
is: CHEBI:28037
is: HMDB00212
type: Species
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: N-acetyl-D-galactosamine
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_b0c6e882_2f36_415c_b153_3ab6773540d7
constant: false
initial amount: NaN
boundary condition: true
name: GMPR2
is encoded by: hsa:51292
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: Q86T14

http://identifiers.org/biomodels.db/MODEL1310110024#_c3d4b0f8_e0e3_4bbc_b3fe_de2c2b7a5542
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:80347
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
type: Species
name: COASY
is: Q13057

metaM dcsptn1coa x
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205483
is: SBO:0000247
is: C16173
initial amount: NaN
is: HMDB06513
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110024#_c7b9025b_5257_486c_b92f_27919c78fe9d
is encoded by: hsa:125965
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: COX6B2
type: Species
constant: false
initial amount: NaN
is: Q6YFQ2

http://identifiers.org/biomodels.db/MODEL1310110024#_689cc661_2672_4bc7_90cb_2409a962a208
is: O75610
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:10637
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
name: LEFTY1

http://identifiers.org/biomodels.db/MODEL1310110024#_1f3e3819_a02c_4efe_aa8e_7770d84a5601
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
name: _AA532636_1_m
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:AA532636

metaM inost c
is: CHEBI:17268
has only substance units: false
is: HMDB00211
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: myo-inositol

http://identifiers.org/biomodels.db/MODEL1310110024#_5965e18e_089c_4128_b011_0419708fe5d7
boundary condition: true
type: Species
initial concentration: NaN
constant: false
has only substance units: false
name: RDH13
is: SBO:0000252
is encoded by: hsa:112724
initial amount: NaN
is: B3KVA3

metaR EX succ LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Succinate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_bd81faa5_7f80_48af_b91f_57fd67d50cd2
is: Q14032
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:570
boundary condition: true
name: BAAT
type: Species
is: SBO:0000252

metaM tdchola e
is: HMDB00951
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:9407
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
name: taurochenodeoxycholate
type: Species

metaM CE0785 m
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
name: cis,cis-myristo-5,8-dienoyl-CoA
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
constant: false
is: CHEBI:57795

http://identifiers.org/biomodels.db/MODEL1310110024#_a71b182d_bb88_4530_a9fc_3882fb0d034b
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:11212
has only substance units: false
name: PROSC
is: O94903
type: Species
initial amount: NaN

metaM ksi pre26 g
is: CHEBI:28067
notes: FORMULA: C199H318N14O166S8X CHARGE: -9
boundary condition: false
constant: false
name: keratan sulfate I biosynthesis, precursor 26
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0

metaR LTA4H
reversible: false
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110024#
is: SBO:0000176
modifier: MODEL1310110024#
fast: false
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.3.2.6
notes: GENE_ASSOCIATION: (4048.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 3.3.2.6 Confidence Level: 4 AUTHORS: PMID:7918238 NOTES:NJ
product: MODEL1310110024#
name: Leukotriene A-4 hydrolase

metaR ACGALtly
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
fast: false
product: MODEL1310110024#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110024#
reversible: false
type: Reaction
name: N-acetyl-galactosamine lysosomal efflux

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

metaR r0744
reversible: false
reactant: MODEL1310110024#
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110024#
name: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl- CoA hydro-lyase Bile acid biosynthesis EC:4.2.1.107
is: SBO:0000176
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 4.2.1.107 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:

metaR r0885
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
type: Reaction
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/1.3.1.38
is: SBO:0000185
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
fast: false
product: MODEL1310110024#

metaR FAOXC15C13m
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C15-->C13)m
type: Reaction

metaM L2aadp6sa m
constant: false
is: SBO:0000247
is: CHEBI:17917
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
is: HMDB01263
name: L-allysine
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110024#_63130d30_f98e_4e5d_9c53_4184c79a44b4
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:518
boundary condition: true
initial amount: NaN
name: ATP5G3
is: SBO:0000252

metaM ptdcacoa m
notes: FORMULA: C36H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C36H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-27(45)64-20-19-38-26(44)17-18-39-34(48)31(47)36(2,3)22-57-63(54,55)60-62(52,53)56-21-25-30(59-61(49,50)51)29(46)35(58-25)43-24-42-28-32(37)40-23-41-33(28)43/h23-25,29-31,35,46-47H,4-22H2,1-3H3,(H,38,44)(H,39,48)(H,52,53)(H,54,55)(H2,37,40,41)(H2,49,50,51)/p-4/t25-,29-,30-,31+,35-/m0/s1
initial amount: NaN
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
name: pentadecanoyl Coenzyme A
is: HMDB06499
is: SBO:0000247

metaM man r
boundary condition: false
name: D-mannose
has only substance units: false
is: CHEBI:16024
constant: false
is: HMDB00169
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110024#_9a207bdb_d4e4_4875_9837_f4ef6e9479ec
is encoded by: hsa:8706
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: B3GALNT1
constant: false
initial concentration: NaN
is: B3KTQ4
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110024#_c3fe6fd6_f4c7_4e12_b0d6_c0b831b4da51
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3283
is: SBO:0000252
name: HSD3B1
is: P14060
has only substance units: false
constant: false

metaM cs b deg1 l
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
type: Species
initial amount: NaN
is: HMDB01354
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:57455
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 1
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110024#_5c6eae86_8d4b_4251_9769_27bdea9c5d11
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
name: COX5B
type: Species
boundary condition: true
is encoded by: hsa:1329
is: Q53YB7
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_40c2a3e7_559c_48fa_85a3_33992450e60d
name: _AI222095_1_m
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AI222095
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_1c181eea_f052_4326_b9c1_cd55cf95676c
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:AI191472
type: Species
initial concentration: NaN
name: _AI191472_1_c
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110024#_d0d30d15_673d_479e_8d84_8f7fc9819b09
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: SPTLC2
is: O15270
is encoded by: hsa:9517
constant: false

metaM glc D r
initial concentration: 1.0
initial amount: NaN
name: D-glucose
is: HMDB00122
constant: false
boundary condition: false
is: CHEBI:4167
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040

metaM vacccoa m
name: vaccenyl coenzyme A
initial concentration: 1.0
type: Species
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h9-10,26-28,32-34,38,49-50H,4-8,11-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b10-9+/t28-,32-,33?,34+,38-/m1/s1
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB06521
is: http://identifiers.org/pubchem.compound/9543677
has only substance units: false

metaR RE3346C
reversible: true
reactant: MODEL1310110024#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (223.1) or (218.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
name: RE3346
product: MODEL1310110024#
type: Reaction
modifier: MODEL1310110024#
is described by: ECO:0000000
kinetic law: MODEL1310110024#
fast: false

metaR FAOXC101C102x
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_246c47a5_ac3c_4b41_a168_a44fb6622e2a
boundary condition: true
initial concentration: NaN
has part: B4E3E9
constant: false
is: SBO:0000297
type: Species
has only substance units: false
initial amount: NaN
name: DLD:DLST:OGDH:PDHX
is encoded by: hsa:4967

http://identifiers.org/biomodels.db/MODEL1310110024#_83879c06_5a1c_4ab9_a9c9_7f11ebf8985e
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AI090874
name: _AI090874_1_c
constant: false
initial amount: NaN
is: SBO:0000252
type: Species

metaR FAOXC11C9m
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C11-->C9)m
type: Reaction

metaR RE0453C
reversible: true
type: Reaction
kinetic law: MODEL1310110024#
fast: false
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
is described by: ECO:0000000
name: RE0453
is: SBO:0000176
reactant: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_ad5b07e8_9c49_49c2_8234_1593b8d3cad6
boundary condition: true
name: BCAT1
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:586
is: P54687
type: Species

metaR r2103
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110024#
is: SBO:0000185
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
kinetic law: MODEL1310110024#
reversible: true
modifier: MODEL1310110024#
product: MODEL1310110024#

metaR r2030
product: MODEL1310110024#
modifier: MODEL1310110024#
fast: false
reactant: MODEL1310110024#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
kinetic law: MODEL1310110024#
type: Reaction

metaR FADH2ETC
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reversible: false
fast: false
type: Reaction
reactant: MODEL1310110024#
is: SBO:0000176
name: Complex II reaction for respiratory chain

metaR CMPSASn
is described by: ECO:0000304
name: CMP sialic acid synthase, nuclear
product: MODEL1310110024#
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
is: SBO:0000176
reactant: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.7.43
type: Reaction
reversible: false

metaR GHMT2r
reactant: MODEL1310110024#
fast: false
is: SBO:0000176
reversible: true
name: glycine hydroxymethyltransferase, reversible
product: MODEL1310110024#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (6470.1) or (6470.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.1.2.1

metaM hxan c
constant: false
initial concentration: 1.0
is: CHEBI:17368
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
is: SBO:0000247
is: HMDB00157
is: C00262
boundary condition: false
name: Hypoxanthine

metaR PUNP7
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.4.2.1
fast: false
name: purine-nucleoside phosphorylase (Xanthosine)
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
is: SBO:0000176
reversible: true
modifier: MODEL1310110024#
type: Reaction
is described by: ECO:0000269

metaR r2102
reactant: MODEL1310110024#
is: SBO:0000185
modifier: MODEL1310110024#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
kinetic law: MODEL1310110024#
is described by: ECO:0000000
product: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true

metaR IDOURte
reversible: true
type: Reaction
name: L-iduronate transport, extracellular
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
fast: false
is: SBO:0000185
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_49e15f4c_6453_43ce_a04a_04fe66f7054f
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:51227
name: PIGP

metaM h c
notes: FORMULA: H CHARGE: 1 INCHI: "
constant: false
is: CHEBI:24636
is: SBO:0000247
name: proton
type: Species
is: C00080
is: http://identifiers.org/pubchem.compound/3380
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110024#_0f05eaf0_f079_4d42_9e72_df854f5817c6
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:9551
is: P56134
name: ATP5J2
type: Species
has only substance units: false
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_51144502_cf9f_475b_8705_66be6bb51df3
is: P49753
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:10965
type: Species
name: ACOT2
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaM tdchola c
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
name: taurochenodeoxycholate
initial amount: NaN
type: Species
boundary condition: false
constant: false
is: HMDB00951
has only substance units: false
is: SBO:0000247
is: CHEBI:9407
initial concentration: 1.0

metaR DHDPBMTm
fast: false
reversible: false
product: MODEL1310110024#
is described by: ECO:0000269
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (51805.1) SUBSYSTEM: Ubiquinone synthesis EC Number: 2.1.1.114 Confidence Level: 4 AUTHORS: PMID:10777520,PMID:1965190,PMID:7380842 NOTES:Used to make Ubiquinone-10 EC 2.1.1.114 IT
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.1.1.114
type: Reaction
name: dihydroxydecaprenylbenzoate methyltransferase
is: SBO:0000176
kinetic law: MODEL1310110024#

metaR C3STDH1Pr
modifier: MODEL1310110024#
reversible: false
reactant: MODEL1310110024#
type: Reaction
name: C-3 sterol dehydrogenase (4-methylzymosterol)
fast: false
is: SBO:0000176
product: MODEL1310110024#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10710235,PMID:14506130 NOTES:NCD ER version NJ
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.1.1.170

metaR BTNDe
type: Reaction
name: biotinidase (biotin), extracellular
fast: false
product: MODEL1310110024#
kinetic law: MODEL1310110024#
is described by: ECO:0000269
modifier: MODEL1310110024#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.5.1.12
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7509806,PMID:8001986 NOTES:Also acts on biotin esters IT
reactant: MODEL1310110024#

metaR EX HC02207 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-c2 exchange
type: Reaction

metaR r2105
is described by: ECO:0000000
product: MODEL1310110024#
modifier: MODEL1310110024#
reactant: MODEL1310110024#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
kinetic law: MODEL1310110024#

metaR r2032
is: SBO:0000185
product: MODEL1310110024#
modifier: MODEL1310110024#
reversible: false
kinetic law: MODEL1310110024#
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r1150
is: SBO:0000185
is described by: ECO:0000000
name: Facilitated diffusion
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
product: MODEL1310110024#
type: Reaction
reversible: false
modifier: MODEL1310110024#
fast: false
kinetic law: MODEL1310110024#

metaR GLCNACT L
kinetic law: MODEL1310110024#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.141 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
type: Reaction
name: UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase (liver)
product: MODEL1310110024#
reversible: false
reactant: MODEL1310110024#
fast: false

metaR THYMt
is: SBO:0000185
type: Reaction
name: thymine reversible transport via facilated diffusion
reactant: MODEL1310110024#
modifier: MODEL1310110024#
is described by: ECO:0000269
kinetic law: MODEL1310110024#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
product: MODEL1310110024#

metaR r0523
modifier: MODEL1310110024#
fast: false
reversible: false
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
is: SBO:0000176
product: MODEL1310110024#
is described by: ECO:0000000
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.17.4.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_060ae4b8_4d21_4b78_b0eb_ea4eef1df20c
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: AK2
boundary condition: true
is encoded by: hsa:204
constant: false
has only substance units: false
type: Species

metaR r0410
is: SBO:0000176
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
reversible: true
is described by: ECO:0000000
product: MODEL1310110024#
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_00a93ec8_906f_46a0_a75c_dd6e85f76750
name: SDHA
initial amount: NaN
boundary condition: true
is encoded by: hsa:6389
is: P31040
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaM lgnc c
boundary condition: false
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
is: CHEBI:31014
constant: false
name: lignocerate
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB02003
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_ff6716e2_0be8_460e_b978_9e400b37edb9
is: Q16795
is encoded by: hsa:4704
name: NDUFA9
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN

metaM h e
has only substance units: false
initial concentration: 1.0
is: CHEBI:24636
notes: FORMULA: H CHARGE: 1 INCHI: "
is: SBO:0000247
name: proton
type: Species
is: C00080
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3380
constant: false
boundary condition: false

metaR r2104
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is described by: ECO:0000000
modifier: MODEL1310110024#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110024#
type: Reaction
product: MODEL1310110024#
reactant: MODEL1310110024#
is: SBO:0000185

metaR GLCNACPT L
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
reversible: false
notes: GENE_ASSOCIATION: (1798.1) or (1798.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.7.8.15 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110024#
is: SBO:0000176
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.7.8.15
fast: false
name: UDP-GlcNAc:dolichol-phosphate GlcNAc phosphotransferase (liver)
is described by: ECO:0000000
type: Reaction

metaM lgnc e
name: lignocerate
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
boundary condition: false
is: SBO:0000247
is: CHEBI:31014
is: HMDB02003
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_e9f54f6a_d1ac_41d5_b969_31b34e8904d6
is encoded by: hsa:111
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
has only substance units: false
name: ADCY5
is: O95622
boundary condition: true

metaR RE1845C
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 4 h[c] from compEHMN reaction as they were not necessary
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110024#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.65
name: RE1845
modifier: MODEL1310110024#
reactant: MODEL1310110024#
reversible: true

metaM itp n
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
name: ITP(3-)
is: CHEBI:57614
is: HMDB00189
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species

metaM ksii core4 g
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB01644
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
is: CHEBI:17140
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
name: keratan sulfate II (core 4-linked)

metaM 5dhf e
name: pentaglutamyl folate (DHF)
boundary condition: false
initial amount: NaN
is: HMDB06487
constant: false
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaR r0522
fast: false
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110024#
type: Reaction
product: MODEL1310110024#
modifier: MODEL1310110024#
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
is: SBO:0000176

metaM bamppald c
notes: FORMULA: C3H8NO CHARGE: 1 INCHI: InChI=1/C3H7NO/c4-2-1-3-5/h3H,1-2,4H2 EHMN_ABBREVIATION: C05665
name: beta-Aminopropion aldehyde
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
is: C05665
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/7975
is: HMDB01106

http://identifiers.org/biomodels.db/MODEL1310110024#_d3540a34_883a_4906_b6a3_0c5333efc234
is encoded by: hsa:23169
constant: false
is: SBO:0000252
has only substance units: false
name: SLC35D1
is: Q9NTN3
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species

metaR r1156
type: Reaction
is: SBO:0000176
fast: false
reversible: true
product: MODEL1310110024#
is described by: ECO:0000000
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48

metaR EX 2hb LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Hydroxybutyrate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_82b75b32_8b1e_4ff6_aebf_f8a8ab3a91dd
is encoded by: hsa:9334
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: B4GALT5
boundary condition: true
constant: false
type: Species
is: O43286
initial concentration: NaN

metaR 34HPLFM
kinetic law: MODEL1310110024#
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
reversible: false
reactant: MODEL1310110024#
product: MODEL1310110024#
is described by: ECO:0000000
name: 3-(4-hydroxyphenyl-)lactate formation

metaR NADH2 u10m
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.6.99.3
fast: false
reversible: false
type: Reaction
modifier: MODEL1310110024#
is: SBO:0000185
notes: GENE_ASSOCIATION: (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (4694.1) and (374291.1) and (4728.1) and (4717.1) and (4731.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (4722.1) and (7991.1) and (4541.1) and (4539.1) and (4712.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4706.1) and (4535.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (4712.2) and (4717.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (7991.1) and (4722.1) and (4541.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (126328.1) and (4711.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4729.1) and (4540.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (7991.2) and (4717.1) and (4705.1) and (4725.1) and (4537.1) and (4716.1) and (4722.1) and (4541.1) and (4712.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (374291.1) and (4694.1) and (4728.1) and (4712.2) and (4717.1) and (4731.1) and (…
reactant: MODEL1310110024#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.6.5.3
name: NADH dehydrogenase, mitochondrial
kinetic law: MODEL1310110024#

metaR AG13T4g
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
reversible: false
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (10331.1) or (374907.1) or (146712.1) or (374907.2) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110024#
is described by: ECO:0000000
reactant: MODEL1310110024#
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus

metaR r2107
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
fast: false

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

metaR FUMtm
name: fumarate transport, mitochondrial
product: MODEL1310110024#
fast: false
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110024#
is: SBO:0000185
modifier: MODEL1310110024#
reversible: true

metaM gd3 hs g
notes: FORMULA: C52H88N3O28FULLRCO CHARGE: -2
has only substance units: false
name: GD3
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:28424
constant: false
is: SBO:0000247

metaR DESAT18 4
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
product: MODEL1310110024#
is described by: ECO:0000000
name: stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.14.19.1
is: SBO:0000176
reversible: false
fast: false
modifier: MODEL1310110024#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_e89986cc_8d96_4eed_9c9e_4df3f4e0c1c7
constant: false
type: Species
is encoded by: hsa:5831
has only substance units: false
boundary condition: true
name: PYCR1
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: A6NFM2

metaR HS3ly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.10.1.1
is: SBO:0000176
modifier: MODEL1310110024#
name: heparan-N-sulfatase, lysosomal
reactant: MODEL1310110024#
type: Reaction
product: MODEL1310110024#
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110024#_0bc18ff6_9653_4008_a221_b1f89d9e09d8
constant: false
is: SBO:0000252
has only substance units: false
is: Q14117
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1807
name: DPYS

http://identifiers.org/biomodels.db/MODEL1310110024#_4d2b1e71_1cfb_4892_b67f_8b3ce33483e1
name: ALDH3A2
constant: false
has only substance units: false
is: P51648
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:224
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_a0bba542_a76c_42c8_a8f8_76998857a1da
name: DEGS1
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:8560

metaR ARACHDCOAtx
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
name: fatty acid intracellular transport
fast: false
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
product: MODEL1310110024#

metaM h g
constant: false
is: CHEBI:24636
initial concentration: 1.0
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
name: proton
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species

metaR FAOXC101C102m
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)m
type: Reaction

metaR GLYSNAT5tc
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_085eaf65_f537_4045_8ec2_0e6778fb153c
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
name: ATP5G2
has only substance units: false
is encoded by: hsa:517

metaR ADAe
kinetic law: MODEL1310110024#
is: SBO:0000176
name: Adenosine deaminase, extracellular
product: MODEL1310110024#
type: Reaction
modifier: MODEL1310110024#
reactant: MODEL1310110024#
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.4
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT

metaR r2106
reversible: true
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
fast: false
kinetic law: MODEL1310110024#
product: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_a417be4d_1fca_44ed_9446_88f562995807
type: Species
is: Q8WYR1
boundary condition: true
is encoded by: hsa:23533
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: PIK3R5
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_a5274437_a5b2_433a_ba92_84b92d1790a3
is encoded by: hsa:8050
name: DLD:DLST:OGDH:PDHX
is encoded by: hsa:1738
initial concentration: NaN
has part: O00330
has part: P36957
initial amount: NaN
has part: P09622
type: Species
boundary condition: true
is: SBO:0000297
constant: false
is encoded by: hsa:1743
has only substance units: false
is encoded by: hsa:4967
has part: Q02218

http://identifiers.org/biomodels.db/MODEL1310110024#_f7f2366d_83fa_4159_ac7f_46f0778f0e80
initial amount: NaN
initial concentration: NaN
type: Species
is: P04745
name: AMY1B
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:277

metaM gsn c
constant: false
is: CHEBI:16750
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: Guanosine
type: Species
is: C00387
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
boundary condition: false
is: SBO:0000247
is: HMDB00133

http://identifiers.org/biomodels.db/MODEL1310110024#_f032fabc_bcb4_4193_a45a_9a08f24775db
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: Q9UJS0
is encoded by: hsa:10165
boundary condition: true
constant: false
name: SLC25A13
is: SBO:0000252
type: Species

metaM ksii core4 e
constant: false
name: keratan sulfate II (core 4-linked)
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB00211
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
is: CHEBI:17268

http://identifiers.org/biomodels.db/MODEL1310110024#_e24eab22_1085_4043_a880_97b488b92247
has only substance units: false
is: Q8NEM3
type: Species
initial amount: NaN
is encoded by: hsa:9194
initial concentration: NaN
name: SLC16A7
boundary condition: true
constant: false
is: SBO:0000252

metaR r1154
reversible: true
kinetic law: MODEL1310110024#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110024#
name: EC:1.2.7.2
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 1.2.7.2 Confidence Level: 0 AUTHORS: PMID:2649080,PMID:283398,PMID:3718468,PMID:9381974 NOTES:
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110024#_85577005_45c9_49bb_9c83_12f42e21c71c
is: P11908
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:5634
is: SBO:0000252
name: PRPS2
type: Species
boundary condition: true

metaR r0527
product: MODEL1310110024#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110024#
fast: false
name: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
is described by: ECO:0000000
reactant: MODEL1310110024#
type: Reaction

metaM hxan e
has only substance units: false
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
is: HMDB00157
is: SBO:0000247
initial amount: NaN
is: CHEBI:17368
name: hypoxanthine
constant: false
type: Species
initial concentration: 1.0
boundary condition: false

metaR TPI
reversible: true
fast: false
name: triose-phosphate isomerase
type: Reaction
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/5.3.1.1
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
product: MODEL1310110024#
is: SBO:0000176
modifier: MODEL1310110024#

metaR r2109
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
product: MODEL1310110024#
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
reactant: MODEL1310110024#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR MEVK1x
product: MODEL1310110024#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4598.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.7.1.36 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version NJ
fast: false
name: mevalonate kinase (atp)
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
modifier: MODEL1310110024#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.7.1.36
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110024#_af6e4e3a_978a_4c1b_a41d_84729088b711
name: HPGDS
initial concentration: NaN
is: O60760
is: SBO:0000252
constant: false
is encoded by: hsa:27306
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species

metaM 2decdicoa m
boundary condition: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966
name: 2,7-decadienoylcoa
type: Species
initial concentration: 1.0
constant: false

metaM ipdp c
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:128769
is: C00129
is: SBO:0000247
boundary condition: false
name: Isopentenyl diphosphate
type: Species
has only substance units: false
notes: FORMULA: C5H9O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
is: HMDB01347

metaR r1155
reversible: false
fast: false
name: TCDB:2.A.1.13.5 TCDB:2.A.1.13.1
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12107270,PMID:12739169,PMID:12829793,PMID:17245649,PMID:18375207,PMID:8476015,PMID:8557697,PMID:9786900 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110024#
is: SBO:0000185
type: Reaction
product: MODEL1310110024#

metaR ASNt4
name: L-asparagine transport in via sodium symport
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:SAB
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110024#
type: Reaction
fast: false
reversible: false
reactant: MODEL1310110024#

metaM CE1943 e
has only substance units: false
notes: FORMULA: C7H14NO2 CHARGE: 1 INCHI: InChI=1/C7H13NO2/c9-6-2-1-4-8-5-3-7-10/h6-8H,1-5H2/p+1 EHMN_ABBREVIATION: CE1943
is: SBO:0000247
is: HMDB02329
boundary condition: false
name: spermidine dialdehyde
is: CHEBI:30623
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0

metaM dag hs r
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:18035
constant: false
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
boundary condition: false
name: diglyceride
initial amount: NaN
has only substance units: false

metaM ddcacoa m
initial concentration: 1.0
boundary condition: false
is: CHEBI:57375
has only substance units: false
type: Species
is: C01832
is: HMDB03571
constant: false
name: Dodecanoyl-CoA (n-C12:0CoA)
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
initial amount: NaN
is: SBO:0000247

metaM glx m
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
initial amount: NaN
is: SBO:0000247
constant: false
name: glyoxylate
has only substance units: false
is: HMDB00119
is: CHEBI:36655
type: Species

metaR r2108
kinetic law: MODEL1310110024#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110024#
reversible: true
is: SBO:0000185
modifier: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110024#

metaM alpam m
initial amount: NaN
is: HMDB06239
notes: FORMULA: C9H21N2OS2 CHARGE: 1 INCHI: InChI=1/C9H20N2OS2/c10-7-14-6-5-8(13)3-1-2-4-9(11)12/h8,13H,1-7,10H2,(H2,11,12)
constant: false
name: S-aminomethyldihydrolipoamide
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false

metaM tmndnccoa c
constant: false
name: timnodonyl coenzyme A
type: Species
is: HMDB06514
is: SBO:0000247
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaM dcsptn1coa c
is: http://identifiers.org/pubchem.compound/47205483
initial concentration: 1.0
initial amount: NaN
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
is: SBO:0000247
boundary condition: false
is: C16173
constant: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
type: Species
is: HMDB06513
has only substance units: false

metaM gsn e
is: SBO:0000247
is: HMDB00133
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:16750
is: C00387
name: Guanosine
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
has only substance units: false
type: Species

metaR FUMSO3tm
product: MODEL1310110024#
name: Fumarate:sulfite antiport, mitochondrial
reactant: MODEL1310110024#
reversible: true
type: Reaction
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is: SBO:0000185
modifier: MODEL1310110024#
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110024#_ff178c2c_cb93_4c89_bde5_90c81459d8a3
initial amount: NaN
type: Species
boundary condition: true
is: E5KNH5
has only substance units: false
is encoded by: hsa:4723
is: SBO:0000252
name: NDUFV1
initial concentration: NaN
constant: false

metaR ELAIDCPT1
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110024#
type: Reaction
fast: false
modifier: MODEL1310110024#
reactant: MODEL1310110024#
is: SBO:0000176
kinetic law: MODEL1310110024#
is described by: ECO:0000269
name: carnitine O-palmitoyltransferase

metaR r2327
is: SBO:0000185
fast: false
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110024#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
reversible: true
kinetic law: MODEL1310110024#

metaR TDCHOLAte
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
product: MODEL1310110024#
name: bile acid intracellular transport
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#

metaR DESAT18 8
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.99.25 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
fast: false
name: fatty acyl-CoA desaturase (n-C18:1CoA -> n-C18:2CoA)
reactant: MODEL1310110024#
product: MODEL1310110024#
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110024#
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_da4bd682_37e8_413a_b3e9_24a37eadd08f
name: VNN3:VNN2:VNN1
is encoded by: hsa:55350
is encoded by: hsa:8875
has part: A8K7W0
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000297
initial concentration: NaN
is encoded by: hsa:8876
constant: false
has part: O95497
initial amount: NaN

metaM 5tedtricoa m
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
name: 5,8,11-tetradecatrienoylcoa
type: Species
notes: FORMULA: C35H52N7O17P3S CHARGE: -4
is: HMDB02288

http://identifiers.org/biomodels.db/MODEL1310110024#_350cf350_4f71_42be_814a_4ca42c04bf61
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:1629
boundary condition: true
is: P11182
has only substance units: false
name: DBT
type: Species

metaM vacccoa c
is: http://identifiers.org/pubchem.compound/9543677
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h9-10,26-28,32-34,38,49-50H,4-8,11-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b10-9+/t28-,32-,33?,34+,38-/m1/s1
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: vaccenyl coenzyme A
is: HMDB06521
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_cd593197_80f4_4c84_95e4_963999913260
is encoded by: hsa:AI539321
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
constant: false
name: _AI539321_1_c

metaR URATEt
name: urate export from cytosol
is: SBO:0000185
fast: false
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110024#
product: MODEL1310110024#

metaM icit x
is: CHEBI:16087
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
is: HMDB00193
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
type: Species
name: isocitrate(3-)
initial concentration: 1.0
boundary condition: false

metaR ACGAMK
notes: GENE_ASSOCIATION: (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.59 Confidence Level: 4 AUTHORS: PMID:10824116 NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110024#
fast: false
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.59
reactant: MODEL1310110024#
type: Reaction
product: MODEL1310110024#
name: N-acetylglucosamine kinase
modifier: MODEL1310110024#

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

metaR H2O2tp
is: SBO:0000185
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
type: Reaction
name: hydrogen peroxide peroxisomal transport via diffusion
fast: false

metaM man g
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:16024
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
name: D-mannose
is: HMDB00169
has only substance units: false
constant: false

metaR FUCtly
product: MODEL1310110024#
is described by: ECO:0000000
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110024#
fast: false
name: L-fucose efflux from lysosome
type: Reaction
reversible: false

metaR NTP3e
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.15 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
is version of: http://identifiers.org/ec-code/3.6.1.6
kinetic law: MODEL1310110024#
product: MODEL1310110024#
name: nucleoside-triphosphatase (GTP)
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110024#
modifier: MODEL1310110024#
reversible: false
fast: false
type: Reaction

metaM adrncrn c
name: Adrenyl carnitine
has only substance units: false
is: C00318
notes: FORMULA: C29H49NO4 CHARGE: 0
is: SBO:0000247
constant: false
is: HMDB00062
is: CHEBI:16347
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species

metaR r2326
reversible: true
reactant: MODEL1310110024#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110024#
is: SBO:0000185
fast: false
product: MODEL1310110024#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR THMMPtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12014993,PMID:9755848 NOTES:IT
reactant: MODEL1310110024#
is: SBO:0000185
type: Reaction
product: MODEL1310110024#
reversible: true
kinetic law: MODEL1310110024#
name: Thiamine monophosphate transport, mitochondrial
is described by: ECO:0000000
fast: false

metaR BTNDm
is version of: http://identifiers.org/ec-code/3.5.1.12
fast: false
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:Also acts on biotin esters IT
reactant: MODEL1310110024#
reversible: false
is: SBO:0000176
name: biotinidase (biotin), mitochondrial
kinetic law: MODEL1310110024#
is described by: ECO:0000269
modifier: MODEL1310110024#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_ef7e1e99_8ad4_48f1_810d_2149f5cedcb0
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
name: ECHS1
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1892
type: Species
is: P30084

http://identifiers.org/biomodels.db/MODEL1310110024#_952625c8_f8c6_4e24_896f_21141b4f65b8
is encoded by: hsa:9374
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true
name: PPT2
is: Q9UMR5

http://identifiers.org/biomodels.db/MODEL1310110024#_37d17213_e742_45a7_ae1e_cd5bd4ef2f18
boundary condition: true
is: P48736
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5294
type: Species
initial amount: NaN
name: PIK3CG

metaR EX 3mop LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxopentanoate
type: Reaction

metaM hpdca e
type: Species
is: HMDB02259
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C17H33O2 CHARGE: -1 INCHI: InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)/p-1
is: CHEBI:32366
name: margarate
constant: false
is: SBO:0000247
boundary condition: false

metaM itp c
initial amount: NaN
type: Species
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
is: SBO:0000247
is: CHEBI:57614
boundary condition: false
is: HMDB00189
initial concentration: 1.0
constant: false
has only substance units: false
name: ITP(3-)

metaR OAGD3te
reversible: true
product: MODEL1310110024#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
name: oagd3 hs transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_ef18cab0_d256_48b8_b778_df74cf13eeee
is: O14561
constant: false
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: NDUFAB1
initial amount: NaN
is encoded by: hsa:4706

metaR FAOXC163C164Gm
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)gm
type: Reaction

metaR DCTPtn
type: Reaction
is: SBO:0000185
reactant: MODEL1310110024#
fast: false
name: dCTP diffusion in nucleus
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110024#
product: MODEL1310110024#
is described by: ECO:0000000

metaR r1088
type: Reaction
reversible: true
name: Active transport
reactant: MODEL1310110024#
product: MODEL1310110024#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110024#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

metaM orot5p c
is: SBO:0000247
is: CHEBI:57538
constant: false
type: Species
initial amount: NaN
name: Orotidine 5'-phosphate
notes: FORMULA: C10H10N2O11P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00669 EHMN_ABBREVIATION: C01103
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: C01103
is: HMDB00218

metaR LCADi
modifier: MODEL1310110024#
is: SBO:0000176
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.2.1.36
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.2.1.3
name: lactaldehyde dehydrogenase
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
is described by: ECO:0000304
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110024#_2bc26552_1c40_470a_bb4c_f7cbc409b8ed
has only substance units: false
initial amount: NaN
is: Q9Y672
is encoded by: hsa:29929
type: Species
is: SBO:0000252
name: ALG6
constant: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110024#_fe5437fb_bb39_4fd0_9fce_d1da519c0e87
is encoded by: hsa:790
type: Species
initial concentration: NaN
is: SBO:0000252
is: P27708
initial amount: NaN
name: CAD
has only substance units: false
boundary condition: true
constant: false

metaM dcsptn1coa m
constant: false
type: Species
initial concentration: 1.0
is: HMDB06513
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
is: C16173
is: http://identifiers.org/pubchem.compound/47205483
has only substance units: false
is: SBO:0000247
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
boundary condition: false
initial amount: NaN

metaR TMNDNCCPT1
is: SBO:0000176
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
name: carnitine O-palmitoyltransferase
fast: false
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110024#
product: MODEL1310110024#

metaR LACLt
reversible: false
fast: false
type: Reaction
kinetic law: MODEL1310110024#
name: Lactate transport
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMCID: PMC1820816. NOTES:for regeneration of nad in peroxisomes, for providing nad to the beta oxidation
reactant: MODEL1310110024#
is: SBO:0000185
product: MODEL1310110024#

metaR r2539
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110024#
reversible: true
reactant: MODEL1310110024#
type: Reaction
name: Postulated transport reaction
fast: false
is: SBO:0000185
product: MODEL1310110024#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110024#_f289b574_432e_4c29_9dcb_15a5daedbfeb
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is: Q96I99
name: SUCLG2
is encoded by: hsa:8801

metaM m2emgacpail hs r
is: SBO:0000247
notes: FORMULA: C51H94N2O32P2FULLRCO2FULLR2CO2 CHARGE: 0
type: Species
name: (dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (H6)
has only substance units: false
is: http://identifiers.org/pubchem.compound/3380
is: C00080
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:24636
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110024#_756d3b71_cb96_4010_a14a_92a3251a6279
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:223
name: ALDH9A1
initial concentration: NaN
is: P49189

metaR EICOSTETt
name: fatty acid transport via diffusion
fast: false
is described by: ECO:0000000
reactant: MODEL1310110024#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
product: MODEL1310110024#
type: Reaction
kinetic law: MODEL1310110024#

metaR ADPCOAPTE
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of adipoyl coA for release into cytosol
type: Reaction

metaR OCD11CRNCPT2
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaR EX ak2lgchol hs LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-lysoglycerol 3-phosphocholine exchange
type: Reaction

metaR r2325
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
product: MODEL1310110024#
kinetic law: MODEL1310110024#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
fast: false
is described by: ECO:0000000

metaR FAOXC163C164x
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)x
type: Reaction

metaM h l
notes: FORMULA: H CHARGE: 1 INCHI: "
is: CHEBI:24636
type: Species
initial amount: NaN
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3380
has only substance units: false
boundary condition: false
constant: false
name: proton
is: C00080
initial concentration: 1.0

metaR S6TASE10ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
is described by: ECO:0000000
product: MODEL1310110024#
name: galactose-6-sulfate sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_d6eac51d_d30e_49dc_b269_0d5f6733806a
constant: false
is encoded by: hsa:123041
name: SLC24A4
is: Q8NFF2
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true

metaR r2538
is: SBO:0000185
product: MODEL1310110024#
reactant: MODEL1310110024#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Utilized transport
type: Reaction
fast: false
kinetic law: MODEL1310110024#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110024#_779e4711_97d9_422e_bc79_0509c0f613b2
is encoded by: hsa:6649
type: Species
boundary condition: true
name: SOD3
has only substance units: false
constant: false
is: P08294
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaM oagd3 hs g
boundary condition: false
name: 9-O-Acetylated GD3
type: Species
initial concentration: 1.0
is: HMDB00286
is: CHEBI:58367
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
is: C00029

metaM hpdca c
name: margarate
initial concentration: 1.0
boundary condition: false
is: HMDB02259
notes: FORMULA: C17H33O2 CHARGE: -1 INCHI: InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)/p-1
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:32366

metaM itp e
has only substance units: false
name: ITP(3-)
is: SBO:0000247
type: Species
is: CHEBI:57614
boundary condition: false
is: HMDB00189
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
constant: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_74f2ace0_11b3_4dba_a359_dce69630056b
is: P23786
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1376
name: CPT2
boundary condition: true
constant: false

metaR DRIBt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
type: Reaction
reactant: MODEL1310110024#
is described by: ECO:0000000
kinetic law: MODEL1310110024#
product: MODEL1310110024#
fast: false
reversible: true
name: deoxyribose transport via diffusion
is: SBO:0000185

metaR NAt3 1
type: Reaction
is: SBO:0000185
name: sodium proton antiporter (H:NA is 1:1)
fast: false
notes: GENE_ASSOCIATION: (389015.1) or (6548.1) or (6550.1) or (6549.1) or (6553.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:7759094,PMID:8199403,PMID:8595899,PMID:9933641 NOTES:JLR
product: MODEL1310110024#
reactant: MODEL1310110024#
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
is described by: ECO:0000269
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110024#_fc6c6657_a919_415c_910c_471f05915430
constant: false
is encoded by: hsa:3155
has only substance units: false
type: Species
is: SBO:0000252
is: Q6IBC0
name: HMGCL
boundary condition: true
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_d313fa17_b702_4765_857a_be2acd48ebca
name: ALG8
is encoded by: hsa:79053
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_313301fe_5249_4cf6_9456_b1d86efa67ef
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5293
is: A7E2E0
is: SBO:0000252
constant: false
name: PIK3CD
type: Species

metaR r2324
kinetic law: MODEL1310110024#
is: SBO:0000185
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110024#

metaM h m
is: http://identifiers.org/pubchem.compound/3380
is: CHEBI:24636
boundary condition: false
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
type: Species
initial amount: NaN
is: SBO:0000247
is: C00080
constant: false
has only substance units: false
initial concentration: 1.0
name: proton

metaM ivcoa m
is: CHEBI:57345
type: Species
has only substance units: false
boundary condition: false
is: HMDB01113
initial concentration: 1.0
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939
constant: false
is: SBO:0000247
name: Isovaleryl-CoA
initial amount: NaN

metaR AMANK
name: N-acetyl-D-mannosamine kinase
is version of: http://identifiers.org/ec-code/2.7.1.59
modifier: MODEL1310110024#
reversible: false
fast: false
product: MODEL1310110024#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.1.3.14
reactant: MODEL1310110024#
is described by: ECO:0000269
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (10020.1) or (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.60 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835,PMID:11308027 NOTES:JLR - Kegg R02705
type: Reaction

metaM dmhptcrn c
constant: false
has only substance units: false
is: SBO:0000247
type: Species
name: 2,6 dimethylheptanoyl carnitine
initial concentration: 1.0
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
initial amount: NaN
boundary condition: false
is: HMDB06320

http://identifiers.org/biomodels.db/MODEL1310110024#_63cef6bf_e05e_4833_8415_70e098103384
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is encoded by: hsa:3295
name: ACAA1:HSD17B4:ACOX1
has part: E9PB82
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110024#_064599c4_80bd_49c0_8596_d9c3cc816a79
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:23533
is: SBO:0000297
has part: Q8WYR1
constant: false
name: PIK3R5:PIK3CG

http://identifiers.org/biomodels.db/MODEL1310110024#_b1070b2a_9a64_4858_9fa4_a6c378c8a32e
type: Species
is: Q16647
initial concentration: NaN
name: PTGIS
has only substance units: false
is encoded by: hsa:5740
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false

metaR RE1533M
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
type: Reaction
name: RE1533
product: MODEL1310110024#
reactant: MODEL1310110024#

metaR NACHEX26ly
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110024#
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
reversible: false
reactant: MODEL1310110024#
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110024#_ea6bdcb5_928f_4217_9bef_f2de92b10944
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: TALDO1
is encoded by: hsa:6888
is: P37837
boundary condition: true

metaM cl c
name: Chloride
initial amount: NaN
boundary condition: false
is: C00115
is: HMDB00492
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: Cl CHARGE: -1
type: Species
is: CHEBI:3966

metaR r2537
name: Utilized transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is: SBO:0000185
is described by: ECO:0000000

metaM man c
is: HMDB00169
has only substance units: false
is: CHEBI:16024
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
name: D-Mannose
boundary condition: false
initial concentration: 1.0
is: C00159
constant: false

metaM h n
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
name: proton
is: CHEBI:24636
type: Species

metaR r2323
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110024#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
is: SBO:0000185
fast: false
is described by: ECO:0000000
product: MODEL1310110024#
reactant: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_c459a8d0_1b9f_4b9e_a829_7084c3acc6bb
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
name: PIGA
is encoded by: hsa:5277
boundary condition: true

metaR TRIODTHYt2
product: MODEL1310110024#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
reversible: true
is described by: ECO:0000269
name: T3 transport via facilitated diffusion
fast: false
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_a5d8c251_3d39_4659_b162_be2fb9231fff
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:55512
boundary condition: true
name: SMPD3
is: SBO:0000252
is: A8K0T6
has only substance units: false
type: Species
constant: false

metaM oagd3 hs e
initial amount: NaN
is: HMDB02168
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:18421
name: 9-O-Acetylated GD3
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110024#_02bf285a_e873_4ffc_85f3_7e64b1679800
boundary condition: true
is: P30838
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:218
initial amount: NaN
constant: false
name: ALDH3A1
initial concentration: NaN

metaR TMNDNCCPT2
modifier: MODEL1310110024#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine transferase
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
fast: false
product: MODEL1310110024#

metaM ksi pre11 g
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
name: keratan sulfate I biosynthesis, precursor 11
is: CHEBI:28067
constant: false
notes: FORMULA: C129H208N9O101S3X CHARGE: -4

metaR SCPx
is described by: ECO:0000269
reactant: MODEL1310110024#
name: peroxisomal thiolase 2
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways NJ
is version of: http://identifiers.org/ec-code/2.3.1.176
reversible: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false
product: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_e96583c0_576d_4798_b7e7_9edb15356637
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
name: ST3GAL5
initial amount: NaN
constant: false
is: Q9UNP4
is encoded by: hsa:8869

http://identifiers.org/biomodels.db/MODEL1310110024#_f904b739_e631_4daf_b803_6e2328d3167b
has only substance units: false
initial amount: NaN
is: E7EPT3
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:501
boundary condition: true
name: ALDH7A1

metaR r2322
kinetic law: MODEL1310110024#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110024#
reactant: MODEL1310110024#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000

metaR C161CRN2t
name: C161 transport into the mitochondria
reversible: false
product: MODEL1310110024#
kinetic law: MODEL1310110024#
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110024#
reactant: MODEL1310110024#

metaR SIAASE2ly
is described by: ECO:0000000
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
is: SBO:0000176
product: MODEL1310110024#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
name: sialidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110024#

metaM ksii core4 deg3 l
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C66H107N6O51S2X CHARGE: -2
constant: false
name: keratan sulfate II (core 4-linked), degradation product 3
is: HMDB00143
type: Species
is: CHEBI:12936

http://identifiers.org/biomodels.db/MODEL1310110024#_69a69e92_f1a8_4115_944f_2077606adadb
initial concentration: NaN
constant: false
type: Species
name: ALDH1B1
is: SBO:0000252
boundary condition: true
is encoded by: hsa:219
initial amount: NaN
has only substance units: false
is: P30837

http://identifiers.org/biomodels.db/MODEL1310110024#_38ba6d41_1610_4b25_b450_fa31315c59cb
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:5091
type: Species
initial concentration: NaN
name: PC

metaR ACGPID
product: MODEL1310110024#
reactant: MODEL1310110024#
is: SBO:0000176
name: N-acetylglucosaminylphosphatidylinositol deacetylase
kinetic law: MODEL1310110024#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.1.89
fast: false
notes: GENE_ASSOCIATION: (9487.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.5.1.89 Confidence Level: 4 AUTHORS: PMID:10085243,PMID:14742432 NOTES:NCD
modifier: MODEL1310110024#
type: Reaction
reversible: false

metaR ASCBOX
fast: false
type: Reaction
reactant: MODEL1310110024#
reversible: false
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110024#
is: SBO:0000176
name: ascorbic acid oxidase
is described by: ECO:0000000

metaR NAHCO3 HCLt
name: bicarbonate transport (HCl/NaHCO3 exchange)
modifier: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
fast: false
is: SBO:0000185
reactant: MODEL1310110024#
reversible: true

metaR r2535
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110024#
reversible: true
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
type: Reaction
reactant: MODEL1310110024#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1

http://identifiers.org/biomodels.db/MODEL1310110024#_7e6af3ad_9a4e_450c_af25_38b15d58cef9
initial concentration: NaN
has only substance units: false
boundary condition: true
name: ENTPD3
constant: false
is: O75355
is encoded by: hsa:956
type: Species
initial amount: NaN
is: SBO:0000252

metaR RDH3a
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.300
modifier: MODEL1310110024#
fast: false
product: MODEL1310110024#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (112724.1) or (145226.1) or (51109.1) or (57665.1) or (195814.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
name: retinol dehydrogenase (11-cis,NADPH)
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.1.1.105
reversible: true

metaM hs deg18 l
constant: false
type: Species
is: CHEBI:17180
initial amount: NaN
boundary condition: false
is: HMDB01352
name: heparan sulfate, degradation product 18
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C43H66N2O45S3 CHARGE: -4

metaR r2321
type: Reaction
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110024#
is: SBO:0000185
reactant: MODEL1310110024#
reversible: true
is described by: ECO:0000000
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR r2101
reversible: true
kinetic law: MODEL1310110024#
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110024#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110024#
modifier: MODEL1310110024#

metaM dolglcp L c
is: CHEBI:15812
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN

metaR G14T5g
is: SBO:0000176
product: MODEL1310110024#
is described by: ECO:0000000
reversible: false
fast: false
kinetic law: MODEL1310110024#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.2) or (8704.1) or (8703.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
modifier: MODEL1310110024#

metaM oagd3 hs c
is: CHEBI:58367
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
name: 9-O-Acetylated GD3
is: HMDB00286
is: C00029
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_023d3143_4645_4445_8173_30df55566271
initial amount: NaN
has only substance units: false
name: _BF195998_1_x
constant: false
is encoded by: hsa:BF195998
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaM Tn antigen g
type: Species
boundary condition: false
is: C04383
initial concentration: 1.0
constant: false
notes: FORMULA: C8H14NO5X CHARGE: 0
has only substance units: false
name: Tn antigen
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_31aa18dd_0607_4e76_9327_325d58fc9131
boundary condition: true
name: NOS3
constant: false
has only substance units: false
type: Species
is encoded by: hsa:4846
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: A0S0A7

metaM 4mzym int2 r
type: Species
boundary condition: false
notes: FORMULA: C28H44O CHARGE: 0 INCHI: InChI=1/C28H44O/c1-18(2)8-7-9-19(3)22-12-13-24-21-10-11-23-20(4)26(29)15-17-28(23,6)25(21)14-16-27(22,24)5/h8,19-20,22-24H,7,9-17H2,1-6H3/t19-,20?,22?,23?,24?,27-,28+/m1/s1
constant: false
is: HMDB06838
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: 4-Methylzymosterol intermediate 2

metaR ELAIDCPT2
reversible: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine transferase
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
modifier: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_a1f8fb1e_d074_4705_822f_b55638621153
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:18
has only substance units: false
name: ABAT
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110024#_ad06b380_4a21_4942_869e_a49a583305b8
boundary condition: true
type: Species
name: SLC27A1
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:376497
initial amount: NaN
has only substance units: false

metaM ttetddcoa m
is: SBO:0000247
type: Species
has only substance units: false
constant: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
is: HMDB02288
initial concentration: 1.0
boundary condition: false
name: trans5,8tetradecadienoylcoa
initial amount: NaN

metaR r2534
fast: false
kinetic law: MODEL1310110024#
is: SBO:0000185
reactant: MODEL1310110024#
type: Reaction
product: MODEL1310110024#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

metaR r2320
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110024#
is: SBO:0000185
reactant: MODEL1310110024#
type: Reaction
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR r0639
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
name: Lauroyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
product: MODEL1310110024#
is: SBO:0000176
reversible: false

metaR EX dopasf LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine 3-O-sulfate exchange
type: Reaction

metaM hs deg5 l
is: HMDB00158
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:17895
name: heparan sulfate, degradation product 5
notes: FORMULA: C67H97N4O86S10 CHARGE: -11
has only substance units: false
initial amount: NaN

metaR r2100
reactant: MODEL1310110024#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110024#
reversible: true
is described by: ECO:0000000
product: MODEL1310110024#
type: Reaction
kinetic law: MODEL1310110024#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR OAGD3tg
is described by: ECO:0000000
fast: false
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
reversible: true
kinetic law: MODEL1310110024#
type: Reaction
name: oagd3 hs intracellular transport
is: SBO:0000185
reactant: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_d997f640_5c3c_46c9_874a_08f78f37ad6d
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
name: UROD
is: P06132
is encoded by: hsa:7389

metaM sphings l
type: Species
constant: false
has only substance units: false
is: CHEBI:57756
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
is: SBO:0000247
name: sphingosine(1+)
initial concentration: 1.0
is: HMDB00252
initial amount: NaN
boundary condition: false

metaM camp c
is: CHEBI:58165
boundary condition: false
notes: FORMULA: C10H11N5O6P CHARGE: -1 INCHI: InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/p-1/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00434 EHMN_ABBREVIATION: C00575
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB00058
initial concentration: 1.0
name: 3',5'-cyclic AMP(1-)
type: Species

metaR CYTK7n
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
name: cytidylate kinase (CMP,UTP),nuclear
reactant: MODEL1310110024#
fast: false

metaM HC02180 c
type: Species
is: SBO:0000247
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
initial amount: NaN
constant: false
name: thromboxane-b2
is: CHEBI:28728
boundary condition: false
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110024#_a76cc10a_54f4_4b9d_b39e_08e74dea7ec9
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:10327
name: AKR1A1
initial amount: NaN
constant: false
initial concentration: NaN
is: P14550
boundary condition: true

metaR MAL Lte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
reversible: true
name: Transport of L-malate
type: Reaction
kinetic law: MODEL1310110024#
is described by: ECO:0000134
product: MODEL1310110024#
reactant: MODEL1310110024#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110024#_11242a84_ca3c_4b37_aea7_c50a97605cdc
constant: false
has only substance units: false
name: CHKA
boundary condition: true
initial amount: NaN
is encoded by: hsa:1119
initial concentration: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_5fa5cb77_6e38_4405_88bc_1fb6f745ab98
is: Q6ZWP6
boundary condition: true
type: Species
has only substance units: false
constant: false
initial concentration: NaN
name: ACAD8
is encoded by: hsa:27034
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110024#_82a06731_0593_48d4_8cbc_14fb255f4d20
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:1431
initial amount: NaN
name: CS

http://identifiers.org/biomodels.db/MODEL1310110024#_6894943e_a5ac_4192_a403_b7f4b1f03386
is: B2R6S5
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:51727
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: CMPK1

metaR r2308
product: MODEL1310110024#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
kinetic law: MODEL1310110024#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:

metaM dag hs e
initial concentration: 1.0
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
name: diglyceride
initial amount: NaN
constant: false
is: CHEBI:18035
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110024#_7d15f66d_5054_4fac_be97_d301a7933e9d
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
name: AMY1C
is encoded by: hsa:278
initial concentration: NaN
is: P04745

metaM dmnoncoa m
type: Species
name: 4,8 dimethylnonanoyl-CoA
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
is: HMDB11604
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_41869209_bd64_482d_9926_17b0f9fa13da
is encoded by: hsa:8693
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: Q8N4A0
name: GALNT4
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_b791de0e_2bba_441f_a6d1_c4b7fdb4a9f1
boundary condition: true
constant: false
name: PMVK
is encoded by: hsa:10654
type: Species
initial concentration: NaN
is: Q6FGV9
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaR PROSTGE2t
type: Reaction
name: prostaglandin transport via bicarbonate countertransport
reactant: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
kinetic law: MODEL1310110024#
product: MODEL1310110024#
is described by: ECO:0000269
reversible: true
is: SBO:0000185
modifier: MODEL1310110024#

metaR G14T21g
product: MODEL1310110024#
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110024#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110024#

metaR URCN
is described by: ECO:0000269
name: URCN
notes: GENE_ASSOCIATION: (131669.1) SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/4.2.1.49
reversible: false
modifier: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
fast: false
type: Reaction

metaM HC00342 m
constant: false
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
is: SBO:0000247
is: CHEBI:16383
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: cis-aconitate(3-)
has only substance units: false

metaM 3dpdhb m
initial amount: NaN
is: CHEBI:50775
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C57H85O4 CHARGE: -1 INCHI: InChI=1S/C57H86O4/c1-43(2)21-12-22-44(3)23-13-24-45(4)25-14-26-46(5)27-15-28-47(6)29-16-30-48(7)31-17-32-49(8)33-18-34-50(9)35-19-36-51(10)37-20-38-52(11)39-40-53-41-54(57(60)61)42-55(58)56(53)59/h21,23,25,27,29,31,33,35,37,39,41-42,58-59H,12-20,22,24,26,28,30,32,34,36,38,40H2,1-11H3,(H,60,61)/b44-23+,45-25+,46-27+,47-29+,48-31+,49-33+,50-35+,51-37+,52-39+
type: Species
has only substance units: false
initial concentration: 1.0
name: 3-Decaprenyl-4,5-dihdydroxybenzoate

metaM HC02217 c
constant: false
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:27647
initial concentration: 1.0
name: prostaglandin-g2
boundary condition: false
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
initial amount: NaN

metaM adrnl c
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C9H14NO3 CHARGE: 1 INCHI: InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3 EHMN_ABBREVIATION: C00788
type: Species
name: Adrenaline
initial amount: NaN
is: CHEBI:33568
is: HMDB00068
has only substance units: false
initial concentration: 1.0

metaR r0870
product: MODEL1310110024#
type: Reaction
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.6.1.1
is version of: http://identifiers.org/ec-code/3.6.4.13
is version of: http://identifiers.org/ec-code/2.7.7.72
reversible: true
fast: false
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.1.3.4
is described by: ECO:0000000
name: Facilitated diffusion

metaR RDH1a
notes: GENE_ASSOCIATION: (157506.1) or (112724.1) or (145226.1) or (51109.1) or (195814.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12407145,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
product: MODEL1310110024#
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.1.1.105
reversible: true
is: SBO:0000176
modifier: MODEL1310110024#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.300
fast: false
reactant: MODEL1310110024#
name: retinol dehydrogenase (all-trans,NADPH)

metaR r2309
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
product: MODEL1310110024#
is described by: ECO:0000000
kinetic law: MODEL1310110024#
is: SBO:0000185
reversible: true
reactant: MODEL1310110024#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaM nrpphr c
has only substance units: false
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
is: SBO:0000247
name: Norepinephrine
is: CHEBI:33569
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00216
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_8dda3747_8c9d_4bd7_8d2f_67d82af4cc0b
constant: false
is: SBO:0000252
is: Q9Y233
is encoded by: hsa:10846
type: Species
initial concentration: NaN
initial amount: NaN
name: PDE10A
has only substance units: false
boundary condition: true

metaR PPBNGS
reversible: false
type: Reaction
is: SBO:0000176
product: MODEL1310110024#
name: porphobilinogen synthase
is version of: http://identifiers.org/ec-code/4.2.1.24
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (210.1) or (210.2) SUBSYSTEM: Heme synthesis EC Number: 4.2.1.24 Confidence Level: 4 AUTHORS: NOTES:
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_bd616519_08a7_494f_bc07_6dcb4bd527e6
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4830
initial amount: NaN
constant: false
type: Species
name: NME1
boundary condition: true
initial concentration: NaN

metaR r2532
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is: SBO:0000185
kinetic law: MODEL1310110024#
fast: false
reactant: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

metaR PROSTGI2tr
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110024#
product: MODEL1310110024#
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
reversible: true
is described by: ECO:0000269
name: Prostaglandin I2 transport (ER)

metaR HOXG
name: Heme oxygenase 1
is described by: ECO:0000134
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (3162.1) or (3163.1) SUBSYSTEM: Heme degradation EC Number: 1.14.99.3 Confidence Level: 0 AUTHORS: PMID:16356137 NOTES:TDV (4/28/2004) There are conflicting data on how many moles of NADPH consumed per mole of Biliverdine (Tenhunen 1969, Ryter, 2000). Heme oxygenase is a well known enzyme
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.14.99.3
type: Reaction
is: SBO:0000176
fast: false
reversible: false
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_a97e3603_47f5_4db9_86bf_2f269ad16237
name: ALG8
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is: Q9BVK2
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:79053

metaM adrncrn m
initial concentration: 1.0
is: C00318
constant: false
is: HMDB00062
has only substance units: false
name: Adrenyl carnitine
notes: FORMULA: C29H49NO4 CHARGE: 0
initial amount: NaN
is: CHEBI:16347
is: SBO:0000247
type: Species
boundary condition: false

metaM c226crn c
constant: false
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB06510
boundary condition: false
name: cervonyl carnitine
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
is: http://identifiers.org/pubchem.compound/127055

metaR r0871
is: SBO:0000185
fast: false
name: Diffusion
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409 NOTES:
reversible: true
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000000
type: Reaction

metaM arg L m
boundary condition: false
name: L-argininium(1+)
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:32682
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
type: Species
is: HMDB00517

http://identifiers.org/biomodels.db/MODEL1310110024#_476e0285_bb8c_4b4a_a6aa_392225893566
is encoded by: hsa:4717
constant: false
name: NDUFC1
initial amount: NaN
is: SBO:0000252
is: O43677
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110024#_b27686f7_59ff_4d44_8b75_51625d225960
has only substance units: false
boundary condition: true
name: _AI971036_1_m
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:AI971036

metaM dece4coa x
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
name: 4-decenoylcoa
initial amount: NaN
constant: false
is: HMDB02145

http://identifiers.org/biomodels.db/MODEL1310110024#_0d062543_26df_4720_9345_e157a80ad185
name: ST3GAL3
initial amount: NaN
boundary condition: true
is: B4DX62
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:6487

metaM HC02217 e
constant: false
name: prostaglandin-g2
is: CHEBI:27647
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
type: Species
has only substance units: false
initial amount: NaN

metaR RE0691C
name: RE0691
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
product: MODEL1310110024#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:

metaM cytd m
notes: FORMULA: C9H13N3O5 CHARGE: 0 INCHI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
initial concentration: 1.0
name: cytidine
has only substance units: false
is: SBO:0000247
is: CHEBI:17562
initial amount: NaN
is: HMDB00089
type: Species
constant: false
boundary condition: false

metaM dag hs c
has only substance units: false
type: Species
name: diglyceride
constant: false
is: CHEBI:18035
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0

metaR ITPtn
fast: false
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185
is described by: ECO:0000000
reversible: true
name: ITP nuclear transport
type: Reaction
product: MODEL1310110024#
reactant: MODEL1310110024#

metaR ALASm
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.3.1.37
fast: false
product: MODEL1310110024#
name: 5-aminolevulinate synthase
is described by: ECO:0000254
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.29
modifier: MODEL1310110024#
reversible: false
type: Reaction
reactant: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_81eb032a_9003_48d4_babe_429fb74b8247
type: Species
name: BCKDHB
boundary condition: true
is encoded by: hsa:594
initial amount: NaN
constant: false
is: SBO:0000252
is: P21953
initial concentration: NaN
has only substance units: false

metaR UMPK6
kinetic law: MODEL1310110024#
type: Reaction
reactant: MODEL1310110024#
modifier: MODEL1310110024#
reversible: true
product: MODEL1310110024#
name: UMP kinase (dCTP)
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
is described by: ECO:0000269

metaR ADK1m
modifier: MODEL1310110024#
reversible: true
name: adenylate kinase, mitochondrial
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (205.3) or (205.1) or (204.1) or (204.3) or (204.2) or (205.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:11485571,PMID:195572,PMID:8843353,PMID:9434148 NOTES:NCD
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.3
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
product: MODEL1310110024#

metaM duri e
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
name: Deoxyuridine
is: C00526
initial amount: NaN
type: Species
is: HMDB00012
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16450
boundary condition: false
has only substance units: false
constant: false

metaM tyr L m
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
constant: false
is: CHEBI:17895
type: Species
is: SBO:0000247
is: HMDB00158
has only substance units: false
boundary condition: false
name: L-tyrosine
initial amount: NaN
initial concentration: 1.0

metaR r0643
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
product: MODEL1310110024#
is: SBO:0000176
kinetic law: MODEL1310110024#
reversible: true
type: Reaction
is described by: ECO:0000000
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
reactant: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_c187473b_38ed_405e_9b44_70ad82a307f2
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
name: _D29675_1_e
initial concentration: NaN
is encoded by: hsa:D29675
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_385ee7db_b5f8_4e0c_be7d_4bc56545de6c
initial concentration: NaN
is: SBO:0000252
name: _FLJ44968_1_m
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:FLJ44968

metaM crn e
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
is: C00318
name: L-Carnitine
is: HMDB00062
is: CHEBI:16347
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318

http://identifiers.org/biomodels.db/MODEL1310110024#_898a2a93_e9a7_413d_a703_412ec4757d73
constant: false
is encoded by: hsa:4967
is: SBO:0000252
initial concentration: NaN
name: OGDH
type: Species
initial amount: NaN
is: Q02218
boundary condition: true
has only substance units: false

metaM cs e deg6 l
initial amount: NaN
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 6
is: SBO:0000247
notes: FORMULA: C31H48NO32S2 CHARGE: -3
is: HMDB01354
is: CHEBI:57455

metaM xu5p D c
initial concentration: 1.0
has only substance units: false
name: D-xylulose 5-phosphate(2-)
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:57737
boundary condition: false
constant: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
is: HMDB00868

http://identifiers.org/biomodels.db/MODEL1310110024#_d21200a5_f9dd_4b6a_81e2_79894d9a3dbe
name: RRM2
is: P31350
constant: false
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:6241
is: SBO:0000252

metaR XYLtly
is: SBO:0000185
reversible: false
reactant: MODEL1310110024#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
name: Xylose efflux from lysosome
kinetic law: MODEL1310110024#
product: MODEL1310110024#
fast: false
type: Reaction

