http://identifiers.org/biomodels.db/MODEL1310110023#_9a04e306_9343_4444_8f99_36c0b6a9fe20
has only substance units: false
name: ADCY7
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
is: P51828
is encoded by: hsa:113
boundary condition: true
initial amount: NaN

metaR PI45P3K
reactant: MODEL1310110023#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110023#
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.1.153
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5293.1 and 8503.1) or (5296.1 and 5290.1) or (5293.1 and 5295.1) or (5293.1 and 5295.3) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (5295.2 and 5290.1) or (10870.1 and 5294.1) or (23533.1 and 5294.1) or (5295.2 and 5293.1) or (5290.1 and 5295.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (5291.1 and 8503.1) or (5293.1 and 5296.1) or (5295.2 and 5291.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.153 Confidence Level: 4 AUTHORS: PMID:12507995,PMID:15780590,PMID:2174051,PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989 NOTES:NCD
type: Reaction
name: phosphatidylinositol 4,5-bisphosphate 3-kinase
is version of: http://identifiers.org/ec-code/2.7.11.1
reversible: false
fast: false
modifier: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_355b1c55_006b_4c48_9c13_261e895bee4b
name: C1GALT1
is: Q9NS00
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:56913
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_2353070f_c85f_489c_a473_f645e1376d74
type: Species
has only substance units: false
name: GALT
constant: false
is: SBO:0000252
initial concentration: NaN
is: B2RAT6
boundary condition: true
is encoded by: hsa:2592
initial amount: NaN

metaR r0680
reversible: true
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110023#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110023#
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.3.1.137
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_7b778035_44ca_4d82_83e9_caf4645e5fa9
name: NDUFA2
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
is: O43678
is: SBO:0000252
is encoded by: hsa:4695
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_0864992b_51c7_4700_b81f_7a97236322ef
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:55350
constant: false
boundary condition: true
type: Species
name: VNN3
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_bf45ed00_3dcd_4906_bb6b_4a6b29e19520
boundary condition: true
type: Species
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:C7orf24
initial amount: NaN
initial concentration: NaN
name: _C7orf24_1_m

http://identifiers.org/biomodels.db/MODEL1310110023#_55a86895_8396_4f0f_af61_965f5d612fcf
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:30061
constant: false
name: SLC40A1
initial concentration: NaN
is: Q9NP59
boundary condition: true

metaM prostgf2 c
name: prostaglandin F2alpha(1-)
initial concentration: 1.0
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB01139
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:57404

metaR r1421
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
product: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000185
name: Free diffusion
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_36594cd9_8dcd_4d2b_806f_d778006f2b24
is: Q9Y2C3
constant: false
boundary condition: true
is: SBO:0000252
name: B3GALT5
initial concentration: NaN
has only substance units: false
is encoded by: hsa:10317
type: Species
initial amount: NaN

metaR FAOXC185m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_d3f6220f_eb06_4e0f_91f3_89e7bf3f9a54
is: Q9NPC4
is: SBO:0000252
is encoded by: hsa:53947
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
name: A4GALT
constant: false

metaM n2m2nmasn e
type: Species
is: C04946
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C58H96N5O40X CHARGE: 0

metaR LEULEUPEPT1tc
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylleucine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_4784d00c_07aa_4881_bf5f_ab9fb45cf284
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:AI024818
is: SBO:0000252
name: _AI024818_1_c
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_metaR_EX_s2l2fn2m2masn_LPAREN_e_RPAREN_
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: PA6 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_34f3145c_35eb_4ad9_8316_b1c66db8901f
boundary condition: true
initial concentration: NaN
constant: false
name: PIK3CB:PIK3R1
has part: B4DER4
initial amount: NaN
is encoded by: hsa:5291
type: Species
has part: B3KT19
has only substance units: false
is encoded by: hsa:5295
is: SBO:0000297

metaR DOLPMT4 Uer
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
product: MODEL1310110023#
kinetic law: MODEL1310110023#
reversible: false
fast: false
reactant: MODEL1310110023#
is described by: ECO:0000000
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)

http://identifiers.org/biomodels.db/MODEL1310110023#_ef2d54fb_4f18_42df_bbda_4a066ff92bac
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
name: _AI440329_1_r
initial concentration: NaN
is encoded by: hsa:AI440329
boundary condition: true

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_810e5726_d0f7_487e_b20c_b340c786c22c
initial amount: NaN
is: SBO:0000252
is: B7Z6Q4
type: Species
is encoded by: hsa:3612
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
name: IMPA1

http://identifiers.org/biomodels.db/MODEL1310110023#_bb362797_39fc_43dd_b7d6_82127258b134
initial amount: NaN
is encoded by: hsa:55276
boundary condition: true
name: PGM2
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is: Q96G03
is: SBO:0000252

metaR FACOAL1812
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000
product: MODEL1310110023#
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110023#
modifier: MODEL1310110023#
reversible: true
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
kinetic law: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_726ce7dd_bd6f_4deb_ac62_17f7eb12250d
initial amount: NaN
name: _AA203143_1_c
constant: false
initial concentration: NaN
is encoded by: hsa:AA203143
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species

metaM ksi pre31 g
is: HMDB00175
notes: FORMULA: C227H363N16O189S9X CHARGE: -10
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 31
boundary condition: false
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
is: C00130
is: CHEBI:58053
initial concentration: 1.0

metaM 3pg c
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58272
has only substance units: false
is: C00197
is: http://identifiers.org/pubchem.compound/3497
is: HMDB00807
type: Species
name: 3-Phospho-D-glycerate
constant: false

metaM glyclt x
initial concentration: 1.0
has only substance units: false
is: CHEBI:29805
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
boundary condition: false
is: SBO:0000247
constant: false
type: Species
is: HMDB00115
initial amount: NaN
name: glycolate

metaR LNLCCRNt
modifier: MODEL1310110023#
reactant: MODEL1310110023#
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110023#
name: transport into the mitochondria (carnitine)
fast: false
product: MODEL1310110023#

metaR LEUt5m
is: SBO:0000185
reversible: true
fast: false
kinetic law: MODEL1310110023#
name: leucine mitochondrial transport
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_73b4f114_97bf_49b4_b36e_ecb1953a5a23
boundary condition: true
has only substance units: false
is encoded by: hsa:AA081045
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
name: _AA081045_1_e
type: Species

metaR r0170
reactant: MODEL1310110023#
fast: false
is described by: ECO:0000000
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
reversible: true
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
kinetic law: MODEL1310110023#
type: Reaction
product: MODEL1310110023#
is: SBO:0000176
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.1.40

metaM HC02206 e
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
initial amount: NaN
constant: false
is: CHEBI:57399
name: prostaglandin C1(1-)

http://identifiers.org/biomodels.db/MODEL1310110023#_d31bb114_2cd2_40d1_95aa_10d2729a36f7
name: PIGQ
is encoded by: hsa:9091
has only substance units: false
is: B2RAU6
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species

metaR NTD6
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
type: Reaction
product: MODEL1310110023#
name: 5'-nucleotidase (dAMP)
is version of: http://identifiers.org/ec-code/3.1.3.5
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is described by: ECO:0000134
is: SBO:0000176
modifier: MODEL1310110023#
reversible: false
fast: false

metaM glyc m
is: CHEBI:17754
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
boundary condition: false
name: Glycerol
is: SBO:0000247
constant: false
is: HMDB00131
is: C00116
type: Species

metaR ALATHRNaEx
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
kinetic law: MODEL1310110023#
name: L-alanine/L-threonine Na-dependent exchange (Ala-L in)
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110023#
modifier: MODEL1310110023#
reactant: MODEL1310110023#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_7a1231c9_86a2_4a9a_938c_b1ed5e446fdb
initial concentration: NaN
name: PEMT
type: Species
has only substance units: false
constant: false
is encoded by: hsa:10400
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaM prostgf2 e
constant: false
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
name: prostaglandin F2alpha(1-)
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB01139
is: CHEBI:57404

http://identifiers.org/biomodels.db/MODEL1310110023#_0403b8f5_000a_4967_8ba4_9ed763a9c3c4
initial amount: NaN
initial concentration: NaN
constant: false
is: F8WDN9
has only substance units: false
boundary condition: true
name: PPA2
type: Species
is: SBO:0000252
is encoded by: hsa:27068

metaR SADT
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.1.25
fast: false
type: Reaction
modifier: MODEL1310110023#
product: MODEL1310110023#
name: sulfate adenylyltransferase

http://identifiers.org/biomodels.db/MODEL1310110023#_53a4d5b7_32e7_44dd_a74a_bbb2ef7df8e1
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:D29675
type: Species
boundary condition: true
name: _D29675_1_c
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_52fb247d_d125_4876_9566_bce7e0614004
initial amount: NaN
is: SBO:0000252
name: ALDH3A1
type: Species
is encoded by: hsa:218
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is: P30838

http://identifiers.org/biomodels.db/MODEL1310110023#_f18693c2_20d2_4214_aa53_5c9ccf0590b2
constant: false
initial amount: NaN
name: NDUFA8
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
is: B1AM93
initial concentration: NaN
is encoded by: hsa:4702

metaM methf c
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:57455
type: Species
boundary condition: false
is: HMDB01354
is: C00445
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
initial amount: NaN
name: 5,10-Methenyltetrahydrofolate

http://identifiers.org/biomodels.db/MODEL1310110023#_c6ec6a9b_ee1d_4e9b_ad5f_bf5d028f8e90
name: CPT1B
constant: false
is: SBO:0000252
is encoded by: hsa:1375
has only substance units: false
boundary condition: true
initial concentration: NaN
is: Q53FV7
initial amount: NaN
type: Species

metaR r0494
is: SBO:0000176
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
kinetic law: MODEL1310110023#
fast: false
product: MODEL1310110023#
reactant: MODEL1310110023#
type: Reaction
is described by: ECO:0000000
reversible: true

metaR GUAPRT
type: Reaction
reactant: MODEL1310110023#
reversible: false
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110023#
fast: false
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.4.2.8
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine and 6-mercaptopurine can replace hypoxanthine EC added (2.4.2.7 makes the same reaction) IT
name: guanine phosphoribosyltransferase
kinetic law: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_45f050f2_074c_4088_80bb_6171e3671304
initial concentration: NaN
is: P15104
initial amount: NaN
name: GLUL
is encoded by: hsa:2752
constant: false
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110023#_d05b1d90_2d4a_463f_bac5_8950b907d82d
constant: false
type: Species
is encoded by: hsa:9167
is: SBO:0000252
name: COX7A2L
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
is: Q6FGA0

http://identifiers.org/biomodels.db/MODEL1310110023#_edb70b37_88e3_4f20_8769_7b8e705216f2
boundary condition: true
is encoded by: hsa:4724
is: O43181
type: Species
name: NDUFS4
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_d5477078_d5c0_46de_be1b_bb0c5e6236dd
constant: false
name: IDI1
is: Q13907
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3422
type: Species

metaR r0801
fast: false
is: SBO:0000185
reversible: true
type: Reaction
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
kinetic law: MODEL1310110023#
product: MODEL1310110023#
modifier: MODEL1310110023#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
is version of: http://identifiers.org/ec-code/1.2.1.5

metaM formcoa c
constant: false
is: CHEBI:57376
is: HMDB03419
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
name: formyl-CoA(4-)
notes: FORMULA: C22H32N7O17P3S CHARGE: -4 INCHI: InChI=1S/C22H36N7O17P3S/c1-22(2,17(33)20(34)25-4-3-13(31)24-5-6-50-11-30)8-43-49(40,41)46-48(38,39)42-7-12-16(45-47(35,36)37)15(32)21(44-12)29-10-28-14-18(23)26-9-27-19(14)29/h9-12,15-17,21,32-33H,3-8H2,1-2H3,(H,24,31)(H,25,34)(H,38,39)(H,40,41)(H2,23,26,27)(H2,35,36,37)/p-4/t12-,15-,16-,17+,21-/m1/s1 EHMN_ABBREVIATION: C00798
initial concentration: 1.0

metaR 2HBO
product: MODEL1310110023#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.27
is: SBO:0000176
type: Reaction
reactant: MODEL1310110023#
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (92483.1) or (3948.2) or (55293.1) or (3945.1 and 3939.1) or (3939.1) or (160287.1) or (3945.1) or (3948.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:10108,PMID:21765 NOTES:NCD
name: 2-Hydroxybutyrate:NAD+ oxidoreductase
reversible: true
kinetic law: MODEL1310110023#

metaM uacgam g
is: SBO:0000247
is: CHEBI:57705
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
type: Species
is: HMDB00290
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043

metaR r1981
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110023#
fast: false
modifier: MODEL1310110023#
reversible: false
reactant: MODEL1310110023#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110023#
name: Y+LAT2 Utilized transport

metaR S6T9g
fast: false
is described by: ECO:0000000
modifier: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
reactant: MODEL1310110023#
product: MODEL1310110023#
kinetic law: MODEL1310110023#

metaR DESAT20 2
reversible: false
fast: false
reactant: MODEL1310110023#
modifier: MODEL1310110023#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
name: fatty acyl-CoA desaturase (n-C20:4CoA -> n-C20:5CoA)
type: Reaction
is described by: ECO:0000000
product: MODEL1310110023#
kinetic law: MODEL1310110023#

metaR FAOXC225x
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_4440e253_d3bd_4edf_95d0_8ccc1677622e
is: SBO:0000252
name: LHPP
is encoded by: hsa:64077
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is: Q9H008
type: Species
constant: false

metaM gtp m
is: CHEBI:37565
initial amount: NaN
is: HMDB01273
constant: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: SBO:0000247
is: C00044
name: GTP
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110023#_ecac80d3_d4ed_46ce_999a_a629259050d6
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
name: MCEE
is: Q96PE7
has only substance units: false
constant: false
is encoded by: hsa:84693
initial concentration: NaN

metaR ACt2r
product: MODEL1310110023#
fast: false
name: acetate reversible transport via proton symport
kinetic law: MODEL1310110023#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
reactant: MODEL1310110023#
is: SBO:0000185
reversible: true

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaR r0683
modifier: MODEL1310110023#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
is: SBO:0000176
type: Reaction
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
fast: false
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
reversible: false

metaM lac L x
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:16651
name: (S)-lactate
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB00190
initial amount: NaN

metaM gtp n
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:37565
type: Species
has only substance units: false
name: GTP(4-)
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
initial amount: NaN
is: HMDB01273

http://identifiers.org/biomodels.db/MODEL1310110023#_9b5d5177_71e1_4b22_8cf8_62d79fcfe7f5
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: SLC37A4
is: A8K0S7
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2542
type: Species

metaM glyc e
initial concentration: 1.0
type: Species
name: Glycerol
has only substance units: false
is: SBO:0000247
is: HMDB00131
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
constant: false
initial amount: NaN
is: CHEBI:17754
is: C00116
boundary condition: false

metaM 4hphac e
boundary condition: false
is: SBO:0000247
name: 4-hydroxyphenylacetate
is: CHEBI:48999
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: HMDB00020
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110023#_4b6e1ec0_e959_4afa_8a6f_639dfc95a215
is: SBO:0000252
has only substance units: false
name: AACS
constant: false
initial amount: NaN
is encoded by: hsa:65985
type: Species
is: Q86V21
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_a56e1f26_6742_42c6_ac28_c1ead49685b6
type: Species
is: P14060
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: HSD3B1
is encoded by: hsa:3283
boundary condition: true
is: SBO:0000252
constant: false

metaM ocdca e
name: octadecanoate (n-C18:0)
constant: false
is: HMDB00827
is: C01530
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:25629
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaR CHOLt4
fast: false
reactant: MODEL1310110023#
name: choline, sodium cotransport
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110023#
product: MODEL1310110023#
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110023#_9030ddfa_3df8_45b3_9c4d_f147f0d72ea4
is: SBO:0000252
is encoded by: hsa:271
boundary condition: true
initial amount: NaN
name: AMPD2
constant: false
initial concentration: NaN
is: Q01433
has only substance units: false
type: Species

metaM guln c
boundary condition: false
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB03290
type: Species
has only substance units: false
name: L-gulonate
is: CHEBI:13115
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110023#_06bd6a05_c627_48d8_a09e_e5fe1f40de87
initial concentration: NaN
type: Species
is encoded by: hsa:1543
boundary condition: true
is: SBO:0000252
name: CYP1A1
is: A0N0X8
initial amount: NaN
has only substance units: false
constant: false

metaM dgtp n
is: CHEBI:16497
is: C00286
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: dGTP
is: HMDB01440
type: Species
constant: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_ddd5d9e5_6102_41f1_8327_70ec96f85c82
name: PMM2
is encoded by: hsa:5373
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is: O15305
boundary condition: true
is: SBO:0000252

metaR GGH 7DHFe
modifier: MODEL1310110023#
name: Gamma-glutamyl hydrolase (7DHF), extracellular
is: SBO:0000176
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
product: MODEL1310110023#
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.4.19.9
reactant: MODEL1310110023#
type: Reaction
is described by: ECO:0000000
reversible: false
fast: false

metaR GLNTHRNaEx
modifier: MODEL1310110023#
type: Reaction
name: L-threonine/L-glutamine Na-dependent exchange (Gln-L in)
is described by: ECO:0000269
reversible: false
product: MODEL1310110023#
is: SBO:0000185
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaR COQ6m
product: MODEL1310110023#
type: Reaction
is: SBO:0000176
fast: false
name: Ubiquinone biosynthesis monooxgenase COQ6
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (51004.1) or (51004.2) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_1.13.12.- IT
reversible: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110023#_6cc2f7ba_741e_4973_a2a9_61193d384fc3
boundary condition: true
initial amount: NaN
has only substance units: false
is: P05187
is encoded by: hsa:250
is: SBO:0000252
name: ALPP
type: Species
constant: false
initial concentration: NaN

metaM HC02206 c
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:57399
constant: false
initial concentration: 1.0
name: prostaglandin C1(1-)

metaM CE5119 m
is: CHEBI:57923
type: Species
initial amount: NaN
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: trans-3-cis-8-tetradecadienoyl-CoA
constant: false

metaR MALSO4tm
reversible: true
reactant: MODEL1310110023#
is described by: ECO:0000269
modifier: MODEL1310110023#
type: Reaction
is: SBO:0000185
name: Malate:sulfate antiport, mitochondrial
kinetic law: MODEL1310110023#
product: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110023#_637d673a_65ce_4d30_9064_1c9fa26428d7
name: DAD1:DDOST:RPN1:RPN2
initial amount: NaN
is: SBO:0000297
has only substance units: false
has part: P39656
has part: P04844
is encoded by: hsa:1650
has part: Q53G02
type: Species
has part: P04843
constant: false
is encoded by: hsa:1603
is encoded by: hsa:6185
is encoded by: hsa:6184
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_58f16824_438f_4e17_b6e5_578432587fa8
is: G0W2N5
constant: false
name: SLC14A1
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6563
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_f29a4776_cd7b_4a79_b51b_ef4167fa41df
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: Q9GZR5
is: SBO:0000252
is encoded by: hsa:6785
name: ELOVL4
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_42793246_f172_490f_a88b_5f0d2d10fa4c
boundary condition: true
is encoded by: hsa:3614
constant: false
initial amount: NaN
type: Species
is: C9JV30
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: IMPDH1

metaR ATPH2e
notes: GENE_ASSOCIATION: (954.2) or (954.1) or (953.1) or (956.1) or (955.1) or (957.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.5 Confidence Level: 4 AUTHORS: PMID:8955160,PMID:9676430 NOTES:IT
type: Reaction
reversible: false
name: ATP diphosphohydrolase
is described by: ECO:0000269
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.6.1.5
is version of: http://identifiers.org/ec-code/3.6.1.6
is: SBO:0000176
modifier: MODEL1310110023#
fast: false
product: MODEL1310110023#

metaM methf m
constant: false
boundary condition: false
is: HMDB01354
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:57455
is: SBO:0000247
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
initial concentration: 1.0
name: (6R)-5,10-methenyltetrahydrofolate

http://identifiers.org/biomodels.db/MODEL1310110023#_c1ed02e8_c7e7_4ef7_8ef5_a7afea6e294a
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
name: _R39999_1_c
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:R39999

http://identifiers.org/biomodels.db/MODEL1310110023#_6ab3e026_f459_4fe0_b2eb_9c8b011fe517
is encoded by: hsa:5288
initial concentration: NaN
boundary condition: true
has only substance units: false
name: PIK3C2G
is: O75747
is: SBO:0000252
initial amount: NaN
type: Species
constant: false

metaR r1651
kinetic law: MODEL1310110023#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110023#
product: MODEL1310110023#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110023#

metaR SMS
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/2.7.8.27
type: Reaction
fast: false
product: MODEL1310110023#
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (259230.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14685263 NOTES:NJ
is: SBO:0000176
modifier: MODEL1310110023#
name: Sphingomyelin synthase (homo sapiens)

http://identifiers.org/biomodels.db/MODEL1310110023#_4617174e_7ce2_4b2c_99fb_056e4602cbf1
is encoded by: hsa:1892
is: P30084
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: ECHS1
type: Species
constant: false
boundary condition: true

metaR EX pglyc hs LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylglycerol (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_f3ace4f8_e45b_4cf5_bf97_7662a1d7415b
type: Species
boundary condition: true
is encoded by: hsa:8622
constant: false
is: SBO:0000252
is: O95263
has only substance units: false
name: PDE8B
initial concentration: NaN
initial amount: NaN

metaM 4hphac c
has only substance units: false
is: HMDB00020
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:48999
constant: false
name: 4-hydroxyphenylacetate
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
type: Species

metaR r2317
reactant: MODEL1310110023#
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_fc80a844_a3f1_4de9_ab86_1d063bee952c
constant: false
is: SBO:0000252
initial amount: NaN
is: Q92959
has only substance units: false
name: SLCO2A1
is encoded by: hsa:6578
type: Species
boundary condition: true
initial concentration: NaN

metaM gchola c
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
constant: false
is: HMDB00138
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:58235
boundary condition: false
has only substance units: false
name: glycocholate
is: SBO:0000247

metaR r1652
type: Reaction
product: MODEL1310110023#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110023#
reactant: MODEL1310110023#
fast: false
reversible: true
kinetic law: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_9895d3fe_b287_4d90_8bcb_cf0df1af5419
type: Species
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:M68895
initial amount: NaN
name: _M68895_1_c

metaM hdcoa m
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
boundary condition: false
is: HMDB06532
name: Hexadecenoyl-CoA (n-C16:1CoA)

metaR CLS hs
type: Reaction
modifier: MODEL1310110023#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
name: cardiolipin synthase (homo sapiens)
product: MODEL1310110023#
is: SBO:0000176
notes: GENE_ASSOCIATION: (54675.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10799718 NOTES:NJ
fast: false

metaM xu1p D c
is: HMDB06534
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h3,5-7,9H,1-2H2,(H2,10,11,12)/t3-,5-/m1/s1
type: Species
name: D-Xylulose 1-phosphate
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0

metaM ksi deg24 l
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
is: HMDB00143
initial concentration: 1.0
name: keratan sulfate I, degradation product 24
is: CHEBI:12936
type: Species
is: SBO:0000247
notes: FORMULA: C118H191N8O101S5 CHARGE: -5

metaM ksi deg11 l
name: keratan sulfate I, degradation product 11
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:12936
constant: false
initial amount: NaN
is: HMDB00143
notes: FORMULA: C180H289N12O158S9 CHARGE: -9
initial concentration: 1.0
type: Species

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

metaR EX ksii core4 LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 4-linked) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_d2f39bb4_1f17_4029_8724_21bb93f0d18a
name: GGT2
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:728441
initial concentration: NaN
constant: false
initial amount: NaN

metaM rib D e
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: D-ribose
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
is: HMDB00283
is: CHEBI:16988

metaM hpdca c
is: SBO:0000247
type: Species
notes: FORMULA: C17H33O2 CHARGE: -1 INCHI: InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)/p-1
is: HMDB02259
constant: false
initial concentration: 1.0
name: margarate
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:32366

metaR r2316
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
fast: false
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110023#
is described by: ECO:0000000
reactant: MODEL1310110023#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_86e7ceb2_aaca_4fe1_a45b_f2e4b5428d3c
is encoded by: hsa:4728
has only substance units: false
type: Species
initial amount: NaN
is: O00217
constant: false
initial concentration: NaN
name: NDUFS8
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110023#_43135c85_cad2_4461_ad19_6642113f85aa
initial amount: NaN
is: SBO:0000252
is: Q16222
name: UAP1
boundary condition: true
has only substance units: false
is encoded by: hsa:6675
initial concentration: NaN
type: Species
constant: false

metaM crn x
constant: false
is: CHEBI:16347
boundary condition: false
has only substance units: false
type: Species
name: L-Carnitine
initial concentration: 1.0
is: C00318
is: SBO:0000247
is: HMDB00062
initial amount: NaN
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318

http://identifiers.org/biomodels.db/MODEL1310110023#_07295946_1c50_4ecd_ae8f_86736b1b4030
is encoded by: hsa:10841
is: O95954
boundary condition: true
initial concentration: NaN
name: FTCD
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false

metaR r1988
product: MODEL1310110023#
is: SBO:0000185
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
modifier: MODEL1310110023#
type: Reaction
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110023#_d1aa3fd1_025c_4dad_9b38_1ef98470baf2
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
boundary condition: true
name: CAD
is encoded by: hsa:790
is: P27708
initial amount: NaN

metaM eipencoa x
initial amount: NaN
boundary condition: false
is: HMDB02288
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
name: 2,5,8,11,14-eicosapentaenoylcoa
constant: false
notes: FORMULA: C41H60N7O17P3S CHARGE: -4

metaR MTHFDm
is: SBO:0000176
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.3.4.3
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.5.4.9
fast: false
kinetic law: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
reactant: MODEL1310110023#
reversible: true
product: MODEL1310110023#

metaR r2315
reversible: true
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
fast: false
product: MODEL1310110023#
is: SBO:0000185

metaR RE1527M
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110023#
modifier: MODEL1310110023#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110023#
fast: false
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
is: SBO:0000176
name: RE1527

metaR UDPACGALtl
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - there are UDPACGAL-translocators for ER and Golgi, however no info on lysosomal - poor support for this NJ
reversible: true
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
reactant: MODEL1310110023#
product: MODEL1310110023#
name: udpacgal intracellular transport

metaM ptth c
initial amount: NaN
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
initial concentration: 1.0
has only substance units: false
name: pantetheine
boundary condition: false
constant: false
type: Species
is: HMDB03426
is: CHEBI:16753
is: SBO:0000247

metaM glyc c
has only substance units: false
is: C00116
boundary condition: false
is: CHEBI:17754
name: Glycerol
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: HMDB00131
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species

metaM gchola e
notes: FORMULA: C26H43NO6 CHARGE: 0
name: glycocholate
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00138

metaM grdp c
is: CHEBI:58057
notes: FORMULA: C10H17O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00288 EHMN_ABBREVIATION: C00341
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB01285
is: C00341
type: Species
name: Geranyl diphosphate
initial amount: NaN
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110023#_bb661490_716b_4c7c_9e7e_3f8e075331c2
initial amount: NaN
type: Species
is: Q14642
has only substance units: false
is encoded by: hsa:3632
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
name: INPP5A

metaR r0809
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1550832,PMID:8438778 NOTES:
kinetic law: MODEL1310110023#
type: Reaction
reactant: MODEL1310110023#
modifier: MODEL1310110023#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.85
name: Facilitated diffusion
reversible: true
is: SBO:0000185
product: MODEL1310110023#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_ef1cbcaf_36a3_47f9_8f65_ea2afb6adfd9
name: KL
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:9365
has only substance units: false
type: Species
boundary condition: true
is: Q9UEF7
constant: false

metaR r1650
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110023#
reversible: true
kinetic law: MODEL1310110023#
fast: false
reactant: MODEL1310110023#

metaM 34dhoxmand m
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
is: HMDB01866
is: SBO:0000247
name: 3,4-Dihydroxymandelate
is: CHEBI:27637
type: Species

metaM n2m2nmasn l
has only substance units: false
boundary condition: false
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
is: C04946
initial concentration: 1.0
constant: false
notes: FORMULA: C58H96N5O40X CHARGE: 0
is: SBO:0000247
initial amount: NaN
type: Species

metaR FAOXC225m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)m
type: Reaction

metaM 4mptnl m
type: Species
initial amount: NaN
is: CHEBI:17998
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
name: 4-methylpentanal
initial concentration: 1.0
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373
is: HMDB01318

metaR r2314
type: Reaction
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
fast: false
product: MODEL1310110023#
is: SBO:0000185
reactant: MODEL1310110023#
is described by: ECO:0000000

metaM cholcoads x
is: SBO:0000247
is: CHEBI:27505
type: Species
notes: FORMULA: C48H74N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h9,23-25,27-34,36,38-40,44,56-58,60-61H,7-8,10-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01466 EHMN_ABBREVIATION: C05460
initial amount: NaN
boundary condition: false
constant: false
is: HMDB06889
initial concentration: 1.0
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA
has only substance units: false

metaM rib D c
is: HMDB00283
is: CHEBI:16988
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
name: D-ribose
initial amount: NaN
type: Species
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119

metaM hpdca e
name: margarate
is: HMDB02259
notes: FORMULA: C17H33O2 CHARGE: -1 INCHI: InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)/p-1
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
is: CHEBI:32366

metaM crn r
is: HMDB00062
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: CHEBI:16347
name: (R)-carnitine
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR RE2972M
is described by: ECO:0000000
kinetic law: MODEL1310110023#
fast: false
reactant: MODEL1310110023#
name: RE2972
type: Reaction
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.67
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:
modifier: MODEL1310110023#

metaR r2313
reactant: MODEL1310110023#
is: SBO:0000185
fast: false
product: MODEL1310110023#
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
type: Reaction

metaR PRO Dtde
reactant: MODEL1310110023#
type: Reaction
kinetic law: MODEL1310110023#
name: D-proline transport, extracellular
is described by: ECO:0000134
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
product: MODEL1310110023#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_de2468d2_846f_4ba0_b5a7_36322f79edfe
name: PDE9A
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:5152
is: SBO:0000252
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_d29e811c_a48d_4ff2_b5cd_904bc48646ab
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:2678
is: P19440
initial concentration: NaN
is: SBO:0000252
name: GGT1
type: Species
initial amount: NaN

metaR CYSO
type: Reaction
name: cysteine oxidase
modifier: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000269
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.13.11.20
reversible: false
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (1036.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES:IT
kinetic law: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_d0e1802e_2376_41db_9aac_1ba1f5b8066e
is encoded by: hsa:6565
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: SLC15A2
has only substance units: false
constant: false
is: Q16348

metaR DESAT20 1
modifier: MODEL1310110023#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110023#
reversible: false
name: fatty acyl-CoA desaturase (n-C20:3CoA -> n-C20:4CoA)
type: Reaction
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
product: MODEL1310110023#
kinetic law: MODEL1310110023#
fast: false

metaM pristanal x
boundary condition: false
is: CHEBI:49189
name: pristanal
has only substance units: false
is: HMDB01958
type: Species
constant: false
notes: FORMULA: C19H38O CHARGE: 0 INCHI: InChI=1S/C19H38O/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20/h15-19H,6-14H2,1-5H3
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaM pmtcoa c
constant: false
is: C00154
is: CHEBI:3454
boundary condition: false
initial amount: NaN
name: Palmitoyl-CoA (n-C16:0CoA)
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB01338
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_4ce9176f_3907_4cd0_97e3_fac6a746e315
initial amount: NaN
boundary condition: true
is: B3KRT1
constant: false
is encoded by: hsa:51477
has only substance units: false
type: Species
name: ISYNA1
is: SBO:0000252
initial concentration: NaN

metaM gtp e
is: CHEBI:37565
name: GTP(4-)
constant: false
initial amount: NaN
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: HMDB01273
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110023#_caa72166_78c3_4eb4_97eb_e86bb4344ef2
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:2348
name: FOLR1
type: Species

metaM Rtotalcoa c
constant: false
boundary condition: false
name: R total Coenzyme A
has only substance units: false
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
type: Species
is: HMDB01448
is: CHEBI:16189
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaR PHEMEt
product: MODEL1310110023#
is described by: ECO:0000269
modifier: MODEL1310110023#
fast: false
name: heme transport
reversible: false
reactant: MODEL1310110023#
is: SBO:0000185
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (113235.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:16143108 NOTES:NCD
type: Reaction

metaR r2312
is: SBO:0000185
fast: false
product: MODEL1310110023#
reversible: true
kinetic law: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110023#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110023#_9958ec9f_4451_494d_849e_72327eab9583
has only substance units: false
is: SBO:0000252
is encoded by: hsa:203
name: AK1
boundary condition: true
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is: P00568

metaR DESAT22 1p
is: SBO:0000176
name: fatty acyl-CoA desaturase (n-C22:4CoA -> n-C22:5CoA)
fast: false
type: Reaction
product: MODEL1310110023#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
reversible: false
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#

metaR CYTK1n
is: SBO:0000176
reversible: true
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110023#
modifier: MODEL1310110023#
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP),nuclear
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_da90959b_755a_4b61_a6e1_d79b1f796559
is: Q9NY65
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: EHHADH
type: Species
is encoded by: hsa:1962

http://identifiers.org/biomodels.db/MODEL1310110023#_df95a766_10b4_431c_935f_e291ea6976d5
name: SLC35B2
is: Q8TB61
initial concentration: NaN
is encoded by: hsa:347734
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species

metaM 4mzym int1 r
is: SBO:0000247
has only substance units: false
notes: FORMULA: C29H46O3 CHARGE: 0 INCHI: InChI=1/C29H46O3/c1-18(2)8-7-9-19(3)21-11-12-22-20-10-13-24-28(5,23(20)14-16-27(21,22)4)17-15-25(30)29(24,6)26(31)32/h8,19,21-22,24-25,30H,7,9-17H2,1-6H3,(H,31,32)/t19-,21?,22?,24?,25-,27+,28+,29-/m0/s1
initial concentration: 1.0
type: Species
boundary condition: false
name: 4-Methylzymosterol intermediate 1
initial amount: NaN
constant: false
is: HMDB06927

http://identifiers.org/biomodels.db/MODEL1310110023#_81f0e89e_1bb9_4beb_afe3_85879183ab34
is encoded by: hsa:H77542
constant: false
initial concentration: NaN
type: Species
name: _H77542_1_r
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaR ARACHFATPc
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: Uptake of arachidate by the enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_8493a0b1_8c67_4f8e_ad29_e90fb3bfcfca
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
name: _F23536_1_m
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:F23536

metaR r2311
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
product: MODEL1310110023#
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
reversible: true
is described by: ECO:0000000

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

metaM phe L c
constant: false
is: HMDB00159
boundary condition: false
has only substance units: false
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
is: SBO:0000247
is: CHEBI:17295
name: L-phenylalanine
initial amount: NaN
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_c8dd9831_6271_4bff_b752_6742bc69ac04
type: Species
boundary condition: true
is encoded by: hsa:170712
initial concentration: NaN
constant: false
is: SBO:0000252
is: Q8TF08
name: COX7B2
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_044f78ff_e65b_45b5_98e4_71b30d3ce311
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2194
constant: false
initial amount: NaN
type: Species
name: FASN
is: P49327

http://identifiers.org/biomodels.db/MODEL1310110023#_4cc23559_9617_4e62_96c0_266d837394f3
initial concentration: NaN
is: SBO:0000252
is: E7ET30
type: Species
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:50808
name: AK3

metaR r1318
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is: SBO:0000185
reactant: MODEL1310110023#
name: Transport reaction
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110023#
product: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_f4d12bab_baf5_437f_b57c_b2874c143400
constant: false
is: G3XAD7
type: Species
has only substance units: false
is encoded by: hsa:1583
name: CYP11A1
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR HSAT2ly
is: SBO:0000185
fast: false
reactant: MODEL1310110023#
name: heparan-glucosaminide N-acetyltransferase, lysosomal
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
product: MODEL1310110023#
kinetic law: MODEL1310110023#
type: Reaction

metaM taur x
name: taurine
is: HMDB00251
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C2H7NO3S CHARGE: 0 INCHI: InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00222 EHMN_ABBREVIATION: C00245
boundary condition: false
is: CHEBI:15891

metaR PRGSTRNt
is: SBO:0000185
name: Progesterone transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true
reactant: MODEL1310110023#
type: Reaction
kinetic law: MODEL1310110023#
is described by: ECO:0000000
product: MODEL1310110023#
fast: false

metaM gtp c
is: CHEBI:37565
name: GTP
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB01273
type: Species
is: C00044
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044

metaR r0497
is described by: ECO:0000000
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
reactant: MODEL1310110023#
is: SBO:0000176
fast: false
product: MODEL1310110023#
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.2.4.2
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
reversible: true
type: Reaction

metaM uacgam c
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
has only substance units: false
is: HMDB00290
constant: false
is: CHEBI:57705

metaM CE5160 r
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
name: 3-oxo-cis-9-octadecenoyl-CoA
type: Species
is: CHEBI:57923
is: SBO:0000247
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-26,28,32-34,38,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5160

metaR NDPK3n
fast: false
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
reversible: true
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:CDP),nuclear
reactant: MODEL1310110023#
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
product: MODEL1310110023#
type: Reaction

metaR r2310
is described by: ECO:0000000
kinetic law: MODEL1310110023#
reversible: true
reactant: MODEL1310110023#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
product: MODEL1310110023#

metaR METtec
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
product: MODEL1310110023#
name: L-methionine transport via diffusion (extracellular to cytosol)
reversible: true
type: Reaction
reactant: MODEL1310110023#
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
fast: false
is described by: ECO:0000269
is: SBO:0000185

metaR FAOXTC142TC122m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C14:2-->C12:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_6335b238_f506_4e6e_8260_00c20cef76f3
constant: false
is: SBO:0000252
is: F8VQS7
initial concentration: NaN
name: NDUFA12
initial amount: NaN
has only substance units: false
is encoded by: hsa:55967
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110023#_73b6cc3b_7b00_4e2d_8cd8_82eea3d16735
has only substance units: false
constant: false
initial concentration: NaN
is: Q16774
is encoded by: hsa:2987
name: GUK1
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252

metaM pap c
is: HMDB00061
is: SBO:0000247
constant: false
name: adenosine 3',5'-bismonophosphate(4-)
is: CHEBI:58343
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
initial concentration: 1.0

metaR S6T14g
reversible: false
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is described by: ECO:0000000
fast: false
product: MODEL1310110023#
is: SBO:0000176
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110023#_dafee9a2_1bbb_48e2_ace1_6677d03c39fd
initial concentration: NaN
is encoded by: hsa:AI971036
constant: false
type: Species
name: _AI971036_1_m
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110023#_ec519a3a_5c96_4a08_8805_28c9596e8845
is: SBO:0000252
has only substance units: false
is: E7EPA7
constant: false
boundary condition: true
name: TKT
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:7086

metaM cdp c
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:58069
constant: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
type: Species
boundary condition: false
is: C00112
is: HMDB01546
initial concentration: 1.0
name: CDP

http://identifiers.org/biomodels.db/MODEL1310110023#_b6806dfd_fd3f_4305_8aa2_29ece9c32f6a
is: B2RBR4
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6575
name: SLC20A2

metaR IDOAASE4ly
kinetic law: MODEL1310110023#
name: alpha-L-iduronidase, lysosomal
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.2.1.76
reversible: false
is: SBO:0000176
fast: false

metaM ddcacoa c
is: HMDB03571
name: Dodecanoyl-CoA (n-C12:0CoA)
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:57375
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
has only substance units: false
is: C01832
constant: false

metaM crn m
name: L-Carnitine
is: C00318
is: HMDB00062
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16347
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_15d4e677_a812_46f9_a55a_e303c3c68ff6
is encoded by: hsa:1120
initial amount: NaN
name: CHKB
boundary condition: true
constant: false
is: Q9Y259
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252

metaM lac L c
constant: false
has only substance units: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
initial concentration: 1.0
type: Species
is: HMDB00190
name: (S)-lactate
is: SBO:0000247
is: CHEBI:16651
initial amount: NaN
boundary condition: false

metaM CE2705 n
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
is: CHEBI:15374
initial concentration: 1.0
boundary condition: false
type: Species
name: quinonoid dihydrobiopterin
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB02281

http://identifiers.org/biomodels.db/MODEL1310110023#_cca7342f_3d31_4ca3_8f23_a3953349ab3a
is encoded by: hsa:2597
name: GAPDH
is: E7EUT4
constant: false
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

metaM ksi deg3 l
has only substance units: false
is: HMDB02177
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C233H371N16O205S12 CHARGE: -13
is: CHEBI:36033
name: keratan sulfate I, degradation product 3
initial concentration: 1.0

metaR r1659
modifier: MODEL1310110023#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110023#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000000
fast: false

metaR GLYCtm
reactant: MODEL1310110023#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
product: MODEL1310110023#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
kinetic law: MODEL1310110023#
name: glycerol transport
fast: false

metaM dhf c
is: CHEBI:57451
initial amount: NaN
boundary condition: false
name: 7,8-Dihydrofolate
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB01056
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
is: C00415
is: SBO:0000247

metaR FTHFL
is version of: http://identifiers.org/ec-code/1.5.1.5
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (4522.1) or (286297.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110023#
is described by: ECO:0000134
name: Formate-tetrahydrofolate ligase
is: SBO:0000176
modifier: MODEL1310110023#
type: Reaction
product: MODEL1310110023#

metaM hLkynr c
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227
initial concentration: 1.0
is: SBO:0000247
type: Species
name: 3-hydroxy-L-kynurenine
is: HMDB11631
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:17380

metaM hs deg3 l
notes: FORMULA: C81H117N5O97S10 CHARGE: -12
name: heparan sulfate, degradation product 3
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:16126
has only substance units: false

metaR r1658
product: MODEL1310110023#
is described by: ECO:0000000
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110023#
fast: false
reactant: MODEL1310110023#
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110023#_b09050e6_69db_45ce_a98d_8563fca11aca
has only substance units: false
initial concentration: NaN
name: _AV717590_1_c
boundary condition: true
is encoded by: hsa:AV717590
type: Species
initial amount: NaN
is: SBO:0000252
constant: false

metaR EX crn LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-Carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_d3483087_f379_497f_b0fd_d2cea0e0749e
constant: false
initial amount: NaN
is: Q96M32
boundary condition: true
initial concentration: NaN
is encoded by: hsa:122481
is: SBO:0000252
name: AK7
type: Species
has only substance units: false

metaM pap g
boundary condition: false
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
initial concentration: 1.0
type: Species
is: HMDB00061
name: adenosine 3',5'-bismonophosphate(4-)
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:58343

metaR RDH1
notes: GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES:IT
reversible: true
modifier: MODEL1310110023#
is: SBO:0000176
name: retinol dehydrogenase (all-trans)
kinetic law: MODEL1310110023#
fast: false
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.1.1.315
product: MODEL1310110023#

metaR ABTti
fast: false
name: L-arabinitol transport via passive diffusion
kinetic law: MODEL1310110023#
reversible: false
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110023#_1f1bfc99_e113_44a9_bfd1_5e3f8e26d1c7
initial concentration: NaN
is encoded by: hsa:644
name: BLVRA
is: SBO:0000252
boundary condition: true
is: P53004
has only substance units: false
type: Species
constant: false
initial amount: NaN

metaM cdp e
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:58069
is: HMDB01546
type: Species
name: CDP(3-)
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaM 5oxpro e
type: Species
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1
is: CHEBI:57606
initial amount: NaN
has only substance units: false
is: HMDB00267
constant: false
boundary condition: false
name: 5-oxoprolinate
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110023#_bcc5ea8d_6eba_4fda_86d6_7fd8411694d6
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:196883
is: Q8NFM4
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
name: ADCY4

http://identifiers.org/biomodels.db/MODEL1310110023#_03642acd_4c08_45bc_9e7f_fa1d97b060e3
has only substance units: false
initial amount: NaN
type: Species
is: Q15111
is encoded by: hsa:5334
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: PLCL1

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

metaR r0051
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110023#
product: MODEL1310110023#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.3.5
type: Reaction
modifier: MODEL1310110023#
is: SBO:0000176
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_8bfc43b2_b038_4a74_a7de_d0a0fe3f0b3c
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3098
name: HK1
type: Species
constant: false
is: A8K7J7
initial amount: NaN
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_0e0d0683_3478_4a0a_8f57_2a7f37fecf3f
initial concentration: NaN
name: NDUFA6
is: P56556
is encoded by: hsa:4700
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
constant: false
boundary condition: true

metaR r1657
reactant: MODEL1310110023#
is described by: ECO:0000000
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110023#
product: MODEL1310110023#
type: Reaction
reversible: true

metaM s2l2fn2m2masn e
name: PA6
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:3554
type: Species
is: HMDB00244
constant: false
is: SBO:0000247
notes: FORMULA: C90H145N6O65X CHARGE: -2
is: C00255
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110023#_11bd2b98_3d5b_4b08_a2a0_31ca42681f3c
type: Species
constant: false
is encoded by: hsa:8813
name: DPM3:DPM1:DPM2
has part: Q86TM7
has part: O94777
initial concentration: NaN
is encoded by: hsa:8818
has only substance units: false
is encoded by: hsa:54344
boundary condition: true
initial amount: NaN
is: SBO:0000297
has part: O60762

metaR PPCOAOm
name: Propanoyl-CoA:FAD 2,3-oxidoreductase, mitochondrial
reactant: MODEL1310110023#
product: MODEL1310110023#
modifier: MODEL1310110023#
is described by: ECO:0000269
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (80724.1) or (27034.1) or (36.1) or (35.1) or (84129.1) or (34.1) or (28976.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:12359132,PMID:12359260,PMID:15560374,PMID:2565344,PMID:3035565,PMID:7698750,PMID:8276399 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
is: SBO:0000176

metaR ICDHyrm
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
name: Isocitrate dehydrogenase (NADP+)
reversible: true
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.1.1.42
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
product: MODEL1310110023#
fast: false
modifier: MODEL1310110023#
reactant: MODEL1310110023#

metaR FAOXTC101TC102m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C10:1-->C10:2)m
type: Reaction

metaM dhf e
is: SBO:0000247
has only substance units: false
name: dihydrofolate(2-)
is: HMDB01056
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
initial amount: NaN
constant: false
is: CHEBI:57451

http://identifiers.org/biomodels.db/MODEL1310110023#_2b48eb46_f5b7_45e3_a776_f7fa5f61f736
is: Q4G1C4
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:284273
boundary condition: true
type: Species
name: ZADH2
is: SBO:0000252

metaR SERDGLNexR
is described by: ECO:0000304
reactant: MODEL1310110023#
fast: false
kinetic law: MODEL1310110023#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110023#
is: SBO:0000185
name: D-Serine/Glutamine reversible exchange
modifier: MODEL1310110023#

metaR RDH3
reversible: true
is: SBO:0000176
reactant: MODEL1310110023#
name: retinol dehydrogenase (11-cis,NADH)
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368 NOTES:IT
product: MODEL1310110023#
fast: false
kinetic law: MODEL1310110023#
type: Reaction
modifier: MODEL1310110023#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.315

metaR PHEt4
notes: GENE_ASSOCIATION: (54407.1) or (84889.1) or (11254.1) or (6542.1) or (81539.1) or (6541.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
reactant: MODEL1310110023#
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
name: L-phenylalanine transport in via sodium symport
fast: false
reversible: false
is: SBO:0000185
type: Reaction
product: MODEL1310110023#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110023#_fc99e952_258d_4979_8e3d_e7b97fd0d36c
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4126
type: Species
constant: false
initial concentration: NaN
has only substance units: false
name: MANBA
is: O00462

http://identifiers.org/biomodels.db/MODEL1310110023#_78c43fce_da4f_4cd8_b69a_bdb2221cc950
type: Species
is encoded by: hsa:23533
initial concentration: NaN
name: PIK3R5:PIK3CG
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
has part: Q8WYR1
is: SBO:0000297

metaR r0381
is: SBO:0000176
reversible: true
product: MODEL1310110023#
kinetic law: MODEL1310110023#
is described by: ECO:0000000
name: hypotaurine:NAD+ oxidoreductase Taurine and hypotaurine metabolism EC:1.8.1.3
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.8.1.3 Confidence Level: 0 AUTHORS: PMID:13979247,PMID:16680556,PMID:7295801 NOTES:
fast: false
type: Reaction

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

metaR 5MTHFt2le
is described by: ECO:0000134
name: 5-methyltetrahydrofolate transport via anion exchange
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
kinetic law: MODEL1310110023#
type: Reaction
product: MODEL1310110023#
reactant: MODEL1310110023#
fast: false

metaM ipdp x
is: SBO:0000247
constant: false
boundary condition: false
type: Species
name: isopentenyl diphosphate(3-)
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
is: HMDB01347
has only substance units: false
initial concentration: 1.0
is: CHEBI:128769
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_46c5349c_292c_482f_9cc0_e23bada8bc3b
is encoded by: hsa:2821
constant: false
type: Species
initial amount: NaN
is: P06744
is: SBO:0000252
has only substance units: false
boundary condition: true
name: GPI
initial concentration: NaN

metaR LCADi D
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
reactant: MODEL1310110023#
reversible: false
product: MODEL1310110023#
is: SBO:0000176
modifier: MODEL1310110023#
name: lactaldehyde dehydrogenase
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.36
kinetic law: MODEL1310110023#
fast: false
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.2.1.5
is version of: http://identifiers.org/ec-code/1.2.1.3

metaM s2l2fn2m2masn l
notes: FORMULA: C90H145N6O65X CHARGE: -2
boundary condition: false
type: Species
name: PA6
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB00174
is: CHEBI:18287
has only substance units: false

metaR r1656
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
modifier: MODEL1310110023#
type: Reaction

metaR PPNCL3
type: Reaction
is described by: ECO:0000269
product: MODEL1310110023#
modifier: MODEL1310110023#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/6.3.2.5
notes: GENE_ASSOCIATION: (79717.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110023#
is: SBO:0000176
reactant: MODEL1310110023#
name: phosphopantothenate-cysteine ligase

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

metaR r2198
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
modifier: MODEL1310110023#
fast: false
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
type: Reaction
is described by: ECO:0000000
product: MODEL1310110023#
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#

metaM ptth m
name: pantetheine
is: SBO:0000247
boundary condition: false
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
is: HMDB03426
initial amount: NaN
is: CHEBI:16753

metaM ksi pre27 g
initial amount: NaN
has only substance units: false
is: HMDB00175
type: Species
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 27
notes: FORMULA: C205H328N14O171S8X CHARGE: -9
is: C00130
boundary condition: false
constant: false
is: CHEBI:58053

http://identifiers.org/biomodels.db/MODEL1310110023#_f1bf00cc_754f_412f_b1e7_efa5f3b1f96d
is encoded by: hsa:1962
is: Q9NY65
type: Species
name: EHHADH
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaM h c
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: H CHARGE: 1 INCHI: "
name: proton
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/3380
type: Species
is: C00080
is: CHEBI:24636

metaM hs deg19 l
is: CHEBI:17180
notes: FORMULA: C43H67N2O42S2 CHARGE: -3
is: HMDB01352
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
name: heparan sulfate, degradation product 19
initial concentration: 1.0
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110023#_36e2ff5c_2135_443f_8710_af2d96d5d5e9
initial amount: NaN
is encoded by: hsa:AA419122
initial concentration: NaN
boundary condition: true
name: _AA419122_1_c
type: Species
has only substance units: false
constant: false
is: SBO:0000252

metaR r1538
name: Anion Exchanger (AE) TCDB:2.A.31.2.8
is version of: http://identifiers.org/ec-code/1.17.4.1
type: Reaction
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
fast: false
product: MODEL1310110023#
kinetic law: MODEL1310110023#
reversible: false
is: SBO:0000185
reactant: MODEL1310110023#
is described by: ECO:0000000
modifier: MODEL1310110023#

metaR r1655
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110023#
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
kinetic law: MODEL1310110023#
type: Reaction
reversible: true
reactant: MODEL1310110023#
is described by: ECO:0000000

metaR ATPtm
is: SBO:0000185
kinetic law: MODEL1310110023#
reversible: false
is described by: ECO:0000269
product: MODEL1310110023#
reactant: MODEL1310110023#
name: ADP/ATP transporter, mitochondrial
modifier: MODEL1310110023#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (291.1) or (293.1) or (292.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD

metaR r2199
type: Reaction
reactant: MODEL1310110023#
is described by: ECO:0000000
kinetic law: MODEL1310110023#
fast: false
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
modifier: MODEL1310110023#
product: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_4553cc06_fee8_406f_ac6f_337f0b80ffe1
initial amount: NaN
is encoded by: hsa:9245
is: SBO:0000252
type: Species
has only substance units: false
is: O95395
name: GCNT3
constant: false
initial concentration: NaN
boundary condition: true

metaR DPPS
is described by: ECO:0000134
fast: false
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: Confidence Level: 2 AUTHORS: PMID:16262699 NOTES:by analogy to other dimethyl transferase rxns. See PMID: 10586494, human interemidate (from C15 ->C50) not explicitly determined yet, however it is known to occur since this pathway is essential in Q10 synthesis. For human metabolism: may be associated w/ GeneID: 23590 TPRT - recheck lit in future IT and NJ
type: Reaction
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
name: decaprenyl synthase
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110023#_db6c1357_ccf3_44d8_b711_146cbf9df7fe
is: SBO:0000252
is encoded by: hsa:341947
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is: Q7Z4L0
constant: false
name: COX8C

metaR r2318
reversible: true
kinetic law: MODEL1310110023#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110023#
product: MODEL1310110023#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
type: Reaction

metaR GGLUCT
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (79017.1) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.4 Confidence Level: 4 AUTHORS: PMID:2570694 NOTES:SAB
type: Reaction
product: MODEL1310110023#
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.3.2.4
name: gamma-glutamylcyclotransferase
is: SBO:0000185
is described by: ECO:0000269
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_5b6d30be_ca5b_4e29_ab29_4597ab6e8d33
initial concentration: NaN
constant: false
initial amount: NaN
is: Q6UWQ5
is: SBO:0000252
is encoded by: hsa:84569
name: LYZL1
has only substance units: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_43603290_7389_44fb_a3ab_6e3b2422cde3
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q99714
boundary condition: true
type: Species
initial concentration: NaN
name: HSD17B10
constant: false
is encoded by: hsa:3028

metaM succ x
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:30031
is: C00042
boundary condition: false
is: HMDB00254
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
constant: false
has only substance units: false
name: Succinate
is: SBO:0000247

metaR r1654
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110023#
is described by: ECO:0000000
fast: false
is: SBO:0000185
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
reactant: MODEL1310110023#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM pmtcoa m
boundary condition: false
is: SBO:0000247
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
initial amount: NaN
is: C00154
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
is: HMDB01338
is: CHEBI:57379
name: Palmitoyl-CoA (n-C16:0CoA)

metaM h e
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: H CHARGE: 1 INCHI: "
name: proton
is: http://identifiers.org/pubchem.compound/3380
initial concentration: 1.0
type: Species
is: C00080
boundary condition: false
is: SBO:0000247
is: CHEBI:24636

metaM lac L e
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
type: Species
boundary condition: false
has only substance units: false
is: HMDB00190
is: CHEBI:16651
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: (S)-lactate
constant: false

metaR r2196
modifier: MODEL1310110023#
reactant: MODEL1310110023#
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110023#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaR r0384
is: SBO:0000176
fast: false
reversible: false
name: 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
type: Reaction
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#

metaM 3pg m
type: Species
initial concentration: 1.0
is: HMDB00807
is: SBO:0000247
is: CHEBI:58272
initial amount: NaN
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
constant: false
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_95bf6c29_2102_48a3_b933_fd87d895a30b
type: Species
is: SBO:0000252
name: OGDHL
boundary condition: true
initial amount: NaN
is: Q9ULD0
is encoded by: hsa:55753
initial concentration: NaN
constant: false
has only substance units: false

metaR r0055
kinetic law: MODEL1310110023#
fast: false
is described by: ECO:0000000
reversible: true
product: MODEL1310110023#
reactant: MODEL1310110023#
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.4.2.7
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.8
is: SBO:0000176
notes: GENE_ASSOCIATION: (353.1) or (3251.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 0 AUTHORS: PMID:20958,PMID:4383524,PMID:4391087,PMID:6014,PMID:7107625,PMID:7107626,PMID:7144586,PMID:7763257,PMID:7993370 NOTES:IT added 2 protons (are there really 2 protons produced?)
name: 2-Oxopropanal:NADP+ oxidoreductase Pyruvate metabolism EC:1.2.1.49

metaR AG13T5g
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110023#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reactant: MODEL1310110023#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_d4c5b428_1abc_407c_ab3c_9b64e107b505
has only substance units: false
initial concentration: NaN
name: ALG3
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:10195
constant: false
boundary condition: true

metaR DOPAt4 2 r
modifier: MODEL1310110023#
product: MODEL1310110023#
reversible: true
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is described by: ECO:0000269
reactant: MODEL1310110023#
fast: false
kinetic law: MODEL1310110023#
name: Dopamine reversible transport in via sodium symport (1:2)
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110023#_eba1f5d3_11a1_46af_8cc9_c8c59fa55067
is: B7Z6M3
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8525
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
name: DGKZ

metaR DCK1n
type: Reaction
product: MODEL1310110023#
reactant: MODEL1310110023#
fast: false
name: Deoxycytidine kinase, nuclear (ATP)
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.1.74
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110023#
is: SBO:0000176

metaR r2319
kinetic law: MODEL1310110023#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110023#
product: MODEL1310110023#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true

metaR r0385
is: SBO:0000176
fast: false
product: MODEL1310110023#
is described by: ECO:0000000
reactant: MODEL1310110023#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
kinetic law: MODEL1310110023#
type: Reaction
name: 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4

http://identifiers.org/biomodels.db/MODEL1310110023#_127e7014_d3b4_42ca_9ac4_ef2871e86ee2
is: O95479
has only substance units: false
initial amount: NaN
name: H6PD
initial concentration: NaN
is encoded by: hsa:9563
is: SBO:0000252
constant: false
boundary condition: true
type: Species

metaR r1653
fast: false
type: Reaction
reactant: MODEL1310110023#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110023#

metaM ru5p D c
is: CHEBI:58121
has only substance units: false
name: D-ribulose 5-phosphate(2-)
is: HMDB00618
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_e9a27c96_aec8_45b9_8d76_e8b8274b6fa6
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: PYCR2
is: Q96C36
is encoded by: hsa:29920
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_9071914d_9b84_4987_8930_890dae9f3b05
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: COQ6
is: Q9Y2Z9
constant: false
is encoded by: hsa:51004
type: Species
initial amount: NaN
has only substance units: false

metaR r2197
kinetic law: MODEL1310110023#
type: Reaction
reactant: MODEL1310110023#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
modifier: MODEL1310110023#
reversible: true
product: MODEL1310110023#

metaR TMDS
fast: false
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (7298.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.1.1.45 Confidence Level: 4 AUTHORS: PMID:14967037,PMID:2243092 NOTES:
is version of: http://identifiers.org/ec-code/2.1.1.45
product: MODEL1310110023#
reversible: false
kinetic law: MODEL1310110023#
name: thymidylate synthase
reactant: MODEL1310110023#
type: Reaction

metaM dhlam m
is: HMDB00985
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
is: CHEBI:17694
name: dihydrolipoamide
is: SBO:0000247
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
boundary condition: false

metaM atp x
type: Species
name: ATP(4-)
is: C00002
is: HMDB00538
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:57299
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_ef2f3be3_a489_4310_8e19_d62041cdbef7
initial amount: NaN
is: O60701
is encoded by: hsa:7358
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: UGDH
boundary condition: true
constant: false

metaR GALt1r
product: MODEL1310110023#
kinetic law: MODEL1310110023#
is: SBO:0000185
name: galactose transport (uniport)
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (29988.1) or (6513.1) or (6515.1) or (6514.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860996,PMID:11247674,PMID:11592815,PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:NCD
is described by: ECO:0000269
reactant: MODEL1310110023#
fast: false
type: Reaction
reversible: true

metaM txa2 r
type: Species
is: CHEBI:57445
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
name: thromboxane A2(1-)
has only substance units: false
is: HMDB01452
initial amount: NaN

metaR r0166
type: Reaction
reversible: false
name: Uridine triphosphate pyrophosphohydrolase Pyrimidine metabolism EC:3.6.1.19
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reactant: MODEL1310110023#
product: MODEL1310110023#
fast: false
kinetic law: MODEL1310110023#
is described by: ECO:0000000

metaR OCDCAtr
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
product: MODEL1310110023#
type: Reaction
name: fatty acid transport via diffusion
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110023#_ff14a733_2d36_4772_9c45_69472d8c2317
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:1545
boundary condition: true
name: CYP1B1
initial amount: NaN
is: Q16678
is: SBO:0000252

metaR DURIPP
reversible: true
is described by: ECO:0000269
fast: false
modifier: MODEL1310110023#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.1
kinetic law: MODEL1310110023#
name: deoxyuridine phosphorylase
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
is version of: http://identifiers.org/ec-code/2.4.2.3
product: MODEL1310110023#
is: SBO:0000176

metaM dgtp e
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
name: dGTP
is: CHEBI:16497
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB01440

metaR DAGK hs
is described by: ECO:0000269
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.1.107
name: Diacylglycerol phosphate kinase (homo sapiens)
product: MODEL1310110023#
fast: false
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
type: Reaction

metaR FAOXC14C12m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_6ab470c9_dc9a_44a3_bbd8_65f0213b7720
boundary condition: true
has only substance units: false
name: FLAD1
initial amount: NaN
type: Species
is: Q8NFF5
is: SBO:0000252
is encoded by: hsa:80308
constant: false
initial concentration: NaN

metaR r0688
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: true
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
kinetic law: MODEL1310110023#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110023#
is: SBO:0000176
modifier: MODEL1310110023#
product: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:

metaR r2195
fast: false
reversible: true
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110023#
is described by: ECO:0000000
product: MODEL1310110023#
is: SBO:0000185
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110023#

metaR DOLPMT1 Uer
reversible: false
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
is: SBO:0000176
product: MODEL1310110023#
kinetic law: MODEL1310110023#
fast: false
type: Reaction
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.4.1.258
notes: GENE_ASSOCIATION: (10195.4) or (10195.1) or (10195.3) or (10195.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110023#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110023#_b4e1c94d_a2e6_4bde_803d_f2755b90ae1f
constant: false
is: SBO:0000252
initial amount: NaN
name: ACSL1
type: Species
is: P33121
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2180

metaR RE3218C
reversible: true
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.1.6.2
is: SBO:0000176
modifier: MODEL1310110023#
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
name: RE3218
is described by: ECO:0000000

metaM CE2422 m
boundary condition: false
is: CHEBI:28387
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
initial concentration: 1.0
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA
constant: false
has only substance units: false
is: HMDB11123

metaR BHBt
type: Reaction
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
is described by: ECO:0000000
kinetic law: MODEL1310110023#
product: MODEL1310110023#
fast: false
reversible: true
is: SBO:0000185
name: (R)-3-Hydroxybutanoate transport via H+ symport

metaM atp r
is: CHEBI:57299
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
name: ATP(4-)
is: SBO:0000247
has only substance units: false
is: C00002
boundary condition: false
is: HMDB00538

metaM crn e
initial concentration: 1.0
is: HMDB00062
constant: false
is: CHEBI:16347
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
has only substance units: false
boundary condition: false
is: C00318
name: L-Carnitine

metaR RE0915E
type: Reaction
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is: SBO:0000176
fast: false
modifier: MODEL1310110023#
reactant: MODEL1310110023#
product: MODEL1310110023#
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.2.1.1
is version of: http://identifiers.org/ec-code/3.2.1.17
reversible: true
is described by: ECO:0000000
name: RE0915

http://identifiers.org/biomodels.db/MODEL1310110023#_5bf7971d_3e76_45bf_90cd_8d430fc56f51
boundary condition: true
constant: false
initial amount: NaN
is: P09622
type: Species
name: DLD
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1738
has only substance units: false

metaR EX HC01361 LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Dihydroneopterin
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_1d17d820_6bd8_4d4d_a323_0550772b8998
type: Species
is encoded by: hsa:112724
has only substance units: false
is: B3KVA3
constant: false
initial concentration: NaN
name: RDH13
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR r1429
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: Free diffusion
product: MODEL1310110023#
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
reversible: true

metaR GALASE19ly
is: SBO:0000176
is described by: ECO:0000269
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110023#
reversible: false
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaR RE2973C
is version of: http://identifiers.org/ec-code/2.7.1.137
is version of: http://identifiers.org/ec-code/2.7.1.154
notes: GENE_ASSOCIATION: (5290.1) or (5291.1) or (5294.1) or (5289.1) or (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:
product: MODEL1310110023#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.153
reactant: MODEL1310110023#
name: RE2973
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.11.1
type: Reaction
fast: false
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110023#_2f44791f_0fae_446a_acaf_a3c5e39af758
type: Species
is encoded by: hsa:4522
name: MTHFD1
initial amount: NaN
is: P11586
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_05afecba_affe_4a21_9252_392965a66338
is: B3KQV3
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:79837
name: PIP4K2C

metaR r0388
name: Pyridoxamine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.4.3.5
is described by: ECO:0000000
product: MODEL1310110023#
kinetic law: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:
type: Reaction
reactant: MODEL1310110023#
reversible: true
is: SBO:0000176

metaR r1090
type: Reaction
name: TCDB:2.A.47.1.9 TCDB:2.A.29.7.2
product: MODEL1310110023#
reversible: false
fast: false
reactant: MODEL1310110023#
is: SBO:0000185
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000

metaR AHEXASE2ly
reversible: false
modifier: MODEL1310110023#
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
type: Reaction
is described by: ECO:0000000
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
is: SBO:0000176

metaR ACOAD9m
modifier: MODEL1310110023#
type: Reaction
product: MODEL1310110023#
name: acyl-CoA dehydrogenase (isobutyryl-CoA), mitochondrial
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (34.1) or (27034.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
reactant: MODEL1310110023#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110023#
reversible: false

metaR AHCYStr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ
name: S-Adenosyl-L-homocysteine intracellular diffusion
is: SBO:0000185
reactant: MODEL1310110023#
reversible: true
product: MODEL1310110023#
is described by: ECO:0000000
kinetic law: MODEL1310110023#
type: Reaction
fast: false

metaR RE0691C
fast: false
name: RE0691
reactant: MODEL1310110023#
reversible: true
is described by: ECO:0000000
product: MODEL1310110023#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
type: Reaction
kinetic law: MODEL1310110023#

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

metaR r1428
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reversible: true
name: Free diffusion
reactant: MODEL1310110023#
is described by: ECO:0000000

metaM HC01415 m
has only substance units: false
is: SBO:0000247
is: CHEBI:27537
constant: false
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276
type: Species
name: (2E)-Octenoyl-CoA
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaM dgtp c
is: HMDB01440
initial concentration: 1.0
is: C00286
type: Species
name: dGTP
initial amount: NaN
is: CHEBI:16497
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286

metaR r0686
reversible: true
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.2.2
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
reactant: MODEL1310110023#
is: SBO:0000176
product: MODEL1310110023#
fast: false

metaR r2193
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
type: Reaction
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000000
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185

metaM cdp n
initial concentration: 1.0
name: CDP(3-)
is: SBO:0000247
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: CHEBI:58069
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: HMDB01546
boundary condition: false

metaR r0276
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.1.1.21
is: SBO:0000176
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.1.1.2
name: NADH:guanosine-5-phosphate oxidoreductase(deaminating) Purine metabolism EC:1.7.1.7
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (10327.1) or (231.1) SUBSYSTEM: Purine catabolism EC Number: 1.7.1.7 Confidence Level: 0 AUTHORS: PMID:12009299,PMID:12669231 NOTES:
product: MODEL1310110023#
reversible: true
type: Reaction
reactant: MODEL1310110023#

metaR GLYCTDle
product: MODEL1310110023#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: difussion of glycerol accross the brush border membrane
reactant: MODEL1310110023#
fast: false
is described by: ECO:0000134

metaR r0389
is: SBO:0000176
kinetic law: MODEL1310110023#
is described by: ECO:0000000
type: Reaction
reversible: true
product: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.1.3.12 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:
fast: false
name: Pyridoxine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.1.3.12

http://identifiers.org/biomodels.db/MODEL1310110023#_c00c86ec_b8f1_40bf_a027_226ec0f30794
constant: false
is encoded by: hsa:6392
has part: P21912
is encoded by: hsa:6391
name: SDHA:SDHB:SDHC:SDHD
type: Species
boundary condition: true
is encoded by: hsa:6389
has part: O14521
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:6390
is: SBO:0000297
has part: P31040
has part: Q99643

metaR r1427
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
is: SBO:0000185
kinetic law: MODEL1310110023#
product: MODEL1310110023#
is described by: ECO:0000000
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
type: Reaction
reversible: false

metaM pmtcoa r
is: SBO:0000247
is: CHEBI:3454
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
constant: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
is: HMDB01338
is: C00154
name: Palmitoyl-CoA (n-C16:0CoA)
initial concentration: 1.0

metaM 2dp6mep m
initial amount: NaN
has only substance units: false
is: CHEBI:50774
notes: FORMULA: C57H88O2 CHARGE: 0 INCHI: InChI=1S/C57H88O2/c1-45(2)23-13-24-46(3)25-14-26-47(4)27-15-28-48(5)29-16-30-49(6)31-17-32-50(7)33-18-34-51(8)35-19-36-52(9)37-20-38-53(10)39-21-40-54(11)43-44-55-41-22-42-56(59-12)57(55)58/h22-23,25,27,29,31,33,35,37,39,41-43,58H,13-21,24,26,28,30,32,34,36,38,40,44H2,1-12H3/b46-25+,47-27+,48-29+,49-31+,50-33+,51-35+,52-37+,53-39+,54-43+
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
name: 2-Decaprenyl-6-methoxyphenol
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_1610d44e_46e6_4f6c_a7ba_eb6e2ac20b84
has only substance units: false
initial amount: NaN
has part: O15254
is encoded by: hsa:3295
boundary condition: true
type: Species
has part: E9PB82
has part: Q96CA6
is encoded by: hsa:8310
has part: Q9NY65
is encoded by: hsa:30
is: SBO:0000297
initial concentration: NaN
is encoded by: hsa:1962
constant: false
name: EHHADH:ACAA1:HSD17B4:ACOX3

http://identifiers.org/biomodels.db/MODEL1310110023#_e2c783b6_ad2d_4860_a8b5_c5c45919f1b7
type: Species
is encoded by: hsa:4731
name: NDUFV3
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM atp m
is: CHEBI:57299
has only substance units: false
constant: false
is: C00002
name: ATP(4-)
is: HMDB00538
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0

metaM galgbside hs g
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:18259
notes: FORMULA: C50H89N2O27FULLRCO CHARGE: 0
has only substance units: false
initial amount: NaN
type: Species
name: galactosylgloboside
constant: false
boundary condition: false

metaM m5masnC g
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: HMDB00968
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial concentration: 1.0
notes: FORMULA: C52H87N2O40X CHARGE: 0
is: SBO:0000247
is: CHEBI:58282

metaM 5oxpro c
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00856 EHMN_ABBREVIATION: C01879
is: CHEBI:57606
initial concentration: 1.0
is: HMDB00267
name: 5-oxoprolinate
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110023#_e7c3414f_f016_4538_8050_8f99942565c4
name: CA6
is: Q5FC00
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:765
boundary condition: true
initial amount: NaN
has only substance units: false

metaR MALTt1r
modifier: MODEL1310110023#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
is: SBO:0000185
name: maltose transport (uniport)
product: MODEL1310110023#
kinetic law: MODEL1310110023#
type: Reaction
fast: false
reactant: MODEL1310110023#
reversible: true

metaR CERT1rt
reversible: true
name: ceramide transport protein
fast: false
reactant: MODEL1310110023#
is: SBO:0000185
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
is described by: ECO:0000304
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.11.1
modifier: MODEL1310110023#
type: Reaction
product: MODEL1310110023#

metaM atp n
constant: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
initial concentration: 1.0
name: ATP(3-)
is: HMDB00538
is: SBO:0000247
is: CHEBI:57299
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110023#_ec2e5218_4c79_4d86_b52b_58ba16094613
type: Species
has only substance units: false
is: Q16718
boundary condition: true
is: SBO:0000252
name: NDUFA5
is encoded by: hsa:4698
initial amount: NaN
initial concentration: NaN
constant: false

metaR TRPHYDRO2
reversible: false
product: MODEL1310110023#
is described by: ECO:0000269
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (7166.1) or (121278.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.16.4 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:12379098 NOTES:SAB unlumped version of TRPHYDRO1
type: Reaction
is: SBO:0000176
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
fast: false
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.14.16.4

http://identifiers.org/biomodels.db/MODEL1310110023#_819c127f_a3a4_4504_8cfd_ca8641bbfa15
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: GGT1
constant: false
is encoded by: hsa:2678
type: Species
is: SBO:0000252

metaR DHFtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
type: Reaction
product: MODEL1310110023#
reversible: true
name: dihydrofolate reversible mitochondrial transport
is: SBO:0000185
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
fast: false
is described by: ECO:0000000

metaR RE1691M
reversible: true
name: RE1691
type: Reaction
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
reactant: MODEL1310110023#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.8.1.1
fast: false
notes: GENE_ASSOCIATION: (7263.1) SUBSYSTEM: Miscellaneous EC Number: 2.8.1.1 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:9070219 NOTES:
product: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_b5d8027b_99c7_4682_8e35_dcf9927ddbd0
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:8869
is: Q9UNP4
initial concentration: NaN
type: Species
name: ST3GAL5
has only substance units: false

metaR FAOXC184x
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:4)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_08ad907e_1769_4c57_bc24_8ef42fcb4d04
constant: false
boundary condition: true
type: Species
is: P23634
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:493
name: ATP2B4

metaR 3SALATAim
is: SBO:0000176
reactant: MODEL1310110023#
is described by: ECO:0000304
type: Reaction
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM. activity measured in rat, 3-sulfinoalanine is substrate found in human brain
is version of: http://identifiers.org/ec-code/2.6.1.1
modifier: MODEL1310110023#
name: 3-sulfino-alanine transaminase (irreversible), mitochondrial
fast: false
kinetic law: MODEL1310110023#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110023#_cd555b2a_49b6_4003_985c_fb4efe1d0dbe
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4357
constant: false
boundary condition: true
name: MPST
initial amount: NaN
type: Species
is: SBO:0000252
is: P25325

metaR HSPGtly
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
fast: false
reversible: false
name: heparan sulfate transport, extracellular to lysosome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#

metaR LNLNCGt
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110023#
type: Reaction
product: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110023#
reversible: true
name: fatty acid transport via diffusion

metaR G14T17g
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
reactant: MODEL1310110023#
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.4.1.38
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reversible: false

metaR r0160
kinetic law: MODEL1310110023#
type: Reaction
name: L-Serine:pyruvate aminotransferase Glycine, serine and threonine metabolism EC:2.6.1.51
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.51 Confidence Level: 0 AUTHORS: PMID:10347152,PMID:6469715 NOTES:
is: SBO:0000176
modifier: MODEL1310110023#
fast: false
reactant: MODEL1310110023#
reversible: false
is version of: http://identifiers.org/ec-code/2.1.3.2
product: MODEL1310110023#
is described by: ECO:0000000

metaR MI145PP
is version of: http://identifiers.org/ec-code/3.1.3.36
is version of: http://identifiers.org/ec-code/3.1.3.86
type: Reaction
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
modifier: MODEL1310110023#
is: SBO:0000176
reversible: false
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.56
reactant: MODEL1310110023#
name: inositol-1,4,5-trisphosphate 5-phosphatase
product: MODEL1310110023#

metaM ddcacoa m
is: CHEBI:57375
initial concentration: 1.0
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
has only substance units: false
type: Species
is: HMDB03571
is: C01832
constant: false
is: SBO:0000247
initial amount: NaN
name: Dodecanoyl-CoA (n-C12:0CoA)
boundary condition: false

metaM ppp9 m
notes: FORMULA: C34H32N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00905 EHMN_ABBREVIATION: C02191
is: HMDB00241
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: Protoporphyrin
constant: false
is: CHEBI:36159
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_a7e4a620_42e2_48ac_97b7_6270e1b6fa5f
is: SBO:0000252
name: PRDX1
initial amount: NaN
boundary condition: true
is encoded by: hsa:5052
initial concentration: NaN
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_8550fb95_21df_410e_9a93_9d26b4fc9272
constant: false
is: Q92185
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6489
name: ST8SIA1

http://identifiers.org/biomodels.db/MODEL1310110023#_a177d5e3_4baa_486c_abf1_87ad18474d12
is encoded by: hsa:AW277253
constant: false
name: _AW277253_1_c
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_8f60860e_9556_4f16_9d69_c88f1bbed061
initial amount: NaN
is encoded by: hsa:131
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: P40394
name: ADH7
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_6711bd20_9f93_4e18_a814_1df3f5c77e4c
is encoded by: hsa:5805
boundary condition: true
initial concentration: NaN
type: Species
name: PTS
is: Q03393
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252

metaR HDCAtr
fast: false
reactant: MODEL1310110023#
type: Reaction
name: fatty acid transport via diffusion
kinetic law: MODEL1310110023#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000185

metaR FAOXC226205m
is described by: ECO:0000000
reversible: false
type: Reaction
name: Beta oxidation of long chain fatty acid
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:_1 round of beta-oxidation, loses degree of desat, so no fad peroxisomal (very long chain FA) c22:6,n-3 -> c20:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110023#
is: SBO:0000176

metaR SUCCtp
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
type: Reaction
name: succinate transporter, peroxisome
fast: false
reversible: true
kinetic law: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110023#

metaR TDPm
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: 3.6.1.15 Confidence Level: 2 AUTHORS: PMID:9755848 NOTES:_01-25-05 IT
product: MODEL1310110023#
kinetic law: MODEL1310110023#
fast: false
name: thiamin pyrophosphatase, mitochondrial
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110023#_64887ef7_e1c4_44cf_89fc_b319b2fb171d
has part: A7E2E0
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:8503
type: Species
has only substance units: false
has part: Q92569
name: PIK3CD:PIK3R3
is encoded by: hsa:5293

metaR FUT33g
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.65
reactant: MODEL1310110023#
modifier: MODEL1310110023#
is described by: ECO:0000269
is: SBO:0000176
name: fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group included) 1
product: MODEL1310110023#
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (2525.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.65 Confidence Level: 4 AUTHORS: PMID:12424536,PMID:12493760,PMID:1977660 NOTES:NJ
reversible: false
type: Reaction

metaM CE2705 c
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
name: quinonoid dihydrobiopterin
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:36781

metaM gbside hs g
has only substance units: false
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
name: globoside
initial concentration: 1.0
is: CHEBI:18259
boundary condition: false
constant: false
is: SBO:0000247
type: Species
initial amount: NaN

metaR r2044
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
product: MODEL1310110023#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110023#

metaM CE2435 m
is: CHEBI:57795
name: trans,cis-deca-2,4-dienoyl-CoA
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
is: SBO:0000247
constant: false
has only substance units: false
type: Species

metaR ACt2m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true
name: acetate mitochondrial transport via proton symport
fast: false
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD

metaR r1766
is described by: ECO:0000000
reversible: false
fast: false
kinetic law: MODEL1310110023#
product: MODEL1310110023#
modifier: MODEL1310110023#
is: SBO:0000185
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110023#
type: Reaction

metaM crn c
is: C00318
is: CHEBI:16347
constant: false
is: HMDB00062
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
name: L-Carnitine
initial concentration: 1.0
initial amount: NaN

metaR UPPN
kinetic law: MODEL1310110023#
is described by: ECO:0000269
name: b-ureidopropionase
reactant: MODEL1310110023#
is: SBO:0000176
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.5.1.6
type: Reaction
reversible: false
product: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:10542323,PMID:12450676 NOTES:SAB balanced

http://identifiers.org/biomodels.db/MODEL1310110023#_135aecdb_5872_4dfb_838e_3dcda002fb25
is: Q6FG42
name: NDUFA7
initial amount: NaN
is encoded by: hsa:4701
type: Species
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaM dcsptn1coa c
constant: false
is: http://identifiers.org/pubchem.compound/47205483
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
is: HMDB06513
type: Species
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: C16173
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110023#_d24fe930_55ba_4cb4_82fc_8065ce70304f
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AA081045
constant: false
name: _AA081045_1_c
boundary condition: true
type: Species
is: SBO:0000252

metaR DM dttp n
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dttp(n)
type: Reaction

metaR G14T18g
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110023#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
modifier: MODEL1310110023#
is: SBO:0000176
kinetic law: MODEL1310110023#
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false

metaM taur c
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
boundary condition: false
name: Taurine
initial amount: NaN
is: HMDB00251
has only substance units: false
notes: FORMULA: C2H7NO3S CHARGE: 0
is: C00245
is: CHEBI:3544

metaR LSTO1r
is described by: ECO:0000269
reactant: MODEL1310110023#
modifier: MODEL1310110023#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
name: Lathosterol oxidase
type: Reaction
reversible: false
kinetic law: MODEL1310110023#
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.14.21.6
fast: false

metaR r0595
product: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 2.8.1.2 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:851908 NOTES:
name: 3-Mercaptopyruvate:cyanide sulfurtransferase Cysteine metabolism EC:2.8.1.2
type: Reaction
is described by: ECO:0000000
reversible: false
is: SBO:0000176
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_7ed80e1b_1b11_4e54_afee_4439d64fb5e1
has only substance units: false
is: E9KL42
initial concentration: NaN
constant: false
is encoded by: hsa:641371
name: ACOT1
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_f21cfbe9_1fe5_4680_98aa_5bd69c17fe73
is: Q6FH11
type: Species
has only substance units: false
is encoded by: hsa:3162
initial concentration: NaN
initial amount: NaN
name: HMOX1
constant: false
is: SBO:0000252
boundary condition: true

metaM g1m8mpdol U r
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:59093
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C1785H2940N20O670P20 CHARGE: -20
type: Species

metaM succ c
has only substance units: false
constant: false
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
name: Succinate
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB00254
is: C00042
type: Species
is: CHEBI:30031
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110023#_f917c325_d3c9_4a8d_86a0_da9c99fb12b6
initial concentration: NaN
is: F8WDN9
initial amount: NaN
constant: false
is encoded by: hsa:27068
name: PPA2
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species

metaR PI45P4P
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
is described by: ECO:0000000
reversible: false
name: phosphatidylinositol-4,5-bisphosphate 4-phosphatase
is: SBO:0000176
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
type: Reaction
product: MODEL1310110023#
fast: false

metaR r0594
type: Reaction
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
modifier: MODEL1310110023#
reversible: true
kinetic law: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false

metaR EX tag hs LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: triacylglycerol (homo sapiens) exchange
type: Reaction

metaM n2m2mn l
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C42H71N3O31 CHARGE: 0
type: Species
boundary condition: false
is: CHEBI:16680
is: HMDB00939
name: de-Fuc, reducing GlcNAc removed, de-Sia, de-Gal form of PA6 (w/o peptide linkage)
is: SBO:0000247

metaR AIRCr
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/6.3.2.6
modifier: MODEL1310110023#
type: Reaction
name: phosphoribosylaminoimidazole carboxylase
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
is: SBO:0000176
fast: false
kinetic law: MODEL1310110023#
is described by: ECO:0000269
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_bf1fe9eb_c302_4fdb_a22e_b703025e32b3
constant: false
is: P17752
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: TPH1
is: SBO:0000252
has only substance units: false
is encoded by: hsa:7166

metaR FAOXC163x
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_b2d1a66e_7390_441c_83ac_be49c360c179
is: Q16647
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
name: PTGIS
has only substance units: false
type: Species
is encoded by: hsa:5740

metaR r0480
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110023#
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
product: MODEL1310110023#
fast: false
reactant: MODEL1310110023#
type: Reaction
reversible: true

metaR UAGDP
fast: false
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
product: MODEL1310110023#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.23
name: UDP-N-acetylglucosamine diphosphorylase
modifier: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_ac810390_6907_4264_82ba_a4c62ec25ded
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: O00624
name: SLC17A2
initial amount: NaN
constant: false
is encoded by: hsa:10246

http://identifiers.org/biomodels.db/MODEL1310110023#_3d558a67_0d42_4e08_ba35_d0061b9d892e
is encoded by: hsa:54675
constant: false
is: Q9UJA2
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: CRLS1
has only substance units: false
type: Species

metaR r2321
is described by: ECO:0000000
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
fast: false
product: MODEL1310110023#

metaR r1433
type: Reaction
fast: false
reversible: false
product: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
reactant: MODEL1310110023#
name: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9
kinetic law: MODEL1310110023#

metaR EX thr L LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Threonine exchange
type: Reaction

metaM udpglcur c
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
is: CHEBI:58052
is: C00167
is: SBO:0000247
has only substance units: false
is: HMDB00935
name: UDP-D-glucuronate
initial amount: NaN
boundary condition: false

metaR NDPK4n
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is described by: ECO:0000304
type: Reaction
kinetic law: MODEL1310110023#
is: SBO:0000176
reactant: MODEL1310110023#
name: nucleoside-diphosphate kinase (ATP:dTDP), nuclear
fast: false
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110023#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110023#_f7002b25_5752_43a2_b52e_0b3ff1bd38ba
is encoded by: hsa:2645
type: Species
constant: false
initial concentration: NaN
boundary condition: true
name: GCK
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaR DHCRD1
name: dihydroceramide desaturase
is: SBO:0000176
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
kinetic law: MODEL1310110023#
type: Reaction
product: MODEL1310110023#
is described by: ECO:0000269
modifier: MODEL1310110023#
fast: false
reactant: MODEL1310110023#
reversible: false

metaR r1434
reactant: MODEL1310110023#
fast: false
is described by: ECO:0000000
product: MODEL1310110023#
reversible: false
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
type: Reaction
name: Transport reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_cf271b09_4e6d_41e6_930a_4036e7e2d8df
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:3295
name: HSD17B4
is: SBO:0000252
is: E9PB82
has only substance units: false
constant: false

metaM fucgalacglcgalgluside hs g
notes: FORMULA: C50H89N2O26FULLRCO CHARGE: 0
initial concentration: 1.0
name: Type IH glycolipid
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:17158
boundary condition: false
is: HMDB01167
type: Species
initial amount: NaN

metaM orot5p c
name: Orotidine 5'-phosphate
notes: FORMULA: C10H10N2O11P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00669 EHMN_ABBREVIATION: C01103
is: CHEBI:57538
boundary condition: false
is: HMDB00218
is: C01103
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN

metaM 3odcoa m
is: SBO:0000247
name: 3-Oxodecanoyl-CoA
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
initial concentration: 1.0
is: CHEBI:28528
constant: false
type: Species
is: HMDB03939
initial amount: NaN
boundary condition: false
has only substance units: false

metaR GASNASE3ly
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.5.1.26 Confidence Level: 4 AUTHORS: PMID:1703489,PMID:2401370,PMID:8002961 NOTES:NCD
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.5.1.26
is described by: ECO:0000000
reversible: false
fast: false
name: glycosylasparaginase, lysosomal
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
type: Reaction
is: SBO:0000176

metaR PMTCOAtx
fast: false
product: MODEL1310110023#
kinetic law: MODEL1310110023#
name: fatty acid intracellular transport
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is described by: ECO:0000000
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_ed0c023b_0c50_4535_bb72_452c4678a546
has only substance units: false
is encoded by: hsa:6799
name: SULT1A2
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is: P50226
is: SBO:0000252

metaR biomass reaction
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110023#
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
fast: false
reversible: false
name: Generic human biomass reaction
kinetic law: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_717a6cf8_a263_4164_9e3a_a56372638912
type: Species
initial amount: NaN
is: Q9HAS3
is: SBO:0000252
is encoded by: hsa:64078
constant: false
has only substance units: false
name: SLC28A3
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_b1e8c9ba_5146_4851_a188_092f8fae1e3a
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:58510
has only substance units: false
name: PRODH2
is: Q9UF12

metaM pmtcoa x
constant: false
name: Palmitoyl-CoA (n-C16:0CoA)
initial concentration: 1.0
boundary condition: false
is: C00154
initial amount: NaN
is: CHEBI:57379
has only substance units: false
type: Species
is: HMDB01338
is: SBO:0000247
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154

metaR GARFT
reactant: MODEL1310110023#
is: SBO:0000176
modifier: MODEL1310110023#
reversible: true
product: MODEL1310110023#
kinetic law: MODEL1310110023#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.2.2
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.2 Confidence Level: 4 AUTHORS: PMID:12450384,PMID:2183217,PMID:9328467,PMID:9473452 NOTES:
name: phosphoribosylglycinamide formyltransferase
is described by: ECO:0000269

metaM fucacgalfucgalacglcgalgluside hs g
is: C00445
name: (Gal)2 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)2 (Cer)1
is: SBO:0000247
is: CHEBI:57455
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01354
notes: FORMULA: C64H112N3O35FULLRCO CHARGE: 0
type: Species
constant: false

metaR r2320
reversible: true
type: Reaction
product: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110023#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_0d57a561_f80f_4ee6_88da_52330516c9f0
is encoded by: hsa:81031
type: Species
is: SBO:0000252
has only substance units: false
constant: false
name: SLC2A10
boundary condition: true
is: O95528
initial amount: NaN
initial concentration: NaN

metaM dad 2 c
constant: false
is: CHEBI:17256
type: Species
is: HMDB00101
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
initial concentration: 1.0
name: 2-deoxyadenosine
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaM gchola x
is: SBO:0000247
notes: FORMULA: C26H43NO6 CHARGE: 0 INCHI: InChI=1S/C26H43NO6/c1-14(4-7-22(31)27-13-23(32)33)17-5-6-18-24-19(12-21(30)26(17,18)3)25(2)9-8-16(28)10-15(25)11-20(24)29/h14-21,24,28-30H,4-13H2,1-3H3,(H,27,31)(H,32,33)/p-1/t14-,15+,16-,17-,18+,19+,20-,21+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
boundary condition: false
initial amount: NaN
constant: false
name: glycocholate
is: CHEBI:58235
has only substance units: false
type: Species
is: HMDB00138
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110023#_5fa4e6d6_4e7e_4d36_bb31_a03da918c388
type: Species
boundary condition: true
is: P21439
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
name: ABCB4
is encoded by: hsa:5244
is: SBO:0000252

metaM cs e deg5 l
constant: false
has only substance units: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 5
boundary condition: false
is: HMDB00868
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C31H47NO35S3 CHARGE: -4
is: CHEBI:57737
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_d33570e7_e995_464e_8f9d_c0084b12fe9d
is: SBO:0000252
boundary condition: true
name: MLYCD
has only substance units: false
type: Species
is: O95822
constant: false
initial concentration: NaN
is encoded by: hsa:23417
initial amount: NaN

metaR PDX5PO
modifier: MODEL1310110023#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110023#
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.5
kinetic law: MODEL1310110023#
product: MODEL1310110023#
name: pyridoxine 5'-phosphate oxidase
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:15182361,PMID:6380540 NOTES:NCD
reversible: true
is: SBO:0000176

metaM fucacgalfucgalacglcgalgluside hs e
is: HMDB00660
name: (Gal)2 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)2 (Cer)1
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
has only substance units: false
notes: FORMULA: C64H112N3O35FULLRCO CHARGE: 0
is: C00095
is: SBO:0000247
initial amount: NaN
is: CHEBI:15824

metaR AMETtd
fast: false
type: Reaction
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: diffusion of S-Adenosyl-L-methionine
product: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000185
reversible: true
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_ea86805a_7d72_4ee4_a72f_664ca545657b
initial concentration: NaN
is encoded by: hsa:6470
is: SBO:0000252
constant: false
has only substance units: false
name: SHMT1
boundary condition: true
initial amount: NaN
type: Species

metaM ksi deg5 l
boundary condition: false
has only substance units: false
is: HMDB00143
type: Species
name: keratan sulfate I, degradation product 5
is: CHEBI:12936
initial amount: NaN
constant: false
notes: FORMULA: C222H356N15O194S11 CHARGE: -11
initial concentration: 1.0
is: SBO:0000247

metaR Htg
product: MODEL1310110023#
is: SBO:0000185
reactant: MODEL1310110023#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true
fast: false
name: proton diffusion (Golgi)
kinetic law: MODEL1310110023#

metaM atp e
is: HMDB00538
constant: false
initial concentration: 1.0
is: C00002
type: Species
is: CHEBI:57299
name: ATP(4-)
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaM grdp x
is: HMDB01285
notes: FORMULA: C10H17O7P2 CHARGE: -3 INCHI: InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/p-3/b10-7+ HEPATONET_1.0_ABBREVIATION: HC00288 EHMN_ABBREVIATION: C00341
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:58057
name: geranyl diphosphate(3-)
has only substance units: false
is: SBO:0000247
boundary condition: false

metaR RE3347C
kinetic law: MODEL1310110023#
is described by: ECO:0000000
product: MODEL1310110023#
is: SBO:0000176
name: RE3347
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
reversible: true
reactant: MODEL1310110023#
type: Reaction
fast: false

metaR PYAM5POr
fast: false
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:6380540 NOTES:NCD IT
name: pyridoxamine 5'-phosphate oxidase
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.4.3.5
reversible: true
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
type: Reaction
reactant: MODEL1310110023#
is described by: ECO:0000269
is: SBO:0000176

metaR 3SALAASPm
is: SBO:0000185
kinetic law: MODEL1310110023#
name: cysteinesulfinate-aspartate mitochondrial shuttle
notes: GENE_ASSOCIATION: (10165.1) or (8604.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:PMID:486467 MM
is described by: ECO:0000304
product: MODEL1310110023#
fast: false
reversible: true
modifier: MODEL1310110023#
reactant: MODEL1310110023#
type: Reaction

metaM naglc2p U c
is: SBO:0000247
initial amount: NaN
is: CHEBI:18278
type: Species
initial concentration: 1.0
constant: false
name: N-Acetyl-D-glucosaminyldiphosphodolichol, human uterine homolog
notes: FORMULA: C1105H1810N10O120P20 CHARGE: -20 INCHI: InChI=1S/C33H59NO12P2/c1-23(2)12-8-13-24(3)14-9-15-25(4)16-10-17-26(5)18-11-19-27(6)20-21-43-47(39,40)46-48(41,42)45-33-30(34-28(7)36)32(38)31(37)29(22-35)44-33/h12,14,16,18,27,29-33,35,37-38H,8-11,13,15,17,19-22H2,1-7H3,(H,34,36)(H,39,40)(H,41,42)/b24-14+,25-16+,26-18-/t27?,29-,30-,31-,32-,33-/m1/s1
has only substance units: false
boundary condition: false

metaR r1975
kinetic law: MODEL1310110023#
product: MODEL1310110023#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110023#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reactant: MODEL1310110023#
fast: false
is described by: ECO:0000000

metaR FACOAL2251
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reversible: true
product: MODEL1310110023#
name: fatty-acid--CoA ligase
fast: false
type: Reaction
modifier: MODEL1310110023#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#

metaR COQ7m
modifier: MODEL1310110023#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110023#
type: Reaction
is: SBO:0000176
name: Ubiquinone biosynthesis COQ7
reversible: false
reactant: MODEL1310110023#
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (10229.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_1.14.13.- IT

metaM succ e
type: Species
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
name: succinate(2-)
initial concentration: 1.0
constant: false
is: HMDB00254
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:30031

metaM ru5p D r
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB00618
initial amount: NaN
constant: false
is: CHEBI:58121
has only substance units: false
name: D-ribulose 5-phosphate(2-)
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
initial concentration: 1.0

metaM fucacgalfucgalacglcgalgluside hs c
is: C00445
name: (Gal)2 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)2 (Cer)1
initial concentration: 1.0
is: HMDB01354
has only substance units: false
boundary condition: false
is: CHEBI:57455
notes: FORMULA: C64H112N3O35FULLRCO CHARGE: 0
type: Species
constant: false
is: SBO:0000247
initial amount: NaN

metaM pglyc hs c
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
is: CHEBI:60523
is: SBO:0000247
initial concentration: 1.0
name: phosphatidylglycerol(1-)
constant: false

metaR NRPPHRt4 2 r
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
name: Norepinephrine reversible transport in via sodium symport (1:2)
fast: false
is described by: ECO:0000269
product: MODEL1310110023#
reversible: true
kinetic law: MODEL1310110023#
type: Reaction
reactant: MODEL1310110023#
is: SBO:0000185
modifier: MODEL1310110023#

metaR r0596
reversible: false
product: MODEL1310110023#
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
type: Reaction
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
fast: false
is: SBO:0000176

metaR DOLPMT U
notes: GENE_ASSOCIATION: (54344.2 and 8818.1 and 8813.1) or (8818.2 and 54344.1 and 8813.1) or (8818.1 and 54344.1 and 8813.1) or (54344.2 and 8818.2 and 8813.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.83 Confidence Level: 0 AUTHORS: PMID:11420690 NOTES:NCD
name: Dolichyl-phosphate D-mannosyltransferase (uterus)
modifier: MODEL1310110023#
reactant: MODEL1310110023#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reversible: false
fast: false
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.4.1.83
product: MODEL1310110023#

metaM f1a l
notes: FORMULA: C22H37N2O15X CHARGE: 0
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
name: F1alpha
is: HMDB02917
is: CHEBI:17151

metaR Htr
fast: false
reactant: MODEL1310110023#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110023#
type: Reaction
name: H transporter, endoplasmic reticulum
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ

metaR MANtly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110023#
type: Reaction
reversible: false
fast: false
name: mannose efflux from lysosome
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000000

metaR ACALDtm
is: SBO:0000185
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:9028626 NOTES:NCD
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110023#
fast: false
reactant: MODEL1310110023#
name: acetaldehyde mitochondrial diffusion
type: Reaction

metaR r2327
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110023#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
is: SBO:0000185
product: MODEL1310110023#
reactant: MODEL1310110023#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110023#_af16437f_d1af_46d1_bac4_edc42f468bd6
is: SBO:0000252
is encoded by: hsa:8394
initial amount: NaN
is: Q99755
constant: false
name: PIP5K1A
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species

metaR S4TASE1ly
reactant: MODEL1310110023#
is described by: ECO:0000000
product: MODEL1310110023#
is: SBO:0000176
name: N-acetylgalactosamine-4-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
reversible: true
modifier: MODEL1310110023#
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.12
kinetic law: MODEL1310110023#
type: Reaction

metaM atp c
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
name: ATP(4-)
is: HMDB00538
initial amount: NaN
is: CHEBI:30616
is: SBO:0000247
is: C00002
type: Species

metaM txa2 e
is: CHEBI:57445
initial amount: NaN
name: thromboxane A2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
type: Species
has only substance units: false
constant: false
boundary condition: false
is: HMDB01452
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110023#_e65b6ba5_3172_4c95_9e90_adc055ccea8a
constant: false
initial concentration: NaN
type: Species
is: P05062
name: ALDOB
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:229
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_2d6f53e4_50c2_4a03_b05f_c7e694c1a086
is: P07205
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5232
initial concentration: NaN
has only substance units: false
constant: false
type: Species
name: PGK2

http://identifiers.org/biomodels.db/MODEL1310110023#_46f59aad_c756_44f9_bddb_7d245c7192ca
is encoded by: hsa:5169
is: SBO:0000252
is: Q308M7
boundary condition: true
has only substance units: false
initial amount: NaN
name: ENPP3
constant: false
type: Species
initial concentration: NaN

metaM dutp c
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
initial amount: NaN
type: Species
is: C00460
initial concentration: 1.0
is: HMDB01191
is: SBO:0000247
is: CHEBI:17625
has only substance units: false
boundary condition: false
constant: false
name: dUTP

http://identifiers.org/biomodels.db/MODEL1310110023#_f762861b_1dbc_41ea_9923_ef84231a9f96
boundary condition: true
name: PPCDC
is: Q96CD2
has only substance units: false
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:60490
is: SBO:0000252

metaM m4masn g
initial amount: NaN
constant: false
is: C05881
type: Species
name: (alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
notes: FORMULA: C46H77N2O35X CHARGE: 0
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaM pglyc hs e
name: phosphatidylglycerol(1-)
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
type: Species
is: CHEBI:60523
initial amount: NaN
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096

http://identifiers.org/biomodels.db/MODEL1310110023#_fb2ea9c6_f2ad_4082_ac76_95298c5f16a5
has only substance units: false
is: B7Z2T0
is encoded by: hsa:478
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
name: ATP1A3
boundary condition: true
is: SBO:0000252

metaR r2326
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110023#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
fast: false
product: MODEL1310110023#
is: SBO:0000185
reactant: MODEL1310110023#
is described by: ECO:0000000

metaM gpi prot hs r
name: {[(Prot-PE-Man),(PE)-Man],[PE]}-Man-GlcN-acylPI
notes: FORMULA: C55H106N4O38P4FULLRCO2FULLR2CO2X CHARGE: 0
initial amount: NaN
is: HMDB00220
is: SBO:0000247
is: CHEBI:7896
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
is: C00249

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

metaM icit x
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
is: HMDB00193
is: CHEBI:16087
constant: false
initial amount: NaN
name: isocitrate(3-)

http://identifiers.org/biomodels.db/MODEL1310110023#_ed5431e4_dd07_4b57_8a8f_ea2caa0a2138
boundary condition: true
constant: false
name: ST3GAL3
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:6487
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_0ec051a4_c8c9_48f9_af9f_296d2a89529e
name: SLC7A11
initial amount: NaN
is: Q9UPY5
boundary condition: true
has only substance units: false
is encoded by: hsa:23657
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_ddcd44f2_cec7_4a67_9d5c_5020f1ddd141
name: _W87865_1_c
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:W87865
boundary condition: true
initial amount: NaN
type: Species

metaM din e
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:28997
constant: false
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
initial concentration: 1.0
is: C05512
is: HMDB00071
name: Deoxyinosine

http://identifiers.org/biomodels.db/MODEL1310110023#_cffd8cf8_0086_4f37_8dfc_5665125b555e
initial amount: NaN
is: Q9H2U2
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
name: PPA2
constant: false
is encoded by: hsa:27068
is: SBO:0000252

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

metaR r2329
product: MODEL1310110023#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110023#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110023#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110023#_8afdbe7c_4e56_4afb_9bf6_f8fe23b18233
initial concentration: NaN
type: Species
is encoded by: hsa:4594
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: P22033
constant: false
boundary condition: true
name: MUT

metaR RE1526M
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
modifier: MODEL1310110023#
type: Reaction
reactant: MODEL1310110023#
product: MODEL1310110023#
is: SBO:0000176
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
name: RE1526
reversible: true
fast: false

metaM prostgi2 r
is: SBO:0000247
is: CHEBI:57403
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
name: prostaglandin I2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
is: HMDB01335

metaM txa2 c
name: thromboxane A2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:57445
is: HMDB01452
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_6ad70251_9586_4920_9cae_4b47b09dfb46
type: Species
is: P31350
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6241
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: RRM2

metaR r0488
reversible: true
type: Reaction
fast: false
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34
product: MODEL1310110023#
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:
is: SBO:0000176

metaR r1978
modifier: MODEL1310110023#
fast: false
reversible: false
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
type: Reaction

metaR F1PGT
fast: false
notes: GENE_ASSOCIATION: (8790.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.30 Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110023#
type: Reaction
reversible: true
name: fucose-1-phosphate guanylyltransferase
is: SBO:0000176
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.7.30
kinetic law: MODEL1310110023#

metaR r1640
modifier: MODEL1310110023#
reversible: true
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
fast: false
type: Reaction
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110023#_ba4c9877_b143_444e_b527_105e01a0ebff
initial amount: NaN
constant: false
is encoded by: hsa:57171
initial concentration: NaN
name: DOLPP1
is: SBO:0000252
type: Species
is: Q86YN1
boundary condition: true
has only substance units: false

metaR XOL7AONEtr
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
product: MODEL1310110023#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110023#
fast: false
name: lipid, flip-flop intracellular transport
is: SBO:0000185
kinetic law: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_9fffb1d7_4358_41ac_86a3_7aa136158686
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2530
has only substance units: false
is: SBO:0000252
is: B4DFS7
boundary condition: true
name: FUT8
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_bc8ef2a4_3933_4faf_9ec7_c02a67327d5b
has only substance units: false
constant: false
is encoded by: hsa:4694
name: NDUFA1
is: SBO:0000252
type: Species
initial concentration: NaN
is: Q6IBB5
boundary condition: true
initial amount: NaN

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

metaR ATPtx
kinetic law: MODEL1310110023#
type: Reaction
reactant: MODEL1310110023#
is described by: ECO:0000000
fast: false
name: ATP transporter, peroxisomal
is: SBO:0000185
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
reversible: true

metaR FAS140COA
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
is described by: ECO:0000269
fast: false
name: fatty-acyl-CoA synthase (n-C14:0CoA)
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110023#
is: SBO:0000176
modifier: MODEL1310110023#
type: Reaction
reversible: false

metaR r2328
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
kinetic law: MODEL1310110023#
fast: false
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000000
type: Reaction

metaR HDCEAtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
is: SBO:0000185
name: fatty acid transport via diffusion
reactant: MODEL1310110023#
fast: false
product: MODEL1310110023#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_bceb3c4a_f606_4b25_9234_5a826f7dc370
initial amount: NaN
constant: false
is: O14939
boundary condition: true
type: Species
name: PLD2
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5338
initial concentration: NaN

metaM aicar e
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H13N4O8P CHARGE: -2
type: Species
is: C04677
initial amount: NaN
is: HMDB01517
constant: false
boundary condition: false
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
is: CHEBI:58475

metaM ksii core2 deg5 l
notes: FORMULA: C50H82N4O38SX CHARGE: -1
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:12936
initial concentration: 1.0
is: HMDB00143
constant: false
name: keratan sulfate II (core 2-linked), degradation product 5
type: Species
initial amount: NaN

metaR FAOXC226m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:6)m
type: Reaction

metaM ksi pre22 g
has only substance units: false
initial amount: NaN
is: CHEBI:58053
is: C00130
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 22
notes: FORMULA: C185H297N13O150S6X CHARGE: -7
is: HMDB00175
boundary condition: false
constant: false
type: Species
initial concentration: 1.0

metaR r2323
kinetic law: MODEL1310110023#
is described by: ECO:0000000
reversible: true
type: Reaction
reactant: MODEL1310110023#
fast: false
is: SBO:0000185
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR r1540
is version of: http://identifiers.org/ec-code/1.17.4.1
type: Reaction
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
modifier: MODEL1310110023#
reversible: false
is described by: ECO:0000000
is: SBO:0000185
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
fast: false
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:

metaM 4fumacac c
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1+ HEPATONET_1.0_ABBREVIATION: HC00648 EHMN_ABBREVIATION: C01061
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB01268
has only substance units: false
name: 4-fumarylacetoacetate(2-)
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:18034

metaM din c
initial amount: NaN
type: Species
boundary condition: false
is: C05512
is: CHEBI:28997
constant: false
name: Deoxyinosine
initial concentration: 1.0
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
has only substance units: false
is: SBO:0000247
is: HMDB00071

metaM glac r
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
is: CHEBI:18268
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
name: D-glucurono-6,3-lactone
is: HMDB06355
boundary condition: false
has only substance units: false
constant: false

metaR r0591
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110023#
type: Reaction
kinetic law: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
product: MODEL1310110023#
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
reversible: true
fast: false
reactant: MODEL1310110023#

metaM formcoa x
initial concentration: 1.0
is: HMDB03419
has only substance units: false
is: CHEBI:57376
initial amount: NaN
is: SBO:0000247
type: Species
name: formyl-CoA(4-)
notes: FORMULA: C22H32N7O17P3S CHARGE: -4 INCHI: InChI=1S/C22H36N7O17P3S/c1-22(2,17(33)20(34)25-4-3-13(31)24-5-6-50-11-30)8-43-49(40,41)46-48(38,39)42-7-12-16(45-47(35,36)37)15(32)21(44-12)29-10-28-14-18(23)26-9-27-19(14)29/h9-12,15-17,21,32-33H,3-8H2,1-2H3,(H,24,31)(H,25,34)(H,38,39)(H,40,41)(H2,23,26,27)(H2,35,36,37)/p-4/t12-,15-,16-,17+,21-/m1/s1 EHMN_ABBREVIATION: C00798
constant: false
boundary condition: false

metaM cysam c
has only substance units: false
boundary condition: false
name: cysteaminium
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678
is: HMDB02991
initial amount: NaN
is: CHEBI:58029
is: SBO:0000247

metaR ASNALANaEx
modifier: MODEL1310110023#
is: SBO:0000185
name: L-alanine/L-asparagine Na-dependent exchange (Asn-L in)
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
type: Reaction
fast: false
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_b396d4ef_bb29_42b6_9224_05f92ca8daab
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:10164
is: Q8NCG5
is: SBO:0000252
name: CHST4

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

metaR EX meoh LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: methanol exchange
type: Reaction

metaR r2322
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
kinetic law: MODEL1310110023#
type: Reaction
product: MODEL1310110023#
reversible: true
reactant: MODEL1310110023#
is described by: ECO:0000000

metaM prpp e
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:58017
is: HMDB00280
boundary condition: false
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
initial amount: NaN
constant: false
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
initial concentration: 1.0

metaR RE2973N
modifier: MODEL1310110023#
is described by: ECO:0000000
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:
type: Reaction
name: RE2973
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.154
reversible: true
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_83b96811_7e86_4a98_a93e_2f2a50120537
boundary condition: true
is: SBO:0000252
is encoded by: hsa:23428
name: SLC7A8
initial concentration: NaN
type: Species
is: Q9UHI5
has only substance units: false
initial amount: NaN
constant: false

metaR r0590
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
reversible: false
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110023#
fast: false
type: Reaction
reactant: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110023#_056aba59_1540_4ffa_a53c_b94651bb97f7
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:7371
constant: false
is: Q9BZX2
type: Species
name: UCK2

metaR S6T15g
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.8.2.21
is version of: http://identifiers.org/ec-code/2.8.2.17
reversible: false
reactant: MODEL1310110023#
product: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
modifier: MODEL1310110023#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110023#_f2541050_832e_409e_b0db_48c9aa55aecf
name: SLC16A1
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: B4DKS0
boundary condition: true
is encoded by: hsa:6566
initial concentration: NaN
is: SBO:0000252

metaR NACHEXA18ly
kinetic law: MODEL1310110023#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110023#
reversible: false
product: MODEL1310110023#
name: beta-N-acetylhexosaminidase A, lysosomal
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_46407400_6784_4bc9_9ea7_c85e37c4487a
has only substance units: false
type: Species
name: CHST3
boundary condition: true
is encoded by: hsa:9469
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: Q7LGC8

metaR SUCCt2m
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
name: succinate transport, mitochondrial
modifier: MODEL1310110023#
reversible: true
fast: false
type: Reaction
is described by: ECO:0000269
product: MODEL1310110023#
is: SBO:0000185
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#

metaR CYTK2n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP),nuclear
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
product: MODEL1310110023#
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110023#
reversible: true
fast: false

metaR HSAT1ly
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
fast: false
product: MODEL1310110023#
reactant: MODEL1310110023#
type: Reaction
reversible: false
is described by: ECO:0000000
is: SBO:0000185
name: heparan-glucosaminide N-acetyltransferase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110023#_732c23d5_3745_4a8a_9bf2_77daa5385e7f
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: _AI926493_1_m
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AI926493

http://identifiers.org/biomodels.db/MODEL1310110023#_6aecb98e_5533_47cc_9d33_b2e7b6a4f3e1
is encoded by: hsa:5286
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is: O00443
type: Species
is: SBO:0000252
name: PIK3C2A
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_b374e0a7_44be_438f_9e85_aa3d9c9b6ef8
initial concentration: NaN
name: PIK3R3
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:8503
is: Q92569
has only substance units: false

metaM ksi pre7 g
is: HMDB00175
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C115H187N8O85SX CHARGE: -2
is: CHEBI:58053
initial amount: NaN
boundary condition: false
constant: false
is: C00130
type: Species
name: keratan sulfate I biosynthesis, precursor 7
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110023#_f6431398_68be_40c7_9b9f_9b4ebbbbf5dd
initial amount: NaN
boundary condition: true
constant: false
type: Species
is: Q9NY97
name: B3GNT2
has only substance units: false
initial concentration: NaN
is encoded by: hsa:10678
is: SBO:0000252

metaM cgly c
initial concentration: 1.0
name: L-cysteinylglycine
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
constant: false
type: Species
boundary condition: false
is: CHEBI:4047
is: SBO:0000247
is: HMDB00078

http://identifiers.org/biomodels.db/MODEL1310110023#_6da05663_5597_4d5e_8e42_1e2736d70eeb
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1718
is: SBO:0000252
is: Q15392
initial amount: NaN
type: Species
name: DHCR24
constant: false

metaR MEVK1c
notes: GENE_ASSOCIATION: (4598.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book.
is: SBO:0000176
fast: false
modifier: MODEL1310110023#
name: mevalonate kinase (atp) cytosol
reactant: MODEL1310110023#
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110023#
reversible: false
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.1.36

metaR SR5ARr
name: 3-oxo-5-alpha-steroid 4-dehydrogenase
is described by: ECO:0000134
is: SBO:0000176
reversible: false
type: Reaction
product: MODEL1310110023#
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.5
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (6716.1) or (6715.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.99.5 Confidence Level: 4 AUTHORS: PMID:2339109 NOTES:there are actually two types, but the difference between them lies in optimal pH function - grouped as one reaction at his point to eliminate redundancy. NADP known to be cofactor NJ. human 5alpha-HSD activity determined in transfected COS cells using C-14 labelled testosterone as substrate
reactant: MODEL1310110023#

metaM fadh2 c
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
initial concentration: 1.0
is: CHEBI:58307
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: FADH2(2-)
constant: false
has only substance units: false
type: Species
is: HMDB01197

metaR FDH
is version of: http://identifiers.org/ec-code/1.5.1.6
fast: false
notes: GENE_ASSOCIATION: (10840.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.2.1.2 Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000304
kinetic law: MODEL1310110023#
type: Reaction
name: formate dehydrogenase
modifier: MODEL1310110023#
reversible: false
reactant: MODEL1310110023#
is: SBO:0000176
product: MODEL1310110023#

metaR ACCOAC
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

metaM ppcoa x
type: Species
constant: false
is: HMDB01275
is: CHEBI:57392
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: C00100
is: SBO:0000247
name: Propanoyl-CoA
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100

metaR GLCAASE7ly
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.31
is: SBO:0000176
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
reactant: MODEL1310110023#
fast: false
name: beta-glucuronidase, lysosomal
product: MODEL1310110023#
reversible: false

metaM 44mctr r
initial amount: NaN
is: CHEBI:17813
type: Species
is: SBO:0000247
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
boundary condition: false
constant: false
has only substance units: false
is: HMDB01023
initial concentration: 1.0
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455

metaR BTNPLm
reversible: false
product: MODEL1310110023#
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
fast: false
name: holocarboxylase synthestase (biotin protein ligase), mitochondrial
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.3.4.10
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
reactant: MODEL1310110023#
type: Reaction

metaR MI1345PP
reversible: false
fast: false
is: SBO:0000176
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
product: MODEL1310110023#
modifier: MODEL1310110023#
type: Reaction
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.1.3.56
is version of: http://identifiers.org/ec-code/3.1.3.86
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.1.3.36
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
is described by: ECO:0000269

metaR r2325
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110023#
type: Reaction
kinetic law: MODEL1310110023#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
reactant: MODEL1310110023#
reversible: true
is described by: ECO:0000000

metaR EX fucacgalfucgalacglcgalgluside hs LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (Gal)2 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)2 (Cer)1 exchange
type: Reaction

metaR r2324
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110023#
type: Reaction
reactant: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110023#

metaR r0483
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
product: MODEL1310110023#
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110023#
is: SBO:0000176

metaM succ m
initial amount: NaN
has only substance units: false
name: Succinate
is: HMDB00254
type: Species
is: CHEBI:30031
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: C00042
is: SBO:0000247
constant: false

metaR DHFR
modifier: MODEL1310110023#
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
reversible: true
product: MODEL1310110023#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/1.5.1.3
name: dihydrofolate reductase
type: Reaction
fast: false

metaM prpp c
is: C00119
type: Species
is: CHEBI:58017
boundary condition: false
is: HMDB00280
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
name: 5-Phospho-alpha-D-ribose 1-diphosphate
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110023#_97f1eae8_6de7_4410_83e4_8afc7abfc38a
is encoded by: hsa:9091
has part: P57054
has only substance units: false
boundary condition: true
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
initial concentration: NaN
is encoded by: hsa:51227
initial amount: NaN
has part: B2RAU6
type: Species
is encoded by: hsa:5277
is: SBO:0000297
is encoded by: hsa:5279
constant: false

metaR OMPDC
reactant: MODEL1310110023#
type: Reaction
kinetic law: MODEL1310110023#
reversible: false
fast: false
product: MODEL1310110023#
modifier: MODEL1310110023#
is: SBO:0000176
name: orotidine-5'-phosphate decarboxylase
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 4.1.1.23 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
is version of: http://identifiers.org/ec-code/2.4.2.10
is described by: ECO:0000269

metaM cgly e
constant: false
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:4047
name: L-cysteinylglycine
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
is: HMDB00078
initial amount: NaN

metaR MTHFD2
name: methylenetetrahydrofolate dehydrogenase (NAD)
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
product: MODEL1310110023#
is: SBO:0000176
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.5.4.9
is described by: ECO:0000134
kinetic law: MODEL1310110023#
reversible: true
fast: false
type: Reaction
modifier: MODEL1310110023#

metaM ksi pre30 g
name: keratan sulfate I biosynthesis, precursor 30
is: SBO:0000247
is: C00130
is: CHEBI:58053
notes: FORMULA: C219H350N15O184S9X CHARGE: -10
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB00175

http://identifiers.org/biomodels.db/MODEL1310110023#_2001bf20_9ccb_4164_9f2d_98e5f44fefa1
constant: false
is: E9PCI1
is: SBO:0000252
boundary condition: true
name: ACP2
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:53
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_55c30e4e_47ba_448e_92ae_bbc34a97cbb7
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
type: Species
name: EGFR
initial amount: NaN
is encoded by: hsa:1956
is: P00533
initial concentration: NaN

metaR r1646
modifier: MODEL1310110023#
type: Reaction
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110023#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
product: MODEL1310110023#

metaM 4mptnl e
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB01318
has only substance units: false
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373
initial concentration: 1.0
is: CHEBI:17998
name: 4-methylpentanal
constant: false

metaR ALAGLNexR
fast: false
reversible: true
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110023#
type: Reaction
modifier: MODEL1310110023#
is described by: ECO:0000304
is: SBO:0000185
name: L-alanine/glutamine reversible exchange
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_bc6443f2_8af4_49cc_8816_ab57f34f01f7
is encoded by: hsa:766
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
name: CA7
is: P43166
is: SBO:0000252
initial concentration: NaN
constant: false

metaR G6Pter
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (2542.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11032333,PMID:11140953,PMID:11879177,PMID:9428641 NOTES:NCD
is described by: ECO:0000269
reversible: true
name: glucose 6-phosphate endoplasmic reticular transport via diffusion
fast: false
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
product: MODEL1310110023#
modifier: MODEL1310110023#

metaM cs a deg2 l
has only substance units: false
boundary condition: false
constant: false
is: HMDB00127
is: CHEBI:15748
initial concentration: 1.0
notes: FORMULA: C37H55NO38S2 CHARGE: -4
initial amount: NaN
type: Species
is: SBO:0000247
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 2

http://identifiers.org/biomodels.db/MODEL1310110023#_e69c48d8_7968_4282_818d_0e5229b3edac
initial concentration: NaN
name: MIA3
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:375056
is: SBO:0000252
boundary condition: true
has only substance units: false
is: Q5JRA6

metaM gpi sig r
is: CHEBI:58190
type: Species
is: HMDB00224
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: Y CHARGE: 0
constant: false
initial concentration: 1.0
name: glycophosphatidylinositol (GPI) signal sequence (C-terminal peptide)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110023#_da36818a_e749_4496_8743_a59a4038ecec
initial amount: NaN
is: Q5SPY7
boundary condition: true
name: ENTPD2
type: Species
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:954
is: SBO:0000252

metaR r1544
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110023#
product: MODEL1310110023#
type: Reaction

metaR CORE3GTg
reactant: MODEL1310110023#
name: Core 3 beta-GlcNAc-transferase, Golgi apparatus
notes: GENE_ASSOCIATION: (192134.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.147 Confidence Level: 0 AUTHORS: PMID:11821425 NOTES:NCD
reversible: false
modifier: MODEL1310110023#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
product: MODEL1310110023#
kinetic law: MODEL1310110023#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_96df5c83_4e7a_4228_b131_3cfd410cfccf
has only substance units: false
boundary condition: true
initial amount: NaN
is: E9PEI9
is: SBO:0000252
is encoded by: hsa:4047
initial concentration: NaN
type: Species
constant: false
name: LSS

metaR Q10H2e
fast: false
type: Reaction
reactant: MODEL1310110023#
is described by: ECO:0000134
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.
is: SBO:0000185
name: transport of ubiquinol into lymph
product: MODEL1310110023#
reversible: true