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

metaM ksii core2 pre7 g
initial concentration: 1.0
notes: FORMULA: C67H108N5O51SX CHARGE: -2
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:58053
type: Species
is: HMDB00175
is: C00130
boundary condition: false
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 7

http://identifiers.org/biomodels.db/MODEL1310110024#_12edd3c4_2dc8_4511_b7cd_ca86441da938
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
is: P00338
boundary condition: true
name: LDHA
is encoded by: hsa:3939
initial amount: NaN

metaR UMPK7
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
modifier: MODEL1310110024#
reversible: true
name: UMP kinase (dGTP)
kinetic law: MODEL1310110024#
is: SBO:0000176
reactant: MODEL1310110024#
product: MODEL1310110024#

metaR r0644
is: SBO:0000176
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110024#
kinetic law: MODEL1310110024#
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1

metaM hdd2coa m
is: HMDB03945
name: trans-Hexadec-2-enoyl-CoA
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
is: C05272
is: CHEBI:61526
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaM retinal cis 9 c
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
is: HMDB01358
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:17898
constant: false
name: all-trans-retinal
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR PPCDC
is described by: ECO:0000269
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 4 AUTHORS: PMID:11923312 NOTES:
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
fast: false
name: phosphopantothenoylcysteine decarboxylase
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/4.1.1.36
is: SBO:0000176

metaM 4mop c
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
is: HMDB00695
constant: false
initial concentration: 1.0
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
name: 4-methyl-2-oxopentanoate
is: CHEBI:17865

metaR 3AIB Dtm
fast: false
name: transport of 3aib_D into mitochondria
is described by: ECO:0000134
is: SBO:0000185
type: Reaction
product: MODEL1310110024#
kinetic law: MODEL1310110024#
reversible: true
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: no transporter could be identified, so diffusion is assumed. NOTES:

metaR EX co LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Carbon monoxide exchange
type: Reaction

metaM ksii core2 pre9 g
is: CHEBI:28067
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
name: keratan sulfate II biosynthesis, precursor 9
is: SBO:0000247
notes: FORMULA: C75H120N6O59S2X CHARGE: -3
type: Species

metaM duri c
is: CHEBI:16450
is: HMDB00012
boundary condition: false
has only substance units: false
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
is: C00526
type: Species
name: Deoxyuridine

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaM HC02180 e
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
is: SBO:0000247
is: CHEBI:28728
type: Species
has only substance units: false
name: thromboxane-b2

http://identifiers.org/biomodels.db/MODEL1310110024#_f5656082_a2c9_4a81_bbff_682206d9c0a2
constant: false
has only substance units: false
name: ADCY6
boundary condition: true
is encoded by: hsa:112
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
is: O43306

metaM g2m8masn r
is: SBO:0000247
notes: FORMULA: C82H137N2O65X CHARGE: 0
initial concentration: 1.0
constant: false
boundary condition: false
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
has only substance units: false
is: C05874
type: Species
initial amount: NaN

metaR HS4ly
reactant: MODEL1310110024#
is described by: ECO:0000000
kinetic law: MODEL1310110024#
name: heparan-N-sulfatase, lysosomal
type: Reaction
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
reversible: false
modifier: MODEL1310110024#
product: MODEL1310110024#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.10.1.1

http://identifiers.org/biomodels.db/MODEL1310110024#_269e5ab0_e293_4916_87c0_09f191528670
is encoded by: hsa:9962
type: Species
initial amount: NaN
name: SLC23A2
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN

metaR r2029
fast: false
type: Reaction
reactant: MODEL1310110024#
product: MODEL1310110024#
is described by: ECO:0000000
modifier: MODEL1310110024#
is: SBO:0000185
kinetic law: MODEL1310110024#
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM crn c
is: CHEBI:16347
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial amount: NaN
is: HMDB00062
is: C00318
is: SBO:0000247
name: L-Carnitine
type: Species

metaR C161CRNt
product: MODEL1310110024#
name: C161 transport into the mitochondria
reversible: false
fast: false
reactant: MODEL1310110024#
is described by: ECO:0000000
modifier: MODEL1310110024#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:TDV

metaR RE0344C
is described by: ECO:0000000
reversible: true
fast: false
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.3.1.65
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.1.2.2
type: Reaction
is: SBO:0000176
name: RE0344
reactant: MODEL1310110024#

metaR r1809
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110024#
is described by: ECO:0000000
product: MODEL1310110024#
reversible: false
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110024#_0060159a_29ae_4f0d_91b7_3ee756da2101
has only substance units: false
name: CA6
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is: Q5FC00
is encoded by: hsa:765
boundary condition: true
constant: false

metaM cala c
is: SBO:0000247
is: HMDB00026
is: CHEBI:11892
has only substance units: false
notes: FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642
initial concentration: 1.0
initial amount: NaN
type: Species
name: N-carbamoyl-beta-alaninate
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110024#_489858f4_af29_4a62_a957_41a39e1ffc09
has only substance units: false
has part: Q9P2X0
is encoded by: hsa:54344
constant: false
type: Species
is encoded by: hsa:8818
is: SBO:0000297
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: DPM3:DPM1:DPM2

metaR S4TASE3ly
product: MODEL1310110024#
is: SBO:0000176
name: N-acetylgalactosamine-4-sulfatase, lysosomal
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.12
is described by: ECO:0000000
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
modifier: MODEL1310110024#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110024#_44d0442c_871e_4d98_9344_169e32d82a0c
is: SBO:0000252
type: Species
is encoded by: hsa:6392
initial concentration: NaN
boundary condition: true
constant: false
is: O14521
has only substance units: false
initial amount: NaN
name: SDHD

http://identifiers.org/biomodels.db/MODEL1310110024#_2939f1c4_0588_452b_bdb1_bc4a9a7202b8
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is: O95167
constant: false
name: NDUFA3
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4696

metaR DNDPt27m
fast: false
name: dCDP transport via dTDP antiport
modifier: MODEL1310110024#
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
is: SBO:0000185

metaM dmnoncoa c
is: HMDB11604
has only substance units: false
constant: false
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
name: 4,8 dimethylnonanoyl-CoA

metaM arg L c
is: SBO:0000247
is: HMDB00517
type: Species
has only substance units: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
boundary condition: false
initial amount: NaN
name: L-argininium(1+)
is: CHEBI:32682
initial concentration: 1.0
constant: false

metaR r0752
kinetic law: MODEL1310110024#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
reactant: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:
fast: false
modifier: MODEL1310110024#
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is: SBO:0000176

metaM thyox L e
is: HMDB00248
type: Species
name: L-thyroxine
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:18332
constant: false

metaM fad e
is: HMDB01248
is: CHEBI:16238
has only substance units: false
constant: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: SBO:0000247
initial concentration: 1.0
is: C00016
name: Flavin adenine dinucleotide oxidized
initial amount: NaN
type: Species
boundary condition: false

metaR UMPK2
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110024#
type: Reaction
fast: false
modifier: MODEL1310110024#
name: UMP kinase (CTP)
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
reversible: true
is: SBO:0000176

metaM dag hs n
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
name: diglyceride
boundary condition: false
is: CHEBI:18035
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
has only substance units: false

metaR UDPGD
is version of: http://identifiers.org/ec-code/1.1.1.22
type: Reaction
product: MODEL1310110024#
is: SBO:0000176
modifier: MODEL1310110024#
is described by: ECO:0000304
name: UDPglucose 6-dehydrogenase
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (7358.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 1.1.1.22 Confidence Level: 2 AUTHORS: PMID:9296457,PMID:9737970 NOTES:JLR
reactant: MODEL1310110024#
reversible: false
fast: false

metaM cytd c
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
is: C00475
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB00089
name: Cytidine
is: CHEBI:17562
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_e7d10452_0754_4f64_bec5_d63aa01a7ca1
initial concentration: NaN
name: PPAP2B
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:8613
constant: false
is: SBO:0000252
type: Species
is: O14495

metaM dece4coa m
is: HMDB02145
name: 4-decenoylcoa
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
initial concentration: 1.0
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110024#_e0d94300_57e3_4407_b9fc_15429f151810
boundary condition: true
name: ATP5I
initial concentration: NaN
type: Species
is encoded by: hsa:521
is: P56385
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaM CE5586 c
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
name: N-[(E)-4-ammoniobutylidene]propane-1,3-diaminium
boundary condition: false
is: CHEBI:58732
constant: false
notes: FORMULA: C7H20N3 CHARGE: 3 INCHI: InChI=1S/C7H17N3/c8-4-1-2-6-10-7-3-5-9/h6H,1-5,7-9H2/p+3/b10-6+ EHMN_ABBREVIATION: CE5586
initial amount: NaN

metaR HISSNAT5tc
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_28f6fc3a_f50a_4bec_b712_fcd41e37fa03
is encoded by: hsa:6713
boundary condition: true
initial concentration: NaN
name: SQLE
initial amount: NaN
constant: false
has only substance units: false
is: Q5HYI4
is: SBO:0000252
type: Species

metaR ALADGLNexR
fast: false
reactant: MODEL1310110024#
is: SBO:0000185
product: MODEL1310110024#
name: L-alanine/glutamine reversible exchange
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110024#
type: Reaction
is described by: ECO:0000304
reversible: true

metaM cgly c
has only substance units: false
is: HMDB00078
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:4047
boundary condition: false
name: L-cysteinylglycine
constant: false
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419

metaR r0753
is: SBO:0000176
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
modifier: MODEL1310110024#
product: MODEL1310110024#
kinetic law: MODEL1310110024#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
reactant: MODEL1310110024#
fast: false

metaR ABTti
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
reactant: MODEL1310110024#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false
name: L-arabinitol transport via passive diffusion
reversible: false

metaM ksi deg16 l
is: HMDB01354
is: SBO:0000247
name: keratan sulfate I, degradation product 16
constant: false
is: CHEBI:57455
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C160H258N11O137S7 CHARGE: -7
initial amount: NaN
boundary condition: false

metaR UMPK3
type: Reaction
name: UMP kinase (UTP)
is described by: ECO:0000269
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110024#
reversible: true
is: SBO:0000176
fast: false
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.7.4.14

http://identifiers.org/biomodels.db/MODEL1310110024#_905a932e_61da_4e3a_9494_59ff562a9dc1
boundary condition: true
type: Species
is: SBO:0000252
constant: false
name: AK4
initial concentration: NaN
has only substance units: false
is: P27144
initial amount: NaN
is encoded by: hsa:205

http://identifiers.org/biomodels.db/MODEL1310110024#_d4916175_1c5e_497e_845e_046d4d2f601a
name: BTD
initial concentration: NaN
is: SBO:0000252
is: P43251
initial amount: NaN
is encoded by: hsa:686
type: Species
has only substance units: false
boundary condition: true
constant: false

metaR ARAB Lt
kinetic law: MODEL1310110024#
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110024#
reactant: MODEL1310110024#
name: L-arabinoase extracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12359133,PMID:15234337,PMID:2167807 NOTES:
reversible: true

metaM cgly e
boundary condition: false
is: HMDB00078
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:4047
has only substance units: false
initial amount: NaN
type: Species
name: L-cysteinylglycine
constant: false
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419

metaM arg L e
initial amount: NaN
constant: false
is: CHEBI:32682
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: SBO:0000247
is: HMDB00517
name: L-argininium(1+)
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaM his L m
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
initial amount: NaN
is: HMDB00177
name: L-histidine
is: CHEBI:15971
has only substance units: false

metaM pre prot r
name: glycophosphatidylinositol (GPI)-anchored protein precursor
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: XY CHARGE: 0
is: CHEBI:16038
boundary condition: false

metaR r0641
kinetic law: MODEL1310110024#
product: MODEL1310110024#
is: SBO:0000176
reversible: true
modifier: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
reactant: MODEL1310110024#
is described by: ECO:0000000
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.2.4

http://identifiers.org/biomodels.db/MODEL1310110024#_ff0871a8_f1e7_4718_a8c5_63a027ff02a1
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: LDHC
boundary condition: true
initial concentration: NaN
is encoded by: hsa:3948
is: P07864

metaR r0754
modifier: MODEL1310110024#
type: Reaction
is described by: ECO:0000000
fast: false
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
reversible: true
product: MODEL1310110024#
kinetic law: MODEL1310110024#
is: SBO:0000176
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.3.1.85

metaM thyox L c
name: L-thyroxine
is: HMDB00248
initial amount: NaN
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
is: SBO:0000247
constant: false
is: CHEBI:18332
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false

metaR r0879
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11287335,PMID:11327718 NOTES:
reversible: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: TCDB:2.A.29.2.4 TCDB:2.A.29.16.1
product: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false
reactant: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_729b56d3_5bcb_49f4_9f47_b28183f00572
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
name: ALDOA
is encoded by: hsa:226
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_c28a9756_54cb_4a55_9547_264b11de2986
initial amount: NaN
type: Species
name: SDHA
initial concentration: NaN
is encoded by: hsa:6389
constant: false
is: SBO:0000252
is: P31040
has only substance units: false
boundary condition: true

metaM fad c
has only substance units: false
initial amount: NaN
is: CHEBI:16238
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: HMDB01248
initial concentration: 1.0
constant: false
is: SBO:0000247
name: Flavin adenine dinucleotide oxidized
is: C00016
boundary condition: false
type: Species

metaR UMPK4
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110024#
fast: false
reactant: MODEL1310110024#
modifier: MODEL1310110024#
is described by: ECO:0000269
name: UMP kinase (GTP)
kinetic law: MODEL1310110024#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM cytd e
is: SBO:0000247
is: C00475
is: HMDB00089
initial concentration: 1.0
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
boundary condition: false
has only substance units: false
is: CHEBI:17562
initial amount: NaN
name: Cytidine
type: Species
constant: false

metaR THRALANaEx
kinetic law: MODEL1310110024#
is: SBO:0000185
reactant: MODEL1310110024#
name: L-alanine/L-threonine Na-dependent exchange (Thr-L in)
modifier: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
product: MODEL1310110024#
is described by: ECO:0000269
fast: false

metaR TSTSTERONEtr
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is described by: ECO:0000000
product: MODEL1310110024#
fast: false
name: testosterone intracellular transport
reversible: true
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
type: Reaction

metaR r0642
is: SBO:0000176
reversible: true
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
kinetic law: MODEL1310110024#
is described by: ECO:0000000
product: MODEL1310110024#
type: Reaction
fast: false
reactant: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_ae2756af_0b47_4f7e_a1c5_4a4f7aa9d7b0
constant: false
initial concentration: NaN
is encoded by: hsa:79053
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: A6NDW6
name: ALG8
type: Species

metaM leuktrE4 e
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:57462
has only substance units: false
name: leukotriene E4(1-)
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
is: HMDB02200

metaM mescon m
is: HMDB00749
has only substance units: false
is: SBO:0000247
name: Mesaconate
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
boundary condition: false
is: CHEBI:36986
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species

metaR r0755
type: Reaction
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (37.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:1898068 NOTES:
is described by: ECO:0000000
product: MODEL1310110024#
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
reversible: true
fast: false
is: SBO:0000176

metaR RE3347C
product: MODEL1310110024#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
is: SBO:0000176
name: RE3347
reversible: true
kinetic law: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_1cdc19c1_44c2_4fff_b141_03599eb5b9d3
is encoded by: hsa:5209
has only substance units: false
boundary condition: true
constant: false
name: PFKFB3
initial amount: NaN
type: Species
is: Q16875
is: SBO:0000252
initial concentration: NaN

metaR UMPK5
is described by: ECO:0000269
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110024#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110024#
fast: false
reversible: true
reactant: MODEL1310110024#
name: UMP kinase (dATP)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_d2db3cb6_efc5_47a1_9eee_905f1c41e258
initial amount: NaN
is: SBO:0000252
constant: false
name: B3GNT6
type: Species
is: A8K9Q8
is encoded by: hsa:192134
initial concentration: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_403acfe9_fb9e_4b14_a8d0_e31cb8042b37
boundary condition: true
is: O43252
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:9061
type: Species
has only substance units: false
name: PAPSS1
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_c633ed6b_04d2_46e2_8f42_8e18db4c9f2f
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
name: GPX3
type: Species
is: P22352
initial concentration: NaN
is encoded by: hsa:2878

http://identifiers.org/biomodels.db/MODEL1310110024#_5733c797_bbe6_40b5_bd83_f941676aa3ef
constant: false
is encoded by: hsa:728226
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: _728226_1_m
type: Species

metaM mlthf m
boundary condition: false
type: Species
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
is: HMDB01533
constant: false
initial amount: NaN
is: C00143
is: SBO:0000247
is: CHEBI:15636
initial concentration: 1.0
name: 5,10-Methylenetetrahydrofolate
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_1f60d584_2c29_47c9_8ad4_00d952e420a4
name: ATP5G1
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:516
initial concentration: NaN
initial amount: NaN
is: P05496
is: SBO:0000252
constant: false

metaR M13N2Tg
is: SBO:0000176
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.101
product: MODEL1310110024#
modifier: MODEL1310110024#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (4245.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.101 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
name: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

http://identifiers.org/biomodels.db/MODEL1310110024#_2ef9f214_2765_4237_9e7e_87e1a2c3f0b5
has only substance units: false
is: SBO:0000252
name: _AA278423_1_m
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AA278423
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_0d741902_5aee_4760_a441_9679bc986557
is: SBO:0000252
is: Q9ULD0
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: OGDHL
constant: false
is encoded by: hsa:55753

metaM zymst r
initial concentration: 1.0
is: CHEBI:18252
boundary condition: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437
is: HMDB06271
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: zymosterol
constant: false
type: Species

metaM ksi pre10 g
notes: FORMULA: C129H209N9O98S2X CHARGE: -3
is: SBO:0000247
constant: false
name: keratan sulfate I biosynthesis, precursor 10
initial concentration: 1.0
is: HMDB00175
is: CHEBI:58053
has only substance units: false
is: C00130
type: Species
boundary condition: false
initial amount: NaN

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

metaR GLYCTO1p
product: MODEL1310110024#
fast: false
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
reversible: false
notes: GENE_ASSOCIATION: (51179.1) or (54363.1) or (51179.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:tv NCD
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.3.15
name: Glycolate oxidase, peroxisome
modifier: MODEL1310110024#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_e365e98a_e2d5_441b_98e1_41aa5762ed64
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5730
has only substance units: false
boundary condition: true
name: PTGDS
constant: false
is: P41222
initial amount: NaN
type: Species

metaM hs deg6 l
is: CHEBI:17180
is: HMDB01352
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C67H98N4O83S9 CHARGE: -10
initial concentration: 1.0
constant: false
name: heparan sulfate, degradation product 6

metaM crn m
has only substance units: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial amount: NaN
is: CHEBI:16347
type: Species
initial concentration: 1.0
name: L-Carnitine
is: HMDB00062
is: C00318
constant: false
boundary condition: false
is: SBO:0000247

metaR MI1345PP
is version of: http://identifiers.org/ec-code/3.1.3.36
product: MODEL1310110024#
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.1.3.86
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.56
reversible: false
type: Reaction
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
is: SBO:0000176
reactant: MODEL1310110024#
modifier: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_39ec1eac_b4a4_4d49_8261_a4dac2e25e1f
is: SBO:0000297
is encoded by: hsa:2588
has part: Q99519
has part: P16278
constant: false
boundary condition: true
name: GALNS:GLB1:NEU1:CTSA
has part: P10619
is encoded by: hsa:4758
is encoded by: hsa:5476
is encoded by: hsa:2720
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
has part: P34059

http://identifiers.org/biomodels.db/MODEL1310110024#_b2287627_d5ce_4e35_ae5e_71a8210ae43b
is: SBO:0000252
name: DCK
is encoded by: hsa:1633
is: P27707
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true

metaR BACCL
is version of: http://identifiers.org/ec-code/6.3.4.10
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
is: SBO:0000176
reactant: MODEL1310110024#
modifier: MODEL1310110024#
fast: false
product: MODEL1310110024#
kinetic law: MODEL1310110024#
type: Reaction
reversible: false
name: biotin-[acetyl-CoA-carboxylase] ligase
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110024#_9cbed7b2_5c02_4135_9ffb_e45f8bf42186
initial amount: NaN
name: ALDH3B1
is: SBO:0000252
boundary condition: true
is: P43353
has only substance units: false
is encoded by: hsa:221
type: Species
constant: false
initial concentration: NaN

metaM hs deg15 l
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:16126
constant: false
notes: FORMULA: C49H71N2O57S5 CHARGE: -7
name: heparan sulfate, degradation product 15
initial concentration: 1.0
is: SBO:0000247
type: Species

metaM 5fthf m
initial concentration: 1.0
initial amount: NaN
type: Species
name: 5-formyltetrahydrofolate(2-)
is: SBO:0000247
is: CHEBI:57457
constant: false
is: HMDB01562
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_e154859f_61f9_4a61_8adf_5920d3ced940
initial amount: NaN
constant: false
is encoded by: hsa:2593
name: GAMT
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR r0758
type: Reaction
name: 5-Hydroxyindoleacetaldehyde:NAD+ oxidoreductase Tryptophan metabolism EC:1.2.1.3
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110024#
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:8155713,PMID:8605195 NOTES:
fast: false
is: SBO:0000176
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.5.4.16

metaM nrpphr e
is: CHEBI:33569
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
boundary condition: false
name: Norepinephrine
constant: false
is: HMDB00216
initial concentration: 1.0
is: SBO:0000247

metaR RBK
type: Reaction
name: ribokinase
kinetic law: MODEL1310110024#
product: MODEL1310110024#
is: SBO:0000176
notes: GENE_ASSOCIATION: (64080.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
modifier: MODEL1310110024#
is described by: ECO:0000304
reactant: MODEL1310110024#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.15

metaM ksi deg34 l
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB01354
is: CHEBI:57455
is: SBO:0000247
notes: FORMULA: C76H126N5O59S1 CHARGE: -1
name: keratan sulfate I, degradation product 34
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_518dea51_3458_4ab8_bdac_82626db4948e
boundary condition: true
initial amount: NaN
is: Q969N2
type: Species
is: SBO:0000252
has only substance units: false
constant: false
name: PIGT
initial concentration: NaN
is encoded by: hsa:51604

metaM hdd2coa c
has only substance units: false
constant: false
is: CHEBI:61526
is: SBO:0000247
is: HMDB03945
initial amount: NaN
is: C05272
initial concentration: 1.0
name: trans-Hexadec-2-enoyl-CoA
type: Species
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
boundary condition: false

metaR GLCNACPT U
reactant: MODEL1310110024#
name: UDP-GlcNAc:dolichol-phosphate GlcNAc phosphotransferase (uterus)
kinetic law: MODEL1310110024#
is: SBO:0000176
product: MODEL1310110024#
is described by: ECO:0000000
type: Reaction
fast: false
reversible: false
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (1798.1) or (1798.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.7.8.15 Confidence Level: 0 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.8.15

http://identifiers.org/biomodels.db/MODEL1310110024#_71697fe1_52fa_49e5_9405_0f1295d56bc3
name: NDUFB10
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:4716
is: A8K761

http://identifiers.org/biomodels.db/MODEL1310110024#_0f43e4cf_33e1_4996_a4f3_9659963ec66b
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:205
has only substance units: false
is: SBO:0000252
type: Species
name: AK4
boundary condition: true

metaM hdcecrn m
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m1/s1
is: HMDB00222
type: Species
constant: false
initial concentration: 1.0
name: Hexadecenoyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110024#_3a8f5f76_b04d_4d3d_b8c9_c035b560a955
boundary condition: true
constant: false
type: Species
initial concentration: NaN
is: E7EPT3
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: ALDH7A1
is encoded by: hsa:501

metaM ksii core4 l
has only substance units: false
type: Species
is: CHEBI:17140
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: keratan sulfate II (core 4-linked)
constant: false
initial concentration: 1.0
is: HMDB01644

metaR RE1517M
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.13
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
is: SBO:0000176
name: RE1517
modifier: MODEL1310110024#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110024#_553cd929_46b5_4895_bcc7_3ed282810c5d
is: P15291
boundary condition: true
constant: false
is encoded by: hsa:2683
has only substance units: false
name: B4GALT1
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species

metaM pac c
is: SBO:0000247
initial concentration: 1.0
is: HMDB00209
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
boundary condition: false
has only substance units: false
is: CHEBI:18401
name: phenylacetate
initial amount: NaN
constant: false
type: Species

metaM btamp c
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
initial concentration: 1.0
is: CHEBI:3110
is: HMDB04220
initial amount: NaN
type: Species
name: Biotinyl-5'-AMP
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false

metaR PYRt2r
modifier: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
kinetic law: MODEL1310110024#
type: Reaction
product: MODEL1310110024#
reversible: true
is described by: ECO:0000269
name: pyruvate reversible transport via proton symport
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110024#_486ccf55_4d9f_48c6_b340_ec3b55eaeb28
name: MTMR3
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:8897
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR XOL27OHtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
product: MODEL1310110024#
kinetic law: MODEL1310110024#
name: 27 hydroxy cholesterol transport
type: Reaction
reactant: MODEL1310110024#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
fast: false

metaM udpacgal l
is: SBO:0000247
is: CHEBI:57847
constant: false
boundary condition: false
name: UDP-N-acetyl-D-galactosamine(2-)
is: HMDB00304
has only substance units: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
type: Species
initial amount: NaN
initial concentration: 1.0

metaR ARSA
reactant: MODEL1310110024#
fast: false
name: Arylsulfatase A
reversible: false
is: SBO:0000176
modifier: MODEL1310110024#
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.1.6.8
kinetic law: MODEL1310110024#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (410.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.6.8 Confidence Level: 4 AUTHORS: PMID:2562955 NOTES:NJ

metaR FAOXC164GC163m
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)gm
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_1a03cd1d_933f_42e5_b81a_d58867efec43
is: SBO:0000252
boundary condition: true
has only substance units: false
name: ENTPD3
initial concentration: NaN
is encoded by: hsa:956
constant: false
initial amount: NaN
is: O75355
type: Species

metaR GLYt7 311 r
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reversible: true
name: glycine reversible transport via sodium and chloride symport (3:1:1)
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
modifier: MODEL1310110024#
product: MODEL1310110024#
fast: false
is described by: ECO:0000006

metaM subeac x
initial concentration: 1.0
name: suberic acid
is: HMDB00893
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C8H12O4 CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110024#_79ddc692_7e74_498a_85e5_9295bcb699cf
has only substance units: false
boundary condition: true
constant: false
is: Q53G02
type: Species
name: DAD1
is encoded by: hsa:1603
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaM idour l
is: HMDB02704
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
is: CHEBI:21338
name: L-iduronate
constant: false
type: Species
has only substance units: false

metaM fad m
initial concentration: 1.0
constant: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
boundary condition: false
is: C00016
name: Flavin adenine dinucleotide oxidized
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB01248
is: CHEBI:16238
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_4e996068_ce28_41c9_91f7_d100861701c5
initial concentration: NaN
type: Species
name: SLC25A22
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
is: Q9H936
is encoded by: hsa:79751
is: SBO:0000252

metaM 34hpl m
notes: FORMULA: C9H9O4 CHARGE: -1 INCHI: InChI=1S/C9H10O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8,10-11H,5H2,(H,12,13)/p-1
is: CHEBI:36659
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB00755
name: 3-(4-hydroxyphenyl)lactate
type: Species
has only substance units: false
initial concentration: 1.0
constant: false

metaR CYTDtm
is: SBO:0000185
name: cytidine facilated transport in mitochondria
modifier: MODEL1310110024#
fast: false
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
product: MODEL1310110024#
type: Reaction
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110024#

metaR r1090
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: false
name: TCDB:2.A.47.1.9 TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
type: Reaction
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_f384c6a9_e988_4122_983a_6def669e5fcc
is encoded by: hsa:AI640625
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: _AI640625_1_c
has only substance units: false
type: Species
is: SBO:0000252
constant: false

metaM s7p c
constant: false
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382
is: C05382
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:57483
initial concentration: 1.0
is: HMDB01068
is: SBO:0000247
type: Species
name: Sedoheptulose 7-phosphate

http://identifiers.org/biomodels.db/MODEL1310110024#_11adb760_04d8_4c12_9229_38cfc773318b
is: Q70HW3
is encoded by: hsa:115286
type: Species
boundary condition: true
constant: false
initial concentration: NaN
name: SLC25A26
is: SBO:0000252
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_49d27588_4740_4178_b280_206d6d3cf107
is: Q6LEN5
is encoded by: hsa:1103
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
constant: false
name: CHAT

http://identifiers.org/biomodels.db/MODEL1310110024#_f03c8348_ad96_4371_b235_e95357c7fb59
type: Species
is encoded by: hsa:2585
is: Q01415
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: GALK2

metaR PNTK
product: MODEL1310110024#
is: SBO:0000176
modifier: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000269
name: pantothenate kinase
fast: false
reversible: false
notes: GENE_ASSOCIATION: (79646.1) or (80025.2) or (53354.1) or (53354.3) or (80025.1) or (53354.2) or (80025.3) or (80025.4) or (55229.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.7.1.33
type: Reaction

metaM nm4masn g
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C54H90N3O40X CHARGE: 0
is: C05882
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_05a82064_9dad_4942_8865_5b3f99372ed8
has only substance units: false
initial amount: NaN
name: ATP2B1
type: Species
boundary condition: true
is: P20020
initial concentration: NaN
is encoded by: hsa:490
constant: false
is: SBO:0000252

metaR r0424
kinetic law: MODEL1310110024#
fast: false
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.17.1.4
type: Reaction
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
reactant: MODEL1310110024#
reversible: true
modifier: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_31e44ac5_1868_42ff_a8f6_2cc520401ea1
is: P16930
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2184
constant: false
boundary condition: true
name: FAH
has only substance units: false
type: Species

metaR r1164
type: Reaction
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is: SBO:0000176
name: EC:2.3.1.26
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
is described by: ECO:0000000
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110024#_71e275f9_d648_44a9_82d7_aa70c60f1a12
is: SBO:0000252
boundary condition: true
is: P53396
is encoded by: hsa:47
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
name: ACLY
constant: false

metaR RE3269C
is: SBO:0000176
type: Reaction
product: MODEL1310110024#
kinetic law: MODEL1310110024#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (8897.1) or (8897.3) or (8897.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:Recin 1 had irreversible version - PI35P3P - GPR from PI35P3P was added - May 2011 IT
fast: false
modifier: MODEL1310110024#
name: RE3269
is version of: http://identifiers.org/ec-code/3.1.3.48

metaM prostgf2 e
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
name: prostaglandin F2alpha(1-)
is: SBO:0000247
is: CHEBI:57404
constant: false
is: HMDB01139

metaM 3oddcoa m
name: 3-Oxododecanoyl-CoA
type: Species
initial concentration: 1.0
is: HMDB03937
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:27868
constant: false
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263

http://identifiers.org/biomodels.db/MODEL1310110024#_56c82318_b1b4_4b10_8f03_85d337446125
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10678
initial concentration: NaN
name: B3GNT2
constant: false
boundary condition: true
initial amount: NaN

metaR DOLPGT1 Ler
is version of: http://identifiers.org/ec-code/2.4.1.267
notes: GENE_ASSOCIATION: (29929.1) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
is: SBO:0000176
type: Reaction
product: MODEL1310110024#
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (liver)
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
is described by: ECO:0000000
reactant: MODEL1310110024#
fast: false
reversible: false

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

metaR r0423
modifier: MODEL1310110024#
reactant: MODEL1310110024#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
kinetic law: MODEL1310110024#
fast: false
reversible: true
product: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_0a527120_9a96_4146_831e_6720bd13f220
name: MVD
boundary condition: true
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4597
is: P53602

http://identifiers.org/biomodels.db/MODEL1310110024#_3d6e9cef_1a6e_47a8_9ffe_cf82e891a628
is encoded by: hsa:23632
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
name: CA14
boundary condition: true
is: A8K3J4
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_bc563e09_50d3_414a_9022_3dbf7b62c5e2
is: SBO:0000252
is encoded by: hsa:10558
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
name: SPTLC1
type: Species
is: O15269

metaR MAL Ltx
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110024#
fast: false
is: SBO:0000185
product: MODEL1310110024#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
reactant: MODEL1310110024#
name: Transport reaction for malate

metaM fuc L l
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
is: HMDB00174
is: CHEBI:18287
name: L-fucose
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110024#_478529db_b17f_49e2_ae7e_96cb3e6b8dbe
type: Species
initial amount: NaN
is encoded by: hsa:23600
initial concentration: NaN
boundary condition: true
name: AMACR
is: SBO:0000252
is: Q3KT79
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_6fb420b7_33cf_43d7_8838_ce74b2ebaccc
has only substance units: false
is encoded by: hsa:55825
boundary condition: true
initial concentration: NaN
constant: false
is: Q9BY49
is: SBO:0000252
type: Species
initial amount: NaN
name: PECR

metaM tyr L c
has only substance units: false
is: CHEBI:17895
is: SBO:0000247
is: HMDB00158
constant: false
initial amount: NaN
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
type: Species
boundary condition: false
initial concentration: 1.0
name: L-tyrosine

metaR CHLP
reversible: false
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (162466.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.15 Confidence Level: 0 AUTHORS: PMID:15175005 NOTES:no high energy phosphate compounds found associated w/ rxn NJ
is: SBO:0000176
product: MODEL1310110024#
is described by: ECO:0000000
reactant: MODEL1310110024#
fast: false
type: Reaction
name: choline phosphate phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.75

metaM hdd2coa x
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h16-17,24-26,30-32,36,47-48H,4-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b17-16+/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
initial concentration: 1.0
is: CHEBI:61526
is: HMDB03945
constant: false
name: (E)-hexadec-2-enoyl-CoA(4-)

metaR G14T10g
product: MODEL1310110024#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8703.1) or (8704.2) or (8704.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
kinetic law: MODEL1310110024#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
reactant: MODEL1310110024#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110024#
fast: false

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_0e6aec19_2e05_4256_9ba3_4e54c23c6aec
is: P22303
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:43
name: ACHE
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110024#_1b5af59d_0eb0_4d08_b352_8192343b69d1
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:5207
name: PFKFB1
has only substance units: false
is: P16118
initial amount: NaN
boundary condition: true

metaR DPMVDx
notes: GENE_ASSOCIATION: (4597.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.1.33 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
modifier: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.33
product: MODEL1310110024#
reactant: MODEL1310110024#
reversible: false
kinetic law: MODEL1310110024#
type: Reaction
name: diphosphomevalonate decarboxylase

metaM HC00718 c
has only substance units: false
name: N-methylethanolaminium phosphate(1-)
initial concentration: 1.0
constant: false
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
boundary condition: false
is: SBO:0000247
is: CHEBI:57781
initial amount: NaN
type: Species

metaM prostgf2 c
is: SBO:0000247
type: Species
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
name: prostaglandin F2alpha(1-)
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:57404
is: HMDB01139

http://identifiers.org/biomodels.db/MODEL1310110024#_8767a2fc_276a_4387_a4ec_31a0f8726663
type: Species
initial concentration: NaN
is encoded by: hsa:6120
is: Q53TV9
has only substance units: false
is: SBO:0000252
boundary condition: true
name: RPE
constant: false
initial amount: NaN

metaR IDOURtly
is: SBO:0000185
reactant: MODEL1310110024#
name: iduronate transport into lysososme
product: MODEL1310110024#
is described by: ECO:0000269
reversible: true
fast: false
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261,PMID:9852127 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 (for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD added IdoA reaction - NCD
type: Reaction
modifier: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_ddef644a_eacc_4458_9b1d_8b81d5865dfb
has only substance units: false
type: Species
is: SBO:0000252
constant: false
is: Q9Y6L6
boundary condition: true
is encoded by: hsa:10599
name: SLCO1B1
initial concentration: NaN
initial amount: NaN

metaR r0539
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.1.1.34
type: Reaction
product: MODEL1310110024#
reversible: true
name: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19
modifier: MODEL1310110024#
fast: false

metaM ksi deg1 e
is: CHEBI:17268
constant: false
is: HMDB00211
name: keratan sulfate I, degradation product 1
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaR FCOAH
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:11341778,PMID:11591435 NOTES:Note - formcoa formula is uncharged - the correct is FACOAH2 w/ forcoa NJ
reversible: false
fast: false
is: SBO:0000176
name: formyl coa hydrolase
kinetic law: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
reactant: MODEL1310110024#

metaM tag hs c
has only substance units: false
name: triglyceride
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
boundary condition: false
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
is: SBO:0000247
is: CHEBI:17855

http://identifiers.org/biomodels.db/MODEL1310110024#_bf68ff60_8b96_48a9_b281_0c2d02876681
type: Species
constant: false
is encoded by: hsa:9162
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: DGKI
is: O75912

metaR EX HC01361 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Dihydroneopterin
type: Reaction

metaM cs e deg7 l
is: CHEBI:15936
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 7
is: SBO:0000247
notes: FORMULA: C23H35O27S2 CHARGE: -3
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_06a8ab0a_4f78_4d06_9f27_8fc59807f7f4
initial concentration: NaN
is: Q9Y2P5
boundary condition: true
type: Species
name: SLC27A5
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:10998
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_6565a472_ef85_41d2_85b3_69f4a541cb7a
initial amount: NaN
constant: false
name: NDUFA13
is: SBO:0000252
is: Q9P0J0
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:51079

http://identifiers.org/biomodels.db/MODEL1310110024#_aff8b58b_1c0f_4e4b_a2ee_57e9c68575a6
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2110
is: Q16134
name: ETFDH
type: Species
boundary condition: true
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_dbec4949_e99e_4698_a25a_b07001abbb08
has part: B2RAU6
is: SBO:0000297
constant: false
initial concentration: NaN
initial amount: NaN
has part: P57054
is encoded by: hsa:5277
is encoded by: hsa:51227
is encoded by: hsa:5279
is encoded by: hsa:9091
boundary condition: true
type: Species
has only substance units: false
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ

metaR FAOXC16OHC16r
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(C16-->w-OHC16)er
type: Reaction

metaR CRNrtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: added during gap filling. NOTES:added during gap filling.
kinetic law: MODEL1310110024#
name: reversible transport of L-Carnitine in peroxisome
reversible: true
type: Reaction
reactant: MODEL1310110024#
product: MODEL1310110024#
is described by: ECO:0000134
fast: false
is: SBO:0000185

metaR EX adp
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: adp exchange
type: Reaction

metaM glucys c
is: CHEBI:58173
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01049
has only substance units: false
boundary condition: false
is: C00669
name: gamma-L-Glutamyl-L-cysteine
notes: FORMULA: C8H13N2O5S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00487 EHMN_ABBREVIATION: C00669
is: SBO:0000247

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

metaR KSIt
reactant: MODEL1310110024#
fast: false
reversible: false
product: MODEL1310110024#
name: keratan sulfate I transport, golgi to extracellular
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110024#

metaM CE2432 m
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
is: CHEBI:57795
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110024#_d6a18424_397f_45b3_88fb_92810bf46250
has only substance units: false
constant: false
is: P37268
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2222
name: FDFT1
initial concentration: NaN

metaR r1167
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
reversible: false
type: Reaction
product: MODEL1310110024#
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
is: SBO:0000176
name: EC:2.3.1.26
is described by: ECO:0000000

metaR CYSALANaEx
is: SBO:0000185
modifier: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110024#
name: L-alanine/L-cysteine Na-dependent exchange (Cys-L in)
kinetic law: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaM ocde9ecoa x
is: http://identifiers.org/pubchem.compound/5280355
is: SBO:0000247
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: 9-octadecenoylcoa
notes: FORMULA: C39H64N7O17P3S CHARGE: -4

metaR C181CPT2
kinetic law: MODEL1310110024#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110024#
reversible: false
product: MODEL1310110024#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
name: transport of Octadecenoyl-CoA into mitochondrial matrix
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TDV
modifier: MODEL1310110024#

metaM g2m8mpdol U r
constant: false
is: CHEBI:59093
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C1845H3040N20O720P20 CHARGE: -20
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110024#_90696e2f_129d_49e7_bbb0_420b0551e803
boundary condition: true
name: FECH
is: P22830
is: SBO:0000252
type: Species
is encoded by: hsa:2235
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_37cb3a10_2e2d_4703_aa94_3910d8b35c10
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
name: ATP1A2
is encoded by: hsa:477
constant: false
is: P50993

metaM sphings c
constant: false
name: sphingosine(1+)
is: HMDB00252
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:57756
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319

metaM fum c
constant: false
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:29806
name: Fumarate
initial amount: NaN
boundary condition: false
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
is: C00122
initial concentration: 1.0
is: HMDB00134

http://identifiers.org/biomodels.db/MODEL1310110024#_be971f64_07fa_43f4_bf3e_7acc23906c95
boundary condition: true
is: P18405
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: SRD5A1
constant: false
is encoded by: hsa:6715
type: Species
has only substance units: false

metaM icit c
is: SBO:0000247
constant: false
is: C00311
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
name: Isocitrate
is: CHEBI:16087
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
is: HMDB00193

http://identifiers.org/biomodels.db/MODEL1310110024#_37b5648a_987e_4e28_890a_55e348a7dedb
is encoded by: hsa:4700
initial concentration: NaN
initial amount: NaN
name: NDUFA6
type: Species
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
is: P56556

http://identifiers.org/biomodels.db/MODEL1310110024#_3c6f7356_51a1_4798_9be6_33b574386485
type: Species
constant: false
is encoded by: hsa:AI440329
boundary condition: true
name: _AI440329_1_r
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR ENGASEly
reactant: MODEL1310110024#
name: endo-beta-N-acetylglucosaminidase, lysosomal
is: SBO:0000176
reversible: false
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110024#

metaR PYRt2p
name: pyruvate peroxisomal transport via proton symport
kinetic law: MODEL1310110024#
is described by: ECO:0000269
is: SBO:0000185
reversible: true
reactant: MODEL1310110024#
fast: false
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: D-alanine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12705896,PMID:12739169,PMID:9786900 NOTES:NCD
type: Reaction
modifier: MODEL1310110024#

metaM sebcoa x
initial amount: NaN
name: sebacoylcoa
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/16019966
has only substance units: false
type: Species
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
initial concentration: 1.0
constant: false
boundary condition: false

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

metaM tdcoa m
name: Tetradecanoyl-CoA (n-C14:0CoA)
type: Species
is: HMDB01521
boundary condition: false
is: CHEBI:57385
is: C02593
is: SBO:0000247
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0

metaM ksii core4 deg4 l
type: Species
is: HMDB01354
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:57455
notes: FORMULA: C66H108N6O48SX CHARGE: -1
has only substance units: false
constant: false
name: keratan sulfate II (core 4-linked), degradation product 4

metaM HC01401 m
type: Species
name: (S)-3-Hydroxydodecanoyl-CoA
has only substance units: false
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:27668

metaM tag hs e
name: triglyceride
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
is: CHEBI:17855
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110024#_0648640f_dc46_410a_8c87_25831c179dde
initial amount: NaN
name: AMY1A
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:276
boundary condition: true
constant: false
is: Q6NSB3
type: Species

metaR NMNtn
reactant: MODEL1310110024#
reversible: true
name: NMN transport, nuclear trhough pore
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110024#
kinetic law: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_98f1f658_0e8a_43b2_aeb5_a8b6c21eafe2
constant: false
is: Q549M5
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:4718
type: Species
initial concentration: NaN
name: NDUFC2

http://identifiers.org/biomodels.db/MODEL1310110024#_80be492d_b5fe_4d79_9465_4e36859b3f35
type: Species
boundary condition: true
has only substance units: false
name: OCRL
is: SBO:0000252
is encoded by: hsa:4952
initial amount: NaN
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_af16fc1e_a0fb_482c_84a5_a0eed8ccf3c3
name: ALDH1B1
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:219
is: P30837
initial amount: NaN
type: Species
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_76fd7ab7_2246_4b29_b6db_74d79885fe65
is: P36269
initial amount: NaN
constant: false
is: SBO:0000252
name: GGT5
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:2687
has only substance units: false

metaM hdcecrn c
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB00222
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m1/s1
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
name: Hexadecenoyl carnitine

metaR ICDHyrm
kinetic law: MODEL1310110024#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
product: MODEL1310110024#
type: Reaction
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.1.1.42
is: SBO:0000176
name: Isocitrate dehydrogenase (NADP+)
reactant: MODEL1310110024#
is described by: ECO:0000269

metaM 5adtststerone e
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
type: Species
is: HMDB02961
boundary condition: false
is: CHEBI:16330
name: 17beta-hydroxy-5alpha-androstan-3-one

metaR FAOXC101C8x
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C8:0)x
type: Reaction

metaM Rtotal2coa c
boundary condition: false
is: HMDB00095
constant: false
name: R total 2 coenzyme A
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4
is: CHEBI:60377
initial concentration: 1.0
is: C00055
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_a847be81_30cf_49e4_abc2_9d79c4e7e1e8
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: B3KTV4
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:122622
type: Species
name: ADSSL1

http://identifiers.org/biomodels.db/MODEL1310110024#_3acb211f_2511_4188_89da_d8fcc1e33b4f
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
constant: false
name: _H53099_1_m
is encoded by: hsa:H53099
initial concentration: NaN
is: SBO:0000252

metaM CE5160 r
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-26,28,32-34,38,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5160
type: Species
name: 3-oxo-cis-9-octadecenoyl-CoA
is: CHEBI:57923
initial concentration: 1.0

metaR RE3000M
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is: SBO:0000176
name: RE3000
fast: false
product: MODEL1310110024#
kinetic law: MODEL1310110024#
type: Reaction

metaM idour e
constant: false
is: HMDB02704
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:21338
type: Species
has only substance units: false
name: L-iduronate
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_f99d20df_b1a7_4ac4_ba7c_7717c5bc6aa3
is: SBO:0000252
initial concentration: NaN
is: Q9BRC7
name: PLCD4
type: Species
has only substance units: false
is encoded by: hsa:84812
constant: false
boundary condition: true
initial amount: NaN

metaM 25aics c
initial amount: NaN
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
has only substance units: false
is: CHEBI:58443
constant: false
initial concentration: 1.0
is: HMDB00797
type: Species
is: SBO:0000247
notes: FORMULA: C13H15N4O12P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01356 EHMN_ABBREVIATION: C04823
is: C04823
boundary condition: false

metaM ahdt e
initial amount: NaN
is: SBO:0000247
is: CHEBI:58462
notes: FORMULA: C9H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C9H16N5O13P3/c10-9-13-7-5(8(17)14-9)12-3(1-11-7)6(16)4(15)2-25-29(21,22)27-30(23,24)26-28(18,19)20/h4,6,15-16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H4,10,11,13,14,17)/p-4/t4-,6+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01367 EHMN_ABBREVIATION: C04895
constant: false
boundary condition: false
type: Species
has only substance units: false
name: 7,8-dihydroneopterin 3'-triphosphate(4-)
initial concentration: 1.0
is: HMDB00980

http://identifiers.org/biomodels.db/MODEL1310110024#_41adcade_aea9_4190_b73a_3c835219c23b
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: P40926
boundary condition: true
type: Species
constant: false
name: MDH2
is encoded by: hsa:4191
has only substance units: false

metaR r2313
type: Reaction
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110024#
product: MODEL1310110024#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
fast: false
is described by: ECO:0000000

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_0e710a8c_e31c_4867_b044_2194da137290
constant: false
initial amount: NaN
is: Q9BY32
initial concentration: NaN
name: ITPA
is encoded by: hsa:3704
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252

metaM ksi pre29 g
name: keratan sulfate I biosynthesis, precursor 29
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:28067
notes: FORMULA: C213H340N15O179S9X CHARGE: -10
is: SBO:0000247

metaR PRFGS
product: MODEL1310110024#
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (5198.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
name: phosphoribosylformylglycinamidine synthase
is described by: ECO:0000269
reactant: MODEL1310110024#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.5.3
kinetic law: MODEL1310110024#
reversible: false
type: Reaction

metaM acngalgbside hs g
initial concentration: 1.0
constant: false
notes: FORMULA: C61H105N3O35FULLRCO CHARGE: -1
name: sialyl galactosylgloboside
has only substance units: false
initial amount: NaN
is: HMDB03406
boundary condition: false
is: SBO:0000247
is: CHEBI:16523
type: Species

metaR AG13T3g
notes: GENE_ASSOCIATION: (10331.1) or (11041.1) or (374907.2) or (10678.1) or (79369.1) or (374907.1) or (10678.2) or (93010.1) or (146712.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false
kinetic law: MODEL1310110024#
product: MODEL1310110024#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110024#
is: SBO:0000176
fast: false
reactant: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_e79e2436_a2d4_42fb_9c1c_1554049979c5
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: Q9HCQ5
has only substance units: false
is encoded by: hsa:50614
initial concentration: NaN
name: GALNT9
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_f3955255_42f6_41e1_bf12_076882dc1b48
boundary condition: true
name: ENTPD2
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: Q5SPY7
type: Species
is encoded by: hsa:954

metaM udpacgal c
name: UDP-N-acetyl-D-galactosamine(2-)
is: SBO:0000247
boundary condition: false
is: CHEBI:57847
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB00304
constant: false
has only substance units: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203

metaR PHEMEtm
is: SBO:0000185
reversible: true
name: Heme transport to cytosol
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV changed name to"tm" to indicate mitochondrial transport NCD
is described by: ECO:0000000
product: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false
reactant: MODEL1310110024#

metaM 3oddcoa x
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: 3-Oxododecanoyl-CoA
is: HMDB03937
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:27868

http://identifiers.org/biomodels.db/MODEL1310110024#_2257e920_b445_457b_967d_4cb33015a15d
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:1103
has only substance units: false
name: CHAT
is: SBO:0000252
constant: false
is: D3DX95

metaM c226crn m
initial amount: NaN
has only substance units: false
is: HMDB06510
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/127055
is: SBO:0000247
constant: false
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
type: Species
name: cervonyl carnitine
boundary condition: false

metaM 5adtststerone c
type: Species
is: HMDB02961
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:16330
name: 17beta-hydroxy-5alpha-androstan-3-one
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917

metaR ITCOALm
product: MODEL1310110024#
fast: false
type: Reaction
is described by: ECO:0000212
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110024#
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
is version of: http://identifiers.org/ec-code/6.2.1.5
is version of: http://identifiers.org/ec-code/6.2.1.4
reversible: true
modifier: MODEL1310110024#

metaM dnad c
is: HMDB01179
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
name: Deamino-NAD+
constant: false
is: C00857
is: CHEBI:18304
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR r2526
is: SBO:0000185
product: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110024#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is described by: ECO:0000000

metaR LEUKTRD4t
name: leukotriene D4 transport
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110024#
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110024#
reversible: true

metaM 10fthf7glu e
initial amount: NaN
boundary condition: false
is: HMDB00224
notes: FORMULA: C50H57N13O25 CHARGE: -8
has only substance units: false
type: Species
is: SBO:0000247
name: 10-formyltetrahydrofolate-[Glu](7)
initial concentration: 1.0
is: CHEBI:58190
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_769aac26_f6bd_4d23_8b75_1b8481778a14
type: Species
is: P21953
initial amount: NaN
is encoded by: hsa:594
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
name: BCKDHB
constant: false

metaR r2312
reversible: true
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is: SBO:0000185
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
fast: false

metaR PNTOte
is described by: ECO:0000134
kinetic law: MODEL1310110024#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110024#
type: Reaction
fast: false
product: MODEL1310110024#
name: Transport of (R)-Pantothenate
is: SBO:0000185

metaR FAOXC103C102m
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)m
type: Reaction

metaR OCTAt
is described by: ECO:0000000
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:JLR
product: MODEL1310110024#
name: Octanoate transport via diffusion
fast: false
reactant: MODEL1310110024#
reversible: true
type: Reaction
is: SBO:0000185

metaR ARACHDtr
is: SBO:0000185
is described by: ECO:0000000
name: intracellular transport
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
product: MODEL1310110024#
fast: false
type: Reaction
kinetic law: MODEL1310110024#
reversible: true

metaR UDPtl
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ
name: udp intracellular transport
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110024#
is: SBO:0000185
fast: false
reactant: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_4db798e4_8c18_4403_84cf_1ae01340ca47
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:53354
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: PANK1
boundary condition: true

metaR URAt
type: Reaction
name: uracil transport via facilated diffusion
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
product: MODEL1310110024#
modifier: MODEL1310110024#
is described by: ECO:0000269
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110024#
fast: false

metaM fad r
boundary condition: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
constant: false
is: SBO:0000247
is: CHEBI:16238
is: HMDB01248
name: Flavin adenine dinucleotide oxidized
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_d204dbe9_8cff_4981_9a38_a895a20a72aa
name: AK2
type: Species
is: SBO:0000252
is encoded by: hsa:204
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false

metaR PROD2m
is: SBO:0000176
name: Proline dehydrogenase (m)
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR SAB m
fast: false
product: MODEL1310110024#
reversible: false
type: Reaction
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.5.99.8
is described by: ECO:0000254

metaM 3otdcoa m
initial concentration: 1.0
has only substance units: false
is: CHEBI:28726
boundary condition: false
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-22,24,28-30,34,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t24-,28-,29-,30+,34-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01400 EHMN_ABBREVIATION: C05261
constant: false
name: 3-Oxotetradecanoyl-CoA
is: HMDB03935
initial amount: NaN
is: SBO:0000247
type: Species

metaR r2315
is: SBO:0000185
fast: false
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110024#
type: Reaction
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110024#
reversible: true

metaM c4dc x
is: C02862
notes: FORMULA: C11H18NO6 CHARGE: -1
boundary condition: false
name: succinyl carnitine
is: SBO:0000247
is: HMDB02013
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/213144
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_e3a8c36b_d9d0_4d92_a85b_3bf404e4a5ed
is: SBO:0000252
has only substance units: false
name: PIK3R3
is encoded by: hsa:8503
boundary condition: true
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is: Q92569

metaM btamp m
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:3110
constant: false
type: Species
name: Biotinyl-5'-AMP
is: HMDB04220
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921

metaM idour c
initial amount: NaN
constant: false
boundary condition: false
is: HMDB02704
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
name: L-iduronate
is: CHEBI:21338
is: SBO:0000247
type: Species

metaR biomass reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110024#
reversible: false
product: MODEL1310110024#
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000134
name: Generic human biomass reaction
kinetic law: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_28632925_3104_4bf7_a5cf_dde2b5821bb9
has only substance units: false
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
name: NSDHL
is encoded by: hsa:50814
is: SBO:0000252
boundary condition: true
is: Q15738

metaR MANtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: mannose efflux from Golgi apparatus
kinetic law: MODEL1310110024#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110024#
is described by: ECO:0000000
fast: false
reversible: false
product: MODEL1310110024#

metaM CE5786 e
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
constant: false
name: kinetensin
initial amount: NaN
boundary condition: false
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
is: CHEBI:27485
is: HMDB02710

http://identifiers.org/biomodels.db/MODEL1310110024#_200a8539_0850_4ca6_b618_cccb1cf6c71b
is encoded by: hsa:3073
is: P06865
type: Species
has only substance units: false
initial concentration: NaN
name: HEXA
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false

metaR DAGt
name: diacylglycerol transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.1.107 Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
product: MODEL1310110024#
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110024#_b4c8f7cc_d975_4b59_b877_a1faac925dc6
name: PIK3CD:PIK3R1
constant: false
initial concentration: NaN
is: SBO:0000297
has only substance units: false
initial amount: NaN
is encoded by: hsa:5295
type: Species
has part: E7EX19
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110024#_f24cc85d_d1dd_48c3_9ab1_9796f96c52b6
initial concentration: NaN
name: TST
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is: Q16762
constant: false
is: SBO:0000252
is encoded by: hsa:7263

metaM udpacgal g
name: UDP-N-acetyl-D-galactosamine(2-)
is: HMDB00304
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: SBO:0000247
boundary condition: false
is: CHEBI:57847

metaR PYRt2m
reversible: true
is: SBO:0000185
fast: false
is described by: ECO:0000000
product: MODEL1310110024#
modifier: MODEL1310110024#
type: Reaction
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD
name: pyruvate mitochondrial transport via proton symport

metaR ACGALK
is described by: ECO:0000000
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
name: N-acetylgalactosamine kinase
type: Reaction
product: MODEL1310110024#

metaM fuc L c
is: CHEBI:18287
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
name: L-fucose
is: SBO:0000247
boundary condition: false
is: HMDB00174
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
has only substance units: false

metaR CITtam
product: MODEL1310110024#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000269
name: citrate transport, mitochondrial
fast: false
modifier: MODEL1310110024#
type: Reaction
reversible: true

metaM gumgchol e
has only substance units: false
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/102468
is: C02155
is: SBO:0000247
name: guar gum-glycocholate complex
notes: FORMULA: C2760026H5060043NO2530006 CHARGE: 0
constant: false
initial concentration: 1.0
is: HMDB00759
boundary condition: false

metaR r2314
reversible: true
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110024#
product: MODEL1310110024#
is: SBO:0000185
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
fast: false

metaR HESTRATRIOLtr
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism, hydroxylated (inactivated) estrogen derivative needs to be transported out of the cell NJ
fast: false
is: SBO:0000185
name: hydroxylated estrogen derivative transport
product: MODEL1310110024#
kinetic law: MODEL1310110024#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110024#

metaM 5mthf c
notes: FORMULA: C20H24N7O6 CHARGE: -1
name: 5-Methyltetrahydrofolate
is: SBO:0000247
is: HMDB01396
is: C00440
constant: false
is: CHEBI:3729
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaR r0531
product: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:9923963 NOTES:
modifier: MODEL1310110024#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.34
name: dUTP:cytidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
reactant: MODEL1310110024#
type: Reaction

metaR RE3624M
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110024#
product: MODEL1310110024#
is described by: ECO:0000000
reversible: false
name: RE3624
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:

metaM HC00229 e
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
initial concentration: 1.0
is: CHEBI:28189
name: Isomaltose
has only substance units: false
type: Species

metaR COQ7m
fast: false
reactant: MODEL1310110024#
product: MODEL1310110024#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (10229.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_1.14.13.- IT
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
reversible: false
is described by: ECO:0000269
name: Ubiquinone biosynthesis COQ7

metaR RE1534M
reversible: true
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
kinetic law: MODEL1310110024#
fast: false
product: MODEL1310110024#
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
name: RE1534
modifier: MODEL1310110024#

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

metaR EX his L LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-histidine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_1d3a7c1c_e500_4bef_8e0e_6625b5f70a25
has only substance units: false
name: OGDHL
is encoded by: hsa:55753
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is: Q9ULD0

metaR SERGLNexR
fast: false
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110024#
type: Reaction
modifier: MODEL1310110024#
reversible: true
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
is described by: ECO:0000304
is: SBO:0000185
name: L-Serine/Glutamine reversible exchange

http://identifiers.org/biomodels.db/MODEL1310110024#_ae75c22a_3256_4bc4_a456_b5303e4c0545
constant: false
name: SULT1A3
boundary condition: true
is encoded by: hsa:6818
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_2dee972c_4c29_40eb_b00e_40330d0e16ce
constant: false
has only substance units: false
is encoded by: hsa:7296
name: TXNRD1
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110024#_555bce99_c734_44a7_8188_aae35dca877b
initial amount: NaN
name: SLC5A11
initial concentration: NaN
is: Q8WWX8
is encoded by: hsa:115584
type: Species
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252

metaR r0426
is: SBO:0000176
reactant: MODEL1310110024#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.34
type: Reaction
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
product: MODEL1310110024#
reversible: true
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false

metaR RE2269E
is version of: http://identifiers.org/ec-code/3.4.21.39
is: SBO:0000176
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000000
kinetic law: MODEL1310110024#
type: Reaction
fast: false
name: RE2269
modifier: MODEL1310110024#
reversible: true
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:

metaR PAPtg
name: adenosine 3',5'-bisphosphate Golgi transport
is: SBO:0000185
kinetic law: MODEL1310110024#
fast: false
product: MODEL1310110024#
reactant: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: false
is described by: ECO:0000000

metaM dmnoncoa x
is: SBO:0000247
initial concentration: 1.0
type: Species
name: 4,8 dimethylnonanoyl-CoA
initial amount: NaN
constant: false
is: HMDB11604
has only substance units: false
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
boundary condition: false

metaM fuc L e
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
name: L-fucose
is: SBO:0000247
is: HMDB00174
is: CHEBI:18287
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_9a74959d_8d46_4bbf_9994_36c8defe6fb3
name: HADHA
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:3030
has only substance units: false
initial concentration: NaN
is: E9KL44
constant: false

metaR CORE2GTg
reversible: false
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
is described by: ECO:0000000
product: MODEL1310110024#
fast: false
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
type: Reaction
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.4.1.102
notes: GENE_ASSOCIATION: (9245.1) or (2650.1) or (51301.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:10753916,PMID:9915862 NOTES:NCD

metaR SIAASEly
product: MODEL1310110024#
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110024#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
fast: false
name: sialidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110024#

metaR CITRtm
fast: false
modifier: MODEL1310110024#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110024#
reactant: MODEL1310110024#
reversible: true
name: citrulline mitochondrial transport via proton antiport
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
kinetic law: MODEL1310110024#
is: SBO:0000185

metaM HC01401 x
boundary condition: false
is: CHEBI:27668
initial concentration: 1.0
constant: false
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
name: (S)-3-Hydroxydodecanoyl-CoA

metaR LEUKTRF4t
reversible: true
is: SBO:0000185
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
type: Reaction
name: leukotriene F4 transport
product: MODEL1310110024#
fast: false
kinetic law: MODEL1310110024#

metaM fum m
has only substance units: false
initial amount: NaN
is: CHEBI:29806
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: Fumarate
is: HMDB00134
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
constant: false
type: Species
is: C00122

metaR FAOXC164C163x
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)x
type: Reaction

metaM tyr L e
initial concentration: 1.0
constant: false
is: HMDB00158
is: SBO:0000247
boundary condition: false
type: Species
name: L-tyrosine
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
has only substance units: false
is: CHEBI:17895
initial amount: NaN

metaM 5mthf e
notes: FORMULA: C20H24N7O6 CHARGE: -1
is: C00440
is: CHEBI:3729
initial concentration: 1.0
boundary condition: false
is: HMDB01396
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: 5-Methyltetrahydrofolate
constant: false
type: Species

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_e05e9d1c_7399_49c2_bd99_096863d74b7e
is: SBO:0000252
boundary condition: true
constant: false
name: SULT1A1
is encoded by: hsa:6817
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species

metaR r2525
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110024#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reactant: MODEL1310110024#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110024#
fast: false
type: Reaction

metaM ksi deg1 l
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
name: keratan sulfate I, degradation product 1
initial amount: NaN
is: HMDB00174
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
is: SBO:0000247
is: CHEBI:18287
type: Species

metaM retn r
is: CHEBI:35291
name: all-trans-retinoate
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB01852
initial amount: NaN
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_cc082158_4cd5_4365_9aaf_a4973092c149
initial amount: NaN
constant: false
is: Q16222
initial concentration: NaN
name: UAP1
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:6675

metaM 4mop m
constant: false
is: SBO:0000247
name: 4-methyl-2-oxopentanoate
has only substance units: false
boundary condition: false
is: CHEBI:17865
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
initial concentration: 1.0
type: Species
is: HMDB00695
initial amount: NaN

metaR GASNASE2ly
name: glycosylasparaginase, lysosomal
reversible: false
fast: false
product: MODEL1310110024#
modifier: MODEL1310110024#
is: SBO:0000176
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/3.5.1.26
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_a51a0777_2f3a_40c1_91d1_b797fa750209
is: SBO:0000252
is encoded by: hsa:30
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: Q96CA6
name: ACAA1
boundary condition: true
type: Species

metaR NICRNS
name: NICRNS
fast: false
reactant: MODEL1310110024#
is: SBO:0000176
kinetic law: MODEL1310110024#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:no gene or enzyme name known (in kegg) but reaction has to take place. IT
product: MODEL1310110024#
type: Reaction
reversible: false

metaR r2311
product: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110024#
reversible: true
is: SBO:0000185
fast: false
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_ee0ff1d5_b4dd_41eb_b6f1_54f7cbd39c22
is encoded by: hsa:10449
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
is: P42765
type: Species
name: ACAA2
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_136099bf_f571_49fd_9e74_ef87dcc678d8
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:376497
boundary condition: true
name: SLC27A1
is: SBO:0000252
type: Species
constant: false
is: Q6PCB7

metaR GLNCYSNaEx
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
reversible: false
name: L-cysteine/L-glutamine Na-dependent exchange (Gln-L in)
is described by: ECO:0000269
product: MODEL1310110024#
reactant: MODEL1310110024#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110024#_7d8753e0_2cef_49f2_9b63_4b0a5932e080
constant: false
name: _AI222095_1_e
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:AI222095
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR FAOXC18280m
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
reversible: false
name: Beta oxidation of fatty acid
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110024#
fast: false
modifier: MODEL1310110024#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c18:2, transe -> c8:0 - 5 rounds of beta ox, lose 2 degrees of unsat - only 3 fad oxidized 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ

metaR G14T6g
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110024#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110024#
type: Reaction
is: SBO:0000176
product: MODEL1310110024#
reversible: false
fast: false
is described by: ECO:0000000

metaM g2m8mpdol L r
boundary condition: false
is: SBO:0000247
is: CHEBI:59093
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
type: Species
initial concentration: 1.0
notes: FORMULA: C1900H3128N20O720P20 CHARGE: -20
constant: false
has only substance units: false
initial amount: NaN

metaR SUBEACTD
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberic acid into cytosol (diffusion)
type: Reaction

metaM ksi pre13 g
is: HMDB00175
initial amount: NaN
boundary condition: false
notes: FORMULA: C143H231N10O111S3X CHARGE: -4
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58053
type: Species
is: C00130
has only substance units: false
constant: false
name: keratan sulfate I biosynthesis, precursor 13

http://identifiers.org/biomodels.db/MODEL1310110024#_bee55f51_69bb_4e1b_ad54_89b35ee75d8b
boundary condition: true
type: Species
constant: false
is: SBO:0000252
has only substance units: false
name: HSD3B7
is encoded by: hsa:80270
initial concentration: NaN
initial amount: NaN
is: Q9H2F3

http://identifiers.org/biomodels.db/MODEL1310110024#_9c4c4d45_1845_4a73_b71e_0bc1307e148a
is: SBO:0000252
initial amount: NaN
name: _AA081045_1_c
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AA081045
constant: false

metaR r2310
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110024#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110024#

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

metaR ECOAH9m
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000304
fast: false
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
modifier: MODEL1310110024#
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/4.2.1.17
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
reversible: true
type: Reaction
reactant: MODEL1310110024#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110024#_32449462_659a_4403_b944_dc85453e5fc7
is encoded by: hsa:6581
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: Q5SYN6
name: SLC22A3
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110024#_1f1ab923_d40e_4e03_997a_5dd40fafe7b8
is encoded by: hsa:4698
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: NDUFA5
type: Species
is: Q16718
boundary condition: true
constant: false

metaR r1593
product: MODEL1310110024#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110024#
is described by: ECO:0000000
is: SBO:0000185
fast: false
kinetic law: MODEL1310110024#
reversible: true

metaR LNLNCGCPT1
reversible: false
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
reactant: MODEL1310110024#
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110024#
fast: false
name: carnitine O-palmitoyltransferase
type: Reaction
product: MODEL1310110024#
is: SBO:0000176

metaR GMPtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110024#
reversible: true
reactant: MODEL1310110024#
type: Reaction
name: GMP transport (Golgi)
is: SBO:0000185
fast: false
product: MODEL1310110024#

metaR FATP2t
product: MODEL1310110024#
name: fatty acid electroneutral transport
type: Reaction
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
fast: false
reactant: MODEL1310110024#
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
is: SBO:0000185

metaR FAOXC16DCC14DCx
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16DC-->C14DC)x
type: Reaction

metaR MM7B2g
reversible: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110024#
product: MODEL1310110024#
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.2.1.113
fast: false

http://identifiers.org/biomodels.db/MODEL1310110024#_3ed292db_5400_4fc7_94de_a745ef1b0179
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
is: Q4F7X0
type: Species
is encoded by: hsa:114
name: ADCY8
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110024#_2ed21960_2e0e_421f_8493_5979af536a99
initial concentration: NaN
has only substance units: false
name: COX3
type: Species
constant: false
is encoded by: hsa:4514
is: P00414
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR r2017
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
kinetic law: MODEL1310110024#
product: MODEL1310110024#
modifier: MODEL1310110024#
reversible: false
fast: false
type: Reaction
reactant: MODEL1310110024#
is described by: ECO:0000000

metaR RE0690E
kinetic law: MODEL1310110024#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
is described by: ECO:0000000
fast: false
reversible: false
reactant: MODEL1310110024#
name: RE0690
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.4.3.22
modifier: MODEL1310110024#

metaM mal L x
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
name: (S)-malate(2-)
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
initial amount: NaN
boundary condition: false
is: HMDB00156

metaR r2018
reversible: false
fast: false
modifier: MODEL1310110024#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110024#
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110024#
type: Reaction
is: SBO:0000185

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

metaR r1592
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110024#
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110024#
is described by: ECO:0000000

metaM f1p c
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00662 EHMN_ABBREVIATION: C01094
constant: false
is: CHEBI:18105
is: SBO:0000247
is: C01094
is: HMDB01076
initial amount: NaN
name: D-Fructose 1-phosphate

http://identifiers.org/biomodels.db/MODEL1310110024#_046e4336_fe90_4e72_a7fe_1af633081ad9
has part: P21953
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:593
name: DBT:DLD:BCKDHA:BCKDHB
has only substance units: false
is: SBO:0000297
has part: P11182
has part: B4DP47
is encoded by: hsa:594
initial amount: NaN
constant: false
is encoded by: hsa:1629

metaM ser D e
is: CHEBI:16523
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
name: D-serine
constant: false
is: HMDB03406
boundary condition: false

metaR r0610
reversible: true
is described by: ECO:0000000
name: CTP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11
reactant: MODEL1310110024#
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:131802,PMID:1810251,PMID:193556,PMID:2987258,PMID:6091737 NOTES:
kinetic law: MODEL1310110024#
product: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_f3bde5a3_bfde_4a40_88d4_afebc7d67863
initial amount: NaN
is encoded by: hsa:AU149534
boundary condition: true
name: _AU149534_1_c
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false

metaR DTTPtn
is: SBO:0000185
product: MODEL1310110024#
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false
name: dTTP diffusion in nucleus
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110024#_2d1788d5_0557_46c5_ad50_ef04bb606926
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AI378339
name: _AI378339_1_m
type: Species
is: SBO:0000252
constant: false
boundary condition: true

metaM 3php c
name: 3-phosphonatooxypyruvate(3-)
notes: FORMULA: C3H2O7P CHARGE: -3 INCHI: InChI=1S/C3H5O7P/c4-2(3(5)6)1-10-11(7,8)9/h1H2,(H,5,6)(H2,7,8,9)/p-3 HEPATONET_1.0_ABBREVIATION: HC01082 EHMN_ABBREVIATION: C03232
is: HMDB01024
constant: false
type: Species
is: SBO:0000247
is: CHEBI:18110
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaM prostge1 c
boundary condition: false
is: SBO:0000247
is: HMDB01442
initial amount: NaN
has only substance units: false
is: CHEBI:57397
name: prostaglandin E1(1-)
type: Species
constant: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110024#_a881faea_6883_430c_92e4_ae9e4c3fadb5
has only substance units: false
name: PIK3CA:PIK3R1
is encoded by: hsa:5295
has part: P27986
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110024#_3f2d643b_eda6_457d_80d4_5e4d4cd0d088
initial concentration: NaN
is encoded by: hsa:8879
is: O95470
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
type: Species
name: SGPL1
initial amount: NaN

metaR ACRNtm
is: SBO:0000185
type: Reaction
product: MODEL1310110024#
is described by: ECO:0000269
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:977593 NOTES:NCD
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
reversible: false
name: O-acetylcarnintine transport into mitochondria via diffusion
fast: false

metaM CE4872 m
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:15748
boundary condition: false
type: Species
constant: false
is: HMDB00127
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872

metaR DM taur LPAREN c RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: demand reaction for taurine
type: Reaction

metaR TYMSFt
fast: false
product: MODEL1310110024#
reversible: false
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of tyramine sulfate
name: Tyramine O-sulfate transport (diffusion)
kinetic law: MODEL1310110024#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction

metaM acmanap c
initial concentration: 1.0
name: N-acetyl-D-mannosamine 6-phosphate(2-)
is: SBO:0000247
is: HMDB01121
initial amount: NaN
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-4(11)9-5(2-10)7(13)8(14)6(12)3-18-19(15,16)17/h2,5-8,12-14H,3H2,1H3,(H,9,11)(H2,15,16,17)/p-2 HEPATONET_1.0_ABBREVIATION: HC01257 EHMN_ABBREVIATION: C04257
has only substance units: false
type: Species
constant: false
is: CHEBI:58557
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110024#_06482fac_d488_42c2_a3f3_c118a08117b2
is encoded by: hsa:515
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
name: ATP5F1
is: SBO:0000252
constant: false
initial amount: NaN

metaR r1591
reactant: MODEL1310110024#
fast: false
type: Reaction
kinetic law: MODEL1310110024#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110024#
is: SBO:0000185

metaM dudp n
name: dUDP(3-)
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
is: HMDB01000
is: CHEBI:60471

metaR PSSA1 hs
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (9791.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylcholine as substrate NJ
reversible: true
kinetic law: MODEL1310110024#
product: MODEL1310110024#
is: SBO:0000176
is described by: ECO:0000269
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.8.29
name: Phosphatidylserine synthase homo sapiens
reactant: MODEL1310110024#

metaR S3TASE3ly
product: MODEL1310110024#
fast: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 2 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
name: N-acetylglucosamine-3-sulfatase, lysosomal
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
reversible: true

metaR EX gchola LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycocholate exchange
type: Reaction

metaM nm2masn g
boundary condition: false
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C42H70N3O30X CHARGE: 0
is: C05884
has only substance units: false

metaM strch2 e
constant: false
is: HMDB00122
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:4167
initial concentration: 1.0
name: starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})
boundary condition: false
notes: FORMULA: C18H32O16 CHARGE: 0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_73d5f139_e546_48d8_93df_e888d260b5c6
type: Species
has only substance units: false
name: RDH16
is: O75452
is encoded by: hsa:8608
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR PRO Dtde
product: MODEL1310110024#
fast: false
kinetic law: MODEL1310110024#
type: Reaction
name: D-proline transport, extracellular
is described by: ECO:0000134
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
reactant: MODEL1310110024#

metaR PPItx
kinetic law: MODEL1310110024#
name: Diphosphate transporter, peroxisome
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reactant: MODEL1310110024#
product: MODEL1310110024#
is: SBO:0000185
reversible: true

metaM dhlam m
initial concentration: 1.0
has only substance units: false
is: HMDB00985
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
initial amount: NaN
name: dihydrolipoamide
is: CHEBI:17694
is: SBO:0000247
boundary condition: false
constant: false
type: Species

metaR VLCS2r
reactant: MODEL1310110024#
is: SBO:0000176
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
name: Very-long-chain-fatty-acid-CoA ligase
reversible: false
type: Reaction
modifier: MODEL1310110024#
is described by: ECO:0000304
fast: false
kinetic law: MODEL1310110024#

metaR FAOXC225C226x
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)x
type: Reaction

metaR r1590
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110024#
reversible: true
is: SBO:0000185
reactant: MODEL1310110024#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110024#

metaM 5hoxindoa c
boundary condition: false
name: 5-Hydroxyindoleacetate
initial concentration: 1.0
type: Species
notes: FORMULA: C10H8NO3 CHARGE: -1 INCHI: InChI=1S/C10H9NO3/c12-7-1-2-9-8(4-7)6(5-11-9)3-10(13)14/h1-2,4-5,11-12H,3H2,(H,13,14) HEPATONET_1.0_ABBREVIATION: HC01537 EHMN_ABBREVIATION: C05635
constant: false
has only substance units: false
initial amount: NaN
is: HMDB00763
is: CHEBI:27823
is: SBO:0000247

metaR DCSPTN1t
reversible: true
product: MODEL1310110024#
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110024#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110024#
name: fatty acid transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110024#_6165149f_0f08_4ffd_8a45_dd3aa5cce8a3
is encoded by: hsa:2876
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
name: GPX1

metaR r1928
name: Y+LAT2 Utilized transport
modifier: MODEL1310110024#
fast: false
product: MODEL1310110024#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
reactant: MODEL1310110024#
is: SBO:0000185
kinetic law: MODEL1310110024#

metaM CE5797 e
initial concentration: 1.0
name: neuromedin N
constant: false
has only substance units: false
is: CHEBI:27485
is: SBO:0000247
notes: FORMULA: C32H51N5O7 CHARGE: 0 INCHI: InChI=1/C32H51N5O7/c1-7-19(5)26(33)31(42)37-15-9-10-25(37)29(40)34-23(17-21-11-13-22(38)14-12-21)28(39)36-27(20(6)8-2)30(41)35-24(32(43)44)16-18(3)4/h11-14,18-20,23-27,38H,7-10,15-17,33H2,1-6H3,(H,34,40)(H,35,41)(H,36,39)(H,43,44)/t19-,20-,23+,24+,25-,26-,27-/m1/s1 EHMN_ABBREVIATION: CE5797
initial amount: NaN
is: HMDB02710
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_46f5e94e_cfa4_4fef_867b_7a0136abb943
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
is: E9PB82
is encoded by: hsa:3295
name: HSD17B4
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_9fdce034_e32e_4382_bda8_b4d437a0285c
constant: false
is: SBO:0000252
is encoded by: hsa:2954
type: Species
name: GSTZ1
initial amount: NaN
is: O43708
boundary condition: true
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_a9bda4ea_5c2b_4f30_9896_83de5c608979
initial concentration: NaN
is encoded by: hsa:115
name: ADCY9
constant: false
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: O60503

metaM prostge1 e
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB01442
boundary condition: false
name: prostaglandin E1(1-)
is: CHEBI:57397

metaM q10 m
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB01072
constant: false
initial amount: NaN
name: ubiquinone-10
is: SBO:0000247
is: CHEBI:46245
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
has only substance units: false

metaR FAOXC5C3x
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C5-->C3)m
type: Reaction

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

metaM thmmp c
is: HMDB02666
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:37575
initial amount: NaN
notes: FORMULA: C12H16N4O4PS CHARGE: -1 EHMN_ABBREVIATION: C01081
boundary condition: false
is: SBO:0000247
name: Thiamin monophosphate
is: C01081
has only substance units: false

metaR GLNS
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.1.15
name: glutamine synthetase
product: MODEL1310110024#
reversible: false
modifier: MODEL1310110024#
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000176
fast: false
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_2a06bb52_c018_4233_a58c_42d7a50a1728
has part: B3KUV7
has part: Q9BRB3
is encoded by: hsa:51227
has part: Q92535
is encoded by: hsa:9091
has part: O94777
has part: Q14442
constant: false
initial concentration: NaN
is encoded by: hsa:8818
is: SBO:0000297
is encoded by: hsa:5283
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
initial amount: NaN
boundary condition: true
is encoded by: hsa:5279
type: Species
is encoded by: hsa:5277
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_20704728_8985_4ef3_a974_197f15292e42
type: Species
is encoded by: hsa:1718
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is: Q15392
initial amount: NaN
name: DHCR24

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

metaM hs deg2 l
is: HMDB01352
is: SBO:0000247
name: heparan sulfate, degradation product 2
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:17180
notes: FORMULA: C79H116N5O96S10 CHARGE: -11
has only substance units: false
type: Species

metaM pristcoa x
is: CHEBI:51341
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
constant: false
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
name: pristanoyl coa
initial amount: NaN

metaR KSII CORE2t
is described by: ECO:0000000
product: MODEL1310110024#
reversible: false
kinetic law: MODEL1310110024#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: keratan sulfate II (core2) transport, golgi to extracellular
is: SBO:0000185
reactant: MODEL1310110024#

metaR CYTK8n
reversible: true
product: MODEL1310110024#
name: cytidylate kinase (CMP,dATP),nuclear
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110024#
is: SBO:0000176
fast: false
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
type: Reaction

metaM h2o2 c
is: C00027
name: Hydrogen peroxide
has only substance units: false
constant: false
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
type: Species
is: HMDB03125
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:16240

metaM HC01406 m
is: CHEBI:28264
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267
constant: false
is: SBO:0000247
name: 3-Oxooctanoyl-CoA

metaR DADNK
fast: false
reactant: MODEL1310110024#
name: deoxyadenosine kinase
product: MODEL1310110024#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.76 Confidence Level: 4 AUTHORS: PMID:6317685 NOTES:Deoxyguanosine can also act as acceptor. Possibly identical with EC 2.7.1.74 deoxycytidine kinase.
reversible: false
kinetic law: MODEL1310110024#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110024#_23d72dcd_8345_4c48_8230_21bf1d64fc80
constant: false
is: SBO:0000252
name: PIK3R1
is encoded by: hsa:5295
boundary condition: true
type: Species
is: P27986
has only substance units: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_d8b62042_7b10_4d52_813a_f58263a9c4ee
is: SBO:0000252
has only substance units: false
name: _AL038231_1_c
is encoded by: hsa:AL038231
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
boundary condition: true

metaM cs e deg3 l
constant: false
type: Species
boundary condition: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 3
initial amount: NaN
has only substance units: false
is: CHEBI:15748
is: SBO:0000247
notes: FORMULA: C37H53NO44S4 CHARGE: -6
is: HMDB00127
initial concentration: 1.0

metaR PE HSter
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:
is: SBO:0000185
fast: false
is described by: ECO:0000000
reactant: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
kinetic law: MODEL1310110024#
name: phosphatidylethanolamine scramblase

metaM f6p c
type: Species
is: SBO:0000247
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/3385
is: CHEBI:57579
initial amount: NaN
boundary condition: false
is: C00085
is: HMDB00124
name: D-Fructose 6-phosphate
initial concentration: 1.0

metaM CE1936 e
boundary condition: false
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C10H22N2O2 CHARGE: 2 INCHI: InChI=1/C10H20N2O2/c13-9-3-7-11-5-1-2-6-12-8-4-10-14/h9-12H,1-8H2/p+2 EHMN_ABBREVIATION: CE1936
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:36781
name: spermine dialdehyde

metaR EX 5oxpro LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-oxoprolinate
type: Reaction

metaM hdcoa m
has only substance units: false
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
is: HMDB06532
boundary condition: false
name: Hexadecenoyl-CoA (n-C16:1CoA)
initial concentration: 1.0
notes: FORMULA: C37H60N7O17P3S CHARGE: -4

metaR PCHOLPm hs
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.1.4.4
type: Reaction
product: MODEL1310110024#
reversible: false
modifier: MODEL1310110024#
is described by: ECO:0000269
is: SBO:0000176
name: choline phosphatase
fast: false

metaR SGALSIDEtg
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
reversible: true
type: Reaction
product: MODEL1310110024#
reactant: MODEL1310110024#
fast: false
is: SBO:0000185
name: sgalside hs intracellular transport
is described by: ECO:0000000

metaM CE0713 m
boundary condition: false
name: 3-oxolinoleoyl-CoA
is: HMDB02329
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
is: CHEBI:30623
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_3167dc4f_6e12_4e00_b407_18ff119c51c1
is: Q9ULC5
is encoded by: hsa:51703
has only substance units: false
initial amount: NaN
name: ACSL5
type: Species
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR r0614
is described by: ECO:0000000
fast: false
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
type: Reaction
is: SBO:0000176
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
kinetic law: MODEL1310110024#
reversible: true
reactant: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_9778f7f0_9156_4f92_9d12_d6ebb240506b
name: GPX6
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:257202
type: Species
has only substance units: false
is: P59796
initial concentration: NaN
initial amount: NaN

metaM Rtotal l
is: CHEBI:52639
initial amount: NaN
type: Species
has only substance units: false
name: R total
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: CO2FULLR CHARGE: -1
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110024#_0f3acb76_a2d9_40ca_9122_3d068590c6dd
has only substance units: false
type: Species
is: P35219
initial amount: NaN
name: CA8
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:767
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_6e3fca63_aaad_44f8_94db_c1f14e652db2
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:LOC374569
has only substance units: false
name: _LOC374569_1_e
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_eb6cb8c8_74ca_47aa_9732_c66591f82426
boundary condition: true
constant: false
name: FUT8
initial amount: NaN
type: Species
is encoded by: hsa:2530
is: A8K8P8
is: SBO:0000252
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_9a4daed9_a950_4c61_bcbb_34a4f4dcdc84
is encoded by: hsa:5169
initial amount: NaN
name: ENPP3
has only substance units: false
constant: false
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: Q308M7

http://identifiers.org/biomodels.db/MODEL1310110024#_4db878e3_66b3_424b_970b_acbffd9cbd93
has part: Q9NY65
is: SBO:0000297
name: EHHADH:ACAA1:ACOX1
is encoded by: hsa:1962
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_aae4cb72_a539_4730_8ef9_a6dd07a2da03
initial concentration: NaN
boundary condition: true
is encoded by: hsa:29968
name: PSAT1
initial amount: NaN
type: Species
has only substance units: false
is: Q9Y617
constant: false
is: SBO:0000252

metaR PCHOLP hs
reversible: false
kinetic law: MODEL1310110024#
type: Reaction
reactant: MODEL1310110024#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.4.4
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:9395408,PMID:9582313 NOTES:NJ
fast: false
modifier: MODEL1310110024#
product: MODEL1310110024#
is: SBO:0000176
name: choline phosphatase

metaR Coqe
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
product: MODEL1310110024#
is described by: ECO:0000134
reversible: true
fast: false
name: Transport of q10
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR C226CPT1
product: MODEL1310110024#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
is: SBO:0000176
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
kinetic law: MODEL1310110024#
type: Reaction
name: carnitine C22:6 transferase

metaR GPIDAer
kinetic law: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
fast: false
is: SBO:0000176
reversible: false
modifier: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (80055.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14734546 NOTES:NCD
name: glycophosphatidylinositol (GPI) deacylase, endoplasmic reticulum

metaM h2o2 e
is: SBO:0000247
is: CHEBI:16240
boundary condition: false
initial amount: NaN
name: hydrogen peroxide
constant: false
initial concentration: 1.0
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
type: Species
is: HMDB03125
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_6a030b2f_719a_4052_8d1f_cde9ffa3f1e0
is encoded by: hsa:4707
name: NDUFB1
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: O75438
type: Species
initial amount: NaN
constant: false

metaR r0611
kinetic law: MODEL1310110024#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.3.1
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:131802,PMID:1810251 NOTES:
product: MODEL1310110024#
name: ITP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11
type: Reaction
is: SBO:0000176
modifier: MODEL1310110024#
reversible: true
reactant: MODEL1310110024#

metaM uri c
is: C00299
is: HMDB00296
is: SBO:0000247
is: CHEBI:16704
name: Uridine
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
constant: false
type: Species
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_eb6f84e5_c739_412c_baae_72ab27c49d5e
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:1468
name: SLC25A10
type: Species
is: Q9UBX3

metaR LEULEUPEPT1tc
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylleucine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaR AKR1D2
type: Reaction
kinetic law: MODEL1310110024#
is: SBO:0000176
product: MODEL1310110024#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.3.1.3
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
reversible: false
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
modifier: MODEL1310110024#

metaR HMGCOASim
is: SBO:0000176
type: Reaction
name: Hydroxymethylglutaryl CoA synthase (ir)
reactant: MODEL1310110024#
reversible: false
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
product: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.3.3.10
is described by: ECO:0000269

metaR P45027A11m
product: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ
type: Reaction
reversible: false
name: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase
is described by: ECO:0000269
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.14.13.15
modifier: MODEL1310110024#

metaR HIStiDF
fast: false
notes: GENE_ASSOCIATION: (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754 NOTES:SAB
product: MODEL1310110024#
reversible: false
kinetic law: MODEL1310110024#
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110024#
reactant: MODEL1310110024#
name: L-histidine transport via diffusion (extracellular to cytosol)

metaR C226CPT2
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
kinetic law: MODEL1310110024#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:TDV
is: SBO:0000176
modifier: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
fast: false
reactant: MODEL1310110024#
name: C226 transport into the mitochondria

http://identifiers.org/biomodels.db/MODEL1310110024#_43f4fec0_021e_4bd8_9b8f_b33b3d2bee7a
is encoded by: hsa:220
is: SBO:0000252
initial amount: NaN
is: P47895
type: Species
has only substance units: false
name: ALDH1A3
initial concentration: NaN
constant: false
boundary condition: true

metaM HC01399 m
has only substance units: false
is: CHEBI:27466
constant: false
name: (S)-3-Hydroxytetradecanoyl-CoA
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C35H58N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-24,28-30,34,43,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t23-,24+,28+,29+,30-,34+/m0/s1 EHMN_ABBREVIATION: C05260
type: Species

metaR MI145PK
is: SBO:0000176
modifier: MODEL1310110024#
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
fast: false
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.7.1.127
product: MODEL1310110024#
type: Reaction
name: inositol-1,4,5-trisphosphate 3-kinase
reactant: MODEL1310110024#

metaM creat c
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
type: Species
has only substance units: false
constant: false
is: CHEBI:16919
boundary condition: false
name: creatine
is: HMDB00064

metaM cholcoar x
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:58677
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
initial concentration: 1.0
is: SBO:0000247
is: HMDB02178
constant: false
boundary condition: false
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110024#_9b647704_2b45_4f0b_ba65_bbd5fec17fd8
is: Q92521
is encoded by: hsa:9488
initial concentration: NaN
constant: false
name: PIGB
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252

metaR EHGLAT2m
fast: false
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase 2, mitochondrial
is described by: ECO:0000304
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.6.1.1
is: SBO:0000176
reversible: false
reactant: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.21 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:NCD SAB oaa -> asp-L
product: MODEL1310110024#
modifier: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_0482472f_b83c_46a3_991b_99e0bb227935
is: P56556
boundary condition: true
is encoded by: hsa:4700
name: NDUFA6
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_422b79b8_8288_4a33_a562_a97ede40179d
is encoded by: hsa:955
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: O75354
name: ENTPD6
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_731e50f0_f52a_4a3a_ab20_bb515af6e7e9
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:BE042354
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
name: _BE042354_1_m
type: Species

metaR EX 3mlda LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-Methylimidazoleacetic acid exchange
type: Reaction

metaM ksi pre24 g
is: C00130
boundary condition: false
is: HMDB00175
notes: FORMULA: C191H306N13O158S7X CHARGE: -8
initial concentration: 1.0
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 24
initial amount: NaN
constant: false
type: Species
is: CHEBI:58053
is: SBO:0000247

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

metaM creat e
is: CHEBI:16919
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
type: Species
is: SBO:0000247
is: HMDB00064
boundary condition: false
name: creatine
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_b678453c_d0b6_4e43_92c1_26c763e3362a
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is: Q3MHC9
type: Species
is encoded by: hsa:23517
initial amount: NaN
is: SBO:0000252
name: SKIV2L2

metaM uppg3 c
is: SBO:0000247
is: C01051
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C40H36N4O16 CHARGE: -8 HEPATONET_1.0_ABBREVIATION: HC00643 EHMN_ABBREVIATION: C01051
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:57308
is: HMDB01086
name: Uroporphyrinogen III

metaM gmp c
is: CHEBI:58115
type: Species
initial concentration: 1.0
name: GMP
has only substance units: false
constant: false
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
is: HMDB01397
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: C00144

metaR FAOXC225C226m
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)m
type: Reaction

metaM ksi pre7 g
type: Species
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB00175
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C115H187N8O85SX CHARGE: -2
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 7
is: C00130

metaR 4HPRO LTte
type: Reaction
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
product: MODEL1310110024#
name: Transport of trans-4-hydroxy-L-proline
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134

metaM lac L x
type: Species
is: HMDB00190
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
boundary condition: false
has only substance units: false
name: (S)-lactate
is: CHEBI:16651
initial amount: NaN

metaR r1172
fast: false
reactant: MODEL1310110024#
is described by: ECO:0000000
name: EC:3.1.1.13
reversible: false
kinetic law: MODEL1310110024#
is: SBO:0000176
type: Reaction
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:

metaR EX tmndnc LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: timnodonic acid exchange
type: Reaction

metaR PPItr
name: Diphosphate transporter, endoplasmic reticulum
product: MODEL1310110024#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110024#_582d3399_1939_455e_b27d_f166ce254fe4
is encoded by: hsa:8310
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false
has part: O15254
name: EHHADH:ACAA1:HSD17B4:ACOX3
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110024#_4666099d_66ae_4b12_8679_6b7721537ddd
initial concentration: NaN
name: ACP1
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:52
is: B5MCC7
boundary condition: true
type: Species
constant: false

metaR PPCOACm
reversible: false
notes: GENE_ASSOCIATION: (5096.1 and 5095.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.3 Confidence Level: 4 AUTHORS: PMID:3460076,PMID:8188292 NOTES:TV
kinetic law: MODEL1310110024#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110024#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.4.1.3
reactant: MODEL1310110024#
fast: false
name: Propionyl-CoA carboxylase, mitochondrial
modifier: MODEL1310110024#

metaM mal L m
name: (S)-malate(2-)
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB00156
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
is: SBO:0000247
has only substance units: false
is: CHEBI:15589
type: Species
initial amount: NaN

metaR DOPABMO
notes: GENE_ASSOCIATION: (26002.1) or (1621.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.14.17.1 Confidence Level: 4 AUTHORS: NOTES:SAB
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.17.1
modifier: MODEL1310110024#
is: SBO:0000176
product: MODEL1310110024#
name: dopamine beta-monooxygenase
fast: false
kinetic law: MODEL1310110024#
type: Reaction
reactant: MODEL1310110024#

metaR RE2814R
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
reactant: MODEL1310110024#
reversible: true
type: Reaction
name: RE2814
product: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false

metaR P5CRxm
modifier: MODEL1310110024#
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (5831.1) or (5831.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: NOTES:PRO1x is irreversible in the other direction
type: Reaction
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.5.1.2
kinetic law: MODEL1310110024#
fast: false
name: pyrroline-5-carboxylate reductase (m)
is described by: ECO:0000304
reactant: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_e5e94f1a_f7a3_4e38_bab3_858f9310e890
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:2592
is: B4E097
has only substance units: false
initial concentration: NaN
name: GALT
type: Species
is: SBO:0000252

metaR NODe
reversible: true
product: MODEL1310110024#
name: NODe
is: SBO:0000185
type: Reaction
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_f54b5da4_e1fd_4693_b1f0_861b6d32b248
constant: false
initial concentration: NaN
name: ATP5E
is encoded by: hsa:514
type: Species
has only substance units: false
initial amount: NaN
is: P56381
is: SBO:0000252
boundary condition: true

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

metaR r1599
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
product: MODEL1310110024#
fast: false

metaR HBZOPT10m
notes: GENE_ASSOCIATION: (27235.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:15153069,PMID:1965190,PMID:7380842 NOTES:Used to make Ubiquinone-10 EC 2.5.1.- IT
product: MODEL1310110024#
modifier: MODEL1310110024#
name: Hydroxybenzoate Decaprenyltransferase
reversible: false
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110024#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.5.1.39

metaM 2mp2coa m
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
is: CHEBI:27754
has only substance units: false
boundary condition: false
is: HMDB01011
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: 2-Methylprop-2-enoyl-CoA
constant: false
type: Species

metaM asp D x
name: D-aspartate(1-)
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:29990
is: SBO:0000247
is: HMDB06483
boundary condition: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
type: Species
initial amount: NaN

metaM 44mctr r
initial amount: NaN
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
has only substance units: false
boundary condition: false
is: HMDB01023
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:17813
type: Species

metaM pe hs r
name: phosphatidylethanolamine
is: CHEBI:16038
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247

metaM pail35p hs c
type: Species
constant: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
is: CHEBI:57923
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
initial concentration: 1.0

metaM CE0693 m
is: SBO:0000247
type: Species
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
initial concentration: 1.0
initial amount: NaN
is: HMDB11123
name: 3-oxolaur-6-cis-enoyl-CoA
has only substance units: false
is: CHEBI:28387
constant: false
boundary condition: false

metaM dgtp n
boundary condition: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
constant: false
name: dGTP
initial amount: NaN
type: Species
is: SBO:0000247
is: C00286
has only substance units: false
initial concentration: 1.0
is: HMDB01440
is: CHEBI:16497

metaR r2012
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
is described by: ECO:0000000
fast: false
reversible: false
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_340873e2_500b_4cd1_a044_f01fcb9dc3bd
is encoded by: hsa:57665
has only substance units: false
is: Q9HBH5
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
name: RDH14
type: Species

metaR XYLTt
product: MODEL1310110024#
fast: false
reactant: MODEL1310110024#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES:NCD
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110024#
name: Xylitol transport via passive diffusion

http://identifiers.org/biomodels.db/MODEL1310110024#_223ec6ca_9460_4771_96e4_9a9720da26ad
initial concentration: NaN
name: AMPD3
is: B7Z763
is encoded by: hsa:272
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false

metaR r1598
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
is: SBO:0000185
type: Reaction
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
reversible: true

metaR r2013
type: Reaction
reactant: MODEL1310110024#
is described by: ECO:0000000
product: MODEL1310110024#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110024#
reversible: false
kinetic law: MODEL1310110024#

metaR EX crvnc LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC22:6 exchange
type: Reaction

metaM cholp c
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
type: Species
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
name: choline phosphate(1-)
is: SBO:0000247
is: CHEBI:295975

metaR TMNDNCt
product: MODEL1310110024#
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110024#
is: SBO:0000185
kinetic law: MODEL1310110024#
type: Reaction
name: fatty acid transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110024#_47571e7f_f1b5_4894_be0e_f571c2ec2f6a
constant: false
initial concentration: NaN
is encoded by: hsa:728441
initial amount: NaN
has only substance units: false
boundary condition: true
name: GGT2
type: Species
is: SBO:0000252

metaR XYLt
fast: false
name: D-xylose reversible transport
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
modifier: MODEL1310110024#
reversible: true
type: Reaction
product: MODEL1310110024#
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#

metaM q10 e
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:46245
is: HMDB01072
constant: false
name: ubiquinone-10

metaR EX adrn LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: adrenic acid exchange
type: Reaction

metaR r1597
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110024#
product: MODEL1310110024#
is described by: ECO:0000000
kinetic law: MODEL1310110024#
reversible: true
is: SBO:0000185
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110024#_f06a241e_9e9d_49d9_a448_346e7235c571
is: SBO:0000252
constant: false
is encoded by: hsa:100287639
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
name: _100287639_1_c

metaM retinal 11 cis c
is: HMDB02152
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
constant: false
type: Species
initial amount: NaN
name: 11-cis-retinal
initial concentration: 1.0
is: CHEBI:16066

http://identifiers.org/biomodels.db/MODEL1310110024#_1c8ab8be_ed94_412d_b187_63a95f70713c
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2181
name: ACSL3
type: Species
initial amount: NaN
constant: false
is: B3KMA6

http://identifiers.org/biomodels.db/MODEL1310110024#_41c32132_26e9_4daf_8986_b433734302f6
boundary condition: true
is: O43181
type: Species
initial amount: NaN
name: NDUFS4
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4724
is: SBO:0000252
constant: false

metaM co2 x
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: CO2 CHARGE: 0 INCHI: InChI=1S/CO2/c2-1-3 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
type: Species
is: HMDB01967
initial concentration: 1.0
name: carbon dioxide
has only substance units: false
is: CHEBI:16526

metaR PPItm
product: MODEL1310110024#
type: Reaction
fast: false
reversible: true
is described by: ECO:0000134
is: SBO:0000185
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
name: diphopshate transporter, mitochondrial

metaR NACHEX23ly
type: Reaction
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110024#
reversible: false
reactant: MODEL1310110024#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110024#
fast: false

metaM gmp g
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
type: Species
has only substance units: false
initial amount: NaN
is: HMDB01397
boundary condition: false
constant: false
initial concentration: 1.0
name: GMP(3-)
is: CHEBI:58115
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110024#_2dbe9e16_f1f3_43f6_8e79_00795f1d3fd7
constant: false
is encoded by: hsa:23236
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
is: Q9NQ66
is: SBO:0000252
initial amount: NaN
name: PLCB1

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

metaM dudp m
is: CHEBI:60471
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB01000
name: dUDP(3-)
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110024#_20d02e53_7a65_4db8_b4b0_d7ef20d06159
initial concentration: NaN
is: SBO:0000252
type: Species
name: SLCO1A2
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:6579
is: P46721

metaR FAOXC18480m
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 4 degrees loss of saturation -> only 1 fad oxidized to fadh2 peroxisomal (very long chain FA) c18:4,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000000
reactant: MODEL1310110024#
name: Beta oxidation of fatty acid
reversible: false
product: MODEL1310110024#

metaR RE1796M
name: RE1796
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
is: SBO:0000176
modifier: MODEL1310110024#
is described by: ECO:0000000
reversible: true
product: MODEL1310110024#
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.1.1.145
type: Reaction
fast: false

metaR ASNtm
reversible: false
product: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
reactant: MODEL1310110024#
is: SBO:0000185
name: L-asparagine transport, mitochondrial
kinetic law: MODEL1310110024#
fast: false
is described by: ECO:0000000

metaR r1596
reactant: MODEL1310110024#
product: MODEL1310110024#
kinetic law: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM 4abut m
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
has only substance units: false
name: 4-Aminobutanoate
constant: false
is: CHEBI:16865
is: SBO:0000247
is: HMDB00112
type: Species
initial amount: NaN
boundary condition: false
is: C00334
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110024#_26cc526e_c682_4fc5_8169_d2bb89c238f3
has only substance units: false
is encoded by: hsa:4166
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
is: Q9GZX3
name: CHST6

http://identifiers.org/biomodels.db/MODEL1310110024#_fc4f256c_8834_41ae_b7e0_70d938bdd584
type: Species
is: Q93099
has only substance units: false
constant: false
boundary condition: true
name: HGD
is: SBO:0000252
is encoded by: hsa:3081
initial concentration: NaN
initial amount: NaN

metaM ksii core4 pre6 g
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:28067
initial amount: NaN
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 6
is: SBO:0000247
type: Species
notes: FORMULA: C69H111N6O51SX CHARGE: -2

metaR P4507A1r
notes: GENE_ASSOCIATION: (1581.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.17 Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110024#
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.14.13.17
is: SBO:0000176
reactant: MODEL1310110024#
name: cytochrome P450, family 7, subfamily A, polypeptide 1
kinetic law: MODEL1310110024#
fast: false
is described by: ECO:0000269
type: Reaction
reversible: false

metaR EX oagd3 hs LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 9-O-Acetylated GD3 (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_833da4f7_7ff5_4090_a25e_a91dc8f57763
boundary condition: true
is encoded by: hsa:5831
constant: false
type: Species
has only substance units: false
is: A6NFM2
is: SBO:0000252
initial amount: NaN
name: PYCR1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_fe7cf55d_9965_4308_b65b_28fe04e434e8
is encoded by: hsa:HG2846-HT2983
name: _HG2846_HT2983_1_m
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false

metaR ACOAO7p
name: acyl-CoA oxidase (hexadecanoyl-CoA), peroxisomal
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
notes: GENE_ASSOCIATION: (51.1) or (51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: PMID:7876265,PMID:8159712 NOTES:NCD
modifier: MODEL1310110024#
reversible: false
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
type: Reaction
product: MODEL1310110024#
fast: false
is described by: ECO:0000269

metaM q10 c
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:46245
initial amount: NaN
is: HMDB01072
name: ubiquinone-10
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378

metaM hs deg7 l
name: heparan sulfate, degradation product 7
is: CHEBI:17180
notes: FORMULA: C67H99N4O80S8 CHARGE: -9
type: Species
is: HMDB01352
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false

metaR FAOXC1811602m
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110024#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110024#
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
name: Beta oxidation fatty acid

metaR r1595
reactant: MODEL1310110024#
type: Reaction
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110024#
is: SBO:0000185
reversible: true

metaM mi145p c
is: SBO:0000247
constant: false
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1 EHMN_ABBREVIATION: C01245
initial concentration: 1.0
is: CHEBI:203600
boundary condition: false
has only substance units: false
name: 1D-myo-inositol 1,4,5-trisphosphate(6-)
type: Species
is: HMDB01498
initial amount: NaN

metaR UMPK3n
is: SBO:0000176
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110024#
name: UMP kinase (UTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110024#
reversible: true
product: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110024#

metaR RE2814M
product: MODEL1310110024#
fast: false
is: SBO:0000176
is described by: ECO:0000000
name: RE2814
reactant: MODEL1310110024#
type: Reaction
reversible: true
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:

metaM hdcoa c
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB06532
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
type: Species
constant: false
name: Hexadecenoyl-CoA (n-C16:1CoA)
initial concentration: 1.0
initial amount: NaN

metaM gmp e
is: CHEBI:58115
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01397
constant: false
name: GMP(3-)
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144

metaM h2o2 m
type: Species
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
has only substance units: false
initial concentration: 1.0
is: C00027
boundary condition: false
initial amount: NaN
name: Hydrogen peroxide
constant: false
is: HMDB03125
is: CHEBI:16240
is: SBO:0000247

metaR M16NTg
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110024#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.143
reactant: MODEL1310110024#
name: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
product: MODEL1310110024#
kinetic law: MODEL1310110024#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (4247.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.143 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD

metaM C05279 m
is: CHEBI:28387
is: HMDB11123
has only substance units: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
name: trans,cis-Lauro-2,6-dienoyl-CoA

metaM maltttr e
is: HMDB01296
constant: false
type: Species
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052
has only substance units: false
name: Maltotetraose
is: http://identifiers.org/pubchem.compound/5141
initial concentration: 1.0
is: SBO:0000247
is: C02052
boundary condition: false
initial amount: NaN

metaR r1594
product: MODEL1310110024#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110024#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110024#
is described by: ECO:0000000

metaR 3SALAASPm
reversible: true
is described by: ECO:0000304
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
modifier: MODEL1310110024#
name: cysteinesulfinate-aspartate mitochondrial shuttle
is: SBO:0000185
notes: GENE_ASSOCIATION: (10165.1) or (8604.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:PMID:486467 MM
fast: false

metaR NDP10ex
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:IT
kinetic law: MODEL1310110024#
is: SBO:0000176
name: nucleoside-diphosphatase (IDP), extracellular
reactant: MODEL1310110024#
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.6
type: Reaction
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_2cabc54b_6694_4f4b_9f19_ec204797d095
initial concentration: NaN
name: SLC6A10P
is encoded by: hsa:386757
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
type: Species

metaR DCYTD
reactant: MODEL1310110024#
product: MODEL1310110024#
fast: false
is: SBO:0000176
name: deoxycytidine deaminase
type: Reaction
notes: GENE_ASSOCIATION: (978.1) or (57379.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:14744791,PMID:15087440,PMID:7923172,PMID:8001985,PMID:8422236 NOTES:
reversible: false
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.5.4.5
kinetic law: MODEL1310110024#
is described by: ECO:0000254

metaR ENGASE2ly
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110024#
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
is: SBO:0000176
name: endo-beta-N-acetylglucosaminidase, lysosomal

metaM i e
is: HMDB12238
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
name: iodide
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
initial amount: NaN
is: CHEBI:16382

metaR RE3627M
reversible: true
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110024#
name: RE3627
reactant: MODEL1310110024#
is described by: ECO:0000000
modifier: MODEL1310110024#
is: SBO:0000176

metaR NDPK9
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110024#
name: nucleoside-diphosphate kinase (ATP:IDP)
modifier: MODEL1310110024#
reversible: true
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD

metaR MG3er
reactant: MODEL1310110024#
is described by: ECO:0000000
kinetic law: MODEL1310110024#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
type: Reaction
product: MODEL1310110024#
is: SBO:0000176
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
fast: false

metaM HC00342 c
initial amount: NaN
boundary condition: false
name: cis-aconitate(3-)
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
initial concentration: 1.0
constant: false
is: CHEBI:16383

http://identifiers.org/biomodels.db/MODEL1310110024#_8c9f2a01_7900_4b7a_9094_71acc9c218d8
has only substance units: false
type: Species
initial amount: NaN
name: FOLR1
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:2348
constant: false
boundary condition: true

metaR EX dad 2 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 2-deoxyadenosine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_155829df_a3d7_4b0d_89db_86617a057172
type: Species
is encoded by: hsa:AA526438
name: _AA526438_1_c
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR DUMPtn
name: dUMP nuclear transport
kinetic law: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110024#
is: SBO:0000185
reactant: MODEL1310110024#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110024#_4079f389_f1af_4866_9383_46a2ec2dcec6
is: SBO:0000252
is encoded by: hsa:8703
initial amount: NaN
type: Species
constant: false
name: B4GALT3
initial concentration: NaN
is: A8K5Z0
has only substance units: false
boundary condition: true

metaM odecoa r
is: SBO:0000247
is: CHEBI:57387
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB01322
name: oleoyl-CoA(4-)
type: Species
boundary condition: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,26-28,32-34,38,49-50H,4-10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-/t28-,32-,33-,34+,38-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510

metaM din e
constant: false
is: C05512
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
name: Deoxyinosine
is: CHEBI:28997
is: HMDB00071
is: SBO:0000247

metaR NDPK7
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
name: nucleoside-diphosphate kinase (ATP:dCDP)
modifier: MODEL1310110024#
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
reactant: MODEL1310110024#
reversible: true
fast: false
type: Reaction

metaM CE5789 e
constant: false
initial concentration: 1.0
notes: FORMULA: C50H76N16O10 CHARGE: 2 INCHI: InChI=1/C50H74N16O10/c1-4-28(2)40(51)46(73)60-29(3)41(68)61-34(13-8-20-57-49(52)53)42(69)62-35(14-9-21-58-50(54)55)43(70)64-37(25-32-26-56-27-59-32)47(74)66-22-10-15-39(66)45(72)63-36(23-31-16-18-33(67)19-17-31)44(71)65-38(48(75)76)24-30-11-6-5-7-12-30/h5-7,11-12,16-19,26-29,34-40,67H,4,8-10,13-15,20-25,51H2,1-3H3,(H,56,59)(H,60,73)(H,61,68)(H,62,69)(H,63,72)(H,64,70)(H,65,71)(H,75,76)(H4,52,53,57)(H4,54,55,58)/p+2/t28-,29+,34-,35+,36+,37-,38-,39-,40-/m1/s1 EHMN_ABBREVIATION: CE5789
name: kinetensin 1-8
is: HMDB02710
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:27485
has only substance units: false
boundary condition: false

metaR NDPK8
product: MODEL1310110024#
name: Nucleoside-diphosphate kinase (ATP:dADP)
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
modifier: MODEL1310110024#
reversible: true
is described by: ECO:0000269

metaM ac c
is: HMDB00042
name: acetate
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
is: CHEBI:30089
has only substance units: false
type: Species

metaM strdnc r
is: http://identifiers.org/pubchem.compound/47205608
is: C16300
type: Species
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
is: SBO:0000247
name: stearidonic acid C18:4, n-3
boundary condition: false
constant: false
is: HMDB06547
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR CERT1rt
name: ceramide transport protein
fast: false
kinetic law: MODEL1310110024#
is: SBO:0000185
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.11.1
modifier: MODEL1310110024#
product: MODEL1310110024#
reversible: true
reactant: MODEL1310110024#

metaM i c
initial amount: NaN
is: CHEBI:16382
is: HMDB12238
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
name: iodide
type: Species
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708

metaR NDPK6
type: Reaction
name: Nucleoside-diphosphate kinase (ATP:dUDP)
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
reactant: MODEL1310110024#
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
is described by: ECO:0000269

metaM mal L e
is: SBO:0000247
is: HMDB00156
boundary condition: false
name: (S)-malate(2-)
is: CHEBI:15589
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_be5b426c_63c5_4eba_9c8f_aa97849554df
is: Q96P26
has only substance units: false
name: NT5C1B
is encoded by: hsa:93034
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
type: Species

metaR LACZe
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.2.1.108
modifier: MODEL1310110024#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (3938.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:5774109 NOTES:Some enzymes in this group hydrolyse a-L-arabinosides; some animal enzymes also hydrolyse b-D-fucosides and b-D-glucosides; cf. EC 3.2.1.108 lactase
is described by: ECO:0000134
reversible: false
product: MODEL1310110024#
name: b-galactosidase, extracellular
kinetic law: MODEL1310110024#
fast: false

metaR DHFR
product: MODEL1310110024#
modifier: MODEL1310110024#
is: SBO:0000176
kinetic law: MODEL1310110024#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.3
reactant: MODEL1310110024#
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
reversible: true
name: dihydrofolate reductase

metaM tridcoa m
boundary condition: false
notes: FORMULA: C34H56N7O17P3S CHARGE: -4
type: Species
initial concentration: 1.0
is: HMDB13109
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
name: tridecanoylcoa

metaR RE1836X
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.154 Confidence Level: 0 AUTHORS: PMID:10706581 NOTES:
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
name: RE1836
type: Reaction
reversible: true
fast: false
modifier: MODEL1310110024#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.3.1.176

metaR S6TASE2ly
modifier: MODEL1310110024#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110024#
kinetic law: MODEL1310110024#
reversible: true
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
name: N-acetylglucosamine-6-sulfatase, lysosomal
fast: false
reactant: MODEL1310110024#
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110024#_46d9e3f9_bcbe_4544_b52d_dc3ba69089ac
initial amount: NaN
is encoded by: hsa:54963
initial concentration: NaN
boundary condition: true
is: Q53HM1
type: Species
constant: false
has only substance units: false
is: SBO:0000252
name: UCKL1

metaM dmhptcoa m
has only substance units: false
constant: false
notes: FORMULA: C30H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C30H52N7O17P3S/c1-17(2)7-6-8-18(3)29(42)58-12-11-32-20(38)9-10-33-27(41)24(40)30(4,5)14-51-57(48,49)54-56(46,47)50-13-19-23(53-55(43,44)45)22(39)28(52-19)37-16-36-21-25(31)34-15-35-26(21)37/h15-19,22-24,28,39-40H,6-14H2,1-5H3,(H,32,38)(H,33,41)(H,46,47)(H,48,49)(H2,31,34,35)(H2,43,44,45)/p-4/t18-,19+,22-,23-,24?,28+/m0/s1
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
name: 2,6 dimethylheptanoyl-CoA
is: HMDB06258

http://identifiers.org/biomodels.db/MODEL1310110024#_755add89_d36c_4a9d_a8e1_47fe8b729d2a
initial concentration: NaN
is: SBO:0000252
name: ALG3
type: Species
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:10195

metaM din c
is: SBO:0000247
constant: false
has only substance units: false
is: C05512
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
name: Deoxyinosine
is: CHEBI:28997
is: HMDB00071

metaR NDPK5
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
product: MODEL1310110024#
reversible: true
is: SBO:0000176
fast: false
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
name: Nucleoside-diphosphate kinase (ATP:dGDP)
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6

metaM thmmp m
is: CHEBI:37575
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C12H16N4O4PS CHARGE: -1 INCHI: InChI=1S/C12H17N4O4PS/c1-8-11(3-4-20-21(17,18)19)22-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H3-,13,14,15,17,18,19)/p-1 EHMN_ABBREVIATION: C01081
name: thiamine(1+) monophosphate(2-)
boundary condition: false
has only substance units: false
is: HMDB02666
type: Species

metaR S6TASE17ly
name: N-acetylglucosamine-6-sulfatase, lysosomal
type: Reaction
kinetic law: MODEL1310110024#
is: SBO:0000176
fast: false
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.1.6.14
is described by: ECO:0000000
reactant: MODEL1310110024#
modifier: MODEL1310110024#
reversible: true
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD

metaM ac e
has only substance units: false
is: SBO:0000247
name: acetate
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:30089
initial concentration: 1.0
type: Species
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
is: HMDB00042

metaM Rtotal c
is: CHEBI:16189
notes: FORMULA: CO2FULLR CHARGE: -1
initial amount: NaN
name: R total
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
is: HMDB01448
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110024#_6924848a_305d_4079_9088_93fe70a22e6e
boundary condition: true
has only substance units: false
initial concentration: NaN
is: P56181
type: Species
is: SBO:0000252
name: NDUFV3
is encoded by: hsa:4731
initial amount: NaN
constant: false

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

metaM cs b deg3 l
boundary condition: false
notes: FORMULA: C37H55NO38S2 CHARGE: -4
is: HMDB02704
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 3
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:21338
is: SBO:0000247

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_1ae1386d_cc06_4b59_8822_2732059bb518
initial amount: NaN
name: COASY
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:80347
is: Q13057

metaR COQ6m
type: Reaction
reactant: MODEL1310110024#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (51004.1) or (51004.2) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_1.13.12.- IT
name: Ubiquinone biosynthesis monooxgenase COQ6
fast: false
reversible: false
product: MODEL1310110024#
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_ec215bcb_302e_44a8_978f_01b5da70d179
is: P13716
name: ALAD
has only substance units: false
is: SBO:0000252
type: Species
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:210
initial amount: NaN

metaM strdnc l
name: stearidonic acid C18:4, n-3
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB06547
boundary condition: false
is: C16300
is: http://identifiers.org/pubchem.compound/47205608
initial concentration: 1.0
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_09fa566a_0cdf_402e_bb06_fe62e1a63601
boundary condition: true
constant: false
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:2639
initial amount: NaN
name: GCDH

metaR r1378
reactant: MODEL1310110024#
reversible: true
is: SBO:0000176
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
product: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_aa2b41b7_c091_4feb_ac54_b685d099d184
initial amount: NaN
name: DYLX2
type: Species
is: SBO:0000252
is: F5H123
boundary condition: true
is encoded by: hsa:9856
has only substance units: false
initial concentration: NaN
constant: false

metaR H2O2t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF
is described by: ECO:0000000
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110024#
fast: false
type: Reaction
name: hydrogen peroxide transport via diffusion
product: MODEL1310110024#
reactant: MODEL1310110024#