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

metaR r1645
reactant: MODEL1310110023#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110023#
is: SBO:0000185
kinetic law: MODEL1310110023#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
product: MODEL1310110023#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110023#_3854cf63_18ac_4e2b_9839_c175840edf3f
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110023#_c906e399_b548_48e1_aeb5_6d2907db4ec0
name: PDE9A
type: Species
is: SBO:0000252
is encoded by: hsa:5152
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false

metaR r1547
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110023#
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR FAOXC9C7m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C9-->C7)m
type: Reaction

metaR AKR1C42
is: SBO:0000176
type: Reaction
fast: false
product: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.1.1.225
reversible: false
is described by: ECO:0000269
name: aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)

metaR r1648
type: Reaction
reactant: MODEL1310110023#
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_7f2defe8_c2cc_4512_aa3b_dbd183bc6667
has only substance units: false
type: Species
is encoded by: hsa:52
constant: false
boundary condition: true
is: SBO:0000252
is: Q59EH3
name: ACP1
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_23c11407_5de9_41ed_a17d_7847043d4ebf
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
is: O14772
boundary condition: true
is encoded by: hsa:8790
name: FPGT
has only substance units: false

metaM 6thf e
name: hexaglutamyl folate (THF)
initial amount: NaN
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/169691
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_2976eef5_5cbe_4a52_8c06_70d58b9f9b1a
is encoded by: hsa:4710
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
name: NDUFB4
type: Species
is: SBO:0000252
is: O95168

metaM xol7ah3 c
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: 5beta-cholestane-3alpha,7alpha,26-triol
is: CHEBI:28540
boundary condition: false
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
is: HMDB12455
type: Species

metaR NCNt
reactant: MODEL1310110023#
modifier: MODEL1310110023#
reversible: true
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
product: MODEL1310110023#
fast: false
is described by: ECO:0000269
is: SBO:0000185
name: Na+/Ca2+-NH4+ exchange
type: Reaction
kinetic law: MODEL1310110023#

metaR CYSTGLUex
notes: GENE_ASSOCIATION: (23657.1 and 6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
name: L-cystine/L-glutamate exchanger
type: Reaction
reactant: MODEL1310110023#
fast: false
modifier: MODEL1310110023#
is: SBO:0000185
kinetic law: MODEL1310110023#
is described by: ECO:0000269
reversible: false
product: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_bffd7dca_6dbe_4ec2_a13f_75b30a39c2a6
is: SBO:0000252
is encoded by: hsa:38
name: ACAT1
type: Species
initial amount: NaN
is: P24752
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN

metaR r1546
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110023#

metaM ppcoa c
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: HMDB01275
initial amount: NaN
boundary condition: false
is: C00100
name: Propanoyl-CoA
type: Species
is: CHEBI:57392

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

metaM phe L e
is: CHEBI:17295
constant: false
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
initial concentration: 1.0
initial amount: NaN
name: L-phenylalanine
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB00159

http://identifiers.org/biomodels.db/MODEL1310110023#_65e8ce06_8804_4a25_8165_44038edcbbf1
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is: Q12882
initial concentration: NaN
constant: false
name: DPYD
is: SBO:0000252
is encoded by: hsa:1806

metaR RE1523M
is: SBO:0000176
reactant: MODEL1310110023#
name: RE1523
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
modifier: MODEL1310110023#
reversible: true
kinetic law: MODEL1310110023#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
type: Reaction
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR r1647
modifier: MODEL1310110023#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000000
fast: false

metaM hs deg17 l
is: HMDB02704
type: Species
initial amount: NaN
name: heparan sulfate, degradation product 17
is: CHEBI:21338
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C43H65N2O48S4 CHARGE: -5
has only substance units: false
boundary condition: false

metaR IDOURtly
reversible: true
reactant: MODEL1310110023#
type: Reaction
kinetic law: MODEL1310110023#
name: iduronate transport into lysososme
is: SBO:0000185
modifier: MODEL1310110023#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261,PMID:9852127 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 (for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD added IdoA reaction - NCD
fast: false
product: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_18c004f8_ac82_4a0a_a190_4420f8d682f3
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:10195
name: ALG3
initial concentration: NaN
constant: false
has only substance units: false

metaR OCD11CRNCPT2
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_d2985d03_05b1_495c_87b2_0980ca841615
is encoded by: hsa:257202
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
name: GPX6
is: P59796
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_81920a35_082d_48d1_aa88_f150a605accc
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: NME1
type: Species
is: SBO:0000252
is encoded by: hsa:4830
has only substance units: false

metaR MELATNOX
notes: GENE_ASSOCIATION: (1557.1) or (1543.1) or (1545.1) or (1544.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15616152 NOTES:SAB made up name
reversible: false
kinetic law: MODEL1310110023#
fast: false
is version of: http://identifiers.org/ec-code/1.14.14.1
is: SBO:0000176
product: MODEL1310110023#
name: Melatonin:NADP oxidoreductase
is described by: ECO:0000269
modifier: MODEL1310110023#
reactant: MODEL1310110023#
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.13.48

metaM andrstrn r
type: Species
name: androsterone
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
is: HMDB00031
constant: false
boundary condition: false
is: CHEBI:16032
has only substance units: false

metaM pristanal c
initial amount: NaN
is: CHEBI:49189
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB01958
boundary condition: false
initial concentration: 1.0
name: pristanal
notes: FORMULA: C19H38O CHARGE: 0 INCHI: InChI=1S/C19H38O/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20/h15-19H,6-14H2,1-5H3
constant: false

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

metaM aicar c
is: HMDB01517
boundary condition: false
initial amount: NaN
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
is: CHEBI:58475
is: C04677
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
has only substance units: false
type: Species

metaR S2TASE2ly
is version of: http://identifiers.org/ec-code/3.1.6.13
type: Reaction
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
product: MODEL1310110023#
reversible: false
modifier: MODEL1310110023#
is described by: ECO:0000000
name: iduronate-2-sulfatase, lysosomal

metaR GALASE18ly
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
fast: false
is described by: ECO:0000000
is: SBO:0000176
reversible: false
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110023#
type: Reaction

metaR r1549
product: MODEL1310110023#
kinetic law: MODEL1310110023#
is: SBO:0000185
reactant: MODEL1310110023#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_0bffa489_14b4_42d9_b680_db2ef1ea195c
type: Species
is: P11310
constant: false
name: ACADM
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:34
initial amount: NaN
is: SBO:0000252

metaM phyt c
has only substance units: false
is: CHEBI:37257
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
name: phytanate
is: HMDB00801
initial amount: NaN
type: Species

metaR TPI
is version of: http://identifiers.org/ec-code/5.3.1.1
reactant: MODEL1310110023#
name: triose-phosphate isomerase
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
type: Reaction
is: SBO:0000176
product: MODEL1310110023#
reversible: true
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical

metaM hs deg18 l
is: SBO:0000247
has only substance units: false
is: CHEBI:17180
constant: false
initial amount: NaN
boundary condition: false
is: HMDB01352
type: Species
name: heparan sulfate, degradation product 18
initial concentration: 1.0
notes: FORMULA: C43H66N2O45S3 CHARGE: -4

metaR r0156
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.40
product: MODEL1310110023#
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
modifier: MODEL1310110023#
fast: false
reversible: false
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
is described by: ECO:0000000
type: Reaction

metaR 3HKYNAKGAT
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.64
is described by: ECO:0000304
modifier: MODEL1310110023#
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.7
type: Reaction
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
product: MODEL1310110023#
kinetic law: MODEL1310110023#
reversible: false
reactant: MODEL1310110023#

metaR r0267
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
reactant: MODEL1310110023#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.5.1.9
modifier: MODEL1310110023#
type: Reaction
kinetic law: MODEL1310110023#
reversible: true
product: MODEL1310110023#
is: SBO:0000176
fast: false

metaR r1642
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110023#
modifier: MODEL1310110023#
fast: false
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110023#
type: Reaction
is described by: ECO:0000000

metaM fadh2 m
is: HMDB01197
name: Flavin adenine dinucleotide reduced
initial concentration: 1.0
is: CHEBI:58307
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
boundary condition: false
has only substance units: false
is: C01352

metaR r0268
fast: false
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.1
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
is version of: http://identifiers.org/ec-code/3.1.3.2
product: MODEL1310110023#
is: SBO:0000176
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_7662cbee_666d_4ee1_9562_eff67350def2
has only substance units: false
initial concentration: NaN
type: Species
name: ENTPD3
constant: false
initial amount: NaN
is encoded by: hsa:956
is: O75355
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110023#_8c365272_f8cb_4ac0_8132_0d71f70a685d
constant: false
type: Species
is encoded by: hsa:51095
is: Q96Q11
boundary condition: true
initial amount: NaN
name: TRNT1
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaR r1548
reversible: true
is: SBO:0000185
reactant: MODEL1310110023#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110023#

metaR RE1525M
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110023#
name: RE1525
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110023#
modifier: MODEL1310110023#

metaM arg L e
is: HMDB00517
initial amount: NaN
constant: false
is: CHEBI:32682
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
has only substance units: false
type: Species
initial concentration: 1.0
name: L-argininium(1+)
is: SBO:0000247
boundary condition: false

metaR r0157
kinetic law: MODEL1310110023#
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.3.4.2
product: MODEL1310110023#
type: Reaction
fast: false
is: SBO:0000176
reversible: false
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_be4201a3_1fbd_49f2_ad8b_86f41aa9ace7
type: Species
is encoded by: hsa:56894
is: Q9NRZ7
initial amount: NaN
has only substance units: false
name: AGPAT3
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252

metaR r1641
type: Reaction
product: MODEL1310110023#
fast: false
reactant: MODEL1310110023#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110023#
reversible: true
modifier: MODEL1310110023#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110023#_8af7eb50_f597_4d8d_8777_67ac0dc19f6c
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:27124
boundary condition: true
has only substance units: false
is: Q15735
constant: false
initial concentration: NaN
name: INPP5J

metaM sphmyln hs g
is: SBO:0000247
name: sphingomyelin betaine
initial concentration: 1.0
constant: false
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:58216

metaM HC01118 r
has only substance units: false
name: presqualene diphosphate(3-)
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
constant: false
initial amount: NaN
is: CHEBI:57310
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110023#_7f895451_da23_41a7_bbf4_b766a1e693bd
is: SBO:0000252
type: Species
is encoded by: hsa:51079
constant: false
boundary condition: true
is: Q9P0J0
initial amount: NaN
has only substance units: false
name: NDUFA13
initial concentration: NaN

metaR r1644
modifier: MODEL1310110023#
type: Reaction
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110023#
is described by: ECO:0000000
kinetic law: MODEL1310110023#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_0437dc9a_0d26_4c4e_8192_29c28ae044e0
is: A8K5J1
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:7372
initial concentration: NaN
boundary condition: true
constant: false
name: UMPS

metaM 2dpmhobq m
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C58H88O4 CHARGE: 0 INCHI: InChI=1S/C58H88O4/c1-43(2)23-14-24-44(3)25-15-26-45(4)27-16-28-46(5)29-17-30-47(6)31-18-32-48(7)33-19-34-49(8)35-20-36-50(9)37-21-38-51(10)39-22-40-52(11)41-42-54-53(12)55(59)57(61)58(62-13)56(54)60/h23,25,27,29,31,33,35,37,39,41,61H,14-22,24,26,28,30,32,34,36,38,40,42H2,1-13H3/b44-25+,45-27+,46-29+,47-31+,48-33+,49-35+,50-37+,51-39+,52-41+
initial amount: NaN
is: HMDB06484
is: CHEBI:50771
has only substance units: false
name: 2-decaprenyl-5-hydroxy-6-methoxy-3-methyl-1,4-benzoquinone
is: SBO:0000247

metaM sphmyln hs c
boundary condition: false
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: sphingomyelin betaine
constant: false
type: Species
is: CHEBI:58216

metaR RE1845C
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.3.1.65
is: SBO:0000176
fast: false
is described by: ECO:0000000
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 4 h[c] from compEHMN reaction as they were not necessary
product: MODEL1310110023#
name: RE1845
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110023#_5950a725_c582_4c13_ab21_a8a55effadca
is encoded by: hsa:AI971023
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
name: _AI971023_1_c
is: SBO:0000252
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110023#_dc02464a_6ea6_441c_9660_c45596b00357
is: Q53HE2
name: TPI1
is encoded by: hsa:7167
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN

metaR GLCNACASE3ly
is described by: ECO:0000000
fast: false
reactant: MODEL1310110023#
product: MODEL1310110023#
is: SBO:0000176
modifier: MODEL1310110023#
name: alpha-N-acetylglucosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.50
kinetic law: MODEL1310110023#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD

metaR HOXG
modifier: MODEL1310110023#
is described by: ECO:0000134
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.14.99.3
name: Heme oxygenase 1
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (3162.1) or (3163.1) SUBSYSTEM: Heme degradation EC Number: 1.14.99.3 Confidence Level: 0 AUTHORS: PMID:16356137 NOTES:TDV (4/28/2004) There are conflicting data on how many moles of NADPH consumed per mole of Biliverdine (Tenhunen 1969, Ryter, 2000). Heme oxygenase is a well known enzyme
reactant: MODEL1310110023#
fast: false
is: SBO:0000176
product: MODEL1310110023#

metaR ALR2
is version of: http://identifiers.org/ec-code/1.1.1.2
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.21
kinetic law: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
reversible: false
reactant: MODEL1310110023#
name: aldose reductase (methylglyoxal)
product: MODEL1310110023#
modifier: MODEL1310110023#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_f3e58724_f3ef_454a_b533_713c46faa691
initial concentration: NaN
is: D3DX95
has only substance units: false
name: CHAT
constant: false
is encoded by: hsa:1103
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252

metaR AG13T4g
modifier: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000176
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (10331.1) or (374907.1) or (146712.1) or (374907.2) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110023#
product: MODEL1310110023#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110023#
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_86371ccb_200e_4ee1_b06f_896e22c1e85f
has only substance units: false
type: Species
is encoded by: hsa:113026
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q8N3E9
name: PLCD3
initial concentration: NaN

metaR VALTA
reactant: MODEL1310110023#
reversible: true
name: valine transaminase
is described by: ECO:0000269
kinetic law: MODEL1310110023#
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
modifier: MODEL1310110023#
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.42
fast: false
is: SBO:0000176

metaM HC01501 c
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
notes: FORMULA: HO3S2 CHARGE: -1 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-1 EHMN_ABBREVIATION: C05529
is: CHEBI:33539
is: SBO:0000247
boundary condition: false
name: hydroxidodioxidosulfidosulfate(1-)
has only substance units: false

metaM 4mptnl c
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373
initial concentration: 1.0
has only substance units: false
name: 4-methylpentanal
type: Species
is: HMDB01318
is: CHEBI:17998
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110023#_1f9b9cd2_02cb_48e2_a8a6_8129620ee910
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
name: GUCY2D
initial concentration: NaN
type: Species
is encoded by: hsa:3000
is: Q02846
boundary condition: true

metaR r1643
reactant: MODEL1310110023#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110023#
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
type: Reaction
is: SBO:0000185
fast: false
reversible: true

metaM HC00342 c
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
has only substance units: false
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
name: cis-aconitate(3-)
is: SBO:0000247
is: CHEBI:16383
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110023#_88c45302_fc10_48bc_a94b_78bfa3b6072e
is encoded by: hsa:AI191472
initial concentration: NaN
has only substance units: false
name: _AI191472_1_c
type: Species
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR ALR3
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.1.1.21
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.2
is: SBO:0000176
name: aldose reductase (acetol)
kinetic law: MODEL1310110023#
type: Reaction
reactant: MODEL1310110023#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
modifier: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_b7afa498_b5e1_4c47_a2f3_5b384b4bd5d9
constant: false
initial amount: NaN
is: O94777
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8818
is: SBO:0000252
type: Species
has only substance units: false
name: DPM2

metaM arg L c
is: SBO:0000247
is: HMDB00517
is: CHEBI:32682
initial amount: NaN
has only substance units: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
constant: false
initial concentration: 1.0
name: L-argininium(1+)
type: Species
boundary condition: false

metaR PHETHPTOX2
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.14.16.1
reactant: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: (5053.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.14.16.1 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:9450897 NOTES:SAB unlumped form of PHETHPTOX according to PMID 10727395
type: Reaction
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)
reversible: false
product: MODEL1310110023#
modifier: MODEL1310110023#
is: SBO:0000176
is described by: ECO:0000269

metaM dcsptn1coa m
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205483
boundary condition: false
is: C16173
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
type: Species
constant: false
is: HMDB06513
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR FAOXC164m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)m
type: Reaction

metaR EX phyt LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phytanic acid exchange
type: Reaction

metaR EX crvnc LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC22:6 exchange
type: Reaction

metaR NDPK10n
reversible: true
is described by: ECO:0000304
is: SBO:0000176
fast: false
name: nucleoside-diphosphate kinase (ATP:dIDP), nuclear
product: MODEL1310110023#
reactant: MODEL1310110023#
modifier: MODEL1310110023#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions. . Presence in the nucleus

metaM xol7ah3 m
type: Species
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB12455
is: CHEBI:28540
initial amount: NaN
boundary condition: false
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
name: 5beta-cholestane-3alpha,7alpha,26-triol
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110023#_df2da914_15f5_4c85_b372_e1e1bf8f9da9
initial concentration: NaN
has only substance units: false
boundary condition: true
has part: B7Z2T0
name: ATP1A3:ATP1B1
is encoded by: hsa:481
type: Species
is encoded by: hsa:478
has part: A3KLL5
initial amount: NaN
constant: false
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110023#_d2a1e44d_be98_49a4_bcf9_5867711b466e
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
name: AKR1C4
is encoded by: hsa:1109
constant: false
initial amount: NaN
is: P17516

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

metaR ADEt
is described by: ECO:0000269
reversible: true
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD
name: adenine reversible transport, cytosol
reactant: MODEL1310110023#
modifier: MODEL1310110023#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110023#
fast: false

metaR URATEt
reversible: false
name: urate export from cytosol
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110023#
type: Reaction
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110023#
fast: false

metaM tetdecdicoa m
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: 5,8-tetradecadienoylcoa
has only substance units: false
constant: false
is: HMDB02288
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
type: Species

metaR r0377
is described by: ECO:0000000
reactant: MODEL1310110023#
type: Reaction
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
kinetic law: MODEL1310110023#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.7.4.3
product: MODEL1310110023#
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
fast: false

metaM ppcoa m
is: CHEBI:57392
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB01275
name: Propanoyl-CoA
initial concentration: 1.0
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: SBO:0000247
is: C00100
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_549e92f4_a85c_4bb4_b962_f2034db53673
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:22305
initial amount: NaN
type: Species
constant: false
name: _22305_1_c
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_7a8b0852_b67e_4765_8048_c20f9b6f0dae
constant: false
type: Species
initial amount: NaN
name: ADSL
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:158

metaM orot e
has only substance units: false
is: CHEBI:30839
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
name: orotate
is: HMDB00226

http://identifiers.org/biomodels.db/MODEL1310110023#_00ac586b_fdb6_4b33_9f4c_5ce4f364b371
is encoded by: hsa:10449
is: P42765
constant: false
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: ACAA2

metaM glyclt c
constant: false
has only substance units: false
boundary condition: false
name: glycolate
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:29805
is: HMDB00115
initial concentration: 1.0
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160

http://identifiers.org/biomodels.db/MODEL1310110023#_e6d85c6f_b5e4_4a74_9783_c4f8dfc9f10b
initial amount: NaN
is: Q8WUM9
boundary condition: true
constant: false
type: Species
initial concentration: NaN
name: SLC20A1
is encoded by: hsa:6574
has only substance units: false
is: SBO:0000252

metaR RE2974C
name: RE2974
fast: false
is: SBO:0000176
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (8395.1) or (23396.1) or (5305.1) or (8396.1) or (79837.1) or (8394.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.68
reversible: true
type: Reaction
product: MODEL1310110023#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.149
reactant: MODEL1310110023#

metaR ITCOALm
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
fast: false
product: MODEL1310110023#
is: SBO:0000176
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/6.2.1.5
is version of: http://identifiers.org/ec-code/6.2.1.4
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
is described by: ECO:0000212
reversible: true
type: Reaction
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_9e100e3f_da5b_467b_ba82_dd8e8792c0d5
type: Species
is encoded by: hsa:3030
has only substance units: false
name: HADHA
is: SBO:0000252
boundary condition: true
is: E9KL44
initial concentration: NaN
constant: false
initial amount: NaN

metaM nicrnt c
is: SBO:0000247
is: C01185
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
is: HMDB01132
type: Species
boundary condition: false
is: CHEBI:57502
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
name: Nicotinate D-ribonucleotide

http://identifiers.org/biomodels.db/MODEL1310110023#_90aa0dfa_3436_4950_b488_16487a71bdd1
is: F8W1L5
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: GPD1
has only substance units: false
type: Species
is encoded by: hsa:2819
initial concentration: NaN
constant: false

metaM hs deg23 l
type: Species
initial amount: NaN
notes: FORMULA: C31H49NO29S CHARGE: -2
initial concentration: 1.0
name: GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
is: HMDB02704
is: CHEBI:21338

metaM dmhptcrn m
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
boundary condition: false
initial amount: NaN
is: HMDB06320
constant: false
type: Species
name: 2,6 dimethylheptanoyl carnitine
has only substance units: false

metaR SPODM
is described by: ECO:0000269
product: MODEL1310110023#
reactant: MODEL1310110023#
name: superoxide dismutase
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.15.1.1
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
reversible: false
is: SBO:0000176

metaR G12MT1 U
type: Reaction
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110023#
product: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000176
name: Glycolipid 1,2-alpha-D-mannosyltransferase (uterus)
reactant: MODEL1310110023#

metaR FAOXC61C4m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)m
type: Reaction

metaM ksi pre11 g
is: SBO:0000247
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 11
has only substance units: false
notes: FORMULA: C129H208N9O101S3X CHARGE: -4
is: CHEBI:28067
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_8c76dcd9_867d_49ff_a317_3139d76383b7
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: ADH5
is: Q6IRT1
type: Species
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:128

http://identifiers.org/biomodels.db/MODEL1310110023#_2075969a_dbb8_4953_a9a1_b61072b73d83
initial concentration: NaN
name: ATP1B2
constant: false
is: SBO:0000252
is encoded by: hsa:482
is: P14415
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true

metaR FAOXC15ATPx
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C15)x
type: Reaction

metaR r2030
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110023#
reversible: false
is: SBO:0000185
reactant: MODEL1310110023#
modifier: MODEL1310110023#
is described by: ECO:0000000
kinetic law: MODEL1310110023#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_36165037_befe_48e4_9ac7_225eace692bf
has only substance units: false
is: O15254
is: SBO:0000252
constant: false
boundary condition: true
name: ACOX3
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:8310
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_d8d527cd_f2e3_42fd_a21e_d55ddff45cd6
name: NME1:NME2
is encoded by: hsa:4830
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000297
type: Species

metaM 3octpencoa m
name: 3,6,9,12,15-octadecapentenoylcoa
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
initial amount: NaN
is: HMDB02288
type: Species

metaR FAOXTC122m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization trans(C12:2)m
type: Reaction

metaR PHCHGSm
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:taken from KEGG map. No enzyme assigned, so assumed this is a non-enzymatic reaction. NCD
type: Reaction
product: MODEL1310110023#
reactant: MODEL1310110023#
reversible: true
fast: false
is: SBO:0000176
kinetic law: MODEL1310110023#
name: L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110023#_dbe378b8_7d87_46d8_93ab_a5f75084baa0
type: Species
boundary condition: true
is encoded by: hsa:4967
is: Q02218
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: OGDH
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_b87c6d3e_02e5_4006_a81d_a588607bca5f
name: _AA788780_1_c
is: SBO:0000252
is encoded by: hsa:AA788780
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species

metaM ksii core2 pre2 g
has only substance units: false
is: C00130
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00175
is: CHEBI:58053
name: keratan sulfate II biosynthesis, precursor 2
initial amount: NaN
type: Species
notes: FORMULA: C39H63N3O28X CHARGE: -1

metaM thm c
is: SBO:0000247
has only substance units: false
name: Thiamin
is: C00378
notes: FORMULA: C12H17N4OS CHARGE: 1
is: CHEBI:0
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB00235
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_ebda18c5_7259_473a_ac75_22a582c71ab7
has only substance units: false
initial amount: NaN
is: P13995
name: MTHFD2
initial concentration: NaN
type: Species
is encoded by: hsa:10797
boundary condition: true
constant: false
is: SBO:0000252

metaR DCSPTN1t
reactant: MODEL1310110023#
type: Reaction
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
name: fatty acid transport via diffusion
fast: false
kinetic law: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110023#_17b127a0_d765_459a_8ff3_099abc7bd225
type: Species
is encoded by: hsa:6541
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: P30825
name: SLC7A1
has only substance units: false
initial concentration: NaN
constant: false

metaR GGH 6DHFe
is: SBO:0000176
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
kinetic law: MODEL1310110023#
product: MODEL1310110023#
type: Reaction
name: Gamma-glutamyl hydrolase (6DHF), extracellular
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.4.19.9
modifier: MODEL1310110023#
fast: false
reactant: MODEL1310110023#

metaM HC00342 m
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
is: SBO:0000247
name: cis-aconitate(3-)
has only substance units: false
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:16383
initial amount: NaN

metaR 5MTHFt
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
product: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
kinetic law: MODEL1310110023#
is described by: ECO:0000269
reversible: true
fast: false
type: Reaction
is: SBO:0000185
modifier: MODEL1310110023#

metaR r2032
type: Reaction
is: SBO:0000185
modifier: MODEL1310110023#
product: MODEL1310110023#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110023#
reversible: false
fast: false
kinetic law: MODEL1310110023#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110023#_e466e11b_f75d_456a_9f42_9b2c056f1175
has only substance units: false
is: O00219
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:3038
name: HAS3
type: Species
boundary condition: true

metaR r1649
reactant: MODEL1310110023#
is described by: ECO:0000000
kinetic law: MODEL1310110023#
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110023#
type: Reaction
is: SBO:0000185
reversible: true
fast: false

metaR GULNter
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: L-gulonate endoplasmic reticular export
fast: false
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
is: SBO:0000185
product: MODEL1310110023#
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110023#_f9d93c63_2335_4e2f_9a9a_3e1eb93e2e9c
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:57665
is: SBO:0000252
boundary condition: true
constant: false
is: Q9HBH5
type: Species
name: RDH14

metaR EX hestratriol LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4,17 dihydroxy estradiol exchange
type: Reaction

metaR r1435
kinetic law: MODEL1310110023#
product: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110023#
fast: false
name: Transport reaction
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110023#_47004aa5_ce89_4a59_90b7_1fb6dee2e890
is: P61457
boundary condition: true
has only substance units: false
is encoded by: hsa:5092
initial amount: NaN
constant: false
initial concentration: NaN
name: PCBD1
type: Species
is: SBO:0000252

metaR BILIRUBtr
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
type: Reaction
is: SBO:0000185
product: MODEL1310110023#
fast: false
name: lipid, flip-flop intracellular transport
reversible: true
reactant: MODEL1310110023#
is described by: ECO:0000000

metaR RE0958E
name: RE0958
is version of: http://identifiers.org/ec-code/3.2.1.17
kinetic law: MODEL1310110023#
type: Reaction
reactant: MODEL1310110023#
fast: false
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.1
modifier: MODEL1310110023#
product: MODEL1310110023#
reversible: true

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

metaR MMEm
reversible: true
reactant: MODEL1310110023#
product: MODEL1310110023#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/5.1.99.1
notes: GENE_ASSOCIATION: (84693.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.1.99.1 Confidence Level: 4 AUTHORS: PMID:11481338 NOTES:TDV
type: Reaction
name: methylmalonyl-CoA epimerase/racemase
fast: false
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

metaM core3 g
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C16H27N2O10X CHARGE: 0
name: Core 3
is: CHEBI:16250
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaM pail45p hs n
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
initial amount: NaN
is: SBO:0000247
name: phosphatidylinositol 4,5-bisphosphate
type: Species
is: CHEBI:28910
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false

metaM dutp n
is: CHEBI:17625
is: HMDB01191
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
constant: false
boundary condition: false
name: dUTP
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110023#_93c3bb22_c3cb_421a_83a2_37803da3a1e5
is: Q9P0Z9
name: PIPOX
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:51268
has only substance units: false
type: Species
boundary condition: true
constant: false

metaM taur e
is: C00245
constant: false
is: CHEBI:3544
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB00251
notes: FORMULA: C2H7NO3S CHARGE: 0
initial amount: NaN
boundary condition: false
name: Taurine
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_f2b8c6df_9f25_4b13_93b6_5ecc96868811
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is encoded by: hsa:92579
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: G6PC3
is: Q9BUM1

metaR EX eicostet LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: eicosatetranoic acid exchange
type: Reaction

metaR GACPAILter
product: MODEL1310110023#
name: glucosaminyl-acylphosphatidylinositol ER flippase
type: Reaction
reactant: MODEL1310110023#
fast: false
reversible: false
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14517336 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000185

metaR GGH 10FTHF5GLUe
is: SBO:0000176
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.19.9
modifier: MODEL1310110023#
name: Gamma-glutamyl hydrolase (10FTHF5GLU), extracellular
product: MODEL1310110023#
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
type: Reaction
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_abe104f5_b0c5_4480_9f93_7d0713a609d0
name: SYNJ1
is: O43426
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8867
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
constant: false

metaM 7thf e
initial amount: NaN
initial concentration: 1.0
name: heptaglutamyl folate (THF)
boundary condition: false
is: SBO:0000247
is: HMDB06559
notes: FORMULA: C49H57N13O24 CHARGE: -8
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_8fe96f14_80eb_4fe3_95be_b7ba241e8024
is encoded by: hsa:5152
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
constant: false
name: PDE9A
is: SBO:0000252
initial concentration: NaN

metaM dutp m
initial concentration: 1.0
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB01191
initial amount: NaN
name: dUTP
has only substance units: false
constant: false
is: CHEBI:17625

http://identifiers.org/biomodels.db/MODEL1310110023#_e3b44eb9_ea48_4511_8dee_7eca0bc2686c
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:AGPAT7
name: _AGPAT7_1_c

metaM pail45p hs m
has only substance units: false
name: phosphatidylinositol 4,5-bisphosphate
is: CHEBI:28910
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
constant: false

metaR LINKDEG1ly
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
name: degradation of proteoglycan linkage region, lysosomal
product: MODEL1310110023#
type: Reaction
fast: false
kinetic law: MODEL1310110023#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_1875eee8_0788_499b_9a53_01f9d1e18cf6
name: PANK2
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:80025

http://identifiers.org/biomodels.db/MODEL1310110023#_d51a3a21_affe_4f59_9844_418b5b4b8e58
is encoded by: hsa:64077
has only substance units: false
name: LHPP
constant: false
type: Species
is: Q9H008
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaM tetd7ecoa m
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
initial concentration: 1.0
is: SBO:0000247
name: 7-tetradecenoylcoa
is: HMDB13109
boundary condition: false
has only substance units: false

metaR r0191
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110023#
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (7915.1) or (9856.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275,PMID:4276999 NOTES:
reversible: false
name: UTP:D-fructose-6-phosphate 1-phosphotransferase EC:2.7.1.11
is: SBO:0000176
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.2.1.24
reactant: MODEL1310110023#
type: Reaction

metaM biocyt c
is: SBO:0000247
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
initial amount: NaN
has only substance units: false
is: HMDB03134
constant: false
boundary condition: false
initial concentration: 1.0
is: C05552
is: http://identifiers.org/pubchem.compound/7886
name: Biocytin
type: Species

metaM xmp c
notes: FORMULA: C10H11N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00478 EHMN_ABBREVIATION: C00655
type: Species
initial amount: NaN
is: CHEBI:57464
boundary condition: false
has only substance units: false
is: C00655
is: SBO:0000247
initial concentration: 1.0
constant: false
name: Xanthosine 5'-phosphate
is: HMDB01554

http://identifiers.org/biomodels.db/MODEL1310110023#_90228e67_ec6f_4e72_b274_ac9be71e0106
constant: false
initial concentration: NaN
is: O75874
is encoded by: hsa:3417
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
name: IDH1

metaM HC01361 e
is: CHEBI:17001
notes: FORMULA: C9H13N5O4 CHARGE: 0 INCHI: InChI=1S/C9H13N5O4/c10-9-13-7-5(8(18)14-9)12-3(1-11-7)6(17)4(16)2-15/h4,6,15-17H,1-2H2,(H4,10,11,13,14,18)/t4-,6+/m1/s1 EHMN_ABBREVIATION: C04874
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
name: Dihydroneopterin
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110023#_c46d709e_7a3d_41c5_b40a_f39892b96f09
boundary condition: true
has only substance units: false
is: P50747
is encoded by: hsa:3141
type: Species
constant: false
initial amount: NaN
name: HLCS
initial concentration: NaN
is: SBO:0000252

metaM orot c
is: HMDB00226
is: CHEBI:30839
type: Species
name: Orotate
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: C00295
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110023#_1901f7c0_84e6_48a7_811a_27603fff9a10
name: GNPDA1
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10007
type: Species
is: P46926
initial concentration: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_e5abf79c_0777_4822_9523_6e7be2ab799c
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: E9PHN8
is encoded by: hsa:9843
type: Species
name: HEPH
boundary condition: true

metaM lnlncgcoa r
initial concentration: 1.0
constant: false
is: HMDB06368
type: Species
name: gamma-linolenoyl-CoA(4-)
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
initial amount: NaN
is: CHEBI:57363

http://identifiers.org/biomodels.db/MODEL1310110023#_5bc98769_1670_4440_b54d_7f46a036b3c1
name: SLC29A2
boundary condition: true
is encoded by: hsa:3177
is: SBO:0000252
is: Q14542
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
has only substance units: false

metaM glc D r
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: CHEBI:4167
has only substance units: false
name: D-glucose
initial concentration: 1.0
is: HMDB00122
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_5e46fe1c_6a64_483c_8d94_96763fd37708
is: Q7GXZ4
has only substance units: false
name: ND4L
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:4539

metaR NACHEXA12ly
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
reactant: MODEL1310110023#
fast: false
type: Reaction
reversible: false
product: MODEL1310110023#
name: beta-N-acetylhexosaminidase A, lysosomal
modifier: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_e0fce40d_1f8d_4564_bcd9_c925950efa1f
initial amount: NaN
is: F8WAB8
is: SBO:0000252
is encoded by: hsa:115286
boundary condition: true
initial concentration: NaN
type: Species
constant: false
name: SLC25A26
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_5ac9aff1_44db_4cf8_98c1_36121b41a5dd
boundary condition: true
type: Species
is: SBO:0000252
name: _AI620219_1_m
is encoded by: hsa:AI620219
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_2621bdfa_e4b0_4d06_836f_d0174a806a9b
type: Species
is: O43772
constant: false
is encoded by: hsa:788
has only substance units: false
name: SLC25A20
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110023#_11fd1a94_297d_4c58_b449_3e5195a9e2b1
type: Species
constant: false
is encoded by: hsa:81537
initial amount: NaN
is: SBO:0000252
is: Q9BX95
has only substance units: false
initial concentration: NaN
boundary condition: true
name: SGPP1

metaM 5dpmev c
is: HMDB01090
is: SBO:0000247
constant: false
name: (R)-5-Diphosphomevalonate
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1

metaM 13dpg c
name: 3-Phospho-D-glyceroyl phosphate
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
constant: false
initial amount: NaN
has only substance units: false
is: C00236
is: http://identifiers.org/pubchem.compound/3535
type: Species
is: HMDB01270
is: SBO:0000247
boundary condition: false
is: CHEBI:57604
initial concentration: 1.0

metaM pail hs n
has only substance units: false
is: CHEBI:57880
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
name: 1-phosphatidyl-1D-myo-inositol(1-)
is: SBO:0000247
constant: false
type: Species
initial amount: NaN

metaM ocdcea e
boundary condition: false
is: C00712
is: HMDB00207
name: octadecenoate (n-C18:1)
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C18H33O2 CHARGE: -1
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:0

metaR FAOXC184C163x
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:3)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_a9633ddf_98c7_4f1e_a5af_95e929f87e80
boundary condition: true
is encoded by: hsa:4712
is: SBO:0000252
type: Species
initial concentration: NaN
name: NDUFB6
constant: false
has only substance units: false
is: O95139
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_6593c1ca_e8af_4993_9588_bcd59d4cbf2c
type: Species
constant: false
is: P30613
initial amount: NaN
name: PKLR
is encoded by: hsa:5313
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaM prostgd2 r
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
type: Species
has only substance units: false
initial concentration: 1.0
name: prostaglandin D2(1-)
boundary condition: false
initial amount: NaN
is: HMDB01403
is: CHEBI:57406
constant: false

metaR DHPM1
type: Reaction
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
reversible: false
fast: false
product: MODEL1310110023#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:
is version of: http://identifiers.org/ec-code/3.5.2.2
modifier: MODEL1310110023#
name: dihydropyrimidinase (5,6-dihydrouracil)

metaM icit c
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
constant: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
is: C00311
is: CHEBI:16087
name: Isocitrate
is: HMDB00193

metaM pppg9 c
notes: FORMULA: C34H38N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00656 EHMN_ABBREVIATION: C01079
constant: false
name: Protoporphyrinogen IX
boundary condition: false
is: C01079
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57307
has only substance units: false
is: HMDB01097
type: Species

metaR RE3556C
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
product: MODEL1310110023#
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
is described by: ECO:0000000
name: RE3556
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_e5c1169c_43d6_4e9d_a4fc_73c866269174
is encoded by: hsa:51703
name: ACSL5
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: Q9ULC5
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110023#_1a174842_835d_4e1f_b86b_e33e4599c985
initial amount: NaN
type: Species
boundary condition: true
is: Q92535
name: PIGC
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5279

metaR CHOLtu
reactant: MODEL1310110023#
type: Reaction
is: SBO:0000185
name: Choline uniport
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110023#
product: MODEL1310110023#
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
fast: false

metaM 1p3h5c c
is: SBO:0000247
constant: false
is: HMDB01369
has only substance units: false
initial amount: NaN
boundary condition: false
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
type: Species
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
initial concentration: 1.0
is: CHEBI:6151

metaR DHPM2
is: SBO:0000176
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 2 AUTHORS: NOTES:Also acts on dihydrothymine and hydantoin. Found not specific evidence in PubMed, but Dihydropyrimidinase is supposed to be in cytosol and catalyze this reaction. Old information
is described by: ECO:0000000
reactant: MODEL1310110023#
reversible: false
fast: false
type: Reaction
name: dihydropyrimidinase (dihydrothymine)
product: MODEL1310110023#

metaR S6TASE22ly
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110023#
product: MODEL1310110023#
name: galactose-6-sulfate sulfatase, lysosomal
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110023#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: true
type: Reaction

metaR LSTO2r
name: Lathosterol oxidase
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
is version of: http://identifiers.org/ec-code/1.14.21.6
type: Reaction
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
product: MODEL1310110023#
is: SBO:0000176
is described by: ECO:0000269
fast: false
reactant: MODEL1310110023#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110023#_f0bc4524_f1a2_4de9_b0fe_79fc033702c1
type: Species
is: B4E0V8
has only substance units: false
initial amount: NaN
name: HAL
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:3034
boundary condition: true

metaM ocdcea l
constant: false
initial amount: NaN
is: SBO:0000247
is: HMDB00207
boundary condition: false
has only substance units: false
name: oleate
is: CHEBI:30823
type: Species
initial concentration: 1.0
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9- HEPATONET_1.0_ABBREVIATION: HC00510 EHMN_ABBREVIATION: C00712

http://identifiers.org/biomodels.db/MODEL1310110023#_d5643b9c_e965_4b06_a4d7_48d0aae5757d
boundary condition: true
name: GAL3ST1
initial concentration: NaN
is encoded by: hsa:9514
constant: false
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: Q99999

metaM tetdecdicoa x
has only substance units: false
is: HMDB02288
is: SBO:0000247
name: 5,8-tetradecadienoylcoa
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
initial concentration: 1.0
constant: false

metaM dmhptcrn e
constant: false
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: 2,6 dimethylheptanoyl carnitine
is: HMDB06320
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3

http://identifiers.org/biomodels.db/MODEL1310110023#_3d41a615_a0b2_4da6_a103_f9e6174f16fa
is: SBO:0000252
is: Q9NYR8
type: Species
is encoded by: hsa:50700
name: RDH8
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR FMNAT
is version of: http://identifiers.org/ec-code/2.7.7.2
product: MODEL1310110023#
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
name: FMN adenylyltransferase
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110023#
is described by: ECO:0000134
fast: false
reversible: false
reactant: MODEL1310110023#

metaR GLYt7 311 r
is: SBO:0000185
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
fast: false
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
name: glycine reversible transport via sodium and chloride symport (3:1:1)
type: Reaction
reversible: true
is described by: ECO:0000006
product: MODEL1310110023#

metaR RE2974N
fast: false
is described by: ECO:0000000
reactant: MODEL1310110023#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:
kinetic law: MODEL1310110023#
type: Reaction
reversible: true
product: MODEL1310110023#
name: RE2974

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_025dc54f_4ae0_49a5_95c6_892274e667f7
initial concentration: NaN
boundary condition: true
name: AK4
is encoded by: hsa:205
is: SBO:0000252
type: Species
initial amount: NaN
is: P27144
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_1fb6e850_8e59_4dec_baaf_35184a58a765
has part: Q8TBF5
type: Species
name: PIGX:PIGM
initial concentration: NaN
constant: false
is encoded by: hsa:93183
boundary condition: true
initial amount: NaN
is: SBO:0000297
has only substance units: false
is encoded by: hsa:54965
has part: Q9H3S5

http://identifiers.org/biomodels.db/MODEL1310110023#_4b686667_d84f_4d2b_bb4f_c423e40bf980
boundary condition: true
name: FOLR3
constant: false
has only substance units: false
is encoded by: hsa:2352
is: Q05C14
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species

metaR FAOXC18480m
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 4 degrees loss of saturation -> only 1 fad oxidized to fadh2 peroxisomal (very long chain FA) c18:4,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176
is described by: ECO:0000000
name: Beta oxidation of fatty acid
type: Reaction
reactant: MODEL1310110023#
modifier: MODEL1310110023#
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
kinetic law: MODEL1310110023#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3

metaR EX HC02202 LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin A1(1-) exchange
type: Reaction

metaR r0193
type: Reaction
reactant: MODEL1310110023#
is described by: ECO:0000000
kinetic law: MODEL1310110023#
reversible: true
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
is: SBO:0000176
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
fast: false

metaR UGLCNACtg
is described by: ECO:0000269
name: UDP-GlcNAc Golgi transport via CMP antiport
is: SBO:0000185
reactant: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD
modifier: MODEL1310110023#
product: MODEL1310110023#
type: Reaction
kinetic law: MODEL1310110023#
reversible: true

metaM acgam1p c
is: HMDB01367
is: SBO:0000247
has only substance units: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01256 EHMN_ABBREVIATION: C04256
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:7125
constant: false
name: N-Acetyl-D-glucosamine 1-phosphate

http://identifiers.org/biomodels.db/MODEL1310110023#_14422eb0_628f_4b0a_b47a_4c4d8a81b67a
constant: false
boundary condition: true
is: Q13454
initial concentration: NaN
name: TUSC3
is encoded by: hsa:7991
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species

metaM ethamp c
boundary condition: false
is: HMDB00224
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:58190
name: ethamp[c]
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_d90a73e9_4027_4c3f_b1d1_be6536548118
boundary condition: true
initial concentration: NaN
type: Species
is: P37837
is encoded by: hsa:6888
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
name: TALDO1

http://identifiers.org/biomodels.db/MODEL1310110023#_222957ff_2863_4f62_8e11_1749c46d6242
type: Species
name: AMPD3
is: B7Z763
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:272
initial concentration: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110023#_4f4390a6_bb83_4064_a7f7_7b078fe234fd
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:26503
name: SLC17A5
is: Q9NRA2
has only substance units: false

metaM dmhptcrn c
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
type: Species
name: 2,6 dimethylheptanoyl carnitine
initial concentration: 1.0
is: SBO:0000247
is: HMDB06320
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_1229b122_b398_4fa9_9c0c_3a90fd95e889
type: Species
initial concentration: NaN
is encoded by: hsa:7083
has only substance units: false
name: TK1
boundary condition: true
constant: false
is: P04183
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110023#_af5383de_8e92_4355_94f8_2de206851ca1
type: Species
constant: false
is: SBO:0000252
boundary condition: true
name: GAD2
is: Q5VZ30
is encoded by: hsa:2572
has only substance units: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_1a0a80d9_211e_452a_a902_a938bb01b3fb
is encoded by: hsa:3074
constant: false
boundary condition: true
name: HEXB
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: P07686
type: Species

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_d9df0228_5d53_43f7_bd7e_47c865ff2895
is encoded by: hsa:6561
is: Q9BZW2
type: Species
is: SBO:0000252
initial amount: NaN
name: SLC13A1
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_5b9dfaae_5431_465f_95d5_cc071b550b9f
initial amount: NaN
is encoded by: hsa:10568
name: SLC34A2
has only substance units: false
constant: false
boundary condition: true
type: Species
initial concentration: NaN
is: O95436
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110023#_654a9739_eab9_47fe_9113_0cf03faad45f
type: Species
is encoded by: hsa:9380
is: SBO:0000252
initial concentration: NaN
is: Q9UBQ7
boundary condition: true
name: GRHPR
constant: false
initial amount: NaN
has only substance units: false

metaR NDPK5n
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110023#
fast: false
reversible: true
product: MODEL1310110023#
is: SBO:0000176
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
modifier: MODEL1310110023#
type: Reaction
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110023#_e3c52d94_3ef6_4d4a_923d_d24b80f63a6a
name: PIP4K2A
is: P48426
has only substance units: false
is encoded by: hsa:5305
is: SBO:0000252
type: Species
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_5ac28bc7_930c_4095_b65e_7b722f3088e8
name: NPR1
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
is: P16066
is encoded by: hsa:4881

metaR SCPx
type: Reaction
name: peroxisomal thiolase 2
is version of: http://identifiers.org/ec-code/2.3.1.176
reversible: false
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways NJ
modifier: MODEL1310110023#
reactant: MODEL1310110023#
is: SBO:0000176
fast: false
product: MODEL1310110023#
is described by: ECO:0000269
kinetic law: MODEL1310110023#

metaR r0472
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
product: MODEL1310110023#
is described by: ECO:0000000
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110023#_95a14c37_4bca_433d_99ee_3ff2c6009381
has only substance units: false
is: P30838
initial amount: NaN
is encoded by: hsa:218
constant: false
boundary condition: true
initial concentration: NaN
name: ALDH3A1
is: SBO:0000252
type: Species

metaR GLUDC
modifier: MODEL1310110023#
product: MODEL1310110023#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.15
is: SBO:0000176
reactant: MODEL1310110023#
name: Glutamate Decarboxylase
type: Reaction
notes: GENE_ASSOCIATION: (2571.1) or (2572.1) or (2571.2) SUBSYSTEM: Glutamate metabolism EC Number: 4.1.1.15 Confidence Level: 4 AUTHORS: PMID:1924293,PMID:8088791 NOTES:JLR- added h to balance
kinetic law: MODEL1310110023#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110023#_ba220f33_7964_42df_9d64_18754a6efa33
initial concentration: NaN
is encoded by: hsa:10449
is: SBO:0000252
has only substance units: false
is: P42765
type: Species
boundary condition: true
constant: false
name: ACAA2
initial amount: NaN

metaM dhap e
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
initial amount: NaN
is: HMDB01473
has only substance units: false
name: glycerone phosphate(2-)
is: SBO:0000247
is: CHEBI:57642
type: Species
constant: false

metaM CE5586 c
name: N-[(E)-4-ammoniobutylidene]propane-1,3-diaminium
boundary condition: false
is: CHEBI:58732
constant: false
type: Species
has only substance units: false
notes: FORMULA: C7H20N3 CHARGE: 3 INCHI: InChI=1S/C7H17N3/c8-4-1-2-6-10-7-3-5-9/h6H,1-5,7-9H2/p+3/b10-6+ EHMN_ABBREVIATION: CE5586
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR EX gsn LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Guanosine
type: Reaction

metaR r1554
type: Reaction
product: MODEL1310110023#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false

metaM estradiol r
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
is: HMDB00151
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
is: SBO:0000247
is: CHEBI:16469
name: estradiol

http://identifiers.org/biomodels.db/MODEL1310110023#_fdaec53c_05ef_47f2_9bdd_ac8808c9b419
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is: P04075
initial concentration: NaN
is encoded by: hsa:226
name: ALDOA
type: Species

metaR FAOXC184C163m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C18:4-->C16:3)m
type: Reaction

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

metaR S6T16g
fast: false
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110023#
reactant: MODEL1310110023#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110023#

metaR AG13T8g
is: SBO:0000176
product: MODEL1310110023#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
reversible: false
modifier: MODEL1310110023#
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus

metaR HPACtr
fast: false
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
reactant: MODEL1310110023#
is described by: ECO:0000000
type: Reaction
name: hydroxyphenylacetate transport via diffusion
product: MODEL1310110023#

metaM 1p3h5c m
boundary condition: false
is: CHEBI:6151
has only substance units: false
type: Species
is: SBO:0000247
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
initial concentration: 1.0
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
constant: false
is: HMDB01369
initial amount: NaN

metaR ACETONEt2
reversible: true
modifier: MODEL1310110023#
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
kinetic law: MODEL1310110023#
is: SBO:0000185
name: acetone transport via proton symport
type: Reaction
reactant: MODEL1310110023#
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110023#_dc55c0cf_1d70_4740_a718_dbfa763b3793
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
name: SLC2A8
is: Q9NY64
type: Species
is encoded by: hsa:29988
is: SBO:0000252

metaR FAOXC2051843m
name: Beta oxidation of fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110023#
is: SBO:0000176
reversible: false
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000000
type: Reaction

metaR FACOAL181i
name: C181 fatty acid activation
notes: GENE_ASSOCIATION: (2180.1) or (2181.2) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110023#
is described by: ECO:0000269
reversible: false
fast: false
product: MODEL1310110023#
reactant: MODEL1310110023#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110023#

metaR CRNrtx
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: added during gap filling. NOTES:added during gap filling.
name: reversible transport of L-Carnitine in peroxisome
reversible: true
product: MODEL1310110023#
is: SBO:0000185
type: Reaction
fast: false

metaM cs e deg4 l
boundary condition: false
constant: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 4
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00127
initial amount: NaN
is: SBO:0000247
is: CHEBI:15748
notes: FORMULA: C31H46NO38S4 CHARGE: -5

metaR FACOAL206
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: true
is described by: ECO:0000269
name: fatty-acid--CoA ligase
modifier: MODEL1310110023#
fast: false
type: Reaction
product: MODEL1310110023#
kinetic law: MODEL1310110023#

metaR r0474
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
product: MODEL1310110023#
kinetic law: MODEL1310110023#
fast: false
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110023#

metaR KYNAKGAT
type: Reaction
product: MODEL1310110023#
reactant: MODEL1310110023#
name: L-Kynurenine:2-oxoglutarate aminotransferase
is version of: http://identifiers.org/ec-code/2.6.1.7
modifier: MODEL1310110023#
reversible: false
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.64
kinetic law: MODEL1310110023#

metaM dhap c
is: C00111
initial concentration: 1.0
name: Dihydroxyacetone phosphate
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
is: HMDB01473
is: http://identifiers.org/pubchem.compound/3411
is: SBO:0000247
is: CHEBI:57642
type: Species

metaR PEROXx
notes: GENE_ASSOCIATION: (3295.1 and 8310.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:lumped peroxisomal alpha and beta oxidation pristanoyl-CoA -> 4,8 diemthylnonanoyl-CoA (result of compound not known) stoichiometry for O2 is questionable at present no fad in peroxisome - 1st step of beta ox is acyl-co oxidase (not reductase) NJ
fast: false
reactant: MODEL1310110023#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
product: MODEL1310110023#
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/4.2.1.107
name: peroxisomal lumped long chain fatty acid oxidation
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110023#
is described by: ECO:0000000

metaR r1552
fast: false
product: MODEL1310110023#
kinetic law: MODEL1310110023#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110023#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR CHOLtn
is: SBO:0000185
reversible: true
name: Choline transport, nuclear through pores
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110023#
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_ef0a9629_cfb1_4658_95d4_b48647b2230f
initial concentration: NaN
initial amount: NaN
is: Q4KWH8
has only substance units: false
name: PLCH1
boundary condition: true
constant: false
is encoded by: hsa:23007
type: Species
is: SBO:0000252

metaM pmtcrn c
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17490
is: SBO:0000247
boundary condition: false
name: L-palmitoylcarnitine
type: Species
constant: false
is: HMDB00222
has only substance units: false

metaR FACOAL204
name: fatty-acid--CoA ligase
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT
reactant: MODEL1310110023#
fast: false
kinetic law: MODEL1310110023#
type: Reaction
modifier: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_d84af10c_d3c8_4672_8629_158fcf26f797
initial concentration: NaN
name: B3GNT2
constant: false
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:10678
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_ca87739d_4728_48b6_b493_e6bf2ba91195
is encoded by: hsa:11182
has only substance units: false
constant: false
name: SLC2A6
is: SBO:0000252
initial concentration: NaN
type: Species
is: Q9UGQ3
initial amount: NaN
boundary condition: true

metaM ksi pre4 g
initial concentration: 1.0
is: CHEBI:58053
type: Species
is: C00130
has only substance units: false
notes: FORMULA: C101H165N7O72X CHARGE: -1
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB00175
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 4

metaR 2AMACSULT
fast: false
type: Reaction
is: SBO:0000176
reversible: false
is described by: ECO:0000000
product: MODEL1310110023#
kinetic law: MODEL1310110023#
name: 2-Aminoacrylate sulfotransferase
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220,PMID:6351723 NOTES:-this is a lumped rxn w/ an inferred reduction rxn that occurs in conjunction w/ sulfotransferase step; this reduction step has to occur in order for the transformation (2amac-->Lcyst) to be valid -used NADPH as electron donor since it is a common cofactor involved in biosynthetic steps utilizing oxygen (see Neema for further explanations) MM
reactant: MODEL1310110023#

metaR PIPLC
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (23007.1) or (113026.1) or (89869.1) or (84812.1) or (9651.1) or (5335.1) or (51196.1) or (257068.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (5330.1) or (23236.1) or (5333.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
is described by: ECO:0000000
type: Reaction
name: phosphatidylinositol phospholipase C
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.4.11
fast: false
is: SBO:0000176
reactant: MODEL1310110023#

metaR r1553
is: SBO:0000185
kinetic law: MODEL1310110023#
reversible: true
reactant: MODEL1310110023#
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110023#

metaM dcsptn1coa x
type: Species
is: http://identifiers.org/pubchem.compound/47205483
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
initial amount: NaN
is: C16173
has only substance units: false
constant: false
is: HMDB06513
boundary condition: false
initial concentration: 1.0
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
is: SBO:0000247

metaR GLYt7 211 r
modifier: MODEL1310110023#
is described by: ECO:0000269
product: MODEL1310110023#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
reversible: true
name: glycine reversible transport via sodium and chloride symport (2:1:1)
fast: false

metaR Coqe
is: SBO:0000185
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
name: Transport of q10
kinetic law: MODEL1310110023#
reversible: true
reactant: MODEL1310110023#
product: MODEL1310110023#

metaR RE1233C
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.6.1.64
name: RE1233
is: SBO:0000176
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reversible: true
type: Reaction
reactant: MODEL1310110023#

metaM cs e deg1 l
boundary condition: false
has only substance units: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 1
is: CHEBI:57737
type: Species
initial amount: NaN
is: HMDB00868
is: SBO:0000247
constant: false
notes: FORMULA: C45H65N2O52S5 CHARGE: -7
initial concentration: 1.0

metaM HC01610 e
is: CHEBI:28607
is: SBO:0000247
constant: false
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
name: CoproporphyrinogenI
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_d939cb9a_1658_4f5d_ae86_1b221aa81b21
is: Q92604
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:9926
name: LPGAT1
initial amount: NaN
is: SBO:0000252

metaR TXASr
modifier: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (6916.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.5 Confidence Level: 0 AUTHORS: PMID:10903770,PMID:2491846,PMID:7811713 NOTES:NJ
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/5.3.99.5
is: SBO:0000176
product: MODEL1310110023#
name: Thromboxane-A synthase
is described by: ECO:0000134
reversible: false
kinetic law: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_a6a3bda3_80c3_4388_add0_5afa3edcf9a5
has only substance units: false
is: SBO:0000252
is: Q9UJS0
constant: false
name: SLC25A13
is encoded by: hsa:10165
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaM ocdcea c
initial concentration: 1.0
is: CHEBI:0
boundary condition: false
constant: false
is: HMDB00207
initial amount: NaN
has only substance units: false
notes: FORMULA: C18H33O2 CHARGE: -1
type: Species
name: octadecenoate (n-C18:1)
is: SBO:0000247
is: C00712

metaR GLCAASE4ly
reversible: false
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.31
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
name: beta-glucuronidase, lysosomal
kinetic law: MODEL1310110023#
fast: false
is: SBO:0000176
type: Reaction

metaM phyt e
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB00801
is: CHEBI:37257
has only substance units: false
type: Species
name: phytanate
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607

http://identifiers.org/biomodels.db/MODEL1310110023#_70faf75a_816d_4f76_84e3_1a386334b7d7
is encoded by: hsa:8706
has only substance units: false
initial concentration: NaN
is: Q8TDY1
constant: false
initial amount: NaN
type: Species
boundary condition: true
name: B3GALNT1
is: SBO:0000252

metaR CYTK3n
is: SBO:0000176
reactant: MODEL1310110023#
reversible: true
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110023#
name: cytidylate kinase (dCMP,CTP),nuclear
is described by: ECO:0000269
modifier: MODEL1310110023#

metaR r1551
reactant: MODEL1310110023#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110023#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

metaR ASNtN1
fast: false
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
product: MODEL1310110023#
kinetic law: MODEL1310110023#
type: Reaction
name: Asparagine transport (Na, H coupled)
is: SBO:0000185
reactant: MODEL1310110023#
modifier: MODEL1310110023#
reversible: true
is described by: ECO:0000269

metaM spc hs c
is: http://identifiers.org/pubchem.compound/5311445
has only substance units: false
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
name: sphingosylphosphorylcholine

metaM prgstrn e
type: Species
notes: FORMULA: C21H30O2 CHARGE: 0 INCHI: InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C00410
initial concentration: 1.0
is: CHEBI:17026
is: SBO:0000247
is: HMDB01830
name: progesterone
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_d8dc67fe_fdb9_4d9f_842f_1dfca50fc921
name: ATP1A3:ATP1B2
is encoded by: hsa:482
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000297
constant: false
has part: P14415

metaR r0475
is: SBO:0000176
product: MODEL1310110023#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reactant: MODEL1310110023#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
is described by: ECO:0000000
kinetic law: MODEL1310110023#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_2e313002_08da_4ec1_85af_60be4c1210f3
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is: Q9NWU1
initial concentration: NaN
is encoded by: hsa:54995
constant: false
is: SBO:0000252
name: OXSM

http://identifiers.org/biomodels.db/MODEL1310110023#_0b36e3c3_8247_470e_a9c8_74b4eab42e0b
is encoded by: hsa:11001
name: SLC27A2
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is: O14975
boundary condition: true

metaR 3MOPte
is: SBO:0000185
fast: false
product: MODEL1310110023#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
name: Transport of 3-methyl-2-oxopentanoate
is described by: ECO:0000134
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_aea59c07_e0a4_4eab_b3cc_fa38be562892
initial concentration: NaN
name: DGKH
boundary condition: true
constant: false
is: Q86XP1
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:160851
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_0c293f59_6207_4ae5_bee1_754a5188a5da
has only substance units: false
is: P36021
name: SLC16A2
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6567
constant: false

metaM dadp n
initial amount: NaN
constant: false
is: HMDB01508
initial concentration: 1.0
name: dADP(3-)
is: CHEBI:57667
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206

metaR FAOXC226C205m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C20:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_b9a242b7_17a1_45a8_a57f_cc9b292b6fcb
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
name: RDH10
is encoded by: hsa:157506
type: Species
initial amount: NaN
is: Q8IZV5

metaM lnlncgcoa m
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
initial concentration: 1.0
name: gamma-linolenoyl-CoA(4-)
is: CHEBI:57363
constant: false
is: HMDB06368

metaR RE3272N
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
type: Reaction
product: MODEL1310110023#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110023#
name: RE3272
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110023#

metaM CE1944 c
name: 1-pyrrolinium
is: CHEBI:36781
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C4H8N CHARGE: 1 INCHI: InChI=1S/C4H7N/c1-2-4-5-3-1/h3H,1-2,4H2/p+1 EHMN_ABBREVIATION: CE1944
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110023#_44e2abb6_1b50_4be2_82cb_5f85aebc46b2
type: Species
has only substance units: false
initial amount: NaN
is: G5E9C5
is encoded by: hsa:8654
name: PDE5A
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true