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

metaR RE1531M
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
product: MODEL1310110024#
name: RE1531
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110024#
modifier: MODEL1310110024#
reversible: true
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
is: SBO:0000176
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_dcdedabc_4928_4c0b_9089_2009260ce576
initial concentration: NaN
constant: false
is: Q7Z7M8
name: B3GNT8
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:374907
has only substance units: false

metaR FAOXC81C61m
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)m
type: Reaction

metaR r2127
type: Reaction
fast: false
reversible: true
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110024#
reactant: MODEL1310110024#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM 4abut e
initial concentration: 1.0
notes: FORMULA: C4H9NO2 CHARGE: 0
has only substance units: false
is: CHEBI:3628
is: SBO:0000247
is: C00334
name: 4-Aminobutanoate
initial amount: NaN
is: HMDB00112
constant: false
boundary condition: false
type: Species

metaR r2343
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
reversible: true
product: MODEL1310110024#
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reactant: MODEL1310110024#
type: Reaction
fast: false

metaR r0549
is version of: http://identifiers.org/ec-code/6.1.1.17
fast: false
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
reactant: MODEL1310110024#
type: Reaction
is version of: http://identifiers.org/ec-code/1.6.99.3
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reversible: true
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.6.5.3
modifier: MODEL1310110024#
is described by: ECO:0000000

metaM asp D e
type: Species
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
boundary condition: false
name: D-aspartate(1-)
has only substance units: false
is: SBO:0000247
is: CHEBI:29990
initial amount: NaN
is: HMDB06483
initial concentration: 1.0
constant: false

metaM 13dampp c
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C3H12N2 CHARGE: 2 INCHI: InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2/p+2 EHMN_ABBREVIATION: C00986
name: trimethylenediaminium
constant: false
is: CHEBI:57484
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB00002

metaR SERCYSNaEx
product: MODEL1310110024#
name: L-serine/L-cysteine Na-dependent exchange (Ser-L in)
is described by: ECO:0000269
kinetic law: MODEL1310110024#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
reactant: MODEL1310110024#
fast: false
modifier: MODEL1310110024#

metaR FAOXC11
reactant: MODEL1310110024#
modifier: MODEL1310110024#
product: MODEL1310110024#
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 2 AUTHORS: PMID:9819701 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211 1 round of beta ox of branched chain FA from peroxisome NJ
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110024#
is: SBO:0000176

metaR RE3421R
type: Reaction
reversible: true
name: RE3421
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
reactant: MODEL1310110024#
is described by: ECO:0000000
is: SBO:0000176
fast: false
product: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_f5b05756_78fc_457f_8958_169f448dfb2e
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
is: O95395
name: GCNT3
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:9245
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_73af0332_0c42_4777_bb50_e9d8330fc4db
initial amount: NaN
constant: false
name: _AA526438_1_m
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:AA526438
initial concentration: NaN

metaR RE0944E
name: RE0944
modifier: MODEL1310110024#
fast: false
product: MODEL1310110024#
reactant: MODEL1310110024#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.17
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.1
is: SBO:0000176
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:

metaR r2126
kinetic law: MODEL1310110024#
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110024#
modifier: MODEL1310110024#
reactant: MODEL1310110024#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110024#_a554428b_3e69_45e9_ae5a_e1decb7d30b9
type: Species
has only substance units: false
initial concentration: NaN
is: O14734
initial amount: NaN
constant: false
name: ACOT8
is encoded by: hsa:10005
boundary condition: true
is: SBO:0000252

metaR r1177
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is: SBO:0000176
type: Reaction
product: MODEL1310110024#
name: EC:3.1.1.13
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
is described by: ECO:0000000
fast: false

metaM odecoa m
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
is: HMDB01322
has only substance units: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
name: Octadecenoyl-CoA (n-C18:1CoA)
is: CHEBI:57387

metaR UMPKn
is: SBO:0000176
reactant: MODEL1310110024#
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
fast: false
name: UMP kinase, nuclear
modifier: MODEL1310110024#
reversible: true
type: Reaction
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110024#_65b53db7_4123_4985_b530_a513b0d8a0e0
is: SBO:0000252
constant: false
has only substance units: false
name: CH25H
type: Species
boundary condition: true
is: O95992
initial amount: NaN
is encoded by: hsa:9023
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_44e2e330_2458_4ba4_9d91_ea0e86277981
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3033
initial amount: NaN
initial concentration: NaN
name: HADH
constant: false
boundary condition: true
type: Species
is: Q16836

metaR FAOXC61C4x
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)x
type: Reaction

metaR r2129
is described by: ECO:0000000
reactant: MODEL1310110024#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
type: Reaction
fast: false
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110024#
kinetic law: MODEL1310110024#

metaR CREATt4 2 r
name: Creatine transport (sodium symport) (2:1)
reactant: MODEL1310110024#
type: Reaction
kinetic law: MODEL1310110024#
fast: false
product: MODEL1310110024#
modifier: MODEL1310110024#
is described by: ECO:0000269
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110024#_4181457c_3747_44f9_ab39_76501b404223
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: O94788
boundary condition: true
is encoded by: hsa:8854
name: ALDH1A2
constant: false

metaR r2341
name: Organic anion transporter 5 Utilized transport
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110024#
is: SBO:0000185
reactant: MODEL1310110024#
type: Reaction
fast: false

metaR GDPtg
name: GDP intracellular transport
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - likely translocated, unknown transporter/mechanism though NJ
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
product: MODEL1310110024#

metaM asp D c
name: D-aspartate(1-)
is: SBO:0000247
is: HMDB06483
is: CHEBI:29990
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
boundary condition: false
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN

metaM dgchol x
initial amount: NaN
is: HMDB00637
constant: false
boundary condition: false
type: Species
has only substance units: false
name: glycochenodeoxycholate
initial concentration: 1.0
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
is: CHEBI:36252
is: SBO:0000247

metaR r2128
reactant: MODEL1310110024#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110024#
is described by: ECO:0000000
kinetic law: MODEL1310110024#
reversible: true
type: Reaction
modifier: MODEL1310110024#

metaR r1377
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110024#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false
reversible: true
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22

metaR TMDPK
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.7.6.2
fast: false
reactant: MODEL1310110024#
modifier: MODEL1310110024#
reversible: false
name: Thiamin pyrophosphokinase (EC 2.7.6.2)
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (27010.1) SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269

metaR PAFH
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.1.47
product: MODEL1310110024#
name: Platelet-activating factor acetylhydrolase
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (5051.1) or (5049.1 and 5050.1) or (5049.1 and 5050.1 and 5048.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.47 Confidence Level: 4 AUTHORS: PMID:7669037,PMID:8028668,PMID:8955149 NOTES:NJ
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110024#_d49e922b_0b3e_45ea_82de_fb0d32996550
constant: false
is: Q9NVS9
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:55163
is: SBO:0000252
boundary condition: true
name: PNPO
has only substance units: false

metaR PROSTGD2t
reactant: MODEL1310110024#
is: SBO:0000185
kinetic law: MODEL1310110024#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
fast: false
is described by: ECO:0000269
modifier: MODEL1310110024#
name: prostaglandin transport via bicarbonate countertransport
product: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_11de6338_35fd_4666_9089_d228faa995d9
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:5286
is: O00443
name: PIK3C2A
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR CHOLATEt
reversible: true
is described by: ECO:0000269
type: Reaction
name: cholate transport via bicarbonate countertransport
product: MODEL1310110024#
fast: false
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
modifier: MODEL1310110024#
is: SBO:0000185
reactant: MODEL1310110024#

metaM crn r
is: SBO:0000247
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial concentration: 1.0
is: CHEBI:16347
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: HMDB00062
name: (R)-carnitine
boundary condition: false

metaR FAOXC14DCC12DCx
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14DC-->C12DC)x
type: Reaction

metaR r0545
is described by: ECO:0000000
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
type: Reaction
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.6.1.5
is: SBO:0000176
reversible: true
fast: false

metaR SQLSr
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ
fast: false
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
is described by: ECO:0000134
name: Squalene synthase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.5.1.21
reactant: MODEL1310110024#
product: MODEL1310110024#

metaR r2347
kinetic law: MODEL1310110024#
fast: false
reactant: MODEL1310110024#
type: Reaction
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
product: MODEL1310110024#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000

metaR FAOXC8C6x
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8-->C6)x
type: Reaction

metaR r2123
reactant: MODEL1310110024#
type: Reaction
modifier: MODEL1310110024#
reversible: true
product: MODEL1310110024#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110024#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR EX hpdca LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptadecanoate exchange
type: Reaction

metaR EX ha LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_d4f1f182_b219_4e45_aeb7_61f8afc6357e
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:50484
name: RRM2B
is: Q7LG56

metaR ALOX52
is: SBO:0000176
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:cofactors + usage still not clear unknown mechanism - biochemistry supported by PMID: 2829172, 11160764
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110024#
reversible: false
name: Arachidonate 5-lipoxygenase
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.13.11.34

http://identifiers.org/biomodels.db/MODEL1310110024#_4d9dd1ec_84e4_4788_afed_a114a8610f9e
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
name: DHFR
type: Species
is encoded by: hsa:1719
is: P00374
initial amount: NaN
constant: false

metaM pydx5p c
type: Species
initial concentration: 1.0
notes: FORMULA: C8H8NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00028 EHMN_ABBREVIATION: C00018
has only substance units: false
is: HMDB01491
is: C00018
constant: false
name: Pyridoxal 5'-phosphate
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:597326

metaR B MANNASEly
modifier: MODEL1310110024#
reactant: MODEL1310110024#
name: beta-mannosidase, lysosomal
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.25
kinetic law: MODEL1310110024#
fast: false
is described by: ECO:0000000
product: MODEL1310110024#
reversible: false
notes: GENE_ASSOCIATION: (4126.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.25 Confidence Level: 0 AUTHORS: PMID:9384606 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110024#_0b693874_cfdc_4690_8d74_8c6176b93ff5
boundary condition: true
has part: Q9NZL9
initial amount: NaN
name: MAT2B:MAT2A
is: SBO:0000297
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is encoded by: hsa:27430

metaR r0617
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
type: Reaction
is: SBO:0000176
fast: false
reversible: true
reactant: MODEL1310110024#
product: MODEL1310110024#
kinetic law: MODEL1310110024#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:

metaR r2346
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110024#
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
product: MODEL1310110024#
kinetic law: MODEL1310110024#
type: Reaction
fast: false

metaR r2122
product: MODEL1310110024#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110024#
fast: false
modifier: MODEL1310110024#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
reactant: MODEL1310110024#
is described by: ECO:0000000

metaM dadp c
initial amount: NaN
is: HMDB01508
boundary condition: false
name: dADP
has only substance units: false
type: Species
is: SBO:0000247
is: C00206
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
constant: false
initial concentration: 1.0
is: CHEBI:57667

metaM CE4872 c
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
is: HMDB00127
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:15748

http://identifiers.org/biomodels.db/MODEL1310110024#_de70044e_23f1_4737_806d_10c097368be0
constant: false
initial amount: NaN
name: ATP2B4
boundary condition: true
initial concentration: NaN
is encoded by: hsa:493
is: P23634
type: Species
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_d40525a9_bc7f_45fa_bdbd_485c15ad58ef
initial amount: NaN
boundary condition: true
constant: false
is: Q9UHW9
name: SLC12A6
has only substance units: false
is: SBO:0000252
is encoded by: hsa:9990
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_78d611fa_75bc_488a_937c_52c7e1c0c3f5
initial concentration: NaN
name: _H17063_1_c
type: Species
is encoded by: hsa:H17063
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110024#_4863420d_7007_4ef6_b330_fa07891ff8e6
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:4247
initial amount: NaN
name: MGAT2
is: SBO:0000252
constant: false
is: Q10469

metaR FAOXC143C123x
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:3-->C12:3)x
type: Reaction

metaR r0616
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
fast: false
is described by: ECO:0000000
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
is: SBO:0000176
reversible: true
modifier: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_17d7d252_abf6_484d_9c39_98e65e943607
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:8790
type: Species
has only substance units: false
name: FPGT
is: O14772

http://identifiers.org/biomodels.db/MODEL1310110024#_7e40f1fb_a268_4ea9_8c71_496987454609
is encoded by: hsa:51292
type: Species
constant: false
name: GMPR2
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR r2125
reversible: true
fast: false
reactant: MODEL1310110024#
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
product: MODEL1310110024#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction

metaM 4abut c
boundary condition: false
notes: FORMULA: C4H9NO2 CHARGE: 0
has only substance units: false
initial amount: NaN
is: HMDB00112
is: CHEBI:3628
name: 4-Aminobutanoate
constant: false
initial concentration: 1.0
is: C00334
type: Species
is: SBO:0000247

metaR TKT2
reactant: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
fast: false
is version of: http://identifiers.org/ec-code/2.2.1.1
is described by: ECO:0000000
is: SBO:0000176
name: transketolase
reversible: true

metaR S6TASE14ly
modifier: MODEL1310110024#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
product: MODEL1310110024#
type: Reaction
name: N-acetylglucosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.14
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110024#_6771e79e_9742_41f7_99f0_6c37416bc4b5
initial amount: NaN
is encoded by: hsa:8310
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
is: O15254
name: ACOX3

metaR EX met L LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Methionine exchange
type: Reaction

metaR EX 3aib LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-3-Amino-isobutanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_60d720b9_c1ad_48dd_9c74_090076c85f20
is: SBO:0000252
is: Q8TCD5
has only substance units: false
name: NT5C
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:30833

http://identifiers.org/biomodels.db/MODEL1310110024#_d864b424_48af_4f99_bde6_bfa9107482fa
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
name: HMGCS2
initial amount: NaN
type: Species
has only substance units: false
is: P54868
is encoded by: hsa:3158

metaR TAURt4 2 r
is: SBO:0000185
name: taurine transport (sodium symport) (2:1)
modifier: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000269
fast: false
type: Reaction
product: MODEL1310110024#
reversible: true
notes: GENE_ASSOCIATION: (6533.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
kinetic law: MODEL1310110024#

metaM 2docohexecoa m
is: http://identifiers.org/pubchem.compound/24892790
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
constant: false
type: Species
is: SBO:0000247
name: 2,7,10,13,16,19-docosahexenoylcoa
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_d9ba5535_a2fa_4c84_8580_d0ce16d70884
is encoded by: hsa:23439
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: ATP1B4
type: Species
constant: false
is: Q9UN42
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110024#_5ff68431_ccde_4e68_98fa_5ba972f450ba
has only substance units: false
initial amount: NaN
name: CANT1
is: SBO:0000252
type: Species
is encoded by: hsa:124583
initial concentration: NaN
boundary condition: true
is: Q8WVQ1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_b4ce11bb_31c7_4f7c_9d21_f3dfc5634039
is encoded by: hsa:3938
name: LCT
boundary condition: true
is: P09848
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false

metaR PGMT
modifier: MODEL1310110024#
is described by: ECO:0000134
reversible: true
product: MODEL1310110024#
fast: false
kinetic law: MODEL1310110024#
type: Reaction
name: phosphoglucomutase
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/5.4.2.2
is: SBO:0000176
notes: GENE_ASSOCIATION: (5236.1) or (55276.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.4.2.2 Confidence Level: 0 AUTHORS: PMID:4829444 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110024#_55e22c63_38cd_4e40_94ae_ebc6c8b52063
constant: false
initial amount: NaN
name: AMPD2
type: Species
is encoded by: hsa:271
has only substance units: false
is: SBO:0000252
is: B2RB47
boundary condition: true
initial concentration: NaN

metaR r2344
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
reversible: true
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
product: MODEL1310110024#
reactant: MODEL1310110024#
is: SBO:0000185
kinetic law: MODEL1310110024#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110024#_0b95e72a_88e8_4c8f_99fb_50737b57d5c6
initial concentration: NaN
boundary condition: true
is: P20674
has only substance units: false
constant: false
name: COX5A
type: Species
is encoded by: hsa:9377
initial amount: NaN
is: SBO:0000252

metaR r0615
is described by: ECO:0000000
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
fast: false
notes: GENE_ASSOCIATION: (1629.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
reversible: true
type: Reaction
is: SBO:0000176
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.3.1.168
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#

metaR TKT1
modifier: MODEL1310110024#
type: Reaction
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
name: transketolase
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.2.1.1
reversible: true
fast: false

metaR r2124
reactant: MODEL1310110024#
is: SBO:0000185
kinetic law: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110024#
fast: false

metaM fn2m2masn g
boundary condition: false
constant: false
name: N4-{N-Acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C56H93N4O39X CHARGE: 0 INCHI: InChI=1S/C60H100N6O42/c1-14-32(77)42(87)45(90)57(96-14)94-13-26-48(40(85)28(62-15(2)72)52(97-26)66-27(76)6-19(61)53(92)93)104-56-31(65-18(5)75)41(86)47(24(11-71)102-56)105-58-46(91)49(106-60-51(44(89)36(81)23(10-70)101-60)108-55-30(64-17(4)74)39(84)34(79)21(8-68)99-55)37(82)25(103-58)12-95-59-50(43(88)35(80)22(9-69)100-59)107-54-29(63-16(3)73)38(83)33(78)20(7-67)98-54/h14,19-26,28-52,54-60,67-71,77-91H,6-13,61H2,1-5H3,(H,62,72)(H,63,73)(H,64,74)(H,65,75)(H,66,76)(H,92,93)/t14-,19-,20+,21+,22+,23+,24+,25+,26+,28+,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43-,44-,45-,46-,47+,48+,49-,50-,51-,52+,54-,55-,56-,57+,58-,59-,60+/m0/s1
is: CHEBI:32984

metaR ADPCOACROT
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of adipoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_9c4c6cd1_0177_4ad6_b5f2_541e6cab6048
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
name: SLC5A2
is encoded by: hsa:6524
is: P31639

http://identifiers.org/biomodels.db/MODEL1310110024#_20bfec84_6bb6_4f96_9947_db22030a199a
has only substance units: false
name: ABAT
boundary condition: true
constant: false
is: SBO:0000252
is: P80404
is encoded by: hsa:18
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_1e097115_abb6_45cf_8e44_d6c749f0b3e7
type: Species
name: CA9
constant: false
is: SBO:0000252
is encoded by: hsa:768
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
is: Q16790

metaR FAOXC181C181OHm
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:1-->C18:1OH)m
type: Reaction

metaM lgt S c
constant: false
is: HMDB01066
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C13H20N3O8S CHARGE: -1 INCHI: InChI=1S/C13H21N3O8S/c1-6(17)13(24)25-5-8(11(21)15-4-10(19)20)16-9(18)3-2-7(14)12(22)23/h6-8,17H,2-5,14H2,1H3,(H,15,21)(H,16,18)(H,19,20)(H,22,23)/p-1/t6-,7+,8+/m1/s1
has only substance units: false
name: (R)-S-lactoylglutathionate(1-)
boundary condition: false
is: CHEBI:57474
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110024#_fdee0e8f_61d5_4232_9edd_304205a3d62e
is encoded by: hsa:3177
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: Q14542
has only substance units: false
boundary condition: true
constant: false
type: Species
name: SLC29A2

metaR AG13T2g
type: Reaction
product: MODEL1310110024#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110024#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110024#
fast: false
modifier: MODEL1310110024#
is: SBO:0000176

metaR S6TASE25ly
fast: false
is: SBO:0000176
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110024#
reactant: MODEL1310110024#
name: galactose-6-sulfate sulfatase, lysosomal
kinetic law: MODEL1310110024#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4

metaR LEULEULAPc
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: hydrolysis of Leucylleucine in the small intestine for cellular uptake
type: Reaction

metaR RE3301C
fast: false
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.1.4.4
reversible: true
is: SBO:0000176
product: MODEL1310110024#
name: RE3301
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:11182251 NOTES:
reactant: MODEL1310110024#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_c5e8099e_f319_4e9d_8499_d4f9e6e75281
has part: H7C5B8
is encoded by: hsa:4707
is encoded by: hsa:51079
has part: Q6IB80
has part: Q6IBB5
has part: Q7GXZ1
boundary condition: true
has part: Q7GXY9
is encoded by: hsa:4723
constant: false
is encoded by: hsa:4704
has part: Q7GXZ4
is encoded by: hsa:4697
is encoded by: hsa:4718
has part: Q9Y6M9
has part: P17568
has part: O43678
has part: O00483
has part: O95299
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
is encoded by: hsa:4702
has part: O00217
has part: P28331
has part: A8K761
is encoded by: hsa:4537
has part: O14561
has part: O95169
has part: E5KNH5
is encoded by: hsa:4720
is encoded by: hsa:4700
is encoded by: hsa:4541
is encoded by: hsa:4729
is encoded by: hsa:4709
is encoded by: hsa:4719
initial concentration: NaN
is encoded by: hsa:4705
is encoded by: hsa:4715
is encoded by: hsa:4710
has part: P03915
has part: O43677
has part: Q6IBA0
has part: B7Z792
is encoded by: hsa:374291
has part: Q13454
has only substance units: false
has part: F8VQS7
is encoded by: hsa:4713
is encoded by: hsa:4535
is encoded by: hsa:4694
is encoded by: hsa:126328
is encoded by: hsa:4706
is encoded by: hsa:4539
initial amount: NaN
is encoded by: hsa:4540
is encoded by: hsa:4538
has part: P56556
is encoded by: hsa:55967
is encoded by: hsa:4722
has part: O75438
is encoded by: hsa:4731
is encoded by: hsa:4701
is encoded by: hsa:4711
has part: O95168
has part: Q9P0J0
has part: Q16795
has part: Q549M5
has part: O75251
has part: Q6FG42
has part: O43181
has part: P56181
is encoded by: hsa:7991
is encoded by: hsa:4724
is encoded by: hsa:4716
has part: P19404
has part: O75489
has part: C9JT23
has part: O43674
is encoded by: hsa:4714
is: SBO:0000297
is encoded by: hsa:4536

metaM mal L c
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
boundary condition: false
is: CHEBI:15589
has only substance units: false
is: SBO:0000247
type: Species
name: (S)-malate(2-)
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB00156

http://identifiers.org/biomodels.db/MODEL1310110024#_0431a6a2_ca4b_4bdc_a68c_8b90a4323aec
type: Species
name: HSD3B2
is encoded by: hsa:3284
has only substance units: false
constant: false
is: P26439
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaR r0541
product: MODEL1310110024#
reactant: MODEL1310110024#
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
is described by: ECO:0000000
kinetic law: MODEL1310110024#
reversible: true
fast: false
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.6.1.5
type: Reaction
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
is: SBO:0000176

metaR NDPK4
type: Reaction
is described by: ECO:0000269
name: nucleoside-diphosphate kinase (ATP:dTDP)
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
modifier: MODEL1310110024#
is: SBO:0000176
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
reversible: true
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR EX prostgi2 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin I2(1-) exchange
type: Reaction

metaR ARGtm
reactant: MODEL1310110024#
type: Reaction
modifier: MODEL1310110024#
is described by: ECO:0000269
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is: SBO:0000185
fast: false
product: MODEL1310110024#
name: arginine mitochondrial transport via ornithine carrier
reversible: true

metaR VLCS2p
kinetic law: MODEL1310110024#
product: MODEL1310110024#
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: false
reactant: MODEL1310110024#
type: Reaction
name: Very-long-chain-fatty-acid-CoA ligase
is described by: ECO:0000304
fast: false
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: PMID:10479480 NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
is: SBO:0000176

metaM Rtotal e
is: C00255
constant: false
is: HMDB00244
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
name: R total
notes: FORMULA: CO2FULLR CHARGE: -1
has only substance units: false
is: CHEBI:3554

metaR RBFK
type: Reaction
is described by: ECO:0000269
fast: false
reactant: MODEL1310110024#
reversible: false
name: riboflavin kinase
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.26
kinetic law: MODEL1310110024#
is: SBO:0000176
modifier: MODEL1310110024#
product: MODEL1310110024#

metaM crn x
is: CHEBI:16347
boundary condition: false
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
name: L-Carnitine
is: C00318
is: SBO:0000247
is: HMDB00062
initial concentration: 1.0
has only substance units: false

metaR MI145PP
modifier: MODEL1310110024#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
reactant: MODEL1310110024#
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.56
kinetic law: MODEL1310110024#
reversible: false
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.1.3.36
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.86
type: Reaction
name: inositol-1,4,5-trisphosphate 5-phosphatase

http://identifiers.org/biomodels.db/MODEL1310110024#_a51c055f_f32c_4604_864b_02046b7a62bf
type: Species
name: GGT1
constant: false
is: SBO:0000252
is: P19440
boundary condition: true
initial amount: NaN
is encoded by: hsa:2678
initial concentration: NaN
has only substance units: false

metaM strdnc e
type: Species
is: C16300
is: HMDB06547
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: stearidonic acid C18:4, n-3
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/47205608
has only substance units: false

metaR NDPK3
notes: GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
product: MODEL1310110024#
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:CDP)
reactant: MODEL1310110024#
type: Reaction
reversible: true

metaR OROTGLUt
fast: false
product: MODEL1310110024#
reversible: true
kinetic law: MODEL1310110024#
type: Reaction
reactant: MODEL1310110024#
name: OROTGLUt
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134

metaM 2dr1p c
is: HMDB01351
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
initial concentration: 1.0
is: C00672
constant: false
is: CHEBI:58576
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: 2-Deoxy-D-ribose 1-phosphate
type: Species
boundary condition: false

metaM doldp L r
initial amount: NaN
is: CHEBI:15750
is: SBO:0000247
notes: FORMULA: C1080H1758O70P20 CHARGE: -30 INCHI: InChI=1S/C25H46O7P2/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-31-34(29,30)32-33(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H,29,30)(H2,26,27,28)/b22-13+,23-15+,24-17-
constant: false
type: Species
boundary condition: false
has only substance units: false
name: Dolichol diphosphate, human liver homolog
initial concentration: 1.0

metaR PAFS
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 0 AUTHORS: NOTES:NJ
type: Reaction
product: MODEL1310110024#
fast: false
kinetic law: MODEL1310110024#
reversible: false
is: SBO:0000176
name: alkyl glycerol phosphocholine acetyl transferase
reactant: MODEL1310110024#
is described by: ECO:0000000

metaR r2121
type: Reaction
product: MODEL1310110024#
modifier: MODEL1310110024#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110024#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110024#

metaR LEUTAm
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
reversible: true
product: MODEL1310110024#
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.42
name: leucine transaminase, mitochondrial
kinetic law: MODEL1310110024#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110024#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110024#_dd1877fe_f0cb_44df_94de_201d7cf2b35a
is: O15121
name: DEGS1
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:8560
has only substance units: false
constant: false
is: SBO:0000252

metaR CLFORtex
type: Reaction
modifier: MODEL1310110024#
product: MODEL1310110024#
name: chloride transport via formate countertransport
fast: false
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (5172.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110024#_c1dad79a_e611_4d13_b327_7d0d44dd6e7d
name: _NM_013421_1_e
is encoded by: hsa:NM 013421
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN

metaM HC01115 c
is: CHEBI:29025
name: NeuNGc
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410

metaR NDPK2
kinetic law: MODEL1310110024#
fast: false
name: nucleoside-diphosphate kinase (ATP:UDP)
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110024#
reactant: MODEL1310110024#
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR TAGt
product: MODEL1310110024#
fast: false
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
type: Reaction
reversible: true
kinetic law: MODEL1310110024#
is described by: ECO:0000000
name: triacylglycerol transport

metaR THFtm
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
product: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_d8f15143_bd7f_4c6d_ab07_4c3782a0507b
is encoded by: hsa:4731
has only substance units: false
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: P56181
name: NDUFV3

metaM g1m8mpdol U r
has only substance units: false
boundary condition: false
is: CHEBI:59093
type: Species
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: SBO:0000247
notes: FORMULA: C1785H2940N20O670P20 CHARGE: -20
constant: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110024#_91911115_ca47_47dc_a3fe_a260ab6ada37
boundary condition: true
name: ETFA:ETFB
type: Species
has only substance units: false
is: SBO:0000297
has part: P38117
constant: false
is encoded by: hsa:2109
initial concentration: NaN
initial amount: NaN

metaM pydx5p e
is: HMDB01491
constant: false
type: Species
name: pyridoxal 5'-phosphate(2-)
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:597326
initial amount: NaN
notes: FORMULA: C8H8NO6P CHARGE: -2 INCHI: InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)/p-2 HEPATONET_1.0_ABBREVIATION: HC00028 EHMN_ABBREVIATION: C00018
boundary condition: false
has only substance units: false

metaM hs deg16 l
notes: FORMULA: C49H72N2O54S4 CHARGE: -6
is: SBO:0000247
type: Species
name: heparan sulfate, degradation product 16
has only substance units: false
is: CHEBI:21338
constant: false
initial amount: NaN
is: HMDB02704
initial concentration: 1.0
boundary condition: false

metaM cs a deg4 l
notes: FORMULA: C31H49NO29S CHARGE: -2
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 4
constant: false
has only substance units: false
is: HMDB01354
initial concentration: 1.0
is: CHEBI:57455

metaR NACHEX22ly
fast: false
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110024#
product: MODEL1310110024#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110024#_16008356_fd2d_4750_af9b_6b440de981df
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
is: Q02338
boundary condition: true
type: Species
is encoded by: hsa:622
has only substance units: false
name: BDH1

metaR C4CRNCPT2
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of butyryl carnitine in the mitochondrial matrix for final hydrolysis
type: Reaction

metaR r2120
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110024#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
reactant: MODEL1310110024#
is described by: ECO:0000000
product: MODEL1310110024#

metaM odecoa c
initial amount: NaN
is: HMDB01322
name: Octadecenoyl-CoA (n-C18:1CoA)
has only substance units: false
is: CHEBI:3793
constant: false
boundary condition: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
is: SBO:0000247
initial concentration: 1.0
type: Species

metaR ADK3m
kinetic law: MODEL1310110024#
reversible: true
fast: false
type: Reaction
is described by: ECO:0000269
name: adentylate kinase (GTP)
product: MODEL1310110024#
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.7.4.10
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110024#_619ff9b6_3343_4ee7_8815_1580a7953bc7
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
name: PNPLA4
is encoded by: hsa:8228
is: P41247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_15f0fcf4_73c1_409f_899c_0e861b429716
is: SBO:0000252
type: Species
is: Q15102
constant: false
initial amount: NaN
is encoded by: hsa:5050
initial concentration: NaN
has only substance units: false
name: PAFAH1B3
boundary condition: true

metaR NDPK1
product: MODEL1310110024#
name: nucleoside-diphosphate kinase (ATP:GDP)
modifier: MODEL1310110024#
type: Reaction
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
is described by: ECO:0000134
is: SBO:0000176
reactant: MODEL1310110024#
reversible: true

metaR FAOXC7C5m
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C7-->C5)m
type: Reaction

metaM CE5132 c
is: CHEBI:57923
type: Species
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
constant: false
boundary condition: false
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaM nmn n
notes: FORMULA: C11H14N2O8P CHARGE: -1 INCHI: InChI=1S/C11H15N2O8P/c12-10(16)6-2-1-3-13(4-6)11-9(15)8(14)7(21-11)5-20-22(17,18)19/h1-4,7-9,11,14-15H,5H2,(H3-,12,16,17,18,19)/p-1/t7-,8-,9-,11-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
boundary condition: false
is: SBO:0000247
is: CHEBI:14649
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00229
name: NMN(-)
constant: false
type: Species

metaR NaKt
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (481.1 and 478.1) or (477.1 and 23439.1) or (483.1 and 476.1) or (481.1 and 480.1) or (482.1 and 478.1) or (482.1 and 476.1) or (482.1 and 477.1) or (481.1 and 476.1) or (23439.1 and 476.1) or (480.1 and 23439.1) or (481.1 and 477.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.9 Confidence Level: 4 AUTHORS: PMID:10456317,PMID:8833915,PMID:9159180 NOTES:AMF TDV (8/25/2005, stoichiometry changed)
type: Reaction
product: MODEL1310110024#
fast: false
is version of: http://identifiers.org/ec-code/3.6.3.9
kinetic law: MODEL1310110024#
is: SBO:0000185
reversible: false
modifier: MODEL1310110024#
is described by: ECO:0000269
name: Na+/K+ exchanging ATPase

metaM strdnc c
name: stearidonic acid C18:4, n-3
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
is: SBO:0000247
has only substance units: false
is: C16300
constant: false
is: http://identifiers.org/pubchem.compound/47205608
is: HMDB06547
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN

metaR G14T3g
is described by: ECO:0000000
reactant: MODEL1310110024#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
modifier: MODEL1310110024#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110024#
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.4.1.38
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

http://identifiers.org/biomodels.db/MODEL1310110024#_6dbbd893_e775_4e7e_a436_24bf09a9c7ba
initial amount: NaN
type: Species
is encoded by: hsa:2109
constant: false
has only substance units: false
name: ETFB
is: P38117
boundary condition: true
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_d24aea0b_c97a_49d9_ad96_533f46b2adad
type: Species
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: Q9Y2A9
is encoded by: hsa:10331
name: B3GNT3

metaR r2328
fast: false
is: SBO:0000185
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110024#
kinetic law: MODEL1310110024#
is described by: ECO:0000000
reactant: MODEL1310110024#
reversible: true

metaM ksi pre1 g
is: C00130
initial amount: NaN
notes: FORMULA: C79H129N5O57X CHARGE: -1
type: Species
constant: false
is: CHEBI:58053
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 1
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110024#_2d47915c_e937_454a_aeeb_2adba0025642
name: SLC6A5
type: Species
is: SBO:0000252
boundary condition: true
is: Q9Y345
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:9152
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_8f23046e_dd04_4bb3_b586_2147d8f5bac8
is encoded by: hsa:1609
has only substance units: false
name: DGKQ
is: P52824
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_53b22d4d_197f_4560_a869_31f149c8601a
name: NOS3
initial amount: NaN
is: SBO:0000252
constant: false
is: A0S0A7
boundary condition: true
is encoded by: hsa:4846
type: Species
has only substance units: false
initial concentration: NaN

metaR OCT11EFATP
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of vaccenic acid by cells
type: Reaction

metaR DCSPTN1CPT2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
fast: false
type: Reaction
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
name: carnitine transferase
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
product: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_5ec12bba_cf0a_4f5c_8960_9bb1c57a1954
is encoded by: hsa:3945
has only substance units: false
name: LDHA:LDHB
has part: P07195
initial amount: NaN
is encoded by: hsa:3939
initial concentration: NaN
boundary condition: true
has part: P00338
constant: false
type: Species
is: SBO:0000297

metaR FACOAL203
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
name: fatty-acid--CoA ligase
fast: false
reversible: true
is: SBO:0000176
product: MODEL1310110024#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110024#
type: Reaction
reactant: MODEL1310110024#

metaR r0409
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110024#
type: Reaction
is: SBO:0000176
product: MODEL1310110024#
name: UTP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
notes: GENE_ASSOCIATION: (6476.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275 NOTES:
reactant: MODEL1310110024#
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.10
modifier: MODEL1310110024#

metaR PALFATPtc
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Hexadecanoate by the enterocytes
type: Reaction

metaM mpdol L c
has only substance units: false
type: Species
constant: false
is: SBO:0000247
boundary condition: false
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human liver homolog
is: CHEBI:18396
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C1300H2128N20O220P20 CHARGE: -20 INCHI: InChI=1S/C47H82N2O22P2/c1-26(2)13-9-14-27(3)15-10-16-28(4)17-11-18-29(5)19-12-20-30(6)21-22-64-72(60,61)71-73(62,63)70-46-37(49-32(8)54)40(57)43(35(25-52)67-46)68-45-36(48-31(7)53)39(56)44(34(24-51)66-45)69-47-42(59)41(58)38(55)33(23-50)65-47/h13,15,17,19,30,33-47,50-52,55-59H,9-12,14,16,18,20-25H2,1-8H3,(H,48,53)(H,49,54)(H,60,61)(H,62,63)/b27-15+,28-17+,29-19+/t30?,33-,34-,35-,36-,37-,38-,39-,40-,41+,42+,43-,44-,45+,46-,47+/m1/s1

metaM saccrp L m
is: HMDB00279
has only substance units: false
name: L-saccharopinate(1-)
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
constant: false
is: CHEBI:57951
is: SBO:0000247
notes: FORMULA: C11H19N2O6 CHARGE: -1 INCHI: InChI=1S/C11H20N2O6/c12-7(10(16)17)3-1-2-6-13-8(11(18)19)4-5-9(14)15/h7-8,13H,1-6,12H2,(H,14,15)(H,16,17)(H,18,19)/p-1/t7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00363

metaR ARACHCRNt
reactant: MODEL1310110024#
modifier: MODEL1310110024#
is described by: ECO:0000000
name: transport into the mitochondria (carnitine)
type: Reaction
reversible: false
fast: false
product: MODEL1310110024#
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000185

metaR DOCO13EFATP
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: absorption or uptake of 13-docosenoic acid into cells
type: Reaction

metaR r1078
reversible: false
kinetic law: MODEL1310110024#
name: Vesicular transport
reactant: MODEL1310110024#
fast: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

metaR FATP1t
fast: false
reactant: MODEL1310110024#
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (376497.2) or (10999.1) or (376497.1) or (11000.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816,PMID:9878842 NOTES:electroneutral transport NJ
type: Reaction
is: SBO:0000185
product: MODEL1310110024#
name: fatty acid electroneutral transport
is described by: ECO:0000269
reversible: true

metaM h x
has only substance units: false
is: C00080
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: http://identifiers.org/pubchem.compound/3380
name: proton
is: CHEBI:24636
constant: false
initial amount: NaN
boundary condition: false

metaM dctp c
boundary condition: false
type: Species
is: HMDB00998
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
name: dCTP
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:16311
is: C00458

metaR r2329
reactant: MODEL1310110024#
fast: false
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
reversible: true
product: MODEL1310110024#
type: Reaction
kinetic law: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_7fe040ad_4c67_4f1b_9f26_af3560e79b02
name: SLC16A8
type: Species
boundary condition: true
is: O95907
is encoded by: hsa:23539
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR FAOXC204184m
modifier: MODEL1310110024#
reversible: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 rounds of beta ox c20:4 -> c18:4 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
name: Beta oxidation fatty acid
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
type: Reaction
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.3.8.1

metaR APOC LYS BTNPm
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110024#
fast: false
name: proteolysis of apoC-Lys-btn, mitochondrial
is described by: ECO:0000000
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reversible: false
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_3c505226_6c91_494c_bc5a_6859c02ddebc
initial amount: NaN
type: Species
is encoded by: hsa:55500
is: SBO:0000252
boundary condition: true
is: Q9HBU6
initial concentration: NaN
name: ETNK1
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_8a112f97_9014_42f6_add3_57f1ba9b327f
is: O95299
initial amount: NaN
name: NDUFA10
initial concentration: NaN
is encoded by: hsa:4705
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
type: Species

metaR EX gluala LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5-L-Glutamyl-L-alanine exchange
type: Reaction

metaR EX HC02205 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_metaR_EX_s2l2fn2m2masn_LPAREN_e_RPAREN_
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: PA6 exchange
type: Reaction

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

metaM 3hibutcoa m
initial amount: NaN
is: SBO:0000247
name: (S)-3-Hydroxyisobutyryl-CoA
type: Species
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
constant: false
initial concentration: 1.0
is: CHEBI:28259
boundary condition: false
is: HMDB01052
has only substance units: false

metaM 5adtststerones e
has only substance units: false
type: Species
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
is: SBO:0000247
constant: false
is: HMDB06278
boundary condition: false
name: 5alpha-Dihydrotestosterone sulfate
initial concentration: 1.0
initial amount: NaN

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

metaR LNELDCCPT2
modifier: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
product: MODEL1310110024#
kinetic law: MODEL1310110024#
is: SBO:0000176
name: carnitine transferase

http://identifiers.org/biomodels.db/MODEL1310110024#_0ab1d1e1_ab39_4557_8d22_1c7508ef13a9
constant: false
name: ALDH2
is encoded by: hsa:217
boundary condition: true
initial amount: NaN
has only substance units: false
is: P05091
type: Species
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110024#_725b7263_db20_4bb1_9e46_b88656898078
name: PDE8B
is: O95263
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:8622
has only substance units: false
boundary condition: true

metaR FTCD
type: Reaction
modifier: MODEL1310110024#
name: formimidoyltransferase cyclodeaminase
is described by: ECO:0000134
product: MODEL1310110024#
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.1.2.5
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Folate metabolism EC Number: 4.3.1.4 Confidence Level: 4 AUTHORS: PMID:14697341 NOTES:IT
reversible: false
fast: false
reactant: MODEL1310110024#
is: SBO:0000176

metaR r0560
reversible: false
kinetic law: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:
reactant: MODEL1310110024#
type: Reaction
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110024#

metaR r0774
product: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
is: SBO:0000176
modifier: MODEL1310110024#
fast: false
reversible: true
reactant: MODEL1310110024#
is described by: ECO:0000000
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/4.2.1.107

http://identifiers.org/biomodels.db/MODEL1310110024#_567da05f_35ef_417d_b7cb_c6e76f4f5e21
constant: false
boundary condition: true
name: HAGHL
is: SBO:0000252
is encoded by: hsa:84264
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN

metaR FAOXC143C123m
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:3-->C12:3)m
type: Reaction

metaR GGH 10FTHF6GLUe
is: SBO:0000176
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
reversible: false
name: Gamma-glutamyl hydrolase (10FTHF6GLU), extracellular
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
product: MODEL1310110024#
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.4.19.9
is described by: ECO:0000000

metaM hexe3coa m
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: 3-hexenoylcoa
is: HMDB06522
type: Species
is: SBO:0000247
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
constant: false
initial amount: NaN

metaM xoldioloneh c
has only substance units: false
name: 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one
type: Species
initial amount: NaN
is: HMDB06887
constant: false
is: CHEBI:2288
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-18,20-25,29-30H,6-15H2,1-5H3/t17-,18+,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01462 EHMN_ABBREVIATION: C05453
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110024#_daec2955_3b44_438b_bad8_4cbb0390dde8
type: Species
has only substance units: false
constant: false
name: ALPPL2
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:251
initial concentration: NaN
is: P10696

metaR NACHEX18ly
is described by: ECO:0000000
fast: false
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110024#
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110024#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR FAOXC81C61x
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)x
type: Reaction

metaR r0892
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110024#
is: SBO:0000185
fast: false
product: MODEL1310110024#
name: Facilitated diffusion
type: Reaction
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.1.2.27

metaM dadp m
boundary condition: false
has only substance units: false
is: HMDB01508
is: CHEBI:57667
is: SBO:0000247
constant: false
initial concentration: 1.0
name: dADP(3-)
initial amount: NaN
type: Species
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206

http://identifiers.org/biomodels.db/MODEL1310110024#_97830fe0_ac47_481a_a0fe_bf3d52cc2050
type: Species
constant: false
initial amount: NaN
is: P16260
is encoded by: hsa:8034
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
name: SLC25A16

metaM 2dp6mep m
constant: false
name: 2-Decaprenyl-6-methoxyphenol
notes: FORMULA: C57H88O2 CHARGE: 0 INCHI: InChI=1S/C57H88O2/c1-45(2)23-13-24-46(3)25-14-26-47(4)27-15-28-48(5)29-16-30-49(6)31-17-32-50(7)33-18-34-51(8)35-19-36-52(9)37-20-38-53(10)39-21-40-54(11)43-44-55-41-22-42-56(59-12)57(55)58/h22-23,25,27,29,31,33,35,37,39,41-43,58H,13-21,24,26,28,30,32,34,36,38,40,44H2,1-12H3/b46-25+,47-27+,48-29+,49-31+,50-33+,51-35+,52-37+,53-39+,54-43+
is: CHEBI:50774
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_e994bd4b_0ef2_4be4_8d6f_f95cf454fb55
boundary condition: true
is: Q3KQV9
initial amount: NaN
is encoded by: hsa:91373
name: UAP1L1
has only substance units: false
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN

metaM thcholstoic c
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
type: Species
has only substance units: false
is: HMDB03873
is: SBO:0000247
is: CHEBI:18402

http://identifiers.org/biomodels.db/MODEL1310110024#_fb433272_a97f_4a2b_97b8_ecf1aa436591
initial amount: NaN
name: _X63359_1_c
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:X63359
boundary condition: true

metaR PI45PLC
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false
is described by: ECO:0000000
name: phosphatidylinositol 4,5-bisphosphate phospholipase C
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
reversible: false
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.1.4.11
type: Reaction
product: MODEL1310110024#
is: SBO:0000176

metaM s2l2n2m2masn l
is: CHEBI:18287
notes: FORMULA: C84H135N6O61X CHARGE: -2
is: HMDB00174
initial concentration: 1.0
name: de-Fuc form of PA6
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
constant: false

metaR NADPtru
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: false
fast: false
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
name: NADP transporter, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
product: MODEL1310110024#

metaM co2 c
is: CHEBI:3313
name: CO2
notes: FORMULA: CO2 CHARGE: 0
constant: false
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
is: C00011
is: HMDB01967
is: SBO:0000247
initial concentration: 1.0

metaM cmp c
is: C00055
constant: false
is: HMDB00095
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: CHEBI:60377
name: CMP
is: SBO:0000247
initial concentration: 1.0

metaM 5adtststerones c
boundary condition: false
type: Species
constant: false
initial amount: NaN
is: HMDB06278
is: SBO:0000247
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
name: 5alpha-Dihydrotestosterone sulfate
has only substance units: false
initial concentration: 1.0

metaR DESAT22 1p
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
fast: false
product: MODEL1310110024#
is: SBO:0000176
reversible: false
reactant: MODEL1310110024#
name: fatty acyl-CoA desaturase (n-C22:4CoA -> n-C22:5CoA)

http://identifiers.org/biomodels.db/MODEL1310110024#_91e1211d_74bd_4d2d_9151_7669a8246ce4
constant: false
is encoded by: hsa:197257
is: SBO:0000252
is: Q86WU2
has only substance units: false
initial concentration: NaN
type: Species
name: LDHD
boundary condition: true
initial amount: NaN

metaM dadp n
boundary condition: false
is: HMDB01508
is: CHEBI:57667
initial concentration: 1.0
name: dADP(3-)
has only substance units: false
constant: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: SBO:0000247
type: Species
initial amount: NaN

metaR EX 34dhoxpeg LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3,4-Dihydroxyphenylethyleneglycol exchange
type: Reaction

metaM HC01403 m
name: (S)-Hydroxydecanoyl-CoA
initial concentration: 1.0
is: CHEBI:28325
type: Species
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false

metaR r1292
is described by: ECO:0000000
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
is: SBO:0000185
product: MODEL1310110024#
type: Reaction
reversible: true
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
fast: false

metaM ala B c
name: beta-alanine
constant: false
initial amount: NaN
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:16958
is: HMDB00056

metaR CYTDK2m
fast: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
product: MODEL1310110024#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110024#
name: cytidine kinase (ATP), mitochondrial
reactant: MODEL1310110024#

metaR EX pchol hs LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphatidylcholine (homo sapiens) exchange
type: Reaction

metaR CYSGLYexR
name: L-cysteine/glycine reversible exchanger
fast: false
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
type: Reaction
reversible: true
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT

metaM ksi deg3 l
initial amount: NaN
is: CHEBI:50570
type: Species
constant: false
name: keratan sulfate I, degradation product 3
initial concentration: 1.0
notes: FORMULA: C233H371N16O205S12 CHARGE: -13
is: HMDB06529
is: SBO:0000247
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_99e1729f_b64e_46c0_a3dc_c59bbf2d0c68
has only substance units: false
initial amount: NaN
is encoded by: hsa:5151
is: SBO:0000252
type: Species
constant: false
is: H0YMZ7
initial concentration: NaN
name: PDE8A
boundary condition: true

metaR TYRCBOX
is: SBO:0000176
kinetic law: MODEL1310110024#
fast: false
type: Reaction
name: L-Tyrosine carboxy-lyase
is version of: http://identifiers.org/ec-code/4.1.1.28
reversible: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
modifier: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#

metaM udpglcur r
is: C00167
is: CHEBI:58052
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB00935
name: UDP-D-glucuronate
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_1dd786d3_a13d_490d_aea3_60fcd05b456d
initial amount: NaN
name: GGT5
has only substance units: false
is: P36269
initial concentration: NaN
is encoded by: hsa:2687
type: Species
constant: false
is: SBO:0000252
boundary condition: true

metaR r1291
is: SBO:0000185
name: Postulated transport reaction
product: MODEL1310110024#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_de46d72b_e7b5_48d2_aa14_2905c0f25b01
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:W87865
type: Species
name: _W87865_1_c
constant: false
is: SBO:0000252
has only substance units: false

metaR FACOAL206
reactant: MODEL1310110024#
is: SBO:0000176
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110024#
fast: false
modifier: MODEL1310110024#
is described by: ECO:0000269
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
reversible: true
product: MODEL1310110024#

metaM glx c
is: HMDB00119
name: glyoxylate
is: CHEBI:36655
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false

metaR EX udp LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_e332197b_931b_4678_93e0_2684e208a4dd
boundary condition: true
constant: false
is: Q9BW60
initial amount: NaN
is encoded by: hsa:64834
name: ELOVL1
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaR PRASCS
is version of: http://identifiers.org/ec-code/6.3.2.6
modifier: MODEL1310110024#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110024#
reversible: true
reactant: MODEL1310110024#
is: SBO:0000176
fast: false
product: MODEL1310110024#
name: phosphoribosylaminoimidazolesuccinocarboxamide synthase
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR EX 5mta LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-S-methyl-5-thioadenosine
type: Reaction

metaR M1316Mg
notes: GENE_ASSOCIATION: (4124.1) or (4122.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.114 Confidence Level: 0 AUTHORS: PMID:8524845 NOTES:NCD
type: Reaction
fast: false
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
product: MODEL1310110024#
name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.114
is: SBO:0000176
reversible: false
modifier: MODEL1310110024#

metaM tmndnccoa m
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
is: HMDB06514
is: SBO:0000247
constant: false
has only substance units: false
name: timnodonyl coenzyme A
initial amount: NaN

metaM core2 g
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:15876
name: Core 2
initial amount: NaN
notes: FORMULA: C22H37N2O15X CHARGE: 0
constant: false

metaR XYLK
type: Reaction
fast: false
name: xylulokinase
product: MODEL1310110024#
is: SBO:0000176
reactant: MODEL1310110024#
modifier: MODEL1310110024#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.17
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (9942.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.7.1.17 Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269

metaM ala B e
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
name: beta-alanine
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB00056
is: CHEBI:16958
constant: false
initial amount: NaN
has only substance units: false

metaM 44mzym r
is: SBO:0000247
boundary condition: false
is: CHEBI:18364
initial concentration: 1.0
is: HMDB01286
initial amount: NaN
type: Species
name: 14-demethyllanosterol
has only substance units: false
constant: false
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108

metaR FACOAL205
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
fast: false
reversible: true
name: fatty-acid--CoA ligase
is: SBO:0000176
modifier: MODEL1310110024#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110024#
kinetic law: MODEL1310110024#
type: Reaction
reactant: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_1984b534_2b42_4238_9989_3d8150ef12be
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:26
type: Species
is: P19801
name: ABP1
constant: false
initial concentration: NaN

metaM galside hs l
constant: false
has only substance units: false
boundary condition: false
name: D-galactosyl-N-acylsphingosine
is: CHEBI:12947
initial amount: NaN
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
type: Species
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110024#_bf2a033e_42b8_4999_a796_88a989e81f28
is: Q8IWU9
is: SBO:0000252
is encoded by: hsa:121278
type: Species
name: TPH2
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false

metaR ACALDt
reactant: MODEL1310110024#
product: MODEL1310110024#
is: SBO:0000185
reversible: true
fast: false
kinetic law: MODEL1310110024#
type: Reaction
name: acetaldehyde reversible transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaR GTHDH
fast: false
kinetic law: MODEL1310110024#
reversible: false
reactant: MODEL1310110024#
is described by: ECO:0000134
product: MODEL1310110024#
is: SBO:0000176
type: Reaction
name: Glutathione dehydrogenase (dehydroascorbate reductase)
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15970797,PMID:16399380 NOTES:NCD. activity catalyzed by GSTO2-2

http://identifiers.org/biomodels.db/MODEL1310110024#_38104765_8ac6_4e79_a3db_1bfbdb124943
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:H77542
name: _H77542_1_c
type: Species
boundary condition: true
constant: false
initial amount: NaN

metaM h r
is: http://identifiers.org/pubchem.compound/3380
is: CHEBI:24636
name: proton
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: C00080
type: Species
boundary condition: false
initial concentration: 1.0

metaR RE1519M
is: SBO:0000176
type: Reaction
reactant: MODEL1310110024#
modifier: MODEL1310110024#
fast: false
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.3.99.13
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/1.3.3.6
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
kinetic law: MODEL1310110024#
name: RE1519

http://identifiers.org/biomodels.db/MODEL1310110024#_715cd351_6645_4d4e_aabb_82a75298c750
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is: P55084
initial amount: NaN
is encoded by: hsa:3032
name: HADHB

http://identifiers.org/biomodels.db/MODEL1310110024#_e3c3550b_f97b_4345_94d1_e927f5230220
is encoded by: hsa:10201
has only substance units: false
boundary condition: true
constant: false
name: NME6
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
is: O75414

metaR FACOAL204
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT
modifier: MODEL1310110024#
reactant: MODEL1310110024#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase
is described by: ECO:0000269
type: Reaction
reversible: true
product: MODEL1310110024#

metaR DCSPTN1CPT1
reactant: MODEL1310110024#
fast: false
modifier: MODEL1310110024#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
is described by: ECO:0000269
product: MODEL1310110024#
is: SBO:0000176
name: carnitine O-palmitoyltransferase
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ

metaR CYTK9n
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
reversible: true
reactant: MODEL1310110024#
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
name: cytidylate kinase (CMP,dCTP),nuclear

metaM ac m
boundary condition: false
is: CHEBI:30089
name: acetate
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
is: HMDB00042
has only substance units: false

metaR RE3074X
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (11001.1) or (2182.1) or (2181.1) or (2180.1) or (51703.1) or (23305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:11060359,PMID:11356164 NOTES:IT - fixed proton
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
name: RE3074
kinetic law: MODEL1310110024#
product: MODEL1310110024#
fast: false
reactant: MODEL1310110024#
modifier: MODEL1310110024#
is described by: ECO:0000000

metaM galside hs c
initial concentration: 1.0
name: D-galactosyl-N-acylsphingosine
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
initial amount: NaN
is: CHEBI:12947
boundary condition: false
has only substance units: false
type: Species
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110024#_07bb2855_4451_4cfd_a8a4_0b268e39591f
name: HMGCL
initial amount: NaN
is: Q6IBC0
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:3155
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_c4efe26d_c764_4410_94b3_898e53b05982
name: RDH14
is: SBO:0000252
type: Species
has only substance units: false
is: Q9HBH5
is encoded by: hsa:57665
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN

metaR RETFA
reversible: false
product: MODEL1310110024#
is described by: ECO:0000000
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 2.3.1.76 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
kinetic law: MODEL1310110024#
is: SBO:0000176
name: retinol acyltransferase
fast: false
type: Reaction

metaM 4hbzcoa m
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB06467
is: SBO:0000247
initial amount: NaN
name: 4-hydroxybenoyl-CoA
type: Species
notes: FORMULA: C28H36N7O18P3S CHARGE: -4 INCHI: InChI=1/C28H40N7O18P3S/c1-28(2,22(39)25(40)31-8-7-18(37)30-9-10-57-27(41)15-3-5-16(36)6-4-15)12-50-56(47,48)53-55(45,46)49-11-17-21(52-54(42,43)44)20(38)26(51-17)35-14-34-19-23(29)32-13-33-24(19)35/h3-6,13-14,17,20-22,26,36,38-39H,7-12H2,1-2H3,(H,30,37)(H,31,40)(H,45,46)(H,47,48)(H2,29,32,33)(H2,42,43,44)/t17-,20?,21-,22+,26-/m1/s1

metaR S2TASE3ly
is: SBO:0000176
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (3423.2) or (3423.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
type: Reaction
is described by: ECO:0000000
name: iduronate-2-sulfatase, lysosomal
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.13
reversible: false
modifier: MODEL1310110024#

metaR GMPR
product: MODEL1310110024#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110024#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110024#
reversible: false
reactant: MODEL1310110024#
name: GMP reductase
is version of: http://identifiers.org/ec-code/1.7.1.7
notes: GENE_ASSOCIATION: (2766.1) or (51292.1) or (51292.3) or (51292.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.1.7 Confidence Level: 4 AUTHORS: PMID:12009299,PMID:8188226 NOTES:

metaM s2l2n2m2masn e
name: de-Fuc form of PA6
is: SBO:0000247
constant: false
is: HMDB00244
initial concentration: 1.0
notes: FORMULA: C84H135N6O61X CHARGE: -2
initial amount: NaN
is: C00255
boundary condition: false
is: CHEBI:3554
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_72111f6b_ac08_440f_b7f8_da80b9209909
name: NANS
boundary condition: true
initial concentration: NaN
is: Q9NR45
is: SBO:0000252
type: Species
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:54187

metaR MALTSULtm
is described by: ECO:0000269
modifier: MODEL1310110024#
fast: false
reactant: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
name: Malate:thiosulfate antiport, mitochondrial
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reversible: true
kinetic law: MODEL1310110024#
is: SBO:0000185

metaR LTD4DP
fast: false
reactant: MODEL1310110024#
is: SBO:0000176
type: Reaction
product: MODEL1310110024#
name: Leukotriene D4 dipeptidase
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
kinetic law: MODEL1310110024#

metaM thcholstoic m
boundary condition: false
has only substance units: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB03873
type: Species
is: CHEBI:18402

metaM 2hb c
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
initial amount: NaN
is: HMDB00008
is: SBO:0000247
is: CHEBI:1148
type: Species
constant: false
name: 2-Hydroxybutyrate

metaR NRPPHRtu
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110024#
is: SBO:0000185
fast: false
name: Norepinephrine uniport
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
reversible: true
product: MODEL1310110024#
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#

metaM xol7ah2al c
has only substance units: false
is: HMDB06894
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
is: CHEBI:27428
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110024#_f3236218_a9a9_48fb_b74d_25eedb8d4918
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
name: _U37519_1_m
is: SBO:0000252
is encoded by: hsa:U37519

http://identifiers.org/biomodels.db/MODEL1310110024#_f0bd41c6_0bed_4a1a_bd2b_f489dc38dfe7
has only substance units: false
initial amount: NaN
is encoded by: hsa:1384
name: CRAT
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252

metaM dctp n
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:16311
is: HMDB00998
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
constant: false
is: C00458
name: dCTP

http://identifiers.org/biomodels.db/MODEL1310110024#_d2c06a02_4db0_43fd_b30d_9ba81deea275
initial amount: NaN
name: PKM2
type: Species
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:5315
initial concentration: NaN
has only substance units: false
is: P14618

metaR r0899
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
reactant: MODEL1310110024#
is: SBO:0000185
product: MODEL1310110024#
reversible: true
is described by: ECO:0000000
name: Amino acid transporter ATB0+ Facilitated diffusion
kinetic law: MODEL1310110024#

metaR FAOXC1811601m
kinetic law: MODEL1310110024#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110024#
reactant: MODEL1310110024#
name: Beta oxidation fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
reversible: false

metaM 2decdicoa x
initial concentration: 1.0
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
constant: false
name: 2,7-decadienoylcoa
type: Species
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966
is: SBO:0000247
boundary condition: false

metaR FACOAL191
kinetic law: MODEL1310110024#
type: Reaction
name: fatty-acid--CoA ligase
modifier: MODEL1310110024#
is described by: ECO:0000269
reversible: false
fast: false
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:11591435 NOTES:current models suggest COAL activity occurs on outer peroxisomal membrane NJ
is: SBO:0000176
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/6.2.1.3

metaM 2dp6mobq m
is: CHEBI:50773
boundary condition: false
notes: FORMULA: C57H86O3 CHARGE: 0 INCHI: InChI=1S/C57H86O3/c1-44(2)22-13-23-45(3)24-14-25-46(4)26-15-27-47(5)28-16-29-48(6)30-17-31-49(7)32-18-33-50(8)34-19-35-51(9)36-20-37-52(10)38-21-39-53(11)40-41-54-42-55(58)43-56(60-12)57(54)59/h22,24,26,28,30,32,34,36,38,40,42-43H,13-21,23,25,27,29,31,33,35,37,39,41H2,1-12H3/b45-24+,46-26+,47-28+,48-30+,49-32+,50-34+,51-36+,52-38+,53-40+
initial amount: NaN
name: 2-decaprenyl-6-methoxy-1,4-benzoquinone
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
constant: false

metaM 2hb e
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00008
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:1148
type: Species
name: 2-Hydroxybutyrate

metaR UMPK2n
product: MODEL1310110024#
reactant: MODEL1310110024#
is: SBO:0000176
reversible: true
is described by: ECO:0000269
name: UMP kinase (CTP),nuclear
type: Reaction
fast: false
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110024#

metaM ksi pre31 g
is: C00130
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C227H363N16O189S9X CHARGE: -10
is: HMDB00175
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 31
constant: false
has only substance units: false
type: Species
is: CHEBI:58053

metaR ADEt
reactant: MODEL1310110024#
modifier: MODEL1310110024#
reversible: true
fast: false
type: Reaction
is described by: ECO:0000269
name: adenine reversible transport, cytosol
is: SBO:0000185
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD
product: MODEL1310110024#

metaM succ x
initial concentration: 1.0
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
has only substance units: false
boundary condition: false
name: Succinate
type: Species
constant: false
is: HMDB00254
is: CHEBI:30031
is: C00042
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_5fc36d25_8904_4629_9c83_71b190c36c55
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: O43570
name: CA12
is encoded by: hsa:771
constant: false
boundary condition: true
initial concentration: NaN
type: Species

metaR EX akg LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Oxoglutarate exchange
type: Reaction

metaR TCYNTtm
name: Thiocyanate transport via diffusion (mitochondrial)
is described by: ECO:0000000
product: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110024#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM

http://identifiers.org/biomodels.db/MODEL1310110024#_74405241_318b_480c_8758_6d33cdd21c57
initial amount: NaN
is encoded by: hsa:M68895
initial concentration: NaN
is: SBO:0000252
name: _M68895_1_c
has only substance units: false
boundary condition: true
constant: false
type: Species

metaM prostgh2 r
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
is: CHEBI:57405
initial amount: NaN
initial concentration: 1.0
is: HMDB01381
is: SBO:0000247
name: prostaglandin H2(1-)
type: Species
constant: false
has only substance units: false
boundary condition: false

metaM 4hoxpacd c
initial amount: NaN
notes: FORMULA: C8H8O2 CHARGE: 0 INCHI: InChI=1S/C8H8O2/c9-6-5-7-1-3-8(10)4-2-7/h1-4,6,10H,5H2 EHMN_ABBREVIATION: C03765
is: CHEBI:15621
boundary condition: false
name: (4-hydroxyphenyl)acetaldehyde
has only substance units: false
is: HMDB03767
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_4b625b55_33ec_4e5b_bba1_2d971a538380
has only substance units: false
name: SLC26A6
initial concentration: NaN
is encoded by: hsa:65010
constant: false
type: Species
is: Q548A7
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR FADtru
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
name: FAD transporter, endoplasmic reticulum
product: MODEL1310110024#
is: SBO:0000185
fast: false
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110024#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_327627cc_73ed_492b_b7cc_8c3ebb5f94b2
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:23057
constant: false
has only substance units: false
name: NMNAT2
is: SBO:0000252

metaM galside hs g
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
initial concentration: 1.0
constant: false
is: CHEBI:12947
type: Species
name: D-galactosyl-N-acylsphingosine

metaR RE3245C
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
fast: false
product: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton
is described by: ECO:0000000
name: RE3245
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110024#_00ddcfb5_bd5d_4a22_9b10_e13703ac8eff
is encoded by: hsa:84720
name: PIGF:PIGO
type: Species
is encoded by: hsa:5281
initial amount: NaN
is: SBO:0000297
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
has part: Q6IB04

http://identifiers.org/biomodels.db/MODEL1310110024#_2ed53543_ecf9_40e3_9267_2ee256a1f61a
name: MYO5B
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:4645
is: Q9H6Y6
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_5903ee7a_f076_41ff_b033_2b7154e68d61
boundary condition: true
is: Q67FW5
initial concentration: NaN
type: Species
has only substance units: false
name: B3GNTL1
is encoded by: hsa:146712
is: SBO:0000252
initial amount: NaN
constant: false

metaR r2004
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
modifier: MODEL1310110024#
type: Reaction
product: MODEL1310110024#
reversible: false
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaM e4hglu m
is: SBO:0000247
name: erythro-4-hydroxy-L-glutamate(1-)
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947
is: CHEBI:6331
type: Species
is: HMDB02273
initial concentration: 1.0
constant: false

metaR It
fast: false
reactant: MODEL1310110024#
modifier: MODEL1310110024#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reversible: true
is: SBO:0000185
type: Reaction
name: Iodide uniport

metaM ocdca e
initial amount: NaN
boundary condition: false
is: C01530
constant: false
initial concentration: 1.0
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
name: octadecanoate (n-C18:0)
is: SBO:0000247
type: Species
is: HMDB00827
is: CHEBI:25629
has only substance units: false

metaM C04849 e
boundary condition: false
is: CHEBI:57449
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
has only substance units: false

metaM b2coa m
is: HMDB02009
is: SBO:0000247
is: CHEBI:57332
constant: false
initial amount: NaN
type: Species
has only substance units: false
name: crotonoyl-CoA(4-)
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877

metaM malthp e
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
is: http://identifiers.org/pubchem.compound/5041
has only substance units: false
name: maltoheptaose
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: C01936

http://identifiers.org/biomodels.db/MODEL1310110024#_e3bdec54_78af_448f_ae24_1f8e4a98b7df
initial amount: NaN
is: SBO:0000252
type: Species
name: RHAG
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:6005
is: Q96E98

metaR ACOAD1fm
name: acyl-CoA dehydrogenase (butanoyl-CoA), mitochondrial
notes: GENE_ASSOCIATION: (80724.1) or (36.1) or (35.1) or (34.1) or (84129.1) or (27034.1) or (28976.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.3.99.2 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:Assume NAD/NADH as acceptors Lumped long-chain acyl-CoA dehydrogenase (EC 1.3.99.13) This reaction is therefore equilivalent to trans-2-enoyl-CoA reductase (NAD) (EC 1.3.1.44)
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false
product: MODEL1310110024#
type: Reaction
reversible: false

metaR EX dmhptcrn LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2,6 dimethylheptanoyl carnitine exchange
type: Reaction

metaM ksi deg15 l
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
name: keratan sulfate I, degradation product 15
notes: FORMULA: C160H257N11O140S8 CHARGE: -8
boundary condition: false
is: HMDB00143
initial amount: NaN
is: SBO:0000247
is: CHEBI:12936

http://identifiers.org/biomodels.db/MODEL1310110024#_44866161_6202_46fb_bf80_a3c1b8f53545
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110024#_967107b9_e225_470c_aa37_6aa6c3e06eff
type: Species
has only substance units: false
is encoded by: hsa:5096
is: P05166
boundary condition: true
name: PCCB
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110024#_6e08b08e_5905_437a_915e_646809a8c75c
is: C9JFZ1
is: SBO:0000252
has only substance units: false
is encoded by: hsa:8867
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
name: SYNJ1

metaM galside hs e
boundary condition: false
has only substance units: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: D-galactosyl-N-acylsphingosine
is: CHEBI:12947
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_939e385d_2040_434a_9c6b_ef662bce6a1f
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

metaR r2439
reactant: MODEL1310110024#
fast: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: Zinc (Zn2+)-Iron (Fe2+) Permease (ZIP), TCDB:2.A.53.2.2
product: MODEL1310110024#
kinetic law: MODEL1310110024#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12759755 NOTES:

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

metaR r0779
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110024#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110024#
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
modifier: MODEL1310110024#
type: Reaction
kinetic law: MODEL1310110024#
fast: false
reversible: false

metaM hs deg1 l
constant: false
name: heparan sulfate, degradation product 1
boundary condition: false
has only substance units: false
notes: FORMULA: C79H115N5O99S11 CHARGE: -12
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17180
is: HMDB01352
initial amount: NaN

metaR 5ADTSTSTERONEte
fast: false
product: MODEL1310110024#
is described by: ECO:0000000
name: 5 alpha dihydrotesterone transport
type: Reaction
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reversible: true
kinetic law: MODEL1310110024#
is: SBO:0000185

metaM hs deg4 l
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C73H104N4O92S10 CHARGE: -12
is: SBO:0000247
constant: false
name: heparan sulfate, degradation product 4
has only substance units: false
is: CHEBI:16126
type: Species

metaM ksi pre27 g
notes: FORMULA: C205H328N14O171S8X CHARGE: -9
name: keratan sulfate I biosynthesis, precursor 27
is: C00130
type: Species
constant: false
initial amount: NaN
is: CHEBI:58053
boundary condition: false
has only substance units: false
is: HMDB00175
initial concentration: 1.0
is: SBO:0000247

metaR BTNPLm
fast: false
is version of: http://identifiers.org/ec-code/6.3.4.10
is: SBO:0000176
reversible: false
name: holocarboxylase synthestase (biotin protein ligase), mitochondrial
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
reactant: MODEL1310110024#
modifier: MODEL1310110024#
product: MODEL1310110024#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110024#

metaM andrstrn r
is: SBO:0000247
name: androsterone
initial concentration: 1.0
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
is: HMDB00031
is: CHEBI:16032
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_feb7f8b8_2c9a_4206_9e3b_e43c3713fda9
initial amount: NaN
has only substance units: false
constant: false
name: ST20
is: SBO:0000252
type: Species
is: Q9HBF5
boundary condition: true
is encoded by: hsa:400410
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_85bade22_9815_4778_af77_bc4b6e3870e5
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
name: ADHFE1
initial amount: NaN
is encoded by: hsa:137872
is: Q8IWW8
is: SBO:0000252
type: Species

metaM 5aop c
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
is: HMDB01149
is: CHEBI:17549
initial concentration: 1.0
name: 5-Amino-4-oxopentanoate
is: C00430
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
constant: false

metaR PRISTtx
product: MODEL1310110024#
name: prist peroxisomal transport
fast: false
reversible: true
kinetic law: MODEL1310110024#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ
is: SBO:0000185

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_6511e6af_3b88_41c1_b4c0_152a0b6d6721
is: P36542
boundary condition: true
type: Species
is encoded by: hsa:509
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: ATP5C1
initial amount: NaN
constant: false

metaM CE2417 m
type: Species
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
is: HMDB11123
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28387
initial amount: NaN

metaR r0202
type: Reaction
product: MODEL1310110024#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
reversible: true
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
kinetic law: MODEL1310110024#

metaR XOL7AH2tm
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
reversible: true
is described by: ECO:0000000
name: lipid, flip-flop intracellular transport
fast: false
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
type: Reaction
is: SBO:0000185

metaR EX prgstrn LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Progesterone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_9dcf359c_f5fd_4a4a_ba39_1af25b89c802
type: Species
name: SLC25A1
is encoded by: hsa:6576
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: D9HTE9
initial amount: NaN
is: SBO:0000252

metaM co2 r
constant: false
type: Species
boundary condition: false
name: CO2
is: HMDB01967
initial concentration: 1.0
is: C00011
is: SBO:0000247
has only substance units: false
is: CHEBI:16526
initial amount: NaN
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011

http://identifiers.org/biomodels.db/MODEL1310110024#_e23a62a4_8eef_4d1a_af79_0eff18547e79
is: O95497
initial concentration: NaN
constant: false
name: VNN1
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8876

metaR TDCHOLAtx
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
product: MODEL1310110024#
is described by: ECO:0000000
name: bile acid intracellular transport
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
fast: false
is: SBO:0000185
type: Reaction

metaM arachcoa m
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
is: CHEBI:15527
name: arachidyl coenzyme A
type: Species
is: HMDB04258
is: SBO:0000247

metaR CRNCAR3tp
fast: false
reactant: MODEL1310110024#
name: carnitine-propcarnitine carrier, peroxisomal
kinetic law: MODEL1310110024#
product: MODEL1310110024#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:copied from NCD's CRNCARtp NJ

metaR H2Otly
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: H2O transport, lysosomal
fast: false
reversible: true
reactant: MODEL1310110024#
product: MODEL1310110024#
is described by: ECO:0000000

metaR VACCCRNt
type: Reaction
fast: false
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110024#
is described by: ECO:0000269
reversible: false
name: transport into the mitochondria (carnitine)
is: SBO:0000185
product: MODEL1310110024#
reactant: MODEL1310110024#

metaM xol7ah2 m
is: CHEBI:28047
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
is: HMDB06893
constant: false
name: 5beta-cholestane-3alpha,7alpha-diol

http://identifiers.org/biomodels.db/MODEL1310110024#_89b8454e_c9ed_402b_81c6_4aafdea8e0a3
has only substance units: false
constant: false
boundary condition: true
name: COX2
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4513
is: Q7GXZ8

http://identifiers.org/biomodels.db/MODEL1310110024#_81c073b0_507e_4d48_91f5_8944690fc832
type: Species
is: SBO:0000252
constant: false
is: P13196
name: ALAS1
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:211
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_7f0555ec_4ac0_44d1_8854_582916eb191c
initial amount: NaN
is: SBO:0000252
name: PDE7B
is: Q9NP56
boundary condition: true
initial concentration: NaN
is encoded by: hsa:27115
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_fe9ce071_1fa8_4ba7_a4cc_763bd71defd1
is: Q6LEN5
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1103
constant: false
is: SBO:0000252
boundary condition: true
type: Species
name: CHAT
has only substance units: false

metaR AACOAT
reversible: true
name: Acetoacetyl-CoA:acetate CoA-transferase
modifier: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (65985.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.16 Confidence Level: 4 AUTHORS: PMID:12623130 NOTES:also EC 2.8.3.8 NCD
fast: false
kinetic law: MODEL1310110024#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.16
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110024#_b9f8c472_72e7_4a8e_baab_434cbf1b558e
has only substance units: false
is: A8K5J1
is encoded by: hsa:7372
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: UMPS
initial concentration: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_260d7058_e07c_4e35_9671_631d2cbb0f3f
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
is: E7ETH5
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:9058
name: SLC13A2

http://identifiers.org/biomodels.db/MODEL1310110024#_0b7ee09f_8399_4666_9026_786b9cb35c0e
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:4704
constant: false
has only substance units: false
is: SBO:0000252
is: Q16795
name: NDUFA9
initial concentration: NaN

metaM mn l
name: beta-1,4-mannose-N-acetylglucosamine
initial amount: NaN
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB06535
is: SBO:0000247
type: Species
has only substance units: false

metaM val L m
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: CHEBI:16414
is: SBO:0000247
initial amount: NaN
name: L-valine
is: HMDB00883
constant: false

metaR r2119
product: MODEL1310110024#
is: SBO:0000185
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110024#
type: Reaction
reversible: true
fast: false
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110024#

metaR NDP3ex
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:EC is 3.6.1.42? NCD
modifier: MODEL1310110024#
name: nucleoside-diphosphatase (GDP), extracellular
reactant: MODEL1310110024#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.1.6
product: MODEL1310110024#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110024#
fast: false