metaM spc hs e
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
constant: false
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
boundary condition: false
initial concentration: 1.0
name: sphingosylphosphorylcholine
is: http://identifiers.org/pubchem.compound/5311445

http://identifiers.org/biomodels.db/MODEL1310110023#_c10ee642_7e19_4877_a651_23fce72dbe98
is: SBO:0000252
is encoded by: hsa:4725
boundary condition: true
type: Species
constant: false
is: Q6IBA0
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: NDUFS5

metaR RE3005M
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110023#
name: RE3005
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
reactant: MODEL1310110023#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
kinetic law: MODEL1310110023#
product: MODEL1310110023#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_578ddee6_8c36_4d40_b545_89699ecf9239
constant: false
is: SBO:0000252
is: Q14442
has only substance units: false
is encoded by: hsa:5283
name: PIGH
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN

metaR UREAt5
kinetic law: MODEL1310110023#
is: SBO:0000185
reactant: MODEL1310110023#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110023#
product: MODEL1310110023#
reversible: true
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:NCD
fast: false
name: urea, water cotransport

metaM ksi pre25 g
initial concentration: 1.0
is: HMDB00175
notes: FORMULA: C199H319N14O163S7X CHARGE: -8
has only substance units: false
is: C00130
name: keratan sulfate I biosynthesis, precursor 25
initial amount: NaN
is: SBO:0000247
is: CHEBI:58053
boundary condition: false
type: Species
constant: false

metaM HC01407 m
initial amount: NaN
is: CHEBI:28276
type: Species
has only substance units: false
is: SBO:0000247
constant: false
name: (S)-Hydroxyhexanoyl-CoA
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268

metaM dadp m
initial concentration: 1.0
has only substance units: false
name: dADP(3-)
initial amount: NaN
constant: false
boundary condition: false
is: HMDB01508
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: CHEBI:57667
is: SBO:0000247
type: Species

metaR FAOXC80
fast: false
product: MODEL1310110023#
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TDV (9/7/2004) Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
reactant: MODEL1310110023#
modifier: MODEL1310110023#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
is described by: ECO:0000269
name: Beta oxidation of med/long chain fatty acid
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110023#_3484458e_fc56_416c_9ebc_c0e111925ab3
is: SBO:0000252
is encoded by: hsa:10723
initial amount: NaN
constant: false
is: Q9Y666
name: SLC12A7
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species

metaM pail45p hs c
initial amount: NaN
type: Species
name: phosphatidylinositol 4,5-bisphosphate
initial concentration: 1.0
is: CHEBI:28910
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110023#_ca3a0007_8d3c_4d7a_a2e0_2957614a7d57
is encoded by: hsa:91734
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
has only substance units: false
name: IDI2
boundary condition: true
is: Q9BXS1

metaM bilglcur e
is: SBO:0000247
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
is: CHEBI:57767
initial amount: NaN
has only substance units: false
name: mono(glucosyluronic acid)bilirubin(2-)

metaM lnlncgcoa c
is: CHEBI:57363
type: Species
is: HMDB06368
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: SBO:0000247
name: gamma-linolenoyl-CoA(4-)
has only substance units: false
constant: false

metaM udpgal g
type: Species
boundary condition: false
is: SBO:0000247
name: UDP-D-galactose(2-)
initial amount: NaN
is: HMDB00302
constant: false
is: CHEBI:58439
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052

metaR ACONTm
reactant: MODEL1310110023#
product: MODEL1310110023#
reversible: true
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical
kinetic law: MODEL1310110023#
is described by: ECO:0000134
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/4.2.1.3
name: Aconitate hydratase

metaM ksii core4 pre7 g
is: SBO:0000247
notes: FORMULA: C75H121N6O56SX CHARGE: -2
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:58053
initial amount: NaN
is: C00130
name: keratan sulfate II biosynthesis, precursor 7
is: HMDB00175
constant: false

metaM mercppyr c
boundary condition: false
notes: FORMULA: C3H3O3S CHARGE: -1 INCHI: InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00600 EHMN_ABBREVIATION: C00957
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB01368
is: CHEBI:57678
initial amount: NaN
initial concentration: 1.0
constant: false
name: 3-mercaptopyruvate

metaR r0033
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
modifier: MODEL1310110023#
is: SBO:0000176
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
is version of: http://identifiers.org/ec-code/3.6.1.5
reactant: MODEL1310110023#
product: MODEL1310110023#
fast: false
kinetic law: MODEL1310110023#
type: Reaction
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110023#_d5c5865b_a1cf_4d8a_99e3_064b0e9998ca
constant: false
is: O43272
name: PRODH
is encoded by: hsa:5625
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN

metaR INSTt4
reversible: true
fast: false
reactant: MODEL1310110023#
name: inositol transport via sodium symport
type: Reaction
product: MODEL1310110023#
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD
is described by: ECO:0000269
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110023#_e4eb870e_86fc_43f4_819d_347c59c98784
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3251
type: Species
boundary condition: true
name: HPRT1
is: P00492
constant: false
has only substance units: false

metaM pchol hs e
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
is: CHEBI:16110
initial amount: NaN
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
name: Phosphatidylcholine
has only substance units: false

metaR r1632
reactant: MODEL1310110023#
type: Reaction
modifier: MODEL1310110023#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110023#
reversible: true
fast: false
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185

metaR ILEtec
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110023#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
product: MODEL1310110023#
reactant: MODEL1310110023#
name: L-isoleucine transport via diffusion (extracellular to cytosol)
is: SBO:0000185
modifier: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_5a39ae28_1106_4b95_b1be_fd2ac39f3e9c
initial amount: NaN
has only substance units: false
is: Q16773
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:883
boundary condition: true
name: CCBL1
constant: false

metaM trp L c
has only substance units: false
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
type: Species
is: CHEBI:16828
initial concentration: 1.0
constant: false
name: L-tryptophan
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB00929

metaM bilirub r
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
name: bilirubin(2-)
is: CHEBI:57977
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB00054

metaM ksi deg6 l
initial amount: NaN
has only substance units: false
constant: false
type: Species
name: keratan sulfate I, degradation product 6
initial concentration: 1.0
is: HMDB00143
is: CHEBI:12936
boundary condition: false
notes: FORMULA: C210H336N15O184S11 CHARGE: -11
is: SBO:0000247

metaR r1631
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110023#
is: SBO:0000185
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110023#

metaR CDIPTr
kinetic law: MODEL1310110023#
name: phosphatidylinositol synthase (Homo sapiens)
is described by: ECO:0000000
reactant: MODEL1310110023#
product: MODEL1310110023#
modifier: MODEL1310110023#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD
is version of: http://identifiers.org/ec-code/2.7.8.11
reversible: true
type: Reaction

metaM ksi pre34 g
notes: FORMULA: C241H385N17O202S10X CHARGE: -11
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:58053
initial concentration: 1.0
is: HMDB00175
has only substance units: false
is: C00130
type: Species
name: keratan sulfate I biosynthesis, precursor 34
constant: false

metaR MI13PP
reactant: MODEL1310110023#
product: MODEL1310110023#
fast: false
kinetic law: MODEL1310110023#
is: SBO:0000176
name: inositol-1,3-bisphosphate 3-phosphatase
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.64 Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
is described by: ECO:0000000
type: Reaction

metaR ECOAH1m
modifier: MODEL1310110023#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
fast: false
reactant: MODEL1310110023#
is: SBO:0000176
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
kinetic law: MODEL1310110023#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.18
product: MODEL1310110023#
is described by: ECO:0000304

metaM ksii core2 e
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:17268
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
is: HMDB00211
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
name: keratan sulfate II (core 2-linked)

http://identifiers.org/biomodels.db/MODEL1310110023#_25495198_2b4a_4255_a45c_c1376cf36406
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:124454
name: EARS2
is: Q5JPH6
initial amount: NaN

metaM dadp c
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
has only substance units: false
type: Species
initial concentration: 1.0
name: dADP
boundary condition: false
is: CHEBI:57667
is: HMDB01508
initial amount: NaN
is: C00206
is: SBO:0000247
constant: false

metaM triodthy e
constant: false
is: SBO:0000247
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
boundary condition: false
initial concentration: 1.0
is: CHEBI:18258
name: 3,3',5-triiodo-L-thyronine
is: HMDB00265
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_03b07653_bd24_41df_9517_e4237e5ad19e
type: Species
constant: false
name: GGT7
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is: A0PJJ9
initial amount: NaN
is encoded by: hsa:2686

metaR FTCD
is version of: http://identifiers.org/ec-code/2.1.2.5
reversible: false
product: MODEL1310110023#
fast: false
is: SBO:0000176
reactant: MODEL1310110023#
name: formimidoyltransferase cyclodeaminase
kinetic law: MODEL1310110023#
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Folate metabolism EC Number: 4.3.1.4 Confidence Level: 4 AUTHORS: PMID:14697341 NOTES:IT
modifier: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_4ec01d02_ddf2_4e2f_9660_e102fadea1a4
boundary condition: true
name: NDUFA12
has only substance units: false
is encoded by: hsa:55967
is: SBO:0000252
type: Species
is: F8VQS7
constant: false
initial concentration: NaN
initial amount: NaN

metaR r1630
is described by: ECO:0000000
product: MODEL1310110023#
fast: false
reactant: MODEL1310110023#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110023#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110023#_8fbe8887_68b8_4717_839a_cd299bb04788
constant: false
is encoded by: hsa:4713
initial concentration: NaN
is: P17568
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
name: NDUFB7

http://identifiers.org/biomodels.db/MODEL1310110023#_b2fafe8a_5334_4c72_984d_5d7b36a85b01
name: PLCE1
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:51196
is: Q9P212

http://identifiers.org/biomodels.db/MODEL1310110023#_8cf30ce4_a3b2_4966_9a00_e9837425408d
initial amount: NaN
name: ALDH3B2
constant: false
initial concentration: NaN
is encoded by: hsa:222
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
is: P48448

metaM bilglcur c
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:57767
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: mono(glucosyluronic acid)bilirubin(2-)
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374

metaM prgstrn c
constant: false
boundary condition: false
is: HMDB01830
type: Species
initial amount: NaN
is: SBO:0000247
name: progesterone
notes: FORMULA: C21H30O2 CHARGE: 0 INCHI: InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C00410
has only substance units: false
is: CHEBI:17026
initial concentration: 1.0

metaR TYMSULT
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
reversible: false
product: MODEL1310110023#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (6818.3) or (6818.1) or (6817.4) or (6817.1) or (6817.3) or (6818.2) or (6817.2) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:TV/RS (6/14/05)
is version of: http://identifiers.org/ec-code/2.8.2.1
fast: false
type: Reaction
name: Tyramine Sulfotransferase

http://identifiers.org/biomodels.db/MODEL1310110023#_cd49d554_737e_49ed_9db7_77fd65f017e1
name: _AI972237_1_c
type: Species
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AI972237
initial concentration: NaN
initial amount: NaN

metaM 5dhf e
initial concentration: 1.0
name: pentaglutamyl folate (DHF)
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
is: SBO:0000247
has only substance units: false
constant: false
type: Species
is: HMDB06487
initial amount: NaN
boundary condition: false

metaM HC01496 m
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
boundary condition: false
has only substance units: false
is: CHEBI:28095
name: 2-Amino-3-oxoadipate
type: Species
constant: false

metaM core6 l
initial amount: NaN
is: SBO:0000247
is: CHEBI:12936
constant: false
is: HMDB00143
initial concentration: 1.0
notes: FORMULA: C16H27N2O10X CHARGE: 0
boundary condition: false
has only substance units: false
name: Core 6
type: Species

metaM glc D c
is: CHEBI:4167
boundary condition: false
name: D-glucose
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB00122
constant: false
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: SBO:0000247

metaR r2060
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
reversible: false
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000000
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
is: SBO:0000185

metaR CSEPASEly
fast: false
kinetic law: MODEL1310110023#
reversible: false
is described by: ECO:0000000
name: chondroitin sulfate E proteoglycan protease, lysosome (endosome)
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
is: SBO:0000176
product: MODEL1310110023#
type: Reaction

metaM ksii core2 g
is: HMDB01644
is: SBO:0000247
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
initial amount: NaN
initial concentration: 1.0
name: keratan sulfate II (core 2-linked)
boundary condition: false
constant: false
is: CHEBI:17140
has only substance units: false
type: Species

metaM fdp c
boundary condition: false
is: CHEBI:16905
is: HMDB01058
constant: false
initial amount: NaN
is: C00354
initial concentration: 1.0
is: SBO:0000247
type: Species
name: D-Fructose 1,6-bisphosphate
has only substance units: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00300 EHMN_ABBREVIATION: C00354
is: http://identifiers.org/pubchem.compound/3647

http://identifiers.org/biomodels.db/MODEL1310110023#_f0f14f7f_3b10_493a_8f0e_a6c1d40b80e3
name: HSD3B1
has only substance units: false
is: P14060
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:3283

metaM leuktrA4 c
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
initial concentration: 1.0
type: Species
is: HMDB01337
boundary condition: false
initial amount: NaN
is: CHEBI:57463
has only substance units: false
is: SBO:0000247
name: leukotriene A4(1-)
constant: false

metaR TSTSTERONEtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is described by: ECO:0000000
reactant: MODEL1310110023#
reversible: true
kinetic law: MODEL1310110023#
is: SBO:0000185
name: testosterone intracellular transport
type: Reaction
product: MODEL1310110023#
fast: false

metaR PROSTGH2t
is described by: ECO:0000269
fast: false
product: MODEL1310110023#
is: SBO:0000185
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
name: Prostaglandin H2 transport
reactant: MODEL1310110023#
reversible: true
type: Reaction

metaR RE2659R
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
reactant: MODEL1310110023#
is: SBO:0000176
name: RE2659
reversible: true
kinetic law: MODEL1310110023#
product: MODEL1310110023#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110023#_ee366343_e844_496a_a05d_46b0d1ef15a3
type: Species
has only substance units: false
constant: false
boundary condition: true
is: O14880
initial concentration: NaN
is encoded by: hsa:4259
initial amount: NaN
name: MGST3
is: SBO:0000252

metaR DM ethamp r
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

metaM icit m
is: CHEBI:16087
initial concentration: 1.0
initial amount: NaN
is: C00311
constant: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
is: HMDB00193
is: SBO:0000247
has only substance units: false
type: Species
name: Isocitrate
boundary condition: false

metaM HC02204 c
constant: false
type: Species
is: SBO:0000247
name: prostaglandin-b1
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:27624
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959

metaM cs a deg4 l
is: HMDB01354
initial concentration: 1.0
is: SBO:0000247
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 4
is: CHEBI:57455
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C31H49NO29S CHARGE: -2
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_ec9d5067_1acb_428b_b7a9_506964754445
is: SBO:0000252
name: _728226_1_e
boundary condition: true
initial amount: NaN
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:728226

metaR r1636
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110023#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
reactant: MODEL1310110023#

metaR sink 5hpet LPAREN c RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: sink reaction for 5(S)-HPETE(1-)
type: Reaction

metaR r1559
reactant: MODEL1310110023#
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110023#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110023#

metaM idour e
is: HMDB02704
is: SBO:0000247
type: Species
name: L-iduronate
is: CHEBI:21338
initial concentration: 1.0
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110023#_c45408dc_6c13_4573_873b_57b9e37e1eab
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:6522
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: F8W682
name: SLC4A2

metaR ABUTD
type: Reaction
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
product: MODEL1310110023#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (223.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.19 Confidence Level: 4 AUTHORS: PMID:8786138 NOTES:JLR
reversible: false
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110023#
name: Aminobutyraldehyde dehydrogenase

metaM ethamp r
has only substance units: false
boundary condition: false
name: O-phosphonatoethanaminium(1-)
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
constant: false
is: SBO:0000247
type: Species
is: CHEBI:58190
is: HMDB00224
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_d4351aa9_f87f_4043_84b2_c63b8dfbaa90
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:2878
type: Species
initial concentration: NaN
is: P22352
name: GPX3

http://identifiers.org/biomodels.db/MODEL1310110023#_5f1c7bba_8cd2_4115_9240_47bb1a44a269
has only substance units: false
is: Q3KQV9
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: UAP1L1
type: Species
is encoded by: hsa:91373
constant: false
initial amount: NaN

metaR EX HC02205 LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b2 exchange
type: Reaction

metaR FAOXC226C227m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:7)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_1c5fd942_45fb_4f01_ad15_c0d826dd5903
initial amount: NaN
is: Q16853
constant: false
is: SBO:0000252
name: AOC3
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:8639
has only substance units: false

metaM dmnoncoa x
type: Species
initial concentration: 1.0
name: 4,8 dimethylnonanoyl-CoA
is: HMDB11604
initial amount: NaN
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_89f6a79c_63bd_4fc7_a314_fbf84a4ae600
type: Species
initial concentration: NaN
is: Q9NP56
boundary condition: true
is: SBO:0000252
name: PDE7B
has only substance units: false
is encoded by: hsa:27115
constant: false
initial amount: NaN

metaR r1635
modifier: MODEL1310110023#
reactant: MODEL1310110023#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110023#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110023#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_016b9617_574d_419f_aa4f_8858fafcbe4f
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:47
type: Species
is: SBO:0000252
name: ACLY

metaR GALASE17ly
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
name: beta-galactosidase, lysosomal
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110023#
reversible: false
is described by: ECO:0000000

metaM biliverd c
boundary condition: false
constant: false
initial amount: NaN
name: biliverdin(2-)
notes: FORMULA: C33H32N4O6 CHARGE: -2 INCHI: InChI=1S/C33H34N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-15,35H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14-,28-15- EHMN_ABBREVIATION: C00500
is: SBO:0000247
has only substance units: false
is: HMDB01008
initial concentration: 1.0
is: CHEBI:57991
type: Species

metaR NACHEXA20ly
product: MODEL1310110023#
fast: false
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase A, lysosomal
kinetic law: MODEL1310110023#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110023#
type: Reaction
modifier: MODEL1310110023#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD

metaM HC01434 c
constant: false
name: oxalatosuccinate(3-)
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
initial amount: NaN
is: CHEBI:58931
type: Species
boundary condition: false
initial concentration: 1.0

metaM leuktrA4 e
initial amount: NaN
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
is: HMDB01337
is: CHEBI:57463
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
type: Species
name: leukotriene A4(1-)

metaR DIGALSIDEtl
kinetic law: MODEL1310110023#
is: SBO:0000185
name: digalside hs intracellular transport
is described by: ECO:0000000
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
fast: false
reactant: MODEL1310110023#
reversible: true
type: Reaction

metaM ksii core2 l
initial concentration: 1.0
is: HMDB01644
type: Species
boundary condition: false
is: CHEBI:17140
initial amount: NaN
name: keratan sulfate II (core 2-linked)
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
is: SBO:0000247
constant: false
has only substance units: false

metaM HC02204 e
name: prostaglandin-b1
is: CHEBI:27624
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959

http://identifiers.org/biomodels.db/MODEL1310110023#_5032c959_967c_4fbc_b7a6_a90b11db89e0
name: AFMID
boundary condition: true
type: Species
is encoded by: hsa:125061
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
is: Q63HM1
initial concentration: NaN

metaM pmtcrn x
is: CHEBI:17490
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
type: Species
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB00222
initial amount: NaN
name: L-palmitoylcarnitine
has only substance units: false

metaR AG13T7g
fast: false
is: SBO:0000176
reversible: false
modifier: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.4.1.149
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110023#
is described by: ECO:0000000
kinetic law: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_61609daa_db96_48e6_b77c_79442904108e
constant: false
boundary condition: true
is encoded by: hsa:2974
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
name: GUCY1B2
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110023#_70a6ddca_400c_49be_be1e_7f57899a5e58
is: SBO:0000252
is encoded by: hsa:83530
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
name: _83530_1_c
boundary condition: true
constant: false

metaM HC01115 c
constant: false
name: NeuNGc
initial amount: NaN
is: CHEBI:29025
boundary condition: false
has only substance units: false
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
initial concentration: 1.0
is: SBO:0000247
type: Species

metaR r1634
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reversible: true
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110023#_5703e343_f7a6_4316_810c_2b67f5eba37c
boundary condition: true
has only substance units: false
is encoded by: hsa:6818
name: SULT1A3
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
is: P50224

metaM idour c
constant: false
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
boundary condition: false
initial concentration: 1.0
name: L-iduronate
initial amount: NaN
type: Species
is: HMDB02704
is: SBO:0000247
is: CHEBI:21338
has only substance units: false

metaR r1557
is: SBO:0000185
product: MODEL1310110023#
type: Reaction
reactant: MODEL1310110023#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110023#

metaR GLNASNNaEx
reactant: MODEL1310110023#
fast: false
name: L-glutamine/L-asparagine Na-dependent exchange (Gln-L in)
is described by: ECO:0000269
modifier: MODEL1310110023#
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110023#

metaM biocyt m
is: HMDB03134
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
constant: false
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: C05552
is: http://identifiers.org/pubchem.compound/7886
has only substance units: false
name: Biocytin

http://identifiers.org/biomodels.db/MODEL1310110023#_def0bc55_de18_4f3c_a201_b9f02bc3bd79
has only substance units: false
is: B2RDZ2
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:55312
name: RFK
boundary condition: true
initial amount: NaN
constant: false

metaR PGLYCt
reactant: MODEL1310110023#
is described by: ECO:0000269
type: Reaction
reversible: true
name: phosphatidylglycerol transport
product: MODEL1310110023#
kinetic law: MODEL1310110023#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 3.1.3.18 Confidence Level: 2 AUTHORS: PMID:2164460,PMID:6290284 NOTES:
fast: false

metaM cholcoa x
name: choloyl-CoA(4-)
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB01374
is: CHEBI:57373
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
has only substance units: false
constant: false

metaM cdpea c
initial amount: NaN
constant: false
is: CHEBI:57876
notes: FORMULA: C11H19N4O11P2 CHARGE: -1 INCHI: InChI=1S/C11H20N4O11P2/c12-2-4-23-27(19,20)26-28(21,22)24-5-6-8(16)9(17)10(25-6)15-3-1-7(13)14-11(15)18/h1,3,6,8-10,16-17H,2,4-5,12H2,(H,19,20)(H,21,22)(H2,13,14,18)/p-1/t6-,8-,9-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00433 EHMN_ABBREVIATION: C00570
has only substance units: false
is: HMDB01564
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
name: cdpea[c]

metaR RE1522M
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
modifier: MODEL1310110023#
is described by: ECO:0000000
name: RE1522
fast: false
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true

metaR PROt2r
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000304
reversible: true
product: MODEL1310110023#
type: Reaction
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
name: L-proline reversible transport via proton symport
fast: false
reactant: MODEL1310110023#

metaR 4NPHte
name: xenobiotic transport
fast: false
reactant: MODEL1310110023#
type: Reaction
product: MODEL1310110023#
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8385949,PMID:9219629 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Physiological, Rat
is described by: ECO:0000000
is: SBO:0000185
reversible: true

metaR THBPT4ACAMDASE
is version of: http://identifiers.org/ec-code/4.2.1.96
reversible: false
fast: false
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
is: SBO:0000176
product: MODEL1310110023#
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
modifier: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_df4fc4a6_966f_4308_bc3a_9329c88218de
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: _HG2846_HT2983_1_c
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:HG2846-HT2983
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_270a687b_7e34_43ad_a00e_46037dff7894
is: H0YMZ7
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5151
constant: false
boundary condition: true
type: Species
initial concentration: NaN
name: PDE8A
initial amount: NaN

metaR r1633
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110023#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110023#
is described by: ECO:0000000
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaM udpgal c
constant: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
is: SBO:0000247
is: HMDB00302
boundary condition: false
type: Species
is: CHEBI:58439
name: UDP-D-galactose(2-)
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR ORNLEUrBATtc
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Ornithine into the cell in exchange for L-Leucine by b0,+AT transporter at the apical surfaces of the membranes of small intestine and renal cells.
type: Reaction

metaR FAOXC13C11m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C13-->C11)m
type: Reaction

metaR r1556
product: MODEL1310110023#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
reactant: MODEL1310110023#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM CE2421 m
initial concentration: 1.0
is: HMDB02329
initial amount: NaN
constant: false
boundary condition: false
name: (3S)-3-hydroxylinoleoyl-CoA
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:30623
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421

metaM e4hglu m
boundary condition: false
name: erythro-4-hydroxy-L-glutamate(1-)
is: CHEBI:6331
initial concentration: 1.0
type: Species
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947
initial amount: NaN
is: HMDB02273
is: SBO:0000247
constant: false
has only substance units: false

metaR EX octa LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoate (n-C8:0)
type: Reaction

metaM prostgi2 e
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: prostaglandin I2(1-)
is: CHEBI:57403
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
initial amount: NaN
is: HMDB01335
is: SBO:0000247

metaR CH25H
reversible: false
product: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: (9023.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.14.99.38
name: cholesterol 25-hydroxylase
kinetic law: MODEL1310110023#
fast: false
reactant: MODEL1310110023#
is described by: ECO:0000269
is: SBO:0000176

metaR r0186
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110023#
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
kinetic law: MODEL1310110023#
product: MODEL1310110023#
is: SBO:0000176
type: Reaction
fast: false
modifier: MODEL1310110023#
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.5

metaM pmtcrn r
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17490
name: L-palmitoylcarnitine
is: SBO:0000247
is: HMDB00222
type: Species
boundary condition: false
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990

metaR HS1ly
is described by: ECO:0000000
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.10.1.1
type: Reaction
fast: false
name: heparan-N-sulfatase, lysosomal
product: MODEL1310110023#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
reactant: MODEL1310110023#

metaM gdpfuc c
is: SBO:0000247
boundary condition: false
is: HMDB01095
constant: false
type: Species
is: CHEBI:57984
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
has only substance units: false
name: GDP-L-fucose(2-)
initial amount: NaN
initial concentration: 1.0

metaM melatn c
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16796
constant: false
is: HMDB01389
is: SBO:0000247
name: melatonin
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C13H16N2O2 CHARGE: 0 INCHI: InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16) EHMN_ABBREVIATION: C01598

metaR r1401
type: Reaction
fast: false
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.3.1.51
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.2.1.35
kinetic law: MODEL1310110023#
name: Facilitated diffusion
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.3.1.41
is version of: http://identifiers.org/ec-code/2.7.10.1
notes: GENE_ASSOCIATION: (AA177072.1) or (AA203143.1) or (56894.1) or (56895.1) or (AGPAT7.1) or (AI818585.1) or (AI971023.1) or (1956.1) or (54898.1) or (60481.1) or (79071.1) or (114799.1) or (157570.1) or (8372.1) or (LOC647190.1) or (9926.1) or (129642.1) or (MBOAT5.1) or (79143.1) or (N63787.1) or (54995.1) or (80339.1) or (9197.1) or (6901.1) or (W87865.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6361812,PMID:8132483 NOTES:
reversible: false
reactant: MODEL1310110023#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.1.3

metaM glutcoa m
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
type: Species
boundary condition: false
is: HMDB01339
name: glutaryl-CoA(5-)
is: CHEBI:57378
initial amount: NaN

metaR r1639
is: SBO:0000185
reversible: true
modifier: MODEL1310110023#
reactant: MODEL1310110023#
fast: false
product: MODEL1310110023#
kinetic law: MODEL1310110023#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaM glyc S c
initial amount: NaN
is: CHEBI:33871
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C3H5O4 CHARGE: 0
type: Species
is: HMDB06372
name: (S)-Glycerate

http://identifiers.org/biomodels.db/MODEL1310110023#_dfcfe6d8_7378_48d6_8836_5a641efdb7f5
initial amount: NaN
constant: false
type: Species
boundary condition: true
name: CHST5
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:23563
has only substance units: false

metaR GALt4
reversible: true
fast: false
name: galactose transport via sodium symport
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
reactant: MODEL1310110023#
product: MODEL1310110023#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110023#_e1c7c95b_efc1_4272_86ff_4ea928e7d8dc
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
name: UROD
is encoded by: hsa:7389
is: P06132
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_f5f165d1_761b_44e9_9245_f5a3216af2be
is: SBO:0000252
boundary condition: true
is: Q15849
has only substance units: false
initial amount: NaN
name: SLC14A2
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:8170

metaM 2dp6mobq m
name: 2-decaprenyl-6-methoxy-1,4-benzoquinone
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C57H86O3 CHARGE: 0 INCHI: InChI=1S/C57H86O3/c1-44(2)22-13-23-45(3)24-14-25-46(4)26-15-27-47(5)28-16-29-48(6)30-17-31-49(7)32-18-33-50(8)34-19-35-51(9)36-20-37-52(10)38-21-39-53(11)40-41-54-42-55(58)43-56(60-12)57(54)59/h22,24,26,28,30,32,34,36,38,40,42-43H,13-21,23,25,27,29,31,33,35,37,39,41H2,1-12H3/b45-24+,46-26+,47-28+,48-30+,49-32+,50-34+,51-36+,52-38+,53-40+
boundary condition: false
is: CHEBI:50773
initial concentration: 1.0

metaR RE0944E
is version of: http://identifiers.org/ec-code/3.2.1.17
name: RE0944
type: Reaction
reactant: MODEL1310110023#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.1
product: MODEL1310110023#
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
reversible: true

metaR CSPG Atly
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
reactant: MODEL1310110023#
product: MODEL1310110023#
type: Reaction
kinetic law: MODEL1310110023#
name: chondroitin sulfate A transport, extracellular to lysosome
is: SBO:0000185
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110023#_37736dfb_dd7a_4dbf_8001_8320e52018f5
is encoded by: hsa:6716
boundary condition: true
initial concentration: NaN
constant: false
name: SRD5A2
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
is: P31213

metaR RE2626C
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110023#
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
kinetic law: MODEL1310110023#
is: SBO:0000176
type: Reaction
fast: false
name: RE2626

metaR r1638
reactant: MODEL1310110023#
product: MODEL1310110023#
type: Reaction
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
fast: false

metaR MANt1r
fast: false
is described by: ECO:0000269
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
reversible: true
modifier: MODEL1310110023#
type: Reaction
is: SBO:0000185
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (6513.1) or (6515.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:NCD
name: mannose transport (uniport)

http://identifiers.org/biomodels.db/MODEL1310110023#_d3592447_3b3e_4163_8802_5c93e5d644bc
is encoded by: hsa:56606
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
name: SLC2A9
is: Q9NRM0

http://identifiers.org/biomodels.db/MODEL1310110023#_0461cf54_d0f8_40c3_ada0_9028a610b965
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: Q13613
name: MTMR1
initial concentration: NaN
is encoded by: hsa:8776
type: Species
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_b3586ace_5f8f_4af9_9b48_29cf88684a44
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:23761
is: SBO:0000252
name: PISD
boundary condition: true
is: Q9UG56
constant: false
initial amount: NaN

metaR O2St
reactant: MODEL1310110023#
is: SBO:0000185
reversible: true
product: MODEL1310110023#
kinetic law: MODEL1310110023#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
name: superoxide anion transport via diffusion (extracellular)
is described by: ECO:0000000

metaM prostgi2 c
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:57403
constant: false
is: HMDB01335
name: prostaglandin I2(1-)

metaM 3hexdtetcoa m
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
has only substance units: false
initial concentration: 1.0
is: HMDB02288
name: 3,7,10,13-hexadecatetraenoylcoa
boundary condition: false
is: SBO:0000247

metaM btn m
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
is: CHEBI:57586
has only substance units: false
name: biotinate
is: HMDB00030
constant: false
is: SBO:0000247
initial amount: NaN

metaR r1400
name: Active transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
type: Reaction
reactant: MODEL1310110023#
reversible: false
product: MODEL1310110023#
kinetic law: MODEL1310110023#
is: SBO:0000185
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_34bb3ce0_6433_4a41_a53f_50981262181e
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4705
type: Species
initial amount: NaN
name: NDUFA10
boundary condition: true
constant: false
is: O95299

metaR r1637
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110023#
fast: false
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110023#

metaM pppg9 m
boundary condition: false
initial concentration: 1.0
is: HMDB01097
is: SBO:0000247
initial amount: NaN
is: CHEBI:57307
type: Species
constant: false
has only substance units: false
notes: FORMULA: C34H38N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00656 EHMN_ABBREVIATION: C01079
name: Protoporphyrinogen IX
is: C01079

metaM CE2424 m
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424
boundary condition: false
has only substance units: false
is: CHEBI:28387
initial amount: NaN
constant: false
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA
type: Species
is: HMDB11123

metaM glyc S e
is: CHEBI:33871
is: SBO:0000247
constant: false
name: (S)-Glycerate
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
is: HMDB06372
notes: FORMULA: C3H5O4 CHARGE: 0
initial amount: NaN

metaM hs deg7 l
is: SBO:0000247
name: heparan sulfate, degradation product 7
constant: false
type: Species
notes: FORMULA: C67H99N4O80S8 CHARGE: -9
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB01352
is: CHEBI:17180

metaM lthstrl r
name: 5alpha-cholest-7-en-3beta-ol
type: Species
has only substance units: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189
is: CHEBI:17168
constant: false
is: SBO:0000247
is: HMDB01170
initial concentration: 1.0
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110023#_8534091a_6dc3_4325_ace4_e79ac63d5d9e
is: SBO:0000252
is encoded by: hsa:AF080579
name: _AF080579_1_c
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false

metaM arachd e
has only substance units: false
initial concentration: 1.0
is: HMDB01043
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
name: arachidonate
is: SBO:0000247
constant: false
type: Species
is: CHEBI:32395
initial amount: NaN
boundary condition: false

metaM glc D e
constant: false
initial amount: NaN
name: D-glucose
is: CHEBI:4167
is: SBO:0000247
is: HMDB00122
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110023#_71ac62dc_d648_4b6d_b499_8a7aeffca130
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:1807
type: Species
initial amount: NaN
is: SBO:0000252
name: DPYS
initial concentration: NaN
is: Q14117

metaM pmtcrn m
initial amount: NaN
is: SBO:0000247
is: CHEBI:17490
initial concentration: 1.0
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
type: Species
is: HMDB00222
name: L-palmitoylcarnitine
boundary condition: false
has only substance units: false
constant: false

metaM gdpfuc g
constant: false
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
is: SBO:0000247
is: HMDB01095
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
name: GDP-L-fucose(2-)
boundary condition: false
is: CHEBI:57984

metaR ACNAMlt
kinetic law: MODEL1310110023#
is described by: ECO:0000269
fast: false
is: SBO:0000185
type: Reaction
name: N-acetylneuraminate transport into lysososme
modifier: MODEL1310110023#
reversible: true
reactant: MODEL1310110023#
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ

http://identifiers.org/biomodels.db/MODEL1310110023#_e2a3ee8a_4b81_47a1_ad34_b697d836f1e3
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: Q16762
has only substance units: false
initial amount: NaN
is encoded by: hsa:7263
constant: false
name: TST
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_194a7957_9b16_439c_941b_4b80f34a5062
is encoded by: hsa:54
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is: P13686
type: Species
is: SBO:0000252
name: ACP5

http://identifiers.org/biomodels.db/MODEL1310110023#_70aeec46_2d49_4269_8a82_627cd716bd69
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
name: ZADH2
is: SBO:0000252
initial amount: NaN
is: Q8N4Q0
type: Species
is encoded by: hsa:284273

metaM peamn c
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:225237
constant: false
name: 2-phenylethanaminium
is: HMDB12275
notes: FORMULA: C8H12N CHARGE: 1 INCHI: InChI=1S/C8H11N/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7,9H2/p+1 EHMN_ABBREVIATION: C05332
boundary condition: false
initial concentration: 1.0

metaM bilirub e
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
name: bilirubin(2-)
is: CHEBI:57977
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
constant: false
is: HMDB00054
boundary condition: false

metaM pa hs c
constant: false
is: CHEBI:57739
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
has only substance units: false
initial concentration: 1.0
name: phosphatidate(2-)
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110023#_6507ac30_b621_4b4f_ac93_cc470e05a751
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
is: Q8TE04
name: PANK1
boundary condition: true
is encoded by: hsa:53354
type: Species
has only substance units: false

metaR IDOURte
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
reversible: true
type: Reaction
fast: false
is: SBO:0000185
name: L-iduronate transport, extracellular
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
product: MODEL1310110023#

metaR G14T15g
type: Reaction
fast: false
modifier: MODEL1310110023#
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.4.1.90
reactant: MODEL1310110023#
reversible: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176

metaM glac c
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:18268
is: HMDB06355
name: D-glucurono-6,3-lactone
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
constant: false
has only substance units: false
type: Species

metaM cbasp e
is: C00438
initial concentration: 1.0
notes: FORMULA: C5H6N2O5 CHARGE: -2
initial amount: NaN
is: HMDB00828
has only substance units: false
name: N-Carbamoyl-L-aspartate
is: SBO:0000247
type: Species
constant: false
is: CHEBI:32814
boundary condition: false

metaM acglcgalgluside hs g
constant: false
name: N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide
has only substance units: false
initial amount: NaN
is: CHEBI:17103
notes: FORMULA: C38H69N2O17FULLRCO CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false

metaM idour l
is: CHEBI:21338
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
name: L-iduronate
is: HMDB02704

metaM but c
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
is: HMDB00039
name: butyrate
is: SBO:0000247
is: CHEBI:17968
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_8cdb819b_e8d6_4ec1_8867_3463a517c2fe
constant: false
is: Q9UHI7
initial concentration: NaN
type: Species
name: SLC23A1
is: SBO:0000252
boundary condition: true
is encoded by: hsa:9963
initial amount: NaN
has only substance units: false

metaM prostgd2 c
name: prostaglandin D2(1-)
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
boundary condition: false
is: HMDB01403
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:57406
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_2260a765_b54a_4567_8b6c_37ec1da41422
boundary condition: true
is: P00374
name: DHFR
constant: false
is encoded by: hsa:1719
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species

metaR GBA
notes: GENE_ASSOCIATION: (2629.2) or (2629.3) or (2629.4) or (2629.5) or (2629.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 0 AUTHORS: PMID:15982918 NOTES:NJ
reversible: false
name: Glucosylceramidase
reactant: MODEL1310110023#
product: MODEL1310110023#
kinetic law: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.45
fast: false
modifier: MODEL1310110023#
type: Reaction

metaR RE3273C
name: RE3273
is: SBO:0000176
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:3135804 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/3.1.4.4
product: MODEL1310110023#
reactant: MODEL1310110023#
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
is described by: ECO:0000000
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_62153789_3439_4ec0_b405_a9263fca6675
has part: B4E3E9
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
name: DLD:DLST:OGDH:PDHX
type: Species
is encoded by: hsa:4967
is: SBO:0000297
initial amount: NaN

metaM trp L e
constant: false
initial amount: NaN
is: CHEBI:16828
has only substance units: false
type: Species
is: HMDB00929
is: SBO:0000247
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
name: L-tryptophan
boundary condition: false
initial concentration: 1.0

metaM arachd c
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
name: arachidonate
is: HMDB01043
is: SBO:0000247
constant: false
type: Species
is: CHEBI:32395
boundary condition: false
has only substance units: false

metaM pchol hs c
type: Species
constant: false
name: Phosphatidylcholine
is: CHEBI:16110
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false
initial concentration: 1.0

metaM ksi deg26 l
boundary condition: false
initial amount: NaN
is: HMDB00061
is: CHEBI:58343
type: Species
is: SBO:0000247
name: keratan sulfate I, degradation product 26
constant: false
notes: FORMULA: C110H179N7O93S4 CHARGE: -4
initial concentration: 1.0
has only substance units: false

metaR CITRtm
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is: SBO:0000185
reactant: MODEL1310110023#
type: Reaction
modifier: MODEL1310110023#
is described by: ECO:0000269
product: MODEL1310110023#
fast: false
reversible: true
name: citrulline mitochondrial transport via proton antiport

metaM coucoa m
is: CHEBI:57355
constant: false
notes: FORMULA: C30H38N7O18P3S1 CHARGE: -4 INCHI: InChI=1S/C30H42N7O18P3S/c1-30(2,25(42)28(43)33-10-9-20(39)32-11-12-59-21(40)8-5-17-3-6-18(38)7-4-17)14-52-58(49,50)55-57(47,48)51-13-19-24(54-56(44,45)46)23(41)29(53-19)37-16-36-22-26(31)34-15-35-27(22)37/h3-8,15-16,19,23-25,29,38,41-42H,9-14H2,1-2H3,(H,32,39)(H,33,43)(H,47,48)(H,49,50)(H2,31,34,35)(H2,44,45,46)/p-4/t19-,23-,24-,25+,29-/m1/s1
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: 4-coumaroyl-CoA(4-)
has only substance units: false
is: C00223
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_eb2a7145_4266_4118_b858_7cdf474b03e0
boundary condition: true
is encoded by: hsa:5471
has only substance units: false
name: PPAT
is: Q06203
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_d55f44de_b4d6_486e_bdea_5effcb9a90b0
constant: false
type: Species
initial amount: NaN
is: Q9UJM8
name: HAO1
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:54363

http://identifiers.org/biomodels.db/MODEL1310110023#_827fbe33_4a9c_48c9_ad4d_391f92f57871
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:10587
name: TXNRD2
type: Species

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_a33027aa_e834_47f2_b261_2f9abd601488
is encoded by: hsa:276
type: Species
initial concentration: NaN
name: AMY1A
has only substance units: false
is: Q6NSB3
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110023#_eadd8a2d_7d84_4f95_b3d6_80e65a97a3bb
name: ADH1A:ADH1B
is: SBO:0000297
has part: P07327
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:124
constant: false

metaM cbasp c
is: C00438
has only substance units: false
initial amount: NaN
is: HMDB00828
name: N-Carbamoyl-L-aspartate
type: Species
notes: FORMULA: C5H6N2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00356 EHMN_ABBREVIATION: C00438
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:32814
initial concentration: 1.0

metaM triodthy c
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
name: 3,3',5-triiodo-L-thyronine
has only substance units: false
constant: false
is: CHEBI:18258
initial amount: NaN
is: HMDB00265
boundary condition: false

metaM but e
is: SBO:0000247
is: CHEBI:17968
name: butyrate
initial concentration: 1.0
is: HMDB00039
constant: false
boundary condition: false
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_5b403e73_9484_44f1_91cc_df8a49737025
constant: false
initial concentration: NaN
is encoded by: hsa:257068
has only substance units: false
boundary condition: true
is: Q0VAA5
is: SBO:0000252
initial amount: NaN
name: PLCXD2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_3ae1a2b1_176d_46a9_af43_1e0cf317931a
has only substance units: false
boundary condition: true
name: ME3
is: Q6TCH8
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:10873
type: Species
constant: false
initial amount: NaN

metaM glc D g
initial amount: NaN
is: CHEBI:4167
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
name: D-glucose
initial concentration: 1.0
is: HMDB00122
type: Species
constant: false
has only substance units: false

metaM 4h2oglt m
initial amount: NaN
is: HMDB02070
notes: FORMULA: C5H4O6 CHARGE: -2 INCHI: InChI=1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)/p-2
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: 4-hydroxy-2-oxoglutarate(2-)
type: Species
is: CHEBI:17742
is: SBO:0000247
constant: false

metaM biocyt e
is: C05552
has only substance units: false
name: Biocytin
constant: false
is: http://identifiers.org/pubchem.compound/7886
type: Species
initial amount: NaN
is: HMDB03134
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaM prostgd2 e
type: Species
name: prostaglandin D2(1-)
is: HMDB01403
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:57406

metaR NACHEX25ly
reversible: false
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110023#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_d8446fb7_ec16_4ba6_9b32_964a8ad6086a
is: P78542
constant: false
type: Species
name: HK1
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3098
initial amount: NaN
boundary condition: true

metaR SERTHRNaEx
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110023#
is: SBO:0000185
reactant: MODEL1310110023#
product: MODEL1310110023#
reversible: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110023#
name: L-serine/L-threonine Na-dependent exchange (Ser-L in)
fast: false

metaM bilglcur r
initial concentration: 1.0
is: SBO:0000247
name: mono(glucosyluronic acid)bilirubin(2-)
is: CHEBI:57767
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
boundary condition: false
constant: false

metaR r1843
name: Y+LAT2 Utilized transport
reactant: MODEL1310110023#
is described by: ECO:0000000
product: MODEL1310110023#
fast: false
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185

metaM btcoa c
initial amount: NaN
is: SBO:0000247
name: Butanoyl-CoA
is: HMDB01088
type: Species
initial concentration: 1.0
is: C00136
boundary condition: false
has only substance units: false
is: CHEBI:57371
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_d1f2577c_9902_485a_abac_0333a80cdf10
is encoded by: hsa:85365
name: ALG2
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
constant: false

metaR C226COAtx
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
product: MODEL1310110023#
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110023#
is described by: ECO:0000000
name: fatty acid intracellular transport
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110023#_8c5b1241_a3bf_4029_87d5_b4fd6e876d7e
name: HYALP1
is encoded by: hsa:26062
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN

metaM bilirub c
boundary condition: false
type: Species
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
constant: false
is: SBO:0000247
name: bilirubin(2-)
is: HMDB00054
initial amount: NaN
is: CHEBI:57977
has only substance units: false
initial concentration: 1.0

metaR MG1er
is version of: http://identifiers.org/ec-code/3.2.1.106
notes: GENE_ASSOCIATION: (7841.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.106 Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110023#
is: SBO:0000176
type: Reaction
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
product: MODEL1310110023#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110023#
reversible: false
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_e61e3785_dd78_4f3a_8103_b64c7bcc0167
constant: false
is: SBO:0000252
is encoded by: hsa:AA278423
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: _AA278423_1_m
has only substance units: false

metaR ABTD
reversible: true
name: L-arabinitol 4-dehydrogenase
type: Reaction
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
reactant: MODEL1310110023#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110023#
is: SBO:0000176

metaR FAOXC163C164x
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_4b9f69c4_f018_46a7_839c_1bc48b326295
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2530
name: FUT8
is: A8K8P8
type: Species

metaM leuktrA4 r
is: SBO:0000247
is: HMDB01337
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
name: leukotriene A4(1-)
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
is: CHEBI:57463

metaM btn e
initial amount: NaN
notes: FORMULA: C10H15N2O3S CHARGE: -1
name: Biotin
initial concentration: 1.0
is: CHEBI:3420
type: Species
is: C00120
is: SBO:0000247
boundary condition: false
is: HMDB00030
has only substance units: false
constant: false

metaR EX HC02207 LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-c2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_9113e938_2457_4900_9539_1bddf774023f
type: Species
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q15758
name: SLC1A5
is encoded by: hsa:6510

metaM amet r
is: HMDB01185
notes: FORMULA: C15H23N6O5S CHARGE: 1 INCHI: InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/p+1/t7-,8+,10+,11+,14+,27?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
constant: false
name: S-adenosyl-L-methionine
type: Species
initial amount: NaN
is: CHEBI:15414
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110023#_63fa52eb_926a_4aee_9e2b_3bcce901c400
is encoded by: hsa:10087
constant: false
type: Species
boundary condition: true
is: Q9Y5P4
is: SBO:0000252
name: COL4A3BP
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR RE2649C
modifier: MODEL1310110023#
name: RE2649
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.65
is version of: http://identifiers.org/ec-code/3.1.2.2
kinetic law: MODEL1310110023#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
product: MODEL1310110023#
is: SBO:0000176
reactant: MODEL1310110023#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_9669516f_e8a3_4870_998f_71f0bf9929b6
initial amount: NaN
constant: false
is encoded by: hsa:100128062
has only substance units: false
is: SBO:0000252
name: _100128062_1_m
initial concentration: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_7b942c65_dee8_4077_bbf9_1fbe719d0e34
name: BAAT
constant: false
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:570
is: Q14032
boundary condition: true
initial amount: NaN

metaM HC01434 x
is: SBO:0000247
is: CHEBI:58931
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
name: oxalatosuccinate(3-)
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false

metaR GHMT2r
modifier: MODEL1310110023#
name: glycine hydroxymethyltransferase, reversible
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.1.2.1
is: SBO:0000176
reversible: true
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (6470.1) or (6470.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
product: MODEL1310110023#
type: Reaction

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_8997fcd6_be82_4dd7_9f56_90cfb91aedaa
boundary condition: true
name: SLC24A1
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:9187
is: B4DUG1

metaR RE2079R
reversible: true
kinetic law: MODEL1310110023#
is: SBO:0000176
fast: false
reactant: MODEL1310110023#
product: MODEL1310110023#
name: RE2079
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
is described by: ECO:0000000

metaR MI145PK
kinetic law: MODEL1310110023#
type: Reaction
name: inositol-1,4,5-trisphosphate 3-kinase
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.1.127
is: SBO:0000176
modifier: MODEL1310110023#
reactant: MODEL1310110023#
fast: false
product: MODEL1310110023#

metaM ps hs e
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:18303
name: phosphatidylserine
is: SBO:0000247
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006

metaR NDPK6m
is described by: ECO:0000254
modifier: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
reversible: true
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6

http://identifiers.org/biomodels.db/MODEL1310110023#_f161d498_36d2_426c_8a95_a66abec80df2
is: SBO:0000252
constant: false
is encoded by: hsa:51292
name: GMPR2
initial amount: NaN
is: Q9P2T1
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN

metaR FCLTm
name: Ferrochelatase, mitochondrial
reactant: MODEL1310110023#
is: SBO:0000176
type: Reaction
is described by: ECO:0000304
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (2235.1) or (2235.2) SUBSYSTEM: Heme synthesis EC Number: 4.99.1.1 Confidence Level: 2 AUTHORS: PMID:7983009 NOTES:NCD; r0096
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/4.99.1.1
reversible: false
fast: false

metaR RE3006M
is: SBO:0000176
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
name: RE3006
reactant: MODEL1310110023#
reversible: true
kinetic law: MODEL1310110023#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
modifier: MODEL1310110023#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_1d8bc3f5_74e8_469b_a821_dc7947ed3a65
is encoded by: hsa:212
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
name: ALAS2
boundary condition: true
is: Q5JZF5
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_ef6fd267_f3bb_4b82_aef8_11faab51e567
is: O00154
constant: false
initial amount: NaN
name: ACOT7
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:11332
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_da0163ae_778e_4b2e_97c0_03c5536d3a76
type: Species
initial concentration: NaN
name: SLC5A1
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
is: P13866
is: SBO:0000252
is encoded by: hsa:6523

http://identifiers.org/biomodels.db/MODEL1310110023#_1cb1b842_c0e8_415a_a3b7_cc66206ba177
type: Species
is: Q9Y345
is encoded by: hsa:9152
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: SLC6A5

http://identifiers.org/biomodels.db/MODEL1310110023#_c75ef0be_bb61_405b_ad2e_d79a2860a0b2
initial concentration: NaN
is: SBO:0000252
type: Species
name: PANK2
constant: false
boundary condition: true
is encoded by: hsa:80025
has only substance units: false
is: Q6P1K9
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_3bf16e2a_aaa4_4de7_8805_1add1d64e772
initial amount: NaN
initial concentration: NaN
type: Species
is: E9PAK4
name: SLC5A9
constant: false
is encoded by: hsa:200010
has only substance units: false
boundary condition: true
is: SBO:0000252

metaM cs e deg3 l
type: Species
is: HMDB00127
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C37H53NO44S4 CHARGE: -6
is: CHEBI:15748
constant: false
boundary condition: false
initial amount: NaN
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 3

metaR TCYNTt
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
is: SBO:0000185
is described by: ECO:0000000
reversible: false
name: Thiocyanate transport via diffusion (cytosol to extracellular)
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
product: MODEL1310110023#

metaR NDPK6n
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000304
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear
is: SBO:0000176
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
modifier: MODEL1310110023#
type: Reaction
kinetic law: MODEL1310110023#

metaR RPE
product: MODEL1310110023#
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
reversible: true
reactant: MODEL1310110023#
name: ribulose 5-phosphate 3-epimerase
kinetic law: MODEL1310110023#
fast: false
is version of: http://identifiers.org/ec-code/5.1.3.1

metaM ksi pre26 g
is: CHEBI:28067
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C199H318N14O166S8X CHARGE: -9
name: keratan sulfate I biosynthesis, precursor 26

metaR r0181
fast: false
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.2.1.5
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110023#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reversible: true
is: SBO:0000176
modifier: MODEL1310110023#
product: MODEL1310110023#
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_42734ca0_9753_44c2_aeac_36f5af177900
constant: false
initial amount: NaN
type: Species
name: PLCG2
initial concentration: NaN
is: P16885
has only substance units: false
is encoded by: hsa:5336
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110023#_ac0c9c8b_afcb_4075_a0d0_8f6187cb5058
type: Species
initial concentration: NaN
is: P12074
is encoded by: hsa:1337
initial amount: NaN
has only substance units: false
constant: false
name: COX6A1
is: SBO:0000252
boundary condition: true

metaM ppa c
initial concentration: 1.0
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
is: SBO:0000247
boundary condition: false
constant: false
type: Species
is: CHEBI:17272
has only substance units: false
name: propionate
is: HMDB00237
initial amount: NaN

metaR PI34P5K
modifier: MODEL1310110023#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
reactant: MODEL1310110023#
fast: false
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.68
kinetic law: MODEL1310110023#
product: MODEL1310110023#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_88e31444_ec78_4e76_b583_cdc41f46dd93
boundary condition: true
is: Q9BT22
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: ALG1
constant: false
is encoded by: hsa:56052
is: SBO:0000252
type: Species

metaR FAOXC226C225x
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)x
type: Reaction

metaR 3HBCOAHLm
is described by: ECO:0000000
reversible: false
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
product: MODEL1310110023#
is: SBO:0000176
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_02376b83_4a08_4cb7_bba0_038d1381a624
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:51227
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
name: PIGP

metaR FAOXC141C121m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:1-->C12:1)m
type: Reaction

metaM 3octdectecoa x
name: 3,6,9,12-octadecatetraenoylcoa
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB02288
constant: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
initial amount: NaN

metaR HESTRATRIOLtr
kinetic law: MODEL1310110023#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism, hydroxylated (inactivated) estrogen derivative needs to be transported out of the cell NJ
type: Reaction
product: MODEL1310110023#
name: hydroxylated estrogen derivative transport
fast: false
reversible: true

metaM amet m
initial amount: NaN
initial concentration: 1.0
is: C00019
has only substance units: false
is: HMDB01185
constant: false
type: Species
is: SBO:0000247
boundary condition: false
name: S-Adenosyl-L-methionine
is: CHEBI:15414
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019

metaR ALAt2r
fast: false
name: L-alanine reversible transport via proton symport
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
is: SBO:0000185
modifier: MODEL1310110023#
reversible: true
is described by: ECO:0000304
kinetic law: MODEL1310110023#
product: MODEL1310110023#
type: Reaction
reactant: MODEL1310110023#

metaM arachd l
is: CHEBI:32395
boundary condition: false
constant: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
type: Species
name: arachidonate
initial amount: NaN
initial concentration: 1.0
is: HMDB01043
is: SBO:0000247
has only substance units: false

metaR APOC LYS BTNP
name: proteolysis of apoC-Lys-btn
product: MODEL1310110023#
kinetic law: MODEL1310110023#
reversible: false
reactant: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000176
type: Reaction
is described by: ECO:0000000

metaR GLACter
kinetic law: MODEL1310110023#
name: D-glucurono-6,3-lactone transport, endoplasmic reticulum
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:3779687 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110023#
product: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_3b6e42ba_6f43_4f75_bbd9_829ae0b938da
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: G6PC
type: Species
is: P35575
constant: false
is encoded by: hsa:2538

metaM gullac r
is: HMDB03466
boundary condition: false
notes: FORMULA: C6H10O6 CHARGE: 0 INCHI: InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3+,4-,5+/m0/s1
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:17587
name: L-gulono-1,4-lactone
constant: false
initial amount: NaN

metaR ESTRADIOLtr
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is described by: ECO:0000000
name: estradiol intracellular transport
is: SBO:0000185
reactant: MODEL1310110023#
product: MODEL1310110023#
kinetic law: MODEL1310110023#

metaM dctp c
is: HMDB00998
name: dCTP
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: CHEBI:16311
constant: false
has only substance units: false
initial amount: NaN
is: C00458

metaM xolest2 hs e
constant: false
boundary condition: false
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
type: Species
name: cholesterol ester
initial amount: NaN
is: SBO:0000247
is: CHEBI:17002
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110023#_a4a6e93b_e833_4a58_b801_c7074cdb4807
is encoded by: hsa:2720
is: SBO:0000252
type: Species
name: GLB1
constant: false
initial concentration: NaN
boundary condition: true
is: P16278
initial amount: NaN
has only substance units: false

metaM ppa e
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB00237
initial amount: NaN
constant: false
is: CHEBI:17272
name: propionate
boundary condition: false
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
type: Species

metaR r1994
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110023#
reversible: false
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaR ARABR
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.21
is version of: http://identifiers.org/ec-code/1.1.1.2
modifier: MODEL1310110023#
name: arabinose reductase
kinetic law: MODEL1310110023#
reversible: false
is: SBO:0000176
product: MODEL1310110023#
fast: false
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:12359133,PMID:15234337,PMID:9823300 NOTES:

metaR MALtm
name: malate transport, mitochondrial
is described by: ECO:0000269
modifier: MODEL1310110023#
reversible: true
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:IF
is: SBO:0000185
product: MODEL1310110023#
type: Reaction
fast: false

metaR EICOSTETt
product: MODEL1310110023#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
type: Reaction
name: fatty acid transport via diffusion
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#

metaR GTHRDtr
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - NJ
is: SBO:0000185
product: MODEL1310110023#
reactant: MODEL1310110023#
reversible: true
name: glutathione transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110023#_0029ed08_0a73_4cfd_8ec1_97eb9a43f522
name: ESCO2
is encoded by: hsa:157570
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
is: Q56NI9
initial concentration: NaN

metaR NaKt
fast: false
notes: GENE_ASSOCIATION: (481.1 and 478.1) or (477.1 and 23439.1) or (483.1 and 476.1) or (481.1 and 480.1) or (482.1 and 478.1) or (482.1 and 476.1) or (482.1 and 477.1) or (481.1 and 476.1) or (23439.1 and 476.1) or (480.1 and 23439.1) or (481.1 and 477.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.9 Confidence Level: 4 AUTHORS: PMID:10456317,PMID:8833915,PMID:9159180 NOTES:AMF TDV (8/25/2005, stoichiometry changed)
is: SBO:0000185
reactant: MODEL1310110023#
name: Na+/K+ exchanging ATPase
is version of: http://identifiers.org/ec-code/3.6.3.9
reversible: false
modifier: MODEL1310110023#
type: Reaction
kinetic law: MODEL1310110023#
is described by: ECO:0000269
product: MODEL1310110023#

metaR SUCOAS1m
type: Reaction
name: Succinate--CoA ligase (GDP-forming)
fast: false
kinetic law: MODEL1310110023#
reversible: true
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
is version of: http://identifiers.org/ec-code/6.2.1.4
is: SBO:0000176
product: MODEL1310110023#
modifier: MODEL1310110023#
is described by: ECO:0000000
reactant: MODEL1310110023#

metaR EX gdp LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GDP exchange
type: Reaction

metaM urcan c
is: C00785
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB00301
initial concentration: 1.0
is: SBO:0000247
name: Urocanate
is: CHEBI:17771
notes: FORMULA: C6H5N2O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00534 EHMN_ABBREVIATION: C00785
type: Species

metaM 3sala m
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
name: 3-sulfino-L-alanine (1-)
has only substance units: false
is: CHEBI:61085
type: Species
notes: FORMULA: C3H5NO4S CHARGE: -2 INCHI: InChI=1S/C3H7NO4S/c4-2(3(5)6)1-9(7)8/h2H,1,4H2,(H,5,6)(H,7,8)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
is: C00606
initial amount: NaN

metaM mescon m
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
constant: false
name: Mesaconate
has only substance units: false
type: Species
is: CHEBI:36986
is: HMDB00749
boundary condition: false

metaR FAOXC204C184m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:4-->C18:4)m
type: Reaction

metaM CE4876 r
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876
name: delta12-Prostaglandin J2
has only substance units: false
is: CHEBI:57923
constant: false
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0

metaM retn e
has only substance units: false
boundary condition: false
constant: false
is: HMDB01852
type: Species
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
initial amount: NaN
initial concentration: 1.0
name: all-trans-retinoate
is: CHEBI:35291
is: SBO:0000247

metaM m5mpdol U r
boundary condition: false
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C1545H2540N20O470P20 CHARGE: -20
constant: false
initial amount: NaN
type: Species
is: CHEBI:37634

http://identifiers.org/biomodels.db/MODEL1310110023#_0e1a17b4_695c_4cc9_b775_010694377a07
is: Q96BD0
is: SBO:0000252
type: Species
is encoded by: hsa:28231
boundary condition: true
name: SLCO4A1
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_6ad06a67_d0af_4a64_a008_ebee6f726280
constant: false
initial concentration: NaN
is: F5H123
name: DYLX2
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:9856

http://identifiers.org/biomodels.db/MODEL1310110023#_16cd87c3_b75a_43f1_909b_f4b1f51e2517
name: ST3GAL3
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is: Q11203
is encoded by: hsa:6487
is: SBO:0000252
initial concentration: NaN

metaM hs deg22 l
is: HMDB02704
initial concentration: 1.0
notes: FORMULA: C37H56NO35S CHARGE: -3
is: SBO:0000247
initial amount: NaN
name: IdoA-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
constant: false
type: Species
boundary condition: false
is: CHEBI:21338
has only substance units: false

metaM galgluside hs g
is: HMDB00295
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:58223
name: galactosyl glucosyl ceramide
constant: false
boundary condition: false
is: C00015

metaR ASNGLNNaEx
fast: false
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110023#
reversible: false
type: Reaction
product: MODEL1310110023#
is described by: ECO:0000269
reactant: MODEL1310110023#
is: SBO:0000185
name: L-glutamine/L-asparagine Na-dependent exchange (Asn-L in)

metaR DCSPTN1CRNt
is described by: ECO:0000269
modifier: MODEL1310110023#
reactant: MODEL1310110023#
type: Reaction
name: transport into the mitochondria (carnitine)
reversible: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000185
kinetic law: MODEL1310110023#
product: MODEL1310110023#
fast: false

metaR ACCOAtn
type: Reaction
name: acetyl-CoA transport, nuclear
is described by: ECO:0000000
reactant: MODEL1310110023#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110023#
fast: false
product: MODEL1310110023#

metaR r1564
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#

metaM mi134p c
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58414
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243
is: SBO:0000247
is: HMDB01143

metaM hxan e
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
is: HMDB00157
constant: false
is: SBO:0000247
name: hypoxanthine
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17368

metaM retn c
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
constant: false
name: all-trans-retinoate
is: HMDB01852
boundary condition: false
is: CHEBI:35291
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110023#_29a642aa_1c1e_4631_a6ce_8b507c585e02
initial amount: NaN
is: Q8N3T1
name: GALNTL2
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:117248
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_97935e42_4e52_422f_ab58_a5ab9c8f8f7e
name: _AA614647_1_c
type: Species
is encoded by: hsa:AA614647
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false

metaR B3GALT5g
type: Reaction
is: SBO:0000176
product: MODEL1310110023#
kinetic law: MODEL1310110023#
fast: false
reversible: false
modifier: MODEL1310110023#
name: Beta-1,3-galactosyltransferase 5
reactant: MODEL1310110023#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10317.4) or (10317.1) or (10317.3) or (10317.2) or (10317.5) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaM arab L e
is: CHEBI:30849
type: Species
initial concentration: 1.0
notes: FORMULA: C5H10O5 CHARGE: 0
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB00646
boundary condition: false
name: L-arabinose
constant: false

metaR r1565
reactant: MODEL1310110023#
reversible: true
kinetic law: MODEL1310110023#
is described by: ECO:0000000
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110023#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110023#_e93a106b_3136_49fd_a9e9_dc24202e60bf
is: SBO:0000252
is encoded by: hsa:AA664770
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false
name: _AA664770_1_m

metaR TRDRm
is version of: http://identifiers.org/ec-code/1.8.1.9
reversible: false
reactant: MODEL1310110023#
modifier: MODEL1310110023#
is described by: ECO:0000269
name: thioredoxin reductase (NADPH)
type: Reaction
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (114112.1) or (10587.1) or (10587.3) or (10587.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:10215850,PMID:11259642,PMID:12705894 NOTES:NCD
kinetic law: MODEL1310110023#
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110023#_9083fc7f_4003_4f9a_a25a_5e4fb22ebea5
name: MTMR6
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: Q9Y217
is encoded by: hsa:9107
boundary condition: true
has only substance units: false
constant: false

metaR HSD3B11
is version of: http://identifiers.org/ec-code/1.1.1.145
fast: false
name: 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I
is: SBO:0000176
notes: GENE_ASSOCIATION: (3283.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:16023337 NOTES:progesterone prduction measured after the incubation of human granulosa cells with pregnenolone
is described by: ECO:0000134
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
type: Reaction
product: MODEL1310110023#
reversible: false
reactant: MODEL1310110023#

metaM hpdcacrn m
is: HMDB06210
initial amount: NaN
notes: FORMULA: C24H47NO4 CHARGE: 0 INCHI: InChI=1/C24H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24(28)29-22(20-23(26)27)21-25(2,3)4/h22H,5-21H2,1-4H3
is: SBO:0000247
constant: false
type: Species
name: heptadecanoyl carnitine
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaR r1566
kinetic law: MODEL1310110023#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
product: MODEL1310110023#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110023#_dd5fdebb_ae8a_4336_8a92_d2cb6ddeb752
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:10229
is: Q99807
is: SBO:0000252
constant: false
name: COQ7
boundary condition: true
has only substance units: false

metaM ps hs m
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:18303
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
boundary condition: false
name: ps_hs[m]
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_fed89b21_d163_4ffb_856a_309bce90dcde
is: E5KS60
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8803
is: SBO:0000252
name: SUCLA2
type: Species
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_fd6fe207_706c_48d3_9b94_363b0295082e
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:10588
initial concentration: NaN
is: SBO:0000252
constant: false
is: P49914
name: MTHFS
boundary condition: true

metaR DMATT
name: dimethylallyltranstransferase
fast: false
kinetic law: MODEL1310110023#
reversible: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (9453.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 2 AUTHORS: PMID:17477828,PMID:17477829 NOTES:Human Y/N: Y
product: MODEL1310110023#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.5.1.1
reactant: MODEL1310110023#
modifier: MODEL1310110023#

metaR FAOXC226C225m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)m
type: Reaction

metaR ALAASNNaEx
modifier: MODEL1310110023#
fast: false
reversible: false
is: SBO:0000185
product: MODEL1310110023#
name: L-alanine/L-asparagine Na-dependent exchange (Ala-L in)
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110023#

metaR CYOR u10m
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
fast: false
reversible: false
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.2.1.3
is version of: http://identifiers.org/ec-code/3.5.1.92
is: SBO:0000185
type: Reaction
product: MODEL1310110023#
modifier: MODEL1310110023#
is described by: ECO:0000134
name: ubiquinol-6 cytochrome c reductase, Complex III

metaR r0249
is described by: ECO:0000000
modifier: MODEL1310110023#
name: D-Ribose-5-phosphate ketol-isomerase Pentose phosphate pathway EC:5.3.1.6
product: MODEL1310110023#
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.7.12
notes: GENE_ASSOCIATION: (2592.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: PMID:14690456,PMID:14988808,PMID:15234337,PMID:2843500 NOTES:
reversible: true
is: SBO:0000176
type: Reaction
reactant: MODEL1310110023#
fast: false

metaR FAOXC10C10OHm
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->OHC10)m
type: Reaction

metaR FAOXC102C81m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)m
type: Reaction

metaR 2HBt2
is: SBO:0000185
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
is described by: ECO:0000269
fast: false
product: MODEL1310110023#
modifier: MODEL1310110023#
reversible: true
name: 2-hydroxybutyrate cotransport with proton
type: Reaction

metaM arab L c
constant: false
is: CHEBI:30849
notes: FORMULA: C5H10O5 CHARGE: 0
type: Species
initial concentration: 1.0
has only substance units: false
name: L-arabinose
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB00646

metaR r1567
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110023#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_a38bd09a_0fb1_46fc_8278_29eebb0e321e
is encoded by: hsa:206
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
name: _206_1_c
boundary condition: true

metaR EX spc hs LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: sphingosylphosphorylcholine (homo sapiens) exchange
type: Reaction

metaM arachd r
constant: false
type: Species
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
is: HMDB01043
initial concentration: 1.0
is: CHEBI:32395
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
name: arachidonate

metaM 4abutn m
is: HMDB01080
name: 4-ammoniobutanal
is: CHEBI:58264
constant: false
type: Species
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false

metaR ENGASEly
is: SBO:0000176
reactant: MODEL1310110023#
product: MODEL1310110023#
reversible: false
type: Reaction
name: endo-beta-N-acetylglucosaminidase, lysosomal
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD

MODEL1310110023#
species: metaM mpdol U c
species: metaM 10fthf c
species: metaM HC02023 r
species: metaM acgam1p c
species: metaM prostge1 e
species: metaM eipencoa x
species: metaM 3mob e
name: GUCY1B2:GUCY1A2
species: metaM ksi pre28 g
species: metaM gal c
species: metaM crn c
species: metaM dec24dicoa m
species: metaM cholp c
species: metaM ppcoa m
species: metaM ksi deg14 l
species: metaM ksii core2 pre1 g
species: metaM 2docopencoa x
species: metaM uacgam g
type: Species
species: metaM 3snpyr m
species: metaM msa m
species: metaM dece3coa m
species: metaM 2octpencoa m
species: metaM malcoa c
species: metaM occoa c
species: metaM retinal c
species: metaM dcacoa m
species: metaM atp r
species: metaM HC01403 m
species: metaM 1p3h5c c
name: HEXA:HEXB
species: metaM fdp c
species: metaM 4hphac c
species: metaM HC01409 m
species: metaM 4ppcys m
species: metaM fad e
species: metaM pi n
species: metaM mlthf m
species: metaM arachd e
name: GLB1:CTSA
species: metaM tyr L m
species: metaM 56dura c
species: metaM 4nphsf c
species: metaM s2l2n2m2mn l
species: metaM vacc e
species: metaM inost e
species: metaM dd5ecoa m
species: metaM f6p c
species: metaM pail5p hs n
species: metaM pail45p hs n
species: metaM ctp n
species: metaM udpg r
species: metaM urate c
species: metaM dmpp c
species: metaM 2mop c
species: metaM cytd c
multipler: 2.77777777777778E-4
species: metaM docohexcoa m
species: metaM aacoa m
species: metaM ump n
species: metaM air c
species: metaM glcur e
species: metaM pmtcoa r
species: metaM retinol 9 cis c
species: metaM orn e
species: metaM thp2c x
species: metaM formcoa c
species: metaM CE2418 m
species: metaM hpdcacrn c
species: metaM 2hexdtricoa m
species: metaM n2m2nmasn l
species: metaM hepcoa m
species: metaM nadph x
species: metaM ksi pre25 g
species: metaM lnlnca e
species: metaM xyl D c
species: metaM pap g
species: metaM fald c
species: metaM crn r
stoichiometry: 0.005829

metaR FBA
reversible: true
product: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (230.1) or (229.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:12626877,PMID:6765112 NOTES:6765112 - fluorescence of presence in human brain
is: SBO:0000176
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.2.13
modifier: MODEL1310110023#
is described by: ECO:0000134
kinetic law: MODEL1310110023#
name: fructose-bisphosphate aldolase

metaM dgchol c
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
initial concentration: 1.0
boundary condition: false
is: HMDB00637
name: glycochenodeoxycholate
has only substance units: false
is: SBO:0000247
is: CHEBI:36252
type: Species
constant: false
initial amount: NaN

metaM HC01434 m
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
initial amount: NaN
constant: false
is: SBO:0000247
name: oxalatosuccinate(3-)
initial concentration: 1.0
has only substance units: false
is: CHEBI:58931
type: Species
boundary condition: false

metaR r1560
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110023#
is described by: ECO:0000000
reversible: true
type: Reaction
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
fast: false

metaR PPPGOm
product: MODEL1310110023#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.4
modifier: MODEL1310110023#
fast: false
name: protoporphyrinogen oxidase, mitochondrial
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (5498.1) SUBSYSTEM: Heme synthesis EC Number: 1.3.3.4 Confidence Level: 2 AUTHORS: PMID:8771201 NOTES:NCD
is: SBO:0000176
reversible: false
is described by: ECO:0000304

metaR ADNK1
reversible: false
kinetic law: MODEL1310110023#
fast: false
name: adenosine kinase
is version of: http://identifiers.org/ec-code/2.7.1.20
type: Reaction
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (132.1) or (132.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110023#
modifier: MODEL1310110023#
is described by: ECO:0000269
is: SBO:0000176

metaR DHAAt1r
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6515.1) or (6513.1) or (6517.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:15705056,PMID:2656669,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
product: MODEL1310110023#
type: Reaction
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
reversible: true
name: dehydroascorbate transport (uniport)
reactant: MODEL1310110023#
is: SBO:0000185
fast: false

metaR FAOXC184C164m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_c59d93b9_351c_4819_8ba6_024f4db27b53
is: P11182
constant: false
is: SBO:0000252
initial concentration: NaN
name: DBT
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:1629
type: Species

metaM 6a2ohxnt x
is: SBO:0000247
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-4-2-1-3-5(8)6(9)10/h1-4,7H2,(H,9,10) EHMN_ABBREVIATION: C03239
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:17534
name: 6-amino-2-oxohexanoic acid
boundary condition: false
is: HMDB12151

metaR S6T17g
modifier: MODEL1310110023#
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
reversible: false
kinetic law: MODEL1310110023#
product: MODEL1310110023#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110023#
type: Reaction

metaM dmnoncoa m
name: 4,8 dimethylnonanoyl-CoA
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
has only substance units: false
boundary condition: false
constant: false
is: HMDB11604
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_4055989b_4d71_47b8_a188_280fc3489c3f
constant: false
boundary condition: true
name: NEU1
is: Q99519
is encoded by: hsa:4758
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR r1561
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110023#
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110023#

metaR EX gly LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Glycine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_bab6297e_fe1f_4307_9640_5b41a6d6119d
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:79053
initial amount: NaN
name: ALG8
is: A6NDW6

metaM CE5101 m
is: CHEBI:57795
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
is: SBO:0000247
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101
type: Species
has only substance units: false
constant: false

metaR NDP8ex
name: nucleoside-diphosphatase (UTP), extracellular
is version of: http://identifiers.org/ec-code/3.6.1.6
product: MODEL1310110023#
type: Reaction
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
reversible: false
is: SBO:0000176
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
fast: false
is described by: ECO:0000269

metaR FACOAL180i
modifier: MODEL1310110023#
is described by: ECO:0000269
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: false
fast: false
name: C180 fatty acid activation
notes: GENE_ASSOCIATION: (22305.2) or (2181.2) or (51703.1) or (2181.1) or (2180.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
is: SBO:0000176
reactant: MODEL1310110023#
type: Reaction
product: MODEL1310110023#

metaR MG3er
fast: false
type: Reaction
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
product: MODEL1310110023#
reversible: false
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
is: SBO:0000176
kinetic law: MODEL1310110023#
is described by: ECO:0000000

metaR r0464
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
type: Reaction
fast: false
reversible: true
product: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000176
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:

metaM amet c
is: HMDB01185
constant: false
initial concentration: 1.0
is: C00019
initial amount: NaN
has only substance units: false
name: S-Adenosyl-L-methionine
is: SBO:0000247
boundary condition: false
is: CHEBI:15414
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
type: Species

metaR r1562
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110023#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110023#
is: SBO:0000185

metaR NACHEX1ly
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
product: MODEL1310110023#
is described by: ECO:0000000
modifier: MODEL1310110023#
reactant: MODEL1310110023#
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
fast: false
kinetic law: MODEL1310110023#
is: SBO:0000176

metaR RPI
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
fast: false
type: Reaction
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
reactant: MODEL1310110023#
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/5.3.1.6
is: SBO:0000176
name: ribose-5-phosphate isomerase

http://identifiers.org/biomodels.db/MODEL1310110023#_73fc0aa2_a934_4308_9924_9f03752fc7a4
boundary condition: true
is: Q6IBB5
has only substance units: false
name: NDUFA1
type: Species
is encoded by: hsa:4694
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_03dfe6a5_1bce_4465_860c_53a847169264
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaR COQ5m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10777520,PMID:1965190,PMID:7380842 NOTES:_2.1.1.- IT
fast: false
reversible: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110023#
name: Ubiquinone biosynthesis methyltransferase COQ5

metaR PMEVKc
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (10654.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added to substrate for elemental balancing.
is version of: http://identifiers.org/ec-code/2.7.4.2
kinetic law: MODEL1310110023#
name: phosphomevalonate kinase, cytosol
is described by: ECO:0000134
type: Reaction
is: SBO:0000176
reversible: false
fast: false
product: MODEL1310110023#
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_d8b970a4_dd23_4518_af56_58ae6b62a89c
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:80347
initial concentration: NaN
is: SBO:0000252
is: Q13057
type: Species
name: COASY

metaM hxan c
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
initial amount: NaN
type: Species
is: C00262
name: Hypoxanthine
is: HMDB00157
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:17368
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110023#_d7c1767b_8f23_430b_91d4_87c6b820e21e
is encoded by: hsa:6392
boundary condition: true
name: SDHD
constant: false
type: Species
is: SBO:0000252
is: O14521
initial amount: NaN
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_fd60a105_64d6_4a3c_b860_a34ea8671511
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:57379
boundary condition: true
constant: false
type: Species
initial concentration: NaN
is: Q546Y9
name: AICDA

metaR EX dopa LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine exchange
type: Reaction

metaM btn c
is: SBO:0000247
name: Biotin
initial concentration: 1.0
type: Species
constant: false
is: HMDB00030
has only substance units: false
is: C00120
is: CHEBI:3420
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H15N2O3S CHARGE: -1

metaM CE0849 m
is: SBO:0000247
boundary condition: false
constant: false
name: cis,cis-palmito-7,10-dienoyl-CoA
type: Species
is: CHEBI:57795
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849
initial amount: NaN

metaR r0463
type: Reaction
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:
reactant: MODEL1310110023#
name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10
is described by: ECO:0000000
fast: false
is: SBO:0000176
product: MODEL1310110023#
reversible: true

metaR HISTAtu
name: Histamine uniport
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
reversible: true
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
modifier: MODEL1310110023#

metaR ATPH1e
reactant: MODEL1310110023#
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.6
fast: false
notes: GENE_ASSOCIATION: (954.1) or (954.2) or (953.1) or (956.1) or (955.1) or (957.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.5 Confidence Level: 4 AUTHORS: PMID:8955160,PMID:9676430 NOTES:IT
kinetic law: MODEL1310110023#
name: ATP diphosphohydrolase
is version of: http://identifiers.org/ec-code/3.6.1.5
type: Reaction
modifier: MODEL1310110023#
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110023#

metaR r1563
reactant: MODEL1310110023#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110023#
type: Reaction
product: MODEL1310110023#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM Ser Gly Ala X Gly l
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:36005
is: HMDB02183
name: protein-linked serine residue (glycosaminoglycan attachment site)
type: Species
constant: false
notes: FORMULA: XH CHARGE: 0

metaM dhf m
name: dihydrofolate(2-)
is: SBO:0000247
type: Species
is: HMDB01056
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
constant: false
initial amount: NaN
is: CHEBI:57451

metaR PYDAMK
reactant: MODEL1310110023#
is: SBO:0000176
name: pyridoxamine kinase
is version of: http://identifiers.org/ec-code/2.7.1.35
fast: false
reversible: false
kinetic law: MODEL1310110023#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8566.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110023#
type: Reaction
product: MODEL1310110023#

metaR G6PPer
product: MODEL1310110023#
type: Reaction
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (57818.1) or (2538.1) or (92579.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 3.1.3.9 Confidence Level: 4 AUTHORS: PMID:10078553,PMID:11297555,PMID:12370122,PMID:12965222,PMID:13129915,PMID:15044018,PMID:8211187,PMID:8407995,PMID:9497333 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110023#
reactant: MODEL1310110023#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.9
name: glucose-6-phosphate phosphatase, edoplasmic reticular
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_56640176_3b13_414c_af74_83c641475d08
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: B1AK53
constant: false
type: Species
is encoded by: hsa:83715
boundary condition: true
name: ESPN

http://identifiers.org/biomodels.db/MODEL1310110023#_1357d953_86c2_45da_a6d6_45855d488613
name: CHST2
is: Q9Y4C5
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:9435
constant: false
type: Species
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_1bc5d5f5_b1f8_4979_b6bf_a705521c1b69
boundary condition: true
is: SBO:0000252
type: Species
name: NME7
initial concentration: NaN
constant: false
is: Q9Y5B8
has only substance units: false
is encoded by: hsa:29922
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_5943e22f_0a15_44b8_8ba1_2f09f2028745
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:9963
is: SBO:0000252
boundary condition: true
name: SLC23A1
constant: false
initial concentration: NaN

metaR DM anth
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

metaM tddedicoa m
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
name: trans3,6dodecadienoylcoa
boundary condition: false
is: http://identifiers.org/pubchem.compound/5280771
type: Species
initial concentration: 1.0

metaR GALASE1ly
modifier: MODEL1310110023#
name: beta-galactosidase, lysosomal
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110023#
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18

http://identifiers.org/biomodels.db/MODEL1310110023#_946bc43b_3e5e_47e8_a76f_47e1f8085b4c
initial concentration: NaN
boundary condition: true
is: Q71UM8
constant: false
initial amount: NaN
name: ADCY2
type: Species
is encoded by: hsa:108
has only substance units: false
is: SBO:0000252

metaM 34hpp c
name: 3-(4-hydroxyphenyl)pyruvate
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
is: CHEBI:36242
is: HMDB00707

http://identifiers.org/biomodels.db/MODEL1310110023#_a7ad5d45_1bb0_4f66_92bd_0200cc7f9965
is encoded by: hsa:284111
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q86YT5
type: Species
name: SLC13A5

metaR C14STRr
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.3.1.70
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
is: SBO:0000176
type: Reaction
product: MODEL1310110023#
name: C-14 sterol reductase
reactant: MODEL1310110023#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ

metaR GLCter
kinetic law: MODEL1310110023#
name: glucose transport, endoplasmic reticulum
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD
reactant: MODEL1310110023#
product: MODEL1310110023#

metaR SRTNtu
type: Reaction
modifier: MODEL1310110023#
fast: false
name: Serotonin uniport
product: MODEL1310110023#
kinetic law: MODEL1310110023#
reversible: true
is: SBO:0000185
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (6580.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
is described by: ECO:0000269

metaR GALASE8ly
name: beta-galactosidase, lysosomal
kinetic law: MODEL1310110023#
is described by: ECO:0000000
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
modifier: MODEL1310110023#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaR DNDPt17m
kinetic law: MODEL1310110023#
fast: false
name: dUDP transport via dCDP antiport
type: Reaction
is described by: ECO:0000269
reversible: false
product: MODEL1310110023#
reactant: MODEL1310110023#
is: SBO:0000185
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

metaM gmp e
name: GMP(3-)
initial concentration: 1.0
is: CHEBI:58115
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB01397
constant: false
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144

http://identifiers.org/biomodels.db/MODEL1310110023#_4b7c8c6e_7002_4cf4_a1f7_2293bf6c78c2
initial concentration: NaN
name: RRM1
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
is: P23921
has only substance units: false
is encoded by: hsa:6240
boundary condition: true

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

metaR r0021
modifier: MODEL1310110023#
reactant: MODEL1310110023#
type: Reaction
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
product: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
fast: false
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.6.1.5

metaR LNELDCCPT2
reversible: false
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
modifier: MODEL1310110023#
name: carnitine transferase
type: Reaction

metaR r0394
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
kinetic law: MODEL1310110023#
is: SBO:0000176
type: Reaction
reversible: true
product: MODEL1310110023#
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
reactant: MODEL1310110023#
fast: false
is described by: ECO:0000000

metaM 2hb e
initial concentration: 1.0
has only substance units: false
is: CHEBI:1148
initial amount: NaN
is: HMDB00008
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
boundary condition: false
constant: false
type: Species
is: SBO:0000247
name: 2-Hydroxybutyrate

metaM ade c
name: Adenine
is: CHEBI:16708
type: Species
initial amount: NaN
is: HMDB00034
has only substance units: false
boundary condition: false
is: C00147
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
constant: false
initial concentration: 1.0
is: SBO:0000247

metaR r1620
type: Reaction
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110023#
is: SBO:0000185
fast: false
reversible: true

metaR EX fe2 LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_fe2(u)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_68344fa9_789a_49c7_a2db_4b204ad2635e
is: P42126
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:1632
name: ECI1
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110023#_f00fbdc1_486a_44a5_8159_6d3d9acaa2f3
name: PDE4A
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is: P27815
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:5141

metaR r2308
reactant: MODEL1310110023#
product: MODEL1310110023#
kinetic law: MODEL1310110023#
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:

metaR EX acnacngalgbside hs LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: disialyl galactosylgloboside (homo sapiens) exchange
type: Reaction

metaR LNELDCCPT1
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000269
modifier: MODEL1310110023#
fast: false
type: Reaction
is: SBO:0000176
name: carnitine O-palmitoyltransferase
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.3.1.21

metaR r0022
fast: false
type: Reaction
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.8.1.7
is: SBO:0000176
reactant: MODEL1310110023#
product: MODEL1310110023#
modifier: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_7e1246a6_2fdf_41e3_883e_448428527ddd
type: Species
is: SBO:0000252
is encoded by: hsa:10993
name: SDS
is: P20132
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

metaM 4ppan c
boundary condition: false
initial amount: NaN
has only substance units: false
name: D-4'-Phosphopantothenate
is: SBO:0000247
initial concentration: 1.0
is: C03492
is: CHEBI:10986
constant: false
is: HMDB01016
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
type: Species

metaR r0242
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
fast: false
type: Reaction
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
product: MODEL1310110023#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.1

metaM retinal cis 9 c
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
is: CHEBI:17898
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
is: HMDB01358
is: SBO:0000247
boundary condition: false
has only substance units: false
name: all-trans-retinal

metaR G6PDH2rer
reactant: MODEL1310110023#
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum
modifier: MODEL1310110023#
reversible: true
kinetic law: MODEL1310110023#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.47
is: SBO:0000176
product: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:NCD

metaM guln r
boundary condition: false
type: Species
is: CHEBI:13115
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
initial amount: NaN
is: SBO:0000247
name: L-gulonate
constant: false
initial concentration: 1.0
is: HMDB03290
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_343a469b_33f0_434f_8924_a378848f2f43
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:1103
constant: false
name: CHAT
is: D3DX95
has only substance units: false

metaR ASNNm
reversible: false
type: Reaction
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.5.1.1
reactant: MODEL1310110023#
is described by: ECO:0000254
is: SBO:0000176
kinetic law: MODEL1310110023#
name: L-asparaginase (mitochondrial)
fast: false
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (80150.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.1 Confidence Level: 2 AUTHORS: PMID:11984834 NOTES:PMID: 11984834 (denotes it as potentially mitochondrial) mm

metaM arachdcoa c
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
is: CHEBI:57368
is: HMDB06523
name: arachidonoyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110023#_ee563145_c16c_4ca9_80ea_90c40f236652
initial concentration: NaN
type: Species
boundary condition: true
is: P20594
has only substance units: false
is encoded by: hsa:4882
name: NPR2
constant: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110023#_e3ba10e8_b536_48bb_a4b7_292ea55153bf
is encoded by: hsa:1376
type: Species
name: CPT2
is: SBO:0000252
is: P23786
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN

metaR r2309
product: MODEL1310110023#
is: SBO:0000185
kinetic law: MODEL1310110023#
type: Reaction
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
fast: false
reversible: true

metaM gmp c
type: Species
name: GMP
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58115
is: C00144
constant: false
initial amount: NaN
has only substance units: false
is: HMDB01397

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

metaM estradiol e
type: Species
is: CHEBI:16469
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
name: estradiol
constant: false
is: HMDB00151
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951

metaR GLCt4
reversible: true
modifier: MODEL1310110023#
type: Reaction
name: glucose transport via sodium symport
fast: false
is: SBO:0000185
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
product: MODEL1310110023#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD

metaM 2hb c
name: 2-Hydroxybutyrate
type: Species
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
boundary condition: false
is: CHEBI:1148
is: HMDB00008
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false

metaR GGH 6THFe
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
is described by: ECO:0000000
reversible: false
product: MODEL1310110023#
fast: false
type: Reaction
name: Gamma-glutamyl hydrolase (6THF), extracellular
is: SBO:0000176
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.4.19.9

metaM fum m
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:29806
initial amount: NaN
is: C00122
name: Fumarate
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
has only substance units: false
constant: false
is: HMDB00134
boundary condition: false
type: Species

metaM ribflv c
type: Species
is: CHEBI:3554
boundary condition: false
notes: FORMULA: C17H20N4O6 CHARGE: 0
constant: false
has only substance units: false
is: HMDB00244
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: C00255
name: Riboflavin

http://identifiers.org/biomodels.db/MODEL1310110023#_990c5f5b_2f7c_46ea_8ebd_98f84f8054e6
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is: Q9NS18
initial concentration: NaN
is encoded by: hsa:51022
name: GLRX2

metaM dhbpt c
initial amount: NaN
type: Species
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
is: CHEBI:20680
boundary condition: false
is: HMDB00038
name: 6,7-dihydrobiopterin
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaR GTMLTe
fast: false
notes: GENE_ASSOCIATION: (2679.1) or (2678.1) or (2678.3) or (2678.2) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:15469854 NOTES:NCD SAB e see Disussion section of PMID 15469854
type: Reaction
modifier: MODEL1310110023#
name: g-glutamyltransferase (e)
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.3.2.2
reversible: false

metaR r1569
reactant: MODEL1310110023#
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110023#
product: MODEL1310110023#
is: SBO:0000185

metaR r1622
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110023#
reversible: true
fast: false
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110023#
type: Reaction
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110023#

metaR NADPHtru
is: SBO:0000185
type: Reaction
fast: false
name: NADPH transporter, endoplasmic reticulum
is described by: ECO:0000000
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
reversible: false
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#

metaM HC02205 e
is: CHEBI:28099
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: prostaglandin-b2
boundary condition: false

metaR r0393
is: SBO:0000176
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.1.74
type: Reaction
fast: false
modifier: MODEL1310110023#
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
is described by: ECO:0000000
kinetic law: MODEL1310110023#
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110023#_48379ca1_765f_441b_8d2c_e65ddfef2b03
has only substance units: false
is encoded by: hsa:23556
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is: O95427
type: Species
name: PIGN

http://identifiers.org/biomodels.db/MODEL1310110023#_05554338_fa04_4fd5_95f5_7484e40826a1
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:285973
is: Q674R7
has only substance units: false
name: ATG9B
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_f35e7ebc_2bd5_4b07_9723_85610192d0a6
initial amount: NaN
type: Species
is encoded by: hsa:11226
boundary condition: true
constant: false
name: GALNT6
has only substance units: false
is: Q8NCL4
is: SBO:0000252
initial concentration: NaN

metaR PROSTGE2t2
name: prostaglandin uniport
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
type: Reaction
reactant: MODEL1310110023#
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110023#
product: MODEL1310110023#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_da3c7621_4b69_4a47_a878_88e44752e0c0
type: Species
constant: false
is encoded by: hsa:51079
name: NDUFA13
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: Q9P0J0
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_6a2596fa_20ed_4c5f_9cda_c23312187459
is encoded by: hsa:54539
type: Species
is: SBO:0000252
is: Q9NX14
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: NDUFB11
constant: false
has only substance units: false

metaR r1568
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110023#
product: MODEL1310110023#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110023#
fast: false

metaR r1621
fast: false
type: Reaction
is: SBO:0000185
reversible: true
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110023#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
product: MODEL1310110023#
modifier: MODEL1310110023#

metaR AG13T6g
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.4.1.149
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110023#
type: Reaction
fast: false
reversible: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110023#

metaM gullac c
is: HMDB03466
notes: FORMULA: C6H10O6 CHARGE: 0 INCHI: InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3+,4-,5+/m0/s1
type: Species
is: SBO:0000247
constant: false
name: L-gulono-1,4-lactone
has only substance units: false
initial concentration: 1.0
is: CHEBI:17587
initial amount: NaN
boundary condition: false

metaM pro L m
has only substance units: false
type: Species
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:17203
is: HMDB00162
is: SBO:0000247
name: L-proline
initial amount: NaN

metaR r0245
modifier: MODEL1310110023#
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.3
reversible: true
is described by: ECO:0000000
product: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
is: SBO:0000176
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_71f0810a_d77b_414d_af0d_0c29da591d53
type: Species
is: SBO:0000252
is: Q9BYZ2
initial concentration: NaN
name: LDHAL6B
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:92483

http://identifiers.org/biomodels.db/MODEL1310110023#_d4f8b53f_551a_4e86_89cb_773c1b76ed77
is: O95864
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:9415
has only substance units: false
initial amount: NaN
type: Species
name: FADS2
is: SBO:0000252

metaR r0390
reversible: true
kinetic law: MODEL1310110023#
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
fast: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000000

metaM crvnc c
constant: false
boundary condition: false
is: CHEBI:36005
has only substance units: false
initial amount: NaN
notes: FORMULA: C22H31O2 CHARGE: -1
initial concentration: 1.0
name: cervonic acid, C22:6 n-3
is: SBO:0000247
type: Species
is: HMDB02183

metaM ocdececrn c
constant: false
initial amount: NaN
name: 11-octadecenoyl carnitine
has only substance units: false
is: SBO:0000247
is: HMDB06351
notes: FORMULA: C25H47NO4 CHARGE: 0
initial concentration: 1.0
boundary condition: false
type: Species

metaR Ser Thrtg
name: Ser/Thr transport (from golgi to lysosome)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
reactant: MODEL1310110023#
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110023#
product: MODEL1310110023#

metaM ribflv e
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C17H20N4O6 CHARGE: 0
is: CHEBI:3554
is: HMDB00244
initial amount: NaN
name: Riboflavin
boundary condition: false
constant: false
is: C00255
initial concentration: 1.0

metaM 34hpp e
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
constant: false
name: 3-(4-hydroxyphenyl)pyruvate
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:36242
is: HMDB00707
type: Species

metaR r1624
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110023#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110023#
reversible: true
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110023#
modifier: MODEL1310110023#

metaM tridcoa m
has only substance units: false
notes: FORMULA: C34H56N7O17P3S CHARGE: -4
boundary condition: false
is: HMDB13109
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
name: tridecanoylcoa

http://identifiers.org/biomodels.db/MODEL1310110023#_704674c3_c98f_4ba7_b0ed_192172fd7fba
is: P18283
constant: false
is: SBO:0000252
type: Species
name: GPX2
is encoded by: hsa:2877
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false

metaM HC02205 c
constant: false
is: CHEBI:28099
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
name: prostaglandin-b2
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_ab6b1f7e_8657_4c0b_b1a8_b63d4500b5a5
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
name: ACSS2
boundary condition: true
constant: false
is encoded by: hsa:55902
is: Q5QPH3

metaM gluala e
is: HMDB06248
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740
name: 5-L-Glutamyl-L-alanine
is: http://identifiers.org/pubchem.compound/6503
initial concentration: 1.0
is: C03740
is: SBO:0000247
type: Species
boundary condition: false

metaM ksi pre24 g
notes: FORMULA: C191H306N13O158S7X CHARGE: -8
is: HMDB00175
constant: false
boundary condition: false
is: C00130
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:58053
type: Species
name: keratan sulfate I biosynthesis, precursor 24

metaM air c
is: SBO:0000247
is: HMDB01235
boundary condition: false
type: Species
notes: FORMULA: C8H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01108 EHMN_ABBREVIATION: C03373
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole
constant: false
is: C03373
is: CHEBI:58592

metaR r0391
product: MODEL1310110023#
is: SBO:0000176
reactant: MODEL1310110023#
type: Reaction
kinetic law: MODEL1310110023#
fast: false
is described by: ECO:0000000
reversible: true
name: Nicotinate D-ribonucleotide:pyrophosphate phosphoribosyltransferase Nicotinate and nicotinamide metabolism EC:2.4.2.11
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 2.4.2.11 Confidence Level: 0 AUTHORS: PMID:17604275 NOTES:

metaM gmp g
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
boundary condition: false
type: Species
name: GMP(3-)
is: CHEBI:58115
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB01397

metaM forglu c
is: HMDB00854
notes: FORMULA: C6H8N2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00357 EHMN_ABBREVIATION: C00439
initial amount: NaN
has only substance units: false
type: Species
name: N-Formimidoyl-L-glutamate
constant: false
initial concentration: 1.0
boundary condition: false
is: C00439
is: SBO:0000247
is: CHEBI:18327

metaR RPEc
reactant: MODEL1310110023#
fast: false
name: ribulose 5-phosphate 3-epimerase
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
type: Reaction
is described by: ECO:0000134
product: MODEL1310110023#

metaR r1623
is: SBO:0000185
modifier: MODEL1310110023#
reactant: MODEL1310110023#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110023#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110023#
fast: false

metaR r0246
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
reactant: MODEL1310110023#
product: MODEL1310110023#
fast: false
kinetic law: MODEL1310110023#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.3
reversible: false
modifier: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_546fe020_e7aa_4e0b_8b7e_f6f992e5ff0b
is encoded by: hsa:100287639
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
name: _100287639_1_c
type: Species
initial concentration: NaN

metaR NACHEX8ly
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110023#
reversible: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110023#
reactant: MODEL1310110023#
type: Reaction
fast: false
kinetic law: MODEL1310110023#

metaR r1779
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
name: Y+LAT2 Utilized transport
reversible: false
fast: false
reactant: MODEL1310110023#
type: Reaction
is: SBO:0000185
product: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_710e0a1a_4bc6_4982_be23_8c6298f16e96
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:11238
name: CA5B
initial amount: NaN
initial concentration: NaN
is: Q9Y2D0
constant: false

metaR r1626
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110023#
is: SBO:0000185
product: MODEL1310110023#
fast: false
type: Reaction
reactant: MODEL1310110023#
modifier: MODEL1310110023#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR PROSTGD2t
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
type: Reaction
is described by: ECO:0000269
product: MODEL1310110023#
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
fast: false
name: prostaglandin transport via bicarbonate countertransport
reversible: true
is: SBO:0000185
reactant: MODEL1310110023#

metaM 3sala c
name: 3-Sulfino-L-alanine
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C3H5NO4S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:61085
type: Species
is: C00606

metaR TYRCBOX
reversible: false
kinetic law: MODEL1310110023#
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
is described by: ECO:0000134
is: SBO:0000176
reactant: MODEL1310110023#
fast: false
modifier: MODEL1310110023#
name: L-Tyrosine carboxy-lyase
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.1.28

metaR r0027
type: Reaction
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
kinetic law: MODEL1310110023#
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.14.13.39
is described by: ECO:0000000
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
modifier: MODEL1310110023#
fast: false
is: SBO:0000176
reversible: true

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

metaM crvnc e
boundary condition: false
type: Species
is: HMDB02183
is: SBO:0000247
constant: false
notes: FORMULA: C22H31O2 CHARGE: -1
has only substance units: false
initial amount: NaN
name: cervonic acid, C22:6 n-3
is: CHEBI:36005
initial concentration: 1.0

metaR EX ala D LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Alanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_dbb76751_e72d_4874_b7aa_f5a34ce7f7d0
type: Species
is: SBO:0000252
is encoded by: hsa:4882
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
name: NPR2
boundary condition: true

metaM Lkynr c
is: HMDB00684
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
is: CHEBI:16946
name: L-kynurenine
constant: false
is: SBO:0000247

metaM glx x
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
is: CHEBI:36655
has only substance units: false
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
is: HMDB00119
name: glyoxylate

metaM acgal1p c
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB06480
type: Species
name: N-Acetyl-D-galactosamine 1-phosphate
is: SBO:0000247
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6+,7-,8?/m1/s1
is: CHEBI:55404
initial concentration: 1.0
constant: false

metaR r2055
fast: false
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
product: MODEL1310110023#
modifier: MODEL1310110023#
reversible: false
reactant: MODEL1310110023#
type: Reaction
is: SBO:0000185

metaR r1625
modifier: MODEL1310110023#
reversible: true
kinetic law: MODEL1310110023#
is: SBO:0000185
product: MODEL1310110023#
fast: false
reactant: MODEL1310110023#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction

metaR G14T16g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
reversible: false
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.4.1.90
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_75b8320b_05ed_404e_84c7_cec656c415f2
initial amount: NaN
is encoded by: hsa:8704
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
name: B4GALT2
initial concentration: NaN
constant: false

metaR r0028
type: Reaction
reversible: false
kinetic law: MODEL1310110023#
fast: false
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:11278936 NOTES:
is described by: ECO:0000000
name: ATP pyrophosphohydrolase Purine metabolism EC:3.6.1.5
is: SBO:0000176
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_1fab686a_21f2_4570_9af4_4e6a45670879
initial amount: NaN
is: SBO:0000252
name: HADH
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:3033
is: Q16836
constant: false

metaM pail hs c
name: 1-phosphatidyl-1D-myo-inositol(1-)
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
has only substance units: false
initial concentration: 1.0
is: CHEBI:57880
constant: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110023#_5613308b_f60b_4699_a5d9_0563e93121ba
type: Species
name: ALG8
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:79053
is: SBO:0000252
is: Q9BVK2
boundary condition: true

metaR r0173
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110023#
is: SBO:0000176
name: (S)-Lactate:NAD+ oxidoreductase Glycolysis / Gluconeogenesis / Pyruvate metabolism EC:1.1.1.27
is version of: http://identifiers.org/ec-code/3.6.1.19
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (3704.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:12042361,PMID:17045662,PMID:7449128,PMID:9927705 NOTES:
type: Reaction
reversible: true
reactant: MODEL1310110023#
product: MODEL1310110023#

metaM dgchol x
has only substance units: false
is: CHEBI:36252
is: HMDB00637
type: Species
is: SBO:0000247
constant: false
name: glycochenodeoxycholate
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_4b89ee33_1709_4042_a8e8_3cb6904f740b
is: Q92781
name: RDH5
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:5959
constant: false

metaM cholcoa c
is: CHEBI:57373
type: Species
is: HMDB01374
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
boundary condition: false
initial amount: NaN
name: choloyl-CoA(4-)
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110023#_29584ce8_cff4_487e_990b_4e90f7dbdf21
name: SLC25A4
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
type: Species
is: P12235
has only substance units: false
is encoded by: hsa:291

http://identifiers.org/biomodels.db/MODEL1310110023#_d6b242c6_d895_4072_9a02_2a5f5728f56c
has only substance units: false
is: Q86U05
name: SLC7A8
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:23428
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_0d218cea_12ce_4e02_9eef_329a8af5f06d
is encoded by: hsa:34
type: Species
initial concentration: NaN
initial amount: NaN
is: P11310
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
name: ACADM

metaR r1628
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reactant: MODEL1310110023#
fast: false
product: MODEL1310110023#
kinetic law: MODEL1310110023#
reversible: true

metaR HSAT3ly
name: heparan-glucosaminide N-acetyltransferase, lysosomal
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110023#
fast: false
reactant: MODEL1310110023#
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
is described by: ECO:0000000
type: Reaction

metaR 4HGLSDm
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.12
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
is described by: ECO:0000212
modifier: MODEL1310110023#
fast: false
name: L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial

metaR AHEXASEly
is described by: ECO:0000000
kinetic law: MODEL1310110023#
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
type: Reaction
reactant: MODEL1310110023#
modifier: MODEL1310110023#
product: MODEL1310110023#
reversible: false
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
fast: false

metaM retn r
constant: false
boundary condition: false
is: CHEBI:35291
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
is: HMDB01852
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: all-trans-retinoate

metaR HESTRATRIOLte
kinetic law: MODEL1310110023#
name: hydroxylated estrogen derivative transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, hydroxylated (inactivated) estrogen derivative needs to be exported NJ
reversible: true
type: Reaction
reactant: MODEL1310110023#
product: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000185

metaM 4hbz m
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:17879
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C7H5O3 CHARGE: -1 INCHI: InChI=1S/C7H6O3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H,(H,9,10)/p-1
name: 4-hydroxybenzoate
initial concentration: 1.0
is: HMDB00500

http://identifiers.org/biomodels.db/MODEL1310110023#_1606921a_d1a9_4df2_b312_311001171300
name: PKM2
is encoded by: hsa:5315
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
is: P14618
boundary condition: true
type: Species
initial concentration: NaN

metaM mercplac c
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
name: 3-Mercaptolactate
is: C05823
is: http://identifiers.org/pubchem.compound/8118
has only substance units: false
notes: FORMULA: C3H5O3S CHARGE: -1 INCHI: InChI=1/C3H6O3S/c4-2(1-7)3(5)6/h2,4,7H,1H2,(H,5,6) EHMN_ABBREVIATION: C05823
boundary condition: false
is: HMDB02127
is: SBO:0000247

metaM estradiol c
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
is: SBO:0000247
constant: false
has only substance units: false
name: estradiol
is: HMDB00151
type: Species
is: CHEBI:16469
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaM fum c
boundary condition: false
is: HMDB00134
is: C00122
constant: false
initial concentration: 1.0
name: Fumarate
type: Species
is: CHEBI:29806
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
has only substance units: false

metaR r1627
is: SBO:0000185
reversible: true
reactant: MODEL1310110023#
fast: false
product: MODEL1310110023#
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_9e504f55_339d_49f4_94d5_1d07cd634cd8
type: Species
boundary condition: true
is encoded by: hsa:5332
is: SBO:0000252
name: PLCB4
constant: false
is: Q15147
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM 2mp2coa m
is: HMDB01011
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
initial concentration: 1.0
is: SBO:0000247
name: 2-Methylprop-2-enoyl-CoA
type: Species
is: CHEBI:27754
boundary condition: false

metaR EX chol LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Choline
type: Reaction

metaR RE1521M
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
product: MODEL1310110023#
modifier: MODEL1310110023#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110023#
reversible: true
type: Reaction
name: RE1521
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17

metaR EX his L LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-histidine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_f8cde802_fa57_46cb_b4d9_3fe89986cfdb
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is: E7EPT3
is encoded by: hsa:501
name: ALDH7A1

metaR FACOAL80i
notes: GENE_ASSOCIATION: (2181.1) or (2181.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: NOTES:JLR Also 6.2.1.3
reactant: MODEL1310110023#
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
modifier: MODEL1310110023#
name: fatty-acid--CoA ligase (octanoate)
fast: false
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110023#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110023#_d573c5f7_9ce0_47b5_a31c_3812411f20c6
is encoded by: hsa:27034
constant: false
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
name: ACAD8
initial concentration: NaN
is: Q6ZWP6
initial amount: NaN

metaM 4abutn c
notes: FORMULA: C4H10NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
name: 4-Aminobutanal
is: HMDB01080
is: SBO:0000247
is: C00555
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:58264
constant: false
type: Species

metaR HACD1m
is described by: ECO:0000134
reactant: MODEL1310110023#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110023#
type: Reaction
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/4.2.1.17

metaM ocdececrn m
has only substance units: false
boundary condition: false
notes: FORMULA: C25H47NO4 CHARGE: 0
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB06351
name: 11-octadecenoyl carnitine

metaM HC00695 m
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
is: CHEBI:17432
type: Species
name: S-Succinyldihydrolipoamide
constant: false
is: SBO:0000247
boundary condition: false

metaM ade e
boundary condition: false
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
initial concentration: 1.0
name: adenine
is: CHEBI:16708
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: HMDB00034
is: SBO:0000247

metaM ksi deg39 l
has only substance units: false
type: Species
name: keratan sulfate I, degradation product 39
is: HMDB00143
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:12936
notes: FORMULA: C48H81N3O36 CHARGE: 0
boundary condition: false

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

metaR BILIRUBt2
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
kinetic law: MODEL1310110023#
reversible: true
reactant: MODEL1310110023#
type: Reaction
name: bilirubin transport via bicarbonate countertransport
modifier: MODEL1310110023#
product: MODEL1310110023#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110023#_be3b3f90_3897_452e_bcec_7fff82cf3d02
type: Species
name: _MBOAT5_1_c
is encoded by: hsa:MBOAT5
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false

metaM pro L c
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:17203
name: L-proline
has only substance units: false
is: HMDB00162
type: Species

metaM ocdcea r
initial amount: NaN
is: SBO:0000247
is: HMDB00207
boundary condition: false
notes: FORMULA: C18H33O2 CHARGE: -1
initial concentration: 1.0
is: CHEBI:0
has only substance units: false
constant: false
name: octadecenoate (n-C18:1)
is: C00712
type: Species

metaR r1629
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110023#
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000185
type: Reaction

metaR EX fmn LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for FMN
type: Reaction

metaR EX tststerone LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Testosterone exchange
type: Reaction

metaM hpdcacrn c
name: heptadecanoyl carnitine
boundary condition: false
notes: FORMULA: C24H47NO4 CHARGE: 0 INCHI: InChI=1/C24H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24(28)29-22(20-23(26)27)21-25(2,3)4/h22H,5-21H2,1-4H3
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB06210
initial concentration: 1.0
constant: false

metaM ps hs c
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:18303
constant: false
name: ps_hs[c]
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial amount: NaN

metaR D3AIBTm
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110023#
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
product: MODEL1310110023#
reactant: MODEL1310110023#
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110023#_c5906dd8_9b84_49f7_bfcd_77f136e188fd
constant: false
has only substance units: false
is: P34059
is encoded by: hsa:2588
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: GALNS
type: Species

metaR EX 4hpro LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hydroxy proline
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_89596ea6_4e3d_44c6_90f2_62885da4a286
initial concentration: NaN
name: _H45672_1_m
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:H45672
has only substance units: false
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_fac9101f_9a6a_4ae1_a8d2_4b1fe3340600
is: P78381
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:7355
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
name: SLC35A2

metaM dhap x
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB01473
is: C00111
has only substance units: false
is: CHEBI:57642
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/3411
name: Dihydroxyacetone phosphate

metaM 34hpp m
is: HMDB00707
initial concentration: 1.0
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
name: 3-(4-hydroxyphenyl)pyruvate
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:36242
constant: false
has only substance units: false
initial amount: NaN

metaR r1418
fast: false
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
is: SBO:0000176
type: Reaction
product: MODEL1310110023#
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
is described by: ECO:0000000

metaR EX prostgf2 LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin F2alpha exchange
type: Reaction

metaM btcoa m
initial amount: NaN
is: HMDB01088
boundary condition: false
initial concentration: 1.0
is: CHEBI:57371
name: Butanoyl-CoA
has only substance units: false
is: C00136
type: Species
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
is: SBO:0000247
constant: false

metaM pro L e
is: HMDB00162
boundary condition: false
name: L-proline
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:17203

metaM hpyr c
name: 3-hydroxypyruvate
notes: FORMULA: C3H3O4 CHARGE: -1 INCHI: InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00163 EHMN_ABBREVIATION: C00168
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB01352
type: Species
is: CHEBI:17180
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_4052a9fb_4874_4bec_8a7c_6121f93ff08e
type: Species
is: P30837
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:219
initial amount: NaN
name: ALDH1B1

metaR r0178
is described by: ECO:0000000
reactant: MODEL1310110023#
fast: false
kinetic law: MODEL1310110023#
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
is: SBO:0000176
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.5.1.21
modifier: MODEL1310110023#
reversible: true

metaR FAOXC163Gm
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)gm
type: Reaction

metaR G12MT2 U
kinetic law: MODEL1310110023#
is described by: ECO:0000000
fast: false
name: Glycolipid 1,2-alpha-D-mannosyltransferase (uterus)
is: SBO:0000176
reactant: MODEL1310110023#
type: Reaction
reversible: false
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110023#_61ac0e8a_64dc_4199_aeb6_e3c13635fa66
is: Q13733
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:480
initial amount: NaN
boundary condition: true
name: ATP1A4
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_2278e3b0_9c25_44a6_a8a8_cf5cd13fc995
name: DHCR24
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:1718
is: Q15392
has only substance units: false
constant: false
initial amount: NaN

metaR EX q10 LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinone
type: Reaction

metaM cs a deg5 l
is: CHEBI:15936
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C23H36O24S CHARGE: -2
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 5

metaR r0399
type: Reaction
reversible: true
kinetic law: MODEL1310110023#
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
product: MODEL1310110023#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.4.2
modifier: MODEL1310110023#
is: SBO:0000176
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110023#_96f1dce2_e0f3_4862_a65b_127f5bd1870d
is: E5KNH5
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: NDUFV1
is encoded by: hsa:4723
constant: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110023#_3aa0bbfd_43aa_40ca_8156_c1b40d95f80a
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: SBO:0000252
boundary condition: true
name: LALBA
is: P00709
is encoded by: hsa:3906
initial concentration: NaN

metaR r0179
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16
type: Reaction
modifier: MODEL1310110023#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.27
reactant: MODEL1310110023#
fast: false
kinetic law: MODEL1310110023#
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
is described by: ECO:0000000
is: SBO:0000176

metaR r1575
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110023#
is: SBO:0000185
product: MODEL1310110023#
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_ab2ccc05_ca32_4f07_9854_1af82488a319
is encoded by: hsa:4830
initial amount: NaN
boundary condition: true
name: NME1
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252

metaR NDP7ex
name: nucleoside-diphosphatase (UDP), extracellular
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12600208 NOTES:
product: MODEL1310110023#
modifier: MODEL1310110023#
is: SBO:0000176
reactant: MODEL1310110023#
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110023#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.6

metaR GGH 10FTHF6GLUe
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.4.19.9
fast: false
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
kinetic law: MODEL1310110023#
product: MODEL1310110023#
name: Gamma-glutamyl hydrolase (10FTHF6GLU), extracellular
type: Reaction
modifier: MODEL1310110023#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110023#_0a148a0c_b295_485a_9733_654e78a44cb0
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AI601100
initial concentration: NaN
has only substance units: false
name: _AI601100_1_m
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_03524c02_3714_4614_907f_47cb733b5abe
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AD000092
boundary condition: true
constant: false
type: Species
name: _AD000092_1_c

http://identifiers.org/biomodels.db/MODEL1310110023#_8e97b198_c93b_42ea_b80c_14ab0b527654
name: SLC2A3
initial concentration: NaN
is encoded by: hsa:6515
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: P11169
boundary condition: true
constant: false

metaM thym e
is: HMDB00262
boundary condition: false
has only substance units: false
notes: FORMULA: C5H6N2O2 CHARGE: 0 INCHI: InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17821
name: thymine
constant: false
initial amount: NaN
type: Species

metaM 5adtststerones c
initial amount: NaN
name: 5alpha-Dihydrotestosterone sulfate
is: HMDB06278
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
type: Species

metaR PCHOL HSter
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
name: phosphatidylcholine scramblase
fast: false
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000000

metaR r1574
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
is described by: ECO:0000000
product: MODEL1310110023#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110023#_98b66f6c_6170_42a8_8c47_f5f4feb5177a
is: SBO:0000252
has only substance units: false
is: Q9UBX3
name: SLC25A10
initial amount: NaN
is encoded by: hsa:1468
initial concentration: NaN
boundary condition: true
constant: false
type: Species

metaM CE5236 n
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB03952
is: CHEBI:28002
initial amount: NaN
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
type: Species
name: O2'-4a-cyclic-tetrahydrobiopterin

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

metaR URAt
is: SBO:0000185
fast: false
reactant: MODEL1310110023#
reversible: true
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
product: MODEL1310110023#
type: Reaction
modifier: MODEL1310110023#
name: uracil transport via facilated diffusion
is described by: ECO:0000269

metaR CYSGLYexR
type: Reaction
modifier: MODEL1310110023#
is described by: ECO:0000000
name: L-cysteine/glycine reversible exchanger
kinetic law: MODEL1310110023#
fast: false
is: SBO:0000185
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
reversible: true
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_dbfe9b75_39da_412f_bded_18be5dbd637f
name: SUCLG2:SUCLG1
constant: false
is encoded by: hsa:8801
has part: P53597
initial amount: NaN
has part: Q96I99
initial concentration: NaN
is encoded by: hsa:8802
is: SBO:0000297
has only substance units: false
type: Species
boundary condition: true

metaR RE3524R
type: Reaction
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
fast: false
name: RE3524
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
is: SBO:0000176
reversible: true
is described by: ECO:0000000

metaR LPS3
notes: GENE_ASSOCIATION: (11343.1) or (11343.2) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.23 Confidence Level: 4 AUTHORS: PMID:9495531 NOTES:NJ
modifier: MODEL1310110023#
fast: false
kinetic law: MODEL1310110023#
name: lipase
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.1.23
product: MODEL1310110023#
type: Reaction
reversible: false
reactant: MODEL1310110023#

metaR H2Otg
product: MODEL1310110023#
kinetic law: MODEL1310110023#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110023#
name: H2O transport, Golgi apparatus
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true

metaR r1573
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
reversible: true
product: MODEL1310110023#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000

metaR S6T5g
product: MODEL1310110023#
type: Reaction
reversible: false
reactant: MODEL1310110023#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110023#_24fd0142_d6fa_4550_a78f_5f8ea3d3e72f
is encoded by: hsa:23305
name: ACSL6
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
type: Species
is: B2RB13
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110023#_1388e905_cc2d_4728_aafb_e1efa7c53fff
initial amount: NaN
is: Q9H6R3
type: Species
name: ACSS3
initial concentration: NaN
constant: false
is encoded by: hsa:79611
is: SBO:0000252
has only substance units: false
boundary condition: true

metaM ura c
name: Uracil
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
is: CHEBI:17568
constant: false
boundary condition: false
is: C00106
is: HMDB00300
type: Species
initial amount: NaN
has only substance units: false

metaR FAOXC101C8x
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C8:0)x
type: Reaction

metaR SIAT4Bg
modifier: MODEL1310110023#
name: Beta-galactoside alpha-2,3-sialyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
reversible: false
is version of: http://identifiers.org/ec-code/2.4.99.4
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110023#
is: SBO:0000176
fast: false

metaM dolglcp U c
boundary condition: false
initial concentration: 1.0
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
has only substance units: false
type: Species
constant: false
is: CHEBI:15812
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_74658f06_c2a8_4829_b2a2_2e75e67146e1
has only substance units: false
is encoded by: hsa:1103
initial amount: NaN
name: CHAT
initial concentration: NaN
type: Species
boundary condition: true
is: P28329
constant: false
is: SBO:0000252

metaR CLPNDCOAtx
fast: false
product: MODEL1310110023#
type: Reaction
kinetic law: MODEL1310110023#
is described by: ECO:0000000
reactant: MODEL1310110023#
reversible: true
name: fatty acid intracellular transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

http://identifiers.org/biomodels.db/MODEL1310110023#_352111d1_5ca8_480e_9266_43577ec2aadd
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:6582
has only substance units: false
constant: false
name: SLC22A2

http://identifiers.org/biomodels.db/MODEL1310110023#_3f10caba_6afd_4c06_97bb_634c792ee7eb
initial concentration: NaN
constant: false
type: Species
is: Q16760
boundary condition: true
is: SBO:0000252
name: DGKD
initial amount: NaN
has only substance units: false
is encoded by: hsa:8527

metaR ITCOAL1m
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.4
product: MODEL1310110023#
type: Reaction
modifier: MODEL1310110023#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
reversible: true
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#

metaR UGT1A10r
product: MODEL1310110023#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.17
fast: false
is described by: ECO:0000134
is: SBO:0000176
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
reversible: true

metaM ksi pre9 g
constant: false
is: CHEBI:58053
is: C00130
notes: FORMULA: C121H196N8O93S2X CHARGE: -3
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 9
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB00175
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_5b83f6b4_76f3_4d4e_986c_d045499e6652
initial concentration: NaN
name: PDE6B
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5158
type: Species
initial amount: NaN
constant: false
is: B7Z9T9
has only substance units: false

metaM ppi x
type: Species
name: Diphosphate
initial concentration: 1.0
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: SBO:0000247
has only substance units: false
is: HMDB00250
constant: false
is: C00013
boundary condition: false
is: CHEBI:33019
initial amount: NaN

metaR LPS2
name: lipase
fast: false
notes: GENE_ASSOCIATION: (4023.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.3 Confidence Level: 4 AUTHORS: PMID:1969408 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
reactant: MODEL1310110023#
product: MODEL1310110023#
modifier: MODEL1310110023#
is described by: ECO:0000000
kinetic law: MODEL1310110023#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.1.1.34
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_bf59e63f_88d2_4544_9f4f_5857d3329152
is encoded by: hsa:5148
initial amount: NaN
name: PDE6G
is: SBO:0000252
is: P18545
constant: false
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false

metaM asp L e
is: HMDB00191
initial amount: NaN
has only substance units: false
type: Species
name: L-aspartate(1-)
is: CHEBI:29991
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247

metaR NAIt
fast: false
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110023#
reversible: true
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
is: SBO:0000185
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
name: Na+ / iodide cotransport

metaR r0791
modifier: MODEL1310110023#
product: MODEL1310110023#
reversible: true
kinetic law: MODEL1310110023#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
reactant: MODEL1310110023#
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_b395694d_a858_4e84_9ab9_020a7d64e4a1
name: _H77542_1_c
initial concentration: NaN
is encoded by: hsa:H77542
type: Species
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110023#_6360dbc6_abf9_4b0c_8bba_731c84cd8917
initial amount: NaN
constant: false
name: SLC4A10
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:57282
type: Species
is: B7Z1R0

metaR R group phosphotase 1
reversible: false
product: MODEL1310110023#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110023#
fast: false
is: SBO:0000176
name: R group phosphotase 1
reactant: MODEL1310110023#
type: Reaction

metaR THRCYSNaEx
reactant: MODEL1310110023#
reversible: false
modifier: MODEL1310110023#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
name: L-cysteine/L-threonine Na-dependent exchange (Thr-L in)
kinetic law: MODEL1310110023#
fast: false
product: MODEL1310110023#

metaR r1579
fast: false
product: MODEL1310110023#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110023#
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110023#
is: SBO:0000185

metaR FACOAL226
modifier: MODEL1310110023#
product: MODEL1310110023#
is: SBO:0000176
name: fatty-acid--CoA ligase
reversible: true
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ

metaR PACCOAL
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 6.2.1.30 Confidence Level: 2 AUTHORS: NOTES:JLR
fast: false
name: phenylacetate-CoA ligase
is: SBO:0000176
type: Reaction
reactant: MODEL1310110023#
product: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_6dde6c91_1d2c_4c4a_b153_c9cc04fd06f5
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:10606
is: P22234
name: PAICS
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_32ded2c2_9252_4c03_8590_20b5801664cc
boundary condition: true
name: VNN2
is: A8K7W0
type: Species
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:8875
initial amount: NaN
initial concentration: NaN

metaR LEULEULAPc
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: hydrolysis of Leucylleucine in the small intestine for cellular uptake
type: Reaction

metaM docohexcoa x
has only substance units: false
constant: false
initial amount: NaN
is: HMDB02288
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
name: 2,4,7,10,13,16-docosahexenoylcoa

metaR r2200
is described by: ECO:0000000
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
product: MODEL1310110023#
modifier: MODEL1310110023#
fast: false
type: Reaction
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110023#_09301af5_245d_4475_b9a8_be98bdb71e97
boundary condition: true
has only substance units: false
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:23057
is: Q9BZQ4
is: SBO:0000252
initial concentration: NaN
name: NMNAT2

metaM dmnoncrn x
type: Species
notes: FORMULA: C18H37NO4 CHARGE: 0
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: 4,8-dimethylnonanoyl carnitine
is: HMDB06202
constant: false
has only substance units: false

metaR r1578
product: MODEL1310110023#
reactant: MODEL1310110023#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_badaf154_dbb7_43b6_8fd4_f26724f671c4
initial concentration: NaN
boundary condition: true
name: GANC
is: Q8TET4
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:2595
is: SBO:0000252
has only substance units: false

metaM asp L c
name: L-aspartate(1-)
initial amount: NaN
is: HMDB00191
boundary condition: false
type: Species
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
initial concentration: 1.0
is: CHEBI:29991
is: SBO:0000247
constant: false
has only substance units: false

metaM lnlnca r
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
name: alpha-linolenate
constant: false
is: HMDB01388
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
is: CHEBI:32387

metaR VALPHELAT2tc
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Valine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaR GLUtr
is described by: ECO:0000000
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
name: intracellular transport
reversible: true
type: Reaction
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, needed to transport glu-L out of ER in conversion of leuktrC4-> leuktrD4 NJ
fast: false
is: SBO:0000185

metaR RE3003M
product: MODEL1310110023#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/5.3.3.8
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
is described by: ECO:0000000
modifier: MODEL1310110023#
name: RE3003
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110023#

metaM fad e
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB01248
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: C00016
is: CHEBI:16238
is: SBO:0000247
constant: false
boundary condition: false
name: Flavin adenine dinucleotide oxidized
type: Species

metaR r2358
name: Organic anion transporter 5 Utilized transport
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110023#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110023#
kinetic law: MODEL1310110023#
reversible: true

metaM ficytC m
name: Ferricytochrome c
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:15991
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
initial concentration: 1.0
has only substance units: false

metaM thym c
initial amount: NaN
initial concentration: 1.0
type: Species
is: C00178
is: SBO:0000247
is: HMDB00262
name: Thymine
notes: FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
is: CHEBI:17821
boundary condition: false
has only substance units: false
constant: false

metaR ACOAD10m
is described by: ECO:0000269
modifier: MODEL1310110023#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110023#
type: Reaction
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (36.1) or (34.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.3.99.3
name: acyl-CoA dehydrogenase (2-methylbutanoyl-CoA), mitochondrial
reversible: false

metaR ACETONEt2m
modifier: MODEL1310110023#
name: acetone mitochondrial transport via proton symport
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110023#
type: Reaction
fast: false

metaR R group phosphotase 3
product: MODEL1310110023#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
name: R group phosphotase 3
is: SBO:0000176
fast: false
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
type: Reaction
is described by: ECO:0000000

metaR DM dgpi prot hs r
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dgpi prot hs(r)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_9a637fb6_d6e4_4feb_9c68_fa953fbfcbf1
name: NDUFV1
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: E5KNH5
type: Species
boundary condition: true
constant: false
is encoded by: hsa:4723

metaR PPM
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/5.4.2.2
product: MODEL1310110023#
name: phosphopentomutase
reversible: true
notes: GENE_ASSOCIATION: (5236.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: NOTES:
modifier: MODEL1310110023#
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110023#_66948ad0_6a15_45a7_aeea_96461b315058
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1040
type: Species
name: CDS1
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
is: Q92903

metaR ASCBt
reactant: MODEL1310110023#
name: L-ascorbate transport via facilitated diffusion
product: MODEL1310110023#
kinetic law: MODEL1310110023#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
fast: false

metaM nm2masn g
is: SBO:0000247
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
initial amount: NaN
is: C05884
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C42H70N3O30X CHARGE: 0
has only substance units: false