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

metaM ksii core2 pre5 g
boundary condition: false
has only substance units: false
is: C00130
type: Species
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 5
is: HMDB00175
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:58053
notes: FORMULA: C61H99N5O43X CHARGE: -1

metaR CSPG Atly
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
is described by: ECO:0000000
name: chondroitin sulfate A transport, extracellular to lysosome
is: SBO:0000185
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
fast: false
reversible: false

metaR HACD9m
reversible: true
kinetic law: MODEL1310110024#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110024#
modifier: MODEL1310110024#
fast: false
reactant: MODEL1310110024#
is: SBO:0000176
is described by: ECO:0000134
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid

metaM ocdca c
initial concentration: 1.0
type: Species
is: HMDB00827
has only substance units: false
constant: false
name: stearate
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
is: CHEBI:25629

metaM ca2 c
is: HMDB00464
constant: false
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
is: CHEBI:29108
initial concentration: 1.0
has only substance units: false
name: calcium(2+)
initial amount: NaN

metaR GLCNACASE4ly
is: SBO:0000176
name: alpha-N-acetylglucosaminidase, lysosomal
fast: false
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
product: MODEL1310110024#
reversible: false
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.50
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#

metaR NAIt
is: SBO:0000185
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false
name: Na+ / iodide cotransport
reactant: MODEL1310110024#
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
type: Reaction
reversible: true
is described by: ECO:0000269

metaR r2118
product: MODEL1310110024#
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110024#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110024#
fast: false

metaM pail5p hs c
constant: false
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:57795
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3

http://identifiers.org/biomodels.db/MODEL1310110024#_d175ba54_f6cd_4ede_895b_7536267e9a95
constant: false
is: P24752
is encoded by: hsa:38
has only substance units: false
initial amount: NaN
boundary condition: true
name: ACAT1
is: SBO:0000252
initial concentration: NaN
type: Species

metaM gthrd m
is: HMDB00125
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: CHEBI:57925
type: Species
initial concentration: 1.0
has only substance units: false
name: glutathionate(1-)
initial amount: NaN

metaM ala D c
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB01310
has only substance units: false
is: CHEBI:15570
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
boundary condition: false
constant: false
name: D-alanine

http://identifiers.org/biomodels.db/MODEL1310110024#_b1d8dc31_fbfb_4773_8f21_c2c8374c2f98
is encoded by: hsa:4702
is: SBO:0000252
initial concentration: NaN
constant: false
name: NDUFA8
type: Species
boundary condition: true
is: B1AM93
initial amount: NaN
has only substance units: false

metaM cmp n
is: HMDB00095
boundary condition: false
initial amount: NaN
is: CHEBI:60377
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: SBO:0000247
name: CMP(2-)
initial concentration: 1.0
constant: false
has only substance units: false
type: Species

metaM glc D e
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
name: D-glucose
is: HMDB00122
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
boundary condition: false
type: Species
is: CHEBI:4167

metaM gacpail hs r
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
name: glucosaminyl-acylphosphatidylinositol
has only substance units: false
is: SBO:0000247
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN
is: HMDB00128
is: CHEBI:16344

metaR r2117
is described by: ECO:0000000
reactant: MODEL1310110024#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reversible: true
fast: false
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110024#
kinetic law: MODEL1310110024#

metaR COQ5m
is: SBO:0000176
reactant: MODEL1310110024#
name: Ubiquinone biosynthesis methyltransferase COQ5
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10777520,PMID:1965190,PMID:7380842 NOTES:_2.1.1.- IT
type: Reaction
product: MODEL1310110024#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_b2fc26c0_50c8_4923_b69a_d92d14677611
name: COX4I2
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:84701
type: Species
is: SBO:0000252
constant: false
is: Q96KJ9

metaR RE3626M
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
product: MODEL1310110024#
type: Reaction
reactant: MODEL1310110024#
name: RE3626
reversible: false
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
kinetic law: MODEL1310110024#
is: SBO:0000176
modifier: MODEL1310110024#

metaR r0559
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.3
modifier: MODEL1310110024#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
fast: false
reactant: MODEL1310110024#
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
kinetic law: MODEL1310110024#
reversible: true
product: MODEL1310110024#

metaR DM Ser Thr ly
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser/Thr(ly)
type: Reaction

metaM ksi deg36 l
initial concentration: 1.0
type: Species
boundary condition: false
name: keratan sulfate I, degradation product 36
has only substance units: false
is: HMDB00143
constant: false
is: CHEBI:12936
notes: FORMULA: C62H103N4O49S1 CHARGE: -1
is: SBO:0000247
initial amount: NaN

metaM hexe3coa x
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
boundary condition: false
has only substance units: false
is: HMDB06522
is: SBO:0000247
name: 3-hexenoylcoa
type: Species

metaM succ m
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:30031
name: Succinate
is: C00042
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: SBO:0000247
is: HMDB00254
boundary condition: false

metaM imp e
has only substance units: false
is: HMDB00175
notes: FORMULA: C10H11N4O8P CHARGE: -2 INCHI: InChI=1S/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
name: IMP(2-)
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:58053
initial concentration: 1.0
constant: false
is: SBO:0000247

metaR RE1532M
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000176
type: Reaction
name: RE1532
product: MODEL1310110024#
modifier: MODEL1310110024#
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true

metaR UAGALDP
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110024#
fast: false
type: Reaction
name: UDP-N-acetylgalactosamine diphosphorylase
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
reversible: false

metaM co2 m
is: HMDB01967
constant: false
has only substance units: false
type: Species
initial amount: NaN
name: CO2
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
initial concentration: 1.0
is: SBO:0000247
is: C00011
is: CHEBI:16526
boundary condition: false

metaM cmp m
constant: false
name: CMP(2-)
has only substance units: false
type: Species
is: HMDB00095
initial amount: NaN
is: CHEBI:60377
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110024#_5b60720f_276e_4697_bc5c_e5f4fc1c70bb
is encoded by: hsa:8525
is: SBO:0000252
initial amount: NaN
is: B7Z6M3
type: Species
name: DGKZ
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN

metaM hs deg17 l
boundary condition: false
is: CHEBI:21338
constant: false
type: Species
notes: FORMULA: C43H65N2O48S4 CHARGE: -5
is: HMDB02704
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: heparan sulfate, degradation product 17

metaR ME2m
name: malic enzyme (NADP), mitochondrial
modifier: MODEL1310110024#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.40
product: MODEL1310110024#
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (4200.1) or (10873.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:IF
reactant: MODEL1310110024#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.38
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110024#_ef89015a_f1d9_4a54_b0a7_fdc07dc1cf81
is: SBO:0000252
is: Q16760
name: DGKD
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:8527
initial amount: NaN
type: Species
has only substance units: false

metaR OCTDECCPT1
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

metaR HXPRT
is version of: http://identifiers.org/ec-code/2.4.2.8
name: hypoxanthine phosphoribosyltransferase (Hypoxanthine)
is: SBO:0000176
fast: false
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
product: MODEL1310110024#
is described by: ECO:0000269
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine (see GUAPRT) and 6-mercaptopurine can replace hypoxanthine
reactant: MODEL1310110024#

metaR r0558
reversible: true
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.5.1.3
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
reactant: MODEL1310110024#
type: Reaction
modifier: MODEL1310110024#

metaM ala D e
constant: false
initial amount: NaN
name: D-alanine
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
type: Species
is: CHEBI:15570
boundary condition: false
initial concentration: 1.0
is: HMDB01310
is: SBO:0000247

metaR DAG HSter
type: Reaction
reversible: false
reactant: MODEL1310110024#
fast: false
name: diacylglycerol ER export
product: MODEL1310110024#
kinetic law: MODEL1310110024#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000

metaR MACOXO
reversible: false
reactant: MODEL1310110024#
name: 3-Methylimidazole acetaldehyde:NAD+ oxidoreductase
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (218.1) or (221.1) or (4129.1) or (222.1) or (220.1) SUBSYSTEM: Histidine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10344773 NOTES:SAB added 2 h to balance--not certain
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.4.3.4
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110024#

metaM Lfmkynr c
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: N-formyl-L-kynurenine
notes: FORMULA: C11H12N2O4 CHARGE: 0 INCHI: InChI=1S/C11H12N2O4/c12-8(11(16)17)5-10(15)7-3-1-2-4-9(7)13-6-14/h1-4,6,8H,5,12H2,(H,13,14)(H,16,17)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00985 EHMN_ABBREVIATION: C02700
is: HMDB01200
type: Species
is: CHEBI:30249
constant: false
is: SBO:0000247
has only substance units: false

metaR r2116
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000000
modifier: MODEL1310110024#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
kinetic law: MODEL1310110024#
type: Reaction
is: SBO:0000185
reversible: true

metaM HC00695 m
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
name: S-Succinyldihydrolipoamide
is: CHEBI:17432
initial amount: NaN
boundary condition: false
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
is: SBO:0000247

metaR 5OXPROt
fast: false
type: Reaction
name: Transport of 5-oxoprolinate
kinetic law: MODEL1310110024#
reversible: true
is: SBO:0000185
is described by: ECO:0000134
reactant: MODEL1310110024#
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR 2HBt2
product: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110024#
name: 2-hydroxybutyrate cotransport with proton
type: Reaction
fast: false
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110024#

metaR SERDGLYexR
kinetic law: MODEL1310110024#
name: D-Serine/Glycine reversible exchange
reversible: true
is: SBO:0000185
reactant: MODEL1310110024#
modifier: MODEL1310110024#
fast: false
product: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304

metaR r0400
type: Reaction
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
is version of: http://identifiers.org/ec-code/1.2.4.4
modifier: MODEL1310110024#
reactant: MODEL1310110024#
product: MODEL1310110024#
kinetic law: MODEL1310110024#
is: SBO:0000176
reversible: true
is described by: ECO:0000000
fast: false

metaR OCTDECCPT2
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

metaR ALAt2r
name: L-alanine reversible transport via proton symport
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
is: SBO:0000185
modifier: MODEL1310110024#
is described by: ECO:0000304
fast: false
kinetic law: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
reversible: true

metaR THYOXt
product: MODEL1310110024#
type: Reaction
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
reversible: true
modifier: MODEL1310110024#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (53919.1) or (6579.1) or (28231.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
name: T4 transport via bicarbonate countertransport
is: SBO:0000185

metaR GLNyLATthc
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Glutamine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

metaR r2331
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110024#
fast: false

metaM ksi deg21 l
is: CHEBI:12936
constant: false
type: Species
is: HMDB00143
notes: FORMULA: C132H213N9O114S6 CHARGE: -6
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: keratan sulfate I, degradation product 21
initial amount: NaN

metaM aicar c
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
is: C04677
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
constant: false
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
initial amount: NaN
is: HMDB01517
initial concentration: 1.0
is: CHEBI:58475

metaR r2115
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110024#
type: Reaction
reactant: MODEL1310110024#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_091ac1c9_97f4_44ec_8dfd_0cb9e796b0cb
name: ACADL
is: SBO:0000252
has only substance units: false
boundary condition: true
is: P28330
type: Species
initial concentration: NaN
is encoded by: hsa:33
initial amount: NaN
constant: false

metaM imp c
constant: false
is: SBO:0000247
is: HMDB00175
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
boundary condition: false
type: Species
is: C00130
initial concentration: 1.0
name: IMP
initial amount: NaN
is: CHEBI:58053
has only substance units: false

metaR S3TASE2ly
kinetic law: MODEL1310110024#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
product: MODEL1310110024#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110024#
reversible: true
name: N-acetylglucosamine-3-sulfatase, lysosomal

metaR PHEyLATthc
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Phenylalanine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_d44fe6b2_c344_4f1f_b24d_07047fbe353a
is: O43772
has only substance units: false
boundary condition: true
initial amount: NaN
name: SLC25A20
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:788

metaR RE0958E
is version of: http://identifiers.org/ec-code/3.2.1.1
kinetic law: MODEL1310110024#
fast: false
name: RE0958
reactant: MODEL1310110024#
is: SBO:0000176
is described by: ECO:0000000
reversible: true
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
type: Reaction
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.2.1.17

metaR GPIAT
modifier: MODEL1310110024#
is: SBO:0000176
product: MODEL1310110024#
name: glucosaminylphosphatidyl inositol acetyltransferase
reactant: MODEL1310110024#
fast: false
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (284098.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14517336 NOTES:EC 2.3.-.- NCD
kinetic law: MODEL1310110024#
is described by: ECO:0000269

metaM udpglcur c
constant: false
is: HMDB00935
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
initial amount: NaN
name: UDP-D-glucuronate
is: C00167
is: CHEBI:58052

metaM pe hs m
constant: false
initial amount: NaN
name: phosphatidylethanolamine
is: CHEBI:16038
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110024#_2370e415_cce2_4106_9fe9_c64129f0b18c
is: Q5JT09
has only substance units: false
is encoded by: hsa:83549
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252
name: UCK1

metaR CSEPASEly
is: SBO:0000176
kinetic law: MODEL1310110024#
is described by: ECO:0000000
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
reactant: MODEL1310110024#
reversible: false
name: chondroitin sulfate E proteoglycan protease, lysosome (endosome)
fast: false
type: Reaction

metaR r2330
is described by: ECO:0000000
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
kinetic law: MODEL1310110024#
type: Reaction
product: MODEL1310110024#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
is: SBO:0000185

metaR r2443
is: SBO:0000185
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
fast: false
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110024#
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
is described by: ECO:0000000

metaR ALASERNaEx
fast: false
is: SBO:0000185
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
reversible: false
name: L-alanine/L-serine Na-dependent exchange (Ala-L in)
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
is described by: ECO:0000269

metaR FACOAL184
is described by: ECO:0000000
modifier: MODEL1310110024#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110024#
reactant: MODEL1310110024#
type: Reaction
kinetic law: MODEL1310110024#
name: fatty-acid--CoA ligase
fast: false

metaM lnlncgcrn m
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h9-10,12-13,15-16,23H,5-8,11,14,17-22H2,1-4H3/b10-9-,13-12-,16-15-/t23-/m0/s1
is: SBO:0000247
initial amount: NaN
is: HMDB06318
type: Species
name: gamma-linolenyl carnitine
constant: false

metaM fprica c
is: C04734
is: SBO:0000247
is: CHEBI:58467
type: Species
notes: FORMULA: C10H13N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01344 EHMN_ABBREVIATION: C04734
has only substance units: false
is: HMDB01439
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

metaR r2114
is: SBO:0000185
modifier: MODEL1310110024#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110024#
is described by: ECO:0000000
kinetic law: MODEL1310110024#
fast: false
type: Reaction
reversible: true
product: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_76929fd5_1de1_42ff_b6bc_b26ab0b2ead0
is: Q9H490
boundary condition: true
name: PIGU
constant: false
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:128869

metaR EX gmp LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GMP exchange
type: Reaction

metaR r2113
reversible: true
fast: false
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110024#
product: MODEL1310110024#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction

metaR AG13T1g
modifier: MODEL1310110024#
fast: false
reactant: MODEL1310110024#
is: SBO:0000176
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (374907.2) or (374907.1) or (146712.1) or (10331.1) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false
product: MODEL1310110024#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000

metaM val L c
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: L-valine
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
type: Species
is: CHEBI:16414
boundary condition: false
is: HMDB00883
constant: false

metaR r2333
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
product: MODEL1310110024#
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
reversible: true
is: SBO:0000185

metaM prostgh2 c
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
initial amount: NaN
is: SBO:0000247
is: HMDB01381
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:57405
name: prostaglandin H2(1-)
has only substance units: false
boundary condition: false

metaR SERALANaEx
kinetic law: MODEL1310110024#
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
is: SBO:0000185
reactant: MODEL1310110024#
reversible: false
modifier: MODEL1310110024#
fast: false
is described by: ECO:0000269
name: L-alanine/L-serine Na-dependent exchange (Ser-L in)

http://identifiers.org/biomodels.db/MODEL1310110024#_ffe30380_7eb6_4b60_b030_81ff9733c462
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
is: Q9Y217
boundary condition: true
is encoded by: hsa:9107
has only substance units: false
name: MTMR6
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_5e0625ca_eb07_43ea_b9fe_a3dee77b02da
boundary condition: true
is: G3V0F6
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: DGKZ
type: Species
is encoded by: hsa:8525
initial concentration: NaN
constant: false

metaR r1384
fast: false
name: Guanosine aminohydrolase EC:3.5.4.15
reversible: true
reactant: MODEL1310110024#
is: SBO:0000176
product: MODEL1310110024#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:

metaR GUAt
name: Guanine transport
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR
reactant: MODEL1310110024#
reversible: true
product: MODEL1310110024#
fast: false
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
is described by: ECO:0000269

metaR r2112
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
reactant: MODEL1310110024#
is described by: ECO:0000000
product: MODEL1310110024#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110024#

metaR UMPK
reactant: MODEL1310110024#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110024#
name: UMP kinase
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
is: SBO:0000176

metaM 5aop m
initial amount: NaN
is: HMDB01149
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
is: C00430
name: 5-Amino-4-oxopentanoate
constant: false
type: Species
has only substance units: false
is: CHEBI:17549
initial concentration: 1.0

metaR RTOTALFATPc
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal by enterocytes
type: Reaction

metaR SACCD3m
modifier: MODEL1310110024#
reversible: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.1.8 Confidence Level: 4 AUTHORS: PMID:10775527 NOTES:MM
product: MODEL1310110024#
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
name: saccharopine dehydrogenase (NADP, L-lysine forming), mitochondrial
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.8
is described by: ECO:0000269

metaR r2332
reversible: true
is described by: ECO:0000000
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
kinetic law: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110024#
product: MODEL1310110024#

metaR r0627
type: Reaction
is: SBO:0000176
reactant: MODEL1310110024#
product: MODEL1310110024#
is described by: ECO:0000000
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
fast: false
reversible: true

metaM lnlncgcrn c
boundary condition: false
is: HMDB06318
name: gamma-linolenyl carnitine
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h9-10,12-13,15-16,23H,5-8,11,14,17-22H2,1-4H3/b10-9-,13-12-,16-15-/t23-/m0/s1
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
has only substance units: false

metaR PHYHx
reactant: MODEL1310110024#
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5264.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.14.11.18 Confidence Level: 4 AUTHORS: PMID:8954107,PMID:9326940 NOTES:NJ
reversible: false
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.14.11.18
name: Phytanoyl-CoA dioxygenase, peroxisomal
type: Reaction

metaM pe hs c
has only substance units: false
name: phosphatidylethanolamine
is: SBO:0000247
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:16038

metaM ksi deg20 l
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:12936
is: SBO:0000247
name: keratan sulfate I, degradation product 20
is: HMDB00143
notes: FORMULA: C138H223N9O119S6 CHARGE: -6
initial concentration: 1.0
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_828cc2c1_be04_4910_8df1_fa91a9d3ba0f
constant: false
is: SBO:0000252
initial concentration: NaN
name: SLC4A10
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:57282
is: B7Z1R0
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110024#_eb3493be_c3ad_42aa_a28e_a3772f89f695
has only substance units: false
name: GSR
type: Species
is encoded by: hsa:2936
is: P00390
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110024#_163c382d_db1d_4ea9_baee_180b88da3fb8
is: P42765
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
name: ACAA2
is encoded by: hsa:10449

metaR DRBK
is version of: http://identifiers.org/ec-code/2.7.1.15
product: MODEL1310110024#
is described by: ECO:0000304
reactant: MODEL1310110024#
name: Deoxyribokinase
is: SBO:0000176
notes: GENE_ASSOCIATION: (64080.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.7.1.15 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
fast: false
modifier: MODEL1310110024#
reversible: false
kinetic law: MODEL1310110024#
type: Reaction

metaR PMANM
is version of: http://identifiers.org/ec-code/5.4.2.2
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176
product: MODEL1310110024#
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/5.4.2.8
kinetic law: MODEL1310110024#
is described by: ECO:0000000
name: phosphomannomutase
type: Reaction
reversible: true
fast: false

metaR MGSA
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: 4.2.3.3 Confidence Level: 4 AUTHORS: PMID:1537826,PMID:16037240,PMID:8853285 NOTES:Previously EC 4.2.99.11 this rxn represents the enzymatic conversion or non-enzymatic fragmentation of dhap to mthgxl - NCD
product: MODEL1310110024#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110024#
reversible: false
reactant: MODEL1310110024#
name: methylglyoxal synthase
fast: false

metaR r2111
type: Reaction
reactant: MODEL1310110024#
modifier: MODEL1310110024#
product: MODEL1310110024#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110024#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM val L e
initial concentration: 1.0
boundary condition: false
is: HMDB00883
is: SBO:0000247
constant: false
is: CHEBI:16414
initial amount: NaN
name: L-valine
has only substance units: false
type: Species
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174

metaM tmndnccoa x
is: HMDB06514
is: SBO:0000247
boundary condition: false
name: timnodonyl coenzyme A
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
constant: false
initial concentration: 1.0

metaR r0208
is described by: ECO:0000000
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
product: MODEL1310110024#
type: Reaction
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/4.4.1.1
reactant: MODEL1310110024#
reversible: true
kinetic law: MODEL1310110024#

metaM tdchola x
is: CHEBI:9407
type: Species
initial concentration: 1.0
name: taurochenodeoxycholate
boundary condition: false
is: HMDB00951
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN

metaR r2335
is described by: ECO:0000000
kinetic law: MODEL1310110024#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
product: MODEL1310110024#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110024#_8c5c8ae0_c62f_41bf_9a82_d06baad3f3da
is encoded by: hsa:471
constant: false
type: Species
has only substance units: false
name: ATIC
initial concentration: NaN
is: SBO:0000252
is: P31939
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110024#_3037813a_6922_4d32_bc16_32ffaf22881e
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
is: Q92947
is encoded by: hsa:2639
boundary condition: true
name: GCDH

metaM uri e
name: Uridine
has only substance units: false
is: HMDB00296
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
is: CHEBI:16704
boundary condition: false
is: C00299
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
constant: false

metaR GAPD
modifier: MODEL1310110024#
is: SBO:0000176
product: MODEL1310110024#
name: glyceraldehyde-3-phosphate dehydrogenase
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.
reversible: true
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.2.1.12
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110024#
type: Reaction

metaM arachcoa c
is: HMDB04258
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
is: CHEBI:15527
constant: false
is: SBO:0000247
initial concentration: 1.0
name: arachidyl coenzyme A
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false

metaR METAT
fast: false
reversible: false
modifier: MODEL1310110024#
reactant: MODEL1310110024#
is: SBO:0000176
product: MODEL1310110024#
name: methionine adenosyltransferase
kinetic law: MODEL1310110024#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4143.1) or (27430.2 and 4144.1) or (27430.1 and 4144.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.5.1.6

metaR GHMT2rm
fast: false
is version of: http://identifiers.org/ec-code/2.1.2.1
modifier: MODEL1310110024#
is described by: ECO:0000269
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (6472.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
name: glycine hydroxymethyltransferase, reversible, mitochondrial
is: SBO:0000176
product: MODEL1310110024#
reactant: MODEL1310110024#
reversible: true
type: Reaction

metaM glc D c
initial amount: NaN
type: Species
has only substance units: false
constant: false
name: D-glucose
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
initial concentration: 1.0
is: CHEBI:4167
is: HMDB00122
is: SBO:0000247

metaR r2110
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reversible: true
reactant: MODEL1310110024#
is described by: ECO:0000000
product: MODEL1310110024#
kinetic law: MODEL1310110024#
type: Reaction
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_10d24507_1824_4ff1_9363_faad5de7777f
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:50808
has only substance units: false
type: Species
is: E7ET30
constant: false
name: AK3
is: SBO:0000252

metaM gthrd e
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:57925
is: HMDB00125
name: glutathionate(1-)
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
type: Species
initial concentration: 1.0

metaR r0629
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
is described by: ECO:0000000
fast: false
product: MODEL1310110024#
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.1.4.1
modifier: MODEL1310110024#
reversible: true
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.22
kinetic law: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_acc02093_b0ea_4319_bded_dc35b85fd49f
is encoded by: hsa:55312
is: B2RDZ2
initial concentration: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
name: RFK
initial amount: NaN

metaR r0403
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110024#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110024#
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) Tryptophan metabolism EC:1.14.16.4
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.4 Confidence Level: 0 AUTHORS: NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/1.2.4.4
modifier: MODEL1310110024#

metaR r0556
modifier: MODEL1310110024#
reversible: true
is version of: http://identifiers.org/ec-code/1.14.19.1
reactant: MODEL1310110024#
is: SBO:0000176
is described by: ECO:0000000
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
kinetic law: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
product: MODEL1310110024#
type: Reaction

metaM xylu D c
initial amount: NaN
is: CHEBI:17140
type: Species
is: SBO:0000247
has only substance units: false
name: D-xylulose
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB01644
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m1/s1

metaR r2334
is: SBO:0000185
kinetic law: MODEL1310110024#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
product: MODEL1310110024#
reactant: MODEL1310110024#

metaM 13 cis retn r
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: 13-cis-retinoate
is: HMDB06219
is: D00348
constant: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
is: http://identifiers.org/pubchem.compound/7847414

metaR r1298
product: MODEL1310110024#
is: SBO:0000185
fast: false
type: Reaction
name: Vesicular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#

metaM pristcoa c
is: SBO:0000247
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
boundary condition: false
type: Species
constant: false
has only substance units: false
is: CHEBI:51341
initial concentration: 1.0
initial amount: NaN
name: pristanoyl coa

metaR CYSTLEUrBATtc
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Cystine into the cell in exchange for L-Leucine by b0,+AT transporter at the apical surfaces of the membranes of small intestine and renal cells.
type: Reaction

metaR DHEAtr
type: Reaction
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: 2.8.2.2 Confidence Level: 1 AUTHORS: PMID:11535246,PMID:1588921 NOTES:
name: Dehydroepiandrosterone transport
product: MODEL1310110024#
is: SBO:0000185
reactant: MODEL1310110024#
reversible: true
kinetic law: MODEL1310110024#

metaM malthx e
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
initial amount: NaN
name: Maltohexaose
has only substance units: false
is: http://identifiers.org/pubchem.compound/5041
is: C01936
boundary condition: false
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0

metaM HC10852 r
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
name: palmitoleyl-CoA(4-)
initial amount: NaN
has only substance units: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h9-10,24-26,30-32,36,47-48H,4-8,11-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b10-9-/t26-,30-,31-,32+,36-/m1/s1 EHMN_ABBREVIATION: CE0852
constant: false
is: CHEBI:61540

metaM s2l2n2m2m l
is: HMDB06529
name: de-Fuc form of PA6 (w/o peptide linkage)
has only substance units: false
notes: FORMULA: C84H136N6O62 CHARGE: -2
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
is: CHEBI:50570
is: SBO:0000247
boundary condition: false

metaM ser D c
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
is: CHEBI:16523
constant: false
is: HMDB03406
is: SBO:0000247
name: D-serine
type: Species
has only substance units: false

metaR AMPDA
name: Adenosine monophosphate deaminase
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (271.2) or (270.1) or (271.1) or (272.1) or (271.3) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.6 Confidence Level: 4 AUTHORS: PMID:1400401,PMID:2345176 NOTES:
is: SBO:0000176
product: MODEL1310110024#
is described by: ECO:0000269
modifier: MODEL1310110024#
reactant: MODEL1310110024#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.6
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110024#_cdf77e5f_16f9_4448_852c_f5870608e484
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is: Q16718
is encoded by: hsa:4698
name: NDUFA5
boundary condition: true

metaR r1299
product: MODEL1310110024#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false
name: Vesicular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_da0d8429_6b28_47a0_855e_dfe05ce70f65
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
name: BDH1
constant: false
is: SBO:0000252
is encoded by: hsa:622

http://identifiers.org/biomodels.db/MODEL1310110024#_64985c18_219d_4f6a_995b_e17e151a00cd
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: SLC25A11
type: Species
is: F5GY65
constant: false
initial concentration: NaN
is encoded by: hsa:8402
boundary condition: true

metaM succ e
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB00254
is: CHEBI:30031
initial amount: NaN
has only substance units: false
name: succinate(2-)

metaR FAOXC17C15m
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C17-->C15)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_8b3e7f1c_fb10_420d_b801_6a976243ee2f
name: DHODH
is encoded by: hsa:1723
is: SBO:0000252
type: Species
is: Q02127
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110024#_35e007d8_69d9_4300_9c6f_7d10051af32f
is encoded by: hsa:51
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is: B4DK61
has only substance units: false
constant: false
name: ACOX1

metaR LNLNCGCPT2
name: carnitine transferase
reactant: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
reversible: false
fast: false
product: MODEL1310110024#

metaR r1380
product: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false
is: SBO:0000176
reversible: true
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
type: Reaction
reactant: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_43c9a842_3d29_4fc5_bf1e_49063aeaceb7
initial concentration: NaN
name: GNS
is encoded by: hsa:2799
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
is: Q7Z3X3

metaR DLNLCGt
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is: SBO:0000185
product: MODEL1310110024#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110024#_d38416e1_e1ea_4b14_94ea_7fb4e4a1a713
is: O14975
constant: false
is encoded by: hsa:11001
is: SBO:0000252
name: SLC27A2
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true

metaR DGAT
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.20
fast: false
notes: GENE_ASSOCIATION: (8694.1) or (84649.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11481335 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
name: diacylglycerol acyltransferase
reactant: MODEL1310110024#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
is: SBO:0000176
product: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_8b13a491_bdbd_4150_837e_3c630ac3aa26
boundary condition: true
is: SBO:0000252
is: O00154
constant: false
initial amount: NaN
type: Species
has only substance units: false
name: ACOT7
is encoded by: hsa:11332
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_2b5cbb03_b85d_4b0c_8565_84f5c04be818
initial amount: NaN
type: Species
name: PIGO
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:84720

metaM gthrd c
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:57925
is: C00051
is: HMDB00125
constant: false
initial concentration: 1.0
name: Reduced glutathione
is: SBO:0000247
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
has only substance units: false

metaR GALASE10ly
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110024#
reversible: false
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110024#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4

http://identifiers.org/biomodels.db/MODEL1310110024#_129c733b_bf2d_412d_90ef_99a9c6d4f639
is encoded by: hsa:3636
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: INPPL1
is: O15357
constant: false

metaM co2 e
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: CHEBI:16526
constant: false
is: SBO:0000247
is: HMDB01967
boundary condition: false
has only substance units: false
type: Species
name: CO2
initial amount: NaN
initial concentration: 1.0
is: C00011

metaM cmp e
name: CMP(2-)
is: CHEBI:60377
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB00095

metaR 5ADTSTSTERONEtr
fast: false
is: SBO:0000185
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
kinetic law: MODEL1310110024#
type: Reaction
is described by: ECO:0000000
name: 5 alpha dihydrotesterone intracellular transport
reactant: MODEL1310110024#
reversible: true

metaR SGALSIDEtl
is: SBO:0000185
reversible: true
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
name: sgalside hs intracellular transport
product: MODEL1310110024#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
fast: false

metaM ca2 e
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
name: calcium(2+)
constant: false
is: CHEBI:29108
is: HMDB00464
type: Species
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076

metaR r1381
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
kinetic law: MODEL1310110024#
fast: false
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5
reactant: MODEL1310110024#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
product: MODEL1310110024#
reversible: true

metaR PA HSter
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
name: phosphatidate scramblase
type: Reaction
reactant: MODEL1310110024#
fast: false
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reversible: true
is: SBO:0000185

metaM pail5p hs n
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
boundary condition: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
initial concentration: 1.0
has only substance units: false
is: CHEBI:57795
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)

metaM prostgh2 e
is: HMDB01381
initial amount: NaN
type: Species
is: CHEBI:57405
constant: false
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
name: prostaglandin H2(1-)
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaR r0408
kinetic law: MODEL1310110024#
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
modifier: MODEL1310110024#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.5
reactant: MODEL1310110024#
reversible: true

metaM succ c
name: Succinate
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
type: Species
initial concentration: 1.0
is: C00042
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:30031
is: SBO:0000247
is: HMDB00254
initial amount: NaN

metaR ACACt2m
kinetic law: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
is: SBO:0000185
is described by: ECO:0000269
name: Acetoacetate mitochondrial transport via H+ symport
reactant: MODEL1310110024#
modifier: MODEL1310110024#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110024#_4598aa68_2756_4a08_b620_77838bd68c72
is: P05177
initial amount: NaN
is encoded by: hsa:1544
type: Species
constant: false
boundary condition: true
name: CYP1A2
has only substance units: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110024#_a04d9a91_0481_4c57_832c_97537a8d4c85
type: Species
is: SBO:0000252
has only substance units: false
name: ADCY2
initial amount: NaN
is encoded by: hsa:108
is: Q71UM8
constant: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110024#_5336fdb2_e474_4844_b95d_864529b1798e
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:4711
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is: O43674
name: NDUFB5

metaM n2m2nmn l
notes: FORMULA: C50H84N4O36 CHARGE: 0
name: reducing GlcNAc removed form of n2m2nmasn (w/o peptide)
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:17588
has only substance units: false
is: HMDB00742

http://identifiers.org/biomodels.db/MODEL1310110024#_ae7f9707_bc42_4677_9c99_cf1b37605266
name: MAN2A2
is: Q9P1E4
is encoded by: hsa:4122
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species

metaR r0553
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
reactant: MODEL1310110024#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
fast: false
kinetic law: MODEL1310110024#
reversible: true

metaR 4HOXPACDOX NADP
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110024#
fast: false
reactant: MODEL1310110024#
modifier: MODEL1310110024#
product: MODEL1310110024#
name: 4-Hydroxyphenylacetaldehyde:NADP+ oxidoreductase
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
is described by: ECO:0000304
reversible: true
type: Reaction
is: SBO:0000176

metaR LNELDCCPT1
reversible: false
name: carnitine O-palmitoyltransferase
type: Reaction
reactant: MODEL1310110024#
fast: false
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110024#
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110024#

metaM hs deg13 l
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C55H83N3O61S5 CHARGE: -6
is: CHEBI:17180
boundary condition: false
type: Species
name: heparan sulfate, degradation product 13
is: HMDB01352

metaR r0407
reversible: true
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
fast: false
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
product: MODEL1310110024#
modifier: MODEL1310110024#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.4.3.5

metaM thcholstoic x
initial amount: NaN
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
is: CHEBI:18402
has only substance units: false
is: HMDB03873
is: SBO:0000247
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722

metaR GGH 7DHFe
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.4.19.9
product: MODEL1310110024#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
type: Reaction
name: Gamma-glutamyl hydrolase (7DHF), extracellular
fast: false
modifier: MODEL1310110024#

metaR ILETAm
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.42
fast: false
product: MODEL1310110024#
name: isoleucine transaminase, mitochondrial
reactant: MODEL1310110024#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
reversible: true

metaR G14T4g
fast: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
product: MODEL1310110024#
kinetic law: MODEL1310110024#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000000
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
modifier: MODEL1310110024#

metaR SBTR
is version of: http://identifiers.org/ec-code/1.1.1.21
fast: false
reversible: false
type: Reaction
product: MODEL1310110024#
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.1.1.2
is described by: ECO:0000269
name: D-sorbitol reductase
notes: GENE_ASSOCIATION: (8574.1) or (10327.1) or (231.1) or (10327.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:
modifier: MODEL1310110024#
is: SBO:0000176
reactant: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_47f902b0_7d3e_4cf8_a967_204c53da21bc
constant: false
initial amount: NaN
is: E9KL48
is encoded by: hsa:2746
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
name: GLUD1

metaR r2338
type: Reaction
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
fast: false
product: MODEL1310110024#
reactant: MODEL1310110024#
is: SBO:0000185
kinetic law: MODEL1310110024#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:

metaM pe hs e
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
name: phosphatidylethanolamine
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:16038

metaM cmp g
is: CHEBI:60377
name: CMP(2-)
constant: false
is: SBO:0000247
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB00095
initial concentration: 1.0

metaR r0552
kinetic law: MODEL1310110024#
fast: false
type: Reaction
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
is version of: http://identifiers.org/ec-code/1.3.5.1
product: MODEL1310110024#
reversible: true
reactant: MODEL1310110024#
modifier: MODEL1310110024#

metaM dhor S c
constant: false
initial concentration: 1.0
is: CHEBI:30864
boundary condition: false
type: Species
notes: FORMULA: C5H5N2O4 CHARGE: -1 INCHI: InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00285
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: (S)-dihydroorotate
is: HMDB03349

metaR TTDCRNt
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
kinetic law: MODEL1310110024#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110024#
type: Reaction
name: transport into the mitochondria (carnitine)
is: SBO:0000185
product: MODEL1310110024#
reactant: MODEL1310110024#

metaM ksii core2 pre4 g
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C53H86N4O38X CHARGE: -1
has only substance units: false
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 4
is: HMDB00175
type: Species
is: CHEBI:58053
boundary condition: false
constant: false
is: C00130

http://identifiers.org/biomodels.db/MODEL1310110024#_b2ae8a20_4fb9_4aaf_9499_70ec5b80090d
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:3712
type: Species
name: IVD
boundary condition: true
constant: false
is: B3KVI7

http://identifiers.org/biomodels.db/MODEL1310110024#_3d36a6ab_9564_4bf1_ad76_4be05cce4d7b
constant: false
is: SBO:0000252
is: Q9UHI7
name: SLC23A1
is encoded by: hsa:9963
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN

metaR r2358
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
kinetic law: MODEL1310110024#
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
is: SBO:0000185
reversible: true
product: MODEL1310110024#
reactant: MODEL1310110024#

metaR RTOTAL2t
reversible: true
type: Reaction
name: RTOTAL2 transport
kinetic law: MODEL1310110024#
fast: false
product: MODEL1310110024#
reactant: MODEL1310110024#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_4815453a_6088_4909_b7c0_e0f7ae0c93be
is encoded by: hsa:4713
has only substance units: false
type: Species
name: NDUFB7
is: P17568
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaM ksi pre4 g
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 4
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C101H165N7O72X CHARGE: -1
has only substance units: false
is: CHEBI:58053
is: HMDB00175
is: C00130
type: Species
boundary condition: false

metaR PSP L
kinetic law: MODEL1310110024#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8781.1) or (5723.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 3.1.3.3 Confidence Level: 4 AUTHORS: PMID:9188776,PMID:9573387 NOTES:
fast: false
is: SBO:0000176
name: phosphoserine phosphatase (L-serine)
modifier: MODEL1310110024#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.3
reversible: false
reactant: MODEL1310110024#
product: MODEL1310110024#

metaM ksi deg40 l
initial amount: NaN
is: CHEBI:12936
constant: false
notes: FORMULA: C40H68N2O31 CHARGE: 0
name: keratan sulfate I, degradation product 40
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB00143

metaM l2fn2m2masn g
type: Species
is: SBO:0000247
initial concentration: 1.0
name: {[galactosyl-(1,4)-N-Acetyl-glucosaminyl-(1,2)-mannosyl-(1,3)-],[N-acetyl-glucosaminyl-(1,2)-mannosyl-(1,6)-]mannosyl-(1,4)-N-acetyl-glucosaminyl-(1,4)-[fucosyl-(1,6)]-N-acetyl-glucosaminyl}asparagine
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:28067
has only substance units: false
notes: FORMULA: C68H113N4O49X CHARGE: 0

metaR r2359
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110024#
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110024#
is described by: ECO:0000000
type: Reaction

metaR 3SALATAim
kinetic law: MODEL1310110024#
product: MODEL1310110024#
is described by: ECO:0000304
name: 3-sulfino-alanine transaminase (irreversible), mitochondrial
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM. activity measured in rat, 3-sulfinoalanine is substrate found in human brain
modifier: MODEL1310110024#
is: SBO:0000176
reactant: MODEL1310110024#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_7e444df2_b835_455e_a717_1488a031e551
initial concentration: NaN
is: SBO:0000252
is: O95167
boundary condition: true
constant: false
name: NDUFA3
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:4696

http://identifiers.org/biomodels.db/MODEL1310110024#_8ae45d02_7069_41c3_aed9_2d918877a1c4
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q9BY07
name: SLC4A5
has only substance units: false
is encoded by: hsa:57835
type: Species

metaM arachcrn c
is: HMDB06460
has only substance units: false
constant: false
name: arachidyl carnitine
initial amount: NaN
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species

metaR r2200
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110024#
product: MODEL1310110024#

metaR q10h2tc
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110024#
is described by: ECO:0000134
fast: false
type: Reaction
product: MODEL1310110024#
reactant: MODEL1310110024#
name: transport of ubiquinol into cytosol

http://identifiers.org/biomodels.db/MODEL1310110024#_633c2c41_96e0_4cc6_a9d8_3949f5dcb171
type: Species
has only substance units: false
is encoded by: hsa:6818
is: Q1ET61
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
name: SULT1A3

metaM dlnlcgcoa r
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
is: CHEBI:27979
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
is: C03595
name: dihomo-gamma-linolenyl coenzyme A
initial amount: NaN

metaR NDPK10
reversible: true
name: nucleoside-diphosphate kinase (ATP:dIDP)
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110024#
fast: false
product: MODEL1310110024#
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
type: Reaction
is: SBO:0000176
reactant: MODEL1310110024#

metaM succoa m
is: SBO:0000247
initial concentration: 1.0
is: HMDB01022
type: Species
initial amount: NaN
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
is: CHEBI:57292
name: Succinyl-CoA
has only substance units: false
boundary condition: false
constant: false

metaR MTHFCm
product: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false
modifier: MODEL1310110024#
type: Reaction
name: methenyltetrahydrifikate cyclohydrolase, mitochondrial
is version of: http://identifiers.org/ec-code/3.5.4.9
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.3.4.3
reactant: MODEL1310110024#
is: SBO:0000176

metaM CE2418 m
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
is: HMDB11123
constant: false
type: Species
boundary condition: false
is: CHEBI:28387
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110024#_2316ea65_9356_4abe_a13a_ff46a37d3ce0
name: BCAT2
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
is: O15382
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:587

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

metaM mma c
notes: FORMULA: C1H6N CHARGE: 1 INCHI: InChI=1S/CH5N/c1-2/h2H2,1H3/p+1 EHMN_ABBREVIATION: C00218
name: methylammonium
constant: false
boundary condition: false
has only substance units: false
is: HMDB00164
is: CHEBI:59338
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247

metaM hx2coa m
is: SBO:0000247
initial amount: NaN
name: trans-Hex-2-enoyl-CoA
is: HMDB13037
constant: false
boundary condition: false
has only substance units: false
is: C00888
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_6bcc7304_f87f_44f8_9a10_8032317d0420
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:160851
has only substance units: false
initial concentration: NaN
name: DGKH
type: Species
is: A8K0I1

http://identifiers.org/biomodels.db/MODEL1310110024#_57aee6ec_d5ff_425c_8923_996d0565fd68
boundary condition: true
name: PIGX:PIGM
has part: Q8TBF5
is encoded by: hsa:93183
is: SBO:0000297
type: Species
is encoded by: hsa:54965
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
has part: Q9H3S5

http://identifiers.org/biomodels.db/MODEL1310110024#_5a81f9e1_3253_407f_81a5_5912bf3e09b7
has only substance units: false
is encoded by: hsa:6576
boundary condition: true
type: Species
is: D9HTE9
initial concentration: NaN
constant: false
is: SBO:0000252
name: SLC25A1
initial amount: NaN

metaR EX glyleu LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Glycylleucine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_6ccf7249_041f_45c8_8f45_379370a9b176
is: Q99944
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: EGFL8
is encoded by: hsa:80864
type: Species
constant: false

metaM ksii core4 pre8 g
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB00175
is: C00130
notes: FORMULA: C83H134N7O61SX CHARGE: -2
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 8
boundary condition: false
constant: false
is: CHEBI:58053

metaR r2201
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110024#
reactant: MODEL1310110024#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5

metaR SIAT4Bg
name: Beta-galactoside alpha-2,3-sialyltransferase, Golgi apparatus
modifier: MODEL1310110024#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.4.99.4
reactant: MODEL1310110024#
is described by: ECO:0000269
kinetic law: MODEL1310110024#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
product: MODEL1310110024#

metaR EX eicostet LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: eicosatetranoic acid exchange
type: Reaction

metaR r2356
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
type: Reaction
fast: false
name: Organic anion transporter 5 Utilized transport
reversible: true
product: MODEL1310110024#
is described by: ECO:0000000
is: SBO:0000185

metaM fol e
initial amount: NaN
name: Folate
type: Species
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C19H18N7O6 CHARGE: -1
is: HMDB00121

metaR DM anth
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

metaM 3octdectecoa m
boundary condition: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/5280355
type: Species
has only substance units: false
initial concentration: 1.0
name: 3,6,9,12-octadecatetraenoylcoa
initial amount: NaN
constant: false
is: SBO:0000247

metaM nadp x
is: SBO:0000247
is: C00006
type: Species
constant: false
has only substance units: false
is: CHEBI:58349
boundary condition: false
name: Nicotinamide adenine dinucleotide phosphate
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: HMDB00217

metaR r2202
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
kinetic law: MODEL1310110024#
is: SBO:0000185
type: Reaction
fast: false
modifier: MODEL1310110024#
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM m6masnB2 g
boundary condition: false
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: HMDB06529
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C58H97N2O45X CHARGE: 0
is: CHEBI:50570
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)

metaM stcrn c
initial amount: NaN
constant: false
name: stearoylcarnitine
is: SBO:0000247
boundary condition: false
is: HMDB00848
type: Species
notes: FORMULA: C25H49NO4 CHARGE: 0 INCHI: InChI=1/C25H49NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h23H,5-22H2,1-4H3
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_6f39abb4_0c7f_4fa4_ba1c_cc556c91a217
name: _R39999_1_c
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:R39999

http://identifiers.org/biomodels.db/MODEL1310110024#_188bdc72_7e12_42b9_b426_2335cd61cf0e
type: Species
is: A4D1M2
is: SBO:0000252
name: CPA5
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:93979

metaM damp c
is: HMDB00905
name: dAMP(2-)
initial concentration: 1.0
is: CHEBI:58245
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
constant: false

metaR r2357
fast: false
reversible: true
kinetic law: MODEL1310110024#
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
is: SBO:0000185
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000000

metaR CRVNCtr
product: MODEL1310110024#
is described by: ECO:0000000
kinetic law: MODEL1310110024#
type: Reaction
reversible: true
name: fatty acid transport via diffusion
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
is: SBO:0000185

metaR C6COAt
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: esterification of of hexanoylcoa for transport into cytosol
type: Reaction

metaR SERGLNNaEx
reversible: false
reactant: MODEL1310110024#
is: SBO:0000185
is described by: ECO:0000269
name: L-serine/L-glutamine Na-dependent exchange (Ser-L in)
type: Reaction
modifier: MODEL1310110024#
fast: false
kinetic law: MODEL1310110024#
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

http://identifiers.org/biomodels.db/MODEL1310110024#_dd5ddd19_f982_43c0_be7c_45966af3a2ee
name: CA13
type: Species
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
is: Q8N1Q1
is encoded by: hsa:377677
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_a88a36fd_f963_4412_926b_57569517af90
initial amount: NaN
has only substance units: false
is: E5KNH5
name: NDUFV1
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4723
constant: false

metaR HPDCACRNCPT1
is: SBO:0000176
reactant: MODEL1310110024#
is described by: ECO:0000000
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine fatty-acyl transferase
reversible: false
notes: GENE_ASSOCIATION: (1375.2) or (1375.3) or (1374.1) or (126129.1) or (1375.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:NJ
product: MODEL1310110024#
fast: false
type: Reaction
kinetic law: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_3a1a2cdb_5b62_4f11_bf61_8f946419f544
is encoded by: hsa:3036
is: SBO:0000252
boundary condition: true
is: Q8IYH3
name: HAS1
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
constant: false

metaM idp n
is: HMDB03335
is: CHEBI:58280
name: IDP(3-)
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104

metaM asp L m
name: L-aspartate(1-)
is: CHEBI:29991
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
type: Species
boundary condition: false
is: HMDB00191
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_450049d2_ea4c_4ada_b86b_0bf6ba8a5087
type: Species
name: UEVLD
initial amount: NaN
is encoded by: hsa:55293
constant: false
boundary condition: true
initial concentration: NaN
is: Q8IX04
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110024#_0ff1708c_d38e_471e_b778_f0fac42028be
is: SBO:0000252
constant: false
has only substance units: false
is: P30048
boundary condition: true
initial amount: NaN
type: Species
name: PRDX3
is encoded by: hsa:10935
initial concentration: NaN

metaM 3hexdtricoa x
initial concentration: 1.0
type: Species
is: HMDB02288
boundary condition: false
name: 3,7,10-hexadecatrienoylcoa
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN

metaR RE1530C
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
name: RE1530
reactant: MODEL1310110024#
product: MODEL1310110024#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
kinetic law: MODEL1310110024#

metaR S6TASE3ly
product: MODEL1310110024#
kinetic law: MODEL1310110024#
reversible: true
name: N-acetylglucosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.14
reactant: MODEL1310110024#
modifier: MODEL1310110024#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
type: Reaction
fast: false

metaM trp L c
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB00929
type: Species
constant: false
has only substance units: false
name: L-tryptophan
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
is: CHEBI:16828
initial concentration: 1.0

metaM ile L e
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
name: L-isoleucine
type: Species
is: CHEBI:17191
initial concentration: 1.0
is: HMDB00172
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_8a7b1896_504b_45b2_a966_bf9e16bb1e90
is encoded by: hsa:2348
type: Species
initial amount: NaN
name: FOLR1
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false

metaM fol c
has only substance units: false
type: Species
name: Folate
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C19H18N7O6 CHARGE: -1
is: HMDB00121

http://identifiers.org/biomodels.db/MODEL1310110024#_13b6789b_3e9a_4d23_b6b0_3355bd55b422
initial concentration: NaN
is encoded by: hsa:9435
constant: false
is: Q9Y4C5
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
name: CHST2

metaM fadh2 m
is: HMDB01197
has only substance units: false
is: CHEBI:58307
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
name: Flavin adenine dinucleotide reduced
is: SBO:0000247
constant: false
initial concentration: 1.0
is: C01352

http://identifiers.org/biomodels.db/MODEL1310110024#_b0d69e6f_c2a9_45bd_9557_a48b808b565d
has only substance units: false
initial amount: NaN
is encoded by: hsa:BG035985
name: _BG035985_1_c
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
type: Species

metaM nadh c
constant: false
initial amount: NaN
is: HMDB01487
boundary condition: false
is: C00004
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3306
is: CHEBI:57945
name: Nicotinamide adenine dinucleotide - reduced
type: Species

metaR FAOXTC101TC102m
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C10:1-->C10:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_bc169617_1080_4585_a762_d58dd5cfc3f0
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:8050
is: O00330
is: SBO:0000252
name: PDHX
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_36f7e0e2_771c_4e4a_ace9_888530431e33
initial amount: NaN
initial concentration: NaN
constant: false
name: SLC25A14
boundary condition: true
is encoded by: hsa:9016
type: Species
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_9eed4a62_7332_42a4_901a_5f344e3f6803
is: B4E1R2
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1491
type: Species
is: SBO:0000252
boundary condition: true
name: CTH
constant: false
has only substance units: false

metaR HPDCACRNCPT2
fast: false
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
type: Reaction
name: heptadecanoate transport into the mitochondria
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110024#
product: MODEL1310110024#

metaR CYSSERNaEx
name: L-serine/L-cysteine Na-dependent exchange (Cys-L in)
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
kinetic law: MODEL1310110024#
fast: false
modifier: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
reversible: false
reactant: MODEL1310110024#
is: SBO:0000185

metaR DGCHOLte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is: SBO:0000185
kinetic law: MODEL1310110024#
fast: false
name: bile acid intracellular transport
product: MODEL1310110024#
reactant: MODEL1310110024#
type: Reaction
reversible: true
is described by: ECO:0000000

metaR TXA2te
product: MODEL1310110024#
name: thromboxane A2 transport
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism for transport - known to be secreted from cells - unknown mechanism or pathway, TXA2tc -> TXA2te to get to EC space NJ
is: SBO:0000185
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000000

metaM s2l2n2m2mn l
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB06529
name: de-Fuc, reducing GlcNAc removed form of PA6 (w/o peptide linkage)
is: CHEBI:50570
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C76H123N5O57 CHARGE: -2
constant: false

metaM o2s m
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:18421
is: C00704
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
initial concentration: 1.0
name: Superoxide anion
constant: false
boundary condition: false
type: Species
is: HMDB02168

metaR PTE3x
is: SBO:0000176
reversible: false
name: peroxisomal acyl-CoA thioesterase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10965.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10944470 NOTES:NJ
product: MODEL1310110024#
modifier: MODEL1310110024#
type: Reaction
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.1.2.2
reactant: MODEL1310110024#
fast: false

metaR PTDCACRNCPT1
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110024#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
notes: GENE_ASSOCIATION: (1375.1) or (1375.4) or (1375.3) or (1374.1) or (126129.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:NJ
name: carnitine fatty-acyl transferase
is: SBO:0000176
reactant: MODEL1310110024#
product: MODEL1310110024#
modifier: MODEL1310110024#

metaR NRVNCt
is: SBO:0000185
reactant: MODEL1310110024#
fast: false
name: fatty acid transport via diffusion
type: Reaction
product: MODEL1310110024#
kinetic law: MODEL1310110024#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

metaR BTNt4i
name: Biotin uptake (antiport)
is: SBO:0000185
modifier: MODEL1310110024#
reversible: false
kinetic law: MODEL1310110024#
is described by: ECO:0000269
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
fast: false
type: Reaction
reactant: MODEL1310110024#

metaR PTPATe
reversible: true
is described by: ECO:0000134
kinetic law: MODEL1310110024#
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110024#
name: PTPATe
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR TYRt
fast: false
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
type: Reaction
reversible: true
name: L-tyrosine transport
kinetic law: MODEL1310110024#
product: MODEL1310110024#
is: SBO:0000185
modifier: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000269

metaR r0441
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.40
kinetic law: MODEL1310110024#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
is: SBO:0000176
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
product: MODEL1310110024#
modifier: MODEL1310110024#
reversible: true
reactant: MODEL1310110024#
type: Reaction

metaR CYTK13n
kinetic law: MODEL1310110024#
fast: false
reactant: MODEL1310110024#
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110024#
name: cytidylate kinase (dCMP,dATP),nuclear
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_0c9c6afb_0b9b_401c_b0e6_93df98bf8f17
boundary condition: true
initial amount: NaN
is encoded by: hsa:11001
initial concentration: NaN
constant: false
name: SLC27A2
has only substance units: false
is: SBO:0000252
type: Species
is: O14975

http://identifiers.org/biomodels.db/MODEL1310110024#_7c7aa99c_37ff_4024_a81a_95b860011138
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
name: SOD2
is: P04179
constant: false
is encoded by: hsa:6648
initial concentration: NaN
is: SBO:0000252

metaM ksi deg17 l
type: Species
is: CHEBI:12936
initial concentration: 1.0
notes: FORMULA: C152H245N10O132S7 CHARGE: -7
constant: false
name: keratan sulfate I, degradation product 17
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB00143
is: SBO:0000247

metaR r1678
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110024#
reversible: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
modifier: MODEL1310110024#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110024#
fast: false
product: MODEL1310110024#

metaR B3GALT3g
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000269
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (8706.4) or (8706.1) or (8706.3) or (8706.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.79 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.4.1.79
name: Beta-1,3-galactosyltransferase 3
kinetic law: MODEL1310110024#
reversible: false
is: SBO:0000176
type: Reaction
fast: false

metaM hs deg9 l
notes: FORMULA: C61H87N3O76S8 CHARGE: -10
type: Species
name: heparan sulfate, degradation product 9
is: CHEBI:17115
initial amount: NaN
is: HMDB00187
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

W3 CDTF: Thu Aug 30 19:37:47 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110024#_a15b9aa3_d35f_49c1_ad6b_e910d455ff54
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaM hs deg22 l
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB02704
name: IdoA-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
is: CHEBI:21338
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C37H56NO35S CHARGE: -3
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_a504199c_0ab4_4f45_bf78_94315fcd7e54
is: SBO:0000252
constant: false
type: Species
has only substance units: false
name: _D29675_1_c
initial concentration: NaN
is encoded by: hsa:D29675
initial amount: NaN
boundary condition: true

metaR IZPN
is: SBO:0000176
name: Imidazolonepropionase
is described by: ECO:0000000
product: MODEL1310110024#
reactant: MODEL1310110024#
type: Reaction
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110024#

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

metaR PTDCACRNCPT2
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ
reactant: MODEL1310110024#
product: MODEL1310110024#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110024#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110024#
reversible: false
type: Reaction
name: pentadecanoate transport into the mitochondria

metaR SRTNtu
fast: false
product: MODEL1310110024#
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110024#
is described by: ECO:0000269
kinetic law: MODEL1310110024#
name: Serotonin uniport
notes: GENE_ASSOCIATION: (6580.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
modifier: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_3af28d38_e3c3_4ed4_9aaa_12de87e00b8d
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: E7EUT4
name: GAPDH
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:2597

metaR CERT1gt
is: SBO:0000185
reactant: MODEL1310110024#
product: MODEL1310110024#
reversible: true
modifier: MODEL1310110024#
is described by: ECO:0000304
type: Reaction
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
kinetic law: MODEL1310110024#
fast: false
name: ceramide transport protein
is version of: http://identifiers.org/ec-code/2.7.11.1

W3 CDTF: Thu Aug 30 19:37:47 BST 2012

metaR r2079
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110024#
is described by: ECO:0000000
is: SBO:0000185
fast: false
modifier: MODEL1310110024#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110024#
type: Reaction
reactant: MODEL1310110024#

metaR NACHEXA21ly
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
reactant: MODEL1310110024#
modifier: MODEL1310110024#
name: beta-N-acetylhexosaminidase A, lysosomal
kinetic law: MODEL1310110024#
type: Reaction
is described by: ECO:0000000
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
product: MODEL1310110024#

metaR CYSGLUexR
is: SBO:0000185
name: L-cysteine/L-glutamine reversible exchanger
reactant: MODEL1310110024#
modifier: MODEL1310110024#
reversible: true
product: MODEL1310110024#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
fast: false
kinetic law: MODEL1310110024#

metaR C4DCCACT
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinyl carnitine into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_72311861_3750_402b_8156_1492e73fd881
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

metaR r1567
type: Reaction
reactant: MODEL1310110024#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110024#
fast: false
reversible: true
product: MODEL1310110024#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR FAOXC141C121x
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C14:1-->C12:1)x
type: Reaction

metaR 3HLYTCL
is: SBO:0000176
reversible: false
fast: false
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: NOTES:SAB
is described by: ECO:0000269
name: 3-Hydroxy-L-tyrosine carboxy-lyase
type: Reaction
modifier: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/4.1.1.28
kinetic law: MODEL1310110024#

metaR BHBt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
is: SBO:0000185
product: MODEL1310110024#
reversible: true
type: Reaction
reactant: MODEL1310110024#
fast: false
kinetic law: MODEL1310110024#
is described by: ECO:0000000
name: (R)-3-Hydroxybutanoate transport via H+ symport

metaR TXA2tr
reversible: true
name: thromboxane A2 intracellular transport
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism for transport - known to be secreted from cells - unknown mechanism or pathway, TXA2tr -> TXA2te to get to EC space NJ
is: SBO:0000185
reactant: MODEL1310110024#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110024#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_5349f01f_44a9_4fd2_9634_e0e39f24c755
type: Species
constant: false
initial amount: NaN
name: PPCDC
has only substance units: false
initial concentration: NaN
is: Q96CD2
is encoded by: hsa:60490
boundary condition: true
is: SBO:0000252

metaR UAG4E
is version of: http://identifiers.org/ec-code/5.1.3.2
modifier: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000176
is described by: ECO:0000304
name: UDP-N-acetylglucosamine 4-epimerase
reversible: true
reactant: MODEL1310110024#
product: MODEL1310110024#
fast: false
kinetic law: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_a476a794_d750_4500_850b_5c21aba0e35f
has only substance units: false
initial concentration: NaN
is: Q13454
is encoded by: hsa:7991
name: TUSC3
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
constant: false

metaR MM6B2g
product: MODEL1310110024#
fast: false
type: Reaction
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
modifier: MODEL1310110024#
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.2.1.113
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110024#
reversible: false
is: SBO:0000176

metaM r1p c
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442
is: C00442
is: HMDB01489
constant: false
is: CHEBI:57720
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: alpha-D-Ribose 1-phosphate
boundary condition: false
type: Species
initial amount: NaN

metaM T4hcinnm m
is: SBO:0000247
boundary condition: false
notes: FORMULA: C9H7O3 CHARGE: -1 INCHI: InChI=1S/C9H8O3/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6,10H,(H,11,12)/p-1/b6-3+ EHMN_ABBREVIATION: C00811
is: HMDB02035
type: Species
name: trans-4-coumarate
constant: false
initial amount: NaN
is: CHEBI:12876
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_87722a57_3327_4cd8_abf7_b772e20d6984
boundary condition: true
initial concentration: NaN
constant: false
is: O60312
name: ATP10A
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:57194
type: Species

metaR PEt
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:
reversible: true
kinetic law: MODEL1310110024#
product: MODEL1310110024#
name: phosphatidylethanolamine transport
is: SBO:0000185

metaR S6TASE9ly
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110024#
name: N-acetylgalactosamine-6-sulfatase, lysosomal
reversible: true
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110024#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110024#_fcf53807_7b8d_44c7_8445_151e0ccb7973
type: Species
initial concentration: NaN
is: Q5T4W8
constant: false
initial amount: NaN
name: ST3GAL3
is: SBO:0000252
is encoded by: hsa:6487
boundary condition: true
has only substance units: false

metaM HC01162 c
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58376
has only substance units: false
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
type: Species
constant: false
is: SBO:0000247

metaR S6TASE18ly
modifier: MODEL1310110024#
fast: false
type: Reaction
reversible: true
product: MODEL1310110024#
is: SBO:0000176
kinetic law: MODEL1310110024#
name: N-acetylglucosamine-6-sulfatase, lysosomal
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.14

metaR r1566
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110024#
reversible: true
kinetic law: MODEL1310110024#
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110024#

metaR AICART
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110024#
fast: false
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
product: MODEL1310110024#
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.2.3
kinetic law: MODEL1310110024#
is: SBO:0000176
name: phosphoribosylaminoimidazolecarboxamide formyltransferase

metaM 5aizc c
constant: false
is: C04751
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
initial concentration: 1.0
notes: FORMULA: C9H11N3O9P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01347 EHMN_ABBREVIATION: C04751
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:58564
is: HMDB06273
initial amount: NaN

metaR r1569
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110024#
is: SBO:0000185
reversible: true
product: MODEL1310110024#
type: Reaction
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR NADPHtxu
reversible: false
fast: false
type: Reaction
name: NADPH transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES:diffusion - unidirectional to avoid NADP/NAD loops w/ free hydrogens NJ
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is: SBO:0000185
is described by: ECO:0000000

metaR RAI1
reversible: true
kinetic law: MODEL1310110024#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
product: MODEL1310110024#
name: retinal isomerase (11-cis)
fast: false

metaR NP1
modifier: MODEL1310110024#
fast: false
product: MODEL1310110024#
kinetic law: MODEL1310110024#
is described by: ECO:0000304
reactant: MODEL1310110024#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.1
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: NAD metabolism EC Number: 3.4.2.1 Confidence Level: 2 AUTHORS: NOTES:NCD
name: nucleotide phosphatase
is: SBO:0000176

metaR S6TASE15ly
fast: false
reversible: true
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.1.6.14
is described by: ECO:0000000
modifier: MODEL1310110024#
is: SBO:0000176
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reactant: MODEL1310110024#
name: N-acetylglucosamine-6-sulfatase, lysosomal
type: Reaction

metaR SUCRe
type: Reaction
reversible: false
name: sucrose hydrolyzing enxyme, extracellular
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.10
notes: GENE_ASSOCIATION: (6476.1) or (8972.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.26 Confidence Level: 4 AUTHORS: PMID:1560017,PMID:3143729 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.20
is described by: ECO:0000269
reactant: MODEL1310110024#
product: MODEL1310110024#
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false

metaR RE1521M
product: MODEL1310110024#
reactant: MODEL1310110024#
modifier: MODEL1310110024#
is: SBO:0000176
kinetic law: MODEL1310110024#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
name: RE1521
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false

metaR BDMT L
product: MODEL1310110024#
reversible: false
kinetic law: MODEL1310110024#
name: GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (liver)
is version of: http://identifiers.org/ec-code/2.4.1.142
notes: GENE_ASSOCIATION: (56052.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
fast: false
is described by: ECO:0000000
modifier: MODEL1310110024#
type: Reaction
reactant: MODEL1310110024#

metaR r1568
is: SBO:0000185
reactant: MODEL1310110024#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110024#
fast: false
product: MODEL1310110024#