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_aae65c9b_fc5d_41cb_9002_d9f2cc52efbe
name: OCRL
is encoded by: hsa:4952
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species

metaR r1576
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110023#
fast: false

metaR r2359
product: MODEL1310110023#
kinetic law: MODEL1310110023#
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
is: SBO:0000185
reactant: MODEL1310110023#
type: Reaction

metaR BMTer U
kinetic law: MODEL1310110023#
fast: false
product: MODEL1310110023#
is described by: ECO:0000000
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (9488.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8861954 NOTES:NCD
reversible: false
type: Reaction
name: B mannosyltransferase, endoplasmic reticulum
is: SBO:0000176
modifier: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_d66fd940_029b_4799_a795_6ce08ae86ad7
initial concentration: NaN
has only substance units: false
name: GALNS:GLB1:NEU1:CTSA
has part: P34059
initial amount: NaN
is encoded by: hsa:2588
boundary condition: true
has part: Q99519
has part: P16278
is encoded by: hsa:2720
is encoded by: hsa:4758
constant: false
has part: P10619
type: Species
is encoded by: hsa:5476
is: SBO:0000297

metaR R group phosphotase 2
name: R group phosphotase 2
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110023#
is: SBO:0000176
reversible: false

metaR GMPR
modifier: MODEL1310110023#
is: SBO:0000176
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (2766.1) or (51292.1) or (51292.3) or (51292.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.1.7 Confidence Level: 4 AUTHORS: PMID:12009299,PMID:8188226 NOTES:
reversible: false
fast: false
type: Reaction
name: GMP reductase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.7.1.7

metaM retinol c
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
is: HMDB00305
constant: false
is: CHEBI:50211
type: Species
name: retinol
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_3fd2e15d_b51e_4cb1_b54e_f257fd8979ad
has only substance units: false
is: SBO:0000252
constant: false
name: UCKL1
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is: Q53HM1
is encoded by: hsa:54963

metaM nh4 x
has only substance units: false
boundary condition: false
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: HMDB00051
is: CHEBI:28938
constant: false
type: Species
is: SBO:0000247
is: C01342
initial amount: NaN
name: Ammonium
initial concentration: 1.0

metaR SERPT
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.50
notes: GENE_ASSOCIATION: (10558.1 and 9517.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.3.1.50 Confidence Level: 4 AUTHORS: NOTES:NCD
type: Reaction
reactant: MODEL1310110023#
is: SBO:0000176
modifier: MODEL1310110023#
is described by: ECO:0000269
name: serine C-palmitoyltransferase
kinetic law: MODEL1310110023#
reversible: false
product: MODEL1310110023#

metaR C3STKR2r
product: MODEL1310110023#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER - NJ
fast: false
reactant: MODEL1310110023#
is described by: ECO:0000134
reversible: false
kinetic law: MODEL1310110023#
name: C-3 sterol keto reductase (zymosterol)
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/4.2.1.107

metaM tddedi2coa m
initial concentration: 1.0
is: HMDB12969
boundary condition: false
name: trans2,6dodecadienoylcoa
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
constant: false

metaM n2m2nmn l
initial concentration: 1.0
notes: FORMULA: C50H84N4O36 CHARGE: 0
type: Species
is: CHEBI:16680
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB00939
name: reducing GlcNAc removed form of n2m2nmasn (w/o peptide)
has only substance units: false
boundary condition: false

metaR FAOXC16080m
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
fast: false
reversible: false
is described by: ECO:0000269
product: MODEL1310110023#

metaR r2356
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reactant: MODEL1310110023#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110023#
reversible: true
fast: false
product: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_87f30779_6a72_4da2_b32a_c61b6b413b73
is: SBO:0000252
constant: false
is: P43353
has only substance units: false
name: ALDH3B1
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:221
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110023#_47f39750_8267_4858_835f_5a11e94a2968
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:84812
is: Q9BRC7
is: SBO:0000252
boundary condition: true
type: Species
name: PLCD4

metaR FAOXC101C8m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C8)m
type: Reaction

metaM fad c
boundary condition: false
name: Flavin adenine dinucleotide oxidized
is: CHEBI:16238
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB01248
is: C00016
initial concentration: 1.0
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
constant: false
initial amount: NaN

metaM dmnoncrn m
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
is: HMDB06202
notes: FORMULA: C18H37NO4 CHARGE: 0 INCHI: InChI=1/C18H35NO4/c1-14(2)8-7-9-15(3)10-11-18(22)23-16(12-17(20)21)13-19(4,5)6/h14-16H,7-13H2,1-6H3
name: 4,8 dimethylnonanoyl carnitine

metaM coa g
name: coenzyme A(4-)
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:57287
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
is: HMDB01423

http://identifiers.org/biomodels.db/MODEL1310110023#_eab9f8c5_04fb_4f67_b2ab_48622d1c6950
initial amount: NaN
is encoded by: hsa:6901
boundary condition: true
type: Species
is: SBO:0000252
is: Q16635
has only substance units: false
constant: false
initial concentration: NaN
name: TAZ

metaM ksii core2 deg6 l
is: HMDB00143
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
name: keratan sulfate II (core 2-linked), degradation product 6
notes: FORMULA: C44H72N4O33SX CHARGE: -1
initial amount: NaN
type: Species
is: CHEBI:12936

metaM CE4790 m
type: Species
is: SBO:0000247
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
has only substance units: false
constant: false
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:57923

http://identifiers.org/biomodels.db/MODEL1310110023#_71e29c0b_1df7_42b6_ab90_87188c7311ea
name: LDHB
has only substance units: false
is encoded by: hsa:3945
initial concentration: NaN
is: P07195
constant: false
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110023#_8293c955_e58b_43d3_b403_2fb87325a8f4
constant: false
has only substance units: false
name: FASN
is: P49327
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:2194

http://identifiers.org/biomodels.db/MODEL1310110023#_d3ddbba8_75d0_482a_bbc0_381d5c7c1f0d
has only substance units: false
boundary condition: true
is: Q9H490
is: SBO:0000252
name: PIGU
is encoded by: hsa:128869
constant: false
initial concentration: NaN
initial amount: NaN
type: Species

metaR FUCtly
name: L-fucose efflux from lysosome
fast: false
kinetic law: MODEL1310110023#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:
product: MODEL1310110023#
reactant: MODEL1310110023#
is: SBO:0000185
type: Reaction

metaR r2357
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: true
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
fast: false

metaM thbpt4acam n
type: Species
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
is: SBO:0000247
constant: false
is: HMDB02281
name: 4a-hydroxytetrahydrobiopterin
has only substance units: false
boundary condition: false
is: CHEBI:15374
initial concentration: 1.0
initial amount: NaN

metaR DURAD
reversible: true
fast: false
reactant: MODEL1310110023#
is described by: ECO:0000269
name: dihydrouracil dehydrogenase (NADP)
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.2
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
modifier: MODEL1310110023#
product: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_db70ff76_945f_4e9b_83c7_7076d83224ce
is: Q14916
is: SBO:0000252
name: SLC17A1
type: Species
has only substance units: false
is encoded by: hsa:6568
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_58acd66c_65ca_4196_a54b_f131547508f2
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
is: Q6PXP3
is encoded by: hsa:155184
initial concentration: NaN
name: SLC2A7
type: Species

metaR ACACt2
name: acetoacetate transport via proton symport
type: Reaction
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
fast: false
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110023#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110023#_1308edad_d5e5_4d32_b90d_d371d4a86ad6
is: P32019
has only substance units: false
is: SBO:0000252
name: INPP5B
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:3633

metaR SERASNNaEx
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
reversible: false
product: MODEL1310110023#
is described by: ECO:0000269
is: SBO:0000185
name: L-serine/L-asparagine Na-dependent exchange (Ser-L in)
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
modifier: MODEL1310110023#
fast: false

metaR r2201
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
product: MODEL1310110023#
type: Reaction
reversible: true
modifier: MODEL1310110023#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
fast: false

metaR r2354
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110023#
is: SBO:0000185
reversible: true
reactant: MODEL1310110023#
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110023#
name: Organic anion transporter 5 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110023#_1f932441_f850_47d2_bf32_532576bf1596
boundary condition: true
name: GBA
initial concentration: NaN
constant: false
is encoded by: hsa:2629
type: Species
initial amount: NaN
is: SBO:0000252
is: B7Z6S9
has only substance units: false

metaM trdox m
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
type: Species
constant: false
initial amount: NaN
name: Oxidized thioredoxin
is: CHEBI:18191
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false

metaR NRPPHRtu
reversible: true
fast: false
type: Reaction
product: MODEL1310110023#
reactant: MODEL1310110023#
name: Norepinephrine uniport
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
is: SBO:0000185
is described by: ECO:0000269

metaM ddsmsterol r
has only substance units: false
boundary condition: false
constant: false
name: 7-dehydrodesmosterol
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:27910
initial concentration: 1.0
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9-10,19,21,23-25,28H,6,8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01373
is: HMDB03896

metaR NACHEXA16ly
type: Reaction
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
modifier: MODEL1310110023#
product: MODEL1310110023#
name: beta-N-acetylhexosaminidase A, lysosomal
reversible: false
fast: false
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_73354d27_697f_49fe_b8e3_7204d978ab35
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
name: IDS
is: P22304
is encoded by: hsa:3423
constant: false
initial amount: NaN
initial concentration: NaN

metaR FAOXC142C122x
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)x
type: Reaction

metaM dgpi prot hs r
boundary condition: false
type: Species
is: HMDB01311
initial amount: NaN
initial concentration: 1.0
name: deacylated-glycophosphatidylinositol (GPI)-anchored protein
is: CHEBI:16004
notes: FORMULA: C39H76N4O37P4FULLRCO2FULLR2CO2X CHARGE: 0
has only substance units: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110023#_df3a8f19_3cb1_4085_9353_fd8a6a6a5dd6
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:115286
constant: false
boundary condition: true
type: Species
is: SBO:0000252
is: Q70HW3
name: SLC25A26
has only substance units: false

metaR r1467
product: MODEL1310110023#
reactant: MODEL1310110023#
fast: false
kinetic law: MODEL1310110023#
name: Postulated transport reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

metaR FUCACGALFUCGALACGLCGALGLUSIDEtg
kinetic law: MODEL1310110023#
product: MODEL1310110023#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
reversible: true
name: blood group intracellular transport
fast: false
reactant: MODEL1310110023#
type: Reaction
is described by: ECO:0000000

metaM aacoa m
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
initial amount: NaN
constant: false
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
name: acetoacetyl-CoA(4-)
is: SBO:0000247
is: CHEBI:57286
is: HMDB01484

metaR GLNALANaEx
product: MODEL1310110023#
reversible: false
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
name: L-alanine/L-glutamine Na-dependent exchange (Gln-L in)
modifier: MODEL1310110023#
is: SBO:0000185

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

metaR M16NTg
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
reversible: false
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (4247.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.143 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.143
name: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
fast: false
type: Reaction

metaM xol7ah2 c
has only substance units: false
initial concentration: 1.0
is: HMDB06893
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
is: CHEBI:28047
name: 5beta-cholestane-3alpha,7alpha-diol
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaR r2355
name: Organic anion transporter 5 Utilized transport
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110023#
is: SBO:0000185
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
product: MODEL1310110023#

metaR r2202
is described by: ECO:0000000
product: MODEL1310110023#
reactant: MODEL1310110023#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
kinetic law: MODEL1310110023#
reversible: true
modifier: MODEL1310110023#
is: SBO:0000185

metaR S6TASE1ly
reactant: MODEL1310110023#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
name: N-acetylglucosamine-6-sulfatase, lysosomal
product: MODEL1310110023#
modifier: MODEL1310110023#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.14
kinetic law: MODEL1310110023#
fast: false

metaM 34dhmald m
initial concentration: 1.0
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
is: C05577
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: 3,4-Dihydroxymandelaldehyde
boundary condition: false
is: HMDB06242
type: Species
is: http://identifiers.org/pubchem.compound/7903
constant: false

metaR RE2814M
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110023#
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
reactant: MODEL1310110023#
name: RE2814
is: SBO:0000176

metaR M13N2Tg
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.101
modifier: MODEL1310110023#
fast: false
is described by: ECO:0000000
product: MODEL1310110023#
is: SBO:0000176
reversible: false
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
name: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
notes: GENE_ASSOCIATION: (4245.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.101 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110023#_845c6614_e990_48e7_9e53_5fb22060548b
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
name: SLC6A10P
is encoded by: hsa:386757
type: Species

metaM ura e
initial amount: NaN
boundary condition: false
is: HMDB00300
initial concentration: 1.0
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
constant: false
name: uracil
is: SBO:0000247
type: Species
is: CHEBI:17568
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_81230945_a80a_4047_999c_69a26eaa78a6
name: ACP6
is: SBO:0000252
boundary condition: true
is: Q9NPH0
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
has only substance units: false
is encoded by: hsa:51205

metaR DCMPDA
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
name: dCMP deaminase
product: MODEL1310110023#
reversible: true
fast: false
is: SBO:0000176
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/3.5.4.12
modifier: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_80456055_b3de_4c0d_b6d5_5693f24b5624
name: ITPKA
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3706
initial amount: NaN
is: P23677
constant: false
boundary condition: true
type: Species

metaM pail345p hs c
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981
is: CHEBI:57836
initial amount: NaN
type: Species
boundary condition: false
constant: false
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
is: SBO:0000247

metaR r1466
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
name: EC:2.3.1.86
reactant: MODEL1310110023#
is described by: ECO:0000000
kinetic law: MODEL1310110023#
product: MODEL1310110023#
type: Reaction
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110023#_71d01252_a467_4db7_a297_2a4560dab682
initial amount: NaN
has only substance units: false
boundary condition: true
is: P04844
is encoded by: hsa:6185
constant: false
initial concentration: NaN
name: RPN2
type: Species
is: SBO:0000252

metaM adrncoa x
is: http://identifiers.org/pubchem.compound/47205480
boundary condition: false
name: adrenyl coenzyme A
has only substance units: false
is: SBO:0000247
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
type: Species
initial amount: NaN
constant: false
is: C16170
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110023#_b6762972_900d_4a72_abcc_0471c5b9b45c
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
name: KDSR
initial concentration: NaN
constant: false
is: Q06136
is encoded by: hsa:2531

metaR r2352
name: Organic anion transporter 5 Utilized transport
fast: false
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110023#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
product: MODEL1310110023#
reversible: true

metaR r1571
product: MODEL1310110023#
reactant: MODEL1310110023#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110023#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_c2bbb82a_5ccf_4aeb_a805_1088fe1793bc
is encoded by: hsa:121278
type: Species
initial concentration: NaN
constant: false
name: TPH2
has only substance units: false
is: Q8IWU9
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR NACHEXA19ly
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is: SBO:0000176
modifier: MODEL1310110023#
fast: false
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase A, lysosomal
reactant: MODEL1310110023#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110023#
type: Reaction

metaM s7p c
type: Species
initial concentration: 1.0
is: C05382
is: HMDB01068
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382
name: Sedoheptulose 7-phosphate
is: SBO:0000247
is: CHEBI:57483
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_f2f7b3e7_2754_4963_b1e8_d42804b7d21c
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:50614
initial concentration: NaN
is: Q9HCQ5
name: GALNT9
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_c5fbe36d_31c9_4727_aa6c_313fddd7edbd
constant: false
name: CDO1
initial amount: NaN
has only substance units: false
is encoded by: hsa:1036
initial concentration: NaN
is: Q16878
boundary condition: true
is: SBO:0000252
type: Species

metaR GLYCLTtp
product: MODEL1310110023#
is described by: ECO:0000000
reactant: MODEL1310110023#
reversible: false
name: glycolate transport into peroxisome
fast: false
type: Reaction
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110023#_41143298_82bd_400b_a15e_dd7ea64153a8
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:114805
is: SBO:0000252
type: Species
is: Q8IUC8
has only substance units: false
name: GALNT13

metaM coa c
type: Species
is: CHEBI:3312
constant: false
is: HMDB01423
notes: FORMULA: C21H32N7O16P3S CHARGE: -4
initial amount: NaN
initial concentration: 1.0
name: Coenzyme A
has only substance units: false
is: C00010
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110023#_1e15aa3d_1650_4362_9a8f_972f9b883700
name: LIPA
is: P38571
is encoded by: hsa:3988
has only substance units: false
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaM ser L m
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:17115
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
initial amount: NaN
name: L-serine
initial concentration: 1.0
is: HMDB00187
type: Species

metaM ksi deg29 l
boundary condition: false
is: HMDB00143
is: CHEBI:12936
initial amount: NaN
has only substance units: false
notes: FORMULA: C96H157N6O80S3 CHARGE: -3
is: SBO:0000247
type: Species
constant: false
name: keratan sulfate I, degradation product 29
initial concentration: 1.0

metaM ksii core4 pre8 g
is: HMDB00175
name: keratan sulfate II biosynthesis, precursor 8
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
is: C00130
type: Species
is: CHEBI:58053
has only substance units: false
initial amount: NaN
notes: FORMULA: C83H134N7O61SX CHARGE: -2

metaR SMPD4
product: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ
fast: false
reactant: MODEL1310110023#
name: sphingomyelinase
kinetic law: MODEL1310110023#
reversible: false
type: Reaction

metaR r2353
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
type: Reaction
name: Organic anion transporter 5 Utilized transport
fast: false
reversible: true
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
is: SBO:0000185

metaR r1570
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110023#
reversible: true
reactant: MODEL1310110023#
is described by: ECO:0000000
fast: false
is: SBO:0000185
kinetic law: MODEL1310110023#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_09b4424a_cb0d_437a_8101_ff1f0b2c96e7
is: Q7Z7M8
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:374907
name: B3GNT8
is: SBO:0000252
type: Species

metaM 5aop m
name: 5-Amino-4-oxopentanoate
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17549
is: HMDB01149
has only substance units: false
type: Species
initial amount: NaN
is: C00430
boundary condition: false
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430

metaR FAOXC102C103m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)m
type: Reaction

metaM clpndcoa c
constant: false
is: SBO:0000247
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
name: clupanodonyl CoA
is: HMDB06267
type: Species
is: http://identifiers.org/pubchem.compound/47205476
initial amount: NaN
is: C16166
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaM zym int2 r
initial amount: NaN
has only substance units: false
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-20,23-24H,6,8-17H2,1-5H3/t19-,20+,23-,24+,26+,27-/m1/s1
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
name: zymosterol intermediate 2
is: SBO:0000247
is: CHEBI:52386

metaR RE2814R
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110023#
product: MODEL1310110023#
kinetic law: MODEL1310110023#
fast: false
is: SBO:0000176
name: RE2814

metaR APOC LYS BTNPm
name: proteolysis of apoC-Lys-btn, mitochondrial
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110023#
is: SBO:0000176
kinetic law: MODEL1310110023#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_3c71e9cd_6b0f_46f5_a7b9_361eedcef096
constant: false
name: CPT1B
is encoded by: hsa:1375
is: E9PCP2
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaM hs deg8 l
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C69H100N4O81S8 CHARGE: -10
has only substance units: false
name: heparan sulfate, degradation product 8
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16126
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_7c814f4c_ae1b_43c0_ae2c_68e6f858372f
type: Species
is: B2ZGL7
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:11343
boundary condition: true
name: MGLL
initial amount: NaN
has only substance units: false

metaR FAOXC163GC142m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)gm
type: Reaction

metaM ksii core2 pre9 g
is: CHEBI:28067
boundary condition: false
initial amount: NaN
type: Species
name: keratan sulfate II biosynthesis, precursor 9
initial concentration: 1.0
notes: FORMULA: C75H120N6O59S2X CHARGE: -3
has only substance units: false
is: SBO:0000247
constant: false

metaR r1464
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
is: SBO:0000185
name: Active transport
is described by: ECO:0000000
product: MODEL1310110023#
reversible: true
fast: false

metaR r1609
product: MODEL1310110023#
reactant: MODEL1310110023#
type: Reaction
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110023#

metaR FOLt2le
is: SBO:0000185
fast: false
product: MODEL1310110023#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
name: folate transport via anion exchange
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
type: Reaction

metaM pail3p hs n
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
initial concentration: 1.0
is: CHEBI:58088
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C04549
constant: false

metaM lnlnca l
initial amount: NaN
is: CHEBI:32387
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
is: SBO:0000247
is: HMDB01388
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: alpha-linolenate
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_7ba6b3bd_86bd_4b8e_a926_28327cd39970
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6520
name: SLC3A2
is: SBO:0000252
constant: false
type: Species
is: P08195
boundary condition: true
initial amount: NaN

metaM 5thf e
is: HMDB06487
has only substance units: false
notes: FORMULA: C39H45N11O18 CHARGE: -6
name: pentaglutamyl folate (THF)
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species

metaR EX Lcystin LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Cystine exchange
type: Reaction

metaR CYSSERNaEx
type: Reaction
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110023#
is described by: ECO:0000269
reactant: MODEL1310110023#
name: L-serine/L-cysteine Na-dependent exchange (Cys-L in)
product: MODEL1310110023#
fast: false
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

http://identifiers.org/biomodels.db/MODEL1310110023#_62f973fb_589d_408e_a8ef_0009585590e1
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
name: _2544_1_c
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2544
constant: false

metaM ttetddcoa m
constant: false
name: trans5,8tetradecadienoylcoa
has only substance units: false
is: HMDB02288
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species

metaR LALDO2x
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:AMF
fast: false
type: Reaction
modifier: MODEL1310110023#
reversible: false
is described by: ECO:0000269
name: D-Lactaldehyde:NAD+ 1-oxidoreductase
is: SBO:0000176
reactant: MODEL1310110023#
product: MODEL1310110023#
kinetic law: MODEL1310110023#

metaR r2361
fast: false
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
reversible: true
reactant: MODEL1310110023#
is described by: ECO:0000000
kinetic law: MODEL1310110023#
type: Reaction
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110023#_91cae248_541f_4ebb_bdf6_ffc3cc3d89a7
initial amount: NaN
is: SBO:0000252
name: CA12
initial concentration: NaN
has only substance units: false
constant: false
is: O43570
boundary condition: true
is encoded by: hsa:771
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_11afe9ed_4681_4a99_b503_862682340d2d
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:125965
has only substance units: false
is: SBO:0000252
is: Q6YFQ2
type: Species
constant: false
name: COX6B2

http://identifiers.org/biomodels.db/MODEL1310110023#_8492ef24_ac88_49ad_8e16_546e8e85dc37
is: B8ZZR8
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
constant: false
name: GGCT
initial amount: NaN
is encoded by: hsa:79017
boundary condition: true

metaR EX n2m2nmasn LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R exchange
type: Reaction

metaR ACACT1x
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
product: MODEL1310110023#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.3.1.9
fast: false
reactant: MODEL1310110023#
reversible: false
is: SBO:0000176
type: Reaction
name: acetyl-CoA C-acetyltransferase, mitochondrial
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:11108725 NOTES:NCD NJ - added peroxisomal version

metaR HAS2
kinetic law: MODEL1310110023#
product: MODEL1310110023#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.212
reversible: false
modifier: MODEL1310110023#
is: SBO:0000185
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
is described by: ECO:0000269
reactant: MODEL1310110023#
name: hyaluronan synthase

metaR DPCOAK
type: Reaction
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
fast: false
name: dephospho-CoA kinase
is version of: http://identifiers.org/ec-code/2.7.7.3
is described by: ECO:0000269
is: SBO:0000176
reversible: false
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR MI14P4P
name: inositol-1,4-bisphosphate 4-phosphatase
reactant: MODEL1310110023#
type: Reaction
product: MODEL1310110023#
fast: false
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
kinetic law: MODEL1310110023#
is: SBO:0000176

metaR r1619
type: Reaction
reactant: MODEL1310110023#
is described by: ECO:0000000
modifier: MODEL1310110023#
is: SBO:0000185
product: MODEL1310110023#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110023#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM ksi pre23 g
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:28067
name: keratan sulfate I biosynthesis, precursor 23
notes: FORMULA: C185H296N13O153S7X CHARGE: -8
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaR DSREDUCr
reactant: MODEL1310110023#
modifier: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book.
is described by: ECO:0000134
is: SBO:0000176
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reversible: false
name: Desmosterol reductase
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.72

metaR r2360
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
product: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110023#
type: Reaction
name: Organic anion transporter 5 Utilized transport
fast: false
kinetic law: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_8446160b_0acf_44d0_84e2_e9c1a6d2ba50
is: O00764
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
name: PDXK
is encoded by: hsa:8566
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_f09a47e0_4e36_4de1_88d0_48248ce53527
is: SBO:0000252
is encoded by: hsa:47
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
constant: false
name: ACLY
has only substance units: false
is: P53396

metaR S6T10g
modifier: MODEL1310110023#
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110023#
fast: false
reversible: false
kinetic law: MODEL1310110023#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_d7a3e0a3_32f7_4f81_bebd_96c462082e33
name: MVD
has only substance units: false
is: SBO:0000252
is: P53602
is encoded by: hsa:4597
type: Species
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_70498832_f544_4d3e_821c_2a731e5096e3
initial concentration: NaN
has only substance units: false
is: O95622
constant: false
name: ADCY5
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:111

metaM docohepcoa m
type: Species
notes: FORMULA: C43H60N7O17P3S CHARGE: -4
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
name: 2,4,7,10,13,16,19-docosaheptenoylcoa
initial concentration: 1.0
is: HMDB02288
constant: false

metaR r2420
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000185
product: MODEL1310110023#
fast: false
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#

metaR 3SPYRSPm
name: 3-sulfinopyruvate hydrolase (spotaneous reaction), mitochondrial
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM
reactant: MODEL1310110023#
is: SBO:0000176
product: MODEL1310110023#
fast: false
kinetic law: MODEL1310110023#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_c7548a0f_7b46_4b45_be71_b6ba3baf84cf
initial concentration: NaN
is: O95299
boundary condition: true
initial amount: NaN
name: NDUFA10
is: SBO:0000252
constant: false
type: Species
has only substance units: false
is encoded by: hsa:4705

metaM thr L e
is: HMDB00167
is: CHEBI:16857
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
name: L-threonine
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species

metaR r1617
reversible: true
fast: false
kinetic law: MODEL1310110023#
type: Reaction
reactant: MODEL1310110023#
is described by: ECO:0000000
modifier: MODEL1310110023#
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110023#

metaM nadh m
is: SBO:0000247
name: Nicotinamide adenine dinucleotide - reduced
constant: false
initial amount: NaN
is: CHEBI:57945
has only substance units: false
is: C00004
boundary condition: false
is: http://identifiers.org/pubchem.compound/3306
type: Species
initial concentration: 1.0
is: HMDB01487

metaM 4hbzcoa m
boundary condition: false
has only substance units: false
is: HMDB06467
initial concentration: 1.0
initial amount: NaN
name: 4-hydroxybenoyl-CoA
type: Species
is: SBO:0000247
notes: FORMULA: C28H36N7O18P3S CHARGE: -4 INCHI: InChI=1/C28H40N7O18P3S/c1-28(2,22(39)25(40)31-8-7-18(37)30-9-10-57-27(41)15-3-5-16(36)6-4-15)12-50-56(47,48)53-55(45,46)49-11-17-21(52-54(42,43)44)20(38)26(51-17)35-14-34-19-23(29)32-13-33-24(19)35/h3-6,13-14,17,20-22,26,36,38-39H,7-12H2,1-2H3,(H,30,37)(H,31,40)(H,45,46)(H,47,48)(H2,29,32,33)(H2,42,43,44)/t17-,20?,21-,22+,26-/m1/s1
constant: false

metaR PETOHMr hs
is version of: http://identifiers.org/ec-code/2.1.1.17
product: MODEL1310110023#
is: SBO:0000176
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-Prot] NJ
modifier: MODEL1310110023#
fast: false
is described by: ECO:0000254
reactant: MODEL1310110023#
reversible: false
type: Reaction
name: phosphatidylethanolamine N-methyltransferase

metaR EX thym LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_755091df_81d5_40a4_a740_1861045aacf6
is: Q9C0J1
initial concentration: NaN
is: SBO:0000252
name: B3GNT4
is encoded by: hsa:79369
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_c6565303_68a2_485a_95c7_f10a76661c2f
type: Species
initial amount: NaN
constant: false
name: _BE042354_1_m
is encoded by: hsa:BE042354
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR r0340
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
product: MODEL1310110023#
reversible: false
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.38
is: SBO:0000176
is described by: ECO:0000000

metaR S4TASE2ly
fast: false
kinetic law: MODEL1310110023#
is described by: ECO:0000000
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
reversible: true
name: N-acetylgalactosamine-4-sulfatase, lysosomal
is: SBO:0000176
type: Reaction
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.1.6.12
modifier: MODEL1310110023#

metaM coa r
name: Coenzyme A
type: Species
is: C00010
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:57287
is: HMDB01423

metaR r1618
reactant: MODEL1310110023#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110023#
kinetic law: MODEL1310110023#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

metaM i c
boundary condition: false
name: iodide
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:16382
is: SBO:0000247
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
type: Species
is: HMDB12238

metaR r0917
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
is: SBO:0000185
reactant: MODEL1310110023#
type: Reaction
reversible: true
product: MODEL1310110023#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110023#
is described by: ECO:0000000

metaM thr L c
boundary condition: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
type: Species
name: L-threonine
is: CHEBI:16857
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB00167

metaR TAURtcx
reactant: MODEL1310110023#
is: SBO:0000185
modifier: MODEL1310110023#
reversible: true
notes: GENE_ASSOCIATION: (6533.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:8010975 NOTES:SAB
product: MODEL1310110023#
fast: false
name: taurine transport (sodium symport) (cytosol to peroxisome)
type: Reaction
kinetic law: MODEL1310110023#
is described by: ECO:0000212

http://identifiers.org/biomodels.db/MODEL1310110023#_e24aab58_aa81_4a3f_a63f_6387ba5edcdb
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:11227
initial amount: NaN
name: GALNT5
is: A5PKZ1
type: Species
has only substance units: false

metaM ksii core2 pre6 g
name: keratan sulfate II biosynthesis, precursor 6
initial amount: NaN
constant: false
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28067
notes: FORMULA: C61H98N5O46SX CHARGE: -2

metaR r0644
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reversible: true
is described by: ECO:0000000
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
reactant: MODEL1310110023#
type: Reaction

metaR ACACT10m
reversible: true
type: Reaction
name: acetyl-CoA C-acetyltransferase, mitochondrial
is version of: http://identifiers.org/ec-code/2.3.1.9
is described by: ECO:0000134
kinetic law: MODEL1310110023#
is: SBO:0000176
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
product: MODEL1310110023#
fast: false
modifier: MODEL1310110023#

metaR EX leuktrE4 LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene E4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_ab2f9e66_f5e9_4d58_a8cf_8f0801316d21
name: PANK1
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:53354
boundary condition: true
initial concentration: NaN
has only substance units: false

metaM ppi n
type: Species
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
has only substance units: false
is: HMDB00250
is: SBO:0000247
initial amount: NaN
is: CHEBI:33019
constant: false
boundary condition: false
initial concentration: 1.0
name: diphosphate(3-)

metaM ser L e
boundary condition: false
is: HMDB00187
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
type: Species
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:17115
name: L-serine
is: SBO:0000247

metaM Ssq23epx r
type: Species
is: CHEBI:15441
has only substance units: false
constant: false
name: (S)-2,3-epoxysqualene
boundary condition: false
is: SBO:0000247
is: HMDB01188
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-24(2)14-11-17-27(5)20-12-18-25(3)15-9-10-16-26(4)19-13-21-28(6)22-23-29-30(7,8)31-29/h14-16,20-21,29H,9-13,17-19,22-23H2,1-8H3/b25-15+,26-16+,27-20+,28-21+/t29-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00645 EHMN_ABBREVIATION: C01054
initial concentration: 1.0
initial amount: NaN

metaR r1720
reactant: MODEL1310110023#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110023#
fast: false
reversible: false
product: MODEL1310110023#
is: SBO:0000185
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110023#_2e5872d9_1892_4de6_8c87_dda1caa63bc7
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:5158
constant: false
boundary condition: true
has part: Q13956
has part: P16499
name: PDE6A:PDE6H:PDE6B
is encoded by: hsa:5145
is encoded by: hsa:5149
type: Species
has part: B7Z9T9
is: SBO:0000297

metaR r1615
type: Reaction
reactant: MODEL1310110023#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110023#
product: MODEL1310110023#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true

metaM lnlnca c
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
is: HMDB01388
name: alpha-linolenate
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:32387
initial concentration: 1.0

metaM nadh r
is: SBO:0000247
has only substance units: false
is: CHEBI:57945
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
boundary condition: false
name: NADH(2-)
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
is: HMDB01487

http://identifiers.org/biomodels.db/MODEL1310110023#_56df197b_a7eb_4635_9714_21fae754084a
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: MSMO1
is encoded by: hsa:6307
type: Species
has only substance units: false
boundary condition: true
is: A8MYF6

metaM CE5236 c
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
initial concentration: 1.0
name: O2'-4a-cyclic-tetrahydrobiopterin
initial amount: NaN
is: HMDB03952
is: CHEBI:28002
constant: false
is: SBO:0000247

metaM dcamp c
initial amount: NaN
initial concentration: 1.0
is: C03794
is: CHEBI:57567
boundary condition: false
is: HMDB00536
is: SBO:0000247
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
name: N6-(1,2-Dicarboxyethyl)-AMP
constant: false
type: Species
has only substance units: false

metaM ppi m
constant: false
type: Species
is: C00013
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB00250
name: Diphosphate
initial amount: NaN
is: SBO:0000247
is: CHEBI:33019

metaR r1616
modifier: MODEL1310110023#
fast: false
reversible: true
kinetic law: MODEL1310110023#
product: MODEL1310110023#
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110023#

metaR THYOXt
notes: GENE_ASSOCIATION: (53919.1) or (6579.1) or (28231.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
reactant: MODEL1310110023#
type: Reaction
reversible: true
is described by: ECO:0000269
name: T4 transport via bicarbonate countertransport
kinetic law: MODEL1310110023#
fast: false
is: SBO:0000185
product: MODEL1310110023#
modifier: MODEL1310110023#

metaM i e
type: Species
initial amount: NaN
is: CHEBI:16382
initial concentration: 1.0
boundary condition: false
is: HMDB12238
constant: false
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
name: iodide
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110023#_b26afcab_5a7f_4bee_a32a_b348a1963102
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
name: NOS3
boundary condition: true
constant: false
is: A0S0A7
is encoded by: hsa:4846
is: SBO:0000252

metaR RE1520M
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE1520
modifier: MODEL1310110023#
type: Reaction
fast: false
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110023#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110023#_90b6bd29_36c6_4039_a0f5_ea576282c3c1
type: Species
is: SBO:0000252
has only substance units: false
name: HADHA
boundary condition: true
is encoded by: hsa:3030
initial concentration: NaN
initial amount: NaN
is: E9KL44
constant: false

metaM ump c
name: UMP
is: HMDB00288
is: C00105
constant: false
initial amount: NaN
is: CHEBI:57865
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species

metaR r0642
reactant: MODEL1310110023#
type: Reaction
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
fast: false
kinetic law: MODEL1310110023#
is: SBO:0000176
product: MODEL1310110023#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110023#_621a55e5_bfb0_4e13_ab58_ae5cc0a2b2ae
type: Species
boundary condition: true
name: _AW299740_1_m
constant: false
initial amount: NaN
is encoded by: hsa:AW299740
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM dectricoa m
notes: FORMULA: C31H44N7O17P3S CHARGE: -4
constant: false
name: 2,4,7-decatrienoylcoa
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species

metaR EX dopasf LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine 3-O-sulfate exchange
type: Reaction

metaM coa m
is: HMDB01423
has only substance units: false
is: SBO:0000247
name: Coenzyme A
initial amount: NaN
type: Species
is: C00010
is: CHEBI:57287
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010

metaM 3hpcoa m
is: CHEBI:58528
boundary condition: false
is: HMDB06807
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
is: SBO:0000247
initial concentration: 1.0
name: 3-hydroxypropanoyl-CoA(4-)
constant: false
initial amount: NaN
type: Species
has only substance units: false

metaM cspg e e
is: HMDB00300
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
is: SBO:0000247
constant: false
is: CHEBI:17568
is: C00106
initial amount: NaN

metaR C3STDH1r
reactant: MODEL1310110023#
type: Reaction
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER version NJ
fast: false
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.1.1.170
name: C-3 sterol dehydrogenase (4-methylzymosterol)
is described by: ECO:0000134
product: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_6fa7bd73_f9aa_4669_9438_5661a6d44a91
is encoded by: hsa:594
boundary condition: true
has part: Q9BQL0
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000297
initial amount: NaN
name: DBT:DLD:BCKDHA:BCKDHB

metaR r0345
reactant: MODEL1310110023#
reversible: true
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
fast: false
type: Reaction
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.3.99.3
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
is version of: http://identifiers.org/ec-code/1.3.99.13
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.3.3.6
modifier: MODEL1310110023#
is: SBO:0000176
is described by: ECO:0000000

metaR r1613
is: SBO:0000185
kinetic law: MODEL1310110023#
reversible: true
type: Reaction
reactant: MODEL1310110023#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110023#
modifier: MODEL1310110023#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_725a587a_a60a_4692_8a1f_feaab6090370
is: SBO:0000252
is encoded by: hsa:55343
boundary condition: true
initial amount: NaN
name: SLC35C1
type: Species
constant: false
is: B3KQH0
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_da820b29_dd39_48ff_b367_b04425331eed
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
name: NOS1
initial concentration: NaN
is: B4DG68
is encoded by: hsa:4842
is: SBO:0000252
type: Species

metaM m4mpdol U c
initial amount: NaN
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:37633
has only substance units: false
boundary condition: false
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_9832142b_fb4f_4e9f_b9c2_d6c89df287c0
is: P51688
initial concentration: NaN
name: SGSH
initial amount: NaN
constant: false
is encoded by: hsa:6448
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_382c4d7f_ed32_4432_b703_bbbe33151b27
boundary condition: true
is encoded by: hsa:3163
type: Species
is: P30519
name: HMOX2
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaM anth c
boundary condition: false
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
is: CHEBI:16567
name: anthranilate
is: HMDB01123
is: SBO:0000247

metaM lnlnca e
initial amount: NaN
constant: false
is: CHEBI:32387
initial concentration: 1.0
is: HMDB01388
has only substance units: false
boundary condition: false
is: SBO:0000247
name: alpha-linolenate
type: Species
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-

metaM coa n
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
initial amount: NaN
type: Species
is: HMDB01423
constant: false
is: CHEBI:57287
name: coenzyme A(4-)
boundary condition: false
has only substance units: false

metaR r0641
fast: false
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
product: MODEL1310110023#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
modifier: MODEL1310110023#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.2.4
reversible: true

metaR ADKd
name: adenylate kinase (d form)
product: MODEL1310110023#
type: Reaction
modifier: MODEL1310110023#
is: SBO:0000176
reactant: MODEL1310110023#
is described by: ECO:0000269
kinetic law: MODEL1310110023#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.3
reversible: true
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)

metaR r1614
fast: false
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110023#

metaM hs deg16 l
is: HMDB02704
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:21338
constant: false
name: heparan sulfate, degradation product 16
type: Species
notes: FORMULA: C49H72N2O54S4 CHARGE: -6

metaR UMPK4
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
product: MODEL1310110023#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
name: UMP kinase (GTP)
reactant: MODEL1310110023#
is described by: ECO:0000269

metaR r1611
fast: false
product: MODEL1310110023#
reversible: true
reactant: MODEL1310110023#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_0672e30c_0997_42ec_9111_1eaf619daba3
is encoded by: hsa:6487
type: Species
name: ST3GAL3
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN

metaM ump e
initial concentration: 1.0
is: HMDB00288
type: Species
is: SBO:0000247
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: CHEBI:57865
constant: false
initial amount: NaN
boundary condition: false
name: UMP(2-)
has only substance units: false

metaM coa x
type: Species
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: C00010
name: Coenzyme A
is: HMDB01423
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57287
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_e49dfb38_deef_4fda_9a7b_ba4f71634d3c
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:217
is: P05091
boundary condition: true
has only substance units: false
name: ALDH2
type: Species
initial amount: NaN

metaR r0913
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
product: MODEL1310110023#
type: Reaction
fast: false
reversible: true

metaM HC02210 c
name: prostaglandin-d3
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:34939
constant: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
initial amount: NaN
boundary condition: false
has only substance units: false

metaR EX ahdt LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 7,8-dihydroneopterin 3-triphosphate(4-)
type: Reaction

metaM ppi r
boundary condition: false
constant: false
has only substance units: false
name: Diphosphate
is: C00013
is: SBO:0000247
initial concentration: 1.0
is: HMDB00250
type: Species
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial amount: NaN
is: CHEBI:33019

metaR r0603
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
type: Reaction
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
product: MODEL1310110023#
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
is: SBO:0000176
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.3.1.12

metaM HC00361 c
is: CHEBI:58335
name: sedoheptulose 1,7-bisphosphate(4-)
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species

metaR r1612
reactant: MODEL1310110023#
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
product: MODEL1310110023#

metaR SPH1Pte
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
reactant: MODEL1310110023#
name: sph1p transport
product: MODEL1310110023#
type: Reaction
kinetic law: MODEL1310110023#
is described by: ECO:0000000

metaM docohexcoa m
boundary condition: false
is: HMDB02288
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
type: Species
initial amount: NaN
is: SBO:0000247
name: 2,4,7,10,13,16-docosahexenoylcoa
constant: false

metaR UMPK5
is described by: ECO:0000269
kinetic law: MODEL1310110023#
product: MODEL1310110023#
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
reactant: MODEL1310110023#
name: UMP kinase (dATP)
fast: false
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_cfa88c33_7527_4595_bdc3_c9c2a1329625
type: Species
is: Q13615
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:8897
initial concentration: NaN
is: SBO:0000252
name: MTMR3
initial amount: NaN

metaM glcur c
has only substance units: false
initial concentration: 1.0
is: HMDB00127
name: D-glucuronate
constant: false
is: SBO:0000247
is: CHEBI:15748
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
type: Species

metaM anth e
has only substance units: false
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
boundary condition: false
is: CHEBI:16567
is: HMDB01123
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: anthranilate
type: Species

metaR r0647
is: SBO:0000176
product: MODEL1310110023#
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
is described by: ECO:0000000
name: Spontaneous reaction
type: Reaction
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110023#_4227044f_757a_46c3_8584_28204c8b646c
is: E7EPT3
name: ALDH7A1
initial amount: NaN
constant: false
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:501
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_e94d2dfe_ecf3_4fd1_865b_076aa8b425a0
initial amount: NaN
is: P24310
constant: false
initial concentration: NaN
name: COX7A1
is encoded by: hsa:1346
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true

metaM em2emgacpail hs r
is: CHEBI:16240
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2 CHARGE: 0
constant: false
initial amount: NaN
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol (H7)
is: HMDB03125

metaR UMPK6
fast: false
is described by: ECO:0000269
product: MODEL1310110023#
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
type: Reaction
name: UMP kinase (dCTP)
reactant: MODEL1310110023#
reversible: true
modifier: MODEL1310110023#

metaR r0236
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
is version of: http://identifiers.org/ec-code/3.5.1.6
type: Reaction
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
fast: false
modifier: MODEL1310110023#
product: MODEL1310110023#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110023#
is described by: ECO:0000000

metaM ser L c
is: HMDB00187
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
initial amount: NaN
type: Species
initial concentration: 1.0
name: L-serine
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:17115

metaM asp L m
initial concentration: 1.0
constant: false
name: L-aspartate(1-)
is: HMDB00191
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
initial amount: NaN
is: CHEBI:29991
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_4e7043d2_182a_466f_b60a_200217d4ca4d
constant: false
initial concentration: NaN
name: _T83654_1_c
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:T83654
initial amount: NaN

metaM dd2coa m
initial concentration: 1.0
has only substance units: false
type: Species
name: trans-dodec-2-enoyl-CoA(4-)
constant: false
boundary condition: false
is: HMDB03712
is: CHEBI:57330
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221

metaM ump g
is: HMDB00288
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial concentration: 1.0
boundary condition: false
name: UMP(2-)
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
constant: false
is: CHEBI:57865

metaM HC02210 e
boundary condition: false
type: Species
name: prostaglandin-d3
is: SBO:0000247
has only substance units: false
is: CHEBI:34939
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1

metaR P4508B13r
reversible: false
product: MODEL1310110023#
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.14.13.95
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (1582.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH and NADPH can both be used)
modifier: MODEL1310110023#
name: sterol 12-alpha-hydroxylase (nadh)

metaR r0915
product: MODEL1310110023#
fast: false
reactant: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
kinetic law: MODEL1310110023#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
is: SBO:0000185

metaR UMPK7
product: MODEL1310110023#
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110023#
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000269
name: UMP kinase (dGTP)

http://identifiers.org/biomodels.db/MODEL1310110023#_3874a1c4_f54e_41de_89da_c18f757612a6
is: SBO:0000252
type: Species
is encoded by: hsa:51181
has only substance units: false
initial concentration: NaN
name: DCXR
is: Q7Z4W1
constant: false
initial amount: NaN
boundary condition: true

metaR r1723
type: Reaction
kinetic law: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000185
reversible: false
reactant: MODEL1310110023#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110023#
fast: false

metaR r1610
reactant: MODEL1310110023#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110023#
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110023#

metaM pail3p hs c
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C04549
is: CHEBI:58088

http://identifiers.org/biomodels.db/MODEL1310110023#_290b9730_c50a_4d08_b4ab_15fb293e843c
is: SBO:0000252
initial amount: NaN
is: Q9UN42
initial concentration: NaN
boundary condition: true
is encoded by: hsa:23439
type: Species
has only substance units: false
constant: false
name: ATP1B4

http://identifiers.org/biomodels.db/MODEL1310110023#_08a6d7a5_73ec_4c5c_9d38_a2c3fb437c5c
constant: false
initial amount: NaN
initial concentration: NaN
name: GSTZ1
boundary condition: true
type: Species
is encoded by: hsa:2954
has only substance units: false
is: SBO:0000252
is: O43708

metaM glcur e
is: HMDB00127
initial concentration: 1.0
has only substance units: false
name: D-glucuronate
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:15748
type: Species
boundary condition: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191

metaR DALAt2r
reversible: true
modifier: MODEL1310110023#
product: MODEL1310110023#
type: Reaction
kinetic law: MODEL1310110023#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
name: D-alanine transport via proton symport
is: SBO:0000185
reactant: MODEL1310110023#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_1d88e797_13ea_4f41_b1e3_1158f334281c
initial amount: NaN
is encoded by: hsa:N63787
type: Species
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
name: _N63787_1_c
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_4eedcde9_1e06_4497_a933_1aff72293801
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:AI761708
name: _AI761708_1_m
initial amount: NaN
type: Species
initial concentration: NaN

metaR GLYCLTDy
type: Reaction
kinetic law: MODEL1310110023#
reversible: false
notes: GENE_ASSOCIATION: (9380.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.79 Confidence Level: 4 AUTHORS: PMID:1252411,PMID:15240345,PMID:2689175 NOTES:JLR
reactant: MODEL1310110023#
modifier: MODEL1310110023#
product: MODEL1310110023#
is described by: ECO:0000269
fast: false
name: Glycolate dehydrogenase (NADP)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.79

http://identifiers.org/biomodels.db/MODEL1310110023#_06ea8dfc_e9b0_497e_bc43_97a03bd908a6
is encoded by: hsa:4707
has only substance units: false
is: O75438
initial concentration: NaN
constant: false
type: Species
name: NDUFB1
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR ALADGLYexR
reversible: true
fast: false
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
modifier: MODEL1310110023#
is: SBO:0000185
name: D-alanine/glycine reversible exchange

metaR r1050
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
kinetic law: MODEL1310110023#
name: Vesicular transport
product: MODEL1310110023#
type: Reaction
reactant: MODEL1310110023#
is: SBO:0000185
reversible: true

metaR GLCNACASE2ly
is version of: http://identifiers.org/ec-code/3.2.1.50
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
product: MODEL1310110023#
kinetic law: MODEL1310110023#
name: alpha-N-acetylglucosaminidase, lysosomal
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
modifier: MODEL1310110023#
fast: false
reactant: MODEL1310110023#
reversible: false

metaM 5aizc c
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:58564
constant: false
notes: FORMULA: C9H11N3O9P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01347 EHMN_ABBREVIATION: C04751
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
is: C04751
initial concentration: 1.0
is: SBO:0000247
is: HMDB06273

metaR CYSALANaEx
type: Reaction
is: SBO:0000185
product: MODEL1310110023#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
name: L-alanine/L-cysteine Na-dependent exchange (Cys-L in)
reversible: false
fast: false
modifier: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_1a5ef776_c808_4e0d_9efc_b3f17735c0fc
name: ADSS
initial concentration: NaN
is: P30520
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
boundary condition: true
is encoded by: hsa:159

metaR PPA
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.6.1.1
is: SBO:0000176
fast: false
reactant: MODEL1310110023#
product: MODEL1310110023#
kinetic law: MODEL1310110023#
reversible: false
name: inorganic diphosphatase
is described by: ECO:0000269
type: Reaction

metaM cspg e l
constant: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
has only substance units: false
is: CHEBI:36005
type: Species
is: HMDB02183
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C45H63N2O54S6X CHARGE: -8

metaR r1051
is described by: ECO:0000000
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
fast: false
name: Vesicular transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
reversible: true
product: MODEL1310110023#
is: SBO:0000185

metaM xol7ah2 m
is: HMDB06893
is: SBO:0000247
initial concentration: 1.0
name: 5beta-cholestane-3alpha,7alpha-diol
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:28047
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_4168bb55_6c21_4456_88df_132dfb15fcce
name: PIGO
boundary condition: true
is: SBO:0000252
type: Species
constant: false
is: Q8TEQ8
initial concentration: NaN
is encoded by: hsa:84720
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_1de3084d_6cb9_431e_aba2_1654c9e10e5b
constant: false
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:AI539321
name: _AI539321_1_c
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaM pentcoa m
initial amount: NaN
is: HMDB13037
initial concentration: 1.0
is: SBO:0000247
is: C00888
has only substance units: false
name: pentanoylcoa
type: Species
notes: FORMULA: C26H40N7O17P3S CHARGE: -4
constant: false
boundary condition: false

metaR ENGASE2ly
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
type: Reaction
name: endo-beta-N-acetylglucosaminidase, lysosomal
kinetic law: MODEL1310110023#
fast: false
product: MODEL1310110023#
is: SBO:0000176
reversible: false

metaR r0797
reversible: true
is: SBO:0000176
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
fast: false
product: MODEL1310110023#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
name: glycine N-choloyltransferase EC:2.3.1.65

http://identifiers.org/biomodels.db/MODEL1310110023#_50ffb4d0_454f_458a_bd47_c05dc5c6535e
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: Q53TV9
has only substance units: false
name: RPE
initial concentration: NaN
is encoded by: hsa:6120

metaR CYTK5n
fast: false
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
is: SBO:0000176
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
name: cytidylate kinase (CMP),nuclear
product: MODEL1310110023#
is described by: ECO:0000269
kinetic law: MODEL1310110023#
reversible: true

metaR EX trp L LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tryptophan exchange
type: Reaction