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

metaR RAI2
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
kinetic law: MODEL1310110024#
name: retinal isomerase (9-cis)
reactant: MODEL1310110024#
reversible: true
is: SBO:0000176
product: MODEL1310110024#

metaM docosahexcoa m
initial amount: NaN
name: 3,7,10,13,16,19-docosahexenoylcoa
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
constant: false
is: http://identifiers.org/pubchem.compound/24892790
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110024#_5ea5cc06_e52d_48c6_af6f_7a7efd9b426b
name: ADSL
is encoded by: hsa:158
has only substance units: false
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaM dcsptn1crn c
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
is: HMDB06321
name: docosa-4,7,10,13,16-pentaenoyl carnitine
has only substance units: false
type: Species

metaM andrstandn r
is: SBO:0000247
boundary condition: false
is: HMDB00899
name: 5alpha-androstane-3,17-dione
has only substance units: false
is: CHEBI:15994
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
constant: false
type: Species

metaM trp L e
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: L-tryptophan
constant: false
initial amount: NaN
is: CHEBI:16828
boundary condition: false
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
is: HMDB00929

http://identifiers.org/biomodels.db/MODEL1310110024#_eb885ebb_c613_40a3_8370_6f85accc8829
is: Q6IBB5
type: Species
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:4694
boundary condition: true
name: NDUFA1
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_c85cd943_c16e_406e_9e06_a261ee4cd97a
name: UCP3
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:7352
boundary condition: true
is: P55916
has only substance units: false
initial amount: NaN

metaM ile L c
type: Species
constant: false
name: L-isoleucine
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: SBO:0000247
is: HMDB00172
initial concentration: 1.0
is: CHEBI:17191
initial amount: NaN
boundary condition: false
has only substance units: false

metaR r0002
is: SBO:0000185
fast: false
kinetic law: MODEL1310110024#
reversible: true
reactant: MODEL1310110024#
name: Active transport
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
is described by: ECO:0000000
type: Reaction

metaR FAOXC205C184x
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:5-->C18:4)x
type: Reaction

metaR H3ETer
reactant: MODEL1310110024#
is described by: ECO:0000304
product: MODEL1310110024#
kinetic law: MODEL1310110024#
type: Reaction
fast: false
is: SBO:0000176
name: H3 phosphoethanolaminyl transferase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (23556.1) or (23556.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10574991 NOTES:NCD
reversible: false
modifier: MODEL1310110024#

metaR GLCAASE1ly
is: SBO:0000176
name: beta-glucuronidase, lysosomal
modifier: MODEL1310110024#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.31
fast: false
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
reversible: false
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110024#

metaR r2354
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110024#
reversible: true
type: Reaction
product: MODEL1310110024#
is: SBO:0000185
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
fast: false

metaR FAOXC226m
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:6)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_a66a19e8_26e1_4068_97d6_40b850cd2110
is: SBO:0000252
is: B7Z2M9
has only substance units: false
name: DGKZ
initial concentration: NaN
is encoded by: hsa:8525
initial amount: NaN
constant: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_90be9cbe_9c16_42ee_9b9e_4ed34fc25d98
name: ACP6
initial amount: NaN
is: Q9NPH0
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:51205
type: Species
initial concentration: NaN

metaM estradiol r
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
is: SBO:0000247
is: HMDB00151
constant: false
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:16469
has only substance units: false
name: estradiol
initial concentration: 1.0

metaM 3mop c
is: SBO:0000247
boundary condition: false
name: 3-methyl-2-oxopentanoate
is: HMDB00491
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
is: CHEBI:28654
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671

metaR EX thymd LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymidine exchange
type: Reaction

metaM strdnccoa x
is: C16163
is: http://identifiers.org/pubchem.compound/47205473
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
name: stearidonyl coenzyme A
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: HMDB06519
is: SBO:0000247
boundary condition: false

metaR DPPS
fast: false
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110024#
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: Confidence Level: 2 AUTHORS: PMID:16262699 NOTES:by analogy to other dimethyl transferase rxns. See PMID: 10586494, human interemidate (from C15 ->C50) not explicitly determined yet, however it is known to occur since this pathway is essential in Q10 synthesis. For human metabolism: may be associated w/ GeneID: 23590 TPRT - recheck lit in future IT and NJ
is described by: ECO:0000134
reactant: MODEL1310110024#
name: decaprenyl synthase
type: Reaction

metaR r0339
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.2.22
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.65
modifier: MODEL1310110024#
reversible: false
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.1.2.2
fast: false
is described by: ECO:0000000
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31

metaM m7mpdol U r
has only substance units: false
notes: FORMULA: C1665H2740N20O570P20 CHARGE: -20
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: (alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
type: Species
is: CHEBI:37636

metaR r2355
fast: false
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is: SBO:0000185
type: Reaction
product: MODEL1310110024#
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
reversible: true

metaR FAOXC163GC142m
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)gm
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_9aa22ffa_2b32_4e02_ac95_030c32f93faa
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:1545
boundary condition: true
is: Q16678
is: SBO:0000252
name: CYP1B1
has only substance units: false

metaR EX gum LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange reaction for guar gums
type: Reaction

metaR r1831
fast: false
product: MODEL1310110024#
reversible: false
reactant: MODEL1310110024#
is: SBO:0000185
modifier: MODEL1310110024#
name: Y+LAT2 Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_191dbe62_d164_4577_b223_8d8c2238935b
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
type: Species
name: NDUFB7
is: P17568
is encoded by: hsa:4713

http://identifiers.org/biomodels.db/MODEL1310110024#_5f795726_3570_4194_b4b9_c003949b7780
initial amount: NaN
constant: false
is: Q9H2F3
is encoded by: hsa:80270
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
name: HSD3B7
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_da403082_399c_4944_a40d_ae51f2c10b55
is: SBO:0000252
constant: false
type: Species
boundary condition: true
is: Q7GXZ4
initial amount: NaN
has only substance units: false
name: ND4L
initial concentration: NaN
is encoded by: hsa:4539

http://identifiers.org/biomodels.db/MODEL1310110024#_354a80a9_7a7e_450d_a1f5_c931e714cdce
name: ARSB
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:411
is: P15848
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_d41c4bf6_c336_4a06_b145_8e9aeadac4ab
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
constant: false
name: _AI091231_1_c
is encoded by: hsa:AI091231
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_cd569a7c_65dc_42f1_964a_92e74aed1992
is: P47895
is: SBO:0000252
boundary condition: true
name: ALDH1A3
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:220

metaR DOLMANP Uter
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
is: SBO:0000185
fast: false
reactant: MODEL1310110024#
type: Reaction
reversible: false
name: dolichol-phosphate mannose flippase (uterus)
is described by: ECO:0000000
kinetic law: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_e68596bf_ed6c_4dda_ad9d_137b41923177
type: Species
is: SBO:0000252
is: Q92536
initial amount: NaN
is encoded by: hsa:9057
name: SLC7A6
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false

metaR r0193
product: MODEL1310110024#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
fast: false
reactant: MODEL1310110024#
is described by: ECO:0000000
type: Reaction
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
kinetic law: MODEL1310110024#
reversible: true

metaR NADPtxu
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES:diffusion - unidirectional to avoid NADP/NAD loops w/ potential for free H NJ
reversible: false
product: MODEL1310110024#
fast: false
is: SBO:0000185
name: NADP transporter, peroxisome
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#

metaR FUMSO4tm
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is described by: ECO:0000269
product: MODEL1310110024#
name: Fumarate:sulfate antiport, mitochondrial
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110024#_52c13312_b66f_4611_aff2_cf805cc7caf9
is encoded by: hsa:65263
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: Q53H96
name: PYCRL
type: Species
boundary condition: true
constant: false
initial amount: NaN

metaM idp e
is: HMDB03335
is: CHEBI:58280
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
type: Species
initial amount: NaN
name: IDP(3-)
boundary condition: false
initial concentration: 1.0

metaR r2352
fast: false
reversible: true
reactant: MODEL1310110024#
type: Reaction
product: MODEL1310110024#
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000

metaR HISCAT1
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_78b1ca1c_90fb_4d1e_83ad_9ee13327edef
boundary condition: true
name: _AA664770_1_m
has only substance units: false
constant: false
is encoded by: hsa:AA664770
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_98b0b687_d963_4d06_bb70_ec5a61d55943
is encoded by: hsa:6526
initial concentration: NaN
has only substance units: false
name: SLC5A3
initial amount: NaN
is: P53794
is: SBO:0000252
constant: false
type: Species
boundary condition: true

metaR r0706
is described by: ECO:0000000
name: acyl-Coenzyme A dehydrogenase family, member 9 Bile acid biosynthesis EC:1.3.3.6
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.99.10
reversible: false
is: SBO:0000176
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (34.1) or (3712.1) or (R14373.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356170,PMID:8943006 NOTES:RE1814X
fast: false
type: Reaction
product: MODEL1310110024#
modifier: MODEL1310110024#

metaM 2mbcoa m
has only substance units: false
boundary condition: false
name: 2-methylbutanoyl-CoA(4-)
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB01041
is: CHEBI:57336
constant: false
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
initial concentration: 1.0

metaM m6mpdol U r
boundary condition: false
is: CHEBI:37635
type: Species
initial concentration: 1.0
notes: FORMULA: C1605H2640N20O520P20 CHARGE: -20
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
name: (alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog

metaM fadh2 r
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
has only substance units: false
initial amount: NaN
constant: false
is: HMDB01197
name: FADH2(2-)
is: CHEBI:58307
is: SBO:0000247

metaR RE1796R
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.1.1.145
name: RE1796
reversible: true
is: SBO:0000176
product: MODEL1310110024#
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110024#_61c1b657_d376_4478_a43f_e65311b63eda
has only substance units: false
is encoded by: hsa:26
boundary condition: true
initial amount: NaN
name: ABP1
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
is: P19801

metaR r2353
is described by: ECO:0000000
product: MODEL1310110024#
reversible: true
kinetic law: MODEL1310110024#
is: SBO:0000185
type: Reaction
fast: false
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110024#

metaR UAG2EMAi
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/5.1.3.14
name: UDP-N-acetyl-D-glucosamine 2-epimerase (Hydrolysis)
type: Reaction
reversible: false
reactant: MODEL1310110024#
is: SBO:0000176
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835 NOTES:
product: MODEL1310110024#

metaM xol7ah2al m
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
is: HMDB06894
is: CHEBI:27428
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_0c9381ad_53b5_45e9_be65_8d92be91991c
boundary condition: true
is: SBO:0000252
is: P07205
type: Species
initial amount: NaN
constant: false
name: PGK2
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5232

http://identifiers.org/biomodels.db/MODEL1310110024#_23095d73_75da_46c4_a227_3c2119e0e437
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:513
is: SBO:0000252
has only substance units: false
name: ATP5D

metaR r0707
is: SBO:0000176
product: MODEL1310110024#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.168
type: Reaction
name: 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate phosphohydrolase (alkaline optimum) Folate biosynthesis EC:3.1.3.1
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (1629.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777 NOTES:
reactant: MODEL1310110024#
is described by: ECO:0000000
kinetic law: MODEL1310110024#
fast: false

metaR C14STRr
is described by: ECO:0000134
fast: false
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.3.1.70
name: C-14 sterol reductase
reactant: MODEL1310110024#
type: Reaction
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
reversible: false
kinetic law: MODEL1310110024#
is: SBO:0000176

metaR EX CE5798 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: neuromedin N (1-4) exchange
type: Reaction

metaM idp c
is: HMDB03335
has only substance units: false
is: CHEBI:58280
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
constant: false
name: IDP(3-)
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110024#_eabeab43_25d4_4973_91b7_4e6c6e45b897
is encoded by: hsa:AA177072
is: SBO:0000252
initial concentration: NaN
name: _AA177072_1_c
constant: false
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true

metaM hyptaur c
has only substance units: false
name: Hypotaurine
type: Species
is: HMDB00965
is: CHEBI:16668
is: SBO:0000247
boundary condition: false
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
constant: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_2aad7bac_e5b0_4387_9fa7_2e00be5f3494
constant: false
boundary condition: true
type: Species
is: SBO:0000297
has only substance units: false
initial concentration: NaN
has part: Q9UHI5
is encoded by: hsa:23428
name: SLC7A8:SLC3A2
initial amount: NaN

metaR r0191
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (7915.1) or (9856.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275,PMID:4276999 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.24
is: SBO:0000176
name: UTP:D-fructose-6-phosphate 1-phosphotransferase EC:2.7.1.11
fast: false
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110024#
reversible: false

metaR NACHEX9ly
kinetic law: MODEL1310110024#
is described by: ECO:0000000
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110024#
type: Reaction
fast: false
modifier: MODEL1310110024#
reversible: false
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR LEUt5m
kinetic law: MODEL1310110024#
product: MODEL1310110024#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
name: leucine mitochondrial transport
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110024#

metaM phyt c
initial concentration: 1.0
name: phytanate
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
boundary condition: false
is: HMDB00801
is: CHEBI:37257

http://identifiers.org/biomodels.db/MODEL1310110024#_f52436f5_f750_4384_aee3_758833f70f96
name: GALNT6
constant: false
initial concentration: NaN
type: Species
is: Q8NCL4
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:11226

metaR r1570
reversible: true
kinetic law: MODEL1310110024#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110024#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110024#

metaM 3aib D m
has only substance units: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
type: Species
is: C03265
name: D-3-Amino-isobutanoate
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB02299
initial concentration: 1.0

metaR PIter
type: Reaction
kinetic law: MODEL1310110024#
reversible: true
product: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
reactant: MODEL1310110024#
modifier: MODEL1310110024#
is: SBO:0000185
is described by: ECO:0000212
name: phosphate transport, endoplasmic reticulum

metaM HC01842 c
initial concentration: 1.0
name: Phosphodimethylethanolamine
constant: false
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:31997
boundary condition: false
initial amount: NaN
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)

metaR SPODMm
type: Reaction
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.15.1.1
reactant: MODEL1310110024#
name: superoxide dismutase
fast: false
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (6648.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 2 AUTHORS: PMID:12649272,PMID:9376114 NOTES:TV (8-15-2003)
product: MODEL1310110024#
is described by: ECO:0000304

metaM ribflv c
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB00244
boundary condition: false
is: SBO:0000247
notes: FORMULA: C17H20N4O6 CHARGE: 0
is: C00255
name: Riboflavin
type: Species
initial amount: NaN
is: CHEBI:3554

metaR EX estradiol LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: estradiol exchange
type: Reaction

metaR HISD
is: SBO:0000176
modifier: MODEL1310110024#
product: MODEL1310110024#
is described by: ECO:0000269
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (3034.1) SUBSYSTEM: Histidine metabolism EC Number: 4.3.1.3 Confidence Level: 4 AUTHORS: PMID:8530107 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/4.3.1.3
name: histidase
reversible: false
reactant: MODEL1310110024#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_7794382a_176d_46a0_8e32_22e452b67913
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: B4DDW0
type: Species
name: RDH11
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:51109

metaR r0842
is version of: http://identifiers.org/ec-code/1.3.1.72
name: Postulated transport reaction
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
type: Reaction
reactant: MODEL1310110024#
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110024#
is described by: ECO:0000000
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_b3375aa5_d619_4fe3_a870_a2e66954c1c6
constant: false
is: Q59F77
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5330
boundary condition: true
name: PLCB2
is: SBO:0000252
type: Species

metaR r1571
is: SBO:0000185
product: MODEL1310110024#
kinetic law: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
reactant: MODEL1310110024#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR r0196
is: SBO:0000176
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110024#
type: Reaction
product: MODEL1310110024#
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
modifier: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
is version of: http://identifiers.org/ec-code/3.6.1.5

metaR RPEc
name: ribulose 5-phosphate 3-epimerase
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
reactant: MODEL1310110024#
type: Reaction
reversible: true
kinetic law: MODEL1310110024#
is described by: ECO:0000134
product: MODEL1310110024#

metaR PI345P3P
fast: false
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.67
notes: GENE_ASSOCIATION: (5728.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 4 AUTHORS: PMID:11463863 NOTES:NCD
is: SBO:0000176
product: MODEL1310110024#
type: Reaction
name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_6b9e8b89_a325_4a41_b38b_e96c1cb1f51d
initial concentration: NaN
name: CMAS
is encoded by: hsa:55907
is: Q8NFW8
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_b3a2459e_8f3a_47a0_8b46_b1f478209a35
name: MBOAT7
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:79143
is: Q96N66
has only substance units: false

metaM biocyt m
is: HMDB03134
has only substance units: false
is: C05552
boundary condition: false
initial amount: NaN
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
name: Biocytin
is: http://identifiers.org/pubchem.compound/7886

metaR r0841
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.271
modifier: MODEL1310110024#
reactant: MODEL1310110024#
is: SBO:0000185
fast: false
product: MODEL1310110024#
name: Free diffusion
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16756494 NOTES:
type: Reaction
reversible: true

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

http://identifiers.org/biomodels.db/MODEL1310110024#_0cb04eed_55fd_4131_8da1_ea2e229ffbf1
is: Q16719
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
name: KYNU
is encoded by: hsa:8942
boundary condition: true
has only substance units: false

metaM phyt e
initial concentration: 1.0
name: phytanate
type: Species
is: SBO:0000247
constant: false
is: HMDB00801
has only substance units: false
initial amount: NaN
is: CHEBI:37257
boundary condition: false
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607

http://identifiers.org/biomodels.db/MODEL1310110024#_c015cf52_7a78_4195_81e4_a03d4a910f80
name: _AI761708_1_m
boundary condition: true
has only substance units: false
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AI761708
initial concentration: NaN

metaR FAOXC141C121m
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:1-->C12:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_316966c3_50a2_4561_9026_8cbcddcd5087
type: Species
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10999
name: SLC27A4
is: Q6P1M0
initial concentration: NaN
initial amount: NaN

metaM nadh m
is: SBO:0000247
initial amount: NaN
is: C00004
is: HMDB01487
constant: false
is: CHEBI:57945
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3306
name: Nicotinamide adenine dinucleotide - reduced
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_c247d767_dda0_42af_930d_f2a908bdfe0d
is encoded by: hsa:427
type: Species
name: ASAH1
constant: false
boundary condition: true
is: Q13510
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110024#_5ae2e6eb_b48d_4195_9f66_f64d31f61294
boundary condition: true
is: SBO:0000252
name: SLC24A2
constant: false
type: Species
is encoded by: hsa:25769
initial concentration: NaN
is: Q9UI40
initial amount: NaN
has only substance units: false

metaR GACPAILter
fast: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14517336 NOTES:NCD
product: MODEL1310110024#
reversible: false
name: glucosaminyl-acylphosphatidylinositol ER flippase

metaM 3dphb m
is: HMDB06251
name: 3-Decaprenyl-4-hydroxybenzoate
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C57H85O3 CHARGE: -1 INCHI: InChI=1/C57H86O3/c1-44(2)21-12-22-45(3)23-13-24-46(4)25-14-26-47(5)27-15-28-48(6)29-16-30-49(7)31-17-32-50(8)33-18-34-51(9)35-19-36-52(10)37-20-38-53(11)39-40-54-43-55(57(59)60)41-42-56(54)58/h21,23,25,27,29,31,33,35,37,39,41-43,58H,12-20,22,24,26,28,30,32,34,36,38,40H2,1-11H3,(H,59,60)/b45-23+,46-25+,47-27+,48-29+,49-31+,50-33+,51-35+,52-37+,53-39+
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaM biocyt n
is: C05552
initial amount: NaN
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
name: Biocytin
is: HMDB03134
is: SBO:0000247
type: Species
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/7886
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_e4f398c8_13f2_4e14_94db_5e1497a2185f
is encoded by: hsa:AF116616
name: _AF116616_1_m
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110024#_c74c1628_2012_491f_b983_1205ff473c31
initial amount: NaN
is: SBO:0000252
name: SLCO4A1
boundary condition: true
is: Q96BD0
constant: false
type: Species
is encoded by: hsa:28231
initial concentration: NaN
has only substance units: false

metaM 3mop e
is: CHEBI:28654
name: 3-methyl-2-oxopentanoate
constant: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
is: SBO:0000247
has only substance units: false
is: HMDB00491
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110024#_b1c4e0d7_94e6_4733_ad93_89a09d6c876c
initial concentration: NaN
constant: false
is encoded by: hsa:54995
name: OXSM
type: Species
is: SBO:0000252
is: Q9NWU1
boundary condition: true
initial amount: NaN
has only substance units: false

metaR r1573
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110024#
type: Reaction
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110024#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110024#_7b5cfc6a_60d6_4bd1_afd5_6f1d65ac6241
initial amount: NaN
constant: false
is encoded by: hsa:8818
has only substance units: false
initial concentration: NaN
boundary condition: true
name: DPM2
is: SBO:0000252
type: Species

metaM cs a deg2 l
initial amount: NaN
is: HMDB00127
boundary condition: false
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 2
is: SBO:0000247
notes: FORMULA: C37H55NO38S2 CHARGE: -4
initial concentration: 1.0
is: CHEBI:15748
type: Species
has only substance units: false
constant: false

metaR EX nrpphr LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Norepinephrine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_37ed577d_0d1f_4959_b48f_75fc97f85f82
boundary condition: true
type: Species
is: Q86SR1
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:55568
name: GALNT10
has only substance units: false
constant: false
initial concentration: NaN

metaR SUCD1m
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
name: succinate dehydrogenase
is version of: http://identifiers.org/ec-code/1.3.5.1
product: MODEL1310110024#
fast: false
is: SBO:0000176
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
reversible: true
modifier: MODEL1310110024#
type: Reaction

metaR r1574
is described by: ECO:0000000
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#

metaR ASNtN1
fast: false
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
type: Reaction
name: Asparagine transport (Na, H coupled)
is described by: ECO:0000269
product: MODEL1310110024#
is: SBO:0000185
reactant: MODEL1310110024#
reversible: true
kinetic law: MODEL1310110024#

metaR DCSPTN1CRNt
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
reactant: MODEL1310110024#
is: SBO:0000185
kinetic law: MODEL1310110024#
name: transport into the mitochondria (carnitine)
product: MODEL1310110024#
modifier: MODEL1310110024#
reversible: false

metaR A MANASEly
type: Reaction
reversible: false
is described by: ECO:0000000
name: alpha-mannosidase, lysosomal
reactant: MODEL1310110024#
product: MODEL1310110024#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.24
notes: GENE_ASSOCIATION: (4125.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES:NCD
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#

metaM 10fthf6glu e
constant: false
initial concentration: 1.0
initial amount: NaN
name: 10-formyltetrahydrofolate-[Glu](6)
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1
type: Species
is: CHEBI:58190
is: HMDB00224
boundary condition: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_1545c298_2ebf_4307_867e_e6346f27faf6
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:6548
has only substance units: false
is: SBO:0000252
is: P19634
name: SLC9A1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_b2112871_9ec8_47bf_bed0_a9f78271b047
boundary condition: true
constant: false
name: SLC24A4
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:123041
initial amount: NaN
type: Species

metaM 34dhmald m
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: http://identifiers.org/pubchem.compound/7903
boundary condition: false
name: 3,4-Dihydroxymandelaldehyde
is: SBO:0000247
is: C05577
constant: false
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
is: HMDB06242

metaM dutp c
is: HMDB01191
has only substance units: false
is: C00460
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
name: dUTP
type: Species
is: CHEBI:17625

metaM HC00591 c
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:16769
has only substance units: false
name: 2-oxoglutaramate
initial amount: NaN
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940

metaR HISTAtu
product: MODEL1310110024#
is described by: ECO:0000269
type: Reaction
fast: false
reversible: true
is: SBO:0000185
modifier: MODEL1310110024#
name: Histamine uniport
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
reactant: MODEL1310110024#

metaR PGK
is version of: http://identifiers.org/ec-code/2.7.2.3
is described by: ECO:0000134
is: SBO:0000176
name: phosphoglycerate kinase
reactant: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: (5230.1) or (375056.1) or (5232.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
modifier: MODEL1310110024#
reversible: true
fast: false
kinetic law: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_d276d013_754b_4ed3_afda_a97877fb99ee
is: C9JC79
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6342
has only substance units: false
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
name: SCP2

http://identifiers.org/biomodels.db/MODEL1310110024#_6a0503ab_66a0_44f4_9e99_3ccb2974e8cc
is encoded by: hsa:279
constant: false
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: P04746
initial amount: NaN
name: AMY2A
has only substance units: false

metaR S6T17g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
kinetic law: MODEL1310110024#
is: SBO:0000176
type: Reaction
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000000
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
fast: false

metaR r1575
fast: false
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
product: MODEL1310110024#
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110024#_2b419e90_f313_4ae3_8323_bf01a7d63591
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
constant: false
boundary condition: true
is encoded by: hsa:2271
initial amount: NaN
name: FH
is: P07954

metaR r0990
kinetic law: MODEL1310110024#
type: Reaction
name: Postulated transport reaction
reactant: MODEL1310110024#
is described by: ECO:0000000
reversible: true
product: MODEL1310110024#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110024#_46c5907d_0825_4c0f_abb2_8d2696705892
is encoded by: hsa:1606
boundary condition: true
initial concentration: NaN
is: P23743
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
has only substance units: false
name: DGKA

metaR EX leuktrA4 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene A4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_406ae011_e6b3_4884_ba2a_fbfb96cabb4e
constant: false
name: HCST
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is: Q9UBK5
is encoded by: hsa:10870

http://identifiers.org/biomodels.db/MODEL1310110024#_7da162fc_b70d_4014_845c_0803603d42f5
initial amount: NaN
name: PIGG
type: Species
constant: false
is encoded by: hsa:54872
boundary condition: true
is: Q8NCI4
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaM 3octdectecoa x
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: 3,6,9,12-octadecatetraenoylcoa
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
boundary condition: false
constant: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5280355
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_62989c8c_9c9a_4e27_a9c0_38fc7dafa967
type: Species
is encoded by: hsa:956
constant: false
initial concentration: NaN
is: SBO:0000252
is: O75355
name: ENTPD3
initial amount: NaN
boundary condition: true
has only substance units: false

metaR FAOXC185C164m
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:5-->C16:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_bc56e4bc_9d24_43f4_afb4_360c1b11437c
has only substance units: false
is: Q96QD8
is: SBO:0000252
constant: false
name: SLC38A2
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:54407
boundary condition: true
type: Species

metaR CBASPte
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110024#
is: SBO:0000185
product: MODEL1310110024#
is described by: ECO:0000134
reversible: true
type: Reaction
fast: false
name: Transport of N-carbamoyl-L-aspartate

metaM CE1939 e
has only substance units: false
initial amount: NaN
notes: FORMULA: C7H18N2O CHARGE: 2 INCHI: InChI=1/C7H16N2O/c8-4-1-2-5-9-6-3-7-10/h7,9H,1-6,8H2/p+2 EHMN_ABBREVIATION: CE1939
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:36781
boundary condition: false
constant: false
name: spermidine monoaldehyde 1

metaR r1576
product: MODEL1310110024#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110024#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110024#

metaR FACOAL180i
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
name: C180 fatty acid activation
reversible: false
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (22305.2) or (2181.2) or (51703.1) or (2181.1) or (2180.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
product: MODEL1310110024#
fast: false
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
type: Reaction

metaR FAOXTC102C101m
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C10:2-->C10:1)m
type: Reaction

metaM ha l
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
boundary condition: false
type: Species
is: SBO:0000247
name: hyaluronan
is: CHEBI:16336
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaM 3aib m
name: (S)-3-aminoisobutyric acid
is: HMDB02166
initial amount: NaN
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
is: CHEBI:33094
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247

metaR r0840
name: Free diffusion
fast: false
reversible: true
kinetic law: MODEL1310110024#
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.14.13.70
notes: GENE_ASSOCIATION: (1595.1) or (83530.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110024#
is: SBO:0000185
reactant: MODEL1310110024#

metaM HC01407 m
initial concentration: 1.0
boundary condition: false
is: CHEBI:28276
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268
name: (S)-Hydroxyhexanoyl-CoA

metaR GLCAASE4ly
product: MODEL1310110024#
kinetic law: MODEL1310110024#
name: beta-glucuronidase, lysosomal
is: SBO:0000176
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.2.1.31
is described by: ECO:0000000
reversible: false
fast: false
modifier: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD

metaR NACHEX19ly
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
fast: false
product: MODEL1310110024#
type: Reaction
modifier: MODEL1310110024#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110024#
is: SBO:0000176
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110024#

metaR FAOXC102C103x
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)x
type: Reaction

metaR AG13T8g
fast: false
modifier: MODEL1310110024#
is: SBO:0000176
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
is described by: ECO:0000000
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_8f0673a1_a423_4393_b984_a47b01182f8c
type: Species
boundary condition: true
is: SBO:0000252
name: SLC35B2
constant: false
initial amount: NaN
is encoded by: hsa:347734
has only substance units: false
initial concentration: NaN
is: Q8TB61

metaM HC01609 e
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
name: UroporphyrinogenI
is: CHEBI:28766
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766

metaR TALA
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
fast: false
is version of: http://identifiers.org/ec-code/2.2.1.2
is described by: ECO:0000000
product: MODEL1310110024#
name: transaldolase
is: SBO:0000176
type: Reaction
reversible: true

metaR PGI
name: glucose-6-phosphate isomerase
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
reversible: true
is described by: ECO:0000134
is: SBO:0000176
product: MODEL1310110024#
fast: false
is version of: http://identifiers.org/ec-code/5.3.1.9
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:
type: Reaction

metaR C181CRNt
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110024#
reversible: false
modifier: MODEL1310110024#
reactant: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
name: C181 transport into the mitochondria
kinetic law: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_13e6b241_f01c_4425_996e_5652fb32593f
initial concentration: NaN
is encoded by: hsa:AI935189
is: SBO:0000252
constant: false
type: Species
name: _AI935189_1_m
boundary condition: true
initial amount: NaN
has only substance units: false

metaM bhb m
constant: false
type: Species
name: (R)-3-hydroxybutyrate
is: SBO:0000247
has only substance units: false
is: HMDB00011
initial amount: NaN
is: CHEBI:10983
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
boundary condition: false
initial concentration: 1.0

metaM gua c
type: Species
name: Guanine
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16235
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
is: HMDB00132
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
is: C00242

metaR FAOXC205C185m
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:5-->C18:5)m
type: Reaction

metaR SUCOAS1m
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110024#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.4
name: Succinate--CoA ligase (GDP-forming)
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
fast: false
reversible: true
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#

metaR r0340
is: SBO:0000176
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
modifier: MODEL1310110024#
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.38
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110024#
reversible: false
reactant: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_1881b885_4381_4ab2_b653_74f501015580
boundary condition: true
is: B2RAT6
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:2592
name: GALT
initial concentration: NaN
type: Species
has only substance units: false

metaM C05965 e
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
name: 12(S)-HPETE(1-)
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:57444
is: HMDB04243
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false

metaM CE5236 n
is: CHEBI:28002
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
is: SBO:0000247
type: Species
is: HMDB03952
initial concentration: 1.0
initial amount: NaN
name: O2'-4a-cyclic-tetrahydrobiopterin
boundary condition: false
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_e3878e6b_cc7d_473c_98ca_bbb46fc111cb
is: Q9NY97
initial concentration: NaN
name: B3GNT2
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:10678
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_be053653_4533_4b11_b619_0fc1b64113dd
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q75T13
is encoded by: hsa:80055
type: Species
initial concentration: NaN
has only substance units: false
constant: false
name: PGAP1

metaR GLNtN1
name: Glutamine transport (Na, H coupled)
reversible: true
modifier: MODEL1310110024#
is described by: ECO:0000269
product: MODEL1310110024#
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
reactant: MODEL1310110024#
type: Reaction
fast: false
is: SBO:0000185

metaM nadh r
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:57945
boundary condition: false
is: HMDB01487
name: NADH(2-)
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
constant: false

metaM 2dpmhobq m
initial amount: NaN
constant: false
name: 2-decaprenyl-5-hydroxy-6-methoxy-3-methyl-1,4-benzoquinone
is: HMDB06484
notes: FORMULA: C58H88O4 CHARGE: 0 INCHI: InChI=1S/C58H88O4/c1-43(2)23-14-24-44(3)25-15-26-45(4)27-16-28-46(5)29-17-30-47(6)31-18-32-48(7)33-19-34-49(8)35-20-36-50(9)37-21-38-51(10)39-22-40-52(11)41-42-54-53(12)55(59)57(61)58(62-13)56(54)60/h23,25,27,29,31,33,35,37,39,41,61H,14-22,24,26,28,30,32,34,36,38,40,42H2,1-13H3/b44-25+,45-27+,46-29+,47-31+,48-33+,49-35+,50-37+,51-39+,52-41+
initial concentration: 1.0
has only substance units: false
is: CHEBI:50771
is: SBO:0000247
type: Species
boundary condition: false

metaM nadp m
is: HMDB00217
has only substance units: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
initial concentration: 1.0
type: Species
name: Nicotinamide adenine dinucleotide phosphate
is: CHEBI:58349
constant: false
initial amount: NaN
boundary condition: false
is: C00006
is: SBO:0000247

metaR r0995
kinetic law: MODEL1310110024#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
is described by: ECO:0000000
reactant: MODEL1310110024#
fast: false
product: MODEL1310110024#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:

metaM thmpp m
notes: FORMULA: C12H16N4O7P2S CHARGE: -2 INCHI: InChI=1S/C12H18N4O7P2S/c1-8-11(3-4-22-25(20,21)23-24(17,18)19)26-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H4-,13,14,15,17,18,19,20,21) HEPATONET_1.0_ABBREVIATION: HC00071 EHMN_ABBREVIATION: C00068
constant: false
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
name: Thiamine diphosphate
has only substance units: false
is: HMDB01372
initial concentration: 1.0
is: CHEBI:45931

http://identifiers.org/biomodels.db/MODEL1310110024#_67473320_0bb0_4005_98a5_faa41afc3d0e
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:206358
is: Q1LZ56
type: Species
name: SLC36A1
initial amount: NaN
has only substance units: false

metaR DOLPMT2 Uer
reversible: false
is described by: ECO:0000000
fast: false
product: MODEL1310110024#
kinetic law: MODEL1310110024#
type: Reaction
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176

metaR CYTDK1
type: Reaction
is described by: ECO:0000254
fast: false
name: ATPcytidine 5-phosphotransferase
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 2 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.48
reversible: false
modifier: MODEL1310110024#
is: SBO:0000176
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
product: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_61de6fb2_1013_4a17_8111_90a0e63acabc
has only substance units: false
is encoded by: hsa:23556
is: O95427
type: Species
boundary condition: true
initial amount: NaN
name: PIGN
initial concentration: NaN
constant: false
is: SBO:0000252

metaR BAAT1x
is version of: http://identifiers.org/ec-code/2.3.1.65
reversible: false
reactant: MODEL1310110024#
product: MODEL1310110024#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110024#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
modifier: MODEL1310110024#
name: bile acid Coenzyme A: amino acid N-acyltransferase

http://identifiers.org/biomodels.db/MODEL1310110024#_941a8e84_38c7_42a5_ab28_1137a8164a90
type: Species
is: Q5JWV8
initial amount: NaN
boundary condition: true
is encoded by: hsa:2182
is: SBO:0000252
name: ACSL4
initial concentration: NaN
constant: false
has only substance units: false

metaM biliverd c
is: CHEBI:57991
boundary condition: false
notes: FORMULA: C33H32N4O6 CHARGE: -2 INCHI: InChI=1S/C33H34N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-15,35H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14-,28-15- EHMN_ABBREVIATION: C00500
has only substance units: false
type: Species
initial concentration: 1.0
name: biliverdin(2-)
is: HMDB01008
constant: false
initial amount: NaN
is: SBO:0000247

metaR r1683
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
modifier: MODEL1310110024#
fast: false
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110024#

metaR RE0583C
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
name: RE0583
reversible: true
product: MODEL1310110024#
fast: false
reactant: MODEL1310110024#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110024#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110024#_400fe9b4_0949_415a_987e_804dc00c539e
initial amount: NaN
boundary condition: true
is encoded by: hsa:7991
type: Species
initial concentration: NaN
name: TUSC3
has only substance units: false
constant: false
is: SBO:0000252

metaM 3aib D c
initial amount: NaN
boundary condition: false
is: HMDB02299
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
name: D-3-Amino-isobutanoate
is: C03265
is: SBO:0000247
type: Species

metaM biocyt e
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
initial concentration: 1.0
name: Biocytin
has only substance units: false
is: SBO:0000247
is: C05552
is: http://identifiers.org/pubchem.compound/7886
is: HMDB03134
initial amount: NaN
type: Species
constant: false
boundary condition: false

metaR S6T8g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110024#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#

metaM nadh x
boundary condition: false
is: CHEBI:57945
constant: false
initial concentration: 1.0
is: C00004
is: HMDB01487
name: Nicotinamide adenine dinucleotide - reduced
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3306
initial amount: NaN
type: Species
has only substance units: false

metaR r0994
reversible: true
name: Facilitated diffusion
reactant: MODEL1310110024#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
fast: false
kinetic law: MODEL1310110024#
is: SBO:0000185
product: MODEL1310110024#
type: Reaction

metaR 2DR1PP
product: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.10 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
reversible: false
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110024#
type: Reaction
name: 2-deoxy-D-ribose 1-phosphate phosphorylase
kinetic law: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_9fa65d0c_7120_469b_b9b1_950572277cfa
initial amount: NaN
constant: false
name: EHHADH
type: Species
is: Q9NY65
boundary condition: true
has only substance units: false
is encoded by: hsa:1962
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_c41fc050_d693_4359_a32b_d56b7f81308e
type: Species
is encoded by: hsa:771
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: CA12

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

metaM gua e
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
is: HMDB00132
name: guanine
is: CHEBI:16235

metaR APRGSTRNte
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110024#
name: hydroxyprogesterone transport
is: SBO:0000185
reversible: true
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
reactant: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_f022e603_4f1a_4fc5_96fc_b4528de1d21d
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:271
has only substance units: false
is: Q01433
name: AMPD2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_3f26ab73_eb30_411f_ab95_544e42bf56c5
is encoded by: hsa:64902
is: Q9BYV1
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
name: AGXT2

metaM estradiol e
type: Species
is: SBO:0000247
is: CHEBI:16469
initial concentration: 1.0
name: estradiol
initial amount: NaN
constant: false
has only substance units: false
is: HMDB00151
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
boundary condition: false

metaR r0450
modifier: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.3
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
kinetic law: MODEL1310110024#
reversible: true
is: SBO:0000176
reactant: MODEL1310110024#
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39

http://identifiers.org/biomodels.db/MODEL1310110024#_5a8b8fbb_e129_4e5e_8f19_8e7eb9cdbb51
boundary condition: true
is encoded by: hsa:NM 013421
has only substance units: false
name: _NM_013421_1_m
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_9ec16444_f4b9_4675_8ec8_91c24285b84a
initial amount: NaN
is: Q14642
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
name: INPP5A
is encoded by: hsa:3632
constant: false
initial concentration: NaN

metaM pail3p hs c
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
constant: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C04549
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:58088
type: Species
has only substance units: false

metaR ORPT
product: MODEL1310110024#
is: SBO:0000176
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.10
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.4.2.10 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
modifier: MODEL1310110024#
name: orotate phosphoribosyltransferase
fast: false
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
type: Reaction

metaM 3mop m
is: CHEBI:28654
boundary condition: false
name: 3-methyl-2-oxopentanoate
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
initial amount: NaN
is: HMDB00491
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110024#_88c1e470_a761_478a_8c31_a345697c3245
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
type: Species
name: SI
is: P14410
initial amount: NaN
is encoded by: hsa:6476
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110024#_e27223ce_9934_448c_a426_ec8196f317be
name: _AI345944_1_m
type: Species
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AI345944

http://identifiers.org/biomodels.db/MODEL1310110024#_e37d2e1f_2f39_4790_830a_cb92f6887596
name: SLC7A8
type: Species
is: Q86U05
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:23428
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaM HC01459 x
is: CHEBI:27458
boundary condition: false
initial amount: NaN
notes: FORMULA: C48H76N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-34,36,38-40,44,56-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/t24-,25?,26+,27-,28-,29+,30+,31?,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 EHMN_ABBREVIATION: C05450
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
name: 3alpha,7alpha,12alpha,24-Tetrahydroxy-5beta-cholestanoyl-CoA
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_9d7d3694_94bf_4b47_bce5_ed0b5efdc0eb
name: MANBA
type: Species
initial amount: NaN
is: O00462
is: SBO:0000252
is encoded by: hsa:4126
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN

metaM succoa x
initial amount: NaN
constant: false
name: Succinyl-CoA
is: HMDB01022
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C25H35N7O19P3S CHARGE: -5

metaR GLCAASE7ly
is version of: http://identifiers.org/ec-code/3.2.1.31
is described by: ECO:0000000
name: beta-glucuronidase, lysosomal
kinetic law: MODEL1310110024#
fast: false
type: Reaction
reversible: false
reactant: MODEL1310110024#
is: SBO:0000176
modifier: MODEL1310110024#
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaM stcrn m
boundary condition: false
name: stearoylcarnitine
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C25H49NO4 CHARGE: 0 INCHI: InChI=1/C25H49NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h23H,5-22H2,1-4H3
has only substance units: false
constant: false
is: HMDB00848
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_7aac3b34_97fb_4829_b4c5_37e457ce839a
is encoded by: hsa:57835
type: Species
has only substance units: false
name: SLC4A5
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN

metaR r1686
modifier: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
name: Y+LAT2 Utilized transport
fast: false
is described by: ECO:0000000
reactant: MODEL1310110024#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
kinetic law: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_4ec49c1f_a68f_47d4_ad4d_3d8b4928df23
initial concentration: NaN
is encoded by: hsa:353
initial amount: NaN
has only substance units: false
type: Species
is: P07741
boundary condition: true
name: APRT
is: SBO:0000252
constant: false

metaM bhb c
initial amount: NaN
initial concentration: 1.0
name: (R)-3-hydroxybutyrate
is: CHEBI:10983
is: SBO:0000247
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
constant: false
boundary condition: false
has only substance units: false
type: Species
is: HMDB00011

metaR r0999
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is described by: ECO:0000000
reversible: true
name: Facilitated diffusion
kinetic law: MODEL1310110024#
type: Reaction
reactant: MODEL1310110024#
fast: false
product: MODEL1310110024#

metaM itacon m
boundary condition: false
initial concentration: 1.0
is: CHEBI:17240
name: itaconate(2-)
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB02092
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
has only substance units: false
type: Species

metaR MG1er
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (7841.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.106 Confidence Level: 0 AUTHORS: NOTES:NCD
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
is described by: ECO:0000000
is: SBO:0000176
fast: false
modifier: MODEL1310110024#
reactant: MODEL1310110024#
product: MODEL1310110024#
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.2.1.106

MODEL1310110024
reaction: metaR FAOXC101m
species: metaM cytd c
species: metaM CE5125 x
species: metaM tyr L c
reaction: metaR MG2er
reaction: metaR CITtam
reaction: metaR r1633
species: metaM arg L c
reaction: metaR FAOXC163C164x
reaction: metaR FUCASE2ly
reaction: metaR EX acnacngalgbside hs LPAREN e RPAREN
species: metaM fuc1p L c
species: metaM gchola e
reaction: metaR r2346
reaction: metaR EX idour LPAREN e RPAREN
reaction: metaR RTOTAL2t
species: metaM pheacgln c
reaction: metaR EX tyr L LPAREN e RPAREN
reaction: metaR r1631
reaction: metaR VALtec
reaction: metaR ABTti
reaction: metaR r2373
species: metaM lald D c
reaction: metaR N3Tg
reaction: metaR r1148
species: metaM pail hs c
reaction: metaR r0330
reaction: metaR r2101
reaction: metaR 3SALAASPm
reaction: metaR S3TASE2ly
species: metaM hs deg8 l
species: metaM 10fthf7glu e
reaction: metaR FUMSO3tm
reaction: metaR RETI2
reaction: metaR CYSSNAT5tc
reaction: metaR THRASNNaEx
species: metaM dece4coa m
species: metaM leu L c
species: metaM 3dsphgn c
reaction: metaR EHGLATm
species: metaM xyl D l
species: metaM xoldiolone r
reaction: metaR S6T12g
reaction: metaR FAOXC142C122m
species: metaM HC02187 c
species: metaM gacpail hs c
reaction: metaR G14Tg
species: metaM dmnoncoa c
reaction: metaR PUNP3
species: metaM HC01603 c
reaction: metaR TYROXDAc
species: metaM dgdp c
species: metaM ksi deg8 l
reaction: metaR DAGt
reaction: metaR r0009
species: metaM pchol hs m
reaction: metaR FOLt2le
reaction: metaR OLEICFATPtc
reaction: metaR 13DAMPPOX
reaction: metaR UMPK6
reaction: metaR ENGASEly
reaction: metaR FACOAL204
species: metaM ins c
species: metaM 3mox4hpac m
species: metaM acnam c
reaction: metaR NDPK7
species: metaM glcur e
species: metaM ksi pre28 g
reaction: metaR DECDPtm
reaction: metaR 4NPHSULT
species: metaM eicostetcrn c
reaction: metaR ICDHyrm
species: metaM malthx e
reaction: metaR S2TASE3ly
reaction: metaR r1603
reaction: metaR FAOXC6DCC4DCx
species: metaM gdp g
reaction: metaR CTPS1
species: metaM betald c
reaction: metaR r2516

metaM estradiol c
name: estradiol
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB00151
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16469
type: Species

metaM ile L m
has only substance units: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
boundary condition: false
is: SBO:0000247
type: Species
name: L-isoleucine
constant: false
initial concentration: 1.0
is: CHEBI:17191
is: HMDB00172
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_fd037168_bd31_4d79_99bc_cc3b246303c4
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:T83654
name: _T83654_1_e

metaM CE5236 c
type: Species
name: O2'-4a-cyclic-tetrahydrobiopterin
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:28002
initial concentration: 1.0
is: HMDB03952
is: SBO:0000247
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110024#_dd1aecc0_33d8_46d8_8951_0efa8ffde23f
name: _N63787_1_c
initial concentration: NaN
is encoded by: hsa:N63787
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false

metaR THYMDtm
reactant: MODEL1310110024#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110024#
fast: false
reversible: true
name: thymd transport
is: SBO:0000185
kinetic law: MODEL1310110024#
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:TDV

metaM 3aib c
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: (S)-3-aminoisobutyric acid
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
is: CHEBI:33094
is: SBO:0000247
is: HMDB02166

http://identifiers.org/biomodels.db/MODEL1310110024#_596e0349_1fc4_4706_abcd_17ff75583a3a
initial concentration: NaN
name: NDUFS5
has only substance units: false
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:4725
boundary condition: true
is: SBO:0000252
is: Q6IBA0

metaR TMDK1m
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.21
reversible: false
is: SBO:0000176
product: MODEL1310110024#
reactant: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 4 AUTHORS: PMID:12535661,PMID:9342341 NOTES:TV
name: thymidine kinase (ATP:thymidine)
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#

metaR THMP
product: MODEL1310110024#
is described by: ECO:0000000
kinetic law: MODEL1310110024#
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110024#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:11997266,PMID:8522961 NOTES:EC 3.1.3.- NCD
name: thiamin phosphatase

metaR EX ahcys LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of S-adenosyl-L-homocysteine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_0493313b_2346_4fde_acb9_23165dc4aa1a
has only substance units: false
is encoded by: hsa:79017
boundary condition: true
type: Species
is: SBO:0000252
name: GGCT
is: B8ZZR8
initial concentration: NaN
constant: false
initial amount: NaN

metaR r0998
product: MODEL1310110024#
is described by: ECO:0000000
kinetic law: MODEL1310110024#
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
name: Facilitated diffusion
reactant: MODEL1310110024#
fast: false

metaM nadp r
type: Species
boundary condition: false
is: C00006
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58349
is: SBO:0000247
has only substance units: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: HMDB00217
name: Nicotinamide adenine dinucleotide phosphate

metaR FAOXC102C103m
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)m
type: Reaction

metaR RE0915E
is: SBO:0000176
reactant: MODEL1310110024#
product: MODEL1310110024#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.1
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.2.1.17
reversible: true
type: Reaction
name: RE0915
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110024#_b38c1892_45e7_4426_b23a_1ee06021ba0d
name: PHPT1
is encoded by: hsa:29085
type: Species
has only substance units: false
is: Q9P019
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaM 5pmev x
has only substance units: false
name: (R)-5-phosphonatomevalonate(3-)
notes: FORMULA: C6H10O7P CHARGE: -3 INCHI: InChI=1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/p-3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00670 EHMN_ABBREVIATION: C01107
initial amount: NaN
is: HMDB01343
boundary condition: false
constant: false
type: Species
is: CHEBI:58146
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110024#_06e6aa3b_db8d_478d_aae3_eb7c42438936
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:80339
initial amount: NaN
constant: false
is: Q9NST1
initial concentration: NaN
name: PNPLA3
has only substance units: false

metaM arachd x
type: Species
is: HMDB01043
initial amount: NaN
is: SBO:0000247
is: CHEBI:32395
name: arachidonate
constant: false
initial concentration: 1.0
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
has only substance units: false
boundary condition: false

metaR FADDPle
notes: GENE_ASSOCIATION: (5167.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110024#
is: SBO:0000176
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.1.4.1
type: Reaction
fast: false
name: FAD diphosphatase
kinetic law: MODEL1310110024#
reversible: false
is described by: ECO:0000134
modifier: MODEL1310110024#

metaM bhb e
is: SBO:0000247
is: CHEBI:10983
constant: false
initial concentration: 1.0
name: (R)-3-hydroxybutyrate
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
type: Species
boundary condition: false
is: HMDB00011
has only substance units: false
initial amount: NaN

metaR UDPGLCAter
reversible: true
is: SBO:0000185
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
fast: false
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110024#

metaM ribflv e
name: Riboflavin
initial amount: NaN
is: C00255
is: CHEBI:3554
type: Species
is: HMDB00244
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C17H20N4O6 CHARGE: 0
constant: false
boundary condition: false

metaM man1p c
is: HMDB06330
initial amount: NaN
is: CHEBI:35374
type: Species
constant: false
name: D-Mannose 1-phosphate
has only substance units: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaM dectricoa x
notes: FORMULA: C31H44N7O17P3S CHARGE: -4
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966
boundary condition: false
initial concentration: 1.0
constant: false
name: 2,4,7-decatrienoylcoa
is: SBO:0000247
has only substance units: false

metaR AG13T18g
is: SBO:0000176
fast: false
kinetic law: MODEL1310110024#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
product: MODEL1310110024#
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
is described by: ECO:0000000
reversible: false

metaR RE3003M
modifier: MODEL1310110024#
is: SBO:0000176
reversible: true
fast: false
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE3003
is version of: http://identifiers.org/ec-code/5.3.3.8
product: MODEL1310110024#
type: Reaction
reactant: MODEL1310110024#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110024#_28894463_8609_40ed_8a1c_097fc8331eb2
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
name: ALDH1A2
boundary condition: true
is: B4DZR2
constant: false
has only substance units: false
is encoded by: hsa:8854

metaM HC00591 m
has only substance units: false
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
initial concentration: 1.0
constant: false
is: CHEBI:16769
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
name: 2-oxoglutaramate

metaM 3aib e
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:33094
initial concentration: 1.0
type: Species
name: (S)-3-aminoisobutyric acid
is: SBO:0000247
has only substance units: false
is: HMDB02166
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284

metaR M4MPDOL Lter
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
reversible: false
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: m4mpdol flippase
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
product: MODEL1310110024#

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

metaM mgacpail hs r
initial concentration: 1.0
is: C00249
name: mannosyl-glucosaminyl-acylphosphatidylinositiol (H2)
initial amount: NaN
is: CHEBI:7896
constant: false
has only substance units: false
notes: FORMULA: C37H68NO19PFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
is: SBO:0000247
is: HMDB00220
type: Species

metaR EX 34hpp
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_4c181b76_f639_4393_9955_395faded48f1
constant: false
boundary condition: true
is: SBO:0000252
type: Species
name: PANK2
is encoded by: hsa:80025
initial concentration: NaN
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_115ccf76_ce34_4d24_a009_3c8bf548159e
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4833
is: O00746
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
name: NME4

http://identifiers.org/biomodels.db/MODEL1310110024#_fdb0f67c_9457_4758_a7df_bb56f10f208f
type: Species
has only substance units: false
initial concentration: NaN
name: ATP1A3:ATP1B2
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000297
is encoded by: hsa:482
has part: P14415

metaM ksi pre30 g
boundary condition: false
notes: FORMULA: C219H350N15O184S9X CHARGE: -10
type: Species
is: CHEBI:58053
initial amount: NaN
is: C00130
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 30
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_b0136636_5e7b_4ef0_97a2_fdb545903a3e
initial concentration: NaN
is: P30838
boundary condition: true
type: Species
is encoded by: hsa:218
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
name: ALDH3A1

http://identifiers.org/biomodels.db/MODEL1310110024#_acf1b778_6175_4889_9c68_7d9e7ec3a599
is encoded by: hsa:160851
has only substance units: false
initial concentration: NaN
type: Species
name: DGKH
constant: false
initial amount: NaN
is: SBO:0000252
is: Q86XP1
boundary condition: true

metaR r1682
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110024#
fast: false
reactant: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110024#
modifier: MODEL1310110024#
name: Y+LAT2 Utilized transport

metaR EX paf hs LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-acteylglycerol 3-phosphocholine (homo sapiens) exchange
type: Reaction

metaM dd2coa m
type: Species
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
is: CHEBI:57330
name: trans-dodec-2-enoyl-CoA(4-)
is: HMDB03712
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110024#_873e5f91_84c7_4182_a665_d948d4d7cfe9
constant: false
is: P48507
has only substance units: false
name: GCLM
is encoded by: hsa:2730
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species

metaM leuktrB4 c
is: SBO:0000247
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
is: HMDB01085
name: leukotriene B4(1-)
has only substance units: false
is: CHEBI:57461
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaM m4mpdol U c
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
has only substance units: false
constant: false
is: CHEBI:37633
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110024#_e02fe41c_78a3_47d8_ab4f_af4f5f5f867b
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
name: PRPS1L1
type: Species
is: SBO:0000252
is encoded by: hsa:221823
initial concentration: NaN

metaR HDCAtr
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110024#
is: SBO:0000185

metaM ksi deg4 l
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:57737
name: keratan sulfate I, degradation product 4
has only substance units: false
type: Species
is: HMDB00868
notes: FORMULA: C222H355N15O197S12 CHARGE: -12

http://identifiers.org/biomodels.db/MODEL1310110024#_64ed4d9d_5aa7_495e_8984_5f2cadb39aec
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:56623
is: Q9NRR6
name: INPP5E
has only substance units: false
initial concentration: NaN
constant: false

metaM so4 l
initial concentration: 1.0
is: HMDB01448
type: Species
name: sulfate
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:16189
has only substance units: false
initial amount: NaN

metaR r2368
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
is: SBO:0000185
reversible: true
product: MODEL1310110024#
reactant: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
kinetic law: MODEL1310110024#

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

metaM hestratriol r
has only substance units: false
initial concentration: 1.0
is: HMDB05896
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
type: Species
name: 4,17 dihydroxy estradiol
boundary condition: false

metaM crm hs e
initial amount: NaN
name: N-acylsphingosine
type: Species
is: CHEBI:52639
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
boundary condition: false

metaR r1260
product: MODEL1310110024#
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is described by: ECO:0000000
reversible: false
fast: false
is: SBO:0000176
reactant: MODEL1310110024#
name: EC:6.2.1.3
type: Reaction

metaM gln L c
is: HMDB00641
initial amount: NaN
is: CHEBI:18050
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
name: L-glutamine
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110024#_9e7b5010_1254_40d4_8608_b52969134bae
is encoded by: hsa:23556
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
name: PIGN
has only substance units: false
boundary condition: true

metaR P45027A14m
product: MODEL1310110024#
name: 5-beta-cytochrome P450, family 27, subfamily A, polypeptide 1
reversible: false
reactant: MODEL1310110024#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.13.15
fast: false

metaR GAL3ST11
product: MODEL1310110024#
kinetic law: MODEL1310110024#
name: Galactosylceramide sulfotransferase
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (9514.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 4 AUTHORS: PMID:9030544 NOTES:NJ
is described by: ECO:0000000
fast: false
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.8.2.11
modifier: MODEL1310110024#
is: SBO:0000176

metaM ksii core2 deg2 l
name: keratan sulfate II (core 2-linked), degradation product 2
is: HMDB00143
initial amount: NaN
is: CHEBI:12936
constant: false
notes: FORMULA: C70H114N5O56S2X CHARGE: -2
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species

metaM gdp g
is: SBO:0000247
type: Species
name: GDP(3-)
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB01201
initial concentration: 1.0
constant: false
is: CHEBI:58189

http://identifiers.org/biomodels.db/MODEL1310110024#_f5c1ca6f_aa7e_4c74_a509_82c0a8c3918f
is: Q5TDP6
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:51557
name: LGSN

metaR OCDCAtr
is: SBO:0000185
reversible: true
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
name: fatty acid transport via diffusion
kinetic law: MODEL1310110024#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_5aa519df_1f23_4633_859a_6241d849ae13
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is: P19961
name: AMY2B
is encoded by: hsa:280
boundary condition: true
constant: false

metaR GALASE20ly
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110024#
type: Reaction
name: beta-galactosidase, lysosomal
kinetic law: MODEL1310110024#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110024#

metaM 4izp c
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H7N2O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01157 EHMN_ABBREVIATION: C03680
initial concentration: 1.0
type: Species
is: CHEBI:57255
constant: false
name: 4-Imidazolone-5-propanoate
boundary condition: false
is: HMDB01014

metaR MTHFDm
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
is version of: http://identifiers.org/ec-code/6.3.4.3
is: SBO:0000176
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
is version of: http://identifiers.org/ec-code/3.5.4.9
kinetic law: MODEL1310110024#
type: Reaction
reactant: MODEL1310110024#
is described by: ECO:0000269
fast: false
reversible: true
modifier: MODEL1310110024#
product: MODEL1310110024#

metaR r0434
is: SBO:0000176
reversible: true
product: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
reactant: MODEL1310110024#
is described by: ECO:0000000
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
fast: false
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#

metaR EX spmd LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of spermidine(3+)
type: Reaction

metaR r2369
kinetic law: MODEL1310110024#
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
type: Reaction
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000000
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110024#_d00d372f_5e3a_4ef2_ae5b_736de3dfc6c3
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false
initial amount: NaN
is: Q8TE04
name: PANK1
is encoded by: hsa:53354
is: SBO:0000252

metaR GALASE13ly
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
reversible: false
type: Reaction
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: beta-galactosidase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110024#_0d136800_655f_4a83_a11c_737fff569ae6
is: SBO:0000252
name: GCNT1
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2650
has only substance units: false
is: Q02742
constant: false