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

metaM ksii core2 deg9 l
is: CHEBI:12936
is: SBO:0000247
initial amount: NaN
constant: false
name: keratan sulfate II (core 2-linked), degradation product 9
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C30H50N3O20X CHARGE: 0
is: HMDB00143
type: Species

metaR EX succ LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Succinate exchange
type: Reaction

metaR KSII CORE2tly
type: Reaction
is described by: ECO:0000000
reversible: false
name: keratan sulfate II (core 2) transport, extracellular to lysosome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
is: SBO:0000185
reactant: MODEL1310110023#
product: MODEL1310110023#
kinetic law: MODEL1310110023#

metaR EX hdcea LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecenoate (n-C16:1)
type: Reaction

metaR r0796
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110023#
is described by: ECO:0000000
modifier: MODEL1310110023#
reversible: true
fast: false
product: MODEL1310110023#
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_3d1230bf_fbbf_44ff_b191_74c8c5ba0815
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:AA629629
initial amount: NaN
is: SBO:0000252
name: _AA629629_1_m
constant: false

metaR r0795
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.225
modifier: MODEL1310110023#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Unassigned EC Number: 1.5.1.20 Confidence Level: 0 AUTHORS: PMID:1119805,PMID:2383427 NOTES:
name: Spontaneous reaction
product: MODEL1310110023#
is: SBO:0000176
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#

metaR S6TASE3ly
kinetic law: MODEL1310110023#
name: N-acetylglucosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
fast: false
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110023#
type: Reaction
modifier: MODEL1310110023#
reversible: true

metaR GAL3ST11
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.8.2.11
product: MODEL1310110023#
name: Galactosylceramide sulfotransferase
reactant: MODEL1310110023#
is: SBO:0000176
kinetic law: MODEL1310110023#
fast: false
modifier: MODEL1310110023#
reversible: false
notes: GENE_ASSOCIATION: (9514.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 4 AUTHORS: PMID:9030544 NOTES:NJ
type: Reaction

metaM ahdt e
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C9H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C9H16N5O13P3/c10-9-13-7-5(8(17)14-9)12-3(1-11-7)6(16)4(15)2-25-29(21,22)27-30(23,24)26-28(18,19)20/h4,6,15-16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H4,10,11,13,14,17)/p-4/t4-,6+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01367 EHMN_ABBREVIATION: C04895
initial concentration: 1.0
name: 7,8-dihydroneopterin 3'-triphosphate(4-)
is: SBO:0000247
type: Species
is: CHEBI:58462
is: HMDB00980
initial amount: NaN

metaR UMPK2
is described by: ECO:0000269
kinetic law: MODEL1310110023#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110023#
product: MODEL1310110023#
is: SBO:0000176
name: UMP kinase (CTP)
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110023#

metaR SIAASE2ly
is: SBO:0000176
fast: false
product: MODEL1310110023#
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.1.6.4
name: sialidase, lysosomal
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110023#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18

metaR AKR1D
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.3.1.3
is: SBO:0000176
reactant: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
modifier: MODEL1310110023#
type: Reaction
kinetic law: MODEL1310110023#
is described by: ECO:0000269
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110023#_44ff37d9_0b0d_4f5c_bbdc_17c78c0ef39d
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:52
type: Species
is: B5MCC7
initial concentration: NaN
has only substance units: false
name: ACP1
constant: false
boundary condition: true

metaR GLRASE
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 1.1.1.20 Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
fast: false
reactant: MODEL1310110023#
name: glucuronolactone reductase
kinetic law: MODEL1310110023#
product: MODEL1310110023#
is: SBO:0000176
reversible: true
is described by: ECO:0000000

metaR r0911
name: Facilitated diffusion
is described by: ECO:0000000
product: MODEL1310110023#
reactant: MODEL1310110023#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:
reversible: true
fast: false

metaR ALASm
fast: false
product: MODEL1310110023#
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.3.1.29
reactant: MODEL1310110023#
name: 5-aminolevulinate synthase
is version of: http://identifiers.org/ec-code/2.3.1.37
type: Reaction
modifier: MODEL1310110023#
is described by: ECO:0000254
is: SBO:0000176
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD
reversible: false

metaR DM Ser Gly Ala X Gly ly
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser-Gly/Ala-X-Gly(ly)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_78c5308d_e860_4ab0_b149_3c61129b8b31
name: HMGCR
constant: false
has only substance units: false
boundary condition: true
is: P04035
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3156
initial amount: NaN

metaR HOMt4
type: Reaction
notes: GENE_ASSOCIATION: (6541.1) or (84889.1) or (6542.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
fast: false
name: L-homoserine via sodium symport
reactant: MODEL1310110023#
modifier: MODEL1310110023#
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110023#
reversible: false
kinetic law: MODEL1310110023#

metaR SUCD1m
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.5.1
reactant: MODEL1310110023#
is described by: ECO:0000134
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
type: Reaction
name: succinate dehydrogenase
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
fast: false
reversible: true

metaR FAOXC164C163x
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)x
type: Reaction

metaR HAS1
fast: false
modifier: MODEL1310110023#
name: hyaluronan synthase
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.4.1.212
reversible: false
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#

metaR RE0926E
name: RE0926
reactant: MODEL1310110023#
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.17
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
kinetic law: MODEL1310110023#
is: SBO:0000176
product: MODEL1310110023#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_c8b6b03a_ae62_4e70_9ace_dbe3d0e47519
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:8818
has only substance units: false
name: DPM2
boundary condition: true
type: Species
initial concentration: NaN

metaR UMPK3
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110023#
fast: false
reactant: MODEL1310110023#
name: UMP kinase (UTP)
reversible: true
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
is: SBO:0000176
type: Reaction

metaM ksi pre29 g
type: Species
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 29
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C213H340N15O179S9X CHARGE: -10
initial amount: NaN
is: CHEBI:28067

metaM nadh x
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3306
type: Species
is: SBO:0000247
name: Nicotinamide adenine dinucleotide - reduced
is: C00004
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB01487
constant: false
is: CHEBI:57945

metaR ILETA
reactant: MODEL1310110023#
fast: false
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.6.1.42
reversible: true
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
product: MODEL1310110023#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
name: isoleucine transaminase

http://identifiers.org/biomodels.db/MODEL1310110023#_cbd8483e_ffee_4025_99f7_b26992ae520e
type: Species
is encoded by: hsa:2182
is: O60488
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
name: ACSL4
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110023#_bf54e056_54c3_4fab_b153_93cda967c782
name: SULT1A2
initial amount: NaN
boundary condition: true
is encoded by: hsa:6799
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

metaR r2136
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
modifier: MODEL1310110023#
is: SBO:0000185
product: MODEL1310110023#
fast: false
is described by: ECO:0000000
type: Reaction
reversible: false
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110023#_60b89b84_9dc2_447c_9ce8_3790fc40f484
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:54576
name: UGT1A8
initial concentration: NaN
is: Q5DSZ6
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_cf911f5e_0f86_4a4e_9091_c7231fbe7555
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:8897
name: MTMR3
is: SBO:0000252
type: Species
initial amount: NaN

metaR r1585
reactant: MODEL1310110023#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110023#
product: MODEL1310110023#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000

metaR B3GALT3g
is described by: ECO:0000269
modifier: MODEL1310110023#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.79
name: Beta-1,3-galactosyltransferase 3
type: Reaction
notes: GENE_ASSOCIATION: (8706.4) or (8706.1) or (8706.3) or (8706.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.79 Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110023#
reversible: false
fast: false
reactant: MODEL1310110023#
product: MODEL1310110023#

metaM m6masnC g
initial concentration: 1.0
is: HMDB02177
boundary condition: false
notes: FORMULA: C58H97N2O45X CHARGE: 0
constant: false
initial amount: NaN
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: CHEBI:36033
is: SBO:0000247
type: Species
has only substance units: false

metaR r1707
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
name: Y+LAT2 Utilized transport
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: false
product: MODEL1310110023#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_cad0e2a4_14ad_44d6_b825_5a168c2f687a
has only substance units: false
is: P23434
initial concentration: NaN
constant: false
name: GCSH
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:2653

http://identifiers.org/biomodels.db/MODEL1310110023#_49e1aec5_d975_4298_b707_986019768279
type: Species
name: NT5C1B
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: Q96P26
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:93034

http://identifiers.org/biomodels.db/MODEL1310110023#_ec409f2d_20e6_45df_9f80_e5e30031aade
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
is: Q9H936
initial amount: NaN
boundary condition: true
name: SLC25A22
is encoded by: hsa:79751
type: Species

metaM HC01408 m
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:27648
is: SBO:0000247
constant: false
name: 3-Oxohexanoyl-CoA
initial concentration: 1.0

metaR r2137
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000185
modifier: MODEL1310110023#
product: MODEL1310110023#
fast: false

metaM trdrd m
type: Species
is: CHEBI:15967
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
name: Reduced thioredoxin
is: SBO:0000247

metaR EX din LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyinosine
type: Reaction

metaR GLCAASE9ly
product: MODEL1310110023#
reactant: MODEL1310110023#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.2.1.31
name: beta-glucuronidase, lysosomal
type: Reaction
modifier: MODEL1310110023#
reversible: false
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_00e34626_b224_4202_9a78_24a8252b818f
type: Species
is encoded by: hsa:4718
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
is: Q549M5
name: NDUFC2
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_710727b5_c0b6_4b87_872d_2a28adac7840
is encoded by: hsa:4716
name: NDUFB10
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: A8K761
constant: false
boundary condition: true

metaR r1584
product: MODEL1310110023#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110023#
is described by: ECO:0000000
kinetic law: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_d90e945f_e5c0_4501_8738_ec90be74e598
initial amount: NaN
name: ENTPD8
type: Species
boundary condition: true
is: SBO:0000252
is: Q5MY95
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:377841

metaM 3uib c
is: HMDB02031
name: 3-Ureidoisobutyrate
is: CHEBI:1670
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H9N2O3 CHARGE: -1 INCHI: InChI=1S/C5H10N2O3/c1-3(4(8)9)2-7-5(6)10/h3H,2H2,1H3,(H,8,9)(H3,6,7,10) HEPATONET_1.0_ABBREVIATION: HC01371 EHMN_ABBREVIATION: C05100
type: Species

metaR RE0830C
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110023#
name: RE0830
is described by: ECO:0000000
reactant: MODEL1310110023#
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
reversible: true

metaR FAS100COA
modifier: MODEL1310110023#
is: SBO:0000176
reactant: MODEL1310110023#
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
kinetic law: MODEL1310110023#
fast: false
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
name: fatty acyl-CoA synthase (n-C10:0CoA)

metaM dc2coa m
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:61406
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275
type: Species
name: trans-Dec-2-enoyl-CoA

metaR SIAT9g
notes: GENE_ASSOCIATION: (8869.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.9 Confidence Level: 4 AUTHORS: PMID:9822625 NOTES:NJ
product: MODEL1310110023#
name: Lactosylceramide alpha-2,3-sialyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.99.9
reversible: false
is: SBO:0000176
modifier: MODEL1310110023#
type: Reaction
kinetic law: MODEL1310110023#
is described by: ECO:0000000
reactant: MODEL1310110023#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_4cae5bc8_4f08_4a3c_b5cb_53bf0af58795
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:9583
is: Q9Y227
constant: false
name: ENTPD4

metaM C05280 m
boundary condition: false
is: SBO:0000247
name: cis,cis-3,6-Dodecadienoyl-CoA
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280
is: HMDB03952
is: CHEBI:28002
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_4e8b39bb_35ee_4269_99b1_a1b89276d1ac
is encoded by: hsa:6487
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
name: ST3GAL3
is: Q96L53

metaR GTHRDt
is: SBO:0000185
name: Glutathione transport into mitochondria
kinetic law: MODEL1310110023#
is described by: ECO:0000000
reactant: MODEL1310110023#
type: Reaction
product: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
reversible: true

metaR S6T6g
is described by: ECO:0000000
modifier: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110023#
reversible: false
product: MODEL1310110023#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110023#
type: Reaction
is: SBO:0000176

metaR VALTAm
is version of: http://identifiers.org/ec-code/2.6.1.42
reversible: true
kinetic law: MODEL1310110023#
name: valine transaminase, mitochondiral
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
product: MODEL1310110023#
is described by: ECO:0000269
modifier: MODEL1310110023#
reactant: MODEL1310110023#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110023#_3568d44d_496d_47dd_9977_8c5e5c675b86
constant: false
has part: P21953
type: Species
name: DBT:DLD:BCKDHA:BCKDHB
has only substance units: false
has part: P11182
initial concentration: NaN
has part: B4DP47
is encoded by: hsa:594
boundary condition: true
is encoded by: hsa:593
is encoded by: hsa:1629
is: SBO:0000297
initial amount: NaN

metaM ump n
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB00288
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:57865
name: UMP(2-)

metaR EX nrpphrsf LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate derivative of norepinephrine exchange
type: Reaction

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

metaR r1587
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110023#
kinetic law: MODEL1310110023#
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110023#
type: Reaction

metaR RE3004M
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110023#
product: MODEL1310110023#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
name: RE3004
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_20903346_74c3_43b2_8fbd_dd18879e4bee
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:8897
type: Species
name: MTMR3
has only substance units: false
is: SBO:0000252

metaM dopasf e
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
constant: false
boundary condition: false
name: dopamine 3-O-sulfate
initial concentration: 1.0
is: CHEBI:37946
initial amount: NaN
is: HMDB06275
has only substance units: false
type: Species
is: SBO:0000247

metaM lneldccoa c
initial amount: NaN
type: Species
notes: FORMULA: C39H62N7O17P3S CHARGE: -4
boundary condition: false
name: linoelaidyl coenzyme A
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/9543677
has only substance units: false
initial concentration: 1.0
is: HMDB06521
constant: false

metaM C05965 e
initial concentration: 1.0
is: HMDB04243
boundary condition: false
has only substance units: false
is: CHEBI:57444
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
name: 12(S)-HPETE(1-)
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965

metaR TRDR2
reversible: false
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (7296.1) or (7296.4) or (7296.2) or (7296.3) SUBSYSTEM: Miscellaneous EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:12435734,PMID:8577704,PMID:8999974 NOTES:Xia et al, 2003, JBC, 2141-2146
is version of: http://identifiers.org/ec-code/1.8.1.9
modifier: MODEL1310110023#
product: MODEL1310110023#
is: SBO:0000176
kinetic law: MODEL1310110023#
is described by: ECO:0000000
type: Reaction
fast: false
name: Thioredoxin (ubiquinone 10) reductase (NADPH)

metaM na1 r
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
initial amount: NaN
type: Species
is: CHEBI:29101
is: HMDB00588
name: sodium(1+)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110023#_d3d49827_ec60_4bb7_9bf1_70251ea2aac6
constant: false
type: Species
name: SDHA
is encoded by: hsa:6389
initial concentration: NaN
is: P31040
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR r1586
is: SBO:0000185
product: MODEL1310110023#
kinetic law: MODEL1310110023#
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110023#
is described by: ECO:0000000

metaM pchol hs r
type: Species
constant: false
boundary condition: false
is: CHEBI:16110
initial amount: NaN
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: Phosphatidylcholine

metaR ADK1
reactant: MODEL1310110023#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.3
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
fast: false
product: MODEL1310110023#
name: adenylate kinase
type: Reaction

metaR TAUBETAtc
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of taurine into the intestinal cells by beta transport system
type: Reaction

metaR r2139
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110023#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110023#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_3ee78429_c7fb_4594_8dc0_b3d28f913c1e
is: SBO:0000252
constant: false
is: P82251
name: SLC7A9
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:11136
initial amount: NaN
initial concentration: NaN

metaR NRPPHRSFt
kinetic law: MODEL1310110023#
fast: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB
reversible: false
reactant: MODEL1310110023#
product: MODEL1310110023#
name: norepinephrine sulfate transport (diffusion)

metaR r2132
reversible: true
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
modifier: MODEL1310110023#
is: SBO:0000185
product: MODEL1310110023#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110023#

metaR AG13T9g
is: SBO:0000176
modifier: MODEL1310110023#
fast: false
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (146712.1) or (79369.1) or (10331.1) or (374907.1) or (10678.2) or (374907.2) or (10678.1) or (11041.1) or (93010.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
reversible: false
type: Reaction
product: MODEL1310110023#

metaM Rtotal3 c
boundary condition: false
name: R total 3 position
is: HMDB01448
has only substance units: false
is: CHEBI:16189
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: CO2FULLR3 CHARGE: -1
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110023#_2a7d582f_594e_4336_a7e3_e8fda89150ed
constant: false
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: SLC2A9
is encoded by: hsa:56606
initial amount: NaN

metaM dcholcoa c
boundary condition: false
initial amount: NaN
is: CHEBI:28701
type: Species
name: chenodeoxycholoyl coenzyme a
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
constant: false
is: SBO:0000247
is: HMDB06292
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_b9224829_6ffe_4e9f_b3e6_6d2174cbbc57
initial concentration: NaN
initial amount: NaN
name: SULT1A1
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:6817
has only substance units: false
type: Species

metaR r1589
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110023#
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110023#
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_c1e8044b_7f62_4941_ace0_76f91732e2a1
initial amount: NaN
constant: false
is encoded by: hsa:5281
initial concentration: NaN
boundary condition: true
is: Q6IB04
name: PIGF
is: SBO:0000252
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_2c04d44c_0c1a_4775_9f09_d7f980c4738d
is: Q6ZMU0
type: Species
initial amount: NaN
name: ALAD
constant: false
has only substance units: false
is encoded by: hsa:210
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaR PE HStm
reactant: MODEL1310110023#
name: phosphatidylethanolamine scramblase
type: Reaction
kinetic law: MODEL1310110023#
reversible: true
product: MODEL1310110023#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:
fast: false
is: SBO:0000185

metaM udp r
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: C00015
constant: false
is: HMDB00295
name: UDP
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: SBO:0000247
is: CHEBI:58223
type: Species

metaM fn2m2masn g
type: Species
name: N4-{N-Acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine
has only substance units: false
initial amount: NaN
is: CHEBI:32984
boundary condition: false
notes: FORMULA: C56H93N4O39X CHARGE: 0 INCHI: InChI=1S/C60H100N6O42/c1-14-32(77)42(87)45(90)57(96-14)94-13-26-48(40(85)28(62-15(2)72)52(97-26)66-27(76)6-19(61)53(92)93)104-56-31(65-18(5)75)41(86)47(24(11-71)102-56)105-58-46(91)49(106-60-51(44(89)36(81)23(10-70)101-60)108-55-30(64-17(4)74)39(84)34(79)21(8-68)99-55)37(82)25(103-58)12-95-59-50(43(88)35(80)22(9-69)100-59)107-54-29(63-16(3)73)38(83)33(78)20(7-67)98-54/h14,19-26,28-52,54-60,67-71,77-91H,6-13,61H2,1-5H3,(H,62,72)(H,63,73)(H,64,74)(H,65,75)(H,66,76)(H,92,93)/t14-,19-,20+,21+,22+,23+,24+,25+,26+,28+,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43-,44-,45-,46-,47+,48+,49-,50-,51-,52+,54-,55-,56-,57+,58-,59-,60+/m0/s1
constant: false
is: SBO:0000247
initial concentration: 1.0

metaR r2133
product: MODEL1310110023#
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110023#_8499b894_1891_457b_b0ab_3a03479cecc7
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
name: IDS
is encoded by: hsa:3423
is: B4DGD7

metaM C02528 r
is: SBO:0000247
boundary condition: false
is: CHEBI:36234
is: HMDB00518
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
name: chenodeoxycholate
initial concentration: 1.0
type: Species

metaR ADK3
type: Reaction
product: MODEL1310110023#
reactant: MODEL1310110023#
reversible: true
is described by: ECO:0000269
is: SBO:0000176
name: adentylate kinase (GTP)
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.4.3
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
fast: false

metaR r1588
type: Reaction
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110023#
reactant: MODEL1310110023#
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR DNDPt35m
name: dGDP transport via dADP antiport
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110023#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110023#
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_267434fa_c269_45d3_98bd_acc480b2a65b
has only substance units: false
initial amount: NaN
boundary condition: true
name: ABCB4
is: SBO:0000252
is encoded by: hsa:5244
initial concentration: NaN
type: Species
is: A4D1D5
constant: false

metaM m4mpdol U r
boundary condition: false
constant: false
is: SBO:0000247
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
has only substance units: false
initial amount: NaN
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
type: Species
initial concentration: 1.0
is: CHEBI:37633

http://identifiers.org/biomodels.db/MODEL1310110023#_38e26ab2_309e_4ef2_bacb_b508451cf8dc
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:4712
boundary condition: true
name: NDUFB6
is: Q5VYT2
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR CYTK10n
reactant: MODEL1310110023#
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
name: cytidylate kinase (CMP,dGTP),nuclear
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110023#
is described by: ECO:0000269
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110023#_75207ac1_6516_4222_a959_84e9f4bc2c41
has only substance units: false
constant: false
is: A0S0A7
is encoded by: hsa:4846
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: NOS3
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110023#_515fa7bd_f885_4872_b196_31cefb4dfd20
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:29085
name: PHPT1
constant: false
is: Q9P019
boundary condition: true
has only substance units: false
initial concentration: NaN

metaM cyan e
name: hydrogen cyanide
boundary condition: false
is: HMDB02084
is: CHEBI:18407
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326

metaR NACHEXA17ly
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase A, lysosomal
kinetic law: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
modifier: MODEL1310110023#
product: MODEL1310110023#
is: SBO:0000176
reactant: MODEL1310110023#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_4758fbf6_00b5_4eee_a345_33d16226f42f
is encoded by: hsa:204
initial amount: NaN
is: SBO:0000252
name: AK2
type: Species
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true

metaM s2l2n2m2mn l
name: de-Fuc, reducing GlcNAc removed form of PA6 (w/o peptide linkage)
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C76H123N5O57 CHARGE: -2
is: SBO:0000247
boundary condition: false
is: CHEBI:36033
has only substance units: false
initial amount: NaN
is: HMDB02177

metaR CBASPte
name: Transport of N-carbamoyl-L-aspartate
fast: false
product: MODEL1310110023#
is: SBO:0000185
is described by: ECO:0000134
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110023#
type: Reaction
reversible: true

metaR PHEACGLNt
is described by: ECO:0000000
name: PHEACGLN extracellular transport via diffusion
reactant: MODEL1310110023#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110023#
reversible: true
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14681857 NOTES:SAB
type: Reaction

metaR CYTDK1
kinetic law: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: ATPcytidine 5-phosphotransferase
is version of: http://identifiers.org/ec-code/2.7.1.48
reversible: false
fast: false
is described by: ECO:0000254
modifier: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110023#_47032f3b_055d_496a_a841_a5e54fa23eb9
initial concentration: NaN
is encoded by: hsa:1582
type: Species
initial amount: NaN
constant: false
is: Q9UNU6
has only substance units: false
name: CYP8B1
boundary condition: true
is: SBO:0000252

metaM dec24dicoa m
constant: false
name: 2,4-decadienoylcoa
type: Species
is: HMDB01168
initial amount: NaN
has only substance units: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaM ump r
name: UMP
initial amount: NaN
is: CHEBI:57865
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00288
boundary condition: false
type: Species

metaM doldp U r
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
name: Dolichol diphosphate, human uterine homolog
notes: FORMULA: C1025H1670O70P20 CHARGE: -30 INCHI: InChI=1S/C25H46O7P2/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-31-34(29,30)32-33(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H,29,30)(H2,26,27,28)/b22-13+,23-15+,24-17-
type: Species
is: CHEBI:15750

metaM nadh c
constant: false
is: HMDB01487
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: C00004
is: http://identifiers.org/pubchem.compound/3306
has only substance units: false
initial concentration: 1.0
is: CHEBI:57945
type: Species
name: Nicotinamide adenine dinucleotide - reduced

metaR HDCACBP
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaR r0226
is described by: ECO:0000000
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
type: Reaction
reversible: false
product: MODEL1310110023#
name: 5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
reactant: MODEL1310110023#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:6882460,PMID:962851 NOTES:

metaM dcdp c
constant: false
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: dCDP
is: C00705
boundary condition: false
is: HMDB01245
is: CHEBI:58593
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705

http://identifiers.org/biomodels.db/MODEL1310110023#_e8fb5dab_0e67_4cc5_a9ca_013e0538014f
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:55350
name: VNN3
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_7096e7c9_b2a9_4cfb_bea9_cab5dcdaf90a
initial amount: NaN
is: Q8NB10
is encoded by: hsa:5137
type: Species
name: PDE1C
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaM 5forthf c
is: C00664
is: SBO:0000247
name: 5-Formiminotetrahydrofolate
is: HMDB01534
initial amount: NaN
has only substance units: false
is: CHEBI:57456
type: Species
notes: FORMULA: C20H22N8O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00483 EHMN_ABBREVIATION: C00664
initial concentration: 1.0
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110023#_57975d29_a074_443d_a146_431c73959355
initial concentration: NaN
is: E9PNG0
is: SBO:0000252
initial amount: NaN
name: AMPD2
boundary condition: true
type: Species
constant: false
is encoded by: hsa:271
has only substance units: false

metaM xylu L c
initial amount: NaN
is: CHEBI:17399
is: HMDB00751
constant: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
is: SBO:0000247
name: L-xylulose
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_50e30b73_a2f9_4d8f_90ee_f2182c981987
has only substance units: false
type: Species
is: O95167
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4696
constant: false
boundary condition: true
name: NDUFA3

metaR ASPte
name: diffusion of aspartate into blood
kinetic law: MODEL1310110023#
fast: false
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. no such transporter could be found so diffusion reaction is assumed. NOTES:
type: Reaction
is described by: ECO:0000134
is: SBO:0000185
reversible: true
product: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_136b43d7_1f6c_4881_ac40_c85c66787b05
type: Species
is: Q99714
is encoded by: hsa:3028
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
name: HSD17B10
initial amount: NaN
is: SBO:0000252

metaR RE1796M
product: MODEL1310110023#
kinetic law: MODEL1310110023#
fast: false
reactant: MODEL1310110023#
is: SBO:0000176
modifier: MODEL1310110023#
is described by: ECO:0000000
name: RE1796
is version of: http://identifiers.org/ec-code/1.1.1.145
reversible: true
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
type: Reaction

metaR MECOAS1m
reversible: true
type: Reaction
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/6.2.1.4
product: MODEL1310110023#
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
name: mesaconate--CoA ligase (GDP-forming)
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
reactant: MODEL1310110023#

metaR r2366
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000000
fast: false
product: MODEL1310110023#
type: Reaction
name: Organic anion transporter 5 Utilized transport

metaM CE5120 m
initial concentration: 1.0
constant: false
is: CHEBI:57923
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,14-15,22-24,28-30,34,45-46H,4-7,10-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5120
name: trans-2-cis-8-tetradecadienoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110023#_196a92de_cb29_45ba_8b1f_26c59d8ee2e8
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
is: P14618
name: PKM2
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5315
constant: false

metaM udp n
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
initial amount: NaN
type: Species
has only substance units: false
name: UDP(3-)
constant: false
is: HMDB00295
boundary condition: false
initial concentration: 1.0
is: CHEBI:58223
is: SBO:0000247

metaM 5htrp c
constant: false
is: HMDB00472
initial amount: NaN
name: 5-hydroxy-L-tryptophan
is: SBO:0000247
type: Species
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643
has only substance units: false
boundary condition: false
is: CHEBI:17780
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110023#_4bdcd296_2d1a_424a_beac_9e87e9701932
constant: false
initial concentration: NaN
name: ST3GAL3
is encoded by: hsa:6487
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_db0d6d92_f851_49fc_b6bd_3b4b7ff8014c
is: SBO:0000252
is encoded by: hsa:55753
boundary condition: true
has only substance units: false
is: Q9ULD0
name: OGDHL
initial amount: NaN
constant: false
initial concentration: NaN
type: Species

metaM for e
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:15740
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
boundary condition: false
has only substance units: false
is: HMDB00142
is: SBO:0000247
name: formate
initial amount: NaN

metaM na1 x
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:29101
is: HMDB00588
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
has only substance units: false
name: sodium(1+)

metaM octe5coa m
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
name: 5-octenoylcoa
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_c5f65de2_9b2c_41b4_b7b9_2dac7a9f0fe8
boundary condition: true
initial amount: NaN
name: DEGS1
initial concentration: NaN
constant: false
is: O15121
has only substance units: false
is: SBO:0000252
is encoded by: hsa:8560
type: Species

metaR r2367
is: SBO:0000185
reactant: MODEL1310110023#
fast: false
kinetic law: MODEL1310110023#
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction
name: Organic anion transporter 5 Utilized transport

metaM itacon m
is: HMDB02092
initial concentration: 1.0
boundary condition: false
type: Species
name: itaconate(2-)
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:17240
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_1fa1670c_b280_49eb_8350_7965758ed28f
has only substance units: false
initial concentration: NaN
name: _AI653169_1_c
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AI653169
constant: false
type: Species

metaR PRISTCOAtx
reversible: true
kinetic law: MODEL1310110023#
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110023#
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ
name: pristcoa peroxisomal transport
is: SBO:0000185

metaM ksii core4 pre10 g
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 10
is: CHEBI:28067
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C89H143N7O69S2X CHARGE: -3
has only substance units: false
type: Species
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110023#_1ed102a8_99dd_4836_a03a_f19563c46e75
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
name: HADHB
type: Species
is encoded by: hsa:3032
initial amount: NaN
is: P55084

metaR LTC4Sr
reactant: MODEL1310110023#
is described by: ECO:0000269
fast: false
name: Leukotriene C4 synthase
modifier: MODEL1310110023#
reversible: false
notes: GENE_ASSOCIATION: (4056.1) or (4259.1) or (4056.2) or (4258.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 4.4.1.20 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:previous EC 2.5.1.37 EC: 4.4.1.20 NJ
is version of: http://identifiers.org/ec-code/2.5.1.18
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/4.4.1.20
product: MODEL1310110023#

metaM od2coa c
has only substance units: false
is: CHEBI:50570
is: C16218
is: SBO:0000247
type: Species
name: trans-Octadec-2-enoyl-CoA
boundary condition: false
is: HMDB06529
constant: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: CE2244
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_acb1d8af_cb7d_48a5_a5bb_11d584c14cf0
is: P43353
initial concentration: NaN
is encoded by: hsa:221
name: ALDH3B1
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN

metaR r2368
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
reactant: MODEL1310110023#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110023#
product: MODEL1310110023#

metaM dcholcoa r
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
name: chenodeoxycholoyl coenzyme a
initial amount: NaN
is: CHEBI:28701
type: Species
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB06292
initial concentration: 1.0

metaR ICDHyp
notes: GENE_ASSOCIATION: (3417.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:10521434 NOTES:Strathern indicates this reaction as irreversible. It may be reversible. Location is the peroxisomal matrix (MIPS). IF
is version of: http://identifiers.org/ec-code/1.1.1.42
is described by: ECO:0000269
reactant: MODEL1310110023#
fast: false
kinetic law: MODEL1310110023#
product: MODEL1310110023#
name: Isocitrate dehydrogenase (NADP+)
is: SBO:0000176
type: Reaction
modifier: MODEL1310110023#
reversible: false

metaR DCSPTN1COAtx
is described by: ECO:0000000
type: Reaction
product: MODEL1310110023#
name: fatty acid intracellular transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
kinetic law: MODEL1310110023#
reversible: true
fast: false
reactant: MODEL1310110023#

metaM retinal 11 cis c
initial concentration: 1.0
name: 11-cis-retinal
constant: false
initial amount: NaN
is: CHEBI:16066
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
is: HMDB02152

metaM odecoa m
is: HMDB01322
name: Octadecenoyl-CoA (n-C18:1CoA)
boundary condition: false
is: SBO:0000247
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:57387

metaR r2369
reactant: MODEL1310110023#
reversible: true
name: Organic anion transporter 5 Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110023#
fast: false
is: SBO:0000185
product: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_59071346_fd11_4566_8049_18dc071fcd0a
constant: false
name: _AI694761_1_c
initial concentration: NaN
is encoded by: hsa:AI694761
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR GLCURtly
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD
is: SBO:0000185
reversible: true
reactant: MODEL1310110023#
name: glucuronate transport into lysososme
fast: false
kinetic law: MODEL1310110023#
product: MODEL1310110023#
modifier: MODEL1310110023#
type: Reaction

metaM for c
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
name: Formate
is: HMDB00142
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:15740
constant: false
is: C00058

metaM arach c
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
name: arachidate
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
constant: false
is: HMDB02212
has only substance units: false
is: CHEBI:32360
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_065e66e8_8a19_4895_85b9_d40663687cec
initial concentration: NaN
constant: false
is: P07195
is encoded by: hsa:3945
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: LDHB
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_016bcf9b_88e1_4334_bff4_871d8eb5ad54
boundary condition: true
is: P00414
initial concentration: NaN
constant: false
is encoded by: hsa:4514
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: COX3

metaR RE1342C
fast: false
name: RE1342
is described by: ECO:0000000
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
kinetic law: MODEL1310110023#
reversible: true
reactant: MODEL1310110023#
type: Reaction
is: SBO:0000176

metaM dopa e
has only substance units: false
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
initial concentration: 1.0
initial amount: NaN
is: HMDB00073
is: SBO:0000247
constant: false
name: dopaminium(1+)
type: Species
is: CHEBI:59905
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110023#_093dc33b_290d_47df_9b3d_6a546e383b47
initial amount: NaN
is: Q96NR8
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:145226
type: Species
name: RDH12
has only substance units: false

metaR r1581
reactant: MODEL1310110023#
fast: false
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110023#
is described by: ECO:0000000
product: MODEL1310110023#

metaR r2362
name: Organic anion transporter 5 Utilized transport
fast: false
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110023#
is described by: ECO:0000000
product: MODEL1310110023#
is: SBO:0000185
reversible: true
type: Reaction

metaM dopasf c
initial amount: NaN
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
name: dopamine 3-O-sulfate
is: HMDB06275
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:37946
constant: false
initial concentration: 1.0

metaM dcdp m
constant: false
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
name: dCDP(3-)
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:58593
initial concentration: 1.0
is: HMDB01245
is: SBO:0000247

metaM HC02213 c
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: prostaglandin-e3
type: Species
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
is: CHEBI:28031
constant: false

metaM gacpail hs c
is: CHEBI:61548
has only substance units: false
is: HMDB01401
is: C00092
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
is: SBO:0000247
boundary condition: false
name: glucosaminyl-acylphosphatidylinositol
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_5e49d4b1_b5af_4b6f_9630_12e60e3c49ba
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:9374
name: PPT2
is: Q9UMR5
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_815e5853_f7f7_4b3c_8f98_48e4024d230e
initial amount: NaN
type: Species
is encoded by: hsa:AA177072
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
name: _AA177072_1_c
initial concentration: NaN

metaR OCD11COACPT1
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_63ed9839_3d03_4637_9da1_6062f50392a7
is: P13073
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:1327
has only substance units: false
type: Species
name: COX4I1
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_3bc72d3b_1efb_4a35_946d_619408340eb3
type: Species
initial concentration: NaN
name: COX5A
is: P20674
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:9377

metaM arach e
has only substance units: false
type: Species
is: HMDB02212
is: CHEBI:32360
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
name: arachidate
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102

metaR FAOXC204C205x
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:4-->C20:5)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_5609e4d4_e55f_4b97_bbc7_07827f3a6d3c
type: Species
name: GALE
initial amount: NaN
is encoded by: hsa:2582
constant: false
initial concentration: NaN
is: Q38G75
has only substance units: false
boundary condition: true
is: SBO:0000252

metaM dcdp n
initial concentration: 1.0
is: HMDB01245
type: Species
has only substance units: false
is: CHEBI:58593
is: SBO:0000247
constant: false
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
name: dCDP(3-)
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110023#_76db8b6e_ad04_4472_83ae_f0086830a6c0
is: SBO:0000252
name: LDHAL6B
constant: false
is: Q9BYZ2
is encoded by: hsa:92483
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species

metaR r1580
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110023#
type: Reaction
product: MODEL1310110023#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110023#
fast: false

metaR r2363
reversible: true
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
is: SBO:0000185
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
name: Organic anion transporter 5 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110023#_592dbe62_5a0e_4098_b772_99cc80a84a76
type: Species
boundary condition: true
is: SBO:0000252
constant: false
is: Q6P9G0
name: CYB5D1
initial concentration: NaN
has only substance units: false
is encoded by: hsa:124637
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_db4841db_5df5_41e1_aac2_5f430c2e6fd8
is: Q59FD4
boundary condition: true
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
name: HK1
initial amount: NaN
is encoded by: hsa:3098
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_6504aed3_c883_4469_8d9b_513c5de9fef4
constant: false
has only substance units: false
name: CPT1C
is: Q8TCG5
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:126129
initial concentration: NaN
boundary condition: true
type: Species

metaR NTP3e
reactant: MODEL1310110023#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.1.6
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.15 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
kinetic law: MODEL1310110023#
reversible: false
name: nucleoside-triphosphatase (GTP)
fast: false
modifier: MODEL1310110023#

metaM m8masn r
notes: FORMULA: C70H117N2O55X CHARGE: 0
type: Species
has only substance units: false
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
is: C05876

metaR RE0830N
reversible: true
modifier: MODEL1310110023#
reactant: MODEL1310110023#
fast: false
is: SBO:0000176
name: RE0830
is described by: ECO:0000000
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/4.2.1.96
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_00d97bf0_4950_4b03_9c12_823872ad49b5
name: NME7
boundary condition: true
is encoded by: hsa:29922
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
constant: false

metaM odecoa r
is: SBO:0000247
type: Species
name: oleoyl-CoA(4-)
boundary condition: false
initial amount: NaN
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,26-28,32-34,38,49-50H,4-10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-/t28-,32-,33-,34+,38-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
is: CHEBI:57387
is: HMDB01322
has only substance units: false
initial concentration: 1.0
constant: false

metaM cyan m
initial amount: NaN
type: Species
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB02084
is: CHEBI:18407
is: SBO:0000247
boundary condition: false
name: hydrogen cyanide

metaR RE2349C
type: Reaction
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES:IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C
fast: false
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.6.1.64
is described by: ECO:0000000
product: MODEL1310110023#
name: RE2349
modifier: MODEL1310110023#
reversible: true
is: SBO:0000176

metaR VALtec
fast: false
product: MODEL1310110023#
reversible: true
kinetic law: MODEL1310110023#
name: L-valine transport via diffusion (extracellular to cytosol)
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
modifier: MODEL1310110023#
reactant: MODEL1310110023#

metaR ACP1 FMN
reactant: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: (52.1) or (52.3) or (52.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:8522318 NOTES:INVALID ECO TERM: IFH
product: MODEL1310110023#
type: Reaction
modifier: MODEL1310110023#
reversible: false
is described by: ECO:0000254
name: acid phosphatase (FMN)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.2
kinetic law: MODEL1310110023#

metaR r2364
fast: false
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110023#
is described by: ECO:0000000
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
type: Reaction
product: MODEL1310110023#
reversible: true

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

metaR DNDPt9m
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
name: dADP transport via dTDP antiport
reversible: false
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110023#
is described by: ECO:0000269
fast: false
is: SBO:0000185
type: Reaction

metaM dopa c
initial concentration: 1.0
initial amount: NaN
is: HMDB00073
name: dopaminium(1+)
is: SBO:0000247
type: Species
boundary condition: false
constant: false
is: CHEBI:59905
has only substance units: false
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758

metaR r1583
reactant: MODEL1310110023#
type: Reaction
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110023#
product: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_df03fd35_d582_4789_811a_f72abf2eabf8
has only substance units: false
initial concentration: NaN
name: AGPAT4
constant: false
is: Q9NRZ5
initial amount: NaN
is encoded by: hsa:56895
is: SBO:0000252
boundary condition: true
type: Species

metaM sphings c
initial concentration: 1.0
name: sphingosine(1+)
has only substance units: false
initial amount: NaN
is: HMDB00252
type: Species
boundary condition: false
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
is: SBO:0000247
constant: false
is: CHEBI:57756

metaR r0339
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
modifier: MODEL1310110023#
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.22
is version of: http://identifiers.org/ec-code/3.1.2.2
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
kinetic law: MODEL1310110023#
is: SBO:0000176
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.3.1.65
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110023#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_12724a7f_28b7_4138_91d7_ecaebc2e1267
type: Species
initial amount: NaN
is encoded by: hsa:6916
initial concentration: NaN
constant: false
boundary condition: true
name: TBXAS1
has only substance units: false
is: SBO:0000252
is: Q53F23

http://identifiers.org/biomodels.db/MODEL1310110023#_d2c08def_9ecb_4346_a3f5_28ea50d8ee4b
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
name: _AA532636_1_m
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:AA532636

metaR LEUKTRB4t
name: leukotriene B4 transport
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
is: SBO:0000185
product: MODEL1310110023#
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#

metaR GLCtg
reactant: MODEL1310110023#
type: Reaction
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reversible: true
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (6513.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15384581 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000269
fast: false
name: glucose transport, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110023#_06c2a6a9_6ccf_4ab5_a9f7_4808711ed74d
constant: false
has only substance units: false
type: Species
is: Q86VV3
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:953
boundary condition: true
name: ENTPD1

metaR r2365
reactant: MODEL1310110023#
product: MODEL1310110023#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
reversible: true
name: Organic anion transporter 5 Utilized transport
type: Reaction

metaM xoldioloneh c
is: SBO:0000247
is: CHEBI:2288
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-18,20-25,29-30H,6-15H2,1-5H3/t17-,18+,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01462 EHMN_ABBREVIATION: C05453
has only substance units: false
constant: false
is: HMDB06887
initial amount: NaN
initial concentration: 1.0
name: 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one
type: Species
boundary condition: false

metaM udp l
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: CHEBI:58223
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB00295
name: UDP(3-)
boundary condition: false

metaR r2371
type: Reaction
product: MODEL1310110023#
is: SBO:0000185
reactant: MODEL1310110023#
fast: false
reversible: true
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

http://identifiers.org/biomodels.db/MODEL1310110023#_5b984231_1370_48b5_88ce_a7ca5450e6a1
constant: false
name: HSD3B1
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: P14060
is: SBO:0000252
is encoded by: hsa:3283
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_c42f286e_681a_45fb_b45a_c310d6c19b4a
is: A7E2E5
name: PDE3B
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:5140
initial amount: NaN
constant: false
boundary condition: true

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_cbde1f55_0245_4e77_86a8_a67e37b5e1b6
is: SBO:0000252
has only substance units: false
is: B7Z5T8
type: Species
boundary condition: true
name: CPT1B
constant: false
is encoded by: hsa:1375
initial concentration: NaN
initial amount: NaN

metaM g3p c
name: Glyceraldehyde 3-phosphate
is: C00661
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/3930
is: CHEBI:58027
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
is: HMDB01112
has only substance units: false

metaR r0650
reversible: true
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
is version of: http://identifiers.org/ec-code/4.1.1.36
is: SBO:0000176
type: Reaction
fast: false
product: MODEL1310110023#
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
is described by: ECO:0000000

metaM meoh e
notes: FORMULA: CH4O1 CHARGE: 0 INCHI: InChI=1S/CH4O/c1-2/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00130 EHMN_ABBREVIATION: C00132
name: methanol
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB01875
is: CHEBI:17790

metaM dpcoa e
has only substance units: false
initial concentration: 1.0
name: Dephospho-CoA
is: CHEBI:57328
is: C00882
constant: false
is: HMDB01373
type: Species
boundary condition: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
initial amount: NaN
is: SBO:0000247

metaM m2emgacpail hs r
notes: FORMULA: C51H94N2O32P2FULLRCO2FULLR2CO2 CHARGE: 0
type: Species
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/3380
name: (dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (H6)
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: C00080
is: CHEBI:24636
boundary condition: false

metaM CE2431 m
initial amount: NaN
name: cis-deca-4-enoyl-CoA
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
is: CHEBI:57795
constant: false
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaR r1605
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110023#
fast: false
reactant: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110023#

metaR GALASE4ly
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false
name: beta-galactosidase, lysosomal
type: Reaction

metaR AKGMALtm
fast: false
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
product: MODEL1310110023#
reactant: MODEL1310110023#
name: alpha-ketoglutarate/malate transporter
reversible: true
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_3577aea5_f3f0_48b1_a186_498ff510ad0a
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
name: SPHK2
constant: false
boundary condition: true
is: Q9NRA0
is encoded by: hsa:56848
is: SBO:0000252

metaM eicostetcoa c
is: C16164
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
boundary condition: false
is: SBO:0000247
name: eicosatetranoyl coenzyme A

metaM meoh c
is: CHEBI:17790
initial concentration: 1.0
is: HMDB01875
type: Species
initial amount: NaN
is: SBO:0000247
name: methanol
has only substance units: false
constant: false
notes: FORMULA: CH4O1 CHARGE: 0 INCHI: InChI=1S/CH4O/c1-2/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00130 EHMN_ABBREVIATION: C00132
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110023#_a630ed6d_62ef_4c64_a737_547d20f4704d
name: SLC25A18
has only substance units: false
initial concentration: NaN
is encoded by: hsa:83733
initial amount: NaN
is: Q9H1K4
type: Species
boundary condition: true
is: SBO:0000252
constant: false

metaM pnto R c
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
type: Species
is: HMDB00210
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: (R)-Pantothenate
constant: false
is: CHEBI:7916
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110023#_6da419d7_77bc_43e2_86c9_d27548fb6b66
type: Species
is encoded by: hsa:AU149534
constant: false
initial concentration: NaN
name: _AU149534_1_e
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR MI134P4P
name: inositol-1,3,4-trisphosphate 4-phosphatase
is described by: ECO:0000000
reversible: false
product: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
fast: false
type: Reaction
kinetic law: MODEL1310110023#
is: SBO:0000176

metaM CE2418 m
initial concentration: 1.0
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
type: Species
is: CHEBI:28387
boundary condition: false
is: SBO:0000247
is: HMDB11123
initial amount: NaN
has only substance units: false
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
constant: false

metaR r1606
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110023#
is described by: ECO:0000000
kinetic law: MODEL1310110023#
fast: false
reactant: MODEL1310110023#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110023#_32a06245_2324_4452_9be8_d2156729fb88
boundary condition: true
constant: false
is encoded by: hsa:158
is: SBO:0000252
is: P30566
name: ADSL
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species

metaR RE1796R
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.145
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
product: MODEL1310110023#
kinetic law: MODEL1310110023#
is: SBO:0000176
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110023#
name: RE1796
reactant: MODEL1310110023#

metaR r0909
is: SBO:0000185
reversible: true
type: Reaction
reactant: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
name: Transport reaction
product: MODEL1310110023#
kinetic law: MODEL1310110023#
is described by: ECO:0000000

metaR OAGD3te
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110023#
type: Reaction
reactant: MODEL1310110023#
name: oagd3 hs transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
kinetic law: MODEL1310110023#
is described by: ECO:0000000

metaR r2373
is: SBO:0000185
reversible: true
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
product: MODEL1310110023#
kinetic law: MODEL1310110023#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_aafea3ba_5f0d_4151_8b1b_9b45fb32448e
constant: false
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
name: PDE9A
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5152

metaR r1607
type: Reaction
reactant: MODEL1310110023#
is described by: ECO:0000000
kinetic law: MODEL1310110023#
is: SBO:0000185
product: MODEL1310110023#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_3b04fae7_c049_464b_ae97_9f4507c0e459
initial concentration: NaN
is encoded by: hsa:8613
boundary condition: true
constant: false
initial amount: NaN
is: O14495
name: PPAP2B
is: SBO:0000252
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_d40133cf_aa1e_4286_aa54_a62cbbdc90f9
initial concentration: NaN
constant: false
is encoded by: hsa:8818
has only substance units: false
name: DPM2
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true

metaR BTNt2
name: Biotin reversible transport via proton symport
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD
kinetic law: MODEL1310110023#
fast: false
reversible: true
reactant: MODEL1310110023#
is described by: ECO:0000269
modifier: MODEL1310110023#
product: MODEL1310110023#
is: SBO:0000185

metaM dpcoa c
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
has only substance units: false
is: C00882
name: Dephospho-CoA
is: HMDB01373
is: SBO:0000247
is: CHEBI:57328
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
initial amount: NaN

metaR M1316Mg
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
reversible: false
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.2.1.114
notes: GENE_ASSOCIATION: (4124.1) or (4122.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.114 Confidence Level: 0 AUTHORS: PMID:8524845 NOTES:NCD
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
fast: false

metaR GLNS
type: Reaction
product: MODEL1310110023#
fast: false
is described by: ECO:0000254
is: SBO:0000176
reversible: false
modifier: MODEL1310110023#
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/4.1.1.15
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110023#
name: glutamine synthetase

metaM homoval m
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
is: HMDB00118
name: Homovanillate
constant: false
is: SBO:0000247
notes: FORMULA: C9H9O4 CHARGE: -1 INCHI: InChI=1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12) HEPATONET_1.0_ABBREVIATION: HC01519 EHMN_ABBREVIATION: C05582
is: CHEBI:545959
initial amount: NaN

metaM Asn X Ser Thr r
is: HMDB00051
has only substance units: false
is: SBO:0000247
is: CHEBI:28938
type: Species
notes: FORMULA: XH CHARGE: 0
boundary condition: false
name: protein-linked asparagine residue (N-glycosylation site)
constant: false
is: C01342
initial amount: NaN
initial concentration: 1.0

metaM 2ddecdicoa m
initial amount: NaN
boundary condition: false
is: HMDB11123
type: Species
initial concentration: 1.0
is: C05279
has only substance units: false
is: SBO:0000247
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
name: 2,6-dodecadienoylcoa
constant: false

metaR r0908
type: Reaction
kinetic law: MODEL1310110023#
is: SBO:0000185
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
reactant: MODEL1310110023#
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110023#

metaR FAOXC7C5m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C7-->C5)m
type: Reaction

metaR r2372
type: Reaction
reversible: true
product: MODEL1310110023#
kinetic law: MODEL1310110023#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_73682782_fb21_42c9_88a3_c51f5614253d
is encoded by: hsa:2629
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: GBA
has only substance units: false
type: Species
is: B7Z6S1
constant: false
initial amount: NaN

metaM HC02213 e
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
name: prostaglandin-e3
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:28031
type: Species
is: SBO:0000247

metaR r0651
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
reversible: true
fast: false
product: MODEL1310110023#
reactant: MODEL1310110023#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.2
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7

metaR r1608
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
is: SBO:0000185
product: MODEL1310110023#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR r0502
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
is: SBO:0000176
product: MODEL1310110023#
modifier: MODEL1310110023#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
reactant: MODEL1310110023#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.113
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_ffffeac1_8bb1_47fd_a8d1_44f57e0c7b9c
is: SBO:0000252
boundary condition: true
has only substance units: false
name: UCK2
is encoded by: hsa:7371
is: Q9BZX2
initial concentration: NaN
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_f35c56f7_f183_4927_a8a9_e2b99142e97d
name: PDE6H
initial amount: NaN
is: Q13956
type: Species
is encoded by: hsa:5149
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN

metaM 4hpro LT e
constant: false
has only substance units: false
is: HMDB00725
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
initial amount: NaN
boundary condition: false
name: trans-4-hydroxy-L-proline

metaR FBA4
is described by: ECO:0000269
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (226.2) or (229.1) or (226.3) or (230.1) or (226.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 4.1.2.13 Confidence Level: 4 AUTHORS: PMID:2996495,PMID:6284103,PMID:6298387 NOTES:NCD
product: MODEL1310110023#
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.2.13
reactant: MODEL1310110023#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110023#

metaM chol c
boundary condition: false
is: C00114
is: CHEBI:15354
type: Species
is: HMDB00097
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: Choline
constant: false
initial amount: NaN

metaR SO4t4 2
is: SBO:0000185
modifier: MODEL1310110023#
reactant: MODEL1310110023#
name: sulfate transport via sodium symport
fast: false
is described by: ECO:0000269
type: Reaction
product: MODEL1310110023#
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110023#_34034b6f_eb56_43eb_b95c_4e1a669dbb9d
initial amount: NaN
constant: false
name: GCH1
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2643
is: Q8IZH9
has only substance units: false
boundary condition: true
type: Species

metaR FAOXC122C101m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:2-->C10:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_555cd6bf_117b_4f0a_90cc_a510e85102b2
is encoded by: hsa:8733
name: GPAA1
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
is: O43292
constant: false
initial concentration: NaN

metaR 4NPHSFte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9344226 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Biochemical, Rat
kinetic law: MODEL1310110023#
type: Reaction
fast: false
reversible: true
name: xenobiotic transport
product: MODEL1310110023#
reactant: MODEL1310110023#
is: SBO:0000185
is described by: ECO:0000000

metaR OAGD3tg
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
name: oagd3 hs intracellular transport
reversible: true
reactant: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
product: MODEL1310110023#
kinetic law: MODEL1310110023#

metaR BHBtm
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
reversible: true
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
is described by: ECO:0000000
product: MODEL1310110023#
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_94242c66_85f7_465d_8fa1_8d45e717343e
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: CLYBL
has only substance units: false
constant: false
is encoded by: hsa:171425

metaM prostge2 c
name: prostaglandin E2(1-)
is: CHEBI:606564
has only substance units: false
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB01220

metaR r0196
reversible: true
modifier: MODEL1310110023#
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.6.1.5
reactant: MODEL1310110023#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
fast: false
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
kinetic law: MODEL1310110023#

metaM C02528 c
boundary condition: false
name: chenodeoxycholate
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB00518
has only substance units: false
is: CHEBI:36234
constant: false
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528

http://identifiers.org/biomodels.db/MODEL1310110023#_285d7fcc_822b_4710_95e1_36cb896cc3c7
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8396
is: P78356
name: PIP4K2B
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_026b56b9_13c0_447b_a0f8_ac207e09d0dd
initial amount: NaN
is: SBO:0000252
type: Species
is: O75912
boundary condition: true
is encoded by: hsa:9162
constant: false
name: DGKI
has only substance units: false
initial concentration: NaN

metaM oh1 c
constant: false
is: C01328
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
is: HMDB01039
is: SBO:0000247
notes: FORMULA: HO CHARGE: -1
name: hydroxide ion
initial concentration: 1.0

metaM nh4 e
is: CHEBI:28938
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial concentration: 1.0
is: HMDB00051
name: ammonium
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_dde0e986_7496_4a23_9e56_8fe05638b1bd
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:2523
boundary condition: true
has only substance units: false
is: Q6IZA2
initial amount: NaN
name: FUT1

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

metaR DOLP Uter
fast: false
is: SBO:0000176
product: MODEL1310110023#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
reversible: false
type: Reaction
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
name: dolichol phosphate flippase (uterus)

metaR r0504
type: Reaction
product: MODEL1310110023#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.3.10
is: SBO:0000176
kinetic law: MODEL1310110023#
is described by: ECO:0000000
reactant: MODEL1310110023#
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
fast: false
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:

metaR r1602
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110023#
is described by: ECO:0000000
fast: false
is: SBO:0000185
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#

metaR r2435
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
type: Reaction
reversible: false
reactant: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110023#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
kinetic law: MODEL1310110023#

metaR ATP2ter
name: AMP/ATP transporter, endoplasmic reticulum
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
type: Reaction
product: MODEL1310110023#
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_aa47218e_e8ca_4599_89e2_b5c291aaba0c
initial concentration: NaN
type: Species
constant: false
name: PYCR1
initial amount: NaN
boundary condition: true
is encoded by: hsa:5831
is: SBO:0000252
is: A6NFM2
has only substance units: false

metaM 4hpro LT c
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
is: CHEBI:18095
initial amount: NaN
name: trans-4-hydroxy-L-proline
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00725
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_41305b1a_c378_4d56_84c4_5c5e715f7c0b
type: Species
is: Q308M7
initial amount: NaN
name: ENPP3
initial concentration: NaN
is encoded by: hsa:5169
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110023#_13ef5f25_3025_4fad_acfc_85d70e1b0b6e
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
name: EHHADH
has only substance units: false
constant: false
is: Q9NY65
boundary condition: true
is encoded by: hsa:1962

metaR FMNALKPle
kinetic law: MODEL1310110023#
fast: false
type: Reaction
is described by: ECO:0000134
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110023#
name: FMNALKPle
reactant: MODEL1310110023#
reversible: false

metaM pram c
type: Species
is: CHEBI:58681
boundary condition: false
constant: false
is: C03090
is: HMDB01128
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H11NO7P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01053 EHMN_ABBREVIATION: C03090
name: 5-Phospho-beta-D-ribosylamine
initial amount: NaN