W3 CDTF: Thu Aug 30 19:37:46 BST 2012

metaR SERPT
modifier: MODEL1310110024#
fast: false
reversible: false
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (10558.1 and 9517.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.3.1.50 Confidence Level: 4 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/2.3.1.50
type: Reaction
name: serine C-palmitoyltransferase
product: MODEL1310110024#
is: SBO:0000176
kinetic law: MODEL1310110024#
is described by: ECO:0000269

metaM gln L e
is: CHEBI:18050
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: SBO:0000247
name: L-glutamine
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB00641
initial concentration: 1.0
type: Species
constant: false

metaR r1117
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17124168 NOTES:
reactant: MODEL1310110024#
is: SBO:0000185
kinetic law: MODEL1310110024#
fast: false
product: MODEL1310110024#
name: Facilitated diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_b6d92c5f_10a7_4f8b_a9fa_22b19d443c08
name: _MBOAT5_1_c
is: SBO:0000252
has only substance units: false
is encoded by: hsa:MBOAT5
constant: false
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN

metaR DHFtm
name: dihydrofolate reversible mitochondrial transport
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
fast: false

metaM crm hs g
type: Species
is: CHEBI:52639
name: N-acylsphingosine
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195

metaM 3dsphgn c
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:58299
has only substance units: false
is: HMDB01480
name: (2S)-1-hydroxy-3-oxooctadecan-2-aminium
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17,20H,2-16,19H2,1H3/p+1/t17-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01019 EHMN_ABBREVIATION: C02934

metaR r1262
reactant: MODEL1310110024#
is described by: ECO:0000000
product: MODEL1310110024#
is: SBO:0000176
name: EC:6.2.1.3
kinetic law: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
fast: false
reversible: false

metaR SADT
is: SBO:0000176
reversible: false
modifier: MODEL1310110024#
type: Reaction
name: sulfate adenylyltransferase
is version of: http://identifiers.org/ec-code/2.7.1.25
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
kinetic law: MODEL1310110024#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110024#
product: MODEL1310110024#

metaM hspg l
is: CHEBI:17899
initial concentration: 1.0
is: HMDB01993
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
name: heparan sulfate proteoglycan
constant: false
boundary condition: false
notes: FORMULA: C79H113N5O101S12X CHARGE: -13

metaM 5forthf c
is: SBO:0000247
type: Species
constant: false
name: 5-Formiminotetrahydrofolate
is: C00664
is: HMDB01534
boundary condition: false
is: CHEBI:57456
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C20H22N8O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00483 EHMN_ABBREVIATION: C00664
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_cbff538c_7979_456d_9b8b_d2c4aa7d9bbb
initial concentration: NaN
boundary condition: true
type: Species
name: DGKI
constant: false
is encoded by: hsa:9162
is: O75912
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaM m3mpdol U c
boundary condition: false
name: (alpha-D-mannosyl)3-beta-D-mannosyl-diacetylchitodiphosphodolichol, human uterine homolog
initial concentration: 1.0
type: Species
is: CHEBI:37632
constant: false
notes: FORMULA: C1425H2340N20O370P20 CHARGE: -20
is: SBO:0000247
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_178858ad_0533_4e51_906e_cbea37e32e4b
initial concentration: NaN
constant: false
is: SBO:0000252
name: _AU149534_1_m
type: Species
has only substance units: false
is encoded by: hsa:AU149534
initial amount: NaN
boundary condition: true

metaR LEUKTRE4t
product: MODEL1310110024#
type: Reaction
reactant: MODEL1310110024#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: leukotriene E4 transport
reversible: true
is described by: ECO:0000000

metaM gdp e
name: GDP(3-)
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01201
is: CHEBI:58189
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_1f13ad48_33eb_412c_a1f7_a295d20695eb
name: HMOX1
is encoded by: hsa:3162
is: Q6FH11
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false

metaM so4 m
is: HMDB01448
boundary condition: false
is: CHEBI:16189
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
type: Species
name: sulfate
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaR r1116
reactant: MODEL1310110024#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110024#
fast: false
product: MODEL1310110024#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:
reversible: true
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1

metaR GLCNACASE1ly
reactant: MODEL1310110024#
type: Reaction
kinetic law: MODEL1310110024#
product: MODEL1310110024#
modifier: MODEL1310110024#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.50
name: alpha-N-acetylglucosaminidase, lysosomal
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110024#_79c107fc_8604_42a8_b10b_a3e2368a63b4
type: Species
name: RPIA
has only substance units: false
is: P49247
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:22934
is: SBO:0000252
boundary condition: true

metaR ASNTHRNaEx
reactant: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
modifier: MODEL1310110024#
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reversible: false
name: L-threonine/L-asparagine Na-dependent exchange (Asn-L in)

metaM air c
notes: FORMULA: C8H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01108 EHMN_ABBREVIATION: C03373
initial amount: NaN
boundary condition: false
is: CHEBI:58592
is: HMDB01235
has only substance units: false
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole
is: C03373

metaR RE1447N
type: Reaction
reversible: true
product: MODEL1310110024#
name: RE1447
reactant: MODEL1310110024#
fast: false
kinetic law: MODEL1310110024#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
is: SBO:0000176

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

metaR LNLNCGt
kinetic law: MODEL1310110024#
product: MODEL1310110024#
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
reactant: MODEL1310110024#
name: fatty acid transport via diffusion
reversible: true

metaM biocyt c
is: http://identifiers.org/pubchem.compound/7886
has only substance units: false
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
boundary condition: false
initial amount: NaN
is: C05552
constant: false
initial concentration: 1.0
type: Species
is: HMDB03134
is: SBO:0000247
name: Biocytin

http://identifiers.org/biomodels.db/MODEL1310110024#_ec90f237_96dd_48a6_aeb8_ceded1fdf428
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:NOS2A
name: _NOS2A_1_e
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_e4497cea_2bf2_43f8_9cd4_08adddde57cb
has only substance units: false
is: Q5TEK5
boundary condition: true
name: PDE4B
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:5142

http://identifiers.org/biomodels.db/MODEL1310110024#_9cabb53b_c6d2_44f8_b28c_f4df12ae4af0
boundary condition: true
is encoded by: hsa:23439
type: Species
initial concentration: NaN
is: SBO:0000297
has part: Q9UN42
initial amount: NaN
has only substance units: false
constant: false
has part: P50993
name: ATP1B4:ATP1A2
is encoded by: hsa:477

http://identifiers.org/biomodels.db/MODEL1310110024#_92dcfa0f_0893_4cba_ba91_306b265a87c3
type: Species
has only substance units: false
constant: false
is encoded by: hsa:R51273
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: _R51273_1_c
boundary condition: true

metaM dcholcoa r
constant: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
initial concentration: 1.0
name: chenodeoxycholoyl coenzyme a
has only substance units: false
is: SBO:0000247
is: HMDB06292
type: Species
is: CHEBI:28701
initial amount: NaN
boundary condition: false

metaR RE1447M
reactant: MODEL1310110024#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.41
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
type: Reaction
modifier: MODEL1310110024#
is described by: ECO:0000000
product: MODEL1310110024#
name: RE1447
kinetic law: MODEL1310110024#
is: SBO:0000176

metaM g1m8masn r
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C76H127N2O60X CHARGE: 0
name: (alpha-D-Glucosyl)-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
constant: false
type: Species
is: C05875

metaR EX txa2 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thromboxane A2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_74a251ed_2191_4038_83a2_4e76d15d3112
is encoded by: hsa:91734
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: Q9BXS1
name: IDI2
type: Species
boundary condition: true
constant: false
has only substance units: false

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

metaM hs deg14 l
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: heparan sulfate, degradation product 14
initial concentration: 1.0
notes: FORMULA: C57H84N3O62S5 CHARGE: -7
type: Species
is: CHEBI:16126
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_8a29f2b9_cf49_42f4_a8b7_77e0019ab399
is: P14618
initial amount: NaN
is encoded by: hsa:5315
initial concentration: NaN
type: Species
name: PKM2
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110024#_3709f96c_6eb6_48d9_a480_82d4d0f89759
constant: false
boundary condition: true
has only substance units: false
is: Q7Z725
initial amount: NaN
is: SBO:0000252
name: SLC34A1
type: Species
initial concentration: NaN
is encoded by: hsa:6569

metaM tddedi2coa m
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
boundary condition: false
is: HMDB00672
initial concentration: 1.0
initial amount: NaN
constant: false
is: C08260
name: trans2,6dodecadienoylcoa
has only substance units: false
type: Species
is: SBO:0000247

metaM dc2coa m
name: trans-Dec-2-enoyl-CoA
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275
type: Species
initial amount: NaN
is: CHEBI:61406
constant: false

metaR KSII CORE2tly
product: MODEL1310110024#
fast: false
is described by: ECO:0000000
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: keratan sulfate II (core 2) transport, extracellular to lysosome
reactant: MODEL1310110024#
type: Reaction
kinetic law: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_ec21cdf6_b7cf_499c_81f8_a385d4c15298
is: Q59HH3
boundary condition: true
is encoded by: hsa:2618
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
name: GART

http://identifiers.org/biomodels.db/MODEL1310110024#_c05fcb36_7d83_4347_bc34_f2cb1a9adee0
constant: false
is encoded by: hsa:57026
name: PDXP
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
is: Q96GD0

http://identifiers.org/biomodels.db/MODEL1310110024#_9b28f6ef_8154_49f6_ae54_2dc383e17de0
name: ATP5A1
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:498
is: A8K092
boundary condition: true
initial concentration: NaN
has only substance units: false

metaM crm hs l
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
type: Species
is: CHEBI:52639
constant: false
has only substance units: false
name: N-acylsphingosine
initial concentration: 1.0
boundary condition: false

metaM acnamp c
type: Species
initial concentration: 1.0
is: CHEBI:27438
is: SBO:0000247
boundary condition: false
name: N-Acetylneuraminate 9-phosphate
is: HMDB06268
has only substance units: false
notes: FORMULA: C11H17NO12P CHARGE: -3 INCHI: InChI=1S/C11H20NO12P/c1-4(13)12-7-5(14)2-11(19,10(17)18)24-9(7)8(16)6(15)3-23-25(20,21)22/h5-9,14-16,19H,2-3H2,1H3,(H,12,13)(H,17,18)(H2,20,21,22)/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01734 EHMN_ABBREVIATION: C06241
initial amount: NaN
constant: false

metaR FCLTm
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
fast: false
modifier: MODEL1310110024#
name: Ferrochelatase, mitochondrial
is described by: ECO:0000304
reversible: false
notes: GENE_ASSOCIATION: (2235.1) or (2235.2) SUBSYSTEM: Heme synthesis EC Number: 4.99.1.1 Confidence Level: 2 AUTHORS: PMID:7983009 NOTES:NCD; r0096
is version of: http://identifiers.org/ec-code/4.99.1.1
type: Reaction
product: MODEL1310110024#
is: SBO:0000176

metaR FAOXC10DCC8DCx
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10DC-->C8DC)
type: Reaction

metaM leuktrB4 e
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
is: SBO:0000247
is: HMDB01085
initial concentration: 1.0
boundary condition: false
is: CHEBI:57461
name: leukotriene B4(1-)
has only substance units: false
constant: false
initial amount: NaN
type: Species

metaM mi14p n
has only substance units: false
is: HMDB00968
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:58282
initial amount: NaN
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
type: Species
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
constant: false

metaM ksi deg13 l
is: CHEBI:57455
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB01354
constant: false
boundary condition: false
name: keratan sulfate I, degradation product 13
initial concentration: 1.0
notes: FORMULA: C174H280N12O150S8 CHARGE: -8

metaR C8DCc
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_b1831a5e_d6d2_4fbe_8833_945e13a01255
constant: false
type: Species
initial amount: NaN
is: Q86VV3
has only substance units: false
is: SBO:0000252
name: ENTPD1
boundary condition: true
initial concentration: NaN
is encoded by: hsa:953

metaR r0603
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
is: SBO:0000176
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.12
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110024#
fast: false

metaM hcys L c
is: HMDB00742
is: SBO:0000247
name: L-homocysteine
constant: false
boundary condition: false
notes: FORMULA: C4H9NO2S CHARGE: 0 INCHI: InChI=1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00151
initial concentration: 1.0
type: Species
is: CHEBI:17588
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_433bb1b2_2e13_4334_8038_0fa81a21a37c
type: Species
initial amount: NaN
is encoded by: hsa:8310
is: SBO:0000252
initial concentration: NaN
name: ACOX3
boundary condition: true
is: O15254
constant: false
has only substance units: false

metaR PA HStn
reversible: true
name: phosphatidate transport, nuclear
is described by: ECO:0000000
kinetic law: MODEL1310110024#
product: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
reactant: MODEL1310110024#
type: Reaction

metaM pentcoa m
type: Species
boundary condition: false
name: pentanoylcoa
is: SBO:0000247
has only substance units: false
is: C00888
notes: FORMULA: C26H40N7O17P3S CHARGE: -4
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB13037

http://identifiers.org/biomodels.db/MODEL1310110024#_610f0cfc_5e7d_4bb8_aa2d_4d21e9893b60
boundary condition: true
name: CTPS1
is: SBO:0000252
initial concentration: NaN
is: P17812
is encoded by: hsa:1503
initial amount: NaN
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_3c6358ac_4e67_490d_970b_65b251c8ab7b
initial amount: NaN
name: UPP1
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is encoded by: hsa:7378

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

metaM s2l2fn2m2masn e
is: HMDB00244
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
is: C00255
notes: FORMULA: C90H145N6O65X CHARGE: -2
constant: false
initial concentration: 1.0
name: PA6
is: CHEBI:3554

metaM sbcoa c
type: Species
name: suberylcoa
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB00705
boundary condition: false
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
constant: false

metaM chito2pdol L c
name: N,N'-Diacetylchitobiosyldiphosphodolichol, human liver homolog
initial amount: NaN
is: CHEBI:12427
is: SBO:0000247
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C1240H2028N20O170P20 CHARGE: -20 INCHI: InChI=1S/C41H72N2O17P2/c1-25(2)13-9-14-26(3)15-10-16-27(4)17-11-18-28(5)19-12-20-29(6)21-22-55-61(51,52)60-62(53,54)59-41-35(43-31(8)47)38(50)39(33(24-45)57-41)58-40-34(42-30(7)46)37(49)36(48)32(23-44)56-40/h13,15,17,19,29,32-41,44-45,48-50H,9-12,14,16,18,20-24H2,1-8H3,(H,42,46)(H,43,47)(H,51,52)(H,53,54)/b26-15+,27-17+,28-19-/t29?,32-,33-,34-,35-,36-,37-,38-,39-,40+,41-/m1/s1
is: HMDB01196

metaR RE1573M
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110024#
reversible: true
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/5.3.3.8
product: MODEL1310110024#
type: Reaction
name: RE1573
is described by: ECO:0000000

metaM c6dc x
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: C14143
notes: FORMULA: C13H22NO6 CHARGE: -1
has only substance units: false
name: adipoyl carnitine
is: SBO:0000247
is: HMDB04047
type: Species

metaM pglyc hs c
constant: false
has only substance units: false
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
name: phosphatidylglycerol(1-)
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:60523

metaR r0714
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110024#
product: MODEL1310110024#
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is: SBO:0000176
reversible: false
type: Reaction
reactant: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_03002b59_298d_4c46_ab74_55bc3826f77c
constant: false
initial amount: NaN
boundary condition: true
name: MAN1C1
has only substance units: false
is: Q9NR34
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:57134

metaR r0839
name: Postulated transport reaction
type: Reaction
modifier: MODEL1310110024#
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
is described by: ECO:0000000
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.3.1.70
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
product: MODEL1310110024#
reversible: true
fast: false

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

metaR r2360
reactant: MODEL1310110024#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110024#
is: SBO:0000185
kinetic law: MODEL1310110024#
name: Organic anion transporter 5 Utilized transport
fast: false
reversible: true
type: Reaction

metaR 4NPHSFte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9344226 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Biochemical, Rat
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
reversible: true
name: xenobiotic transport
reactant: MODEL1310110024#
fast: false

metaR LINKDEG1ly
fast: false
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110024#
name: degradation of proteoglycan linkage region, lysosomal
is described by: ECO:0000000
product: MODEL1310110024#
type: Reaction

metaM 34dhmald c
type: Species
has only substance units: false
constant: false
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
name: 3,4-Dihydroxymandelaldehyde
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: C05577
is: http://identifiers.org/pubchem.compound/7903
is: HMDB06242

metaR PDE1
name: 3',5'-cyclic-nucleotide phosphodiesterase
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.35
modifier: MODEL1310110024#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.4.17
reactant: MODEL1310110024#
reversible: false
kinetic law: MODEL1310110024#
fast: false
is: SBO:0000176
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (5139.1) or (5142.1) or (5151.3) or (5153.1) or (5150.2) or (5143.1) or (5150.1) or (5137.1) or (5144.1) or (5136.2) or (5140.2) or (5151.2) or (10846.1) or (5151.5) or (5140.1) or (5141.1) or (5138.1) or (5136.1) or (5151.4) or (5151.1) or (27115.1) or (50940.1) or (8622.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10725373,PMID:10872825,PMID:10906126,PMID:10952971,PMID:11050148,PMID:11114167,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12388353,PMID:12681444,PMID:12764607,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8884271,PMID:9210593,PMID:9419816 NOTES:NCD

metaM acald e
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB00990
initial concentration: 1.0
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
is: CHEBI:15343
name: acetaldehyde
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_8d655d4c_d7ee_45b3_9089_1c279a7eb2ca
boundary condition: true
name: ST3GAL3
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6487
has only substance units: false
constant: false

metaM ump r
name: UMP
constant: false
boundary condition: false
type: Species
is: CHEBI:57865
initial amount: NaN
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
has only substance units: false
is: HMDB00288
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110024#_452a0d0d_a062_4434_a62e_8623bfcd7d2a
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:5140
initial concentration: NaN
is: A7E2E5
is: SBO:0000252
has only substance units: false
name: PDE3B
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_4f84e288_c036_4d20_b4b6_6c5eff942577
is: SBO:0000252
is encoded by: hsa:7371
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is: Q9BZX2
constant: false
name: UCK2

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

metaM gbside hs g
boundary condition: false
initial amount: NaN
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
initial concentration: 1.0
is: CHEBI:18259
name: globoside
has only substance units: false
constant: false
type: Species
is: SBO:0000247

metaR DLNLCGCPT2
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine transferase
product: MODEL1310110024#
is described by: ECO:0000000
modifier: MODEL1310110024#
is: SBO:0000176
type: Reaction
reversible: false
fast: false
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaR r2361
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110024#
reversible: true
type: Reaction
product: MODEL1310110024#
is: SBO:0000185
kinetic law: MODEL1310110024#
name: Organic anion transporter 5 Utilized transport

metaM pail hs c
is: SBO:0000247
is: CHEBI:57880
initial amount: NaN
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
boundary condition: false
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol(1-)
has only substance units: false
type: Species
constant: false

metaM so4 c
is: HMDB01448
name: sulfate
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:16189
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_53c38935_e84f_46c1_b935_b064aac5ea83
initial concentration: NaN
name: SLCO3A1
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:28232
boundary condition: true
constant: false
type: Species
is: Q9UIG8
has only substance units: false

metaR SPHMYLNtg
fast: false
is described by: ECO:0000000
product: MODEL1310110024#
type: Reaction
name: sphingomyelin intracellular transport
reversible: true
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ

metaR r0321
is: SBO:0000176
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/6.3.5.2
type: Reaction
reactant: MODEL1310110024#
modifier: MODEL1310110024#
fast: false
kinetic law: MODEL1310110024#
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:

metaM Rtotal3 e
is: HMDB00244
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: CO2FULLR3 CHARGE: -1
is: C00255
is: CHEBI:3554
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
name: R total 3 position

metaM nrvnc c
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
has only substance units: false
constant: false
is: CHEBI:32392
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB02368
type: Species
name: nervonate

metaR r2362
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110024#
fast: false
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110024#
reversible: true
product: MODEL1310110024#
type: Reaction

metaM pglyc hs e
initial amount: NaN
name: phosphatidylglycerol(1-)
has only substance units: false
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:60523
constant: false

metaR CYTK14n
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110024#
is: SBO:0000176
fast: false
name: cytidylate kinase (dCMP,CTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110024#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110024#
product: MODEL1310110024#

metaM pi x
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:43474
has only substance units: false
is: HMDB00973
type: Species
boundary condition: false
name: hydrogenphosphate
is: SBO:0000247

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

metaM acald c
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: acetaldehyde
initial amount: NaN
type: Species
is: HMDB00990
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
constant: false
is: CHEBI:15343

metaR r1579
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110024#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110024#
reversible: true
product: MODEL1310110024#
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110024#_bcd00a14_26e1_4541_9401_cef12e2e99c1
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
name: ISYNA1
is encoded by: hsa:51477
boundary condition: true
has only substance units: false
is: B3KRT1

http://identifiers.org/biomodels.db/MODEL1310110024#_ca6713f1_fe21_4a42_ae4b_da0922d29363
has part: P43034
initial concentration: NaN
type: Species
has only substance units: false
name: PAFAH1B1:PAFAH1B2:PAFAH1B3
is: SBO:0000297
boundary condition: true
is encoded by: hsa:5048
constant: false
initial amount: NaN

metaR DGULND
product: MODEL1310110024#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110024#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
reactant: MODEL1310110024#
reversible: true
name: dehydro-L-gulonate decarboxylase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_6614a817_eaba_4fb3_9e7a_ecf2a779c2a1
is: Q06830
constant: false
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: PRDX1
is encoded by: hsa:5052

metaM gln L m
is: HMDB00641
is: CHEBI:18050
is: SBO:0000247
name: L-glutamine
initial concentration: 1.0
type: Species
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false

metaR RE1520M
product: MODEL1310110024#
is: SBO:0000176
reactant: MODEL1310110024#
name: RE1520
type: Reaction
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
modifier: MODEL1310110024#
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false

metaM vacccrn c
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: Vaccenyl carnitine
has only substance units: false
is: HMDB06351
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h10-11,23H,5-9,12-22H2,1-4H3/b11-10+/t23-/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110024#_c21ad737_0738_4179_9cee_ab6d825689af
constant: false
has only substance units: false
is: SBO:0000252
type: Species
is: O43292
is encoded by: hsa:8733
initial concentration: NaN
initial amount: NaN
name: GPAA1
boundary condition: true

metaM ksi pre3 g
has only substance units: false
is: C00130
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 3
notes: FORMULA: C93H152N6O67X CHARGE: -1
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB00175
boundary condition: false
is: CHEBI:58053
constant: false

metaR AG13T7g
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
product: MODEL1310110024#
reversible: false
type: Reaction
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false

http://identifiers.org/biomodels.db/MODEL1310110024#_d790ea94_0696_4cbc_a4d0_c018f26fb3d9
has only substance units: false
type: Species
name: _F23536_1_m
constant: false
is encoded by: hsa:F23536
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR r2363
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110024#
fast: false
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
product: MODEL1310110024#

metaM hs deg21 l
name: IdoA2S-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
notes: FORMULA: C37H55NO38S2 CHARGE: -4
boundary condition: false
is: CHEBI:16126
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaR DOLPH Uer
reversible: false
is: SBO:0000176
type: Reaction
fast: false
name: Dolichol-phosphate phosphohydrolase, human (uterus)
is described by: ECO:0000000
reactant: MODEL1310110024#
product: MODEL1310110024#
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.3.51 Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110024#_07579755_5385_439e_ade7_05a149f06154
constant: false
name: DDO
is: Q99489
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8528

metaM cpppg3 c
is: HMDB01261
constant: false
initial concentration: 1.0
is: C03263
type: Species
boundary condition: false
notes: FORMULA: C36H40N4O8 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01085 EHMN_ABBREVIATION: C03263
initial amount: NaN
has only substance units: false
is: CHEBI:57309
is: SBO:0000247
name: Coproporphyrinogen III

metaR r0838
reversible: true
modifier: MODEL1310110024#
is: SBO:0000185
type: Reaction
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.1.2.4
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
name: Free diffusion
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#

metaR RE3556C
type: Reaction
is: SBO:0000176
reactant: MODEL1310110024#
name: RE3556
kinetic law: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reversible: true
is described by: ECO:0000000
product: MODEL1310110024#

metaM hspg e
initial amount: NaN
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
type: Species
constant: false
name: heparan sulfate proteoglycan
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:32366
is: HMDB02259

metaR r1578
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110024#
reversible: true

metaM so4 e
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial amount: NaN
initial concentration: 1.0
name: sulfate
has only substance units: false
is: CHEBI:16189
is: SBO:0000247
type: Species
constant: false
boundary condition: false
is: HMDB01448

metaR SPODMe
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.15.1.1
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (6649.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:12126755,PMID:3476950,PMID:9228011 NOTES:JLR
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
fast: false
reversible: false
modifier: MODEL1310110024#
name: superoxide dismutase, extracellular

metaM HC01111 c
is: SBO:0000247
constant: false
is: CHEBI:37480
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3+,4+,5-,6?/m1/s1
name: Galactose-1P

metaM dudp c
initial concentration: 1.0
initial amount: NaN
name: dUDP
is: SBO:0000247
has only substance units: false
type: Species
constant: false
is: CHEBI:60471
boundary condition: false
is: C01346
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: HMDB01000

metaR NDP7ex
is described by: ECO:0000269
fast: false
modifier: MODEL1310110024#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.6
reversible: false
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12600208 NOTES:
type: Reaction
product: MODEL1310110024#
name: nucleoside-diphosphatase (UDP), extracellular
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#

metaM ksii core2 deg7 l
is: HMDB01354
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C44H73N4O30X CHARGE: 0
name: keratan sulfate II (core 2-linked), degradation product 7
type: Species
is: CHEBI:57455
initial concentration: 1.0

metaM thexddcoa m
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: trans7,10-hexadecadienoylcoa
is: HMDB02288
notes: FORMULA: C37H58N7O17P3S CHARGE: -4
type: Species

metaR r0718
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.181
reversible: false
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reactant: MODEL1310110024#
is: SBO:0000176
fast: false
name: (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
product: MODEL1310110024#
kinetic law: MODEL1310110024#
type: Reaction
modifier: MODEL1310110024#

metaR CERT2gt
is described by: ECO:0000000
kinetic law: MODEL1310110024#
reversible: true
fast: false
is: SBO:0000185
type: Reaction
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.7.11.1
product: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
name: ceramide transport protein

metaR r0835
reversible: true
type: Reaction
product: MODEL1310110024#
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.16
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
is: SBO:0000185
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110024#_4c9b01b8_2904_411c_8135_8f249d8fff45
has only substance units: false
is encoded by: hsa:7001
boundary condition: true
name: PRDX2
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252

metaR r2364
is: SBO:0000185
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
fast: false
reactant: MODEL1310110024#
reversible: true
name: Organic anion transporter 5 Utilized transport
type: Reaction
product: MODEL1310110024#

metaR r0437
type: Reaction
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
fast: false
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/4.1.2.13
reactant: MODEL1310110024#
is described by: ECO:0000000
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
modifier: MODEL1310110024#
is: SBO:0000176
reversible: true

metaM pi r
is: CHEBI:43474
initial concentration: 1.0
is: HMDB00973
initial amount: NaN
is: C00009
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
name: hydrogenphosphate
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_5ec6abc7_c53e_4be7_9780_565582e095ba
initial amount: NaN
initial concentration: NaN
is: P07195
is: SBO:0000252
constant: false
is encoded by: hsa:3945
name: LDHB
has only substance units: false
boundary condition: true
type: Species

metaM ump n
type: Species
is: CHEBI:57865
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
has only substance units: false
is: HMDB00288
name: UMP(2-)
initial amount: NaN
constant: false

metaR ECOAH1m
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
modifier: MODEL1310110024#
fast: false
is: SBO:0000176
reversible: true
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/4.2.1.18
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
is described by: ECO:0000304

metaM focytC m
constant: false
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:16928
name: Ferrocytochrome C
has only substance units: false
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
is: SBO:0000247
initial concentration: 1.0

metaM crm hs r
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:52639
is: SBO:0000247
initial concentration: 1.0
name: N-acylsphingosine
constant: false

metaM dmnoncrn x
is: SBO:0000247
initial concentration: 1.0
type: Species
name: 4,8-dimethylnonanoyl carnitine
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C18H37NO4 CHARGE: 0
is: HMDB06202
has only substance units: false

metaR PPAm
is described by: ECO:0000269
reversible: false
name: inorganic diphosphatase
kinetic law: MODEL1310110024#
fast: false
reactant: MODEL1310110024#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.6.1.1
modifier: MODEL1310110024#

metaM hestratriol e
is: HMDB05896
boundary condition: false
initial amount: NaN
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
name: 4,17 dihydroxy estradiol

http://identifiers.org/biomodels.db/MODEL1310110024#_d21084fa_4d02_4a79_8916_6911340668c4
initial amount: NaN
boundary condition: true
is encoded by: hsa:3074
type: Species
name: HEXB
is: SBO:0000252
is: P07686
initial concentration: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_12dd8a62_79f4_4ea1_948f_9b57b6ce259c
constant: false
initial amount: NaN
has only substance units: false
type: Species
name: PDE4C
is: Q7KYS4
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5143

http://identifiers.org/biomodels.db/MODEL1310110024#_d7981c0e_650f_4a53_b7a6_285c438e4ace
name: SLC38A3
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:10991
type: Species
is: Q99624
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_9c4bf67c_eb68_4a2d_98e5_16a2908999f0
constant: false
initial amount: NaN
name: _8781_1_c
type: Species
is encoded by: hsa:8781
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110024#_ec9659cd_0be1_458f_a2e7_e286bfa10087
boundary condition: true
constant: false
name: ACOT4
type: Species
is: Q8N9L9
has only substance units: false
is: SBO:0000252
is encoded by: hsa:122970
initial concentration: NaN
initial amount: NaN

metaR r2365
product: MODEL1310110024#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110024#
fast: false
type: Reaction
reactant: MODEL1310110024#
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000

metaM nrvnc e
constant: false
is: CHEBI:32392
boundary condition: false
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB02368
name: nervonate

metaR r1841
name: Y+LAT2 Utilized transport
modifier: MODEL1310110024#
type: Reaction
product: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110024#

metaM nadp c
initial concentration: 1.0
boundary condition: false
name: Nicotinamide adenine dinucleotide phosphate
is: SBO:0000247
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: CHEBI:58349
is: HMDB00217
is: C00006

W3 CDTF: Thu Aug 30 19:37:46 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110024#_a5627f0d_a5d2_4ba1_bb66_601756e0815d
type: Species
constant: false
is: Q9H903
initial concentration: NaN
name: MTHFD2L
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:441024
has only substance units: false

metaR INSt
is: SBO:0000185
modifier: MODEL1310110024#
reactant: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:AR
kinetic law: MODEL1310110024#
name: Inosine transport (diffusion)
product: MODEL1310110024#
is described by: ECO:0000269
fast: false
reversible: true

metaM gdp c
name: GDP
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
constant: false
is: SBO:0000247
initial amount: NaN
is: C00035
initial concentration: 1.0
is: HMDB01201
is: CHEBI:58189
type: Species
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110024#_4af46032_316b_4f61_a136_b907b13cc3ee
type: Species
constant: false
initial amount: NaN
is: Q96QE2
boundary condition: true
has only substance units: false
name: SLC2A13
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:114134

metaM 3mldz c
constant: false
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
is: HMDB04181
name: 1-methylimidazole-4-acetaldehyde
initial amount: NaN
is: CHEBI:28104
notes: FORMULA: C6H8N2O CHARGE: 0 INCHI: InChI=1S/C6H8N2O/c1-8-4-6(2-3-9)7-5-8/h3-5H,2H2,1H3 EHMN_ABBREVIATION: C05827
initial concentration: 1.0

metaM dd2coa x
has only substance units: false
name: trans-Dodec-2-enoyl-CoA
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
is: CHEBI:57330
boundary condition: false
initial amount: NaN
is: HMDB03712
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221

metaM pser L c
notes: FORMULA: C3H5NO6P CHARGE: -3 INCHI: InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00621
is: CHEBI:15811
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB01721
name: O-Phospho-L-serine
boundary condition: false
constant: false

metaR r2366
product: MODEL1310110024#
is described by: ECO:0000000
reversible: true
name: Organic anion transporter 5 Utilized transport
fast: false
type: Reaction
reactant: MODEL1310110024#
is: SBO:0000185
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR MG2er
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
product: MODEL1310110024#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
fast: false

metaR LEUPHELAT2tc
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaR r0716
reactant: MODEL1310110024#
fast: false
kinetic law: MODEL1310110024#
is described by: ECO:0000000
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
product: MODEL1310110024#
is: SBO:0000176
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_0a6b42e7_cf51_4b49_aadd_fb5b5d0a4020
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
name: PAICS
is: P22234
initial concentration: NaN
is encoded by: hsa:10606
boundary condition: true
has only substance units: false

metaR FAOXC12DCTc
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of dodecanedioyl carnitine into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_47ff4ec9_7d19_4914_bfe1_75c03422c2bc
initial concentration: NaN
is: SBO:0000252
is: P37268
initial amount: NaN
name: FDFT1
constant: false
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:2222

metaM HC01412 m
boundary condition: false
is: CHEBI:61405
is: SBO:0000247
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273
has only substance units: false
name: trans-tetradec-2-enoyl-CoA(4-)
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0

metaR TMNDNCCRNt
modifier: MODEL1310110024#
is: SBO:0000185
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: transport into the mitochondria (carnitine)
reversible: false
is described by: ECO:0000000
type: Reaction
fast: false

metaM ksi deg35 l
type: Species
name: keratan sulfate I, degradation product 35
is: CHEBI:12936
boundary condition: false
notes: FORMULA: C68H113N4O54S1 CHARGE: -1
has only substance units: false
is: HMDB00143
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110024#_7c0bb220_c732_4bcb_8ea2_480c2a27bf74
is encoded by: hsa:51004
name: COQ6
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: Q9Y2Z9
initial amount: NaN
constant: false
boundary condition: true

ORG:
  orgname: University of Manchester
n:
  given: Neil
  family: Swainston

http://identifiers.org/biomodels.db/MODEL1310110024#_e0ce27ff_98a6_45f6_a915_15bd004dc8ad
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:1629
is: SBO:0000252
name: DBT
constant: false
is: P11182
has only substance units: false

metaR NOt
name: NO transport (diffusion)
is: SBO:0000185
product: MODEL1310110024#
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
reversible: true
is described by: ECO:0000000
fast: false

metaR ACNAMlt
fast: false
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
name: N-acetylneuraminate transport into lysososme
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ
modifier: MODEL1310110024#
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110024#
is described by: ECO:0000269

metaR r2367
reactant: MODEL1310110024#
is: SBO:0000185
kinetic law: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110024#_414c6784_9b03_42ca_aaaf_3d7dbc25e3d7
is encoded by: hsa:641649
type: Species
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: C9JZ62
is: SBO:0000252
name: TMEM91
has only substance units: false

metaM dcholcoa x
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
name: chenodeoxycholoyl coenzyme a
is: HMDB06292
is: CHEBI:28701
type: Species
initial amount: NaN

metaR r0834
modifier: MODEL1310110024#
product: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is version of: http://identifiers.org/ec-code/3.5.4.16
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
type: Reaction
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is: SBO:0000185
is described by: ECO:0000000

metaR 3AIBt
name: 3-amino-isobutyrate transport
reversible: false
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:HOW? IT
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110024#
is: SBO:0000185
type: Reaction
product: MODEL1310110024#

metaR HS1ly
reversible: false
is version of: http://identifiers.org/ec-code/3.10.1.1
is: SBO:0000176
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
name: heparan-N-sulfatase, lysosomal
product: MODEL1310110024#
type: Reaction
fast: false
is described by: ECO:0000000
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#

metaR ILEt5m
type: Reaction
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
name: Isoleucine mitochondrial transport
is described by: ECO:0000000
reactant: MODEL1310110024#
reversible: true
is: SBO:0000185
product: MODEL1310110024#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110024#_c297f0c7_30b5_4795_8fd4_46a79ec76c2c
type: Species
boundary condition: true
initial concentration: NaN
is: O60488
initial amount: NaN
name: ACSL4
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:2182

metaR RDH2
is described by: ECO:0000269
kinetic law: MODEL1310110024#
is: SBO:0000176
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368,PMID:9115228 NOTES:IT
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.315
product: MODEL1310110024#
name: retinol dehydrogenase (9-cis,NADH)
reactant: MODEL1310110024#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110024#_732b7841_65dd_4d05_b7f1_7f93ce88784e
boundary condition: true
initial concentration: NaN
name: PFAS
is: Q6P4B4
is encoded by: hsa:5198
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
has only substance units: false

metaR r1584
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110024#
is described by: ECO:0000000

metaM vacccrn m
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h10-11,23H,5-9,12-22H2,1-4H3/b11-10+/t23-/m0/s1
has only substance units: false
constant: false
boundary condition: false
type: Species
name: Vaccenyl carnitine
is: HMDB06351

metaM ksii core4 pre1 g
notes: FORMULA: C36H60N3O25X CHARGE: 0
type: Species
is: CHEBI:28067
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 1

metaM orot e
name: orotate
initial amount: NaN
is: HMDB00226
boundary condition: false
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
is: CHEBI:30839
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_99f8a2d1_bce5_4560_8ce1_740c9ac8525d
constant: false
is: P51857
has only substance units: false
is encoded by: hsa:6718
initial amount: NaN
name: AKR1D1
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_44d3c73f_08cb_4654_bfd8_42152874cbef
is encoded by: hsa:6723
name: SRM
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: P19623
type: Species
constant: false

metaM sucr e
initial amount: NaN
boundary condition: false
is: CHEBI:17992
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00091 EHMN_ABBREVIATION: C00089
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB00258
is: C00089
name: Sucrose
type: Species

metaR NDP7er
type: Reaction
is described by: ECO:0000000
fast: false
reversible: false
is: SBO:0000176
product: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum
kinetic law: MODEL1310110024#

metaM pro L e
name: L-proline
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:17203
is: HMDB00162
constant: false
type: Species
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_d7a8e34a_4424_46ca_b0b4_7f88de06db55
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:84532
has only substance units: false
initial concentration: NaN
name: ACSS1
initial amount: NaN
is: Q9NUB1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110024#_69061329_d36a_4f1b_8a16_0b46d26727d1
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
name: _AD000092_1_c
has only substance units: false
is encoded by: hsa:AD000092
is: SBO:0000252
type: Species

metaM hista c
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
boundary condition: false
is: HMDB00870
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:58432
type: Species
name: histamium
is: SBO:0000247
has only substance units: false

metaR RDH1
notes: GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES:IT
product: MODEL1310110024#
reactant: MODEL1310110024#
fast: false
is: SBO:0000176
name: retinol dehydrogenase (all-trans)
modifier: MODEL1310110024#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.315
is described by: ECO:0000269
kinetic law: MODEL1310110024#

metaR OCCOAtx
name: fatty acid intracellular transport
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
fast: false
product: MODEL1310110024#
reversible: true

metaR r1585
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
reactant: MODEL1310110024#
product: MODEL1310110024#
kinetic law: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110024#_2549b7d0_9056_4601_a692_11d67c9dd2b4
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: Q85KV6
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:4535
name: ND1

metaR FAOXC225m
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)m
type: Reaction

metaM o2 c
constant: false
is: C00007
has only substance units: false
initial concentration: 1.0
is: HMDB01377
type: Species
is: CHEBI:15379
name: O2
is: SBO:0000247
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_b2fbe30a_61c3_456e_9739_68a9bfd777cb
type: Species
initial concentration: NaN
is: P10619
is: SBO:0000252
is encoded by: hsa:5476
boundary condition: true
name: CTSA
constant: false
has only substance units: false
initial amount: NaN

metaM retinal cis 13 r
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
type: Species
name: 13-cis-retinal
is: SBO:0000247
is: CHEBI:45487
initial amount: NaN
boundary condition: false
is: HMDB06220
initial concentration: 1.0
constant: false
has only substance units: false

metaR GALASE12ly
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false
name: beta-galactosidase, lysosomal
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110024#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000

metaR BDMT U
type: Reaction
modifier: MODEL1310110024#
reversible: false
name: GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (uterus)
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (56052.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110024#
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.4.1.142
fast: false
kinetic law: MODEL1310110024#

metaR C4STMO2Pr
product: MODEL1310110024#
reactant: MODEL1310110024#
is: SBO:0000176
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
name: C-4 methyl sterol oxidase
modifier: MODEL1310110024#
fast: false
reversible: false
kinetic law: MODEL1310110024#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.170

metaR r0009
product: MODEL1310110024#
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.6.1.1
reversible: false
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
is: SBO:0000176
fast: false
modifier: MODEL1310110024#
type: Reaction
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
is described by: ECO:0000000

metaR S2TASE2ly
is version of: http://identifiers.org/ec-code/3.1.6.13
fast: false
modifier: MODEL1310110024#
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
product: MODEL1310110024#
name: iduronate-2-sulfatase, lysosomal

metaM ump g
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: UMP(2-)
constant: false
initial concentration: 1.0
is: HMDB00288
is: CHEBI:57865
type: Species
has only substance units: false

metaM mi14p c
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:58282
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
initial concentration: 1.0
constant: false
is: HMDB00968
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
is: SBO:0000247

metaM lnlnca e
boundary condition: false
constant: false
name: alpha-linolenate
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
is: CHEBI:32387
is: HMDB01388
type: Species

metaM orot c
has only substance units: false
name: Orotate
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB00226
type: Species
boundary condition: false
is: C00295
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
initial concentration: 1.0
is: CHEBI:30839

metaR ACNACNGALGBSIDEtg
is: SBO:0000185
fast: false
name: acnacngalgbside hs intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
product: MODEL1310110024#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_3c09e847_e9a4_4286_af3e_4066a240cf9f
is: SBO:0000252
initial amount: NaN
constant: false
name: _206_1_c
initial concentration: NaN
is encoded by: hsa:206
boundary condition: true
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_03dbcb95_fde2_4814_a831_97dc2b079385
type: Species
name: SLC19A3
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is: Q9BZV2
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:80704

metaR r0830
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.5.4.16
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reversible: true
reactant: MODEL1310110024#
is: SBO:0000185
fast: false
product: MODEL1310110024#
kinetic law: MODEL1310110024#
is described by: ECO:0000000

metaM pro L c
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
initial concentration: 1.0
has only substance units: false
is: CHEBI:17203
boundary condition: false
name: L-proline
is: HMDB00162
type: Species
constant: false
initial amount: NaN
is: SBO:0000247

metaM dopa c
has only substance units: false
is: SBO:0000247
is: HMDB00073
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
constant: false
is: CHEBI:59905
name: dopaminium(1+)
type: Species
initial amount: NaN

metaM dcholcoa c
is: HMDB06292
name: chenodeoxycholoyl coenzyme a
type: Species
has only substance units: false
is: CHEBI:28701
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false

metaM xylt c
name: xylitol
has only substance units: false
is: HMDB02917
boundary condition: false
is: CHEBI:17151
initial concentration: 1.0
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
is: SBO:0000247
constant: false
type: Species
initial amount: NaN

metaR RETNt
type: Reaction
product: MODEL1310110024#
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
name: retinoic acid transport

metaM citr L m
constant: false
is: SBO:0000247
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
initial amount: NaN
is: HMDB00904
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
name: L-citrulline
is: CHEBI:16349

metaR r1583
type: Reaction
fast: false
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_10bceffc_645d_4b6a_91a9_97171b406e33
constant: false
boundary condition: true
initial amount: NaN
is: Q8N4Q0
initial concentration: NaN
is encoded by: hsa:284273
has only substance units: false
is: SBO:0000252
name: ZADH2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_0365fdd6_eed1_4a06_b252_aceb56306f47
is: SBO:0000252
initial amount: NaN
is: P50747
type: Species
constant: false
name: HLCS
is encoded by: hsa:3141
has only substance units: false
initial concentration: NaN
boundary condition: true

metaM hestratriol c
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB05896
boundary condition: false
type: Species
initial amount: NaN
name: 4,17 dihydroxy estradiol
has only substance units: false
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1

metaR CRNtim
reactant: MODEL1310110024#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
reversible: false
product: MODEL1310110024#
fast: false
modifier: MODEL1310110024#
name: L-carnitine transport out of mitochondria via diffusion
is described by: ECO:0000269
kinetic law: MODEL1310110024#

metaR RE1342C
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
is: SBO:0000176
product: MODEL1310110024#
reactant: MODEL1310110024#
type: Reaction
kinetic law: MODEL1310110024#
name: RE1342
fast: false

metaR CYOR u10m
name: ubiquinol-6 cytochrome c reductase, Complex III
fast: false
is: SBO:0000185
is described by: ECO:0000134
type: Reaction
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
reactant: MODEL1310110024#
reversible: false
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.5.1.92
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110024#

metaR FAOXC227C226m
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:7-->C22:6)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_87c204ba_d00c_4c8b_a981_e80c2022d101
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:10400
boundary condition: true
is: SBO:0000252
name: PEMT
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_8e78f7e8_257a_4381_906e_c32ab43a0fb9
is: Q6LEN6
name: CHAT
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1103
constant: false
is: SBO:0000252
boundary condition: true
type: Species

metaR GLNASNNaEx
name: L-glutamine/L-asparagine Na-dependent exchange (Gln-L in)
reversible: false
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
type: Reaction
modifier: MODEL1310110024#
is described by: ECO:0000269
product: MODEL1310110024#
fast: false
reactant: MODEL1310110024#

metaR IPDDIx
fast: false
is described by: ECO:0000134
name: isopentenyl-diphosphate D-isomerase
type: Reaction
notes: GENE_ASSOCIATION: (3422.1) or (91734.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
product: MODEL1310110024#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.3.2
reversible: true
reactant: MODEL1310110024#

metaR EX c10dc
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for sebacoyl carnitine
type: Reaction

metaR DNDPt17m
product: MODEL1310110024#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
modifier: MODEL1310110024#
type: Reaction
reactant: MODEL1310110024#
reversible: false
name: dUDP transport via dCDP antiport
kinetic law: MODEL1310110024#

metaM ksi pre23 g
name: keratan sulfate I biosynthesis, precursor 23
initial amount: NaN
is: CHEBI:28067
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C185H296N13O153S7X CHARGE: -8
type: Species
initial concentration: 1.0

metaR SO4tl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
name: Sulfate transport (lysosome)
fast: false
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110024#

metaR r1588
kinetic law: MODEL1310110024#
product: MODEL1310110024#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110024#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110024#_9b056814_4861_41e2_bd88_4f82c5afc101
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
is: P21439
name: ABCB4
is encoded by: hsa:5244

metaM ump e
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: UMP(2-)
is: CHEBI:57865
is: HMDB00288
type: Species

metaM 3mob e
has only substance units: false
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
boundary condition: false
initial concentration: 1.0
type: Species
name: 3-methyl-2-oxobutanoate
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:11851
is: HMDB00019

metaM ksi deg7 l
initial amount: NaN
name: keratan sulfate I, degradation product 7
constant: false
initial concentration: 1.0
is: CHEBI:57455
boundary condition: false
notes: FORMULA: C210H337N15O181S10 CHARGE: -10
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB01354

metaM lnlnca c
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
name: alpha-linolenate
has only substance units: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
initial amount: NaN
is: CHEBI:32387
boundary condition: false
is: HMDB01388

http://identifiers.org/biomodels.db/MODEL1310110024#_157e01a8_7c34_43a6_96ca_2ccc5650db5c
boundary condition: true
is encoded by: hsa:84693
constant: false
name: MCEE
type: Species
has only substance units: false
is: Q96PE7
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaM dopa e
type: Species
boundary condition: false
is: HMDB00073
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
initial concentration: 1.0
name: dopaminium(1+)
is: SBO:0000247
is: CHEBI:59905
constant: false
has only substance units: false
initial amount: NaN

metaR DOPASULT
reversible: false
fast: false
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/2005)
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.2.1
name: Dopamine Sulfotransferase
product: MODEL1310110024#
modifier: MODEL1310110024#
is described by: ECO:0000269
is: SBO:0000176

metaM dtdp e
constant: false
is: CHEBI:58369
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB01274
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363

metaM hx2coa x
is: HMDB13037
type: Species
has only substance units: false
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: trans-Hex-2-enoyl-CoA
initial amount: NaN
is: C00888
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_e8dfc131_ab0c_4377_9b44_34d361dbcac0
is encoded by: hsa:22305
boundary condition: true
initial concentration: NaN
name: _22305_1_c
type: Species
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN

metaM strdnccoa m
has only substance units: false
name: stearidonyl coenzyme A
is: http://identifiers.org/pubchem.compound/47205473
boundary condition: false
is: SBO:0000247
is: C16163
constant: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
is: HMDB06519
initial concentration: 1.0
type: Species
initial amount: NaN

metaR 2HCO3 NAt
kinetic law: MODEL1310110024#
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (57835.3) or (8671.1) or (57835.2) or (57835.1) or (57835.4) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
name: bicarbonate transport (Na/HCO3 1:2 cotransport)
fast: false
reactant: MODEL1310110024#
reversible: true
type: Reaction
modifier: MODEL1310110024#

metaR ACNACNGALGBSIDEte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
type: Reaction
reversible: true
kinetic law: MODEL1310110024#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110024#
fast: false
name: acnacngalgbside hs transport
reactant: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_d98f66f8_3752_4c35_8fce_a4e0f7da8591
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
type: Species
is: P32119
initial amount: NaN
is encoded by: hsa:7001
name: PRDX2
boundary condition: true

metaM 34dhoxmand m
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
boundary condition: false
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
is: CHEBI:27637
is: HMDB01866
name: 3,4-Dihydroxymandelate

http://identifiers.org/biomodels.db/MODEL1310110024#_b1e914f2_f6e5_4dad_9e39_79f16ad9f6a5
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: HMGCS1
constant: false
is: Q01581
is: SBO:0000252
is encoded by: hsa:3157
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110024#_d7c21d25_d477_4a2a_8953_9d0c0c270377
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000297
type: Species
has only substance units: false
has part: Q13733
constant: false
is encoded by: hsa:480
name: ATP1A4:ATP1B1

metaR ORNtiDF
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110024#
type: Reaction
product: MODEL1310110024#
is: SBO:0000185
modifier: MODEL1310110024#
reactant: MODEL1310110024#
name: ornithine transport via diffusion (extracellular to cytosol)
notes: GENE_ASSOCIATION: (6542.1) or (6541.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
fast: false

metaR BTNt2
type: Reaction
product: MODEL1310110024#
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD
kinetic law: MODEL1310110024#
is described by: ECO:0000269
modifier: MODEL1310110024#
name: Biotin reversible transport via proton symport

metaM arachcrn m
is: SBO:0000247
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
type: Species
is: HMDB06460
name: arachidyl carnitine
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_ebd866d0_5e5e_48c5_a427_d89ba55ec907
is encoded by: hsa:5172
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
is: O43511
initial concentration: NaN
name: SLC26A4
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_142f1ddd_23ae_4ee2_a28d_e7816c4b348b
initial amount: NaN
is: P50440
constant: false
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:2628
name: GATM
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110024#_7d62b1df_abe1_46f7_b8fc_a11447cfd45e
has only substance units: false
is: SBO:0000252
is: Q9H3S5
is encoded by: hsa:93183
initial concentration: NaN
boundary condition: true
constant: false
name: PIGM
type: Species
initial amount: NaN

metaM CE4876 r
is: CHEBI:57923
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876
boundary condition: false
name: delta12-Prostaglandin J2
initial concentration: 1.0
constant: false

metaR r1589
reversible: true
kinetic law: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
reactant: MODEL1310110024#
product: MODEL1310110024#
is described by: ECO:0000000

metaM dlnlcgcrn m
initial amount: NaN
is: SBO:0000247
is: CHEBI:16004
has only substance units: false
name: dihomo-gamma-linolenyl carnitine
constant: false
notes: FORMULA: C27H47NO4 CHARGE: 0 INCHI: InChI=1/C27H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,25H,5-8,11,14,17-24H2,1-4H3
is: HMDB01311
type: Species
initial concentration: 1.0
boundary condition: false

metaM dec24dicoa m
has only substance units: false
is: HMDB01168
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
name: 2,4-decadienoylcoa
notes: FORMULA: C31H46N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110024#_945af771_92d5_4c33_8792_8a4f43c4c31b
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:197257
name: LDHD

http://identifiers.org/biomodels.db/MODEL1310110024#_70816cfe_d0f9_44e4_9961_b6bdeb79f296
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:57835
initial amount: NaN
type: Species
name: SLC4A5
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_8e544c33_a273_49ef_ad1d_247faa4f14e6
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:131
is: P40394
name: ADH7
constant: false
boundary condition: true

metaR UAGDP
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.7.7.23
kinetic law: MODEL1310110024#
fast: false
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
modifier: MODEL1310110024#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
name: UDP-N-acetylglucosamine diphosphorylase
reversible: false

metaM 3mob c
is: HMDB00019
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
name: 3-methyl-2-oxobutanoate
type: Species
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
is: CHEBI:11851

http://identifiers.org/biomodels.db/MODEL1310110024#_946b9a9f_6a9a_4b73_afd4_f90cd8968c71
name: XYLB
initial amount: NaN
has only substance units: false
is encoded by: hsa:9942
initial concentration: NaN
is: O75191
boundary condition: true
type: Species
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110024#_57957004_4f00_420e_a3fd_032e657a0fd6
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
name: PIGP
is encoded by: hsa:51227
initial concentration: NaN

metaM ump c
has only substance units: false
is: C00105
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:57865
is: SBO:0000247
type: Species
is: HMDB00288
name: UMP

metaR r1586
is described by: ECO:0000000
product: MODEL1310110024#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#

metaM nmn c
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB00229
initial amount: NaN
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
is: C00455
constant: false
type: Species
name: NMN
is: CHEBI:14649

metaM dtdp c
boundary condition: false
name: dTDP
type: Species
initial concentration: 1.0
is: SBO:0000247
is: C00363
is: HMDB01274
initial amount: NaN
has only substance units: false
is: CHEBI:58369
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_1287ebb6_baac_49fc_a17a_5cec2505139d
initial amount: NaN
boundary condition: true
is: F8VQS7
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:55967
constant: false
name: NDUFA12
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_7928005b_2949_49d4_ad62_d9b23d53655a
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:83530
name: _83530_1_c
initial concentration: NaN
is: SBO:0000252

metaR STCOAtx
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110024#
is described by: ECO:0000000
reactant: MODEL1310110024#
product: MODEL1310110024#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
name: fatty acid intracellular transport

metaR AHEXASE2ly
kinetic law: MODEL1310110024#
type: Reaction
reversible: false
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
modifier: MODEL1310110024#
reactant: MODEL1310110024#
product: MODEL1310110024#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal

metaM hista e
is: SBO:0000247
is: CHEBI:58432
has only substance units: false
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
initial concentration: 1.0
is: HMDB00870
type: Species
constant: false
name: histamium
initial amount: NaN
boundary condition: false

metaR r0330
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500,PMID:8615641 NOTES:
modifier: MODEL1310110024#
is described by: ECO:0000000
kinetic law: MODEL1310110024#
fast: false
is: SBO:0000176
reactant: MODEL1310110024#
reversible: false
product: MODEL1310110024#
type: Reaction
name: 5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1

http://identifiers.org/biomodels.db/MODEL1310110024#_67c066b1_8612_42b1_aaab_542d8931a291
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:56474
boundary condition: true
is: Q9NRF8
constant: false
is: SBO:0000252
name: CTPS2
type: Species

metaR NADPHtru
reactant: MODEL1310110024#
is described by: ECO:0000000
is: SBO:0000185
fast: false
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
reversible: false
name: NADPH transporter, endoplasmic reticulum
type: Reaction
product: MODEL1310110024#

metaR DMATTx
fast: false
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
is: SBO:0000176
reversible: false
product: MODEL1310110024#
modifier: MODEL1310110024#
name: dimethylallyltranstransferase
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.5.1.1
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_c6c64d53_c770_4742_a813_f548f4a1b757
is: SBO:0000252
initial concentration: NaN
is: Q6ZWP6
boundary condition: true
type: Species
has only substance units: false
name: ACAD8
constant: false
initial amount: NaN
is encoded by: hsa:27034

metaM o2 e
is: C00007
type: Species
boundary condition: false
is: HMDB01377
is: CHEBI:15379
has only substance units: false
name: O2
initial concentration: 1.0
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: SBO:0000247
initial amount: NaN
constant: false

metaR DOPAtu
name: Dopamine uniport
is described by: ECO:0000269
modifier: MODEL1310110024#
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110024#
reversible: true
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#

metaR r1587
product: MODEL1310110024#
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110024#_db1a22e2_4ac3_4404_b534_f1d238258db1
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
is: F8W1L5
name: GPD1
is encoded by: hsa:2819
initial amount: NaN
constant: false
initial concentration: NaN

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

metaM pail hs n
has only substance units: false
is: CHEBI:57880
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
initial concentration: 1.0
is: SBO:0000247
type: Species
name: 1-phosphatidyl-1D-myo-inositol(1-)
constant: false
initial amount: NaN
boundary condition: false

metaM citr L c
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
initial concentration: 1.0
is: CHEBI:16349
constant: false
initial amount: NaN
has only substance units: false
name: L-citrulline
is: HMDB00904

metaR ADA
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:Added EC- JLR
type: Reaction
kinetic law: MODEL1310110024#
product: MODEL1310110024#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.4.4
is: SBO:0000176
name: Adenosine deaminase
reactant: MODEL1310110024#
reversible: false

metaR HDD2COAtx
kinetic law: MODEL1310110024#
name: hdd2coa intracellular transport
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
reactant: MODEL1310110024#
is: SBO:0000185
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000

metaR ACCOAgt
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12739170 NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ
reversible: true
reactant: MODEL1310110024#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110024#
is: SBO:0000185
fast: false
product: MODEL1310110024#
name: acetyl-coa transport

http://identifiers.org/biomodels.db/MODEL1310110024#_d12f359c_01c0_4f4e_98a7_18299d1a2a86
is: E7ET32
is encoded by: hsa:2592
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
name: GALT

metaM pro L m
initial amount: NaN
boundary condition: false
is: CHEBI:17203
is: SBO:0000247
is: HMDB00162
type: Species
has only substance units: false
constant: false
name: L-proline
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110024#_bd71c510_7434_477d_b680_2a97bfce24c1
is encoded by: hsa:501
is: E7EPT3
is: SBO:0000252
constant: false
name: ALDH7A1
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_81d7f1e7_e12f_4dd3_9420_5843783c6998
initial concentration: NaN
type: Species
is encoded by: hsa:3038
name: HAS3
is: SBO:0000252
is: Q96RV2
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN

metaM asp L c
is: CHEBI:29991
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: L-aspartate(1-)
is: SBO:0000247
initial amount: NaN
is: HMDB00191
type: Species
constant: false

metaR LALDO
is version of: http://identifiers.org/ec-code/1.1.1.1
type: Reaction
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: NOTES:EC 1.2.1.1 NCD
fast: false
product: MODEL1310110024#
modifier: MODEL1310110024#
reversible: true
is described by: ECO:0000000
name: D-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
kinetic law: MODEL1310110024#
is: SBO:0000176
reactant: MODEL1310110024#

metaR r0984
is described by: ECO:0000000
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110024#
name: solute carrier family 27 (fatty acid transporter), member 5 TCDB:4.C.1.1.5 TCDB:4.C.1.1.8
product: MODEL1310110024#
fast: false

metaR GRTTx
is: SBO:0000176
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
product: MODEL1310110024#
name: geranyltranstransferase
is described by: ECO:0000134
reversible: false
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.5.1.1
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110024#_773c51be_a03d_42a1_9f93_c48c85c8efe7
is encoded by: hsa:4121
constant: false
type: Species
is: P33908
boundary condition: true
has only substance units: false
name: MAN1A1
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_0e47821f_f626_4da8_8b36_d1d69619457a
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:8897
initial concentration: NaN
is: Q13615
name: MTMR3
boundary condition: true
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_883a1f0a_0e5e_400c_9e38_44d106966edb
is: P11926
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
name: ODC1
is encoded by: hsa:4953
type: Species
boundary condition: true

metaM r5p r
initial amount: NaN
is: HMDB00618
is: SBO:0000247
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-3-2(1-12-14(9,10)11)13-5(8)4(3)7/h2-8H,1H2,(H2,9,10,11)/t2-,3-,4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
has only substance units: false
is: CHEBI:18189
name: alpha-D-Ribose 5-phosphate
constant: false
initial concentration: 1.0
type: Species
boundary condition: false

metaM udpg c
is: C00029
boundary condition: false
is: HMDB00286
type: Species
has only substance units: false
is: SBO:0000247
name: UDPglucose
constant: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
initial concentration: 1.0
is: CHEBI:58367
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_3e540d94_cb55_4fd8_b0c9_8298fff3921f
initial amount: NaN
has only substance units: false
is encoded by: hsa:125206
boundary condition: true
type: Species
initial concentration: NaN
constant: false
name: SLC5A10
is: A0PJK1
is: SBO:0000252

metaR S6T18g
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/2.8.2.17
reversible: false
modifier: MODEL1310110024#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110024#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.8.2.21

http://identifiers.org/biomodels.db/MODEL1310110024#_898bbbf2_81a4_4593_873c_4f1405d45595
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:4967
is: SBO:0000252
is: B4E3E9
initial concentration: NaN
type: Species
name: OGDH
constant: false

metaR EX CE1943 LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: spermidine dialdehyde exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_b1662538_d939_4762_b271_094d8a6f48f8
has only substance units: false
name: NDUFA7
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:4701
type: Species
is: Q6FG42
initial amount: NaN
is: SBO:0000252

metaM prpncoa m
initial amount: NaN
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
constant: false
is: SBO:0000247
is: CHEBI:57367
type: Species
is: HMDB02307
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: acryloyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110024#_0ff018cf_be54_42ee_ba1f_e5efefb3a31a
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
is: O00217
name: NDUFS8
initial concentration: NaN
is encoded by: hsa:4728

metaM gdp m
is: C00035
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
has only substance units: false
boundary condition: false
name: GDP
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01201
is: CHEBI:58189
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_71f09992_7285_4d09_8fd4_7bc3b0ec69ec
constant: false
type: Species
is: SBO:0000252
name: NADSYN1
has only substance units: false
initial amount: NaN
is encoded by: hsa:55191
is: Q6IA69
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110024#_0ca7dd7c_b0f2_42a2_ab2d_a3c65fdb10f2
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:6821
is: P51687
name: SUOX
has only substance units: false
type: Species

metaM strdnccoa c
is: SBO:0000247
name: stearidonyl coenzyme A
initial amount: NaN
has only substance units: false
type: Species
is: http://identifiers.org/pubchem.compound/47205473
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
initial concentration: 1.0
is: HMDB06519
boundary condition: false
is: C16163
constant: false

metaR RE3004M
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE3004
is: SBO:0000176
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110024#_0b7c77b5_bd92_457f_9236_d7fe80f3d6f9
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:84264
is: Q6PII5
initial concentration: NaN
boundary condition: true
constant: false
name: HAGHL

metaM dc2coa x
is: HMDB01168
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
name: trans-Dec-2-enoyl-CoA
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
constant: false

metaR HSD3A2r
reversible: true
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
is version of: http://identifiers.org/ec-code/1.1.1.225
reactant: MODEL1310110024#
product: MODEL1310110024#
is described by: ECO:0000000
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
fast: false

metaR r0983
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
product: MODEL1310110024#
name: solute carrier family 27 (fatty acid transporter), member 5 TCDB:4.C.1.1.5 TCDB:4.C.1.1.8
type: Reaction
reactant: MODEL1310110024#
fast: false
reversible: false
kinetic law: MODEL1310110024#

metaR FAOXC225x
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_1b9f6393_58fe_45f7_9752_ac65d7bed1c4
boundary condition: true
is encoded by: hsa:1962
is: SBO:0000252
type: Species
initial amount: NaN
is: Q9NY65
name: EHHADH
initial concentration: NaN
constant: false
has only substance units: false

metaM dmnoncrn m
has only substance units: false
name: 4,8 dimethylnonanoyl carnitine
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C18H37NO4 CHARGE: 0 INCHI: InChI=1/C18H35NO4/c1-14(2)8-7-9-15(3)10-11-18(22)23-16(12-17(20)21)13-19(4,5)6/h14-16H,7-13H2,1-6H3
constant: false
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB06202

http://identifiers.org/biomodels.db/MODEL1310110024#_4c3f91f4_aaa1_4119_8ebd_d2978d343254
type: Species
is encoded by: hsa:130
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: P28332
name: ADH6
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110024#_5ec1f934_da62_4149_924e_e2213e5b188a
is: O43181
constant: false
type: Species
initial amount: NaN
boundary condition: true
name: NDUFS4
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4724

metaM vacc e
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:30828
type: Species
name: trans-vaccenate

metaM gdp n
type: Species
boundary condition: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: HMDB01201
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58189
name: GDP(3-)
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_bac3d578_d50d_4a6e_904f_4d21d634698f
name: GMPR2
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
is: Q9P2T1
initial amount: NaN
type: Species
is encoded by: hsa:51292

metaM core4 g
notes: FORMULA: C24H40N3O15X CHARGE: 0
initial concentration: 1.0
boundary condition: false
is: CHEBI:16478
initial amount: NaN
has only substance units: false
name: Core 4
is: SBO:0000247
type: Species
constant: false

metaM citr L e
name: citr_L[e]
constant: false
boundary condition: false
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
initial amount: NaN
is: CHEBI:16349
is: HMDB00904
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species

metaM ptrc e
initial amount: NaN
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
name: Putrescine
constant: false
has only substance units: false
is: C00134
initial concentration: 1.0
is: HMDB01414
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:326268

metaM ksii core2 deg8 l
is: CHEBI:12936
initial amount: NaN
name: keratan sulfate II (core 2-linked), degradation product 8
notes: FORMULA: C36H60N3O25X CHARGE: 0
has only substance units: false
is: HMDB00143
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110024#_7597b484_7f3d_4028_ae02_8fcb214fb6ef
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10166
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
name: SLC25A15
is: Q9Y619

metaR GLCter
type: Reaction
reactant: MODEL1310110024#
name: glucose transport, endoplasmic reticulum
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD
is described by: ECO:0000000
reversible: true
product: MODEL1310110024#
kinetic law: MODEL1310110024#

metaR C204CPT2
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
product: MODEL1310110024#
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TDV C20:4 transport
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false
name: arachidonic acid transport into the mitochondria
reversible: false

metaR LSTO1r
type: Reaction
reactant: MODEL1310110024#
reversible: false
product: MODEL1310110024#
modifier: MODEL1310110024#
fast: false
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
name: Lathosterol oxidase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.21.6
is: SBO:0000176

metaM fadh2 c
is: SBO:0000247
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
initial amount: NaN
type: Species
name: FADH2(2-)
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:58307
boundary condition: false
is: HMDB01197

metaM ksi deg38 l
constant: false
initial concentration: 1.0
is: HMDB00143
initial amount: NaN
type: Species
name: keratan sulfate I, degradation product 38
is: CHEBI:12936
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C54H91N3O41 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110024#_570cafdf_8767_4715_ad4a_ca319086220e
has part: Q6IB54
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:522
type: Species
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
constant: false
is: SBO:0000297
boundary condition: true

metaR IMPC
fast: false
is version of: http://identifiers.org/ec-code/2.1.2.3
reversible: true
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 3.5.4.10 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
product: MODEL1310110024#
modifier: MODEL1310110024#
type: Reaction
kinetic law: MODEL1310110024#
is: SBO:0000176
is described by: ECO:0000269
name: IMP cyclohydrolase

metaM dgdp c
boundary condition: false
is: SBO:0000247
is: CHEBI:58595
initial concentration: 1.0
name: dGDP
initial amount: NaN
is: HMDB00960
is: C00361
constant: false
has only substance units: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
type: Species

metaM xylt e
name: xylitol
is: HMDB02917
type: Species
is: CHEBI:17151
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaR BIOCYTtn
name: biocytin transport, nuclear
reversible: true
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:16011464,PMID:5867120,PMID:7758201,PMID:8593541 NOTES:IT
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110024#
is described by: ECO:0000000
kinetic law: MODEL1310110024#

metaR r1106
name: Postulated transport reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000000
kinetic law: MODEL1310110024#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110024#_9d813215_0ebe_449e_a6f4_d33d2c19157a
name: SLC23A2
constant: false
type: Species
is: Q9UGH3
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:9962
initial amount: NaN
boundary condition: true

metaR BAAT2x
reversible: false
fast: false
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.3.1.65
modifier: MODEL1310110024#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110024#
name: bile acid Coenzyme A: amino acid N-acyltransferase
is described by: ECO:0000269
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ

metaR r1580
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110024#
reversible: true
product: MODEL1310110024#
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110024#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM HC01223 m
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
is: CHEBI:57340
type: Species
initial amount: NaN
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false

metaM itaccoa m
is: CHEBI:57381
is: HMDB03377
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
name: itaconyl-CoA(5-)

http://identifiers.org/biomodels.db/MODEL1310110024#_d4116c9a_25f1_4d9c_a12f_d6cefecd1d46
boundary condition: true
is encoded by: hsa:10423
name: CDIPT
constant: false
initial concentration: NaN
is: O14735
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110024#_07147052_8927_48ba_bbfc_5029892179e6
initial concentration: NaN
is: P35558
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
name: PCK1
is encoded by: hsa:5105
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_0fc3af93_7771_4bcd_9d65_e35e3736c8b2
name: ST8SIA1
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:6489
type: Species
initial concentration: NaN
is: Q92185
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_52f99975_266f_46f3_a8ba_762770c36dee
is: SBO:0000252
initial concentration: NaN
is: O75964
name: ATP5L
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:10632
type: Species

metaM 3mob m
is: CHEBI:11851
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
is: HMDB00019
constant: false
name: 3-methyl-2-oxobutanoate

metaR CSPG Etly
type: Reaction
reversible: false
name: chondroitin sulfate E transport, extracellular to lysosome
reactant: MODEL1310110024#
product: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110024#

metaM CE5798 e
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: neuromedin N (1-4)
is: CHEBI:27485
notes: FORMULA: C26H40N4O6 CHARGE: 0 INCHI: InChI=1/C26H40N4O6/c1-5-15(3)21(27)25(34)30-13-7-8-20(30)24(33)28-19(14-17-9-11-18(31)12-10-17)23(32)29-22(26(35)36)16(4)6-2/h9-12,15-16,19-22,31H,5-8,13-14,27H2,1-4H3,(H,28,33)(H,29,32)(H,35,36)/t15-,16-,19+,20-,21-,22-/m1/s1 EHMN_ABBREVIATION: CE5798
constant: false
type: Species
is: HMDB02710
initial concentration: 1.0
boundary condition: false

metaM 3hexdtricoa m
name: 3,7,10-hexadecatrienoylcoa
boundary condition: false
has only substance units: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
initial amount: NaN
is: HMDB02288
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247

metaM o2s e
constant: false
type: Species
is: CHEBI:18421
has only substance units: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
initial concentration: 1.0
boundary condition: false
name: superoxide
is: HMDB02168
initial amount: NaN
is: SBO:0000247

metaM em2emgacpail hs r
initial amount: NaN
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:16038
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol (H7)
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species

metaR NADHtpu
product: MODEL1310110024#
reactant: MODEL1310110024#
reversible: false
type: Reaction
name: NADH transporter, peroxisome
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
kinetic law: MODEL1310110024#
is described by: ECO:0000000

metaR S6T7g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110024#
reversible: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110024#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_1b059467_1b75_446f_8bda_1ca3d0414860
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
is: A5PKZ1
name: GALNT5
is encoded by: hsa:11227
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_1d77089d_6b51_4627_8843_b85784d3b641
is: P48448
constant: false
is encoded by: hsa:222
initial amount: NaN
name: ALDH3B2
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false

metaM ptrc c
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: Putrescine
type: Species
is: HMDB01414
is: C00134
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
is: CHEBI:326268
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_149605c5_68f3_474f_b896_11e3855004fe
is: Q7KZA3
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:2235
name: FECH
type: Species
is: SBO:0000252
boundary condition: true

metaM hom L e
initial concentration: 1.0
boundary condition: false
is: HMDB00719
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
constant: false
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:15699
name: L-homoserine

metaR ACACT5p
product: MODEL1310110024#
name: acetyl-CoA C-acyltransferase (decanoyl-CoA), peroxisomal
type: Reaction
kinetic law: MODEL1310110024#
reversible: false
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
reactant: MODEL1310110024#

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_d80eefba_4402_4d3a_b1f6_931f3353ec4f
boundary condition: true
is encoded by: hsa:H17063
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
constant: false
name: _H17063_1_m
is: SBO:0000252

metaM c6dc c
is: HMDB00705
type: Species
notes: FORMULA: C13H22NO6 CHARGE: -1
has only substance units: false
name: adipoyl carnitine
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaR APOCFm
is described by: ECO:0000000
kinetic law: MODEL1310110024#
is: SBO:0000176
reversible: false
type: Reaction
name: Apocarboxylase formation, mitochondrial
reactant: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:IT faked reaction to balance reaction in human biotin metabolism
product: MODEL1310110024#

metaM rib D c
is: HMDB00283
name: D-ribose
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
initial concentration: 1.0
type: Species
is: CHEBI:16988
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110024#_72b788b2_2a5e_4505_a0a7_e887594270be
is encoded by: hsa:115286
name: SLC25A26
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true

metaR r1581
fast: false
kinetic law: MODEL1310110024#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110024#
reactant: MODEL1310110024#
type: Reaction

metaM octdececoa m
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
name: octadecenoylcoa
is: SBO:0000247
type: Species
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5280355

metaM dec24dicoa x
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB01168
name: 2,4-decadienoylcoa
initial amount: NaN
constant: false
boundary condition: false

metaR PTDCAt
name: fatty acid transport via diffusion
kinetic law: MODEL1310110024#
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: true
reactant: MODEL1310110024#
type: Reaction

metaM cs a deg1 l
initial amount: NaN
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 1
is: CHEBI:57455
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
is: SBO:0000247
boundary condition: false
is: HMDB01354
type: Species
constant: false
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110024#_95c708bf_2cf4_4735_972e_75494bdb7260
type: Species
name: NDUFB8
boundary condition: true
has only substance units: false
is encoded by: hsa:4714
is: O95169
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252

metaM m1mpdol L c
is: SBO:0000247
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human liver homolog
notes: FORMULA: C1360H2228N20O270P20 CHARGE: -20 INCHI: InChI=1S/C53H92N2O27P2/c1-27(2)13-9-14-28(3)15-10-16-29(4)17-11-18-30(5)19-12-20-31(6)21-22-73-83(69,70)82-84(71,72)81-51-39(55-33(8)61)43(65)47(37(26-59)77-51)78-50-38(54-32(7)60)42(64)48(36(25-58)76-50)79-53-46(68)49(41(63)35(24-57)75-53)80-52-45(67)44(66)40(62)34(23-56)74-52/h13,15,17,19,31,34-53,56-59,62-68H,9-12,14,16,18,20-26H2,1-8H3,(H,54,60)(H,55,61)(H,69,70)(H,71,72)/b28-15+,29-17+,30-19+/t31?,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47-,48-,49+,50+,51-,52-,53+/m1/s1
is: CHEBI:28067
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false

metaR DM Ser Gly Ala X Gly ly
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser-Gly/Ala-X-Gly(ly)
type: Reaction

metaR S6TASE16ly
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
product: MODEL1310110024#
name: N-acetylglucosamine-6-sulfatase, lysosomal
reactant: MODEL1310110024#
is described by: ECO:0000000
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.14
modifier: MODEL1310110024#
is: SBO:0000176
kinetic law: MODEL1310110024#
fast: false

metaM HC02023 r
initial amount: NaN
notes: FORMULA: C45H78O2 CHARGE: 0 INCHI: InChI=1S/C45H78O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h14-15,26,35-36,38-42H,7-13,16-25,27-34H2,1-6H3/b15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1
constant: false
initial concentration: 1.0
name: Cholesterol-ester-ol
has only substance units: false
type: Species
is: CHEBI:46898
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110024#_80e4ff6e_c55e_4aaa_a7a4_ae3aed70f099
has only substance units: false
is encoded by: hsa:2937
constant: false
initial concentration: NaN
initial amount: NaN
name: GSS
is: SBO:0000252
type: Species
boundary condition: true
is: P48637

metaM o2s c
is: HMDB02168
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:18421
initial concentration: 1.0
name: superoxide

metaR GUAPRT
product: MODEL1310110024#
type: Reaction
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
name: guanine phosphoribosyltransferase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.8
reactant: MODEL1310110024#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine and 6-mercaptopurine can replace hypoxanthine EC added (2.4.2.7 makes the same reaction) IT
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110024#_2e2abe12_9106_4832_b7c6_2b50002bd990
is encoded by: hsa:10559
name: SLC35A1
constant: false
has only substance units: false
initial concentration: NaN
is: P78382
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN

metaM asp L e
constant: false
is: CHEBI:29991
is: SBO:0000247
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: L-aspartate(1-)
is: HMDB00191
type: Species
has only substance units: false

metaM crm hs c
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
name: N-acylsphingosine
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
is: CHEBI:52639

http://identifiers.org/biomodels.db/MODEL1310110024#_91ccdb13_2175_4a63_a09c_87510285c0fc
has part: Q8NBL9
is encoded by: hsa:51604
is encoded by: hsa:10026
type: Species
name: PIGK:PIGU:PIGT:GPAA1:PIGS
initial amount: NaN
boundary condition: true
has part: Q92643
is encoded by: hsa:8733
has part: O43292
is encoded by: hsa:94005
has only substance units: false
has part: Q9H490
is: SBO:0000297
initial concentration: NaN
is encoded by: hsa:128869
has part: Q969N2
constant: false

metaR TTDCAtr
reversible: true
is described by: ECO:0000269
product: MODEL1310110024#
name: tetradecanoate (transport)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false

metaM o2 m
is: HMDB01377
has only substance units: false
is: CHEBI:15379
initial concentration: 1.0
is: C00007
initial amount: NaN
boundary condition: false
name: O2
constant: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
type: Species
is: SBO:0000247

metaR r1109
fast: false
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000000
kinetic law: MODEL1310110024#
is: SBO:0000176
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:

metaR PHEACGLNt
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14681857 NOTES:SAB
is: SBO:0000185
type: Reaction
reactant: MODEL1310110024#
product: MODEL1310110024#
name: PHEACGLN extracellular transport via diffusion

metaM dcamp c
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
name: N6-(1,2-Dicarboxyethyl)-AMP
is: CHEBI:57567
type: Species
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
is: HMDB00536
is: C03794
is: SBO:0000247
initial concentration: 1.0

metaM dlnlcgcrn c
type: Species
is: SBO:0000247
constant: false
is: CHEBI:16004
initial amount: NaN
is: HMDB01311
name: dihomo-gamma-linolenyl carnitine
has only substance units: false
notes: FORMULA: C27H47NO4 CHARGE: 0 INCHI: InChI=1/C27H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,25H,5-8,11,14,17-24H2,1-4H3
boundary condition: false
initial concentration: 1.0

metaM rib D e
is: HMDB00283
name: D-ribose
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:16988
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaM hom L c
constant: false
is: SBO:0000247
name: L-homoserine
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
boundary condition: false
has only substance units: false
is: HMDB00719
is: CHEBI:15699
initial amount: NaN
type: Species
initial concentration: 1.0

metaR MI1P Dtn
reactant: MODEL1310110024#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110024#
product: MODEL1310110024#
name: inositol 1-phosphate nuclear transport (diffusion)
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110024#_5b900a10_399e_4e2e_acf7_330346221c92
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: Q8TF08
name: COX7B2
constant: false
type: Species
boundary condition: true
is encoded by: hsa:170712
has only substance units: false

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

metaR r2510
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reactant: MODEL1310110024#
name: Utilized transport
reversible: true
product: MODEL1310110024#
kinetic law: MODEL1310110024#
is: SBO:0000185

metaR MI14P4P
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
product: MODEL1310110024#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110024#
name: inositol-1,4-bisphosphate 4-phosphatase
kinetic law: MODEL1310110024#
reversible: false
is described by: ECO:0000000
fast: false

metaR DOLPMT4 Ler
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110024#
reversible: false
kinetic law: MODEL1310110024#
product: MODEL1310110024#
is described by: ECO:0000000
fast: false
type: Reaction
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)

metaR FAOXC8DCC6DCx
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8DC-->C6DC)x
type: Reaction

metaM mi134p c
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:58414
has only substance units: false
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243
constant: false
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)
initial amount: NaN
is: HMDB01143

metaR G14T2g
type: Reaction
reversible: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
product: MODEL1310110024#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000
modifier: MODEL1310110024#

metaM hexdicoa x
has only substance units: false
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
name: hexadecanedioylcoa
boundary condition: false
initial amount: NaN
is: HMDB02288

metaM HC02205 c
is: CHEBI:28099
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
name: prostaglandin-b2
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954

metaR RE1448N
fast: false
reactant: MODEL1310110024#
reversible: true
name: RE1448
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
type: Reaction
is described by: ECO:0000000
product: MODEL1310110024#
is: SBO:0000176

metaM tymsf e
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB06409
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
name: Tyramine O-sulfate
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)

metaR VACCCPT2
name: carnitine transferase
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
product: MODEL1310110024#
is: SBO:0000176

metaR r1148
product: MODEL1310110024#
reactant: MODEL1310110024#
type: Reaction
fast: false
reversible: true
name: Active transport
is described by: ECO:0000000
kinetic law: MODEL1310110024#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

metaR VALLAT1tc
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Valine by LAT1 in association with 4F2hc, across the apical surface of the memebranes.
type: Reaction

metaM dgdp n
is: HMDB00960
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
initial amount: NaN
boundary condition: false
is: CHEBI:58595
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
name: dGDP(2-)

metaR BUP2
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:11508704,PMID:5773299 NOTES:MM
name: beta-ureidopropionase (D-3-amino-isobutanoate forming)
is: SBO:0000176
modifier: MODEL1310110024#
reversible: false
fast: false
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.5.1.6
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
type: Reaction

metaR PCt
name: phosphatidylcholine transporter
is described by: ECO:0000269
modifier: MODEL1310110024#
reactant: MODEL1310110024#
product: MODEL1310110024#
reversible: true
is version of: http://identifiers.org/ec-code/3.6.3.44
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (5244.1) or (5244.3) or (5244.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11826283,PMID:7912658 NOTES:for PC secretion into bile NJ
kinetic law: MODEL1310110024#

metaR r1147
reactant: MODEL1310110024#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110024#
type: Reaction
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
product: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_bd95fc78_c83d_41e3_8871_a5614329a4a3
has only substance units: false
is: SBO:0000252
type: Species
is: P30838
constant: false
is encoded by: hsa:218
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: ALDH3A1

metaM 4ppan c
is: HMDB01016
is: C03492
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
name: D-4'-Phosphopantothenate
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:10986

metaM acnacngalgbside hs g
is: SBO:0000247
is: HMDB00223
initial concentration: 1.0
is: C00036
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:3338
name: disialyl galactosylgloboside
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
type: Species
constant: false

metaM dgdp m
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
name: dGDP(2-)
is: CHEBI:58595
is: HMDB00960
boundary condition: false
is: SBO:0000247

metaR r1966
is: SBO:0000185
modifier: MODEL1310110024#
reactant: MODEL1310110024#
product: MODEL1310110024#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110024#
name: Y+LAT2 Utilized transport
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110024#_3dadcd2f_651c_4595_9c01_2706587b8d92
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:4731
initial concentration: NaN
name: NDUFV3
type: Species

metaM glyc R c
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:16659
is: SBO:0000247
name: D-glycerate
type: Species
is: HMDB00139
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
has only substance units: false

metaM cs a deg5 l
notes: FORMULA: C23H36O24S CHARGE: -2
initial amount: NaN
is: CHEBI:15936
type: Species
is: SBO:0000247
has only substance units: false
constant: false
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 5
initial concentration: 1.0
boundary condition: false

metaM CE2435 m
boundary condition: false
initial concentration: 1.0
is: CHEBI:57795
is: SBO:0000247
name: trans,cis-deca-2,4-dienoyl-CoA
type: Species
has only substance units: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_c9e5a73b_0240_4549_9a29_4833bb3dada1
name: HSD17B10
is: Q99714
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
has only substance units: false
is encoded by: hsa:3028
initial amount: NaN
boundary condition: true

metaM sgalside hs g
name: sulfatide galactocerebroside
is: CHEBI:58343
is: HMDB00061
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
type: Species
has only substance units: false
initial amount: NaN

metaM lnlccrn m
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
has only substance units: false
type: Species
is: HMDB06469
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
name: Linoleyl carnitine
initial concentration: 1.0

metaR FUMTSULtm
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reactant: MODEL1310110024#
name: Fumarate:thiosulfate antiport, mitochondrial
type: Reaction
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
is described by: ECO:0000269
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_1ad088b8_5255_4e47_94de_0e6a13d91f70
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
name: _AW277253_1_c
type: Species
is encoded by: hsa:AW277253

http://identifiers.org/biomodels.db/MODEL1310110024#_65d68b25_d12e_4d8c_be61_1a8b12d001df
constant: false
type: Species
is encoded by: hsa:377841
initial concentration: NaN
is: Q5MY95
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: ENTPD8
has only substance units: false

metaR MANtly
type: Reaction
reversible: false
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
is described by: ECO:0000000
name: mannose efflux from lysosome
is: SBO:0000185
kinetic law: MODEL1310110024#
fast: false
product: MODEL1310110024#

metaR MAN1PT2
is version of: http://identifiers.org/ec-code/2.7.7.13
fast: false
name: mannose-1-phosphate guanylyltransferase (GDP)
kinetic law: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
reactant: MODEL1310110024#
is: SBO:0000176
notes: GENE_ASSOCIATION: (29926.2) or (29926.1) or (29925.2) or (29925.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.22 Confidence Level: 0 AUTHORS: NOTES:JLR
modifier: MODEL1310110024#
is described by: ECO:0000000
reversible: false

metaR DOLMANP Lter
fast: false
product: MODEL1310110024#
reversible: false
reactant: MODEL1310110024#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110024#
type: Reaction
name: dolichol-phosphate mannose flippase (liver)

http://identifiers.org/biomodels.db/MODEL1310110024#_97105339_1267_437b_83ee_3a37fb117744
is: SBO:0000252
name: PAPSS2
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
constant: false
is encoded by: hsa:9060
initial concentration: NaN
is: O95340

metaR MALTe
modifier: MODEL1310110024#
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110024#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.20
kinetic law: MODEL1310110024#
name: alpha-glucosidase, extracellular
fast: false
notes: GENE_ASSOCIATION: (8972.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.20 Confidence Level: 4 AUTHORS: PMID:3143729 NOTES:IF
reactant: MODEL1310110024#

metaR r1965
product: MODEL1310110024#
name: Y+LAT2 Utilized transport
reversible: false
fast: false
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110024#
is: SBO:0000185

metaR r2514
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is: SBO:0000185
fast: false
type: Reaction
name: Utilized transport
product: MODEL1310110024#
reactant: MODEL1310110024#

metaR ADRNCPT1
type: Reaction
modifier: MODEL1310110024#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
product: MODEL1310110024#
is described by: ECO:0000000
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
name: carnitine O-palmitoyltransferase
is version of: http://identifiers.org/ec-code/2.3.1.21

http://identifiers.org/biomodels.db/MODEL1310110024#_0eaaaa08_275e_4894_8291_1692936cc091
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: P30049
name: ATP5D
boundary condition: true
is encoded by: hsa:513
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110024#_f300fd16_31c8_41e6_acc4_fe9d6ad60ada
boundary condition: true
type: Species
name: MAT2B:MAT2A
initial concentration: NaN
is encoded by: hsa:4144
has part: P31153
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:27430
has only substance units: false
constant: false

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

metaR EX mag hs LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Monoacylglycerol 2 (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_ad4ee5e1_2665_45e9_bb68_f75996e07a43
constant: false
is: Q7Z4L0
type: Species
boundary condition: true
is encoded by: hsa:341947
name: COX8C
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110024#_68fa486b_a4dd_4227_be30_ea07d504105a
is: SBO:0000252
is: Q8NFF5
has only substance units: false
initial amount: NaN
is encoded by: hsa:80308
constant: false
initial concentration: NaN
type: Species
boundary condition: true
name: FLAD1

metaR DNDPt30m
kinetic law: MODEL1310110024#
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
fast: false
modifier: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000269
type: Reaction
reversible: false
name: dCDP transport via ADP antiport

metaR IDOAASE1ly
is: SBO:0000176
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
reactant: MODEL1310110024#
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
name: alpha-L-iduronidase, lysosomal
product: MODEL1310110024#
fast: false
is described by: ECO:0000000
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.76

http://identifiers.org/biomodels.db/MODEL1310110024#_43bd24fa_6201_4dc2_818b_8e3203bed244
initial amount: NaN
is encoded by: hsa:7359
has only substance units: false
type: Species
boundary condition: true
name: _7359_1_c
initial concentration: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_b64a5a7a_5c40_4605_aa6a_5dafae308ad0
initial concentration: NaN
type: Species
name: GALNT7
constant: false
is: SBO:0000252
boundary condition: true
is: Q86SF2
is encoded by: hsa:51809
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_66915ee3_51e7_4055_82c1_bb95d5b801a9
constant: false
name: HCST:PIK3CG
boundary condition: true
has part: Q9UBK5
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:10870
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5294
type: Species
has part: P48736

http://identifiers.org/biomodels.db/MODEL1310110024#_74a2758e_110e_4ebb_877d_8d40372d776d
is encoded by: hsa:6470
type: Species
boundary condition: true
initial concentration: NaN
is: P34896
has only substance units: false
is: SBO:0000252
constant: false
name: SHMT1
initial amount: NaN

metaR RE0689E
type: Reaction
reversible: false
product: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.4.3.22
name: RE0689
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:

metaR ADRNCPT2
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine transferase
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
fast: false
product: MODEL1310110024#
modifier: MODEL1310110024#

metaR 4ABUTtm
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110024#
name: 4-aminobutanoate mitochondrial transport via diffusion
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10407778 NOTES:NCD
kinetic law: MODEL1310110024#
is: SBO:0000185

metaM acrn c
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:57589
name: O-acetylcarnitine
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
is: SBO:0000247
has only substance units: false
is: HMDB00201
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_37445d25_94dd_4f66_aed1_46d847c2cce7
is: SBO:0000252
initial amount: NaN
name: SLC9A4
constant: false
is: Q6AI14
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:389015
has only substance units: false

metaM cholcoads x
has only substance units: false
constant: false
is: CHEBI:27505
is: HMDB06889
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C48H74N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h9,23-25,27-34,36,38-40,44,56-58,60-61H,7-8,10-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01466 EHMN_ABBREVIATION: C05460
initial amount: NaN
boundary condition: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110024#_602129fd_edb6_4252_b9e2_fe722150810f
name: CYP27A1
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1593
is: Q02318
constant: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110024#_4565efa7_03df_4a32_9a33_521cc1866578
type: Species
initial concentration: NaN
is encoded by: hsa:1581
initial amount: NaN
constant: false
is: SBO:0000252
name: CYP7A1
is: P22680
has only substance units: false
boundary condition: true

metaM ksi pre15 g
is: HMDB00175
constant: false
notes: FORMULA: C149H240N10O119S4X CHARGE: -5
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 15
boundary condition: false
initial amount: NaN
is: C00130
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110024#_c0e20fb7_c49b_4b02_ab06_30c418afb94c
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
name: AK4
boundary condition: true
initial amount: NaN
is encoded by: hsa:205
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_f0882d01_9777_4d86_9a75_a902f87bb59c
type: Species
is: SBO:0000252
is encoded by: hsa:212
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is: Q5JZF5
name: ALAS2

metaM sgalside hs l
constant: false
name: sulfatide galactocerebroside
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:16349
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
is: HMDB00904

metaM ksii core4 deg1 l
boundary condition: false
initial amount: NaN
is: CHEBI:57737
is: HMDB00868
has only substance units: false
name: keratan sulfate II (core 4-linked), degradation product 1
notes: FORMULA: C78H126N6O64S3X CHARGE: -3
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false

metaR CYTK11n
product: MODEL1310110024#
modifier: MODEL1310110024#
reversible: true
type: Reaction
kinetic law: MODEL1310110024#
is described by: ECO:0000269
fast: false
name: cytidylate kinase (dCMP,dGTP),nuclear
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM gdpmann c
name: GDP-alpha-D-mannose(2-)
is: SBO:0000247
has only substance units: false
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
constant: false
boundary condition: false
is: CHEBI:57527
type: Species
initial amount: NaN
is: HMDB01163
initial concentration: 1.0

metaR r2516
product: MODEL1310110024#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110024#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12739169,PMID:18305372 NOTES:
reactant: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_c45ba4d5_920a_409f_aa54_09d4fa5491cd
has only substance units: false
initial concentration: NaN
name: GMPPA
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:29926
type: Species
constant: false
boundary condition: true

metaR ALACYSNaEx
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
name: L-alanine/L-cysteine Na-dependent exchange (Ala-L in)
modifier: MODEL1310110024#
type: Reaction
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110024#_e7f412b2_ca03_4086_bcae_95699e40c124
name: PPA2
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
is: Q9H2U2
is encoded by: hsa:27068

metaM acetol c
type: Species
has only substance units: false
initial concentration: 1.0
name: hydroxyacetone
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h4H,2H2,1H3
boundary condition: false
is: HMDB06961
is: CHEBI:27957
constant: false

metaM datp c
is: SBO:0000247
is: C00131
boundary condition: false
initial concentration: 1.0
name: dATP
type: Species
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: HMDB01532
is: CHEBI:61404

metaR NACHEX21ly
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110024#
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
reversible: false
product: MODEL1310110024#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
fast: false

metaM tymsf c
is: HMDB06409
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
name: Tyramine O-sulfate
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110024#_3b354a39_09ca_4764_879e_1c99cbdca6b5
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is encoded by: hsa:259230
name: SGMS1
is: D3DWC4
initial amount: NaN

metaM dmnoncrn c
boundary condition: false
name: 4,8-dimethylnonanoyl carnitine
has only substance units: false
initial amount: NaN
notes: FORMULA: C18H37NO4 CHARGE: 0
is: SBO:0000247
constant: false
type: Species
is: HMDB06202
initial concentration: 1.0

metaR r0317
type: Reaction
modifier: MODEL1310110024#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.4
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
reversible: true
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
is version of: http://identifiers.org/ec-code/2.1.2.10
is version of: http://identifiers.org/ec-code/1.4.4.2
reactant: MODEL1310110024#
is described by: ECO:0000000
kinetic law: MODEL1310110024#

metaR BAAT4x
is: SBO:0000176
kinetic law: MODEL1310110024#
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 2 AUTHORS: NOTES:fourth version analog added in similarity to BAAT1x, BAAT2x NJ
modifier: MODEL1310110024#
reversible: false
type: Reaction
is described by: ECO:0000304
name: bile acid Coenzyme A: amino acid N-acyltransferase
reactant: MODEL1310110024#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.65

http://identifiers.org/biomodels.db/MODEL1310110024#_210b47c3_734e_47f4_a3cb_049f8fc7be14
is: P54750
is: SBO:0000252
type: Species
constant: false
name: PDE1A
is encoded by: hsa:5136
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_b5c55706_7cd6_4119_b0bd_6c599a4df768
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:23428
boundary condition: true
name: SLC7A8
has only substance units: false
is: Q9UHI5
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_7a40e4c3_ab41_434a_8d50_333cc11e185a
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
constant: false
name: FLAD1
boundary condition: true
is encoded by: hsa:80308

metaR MECOAS1m
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.4
modifier: MODEL1310110024#
type: Reaction
fast: false
name: mesaconate--CoA ligase (GDP-forming)
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000304

metaR 4PYRDX
type: Reaction
name: 4-Pyridoxal secretion
is described by: ECO:0000000
reactant: MODEL1310110024#
reversible: false
kinetic law: MODEL1310110024#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6380540 NOTES:IT Reaction correct??? (active transport)
fast: false
product: MODEL1310110024#

metaR UDPACGALtl
type: Reaction
reversible: true
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
name: udpacgal intracellular transport
fast: false
product: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - there are UDPACGAL-translocators for ER and Golgi, however no info on lysosomal - poor support for this NJ
is: SBO:0000185
is described by: ECO:0000000

metaR RE3001M
name: RE3001
reactant: MODEL1310110024#
type: Reaction
product: MODEL1310110024#
fast: false
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/1.3.1.34
is: SBO:0000176

metaR PPNCL3
kinetic law: MODEL1310110024#
product: MODEL1310110024#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.2.5
name: phosphopantothenate-cysteine ligase
fast: false
modifier: MODEL1310110024#
reactant: MODEL1310110024#
type: Reaction
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (79717.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR SUCCTD
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

metaM uacgam g
initial concentration: 1.0
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
boundary condition: false
type: Species
is: CHEBI:57705
is: HMDB00290

http://identifiers.org/biomodels.db/MODEL1310110024#_4f315f27_69c0_4675_afbb_762595065cab
has only substance units: false
name: MTMR2
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:8898
is: A6NN98
is: SBO:0000252
initial amount: NaN
type: Species

metaR 5MTAte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
name: Transport of 5-S-methyl-5-thioadenosine
is described by: ECO:0000134
type: Reaction
reversible: true
reactant: MODEL1310110024#
product: MODEL1310110024#
fast: false
kinetic law: MODEL1310110024#

metaM galgbside hs g
boundary condition: false
type: Species
name: galactosylgloboside
initial concentration: 1.0
constant: false
is: CHEBI:18259
initial amount: NaN
has only substance units: false
notes: FORMULA: C50H89N2O27FULLRCO CHARGE: 0
is: SBO:0000247

metaR r1961
is: SBO:0000185
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
reversible: false
modifier: MODEL1310110024#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
product: MODEL1310110024#
reactant: MODEL1310110024#

metaR ST8SIA12
product: MODEL1310110024#
modifier: MODEL1310110024#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
is described by: ECO:0000000
name: Beta-galactoside alpha-2,3-sialyltransferase
fast: false
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.99.8
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#

metaM m1mpdol U c
initial amount: NaN
initial concentration: 1.0
type: Species
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human uterine homolog
has only substance units: false
constant: false
notes: FORMULA: C1305H2140N20O270P20 CHARGE: -20 INCHI: InChI=1S/C53H92N2O27P2/c1-27(2)13-9-14-28(3)15-10-16-29(4)17-11-18-30(5)19-12-20-31(6)21-22-73-83(69,70)82-84(71,72)81-51-39(55-33(8)61)43(65)47(37(26-59)77-51)78-50-38(54-32(7)60)42(64)48(36(25-58)76-50)79-53-46(68)49(41(63)35(24-57)75-53)80-52-45(67)44(66)40(62)34(23-56)74-52/h13,15,17,19,31,34-53,56-59,62-68H,9-12,14,16,18,20-26H2,1-8H3,(H,54,60)(H,55,61)(H,69,70)(H,71,72)/b28-15+,29-17+,30-19+/t31?,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47-,48-,49+,50+,51-,52-,53+/m1/s1
is: CHEBI:28067
boundary condition: false
is: SBO:0000247

metaR 2OXOADOXm
product: MODEL1310110024#
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) (mitochondria)
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.2.4.2
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.8.1.4
is described by: ECO:0000304
type: Reaction
notes: GENE_ASSOCIATION: (4967.1) and (1738.1 and 8050.1) and (1743.1) or (4967.2) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Lysine metabolism EC Number: 2.3.1.61 Confidence Level: 2 AUTHORS: NOTES:SAB
is version of: http://identifiers.org/ec-code/2.3.1.61
fast: false

metaR r2378
is described by: ECO:0000000
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
reversible: true
product: MODEL1310110024#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
is: SBO:0000185
fast: false

metaR CORE4GTg
modifier: MODEL1310110024#
reactant: MODEL1310110024#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.102
fast: false
name: Core 4 beta6-GalNAc-transferase, Golgi apparatus
kinetic law: MODEL1310110024#
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (9245.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.148 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110024#_7830fb96_1c70_44ed_a01e_dfc44fc0c5bd
initial concentration: NaN
is encoded by: hsa:107
boundary condition: true
is: Q08828
initial amount: NaN
constant: false
is: SBO:0000252
name: ADCY1
type: Species
has only substance units: false

metaR EX cspg b LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan exchange
type: Reaction

metaR r0728
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
type: Reaction
is described by: ECO:0000000
product: MODEL1310110024#
is: SBO:0000176
reversible: true

metaR r1547
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110024#
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110024#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110024#
fast: false

metaM eipencoa x
name: 2,5,8,11,14-eicosapentaenoylcoa
notes: FORMULA: C41H60N7O17P3S CHARGE: -4
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/24892790
type: Species

metaR ESTRADIOLt
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
fast: false
product: MODEL1310110024#
name: estradiol transport

http://identifiers.org/biomodels.db/MODEL1310110024#_baa39394_0238_4bc3_8cf0_47c34d976c85
name: NDUFB4
initial amount: NaN
is encoded by: hsa:4710
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
is: O95168

metaR EX sfcys LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for sulfocysteine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_5f6487a2_ffe2_4e45_aef3_3f9d18e14b56
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
name: NDUFS8
initial concentration: NaN
is: O00217
is encoded by: hsa:4728

metaR S6TASE1ly
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110024#
reversible: true
is: SBO:0000176
fast: false
is described by: ECO:0000000
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110024#
modifier: MODEL1310110024#
name: N-acetylglucosamine-6-sulfatase, lysosomal
type: Reaction

metaR r2519
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
product: MODEL1310110024#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110024#
name: Utilized transport
fast: false
kinetic law: MODEL1310110024#
type: Reaction

metaR r2379
is described by: ECO:0000000
product: MODEL1310110024#
reversible: true
is: SBO:0000185
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110024#
type: Reaction
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

metaM tststerone r
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
boundary condition: false
initial concentration: 1.0
name: testosterone
initial amount: NaN
has only substance units: false
is: CHEBI:17347
constant: false
is: HMDB00234
is: SBO:0000247
type: Species

metaM leuktrE4 c
constant: false
is: HMDB02200
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
name: leukotriene E4(1-)
is: SBO:0000247
is: CHEBI:57462
type: Species

metaR r1546
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
product: MODEL1310110024#
is: SBO:0000185
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

metaM dtdp n
constant: false
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
is: HMDB01274
type: Species
initial amount: NaN
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
boundary condition: false
is: CHEBI:58369
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaM mmcoa S m
is: CHEBI:57327
name: (S)-methylmalonyl-CoA(5-)
has only substance units: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13+,16+,17+,18-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00495
initial concentration: 1.0
boundary condition: false
is: HMDB02310
type: Species
initial amount: NaN
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110024#_1454d31f_68b3_4c98_af92_a5015145440a
constant: false
name: NDUFB8
is: SBO:0000252
boundary condition: true
is: O95169
is encoded by: hsa:4714
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN

metaR RE2666C
fast: false
name: RE2666
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7930586 NOTES:
reactant: MODEL1310110024#
is described by: ECO:0000000
reversible: false
product: MODEL1310110024#
is: SBO:0000176
kinetic law: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_53ebf492_0a6c_4f70_9854_b731723b6f79
constant: false
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:2882
initial amount: NaN
is: SBO:0000252
is: Q96SL4
name: GPX7
initial concentration: NaN

metaR r0021
is: SBO:0000176
kinetic law: MODEL1310110024#
fast: false
reversible: true
reactant: MODEL1310110024#
is described by: ECO:0000000
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
modifier: MODEL1310110024#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.5
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
product: MODEL1310110024#

metaM 4nphsf e
constant: false
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
type: Species
is: SBO:0000247
is: CHEBI:35422
name: 4-Nitrophenyl sulfate
initial concentration: 1.0
boundary condition: false
is: HMDB06492
initial amount: NaN
has only substance units: false

metaM 3mb2coa m
boundary condition: false
is: SBO:0000247
has only substance units: false
name: 3-methylbut-2-enoyl-CoA(4-)
initial amount: NaN
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069
type: Species
is: CHEBI:57344
constant: false
is: HMDB01493
initial concentration: 1.0

metaM hexdicoa r
is: SBO:0000247
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
constant: false
type: Species
boundary condition: false
has only substance units: false
is: HMDB00672
name: hexadecanedioylcoa
is: C08260
initial concentration: 1.0
initial amount: NaN

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

metaR DPCOAK
is version of: http://identifiers.org/ec-code/2.7.7.3
is described by: ECO:0000269
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
fast: false
name: dephospho-CoA kinase
product: MODEL1310110024#
kinetic law: MODEL1310110024#
type: Reaction
reversible: false
reactant: MODEL1310110024#

metaM dolp L r
is: SBO:0000247
constant: false
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
name: dolichyl phosphate(2-)
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:57683
initial amount: NaN
type: Species

metaM sphmyln hs c
boundary condition: false
constant: false
name: sphingomyelin betaine
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
is: CHEBI:58216

metaR r2376
is described by: ECO:0000000
product: MODEL1310110024#
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110024#
type: Reaction
is: SBO:0000185

metaM f1a l
type: Species
has only substance units: false
constant: false
notes: FORMULA: C22H37N2O15X CHARGE: 0
name: F1alpha
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17151
is: SBO:0000247
is: HMDB02917

metaR S6TASE13ly
fast: false
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.14
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
name: N-acetylglucosamine-6-sulfatase, lysosomal
modifier: MODEL1310110024#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction

metaR 3SPYRSPm
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM
name: 3-sulfinopyruvate hydrolase (spotaneous reaction), mitochondrial
product: MODEL1310110024#
reversible: false
type: Reaction

metaR r1549
reversible: true
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110024#
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR FMNAT
is: SBO:0000176
name: FMN adenylyltransferase
reactant: MODEL1310110024#
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
is version of: http://identifiers.org/ec-code/2.7.7.2
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
fast: false
reversible: false
product: MODEL1310110024#

metaR FAOXC102C81x
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)x
type: Reaction

metaM dtdp m
name: dTDP
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB01274
is: CHEBI:58369
type: Species
initial amount: NaN
initial concentration: 1.0
is: C00363

metaM uacgam c
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:57705
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
initial concentration: 1.0
has only substance units: false
is: HMDB00290
constant: false

metaR r0022
reversible: true
is described by: ECO:0000000
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
product: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
type: Reaction
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/1.8.1.7
is: SBO:0000176

metaR GLYCLTtp
reversible: false
kinetic law: MODEL1310110024#
product: MODEL1310110024#
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
type: Reaction
reactant: MODEL1310110024#
name: glycolate transport into peroxisome

metaR ST8SIA11
is: SBO:0000176
kinetic law: MODEL1310110024#
is described by: ECO:0000000
product: MODEL1310110024#
reactant: MODEL1310110024#
type: Reaction
name: Beta-galactoside alpha-2,3-sialyltransferase
modifier: MODEL1310110024#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.4.99.8

metaR r1259
type: Reaction
is: SBO:0000176
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reversible: false
fast: false
kinetic law: MODEL1310110024#
product: MODEL1310110024#
is described by: ECO:0000000
name: EC:6.2.1.3

metaR Ser Thrtg
kinetic law: MODEL1310110024#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
product: MODEL1310110024#
reversible: true
reactant: MODEL1310110024#
name: Ser/Thr transport (from golgi to lysosome)
is described by: ECO:0000269
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110024#_0253273f_55cd_4686_9b46_ef502ca36233
is encoded by: hsa:5277
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
type: Species
is: B3KUV7
name: PIGA

metaR DM gpi sig er
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gpi sig(er)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_c7042531_35a6_468b_9089_0a88e45348d6
name: MAOB
initial amount: NaN
is encoded by: hsa:4129
has only substance units: false
is: SBO:0000252
is: P27338
constant: false
initial concentration: NaN
boundary condition: true
type: Species

metaM pmtcoa x
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
is: C00154
is: HMDB01338
type: Species
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
name: Palmitoyl-CoA (n-C16:0CoA)
initial concentration: 1.0
is: CHEBI:57379

http://identifiers.org/biomodels.db/MODEL1310110024#_adc060ea_0b7b_4099_ab0e_7dd8aa0352b5
is encoded by: hsa:6532
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: SLC6A4
type: Species
is: P31645
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_991e128f_6203_480a_9896_6fe5ef2afcd4
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
name: VNN3
is encoded by: hsa:55350

metaR r2377
type: Reaction
product: MODEL1310110024#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110024#

metaR r1548
kinetic law: MODEL1310110024#
type: Reaction
fast: false
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110024#
is: SBO:0000185
reactant: MODEL1310110024#

metaR GLYLEUHYDROc
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: hydrolysis of Glycylleucine in the small intestine for cellular uptake
type: Reaction

metaR PAPStg
reversible: true
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110024#
product: MODEL1310110024#
fast: false
reactant: MODEL1310110024#
name: 3'-Phosphoadenylyl sufate Golgi transport
kinetic law: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_cca8fea9_477e_4c12_ae5e_7e2c435c8e59
has only substance units: false
is encoded by: hsa:4125
type: Species
is: O00754
initial amount: NaN
name: MAN2B1
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false

metaM 4nphsf c
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
name: 4-Nitrophenyl sulfate
is: CHEBI:35422
is: HMDB06492
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)

metaR r0027
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.39
reactant: MODEL1310110024#
is described by: ECO:0000000
product: MODEL1310110024#
modifier: MODEL1310110024#
type: Reaction
reversible: true
kinetic law: MODEL1310110024#
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
is: SBO:0000176

metaM 10fthf5glu e
name: 10-formyltetrahydrofolate-[Glu](5)
boundary condition: false
notes: FORMULA: C40H45N11O19 CHARGE: -6
has only substance units: false
is: CHEBI:58190
type: Species
constant: false
is: HMDB00224
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110024#_ef7576be_25ad_41e8_8f1f_7de97818d664
boundary condition: true
type: Species
is: SBO:0000252
name: DPM2
initial concentration: NaN
is encoded by: hsa:8818
initial amount: NaN
is: O94777
has only substance units: false
constant: false

metaR sink 5hpet LPAREN c RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: sink reaction for 5(S)-HPETE(1-)
type: Reaction

metaR EX leuleu LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylleucine
type: Reaction

metaR r2374
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110024#
reversible: true
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110024#
type: Reaction
product: MODEL1310110024#

metaM g3p c
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3930
name: Glyceraldehyde 3-phosphate
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB01112
is: SBO:0000247
is: CHEBI:58027
is: C00661
type: Species

metaR r0724
product: MODEL1310110024#
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reversible: true
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.33
modifier: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_097c7a13_2627_4f2c_996a_c8e24c9cd7ef
initial amount: NaN
is: SBO:0000252
name: ALG2
has only substance units: false
constant: false
is encoded by: hsa:85365
is: Q9H553
initial concentration: NaN
boundary condition: true
type: Species

metaR RE1826C
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110024#
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:
type: Reaction
name: RE1826
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110024#_3ad828f1_b581_4f7d_b416_ffe580c89bad
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:2203
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: Q2TU34
constant: false
name: FBP1

metaM dolmanp U c
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
is: CHEBI:15809
name: Dolichyl phosphate D-mannose, human uterine homolog
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
initial amount: NaN
has only substance units: false

metaR r0311
reversible: false
product: MODEL1310110024#
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110024#
is: SBO:0000176
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.9
kinetic law: MODEL1310110024#
is described by: ECO:0000000
modifier: MODEL1310110024#

metaR GLNTHRNaEx
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
kinetic law: MODEL1310110024#
product: MODEL1310110024#
is: SBO:0000185
fast: false
reactant: MODEL1310110024#
name: L-threonine/L-glutamine Na-dependent exchange (Gln-L in)
modifier: MODEL1310110024#

metaR AMETt2m
is described by: ECO:0000269
product: MODEL1310110024#
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (115286.3) or (115286.2) or (115286.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14674884 NOTES:Added by RS/TV (6/17/05)
modifier: MODEL1310110024#
type: Reaction
reversible: true
reactant: MODEL1310110024#
name: S-Adenosyl-L-methionine reversible transport, mitochondrial
fast: false
is: SBO:0000185

metaR GLNtm
type: Reaction
reactant: MODEL1310110024#
product: MODEL1310110024#
name: L-glutamine transport via electroneutral transporter
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)
kinetic law: MODEL1310110024#
is: SBO:0000185
fast: false

metaR GTHOm
is version of: http://identifiers.org/ec-code/1.8.1.7
name: glutathione oxidoreductase
reactant: MODEL1310110024#
modifier: MODEL1310110024#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558,PMID:15149466 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
product: MODEL1310110024#
type: Reaction
reversible: false
is described by: ECO:0000254
kinetic law: MODEL1310110024#
fast: false

metaM retinol c
is: HMDB00305
boundary condition: false
initial amount: NaN
type: Species
name: retinol
has only substance units: false
is: SBO:0000247
is: CHEBI:50211
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
constant: false
initial concentration: 1.0

metaM glyc R m
initial concentration: 1.0
name: D-glycerate
is: HMDB00139
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
boundary condition: false
constant: false
is: CHEBI:16659
type: Species
has only substance units: false

metaM CE4792 m
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-22,24,28-30,34,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4792
constant: false
is: CHEBI:57923
name: 3-oxo-cis-8-tetradecenoyl-CoA

metaM sbcoa x
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
is: http://identifiers.org/pubchem.compound/16019966
boundary condition: false
name: suberylcoa
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_96703c12_233e_4aba_9af1_61992caaa7b8
has only substance units: false
is encoded by: hsa:7167
is: SBO:0000252
constant: false
type: Species
boundary condition: true
is: Q53HE2
initial amount: NaN
initial concentration: NaN
name: TPI1

metaR r1144
kinetic law: MODEL1310110024#
fast: false
reactant: MODEL1310110024#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.18.6.3
modifier: MODEL1310110024#
is: SBO:0000185
product: MODEL1310110024#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10823827 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110024#_62d5034e_7461_4eef_8608_ed1bc78d47a3
has only substance units: false
boundary condition: true
is: E9PB82
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:3295
initial concentration: NaN
type: Species
name: HSD17B4

metaR r1811
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110024#
product: MODEL1310110024#
is: SBO:0000185
name: Y+LAT2 Utilized transport
type: Reaction
reversible: false

metaR EX uri LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Uridine
type: Reaction

metaR GALASE1ly
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false
product: MODEL1310110024#
modifier: MODEL1310110024#
name: beta-galactosidase, lysosomal
kinetic law: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110024#
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110024#_37d03b6e_ca80_4274_aa26_81137fbf019a
is: Q96Q11
name: TRNT1
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:51095

metaR r2375
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
kinetic law: MODEL1310110024#
fast: false
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
is: SBO:0000185
product: MODEL1310110024#

metaM HC02205 e
boundary condition: false
is: CHEBI:28099
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
name: prostaglandin-b2
constant: false
initial concentration: 1.0
has only substance units: false

metaM ksi deg31 l
is: CHEBI:57455
name: keratan sulfate I, degradation product 31
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB01354
notes: FORMULA: C90H148N6O72S2 CHARGE: -2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110024#_09a46d8c_4ffa_45f0_b725_2a84d21f9dea
is: A1L4Q0
initial concentration: NaN
type: Species
constant: false
name: DGKE
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:8526
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110024#_39843e42_c5c3_4212_9b0b_5c4717828890
initial concentration: NaN
is: SBO:0000297
has only substance units: false
has part: Q8NCI4
name: PIGF:PIGG
constant: false
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:54872

metaR PCm
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (5091.1) or (5091.2) SUBSYSTEM: Pyruvate metabolism EC Number: 6.4.1.1 Confidence Level: 4 AUTHORS: PMID:6548474 NOTES:TV Metabolism at a glance
name: pyruvate carboxylase
modifier: MODEL1310110024#
is version of: http://identifiers.org/ec-code/6.4.1.1
type: Reaction
reversible: false
product: MODEL1310110024#
kinetic law: MODEL1310110024#
is: SBO:0000176
fast: false
is described by: ECO:0000269

metaR GLAl
reversible: false
kinetic law: MODEL1310110024#
is: SBO:0000176
fast: false
modifier: MODEL1310110024#
notes: GENE_ASSOCIATION: (2717.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.22 Confidence Level: 4 AUTHORS: PMID:11775551,PMID:11828341,PMID:15003450,PMID:2836863 NOTES:NJ
product: MODEL1310110024#
name: galactosidase, alpha
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/3.2.1.22
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_1ce9b985_a4c9_41ca_be21_60e4a2a3528d
has only substance units: false
type: Species
constant: false
boundary condition: true
is encoded by: hsa:8854
is: F5H2Y9
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: ALDH1A2

metaM HC01118 r
is: SBO:0000247
is: CHEBI:57310
constant: false
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
initial amount: NaN
boundary condition: false
name: presqualene diphosphate(3-)
has only substance units: false
initial concentration: 1.0
type: Species

metaR r2372
type: Reaction
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
reactant: MODEL1310110024#
is: SBO:0000185
product: MODEL1310110024#
kinetic law: MODEL1310110024#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaR B3GALT5g
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (10317.4) or (10317.1) or (10317.3) or (10317.2) or (10317.5) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
product: MODEL1310110024#
name: Beta-1,3-galactosyltransferase 5
is described by: ECO:0000269
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
reactant: MODEL1310110024#
reversible: false

metaR r0726
is version of: http://identifiers.org/ec-code/2.7.1.33
modifier: MODEL1310110024#
product: MODEL1310110024#
reversible: true
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110024#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
fast: false
kinetic law: MODEL1310110024#

metaR r1810
product: MODEL1310110024#
reversible: false
reactant: MODEL1310110024#
is described by: ECO:0000000
kinetic law: MODEL1310110024#
is: SBO:0000185
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110024#
fast: false
type: Reaction

metaR HSD3B7P
type: Reaction
name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
product: MODEL1310110024#
reversible: false
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.181
reactant: MODEL1310110024#
modifier: MODEL1310110024#

metaM bilirub r
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
initial amount: NaN
is: HMDB00054
is: SBO:0000247
type: Species
constant: false
is: CHEBI:57977
name: bilirubin(2-)
boundary condition: false

metaR r1143
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10823827 NOTES:
reactant: MODEL1310110024#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.18.6.3
is: SBO:0000185
reversible: false
product: MODEL1310110024#
type: Reaction
modifier: MODEL1310110024#
kinetic law: MODEL1310110024#
fast: false

metaR CO2t
fast: false
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
is: SBO:0000185
product: MODEL1310110024#
kinetic law: MODEL1310110024#
name: CO2 transporter via diffusion

http://identifiers.org/biomodels.db/MODEL1310110024#_15a88435_4d79_492d_8f8e_014705663666
initial concentration: NaN
is: Q92959
is: SBO:0000252
is encoded by: hsa:6578
constant: false
type: Species
initial amount: NaN
name: SLCO2A1
has only substance units: false
boundary condition: true

metaM r5p c
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: C00117
constant: false
is: CHEBI:18189
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
has only substance units: false
is: HMDB00618
name: alpha-D-Ribose 5-phosphate
type: Species

metaR DOLPMT3 Ler
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.260
modifier: MODEL1310110024#
fast: false
product: MODEL1310110024#
reversible: false
reactant: MODEL1310110024#
is: SBO:0000176
kinetic law: MODEL1310110024#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)

metaM sgalside hs c
is: CHEBI:16523
has only substance units: false
type: Species
name: sulfatide galactocerebroside
boundary condition: false
initial amount: NaN
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
constant: false
is: HMDB03406
is: SBO:0000247
initial concentration: 1.0

metaR r1544
is: SBO:0000185
reactant: MODEL1310110024#
is described by: ECO:0000000
product: MODEL1310110024#
type: Reaction
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110024#_4d21032a_7b2e_4c14_9c6d_a83b08b8af87
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: Q16836
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:3033
name: HADH
type: Species

metaR PHYCBOXL
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 4.1.1.28 Confidence Level: 1 AUTHORS: NOTES:SAB
is described by: ECO:0000212
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.28
type: Reaction
modifier: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
fast: false
name: L-Phenylalanine carboxy-lyase
reversible: false

metaR DURIPP
is described by: ECO:0000269
kinetic law: MODEL1310110024#
product: MODEL1310110024#
modifier: MODEL1310110024#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
fast: false
reactant: MODEL1310110024#
is version of: http://identifiers.org/ec-code/2.4.2.1
name: deoxyuridine phosphorylase
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.3

http://identifiers.org/biomodels.db/MODEL1310110024#_64b4027f_a92e_4cdd_b8fa_7b7dac36652b
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:27430
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: MAT2B
is: Q9NZL9

metaR EX sprm LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_sprm(e)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_09e0a5ba_3d7a_4c02_b41b_0488fd15d44b
boundary condition: true
is encoded by: hsa:83549
name: UCK1
initial amount: NaN
is: Q5JT09
is: SBO:0000252
type: Species
has only substance units: false
constant: false
initial concentration: NaN

metaR AG13T6g
product: MODEL1310110024#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reactant: MODEL1310110024#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#

metaM octdececoa c
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
name: octadecenoylcoa
is: HMDB06351

metaR r2373
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110024#
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110024#
reversible: true
product: MODEL1310110024#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110024#_146d8c8f_e0cb_4f8f_bd4d_cc4c13c147a2
is encoded by: hsa:U37519
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
name: _U37519_1_c
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110024#_17cdc9f9_ffe7_4bdd_bc00_310686eb2288
constant: false
is encoded by: hsa:3550
boundary condition: true
name: IK
is: SBO:0000252
initial amount: NaN
is: Q13123
type: Species
initial concentration: NaN
has only substance units: false

metaM Lkynr c
is: HMDB00684
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:16946
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
constant: false
initial amount: NaN
name: L-kynurenine
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110024#_f19e0456_ddce_4f39_bf1f_028e47151e79
is encoded by: hsa:84649
initial concentration: NaN
is: Q96PD7
type: Species
name: DGAT2
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

metaR NDP8
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110024#
fast: false
name: nucleoside-diphosphatase (dUDP)
reversible: false
is version of: http://identifiers.org/ec-code/2.7.4.9
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110024#
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
type: Reaction

metaM acetone e
constant: false
is: SBO:0000247
boundary condition: false
name: acetone
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
is: HMDB01659
is: CHEBI:15347

metaR r2371
type: Reaction
reversible: true
is described by: ECO:0000000
product: MODEL1310110024#
reactant: MODEL1310110024#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110024#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaM gpi hs r
has only substance units: false
constant: false
is: CHEBI:16038
is: SBO:0000247
name: {[PE-Man-],[PE-]Man},{PE-}Man-GlcN-acylPI
type: Species
notes: FORMULA: C55H106N4O38P4FULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaM pi l
boundary condition: false
is: CHEBI:43474
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB00973
name: hydrogenphosphate
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
constant: false
type: Species

metaR r0720
kinetic law: MODEL1310110024#
name: (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
type: Reaction
is described by: ECO:0000000
product: MODEL1310110024#
is: SBO:0000176
reactant: MODEL1310110024#
reversible: false

metaR O2tp
reversible: true
is: SBO:0000185
name: O2 transport, peroxisomal
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110024#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110024#
kinetic law: MODEL1310110024#

http://identifiers.org/biomodels.db/MODEL1310110024#_bb72f06f_6a18_46ab_b8a1_a7ff2a74777e
initial concentration: NaN
constant: false
name: PGM2
is encoded by: hsa:55276
has only substance units: false
is: Q96G03
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species

metaR FAOXC181C161m
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:1-->C16:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_d7490725_defb_4121_a6cb_4a0a73e17a77
boundary condition: true
constant: false
is: P48448
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
name: ALDH3B2
initial amount: NaN
is encoded by: hsa:222

http://identifiers.org/biomodels.db/MODEL1310110024#_141c770a_1097_4712_8efc_2627ef05a2d4
boundary condition: true
initial concentration: NaN
is: Q7GXZ1
has only substance units: false
initial amount: NaN
name: ND6
type: Species
is encoded by: hsa:4541
is: SBO:0000252
constant: false

metaR LALDO2x
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:AMF
type: Reaction
is: SBO:0000176
fast: false
name: D-Lactaldehyde:NAD+ 1-oxidoreductase
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110024#
product: MODEL1310110024#
kinetic law: MODEL1310110024#

metaR FAOXC102C81m
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_3228df83_be7b_4d5d_84b6_8cd971f6adbc
type: Species
has only substance units: false
name: NDUFB2
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
is: H7C5B8
is encoded by: hsa:4708

http://identifiers.org/biomodels.db/MODEL1310110024#_aad61415_fa13_462b_855d_c02292bdc741
constant: false
is encoded by: hsa:8897
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
name: MTMR3
is: SBO:0000252
initial amount: NaN

metaR r1551
fast: false
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110024#
product: MODEL1310110024#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_bf74f191_245c_40b9_a917_396ad499ebcd
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:47
boundary condition: true
initial concentration: NaN
has only substance units: false
name: ACLY

metaM dcyt c
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB00014
constant: false
is: C00881
is: CHEBI:15698
name: Deoxycytidine
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881

metaR FAOXC161C141x
kinetic law: MODEL1310110024#
product: MODEL1310110024#
reactant: MODEL1310110024#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C16:1-->C14:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110024#_1ae548ff_54dc_4013_a9e4_3679f138bb7a
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
is: Q12882
is encoded by: hsa:1806
boundary condition: true
initial amount: NaN
has only substance units: false
name: DPYD

http://identifiers.org/biomodels.db/MODEL1310110024#_59000f71_88f0_4814_9784_924736c03454
constant: false
initial amount: NaN
name: _AI818585_1_c
boundary condition: true
is encoded by: hsa:AI818585
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false

metaR SAMHISTA
name: S-Adenosyl-L-methionine:histamine N-tele-methyltransferase
kinetic law: MODEL1310110024#
notes: GENE_ASSOCIATION: (3176.1) SUBSYSTEM: Histidine metabolism EC Number: 2.1.1.8 Confidence Level: 4 AUTHORS: PMID:7943261 NOTES:SAB R02155
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.1.8
fast: false
is described by: ECO:0000269
product: MODEL1310110024#
modifier: MODEL1310110024#
type: Reaction
reactant: MODEL1310110024#

metaR r0723
is version of: http://identifiers.org/ec-code/2.3.1.41
reactant: MODEL1310110024#
product: MODEL1310110024#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is described by: ECO:0000000
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110024#
fast: false
modifier: MODEL1310110024#

metaR RE2759X
product: MODEL1310110024#
is version of: http://identifiers.org/ec-code/5.1.99.4
name: RE2759
type: Reaction
reversible: true
reactant: MODEL1310110024#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23600.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.1.99.4 Confidence Level: 0 AUTHORS: PMID:11060344,PMID:11060359 NOTES:
fast: false
kinetic law: MODEL1310110024#
modifier: MODEL1310110024#
is: SBO:0000176

metaM HC02210 c
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
type: Species
is: CHEBI:34939
boundary condition: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
initial amount: NaN
name: prostaglandin-d3

metaR EX xyl D LPAREN e RPAREN
kinetic law: MODEL1310110024#
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Xylose exchange
type: Reaction

metaR MM5cg
reactant: MODEL1310110024#
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110024#
is described by: ECO:0000000
modifier: MODEL1310110024#
reversible: false
product: MODEL1310110024#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
is version of: http://identifiers.org/ec-code/3.2.1.113

metaR O2tm
reactant: MODEL1310110024#
reversible: true
kinetic law: MODEL1310110024#
name: O2 transport (diffusion)
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
product: MODEL1310110024#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000

metaR SUCCt2m
modifier: MODEL1310110024#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
kinetic law: MODEL1310110024#
fast: false
reactant: MODEL1310110024#
type: Reaction
reversible: true
is: SBO:0000185
name: succinate transport, mitochondrial
product: MODEL1310110024#

metaM na1 e
is: C01330
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB00588
name: Sodium
notes: FORMULA: Na CHARGE: 1
is: CHEBI:4541
type: Species
constant: false
has only substance units: false