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

metaR PROSTGE1t
fast: false
type: Reaction
reversible: true
is described by: ECO:0000269
name: prostaglandin transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
kinetic law: MODEL1310110023#
product: MODEL1310110023#
is: SBO:0000185
reactant: MODEL1310110023#
modifier: MODEL1310110023#

metaR r1603
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000000
fast: false
product: MODEL1310110023#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

metaR O2Stm
is: SBO:0000185
product: MODEL1310110023#
kinetic law: MODEL1310110023#
fast: false
name: superoxide anion transport via diffusion (mitochondria)
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
type: Reaction

metaM CE2420 m
has only substance units: false
is: HMDB11123
type: Species
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
is: CHEBI:28387
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110023#_5261cfe0_27b0_4fc9_8127_d90edeec6347
initial amount: NaN
is encoded by: hsa:1854
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: P33316
name: DUT
type: Species
constant: false

metaM chol e
is: C00114
initial concentration: 1.0
is: HMDB00097
has only substance units: false
is: CHEBI:15354
name: Choline
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
constant: false

metaM pnto R e
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
boundary condition: false
is: HMDB00210
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:7916
name: (R)-Pantothenate
type: Species

metaM prostge2 e
is: HMDB01220
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:606564
constant: false
is: SBO:0000247
type: Species
name: prostaglandin E2(1-)
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584

metaM oh1 e
notes: FORMULA: HO CHARGE: -1
initial concentration: 1.0
initial amount: NaN
name: hydroxide ion
type: Species
boundary condition: false
is: HMDB01039
is: SBO:0000247
constant: false
has only substance units: false
is: C01328

metaR MANt4
kinetic law: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
modifier: MODEL1310110023#
name: D-mannose transport via sodium cotransport
is: SBO:0000185
reactant: MODEL1310110023#
product: MODEL1310110023#
type: Reaction
reversible: true
is described by: ECO:0000269

metaR FAOXC142C122m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)m
type: Reaction

metaM octa e
is: SBO:0000247
is: C06423
is: HMDB00482
notes: FORMULA: C8H15O2 CHARGE: -1
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:25646
has only substance units: false
boundary condition: false
initial amount: NaN
name: octanoate (n-C8:0)

metaM nh4 c
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
constant: false
is: CHEBI:28938
name: Ammonium
type: Species
is: C01342
has only substance units: false
initial concentration: 1.0
is: HMDB00051
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaR O2Stn
type: Reaction
kinetic law: MODEL1310110023#
name: superoxide anion transport via diffusion (nucleus)
reactant: MODEL1310110023#
reversible: true
fast: false
product: MODEL1310110023#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:

metaR r1604
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110023#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM T4hcinnm m
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:12876
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C9H7O3 CHARGE: -1 INCHI: InChI=1S/C9H8O3/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6,10H,(H,11,12)/p-1/b6-3+ EHMN_ABBREVIATION: C00811
has only substance units: false
name: trans-4-coumarate
is: HMDB02035

metaR RE2625C
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
type: Reaction
name: RE2625
product: MODEL1310110023#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:

metaR ARACHDtr
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110023#
name: intracellular transport
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#

metaM dpcoa m
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB01373
name: 3'-dephospho-CoA(2-)
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
is: CHEBI:57328

metaM Asn X Ser Thr l
initial amount: NaN
is: CHEBI:28938
boundary condition: false
initial concentration: 1.0
name: protein-linked asparagine residue (N-glycosylation site)
has only substance units: false
is: HMDB00051
constant: false
is: SBO:0000247
notes: FORMULA: XH CHARGE: 0
type: Species
is: C01342

http://identifiers.org/biomodels.db/MODEL1310110023#_e4e97072_9318_451a_bc80_21e30cff673e
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:2571
constant: false
name: GAD1
has only substance units: false
is: Q8IVA8
type: Species
initial concentration: NaN

metaR XYLt
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
reversible: true
is: SBO:0000185
reactant: MODEL1310110023#
name: D-xylose reversible transport
product: MODEL1310110023#
is described by: ECO:0000269
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
type: Reaction
fast: false

metaR r0614
is: SBO:0000176
product: MODEL1310110023#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
type: Reaction
fast: false
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36

metaR KHK
reactant: MODEL1310110023#
modifier: MODEL1310110023#
type: Reaction
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.1.3
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.3 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
fast: false
product: MODEL1310110023#
name: ketohexokinase
is: SBO:0000176

metaR H2Otp
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110023#
is: SBO:0000185
reactant: MODEL1310110023#
reversible: true
fast: false
name: H2O transport, peroxisomal
type: Reaction
is described by: ECO:0000000

metaR GALASE13ly
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110023#
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110023#
reversible: false
fast: false
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.2.1.23

metaR r2141
type: Reaction
is: SBO:0000185
modifier: MODEL1310110023#
fast: false
kinetic law: MODEL1310110023#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000000

metaM ttdca c
has only substance units: false
is: SBO:0000247
is: HMDB00806
type: Species
is: CHEBI:30807
notes: FORMULA: C14H27O2 CHARGE: -1 INCHI: InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)/p-1 EHMN_ABBREVIATION: C06424
constant: false
initial amount: NaN
boundary condition: false
name: myristate
initial concentration: 1.0

metaR UAGALDP
type: Reaction
is: SBO:0000176
reversible: false
product: MODEL1310110023#
kinetic law: MODEL1310110023#
fast: false
name: UDP-N-acetylgalactosamine diphosphorylase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110023#

metaR FAEL205
modifier: MODEL1310110023#
fast: false
reactant: MODEL1310110023#
name: fatty-acyl-CoA elongation (n-C20:5CoA)
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
type: Reaction
product: MODEL1310110023#
reversible: false
is: SBO:0000176
is described by: ECO:0000000

metaR S3TASE3ly
product: MODEL1310110023#
reversible: true
is: SBO:0000176
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 2 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110023#
name: N-acetylglucosamine-3-sulfatase, lysosomal

metaM 2ddecdicoa x
name: 2,6-dodecadienoylcoa
constant: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
is: C05279
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB11123
type: Species

metaM cyan c
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB02084
is: CHEBI:18407
name: hydrogen cyanide
is: SBO:0000247
initial amount: NaN
constant: false

metaR RE1573M
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/5.3.3.8
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
product: MODEL1310110023#
name: RE1573
is: SBO:0000176
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_b80acb7a_422d_40d2_ba8b_9623292a3ab1
is encoded by: hsa:1629
type: Species
initial concentration: NaN
is: P11182
is: SBO:0000252
has only substance units: false
boundary condition: true
name: DBT
constant: false
initial amount: NaN

metaM octa c
is: CHEBI:25646
is: HMDB00482
has only substance units: false
name: octanoate (n-C8:0)
initial amount: NaN
notes: FORMULA: C8H15O2 CHARGE: -1
boundary condition: false
initial concentration: 1.0
is: C06423
constant: false
type: Species
is: SBO:0000247

metaM xan c
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
initial amount: NaN
boundary condition: false
is: C00385
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
is: HMDB00292
is: CHEBI:17712
has only substance units: false
name: Xanthine

http://identifiers.org/biomodels.db/MODEL1310110023#_ef20b9e5_9b94_4247_9505_cfc89c9eab73
name: PRDX2
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:7001

http://identifiers.org/biomodels.db/MODEL1310110023#_2f5a8829_9b95_4263_963b_b66fda903450
has only substance units: false
type: Species
name: PPA1
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:5464
boundary condition: true
initial amount: NaN
is: Q15181

metaR DM Asn X Ser Thr ly
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Asn-X-Ser/Thr(ly)
type: Reaction

metaR FAEL204
kinetic law: MODEL1310110023#
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110023#
name: fatty-acyl-CoA elongation (n-C20:4CoA)
reversible: false
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
fast: false
type: Reaction
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_b6cf0ea7_5296_422d_8521_73de8f62d206
name: ALDH2
boundary condition: true
is encoded by: hsa:217
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
is: P05091
constant: false

metaR r2140
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110023#
reactant: MODEL1310110023#
product: MODEL1310110023#
kinetic law: MODEL1310110023#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction

metaR MCLACCYSR
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:6945862 NOTES:MM
reactant: MODEL1310110023#
fast: false
name: 3-mercaptolactate:cysteine reductase
is described by: ECO:0000000
product: MODEL1310110023#
kinetic law: MODEL1310110023#
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110023#_63aff450_cf32_47af_b090_2f6a53bc97aa
boundary condition: true
has only substance units: false
name: _AI222095_1_e
is: SBO:0000252
is encoded by: hsa:AI222095
constant: false
initial amount: NaN
type: Species
initial concentration: NaN

metaR SERCYSNaEx
modifier: MODEL1310110023#
is described by: ECO:0000269
product: MODEL1310110023#
fast: false
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
name: L-serine/L-cysteine Na-dependent exchange (Ser-L in)
type: Reaction
reactant: MODEL1310110023#
reversible: false

metaM malttr e
has only substance units: false
initial concentration: 1.0
name: maltotriose
is: CHEBI:27931
initial amount: NaN
type: Species
boundary condition: false
is: C01835
is: HMDB01262
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_5edbfe37_1488_4c93_8341_e848bb7d0b7e
constant: false
boundary condition: true
is: O94903
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:11212
has only substance units: false
name: PROSC

metaR r0616
is described by: ECO:0000000
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
reversible: true
reactant: MODEL1310110023#
type: Reaction
kinetic law: MODEL1310110023#
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
fast: false
modifier: MODEL1310110023#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110023#_b38bcdcf_91ef_4e19_ad4b_105289f07953
is: SBO:0000252
constant: false
type: Species
is: P09960
name: LTA4H
is encoded by: hsa:4048
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN

metaM m8masn g
is: SBO:0000247
has only substance units: false
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
notes: FORMULA: C70H117N2O55X CHARGE: 0
boundary condition: false
type: Species
initial concentration: 1.0
is: C05876
initial amount: NaN
constant: false

metaM dolmanp U r
initial concentration: 1.0
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
is: CHEBI:15809
boundary condition: false
name: Dolichyl phosphate D-mannose, human uterine homolog

metaM ttdca e
is: HMDB00806
is: CHEBI:30807
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C14H27O2 CHARGE: -1 EHMN_ABBREVIATION: C06424
is: C06424
type: Species
constant: false
name: tetradecanoate (n-C14:0)
has only substance units: false
initial concentration: 1.0

metaR FBA2
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/4.1.2.13
type: Reaction
reversible: true
is described by: ECO:0000304
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
product: MODEL1310110023#
reactant: MODEL1310110023#
is: SBO:0000176
fast: false
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (229.1) or (230.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.1.2.13 Confidence Level: 2 AUTHORS: NOTES:NCD

metaM for r
name: Formate
constant: false
boundary condition: false
is: HMDB00142
initial amount: NaN
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
has only substance units: false
is: CHEBI:15740
initial concentration: 1.0
is: SBO:0000247
type: Species
is: C00058

metaR SERGLNexR
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110023#
is: SBO:0000185
product: MODEL1310110023#
modifier: MODEL1310110023#
is described by: ECO:0000304
type: Reaction
name: L-Serine/Glutamine reversible exchange
fast: false
reactant: MODEL1310110023#
reversible: true

metaM 3mop c
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB00491
constant: false
name: 3-methyl-2-oxopentanoate
is: CHEBI:28654
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671

metaR r1600
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110023#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110023#
reactant: MODEL1310110023#

metaR r0615
modifier: MODEL1310110023#
reactant: MODEL1310110023#
is: SBO:0000176
kinetic law: MODEL1310110023#
is described by: ECO:0000000
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.168
notes: GENE_ASSOCIATION: (1629.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
reversible: true
type: Reaction
product: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_16537e47_04de_4e7f_92c5_fbc0f81379f7
boundary condition: true
initial amount: NaN
name: SLC35D2
has only substance units: false
is: SBO:0000252
is: Q76EJ3
constant: false
type: Species
is encoded by: hsa:11046
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_98ad89ff_cc66_411a_ae2c_5aa5d912e71a
is encoded by: hsa:205
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
constant: false
name: AK4
is: SBO:0000252

metaR r2142
reactant: MODEL1310110023#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
kinetic law: MODEL1310110023#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110023#
product: MODEL1310110023#

metaM adrncoa c
type: Species
constant: false
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
is: http://identifiers.org/pubchem.compound/47205480
is: C16170
name: adrenyl coenzyme A
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN

metaR ARACHt
reactant: MODEL1310110023#
type: Reaction
fast: false
product: MODEL1310110023#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110023#
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110023#_10c36787_917b_4b7e_826b_414e2a6c4ef4
is: Q86YU0
type: Species
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
name: CA7
is: SBO:0000252
is encoded by: hsa:766
initial concentration: NaN

metaM mmcoa R m
is: HMDB01269
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721
is: CHEBI:57326
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
name: (R)-methylmalonyl-CoA(5-)
initial concentration: 1.0
boundary condition: false

metaM Rtotal3 e
is: CHEBI:3554
initial amount: NaN
notes: FORMULA: CO2FULLR3 CHARGE: -1
initial concentration: 1.0
has only substance units: false
type: Species
name: R total 3 position
boundary condition: false
is: SBO:0000247
is: C00255
constant: false
is: HMDB00244

http://identifiers.org/biomodels.db/MODEL1310110023#_0027873b_516f_490d_b8c1_46628d546dc6
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
name: PIGC
has only substance units: false
is encoded by: hsa:5279

metaM dec24dicoa x
initial amount: NaN
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
constant: false
is: SBO:0000247
is: HMDB01168
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
name: 2,4-decadienoylcoa

http://identifiers.org/biomodels.db/MODEL1310110023#_95adad59_70ce_4307_bb3f_be9e3b82359d
is encoded by: hsa:55902
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
name: ACSS2
is: Q5QPH3

metaM ksii core2 deg3 l
type: Species
boundary condition: false
name: keratan sulfate II (core 2-linked), degradation product 3
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C58H94N5O46S2X CHARGE: -2
is: HMDB00143
is: CHEBI:12936

metaM na1 c
initial concentration: 1.0
is: CHEBI:4541
name: Sodium
has only substance units: false
constant: false
type: Species
is: SBO:0000247
boundary condition: false
is: C01330
is: HMDB00588
initial amount: NaN
notes: FORMULA: Na CHARGE: 1

metaM acgalfucgalacglcgalgluside hs g
initial amount: NaN
has only substance units: false
is: HMDB00304
is: CHEBI:57847
type: Species
notes: FORMULA: C58H102N3O31FULLRCO CHARGE: 0
initial concentration: 1.0
name: Type IA glycolipid
boundary condition: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_b7307e7b_8ddf_4b4b_8bf8_08afd4d2e2f0
is encoded by: hsa:761
is: SBO:0000252
type: Species
has only substance units: false
is: P07451
initial amount: NaN
constant: false
name: CA3
initial concentration: NaN
boundary condition: true

metaR HMGCOASim
reversible: false
type: Reaction
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
is: SBO:0000176
fast: false
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.3.3.10
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
name: Hydroxymethylglutaryl CoA synthase (ir)
product: MODEL1310110023#
is described by: ECO:0000269

metaR CMPSAS
product: MODEL1310110023#
kinetic law: MODEL1310110023#
is described by: ECO:0000304
name: CMP sialic acid synthase
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.7.43
type: Reaction
reactant: MODEL1310110023#
is: SBO:0000176
modifier: MODEL1310110023#
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_ea8c5e65_c3f8_4fe7_972c_ec193c256fea
is encoded by: hsa:6482
boundary condition: true
initial amount: NaN
name: ST3GAL1
type: Species
has only substance units: false
constant: false
is: Q11201
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110023#_91640867_3c15_453e_bd02_104961913ae4
boundary condition: true
constant: false
is encoded by: hsa:9058
is: SBO:0000252
name: SLC13A2
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: E7ETH5
type: Species

metaR CYTK6n
modifier: MODEL1310110023#
fast: false
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110023#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110023#
name: cytidylate kinase (CMP,CTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR PGMT
is version of: http://identifiers.org/ec-code/5.4.2.2
reversible: true
modifier: MODEL1310110023#
type: Reaction
kinetic law: MODEL1310110023#
is: SBO:0000176
fast: false
name: phosphoglucomutase
reactant: MODEL1310110023#
is described by: ECO:0000134
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (5236.1) or (55276.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.4.2.2 Confidence Level: 0 AUTHORS: PMID:4829444 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110023#_f5ca3a79_f81c_472a_a5e9_cfff7229e0ed
initial concentration: NaN
is encoded by: hsa:3037
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: HAS2
is: Q92819
constant: false
has only substance units: false

metaR S6T11g
type: Reaction
modifier: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110023#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

metaR O2Stx
product: MODEL1310110023#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
name: superoxide anion transport via diffusion (peroxisome)
is described by: ECO:0000000
type: Reaction
reversible: true
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#

metaR NDPK10
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
kinetic law: MODEL1310110023#
name: nucleoside-diphosphate kinase (ATP:dIDP)
type: Reaction
reactant: MODEL1310110023#
fast: false
product: MODEL1310110023#
modifier: MODEL1310110023#

metaM nh4 m
constant: false
is: C01342
initial concentration: 1.0
is: CHEBI:28938
initial amount: NaN
type: Species
is: SBO:0000247
name: Ammonium
boundary condition: false
has only substance units: false
is: HMDB00051
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342

metaR AMETt2m
fast: false
product: MODEL1310110023#
name: S-Adenosyl-L-methionine reversible transport, mitochondrial
reversible: true
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
modifier: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: (115286.3) or (115286.2) or (115286.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14674884 NOTES:Added by RS/TV (6/17/05)

metaM fad m
boundary condition: false
is: C00016
is: CHEBI:16238
name: Flavin adenine dinucleotide oxidized
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB01248
initial amount: NaN
has only substance units: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016

metaM odecoa c
is: CHEBI:3793
is: HMDB01322
constant: false
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
name: Octadecenoyl-CoA (n-C18:1CoA)
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_87db2aa1_e35c_4de3_ad76_571cd471582c
initial amount: NaN
is: SBO:0000252
name: FUT8
is: Q546E0
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is encoded by: hsa:2530

metaM 3dsphgn c
initial amount: NaN
type: Species
has only substance units: false
name: (2S)-1-hydroxy-3-oxooctadecan-2-aminium
is: HMDB01480
boundary condition: false
is: SBO:0000247
is: CHEBI:58299
initial concentration: 1.0
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17,20H,2-16,19H2,1H3/p+1/t17-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01019 EHMN_ABBREVIATION: C02934
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_d21a3a41_ae68_424d_bdc5_e6c9ebda24c4
constant: false
is encoded by: hsa:4598
type: Species
boundary condition: true
is: SBO:0000252
name: MVK
is: B2RDU6
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaM core4 g
constant: false
name: Core 4
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C24H40N3O15X CHARGE: 0
is: CHEBI:16478
initial amount: NaN

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

metaR EX tcynt LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

metaM na1 e
type: Species
is: CHEBI:4541
is: HMDB00588
notes: FORMULA: Na CHARGE: 1
initial concentration: 1.0
boundary condition: false
is: C01330
name: Sodium
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110023#_d6555fa7_2608_434e_953b_e4d709840566
has only substance units: false
is encoded by: hsa:83549
name: UCK1
is: SBO:0000252
initial amount: NaN
is: Q5JT09
constant: false
boundary condition: true
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_7a392496_be40_405a_9149_9cef49034cb2
has only substance units: false
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:5153
is: Q7Z364
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: PDE1B

metaR GAMt1r
kinetic law: MODEL1310110023#
name: glucosamine transport (uniport)
product: MODEL1310110023#
is: SBO:0000185
fast: false
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (6513.1) or (6517.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_5921532a_52e4_4fa8_8d8c_d22939eed5e5
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: CMAS
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:55907
is: Q8NFW8
type: Species

metaR H2Otn
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110023#
reactant: MODEL1310110023#
name: H2O transport, nuclear
reversible: true
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000

metaM xoltriol c
initial amount: NaN
has only substance units: false
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
is: HMDB01457
is: SBO:0000247
is: CHEBI:16496
boundary condition: false
constant: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_7c458bc2_9df5_4686_9435_5aa2eadaedbe
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6647
is: P00441
initial concentration: NaN
name: SOD1
boundary condition: true
constant: false
type: Species

metaM gacpail hs r
initial amount: NaN
is: C00092
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:61548
constant: false
type: Species
initial concentration: 1.0
is: HMDB01401
name: glucosaminyl-acylphosphatidylinositol
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0

metaR r1717
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110023#
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reversible: false
is: SBO:0000185
type: Reaction
fast: false
name: Y+LAT2 Utilized transport

metaM 4hpro LT m
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB00725
has only substance units: false
name: trans-4-hydroxy-L-proline
is: CHEBI:18095
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_7bd62dcd_4071_406c_9145_ccbb6d33528b
type: Species
has only substance units: false
name: PIGA
constant: false
initial amount: NaN
is encoded by: hsa:5277
is: B3KUV7
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaM ksi deg33 l
has only substance units: false
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
name: keratan sulfate I, degradation product 33
is: CHEBI:12936
boundary condition: false
initial amount: NaN
is: HMDB00143
notes: FORMULA: C76H125N5O62S2 CHARGE: -2

metaM 2mbcoa m
is: SBO:0000247
has only substance units: false
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
is: CHEBI:57336
boundary condition: false
is: HMDB01041
initial amount: NaN
name: 2-methylbutanoyl-CoA(4-)
constant: false
type: Species
initial concentration: 1.0

metaM ile L m
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB00172
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
type: Species
name: L-isoleucine
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:17191

http://identifiers.org/biomodels.db/MODEL1310110023#_20d8dcbe_939e_4ad1_8c90_2af249fbc4a6
initial amount: NaN
name: ATP2B1
boundary condition: true
is encoded by: hsa:490
type: Species
has only substance units: false
is: SBO:0000252
is: P20020
initial concentration: NaN
constant: false

metaR PHYTt
name: fatty acid transport via diffusion
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110023#
fast: false
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ

metaR H2Otm
type: Reaction
modifier: MODEL1310110023#
reactant: MODEL1310110023#
is: SBO:0000185
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
fast: false
name: H2O transport, mitochondrial
is described by: ECO:0000269
kinetic law: MODEL1310110023#
reversible: true
product: MODEL1310110023#

metaR VACCt
reactant: MODEL1310110023#
product: MODEL1310110023#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
kinetic law: MODEL1310110023#
is: SBO:0000185
name: fatty acid transport via diffusion
type: Reaction

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_a626b63a_036d_4107_9170_9c6ebe0f03a1
type: Species
is: P04746
name: AMY2A
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:279
initial amount: NaN
boundary condition: true
has only substance units: false

metaM ile L e
is: CHEBI:17191
boundary condition: false
initial amount: NaN
constant: false
is: HMDB00172
type: Species
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: SBO:0000247
has only substance units: false
name: L-isoleucine
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110023#_f922ba07_3bea_4552_be2c_39c2d2fd69ed
has only substance units: false
type: Species
constant: false
boundary condition: true
is: SBO:0000297
is encoded by: hsa:126
initial amount: NaN
name: ADH1B:ADH1C
initial concentration: NaN
has part: P00326

http://identifiers.org/biomodels.db/MODEL1310110023#_2b6817ab_222e_4023_b2ac_f73f242c819f
boundary condition: true
name: ALPPL2
type: Species
initial concentration: NaN
is: P10696
is encoded by: hsa:251
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR C4CRNe
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of butyryl carnitine into the extra cellular space
type: Reaction

metaR GLYt2r
reactant: MODEL1310110023#
product: MODEL1310110023#
is described by: ECO:0000304
is: SBO:0000185
type: Reaction
modifier: MODEL1310110023#
reversible: true
name: glycine reversible transport via proton symport
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
fast: false
kinetic law: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_fc6e6c44_fba3_48d3_839a_9df3ce836575
constant: false
name: PECR
is encoded by: hsa:55825
is: Q9BY49
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252

metaR r2122
modifier: MODEL1310110023#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110023#
is described by: ECO:0000000
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110023#

metaM pristcoa c
initial amount: NaN
is: CHEBI:51341
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
name: pristanoyl coa
constant: false

metaM CE5162 r
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:57923
type: Species
initial amount: NaN
name: trans,cis-2,9-octadecadienoyl-CoA
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,18-19,26-28,32-34,38,49-50H,4-10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5162

metaR r0085
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
type: Reaction
reversible: false
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.1.1.42
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
product: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110023#
fast: false
kinetic law: MODEL1310110023#

metaR HEX4
reactant: MODEL1310110023#
product: MODEL1310110023#
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.1.1
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (3098.2) or (2645.2) or (3098.3) or (2645.3) or (3098.4) or (3099.1) or (3098.5) or (3098.1) or (3101.1) or (80201.1) or (2645.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.7 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. also active in ecoli PMID: 4557975
is version of: http://identifiers.org/ec-code/2.7.1.2
name: hexokinase (D-mannose:ATP)
fast: false
reversible: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110023#

metaR GALtly
is: SBO:0000185
product: MODEL1310110023#
reversible: false
name: galactose efflux from lysosome
kinetic law: MODEL1310110023#
is described by: ECO:0000000
reactant: MODEL1310110023#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110023#_49433b1a_5124_431c_912a_a23e9792a3bb
is encoded by: hsa:594
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: BCKDHB
is: Q9BQL0
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_193f441f_4a63_421d_95df_ec6bc9534049
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:T83654
name: _T83654_1_e
type: Species
boundary condition: true
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110023#_dd31ba30_dfc6_4967_9057_c979cbca3391
is encoded by: hsa:39
constant: false
name: ACAT2
type: Species
is: Q9BWD1
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaM 3hibutcoa m
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:28259
is: HMDB01052
has only substance units: false
name: (S)-3-Hydroxyisobutyryl-CoA
boundary condition: false
constant: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
is: SBO:0000247

metaR r2123
reactant: MODEL1310110023#
type: Reaction
kinetic law: MODEL1310110023#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110023#
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000185
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110023#_11f193c9_f674_4e66_b442_d59bc3fd5337
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4701
type: Species
name: NDUFA7
is: Q6FG42
has only substance units: false
is: SBO:0000252
constant: false

metaM tmndnccoa m
constant: false
name: timnodonyl coenzyme A
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB06514
boundary condition: false
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
has only substance units: false

metaR r0086
modifier: MODEL1310110023#
reversible: false
product: MODEL1310110023#
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.3
fast: false
is described by: ECO:0000000
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
kinetic law: MODEL1310110023#
is: SBO:0000176
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_1cf23629_6c60_442e_a956_eca0c486c895
constant: false
boundary condition: true
name: ALG12
is: SBO:0000252
is: Q9BV10
is encoded by: hsa:79087
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_df336afa_3c4c_43d7_b304_c86319d02cf1
has only substance units: false
initial amount: NaN
is encoded by: hsa:AI934540
constant: false
name: _AI934540_1_c
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN

metaR FALDH
type: Reaction
product: MODEL1310110023#
fast: false
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
reversible: true
name: formaldehyde dehydrogenase
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.1.1.1
modifier: MODEL1310110023#

metaM gthrd c
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: CHEBI:57925
initial amount: NaN
type: Species
is: HMDB00125
name: Reduced glutathione
constant: false
boundary condition: false
is: SBO:0000247
is: C00051
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_e1f4655a_1c52_417d_adb4_c51ba2b7bea3
initial amount: NaN
is encoded by: hsa:492
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
constant: false
is: Q16720
boundary condition: true
name: ATP2B3

metaM 3mop e
is: CHEBI:28654
initial amount: NaN
is: HMDB00491
boundary condition: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
has only substance units: false
constant: false
is: SBO:0000247
type: Species
name: 3-methyl-2-oxopentanoate
initial concentration: 1.0

metaR r0617
type: Reaction
is: SBO:0000176
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110023#
product: MODEL1310110023#
kinetic law: MODEL1310110023#
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110023#_c8c5ea77_6663_46f9_a62c_bb46cfc488b9
constant: false
name: PRPS1L1
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:221823
is: SBO:0000252
initial amount: NaN

metaR ALAGLNNaEx
kinetic law: MODEL1310110023#
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
reactant: MODEL1310110023#
modifier: MODEL1310110023#
product: MODEL1310110023#
reversible: false
name: L-alanine/L-glutamine Na-dependent exchange (Ala-L in)

metaR PPCDC
name: phosphopantothenoylcysteine decarboxylase
is: SBO:0000176
type: Reaction
reactant: MODEL1310110023#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 4 AUTHORS: PMID:11923312 NOTES:
reversible: false
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/4.1.1.36
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_f03a9c3e_1937_46a6_a41b_c0823da231f4
type: Species
boundary condition: true
is encoded by: hsa:2181
constant: false
initial concentration: NaN
initial amount: NaN
is: O95573
name: ACSL3
has only substance units: false
is: SBO:0000252

metaM c4crn c
is: http://identifiers.org/pubchem.compound/213144
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: butyryl carnitine
is: HMDB02013
constant: false
boundary condition: false
type: Species
notes: FORMULA: C11H21NO4 CHARGE: 0
is: C02862

metaM gdp g
name: GDP(3-)
is: SBO:0000247
has only substance units: false
is: CHEBI:58189
type: Species
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: HMDB01201
initial concentration: 1.0

metaR APOCFm
name: Apocarboxylase formation, mitochondrial
fast: false
kinetic law: MODEL1310110023#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:IT faked reaction to balance reaction in human biotin metabolism
type: Reaction
product: MODEL1310110023#
reactant: MODEL1310110023#

metaR r2120
kinetic law: MODEL1310110023#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110023#
is described by: ECO:0000000
reversible: true
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110023#
modifier: MODEL1310110023#

metaR S6T7g
fast: false
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
reactant: MODEL1310110023#
is described by: ECO:0000000
reversible: false
product: MODEL1310110023#

metaR r0083
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110023#
is described by: ECO:0000000
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
product: MODEL1310110023#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.42
modifier: MODEL1310110023#

metaR CLFORtex
product: MODEL1310110023#
reactant: MODEL1310110023#
modifier: MODEL1310110023#
is described by: ECO:0000304
kinetic law: MODEL1310110023#
is: SBO:0000185
notes: GENE_ASSOCIATION: (5172.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
fast: false
type: Reaction
name: chloride transport via formate countertransport
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110023#_750fe0ad_8127_41a7_be5c_12b3b7d61d0c
is: SBO:0000252
is: Q9Y2Q0
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:10396
boundary condition: true
initial amount: NaN
name: ATP8A1
has only substance units: false

metaR ST8SIA11
reactant: MODEL1310110023#
reversible: false
product: MODEL1310110023#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.99.8
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
is: SBO:0000176
fast: false
name: Beta-galactoside alpha-2,3-sialyltransferase
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
type: Reaction

metaR GPIMTer U
fast: false
is: SBO:0000176
is described by: ECO:0000000
name: GlcN-acylPI mannosyltransferase, endoplasmic reticulum
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
reversible: false
type: Reaction
modifier: MODEL1310110023#
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (93183.1) and (54965.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11226175,PMID:15635094 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110023#_4c9d5216_57c0_4b78_ba71_e2d628365e76
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:6391
is: SBO:0000252
name: SDHC
is: Q99643
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR r2334
kinetic law: MODEL1310110023#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110023#
reactant: MODEL1310110023#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction

metaM T antigen g
initial concentration: 1.0
name: T antigen (core 1)
constant: false
notes: FORMULA: C14H24NO10X CHARGE: 0
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:22783
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_2038896c_f60d_43a4_98b1_e6800cc5cdb6
is encoded by: hsa:1607
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: Q9Y6T7
initial amount: NaN
name: DGKB
type: Species

metaR Asn X Ser Thrtr
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110023#
name: Asn-X-Ser/Thr transport (from ER to lysosome)
type: Reaction
product: MODEL1310110023#
fast: false
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:10823827,PMID:12845534 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110023#_7cbebd80_9589_4f71_9d84_07c326d58715
is encoded by: hsa:2687
type: Species
has only substance units: false
constant: false
is: P36269
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: GGT5

http://identifiers.org/biomodels.db/MODEL1310110023#_f6b8a980_1fc7_4658_a5d1_b45ece81d4e2
is: E9KL44
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:3030
name: HADHA
initial concentration: NaN
boundary condition: true
type: Species

metaM ahcys r
has only substance units: false
is: SBO:0000247
is: CHEBI:16680
initial amount: NaN
notes: FORMULA: C14H20N6O5S CHARGE: 0 INCHI: InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
boundary condition: false
type: Species
name: S-adenosyl-L-homocysteine
is: HMDB00939
initial concentration: 1.0
constant: false

metaM g2m8mpdol U r
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: CHEBI:59093
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
notes: FORMULA: C1845H3040N20O720P20 CHARGE: -20

metaR r1895
reversible: false
modifier: MODEL1310110023#
product: MODEL1310110023#
fast: false
type: Reaction
reactant: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_669363a0_1150_4f6d_bcd4_bbc780347cd2
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AI824319
type: Species
has only substance units: false
name: _AI824319_1_r
is: SBO:0000252

metaR r2121
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
product: MODEL1310110023#
reversible: true
is: SBO:0000185

metaR HEX7
kinetic law: MODEL1310110023#
type: Reaction
reversible: false
fast: false
modifier: MODEL1310110023#
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (2645.2) or (2645.3) or (3098.3) or (3098.1) or (3101.1) or (3098.2) or (3099.1) or (2645.1) or (3098.4) or (80201.1) or (3098.5) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. Same as 2.7.1.4
is version of: http://identifiers.org/ec-code/2.7.1.2
is: SBO:0000176
name: hexokinase (D-fructose:ATP)
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.1.1
reactant: MODEL1310110023#

metaR r0084
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
reversible: true
reactant: MODEL1310110023#
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.1.1.42
type: Reaction
fast: false
kinetic law: MODEL1310110023#
is described by: ECO:0000000
modifier: MODEL1310110023#
is: SBO:0000176
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42

metaM hepcoa m
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C28H44N7O17P3S CHARGE: -4
name: heptanoylcoa
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB12969

http://identifiers.org/biomodels.db/MODEL1310110023#_5300a53c_7b07_43f3_83a3_36214afb3aa7
name: PIGX
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:54965
is: Q8TBF5
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR r2335
product: MODEL1310110023#
reactant: MODEL1310110023#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110023#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
is described by: ECO:0000000

metaM fe3 e
is: SBO:0000247
is: CHEBI:29034
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
name: Fe3+
is: HMDB12943
constant: false
notes: FORMULA: Fe CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC01847
has only substance units: false

metaR ST8SIA12
is described by: ECO:0000000
fast: false
name: Beta-galactoside alpha-2,3-sialyltransferase
modifier: MODEL1310110023#
is: SBO:0000176
reactant: MODEL1310110023#
reversible: false
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.4.99.8
type: Reaction
kinetic law: MODEL1310110023#

metaM tcynt e
is: SBO:0000247
initial amount: NaN
name: thiocyanate
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:18022
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
is: HMDB01453
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_20000c9e_df88_45cd_a08c_3aa51ce4d092
initial concentration: NaN
is: E9PAY8
boundary condition: true
constant: false
is encoded by: hsa:8612
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: PPAP2C

metaM gthrd e
is: CHEBI:57925
boundary condition: false
is: HMDB00125
type: Species
has only substance units: false
constant: false
initial amount: NaN
name: glutathionate(1-)
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: SBO:0000247
initial concentration: 1.0

metaR EX gam LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Glucosamine
type: Reaction

metaM gdp m
initial concentration: 1.0
has only substance units: false
is: HMDB01201
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: SBO:0000247
name: GDP
type: Species
boundary condition: false
constant: false
is: CHEBI:58189
initial amount: NaN
is: C00035

metaM HC01409 m
boundary condition: false
initial concentration: 1.0
name: Hexanoyl-CoA
is: SBO:0000247
notes: FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h14-16,20-22,26,37-38H,4-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05270
has only substance units: false
is: CHEBI:27540
type: Species
initial amount: NaN
constant: false

metaM c4crn e
name: butyryl carnitine
constant: false
notes: FORMULA: C11H21NO4 CHARGE: 0
is: HMDB02013
boundary condition: false
initial concentration: 1.0
is: C02862
is: http://identifiers.org/pubchem.compound/213144
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN

metaR r1599
reversible: true
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
product: MODEL1310110023#
reactant: MODEL1310110023#
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR HEX1
product: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.1
name: hexokinase (D-glucose:ATP)
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
modifier: MODEL1310110023#
is described by: ECO:0000134
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.2
is: SBO:0000176
fast: false

metaM 4izp c
is: HMDB01014
is: CHEBI:57255
boundary condition: false
type: Species
notes: FORMULA: C6H7N2O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01157 EHMN_ABBREVIATION: C03680
constant: false
has only substance units: false
name: 4-Imidazolone-5-propanoate
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaR r0940
product: MODEL1310110023#
name: Free diffusion
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110023#

metaM HC02202 c
constant: false
initial concentration: 1.0
name: prostaglandin A1(1-)
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
has only substance units: false
initial amount: NaN
is: CHEBI:57398
type: Species
is: SBO:0000247
boundary condition: false

metaM C05279 m
is: SBO:0000247
type: Species
name: trans,cis-Lauro-2,6-dienoyl-CoA
constant: false
boundary condition: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
is: HMDB11123
has only substance units: false
is: CHEBI:28387
initial concentration: 1.0
initial amount: NaN

metaR S3TASE2ly
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000
fast: false
product: MODEL1310110023#
reactant: MODEL1310110023#
name: N-acetylglucosamine-3-sulfatase, lysosomal
kinetic law: MODEL1310110023#
reversible: true
type: Reaction

metaR MTHFC
fast: false
modifier: MODEL1310110023#
reversible: true
notes: GENE_ASSOCIATION: (4522.1) or (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
is: SBO:0000176
reactant: MODEL1310110023#
product: MODEL1310110023#
kinetic law: MODEL1310110023#
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.5
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/3.5.4.9
name: methenyltetrahydrofolate cyclohydrolase

metaR r2126
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110023#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110023#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110023#
is: SBO:0000185
product: MODEL1310110023#
fast: false

metaR BILIRED
kinetic law: MODEL1310110023#
reversible: false
is described by: ECO:0000000
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (645.1) or (644.1) SUBSYSTEM: Heme degradation EC Number: 1.3.1.24 Confidence Level: 0 AUTHORS: PMID:12456881,PMID:7656592,PMID:8117274 NOTES:TDV
reactant: MODEL1310110023#
type: Reaction
modifier: MODEL1310110023#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.24
name: Nad(p)h biliverdin reductase

metaR r0081
modifier: MODEL1310110023#
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.12
type: Reaction
reactant: MODEL1310110023#
fast: false
product: MODEL1310110023#
is described by: ECO:0000000
name: L-Alanine:2-oxoglutarate aminotransferase Glutamate metabolism / Alanine and aspartate metabolism EC:2.6.1.2
is: SBO:0000176
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Citric acid cycle EC Number: 2.6.1.2 Confidence Level: 0 AUTHORS: PMID:15663181,PMID:2088925,PMID:454616 NOTES:

metaM sucsal m
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
has only substance units: false
initial concentration: 1.0
name: Succinic semialdehyde
constant: false
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:57706
is: SBO:0000247
is: HMDB01259

http://identifiers.org/biomodels.db/MODEL1310110023#_7c53fed5_3daa_45db_abad_7ec43709a8fc
is: SBO:0000252
is encoded by: hsa:U37519
has only substance units: false
type: Species
boundary condition: true
name: _U37519_1_m
constant: false
initial concentration: NaN
initial amount: NaN

metaR DMNONCRNCPT2
name: DMNONCRNCPT2
reversible: true
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
product: MODEL1310110023#
fast: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110023#_1a2326af_7774_430e_a1d5_7a88b4c9cdae
initial amount: NaN
is encoded by: hsa:23464
is: E2QC23
type: Species
initial concentration: NaN
constant: false
name: GCAT
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR DMATTx
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
reactant: MODEL1310110023#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.5.1.1
fast: false
product: MODEL1310110023#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
is described by: ECO:0000134
name: dimethylallyltranstransferase

metaR EX prgstrn LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Progesterone exchange
type: Reaction

metaR r2127
fast: false
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reactant: MODEL1310110023#
reversible: true
product: MODEL1310110023#

metaM tsul c
is: HMDB00257
constant: false
has only substance units: false
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
is: CHEBI:16094
initial concentration: 1.0
name: thiosulfate(2-)
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species

metaM gdp n
name: GDP(3-)
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
is: HMDB01201
initial amount: NaN
boundary condition: false
is: CHEBI:58189
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
has only substance units: false

metaM hom L e
initial amount: NaN
initial concentration: 1.0
type: Species
name: L-homoserine
is: SBO:0000247
is: CHEBI:15699
boundary condition: false
constant: false
is: HMDB00719
has only substance units: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239

http://identifiers.org/biomodels.db/MODEL1310110023#_032b4c0a_ef4c_441d_8f01_ebb5580ea3d7
name: ALDOA
is encoded by: hsa:226
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_8fefb54f_44ce_4b08_a947_3bb402599fb1
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:80724
name: ACAD10
is: G3XAJ0

metaR XOLDIOLONEt
is described by: ECO:0000000
kinetic law: MODEL1310110023#
type: Reaction
product: MODEL1310110023#
fast: false
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
name: lipid, flip-flop intracellular transport
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110023#_5bef7109_f531_4713_a761_340cc165ef7e
constant: false
has only substance units: false
name: PDE9A
type: Species
is encoded by: hsa:5152
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaR ACCOAgt
is: SBO:0000185
modifier: MODEL1310110023#
name: acetyl-coa transport
reactant: MODEL1310110023#
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12739170 NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ
fast: false
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110023#
reversible: true

metaR EX fe3 LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Fe3+ exchange
type: Reaction

metaM 1pyr5c m
is: HMDB01301
constant: false
initial concentration: 1.0
is: C03912
name: 1-Pyrroline-5-carboxylate
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:15893
boundary condition: false
initial amount: NaN

metaM gal1p c
is: CHEBI:58336
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3+,4+,5-,6-/m1/s1 EHMN_ABBREVIATION: C00446
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
name: (2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphate
is: HMDB00645

metaR r1598
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110023#
reversible: true
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110023#
is: SBO:0000185

metaR r0082
reactant: MODEL1310110023#
fast: false
modifier: MODEL1310110023#
type: Reaction
product: MODEL1310110023#
reversible: true
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
notes: GENE_ASSOCIATION: (2875.1) or (84706.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
kinetic law: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.2

metaM ascb L e
boundary condition: false
constant: false
type: Species
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
initial amount: NaN
is: SBO:0000247
is: CHEBI:38290
has only substance units: false
initial concentration: 1.0
name: L-ascorbate
is: HMDB00044

http://identifiers.org/biomodels.db/MODEL1310110023#_34bbf89c_935f_4ae2_8ca7_450167007d0e
type: Species
is: P43251
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:686
has only substance units: false
name: BTD
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110023#_9368447e_4eb5_46e5_afba_fd6931c576d4
is: B4DX62
initial amount: NaN
is encoded by: hsa:6487
has only substance units: false
is: SBO:0000252
name: ST3GAL3
initial concentration: NaN
constant: false
boundary condition: true
type: Species

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

metaR GALASE5ly
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
is: SBO:0000176
fast: false
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
product: MODEL1310110023#
name: beta-galactosidase, lysosomal
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4

http://identifiers.org/biomodels.db/MODEL1310110023#_737fb0e5_37e1_43b0_a0db_cf702b93f9d5
has only substance units: false
is encoded by: hsa:4720
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
is: B7Z792
initial amount: NaN
constant: false
name: NDUFS2

http://identifiers.org/biomodels.db/MODEL1310110023#_142202a4_8b3d_4b6b_b31d_685a694d8588
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:54898
name: ELOVL2
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
is: Q9NXB9

metaM 3hdcoa m
constant: false
boundary condition: false
name: (S)-3-Hydroxydecanoyl-CoA
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C31H50N7O18P3S CHARGE: -4

metaR r2338
is described by: ECO:0000000
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
product: MODEL1310110023#
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110023#
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
is: SBO:0000185

metaR NDPK1n
fast: false
reversible: true
modifier: MODEL1310110023#
type: Reaction
is: SBO:0000176
product: MODEL1310110023#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:GDP), nuclear
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:15242782 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.

metaR r0942
is: SBO:0000185
product: MODEL1310110023#
type: Reaction
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:
is described by: ECO:0000000
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
fast: false
reactant: MODEL1310110023#
reversible: true

metaM Ser Thr g
is: CHEBI:58336
is: SBO:0000247
notes: FORMULA: XH CHARGE: 0
type: Species
boundary condition: false
name: protein-linked serine or threonine residue (O-glycosylation site)
initial amount: NaN
constant: false
is: HMDB00645
has only substance units: false
initial concentration: 1.0

metaR ASPTA
product: MODEL1310110023#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
kinetic law: MODEL1310110023#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110023#
name: aspartate transaminase
modifier: MODEL1310110023#
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.1
reversible: true

metaR r1597
product: MODEL1310110023#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
reactant: MODEL1310110023#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110023#

metaR OIVD3m
is: SBO:0000176
name: 2-oxoisovalerate dehydrogenase (acylating; 3-methyl-2-oxopentanoate), mitochondrial
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1629.1) and (594.1 and 593.1) and (1738.1) or (1629.1) and (1738.1) and (594.2 and 593.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:1429740,PMID:2914958 NOTES:
fast: false
type: Reaction
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.2.4.4
reversible: false
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/2.3.1.168
reactant: MODEL1310110023#

metaR r2124
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110023#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110023#
is described by: ECO:0000000
modifier: MODEL1310110023#
product: MODEL1310110023#
is: SBO:0000185
fast: false

metaM hom L c
initial concentration: 1.0
name: L-homoserine
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:15699
is: SBO:0000247
has only substance units: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
is: HMDB00719
constant: false

metaR SPC HSt
product: MODEL1310110023#
reversible: true
fast: false
name: sphingosylphosphorylcholine transport (diffusion)
is: SBO:0000185
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069827 NOTES:
reactant: MODEL1310110023#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110023#_d1b3117e_e7f1_4383_ada4_c5357a2b4925
is encoded by: hsa:8818
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
has part: P37287
is encoded by: hsa:5277
has only substance units: false
is: SBO:0000297
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
constant: false

metaM tsul e
is: SBO:0000247
is: HMDB00257
type: Species
is: CHEBI:16094
name: thiosulfate(2-)
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
has only substance units: false

metaR MTHFD
name: methylenetetrahydrofolate dehydrogenase (NADP)
is described by: ECO:0000134
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.5
notes: GENE_ASSOCIATION: (4522.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
reactant: MODEL1310110023#
product: MODEL1310110023#
reversible: true
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
is: SBO:0000176

metaR NDPK1m
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is: SBO:0000176
type: Reaction
product: MODEL1310110023#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110023#
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
reversible: true
is described by: ECO:0000254
reactant: MODEL1310110023#
modifier: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_e585cfb6_5122_4031_b45e_ab91f5b82bab
constant: false
has only substance units: false
name: FECH
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:2235
is: P22830

metaR r1596
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110023#
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000

metaM 4hexdtricoa x
is: HMDB02288
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
initial amount: NaN
type: Species
boundary condition: false
name: 4,7,10-hexadecatrienoylcoa
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110023#_e5d5ef9d_533e_43a5_b48d_9c957e08d84a
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: LDHAL6A
type: Species
is: Q6ZMR3
is encoded by: hsa:160287
has only substance units: false
is: SBO:0000252
constant: false

metaR GDPFUCtg
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reversible: true
is described by: ECO:0000269
type: Reaction
fast: false
is: SBO:0000185
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (55343.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11326279,PMID:11326280 NOTES:NCD
name: GDPFuc Golgi transport via CMP antiport

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_8bde7df8_7750_4da8_9c95_bb7968a93e63
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:51
initial amount: NaN
name: ACOX1
is: B4DK61

metaR r2125
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000185
product: MODEL1310110023#
fast: false
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR RE1804M
reversible: true
is version of: http://identifiers.org/ec-code/1.14.13.15
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
fast: false
product: MODEL1310110023#
name: RE1804
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
is described by: ECO:0000000

metaM pail5p hs c
is: CHEBI:57795
boundary condition: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)

metaR r1595
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110023#
type: Reaction
reversible: true
reactant: MODEL1310110023#
is described by: ECO:0000000

metaR LTC4CP
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
is: SBO:0000176
kinetic law: MODEL1310110023#
reversible: true
type: Reaction
fast: false
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000000
name: Leukotriene C4 carboxypeptidase

metaR r1177
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
product: MODEL1310110023#
reversible: false
type: Reaction
fast: false
name: EC:3.1.1.13

metaR EX leuktrC4 LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leukotriene C4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_1c5ad6d3_2ff0_4a6f_81da_284edf60e459
boundary condition: true
initial concentration: NaN
is encoded by: hsa:7296
name: TXNRD1
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false

metaM chol n
is: CHEBI:15354
name: choline
has only substance units: false
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
boundary condition: false
is: SBO:0000247
is: HMDB00097
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0

metaR GTHOm
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/1.8.1.7
modifier: MODEL1310110023#
fast: false
product: MODEL1310110023#
name: glutathione oxidoreductase
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558,PMID:15149466 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
reactant: MODEL1310110023#
reversible: false

metaM ahcys m
type: Species
constant: false
is: C00021
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
initial concentration: 1.0
is: HMDB00939
name: S-Adenosyl-L-homocysteine
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:16680
initial amount: NaN

metaR EX vacc LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: vaccenic acid exchange
type: Reaction

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

metaM dcsptn1crn m
is: SBO:0000247
boundary condition: false
is: HMDB06321
name: docosa-4,7,10,13,16-pentaenoyl carnitine
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+

http://identifiers.org/biomodels.db/MODEL1310110023#_e32b4158_d1e4_4eab_9794_e49ed9a23727
is: SBO:0000252
is encoded by: hsa:160851
is: A8K0I1
boundary condition: true
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
has only substance units: false
name: DGKH

http://identifiers.org/biomodels.db/MODEL1310110023#_8524d821_d5e8_41c6_94cb_1232a3864a39
is: P19367
initial concentration: NaN
boundary condition: true
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
name: HK1
is encoded by: hsa:3098
has only substance units: false

metaR DOPASULT
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.8.2.1
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/2005)
product: MODEL1310110023#
is described by: ECO:0000269
modifier: MODEL1310110023#
reversible: false
name: Dopamine Sulfotransferase
fast: false
type: Reaction
is: SBO:0000176

metaM pdx5p c
type: Species
initial concentration: 1.0
is: CHEBI:58589
is: C00627
is: HMDB01319
name: Pyridoxine 5'-phosphate
is: SBO:0000247
has only substance units: false
notes: FORMULA: C8H10NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00459 EHMN_ABBREVIATION: C00627
constant: false
initial amount: NaN
boundary condition: false

metaR FAOXC164C165m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:5)m
type: Reaction

metaR r1594
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110023#
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110023#
reactant: MODEL1310110023#

metaR RE3567C
kinetic law: MODEL1310110023#
fast: false
is described by: ECO:0000000
is: SBO:0000176
reversible: true
name: RE3567
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
type: Reaction
product: MODEL1310110023#
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_5b1a0dc3_327d_4840_94b4_013b9e368048
initial concentration: NaN
constant: false
name: GALT
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:2592
has only substance units: false
is: B2RAT6

metaM ala L m
name: L-alanine
type: Species
is: HMDB00161
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:16977
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
constant: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110023#_0f365508_e81c_424c_9fa9_f5940b9fd850
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

metaM 2dp6mobq me m
name: 2-decaprenyl-6-methoxy-3-methyl-1,4-benzoquinone
notes: FORMULA: C58H88O3 CHARGE: 0 INCHI: InChI=1S/C58H88O3/c1-44(2)23-14-24-45(3)25-15-26-46(4)27-16-28-47(5)29-17-30-48(6)31-18-32-49(7)33-19-34-50(8)35-20-36-51(9)37-21-38-52(10)39-22-40-53(11)41-42-55-54(12)56(59)43-57(61-13)58(55)60/h23,25,27,29,31,33,35,37,39,41,43H,14-22,24,26,28,30,32,34,36,38,40,42H2,1-13H3/b45-25+,46-27+,47-29+,48-31+,49-33+,50-35+,51-37+,52-39+,53-41+
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:50772

metaR RNDR4
name: ribonucleoside-diphosphate reductase (UDP)
fast: false
product: MODEL1310110023#
reversible: false
reactant: MODEL1310110023#
is described by: ECO:0000254
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.17.4.1
modifier: MODEL1310110023#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:

metaM mthgxl c
initial amount: NaN
is: HMDB01167
initial concentration: 1.0
name: methylglyoxal
is: SBO:0000247
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
constant: false
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:17158

metaR r0660
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.2
fast: false
kinetic law: MODEL1310110023#
reversible: true
is: SBO:0000176
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
product: MODEL1310110023#
type: Reaction
modifier: MODEL1310110023#

metaM memgacpail hs r
is: HMDB00054
is: SBO:0000247
type: Species
is: CHEBI:57977
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C45H84N2O27P2FULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
name: (mannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (B)
initial amount: NaN

metaM b2coa m
is: CHEBI:57332
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
initial concentration: 1.0
type: Species
constant: false
is: HMDB02009
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: crotonoyl-CoA(4-)
boundary condition: false

metaR r1593
is described by: ECO:0000000
kinetic law: MODEL1310110023#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction
product: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true

metaR CRNt
kinetic law: MODEL1310110023#
is: SBO:0000185
reactant: MODEL1310110023#
is described by: ECO:0000269
reversible: true
product: MODEL1310110023#
modifier: MODEL1310110023#
type: Reaction
name: L-carnitine reversible transport
fast: false
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD

metaM HC02217 e
boundary condition: false
has only substance units: false
is: CHEBI:27647
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
constant: false
name: prostaglandin-g2
type: Species
is: SBO:0000247

metaM maltttr e
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052
is: SBO:0000247
is: C02052
constant: false
name: Maltotetraose
initial concentration: 1.0
is: HMDB01296
is: http://identifiers.org/pubchem.compound/5141
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species

metaM 3mop m
constant: false
initial amount: NaN
has only substance units: false
is: HMDB00491
boundary condition: false
type: Species
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
name: 3-methyl-2-oxopentanoate
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28654

metaR RNDR1
reactant: MODEL1310110023#
fast: false
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/1.17.4.1
modifier: MODEL1310110023#
reversible: false
product: MODEL1310110023#
name: ribonucleoside-diphosphate reductase (ADP)
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_2450ab8a_8915_4ee0_b9a5_693aae04b323
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:50
name: ACO2
is: Q99798
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
constant: false

metaR PNTOte
name: Transport of (R)-Pantothenate
product: MODEL1310110023#
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
fast: false
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#

metaR OCDCEAtr
reversible: true
name: fatty acid transport via diffusion
kinetic law: MODEL1310110023#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110023#
fast: false
product: MODEL1310110023#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110023#_25e493f5_5f04_43e3_9609_66db52512353
is: SBO:0000252
is: P60891
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5631
constant: false
name: PRPS1

metaR r2128
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110023#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110023#
reversible: true
type: Reaction
kinetic law: MODEL1310110023#
product: MODEL1310110023#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110023#_c0a36a21_0c3f_43a2_844b_2b6309932311
constant: false
is: O43488
type: Species
boundary condition: true
is: SBO:0000252
name: AKR7A2
has only substance units: false
initial amount: NaN
is encoded by: hsa:8574
initial concentration: NaN

metaR EX estradiol LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: estradiol exchange
type: Reaction

metaM tcynt c
type: Species
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB01453
initial amount: NaN
has only substance units: false
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
name: thiocyanate
initial concentration: 1.0
is: CHEBI:18022

http://identifiers.org/biomodels.db/MODEL1310110023#_762ca763_83aa_4472_aa03_cd242169dc21
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
name: RBAK
initial concentration: NaN
is: Q9NYW8
is encoded by: hsa:57786
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_908a1adf_0a35_4ba4_8921_c12d9522c24a
initial amount: NaN
initial concentration: NaN
name: SLC38A5
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
is: Q8WUX1
is encoded by: hsa:92745
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_635581e7_9db2_4419_b9af_04c2e6b2714c
is encoded by: hsa:956
has only substance units: false
name: ENTPD3
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
is: O75355
initial concentration: NaN
type: Species

metaM Rtotal2coa c
type: Species
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4
initial amount: NaN
is: CHEBI:57876
is: HMDB01564
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
name: R total 2 coenzyme A

http://identifiers.org/biomodels.db/MODEL1310110023#_36b36bd7_cce0_4163_8d4b_e44b26c2db98
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:4830
initial amount: NaN
constant: false
is: SBO:0000252
is: P15531
name: NME1
boundary condition: true

metaR FAOXC1811603m
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
modifier: MODEL1310110023#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110023#
reversible: false
name: Beta oxidation fatty acid
reactant: MODEL1310110023#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3

http://identifiers.org/biomodels.db/MODEL1310110023#_adeb5e90_5d51_493d_a46d_cb2e34154677
has only substance units: false
name: BCKDHB
is: P21953
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:594
boundary condition: true
constant: false
type: Species

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_a2c99000_5f7f_42de_8f1a_c39e65849508
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:3028
is: Q99714
name: HSD17B10
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false

metaR r1592
is: SBO:0000185
reactant: MODEL1310110023#
fast: false
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110023#
is described by: ECO:0000000

metaM 2octdectecoa m
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
initial concentration: 1.0
boundary condition: false
name: 2,6,9,12-octadecatetraenoylcoa
type: Species
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB02288

metaR RNDR2
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.17.4.1
type: Reaction
modifier: MODEL1310110023#
name: ribonucleoside-diphosphate reductase (GDP)
is described by: ECO:0000254
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
reversible: false
product: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110023#_2084a2c5_528b_4e4d_8b60_a152ac60108e
name: GALE
type: Species
boundary condition: true
constant: false
is encoded by: hsa:2582
has only substance units: false
initial amount: NaN
is: Q14376
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_3adaab38_b38a_4219_9e50_4c3c8d0f33f5
is encoded by: hsa:2271
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: P07954
name: FH

http://identifiers.org/biomodels.db/MODEL1310110023#_665900fc_6f3a_4c60_b3a4_4ff2f353dd5d
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: _LOC727762_1_m
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:LOC727762
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110023#_fa3ba84d_ff53_4de0_b3ea_aa4500d9bf6d
is encoded by: hsa:374291
is: O75251
is: SBO:0000252
constant: false
initial concentration: NaN
name: NDUFS7
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_a2f0f643_8608_4b67_b314_a900ac31ada5
initial amount: NaN
is: P25092
name: GUCY2C
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:2984

metaR r2129
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110023#
product: MODEL1310110023#
type: Reaction
reactant: MODEL1310110023#
modifier: MODEL1310110023#

metaM 4aphdob c
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58147
constant: false
boundary condition: false
is: HMDB00978
is: SBO:0000247
has only substance units: false
type: Species

metaR r2332
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
type: Reaction
product: MODEL1310110023#

metaM cspg b l
type: Species
boundary condition: false
initial amount: NaN
constant: false
is: HMDB02183
is: SBO:0000247
has only substance units: false
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
initial concentration: 1.0
is: CHEBI:36005
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan

metaM HC02217 c
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
is: CHEBI:27647
name: prostaglandin-g2
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false

metaR r1591
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110023#
product: MODEL1310110023#
type: Reaction
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
reversible: true
is described by: ECO:0000000

metaM 2docopencoa m
is: SBO:0000247
has only substance units: false
name: 2,7,10,13,16-docosapentenoylcoa
constant: false
type: Species
initial amount: NaN
is: HMDB02288
boundary condition: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
initial concentration: 1.0

metaM gthrd m
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
name: glutathionate(1-)
is: HMDB00125
is: CHEBI:57925
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051

metaM dtdp c
is: SBO:0000247
is: HMDB01274
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
initial amount: NaN
name: dTDP
constant: false
initial concentration: 1.0
is: CHEBI:58369
type: Species
has only substance units: false
boundary condition: false
is: C00363

metaM gdp e
is: SBO:0000247
initial concentration: 1.0
name: GDP(3-)
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
boundary condition: false
is: HMDB01201
has only substance units: false
is: CHEBI:58189
type: Species
initial amount: NaN
constant: false

metaM ksii core2 deg2 l
notes: FORMULA: C70H114N5O56S2X CHARGE: -2
boundary condition: false
name: keratan sulfate II (core 2-linked), degradation product 2
is: HMDB00143
has only substance units: false
is: CHEBI:12936
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_24172840_df95_4196_afcd_d53a6fec59e3
initial concentration: NaN
is: Q16790
is encoded by: hsa:768
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
name: CA9
constant: false
initial amount: NaN

metaM fe3 c
initial concentration: 1.0
name: Fe3+
is: HMDB12943
type: Species
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: Fe CHARGE: 3
initial amount: NaN

metaR r2333
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
product: MODEL1310110023#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
is described by: ECO:0000000

metaR RE1845X
is: SBO:0000176
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.65
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 1 h[c] from compEHMN reaction as they were not necessary
name: RE1845
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110023#

metaR r1590
product: MODEL1310110023#
reversible: true
reactant: MODEL1310110023#
is: SBO:0000185
kinetic law: MODEL1310110023#
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110023#_4383c6d3_19ae_40ec_91fe_d6e8b1e6b32f
boundary condition: true
name: UPB1
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:51733
is: SBO:0000252
constant: false
is: B3KNC1
has only substance units: false
type: Species

metaR PAIL HStn
is: SBO:0000185
reactant: MODEL1310110023#
is described by: ECO:0000000
product: MODEL1310110023#
kinetic law: MODEL1310110023#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
name: phosphatidylinositol nuclear transport (diffusion)
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_7b79bad7_f883_4521_9c56_8be44856f83d
is encoded by: hsa:8875
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: VNN2
initial concentration: NaN
constant: false
has only substance units: false
is: O95498

metaR G14T19g
reversible: false
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110023#
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (9334.1) or (8704.1) or (8703.1) or (8704.2) or (2683.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false

metaM 4hglusa m
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938
initial concentration: 1.0
name: L-4-hydroxyglutamic semialdehyde
is: HMDB06556
is: CHEBI:27809
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_588a9c84_4b9b_4c5e_9bba_f5a71eb33cac
boundary condition: true
name: PIK3CD
constant: false
initial amount: NaN
is encoded by: hsa:5293
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
is: A7E2E0

metaM 10fthf e
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:57454
type: Species
has only substance units: false
constant: false
name: 10-formyltetrahydrofolate(2-)
boundary condition: false
is: HMDB00972

http://identifiers.org/biomodels.db/MODEL1310110023#_05d7f6e6_36e2_4eeb_9315_a1a09ac53f11
is encoded by: hsa:5152
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
name: PDE9A
initial amount: NaN
initial concentration: NaN
type: Species

metaR IDOAASE1ly
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
modifier: MODEL1310110023#
name: alpha-L-iduronidase, lysosomal
reversible: false
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.2.1.76
fast: false
is described by: ECO:0000000
product: MODEL1310110023#
type: Reaction
kinetic law: MODEL1310110023#
is: SBO:0000176

metaR EX pydx5p LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of pyridoxal 5-phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_81b7e291_9435_439c_9b4d_22083d787667
is: SBO:0000252
is: Q8TD20
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is encoded by: hsa:154091
initial amount: NaN
name: SLC2A12

metaR r2330
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110023#
type: Reaction
is: SBO:0000185
product: MODEL1310110023#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
kinetic law: MODEL1310110023#
fast: false

metaM ksi pre8 g
type: Species
initial concentration: 1.0
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 8
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C115H186N8O88S2X CHARGE: -3
is: CHEBI:28067
boundary condition: false

metaM gdp c
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
is: C00035
is: SBO:0000247
has only substance units: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: HMDB01201
name: GDP
is: CHEBI:58189
type: Species

metaM dtdp e
initial amount: NaN
is: HMDB01274
constant: false
is: CHEBI:58369
type: Species
initial concentration: 1.0
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
boundary condition: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110023#_8055b7ef_78cb_4208_9188_0afc0ce31089
initial amount: NaN
type: Species
is encoded by: hsa:89874
initial concentration: NaN
is: SBO:0000252
constant: false
name: SLC25A21
is: G3V4L5
boundary condition: true
has only substance units: false

metaM retinol 9 cis c
initial amount: NaN
constant: false
type: Species
name: 9-cis-retinol
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB06217
is: CHEBI:17336

metaM ile L c
initial amount: NaN
is: HMDB00172
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: CHEBI:17191
type: Species
name: L-isoleucine
initial concentration: 1.0
has only substance units: false

metaR LNSTLSr
reactant: MODEL1310110023#
fast: false
is version of: http://identifiers.org/ec-code/5.4.99.7
is: SBO:0000176
is described by: ECO:0000134
modifier: MODEL1310110023#
product: MODEL1310110023#
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (4047.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.4.99.7 Confidence Level: 2 AUTHORS: PMID:17925399,PMID:17925400,PMID:18830876,PMID:18830877 NOTES:NCD ER version - NJ
type: Reaction
reversible: false
name: lanosterol synthase

http://identifiers.org/biomodels.db/MODEL1310110023#_7d4e7412_1919_4047_96d1_19b6f7333c98
is: Q16873
boundary condition: true
is encoded by: hsa:4056
initial amount: NaN
name: LTC4S
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false

metaR RE3346C
name: RE3346
reactant: MODEL1310110023#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110023#
reversible: true
type: Reaction
product: MODEL1310110023#
fast: false
modifier: MODEL1310110023#
is: SBO:0000176
notes: GENE_ASSOCIATION: (223.1) or (218.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.3

metaR r2331
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110023#
is: SBO:0000185
product: MODEL1310110023#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
kinetic law: MODEL1310110023#
fast: false

metaR ACGAMPM
fast: false
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD
is: SBO:0000176
name: phosphoacetylglucosamine mutase
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/5.4.2.3
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110023#
modifier: MODEL1310110023#
type: Reaction
product: MODEL1310110023#

metaR FUM
name: fumarase
modifier: MODEL1310110023#
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/4.2.1.2
is described by: ECO:0000000
reactant: MODEL1310110023#
is: SBO:0000176
kinetic law: MODEL1310110023#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: NOTES:
fast: false

metaM 10fthf c
is: HMDB00972
initial concentration: 1.0
is: C00234
initial amount: NaN
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: SBO:0000247
has only substance units: false
name: 10-Formyltetrahydrofolate
boundary condition: false
is: CHEBI:57454
type: Species
constant: false

metaM 1pyr5c c
is: CHEBI:15893
is: SBO:0000247
name: 1-Pyrroline-5-carboxylate
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
is: C03912
type: Species
initial amount: NaN
is: HMDB01301
boundary condition: false
constant: false

metaM tmndnccoa c
initial concentration: 1.0
is: HMDB06514
constant: false
name: timnodonyl coenzyme A
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1

metaR S6TASE10ly
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
type: Reaction
product: MODEL1310110023#
modifier: MODEL1310110023#
name: galactose-6-sulfate sulfatase, lysosomal
reversible: true
is described by: ECO:0000000

metaM tsul m
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
has only substance units: false
is: CHEBI:16094
name: thiosulfate(2-)
boundary condition: false
is: HMDB00257
type: Species

metaR MDHm
is: SBO:0000176
reversible: true
fast: false
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
product: MODEL1310110023#
modifier: MODEL1310110023#
name: malate dehydrogenase, mitochondrial
is version of: http://identifiers.org/ec-code/1.1.1.37
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
type: Reaction
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110023#_b7172f39_a299_45d4_9cc8_11f4beca868f
has only substance units: false
boundary condition: true
is: SBO:0000252
name: AK2
initial concentration: NaN
is encoded by: hsa:204
type: Species
is: P54819
constant: false
initial amount: NaN

metaM udp c
type: Species
is: HMDB00295
name: UDP
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:58223
is: SBO:0000247
constant: false
is: C00015
boundary condition: false

metaM dtdp n
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
initial amount: NaN
is: HMDB01274
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:58369
is: SBO:0000247

metaR EX Rtotal3 LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 3 position exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_e5e5405f_bfff_4020_a7fb_ed11421fb21d
is: P51178
initial concentration: NaN
type: Species
is: SBO:0000252
name: PLCD1
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:5333

metaR DNDPt14m
name: dUDP transport via dTDP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
kinetic law: MODEL1310110023#
fast: false
is: SBO:0000185
reversible: false
reactant: MODEL1310110023#
modifier: MODEL1310110023#
is described by: ECO:0000269
product: MODEL1310110023#

metaM trdrd c
name: Reduced thioredoxin
initial concentration: 1.0
is: CHEBI:15967
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
boundary condition: false
initial amount: NaN
has only substance units: false
is: C00342
constant: false
is: SBO:0000247
type: Species

metaM bhb e
is: HMDB00011
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:10983
name: (R)-3-hydroxybutyrate
constant: false
has only substance units: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089

metaR r0668
kinetic law: MODEL1310110023#
fast: false
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
is: SBO:0000176
reactant: MODEL1310110023#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.19
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
modifier: MODEL1310110023#
product: MODEL1310110023#
is described by: ECO:0000000

metaM cs a deg1 l
constant: false
has only substance units: false
type: Species
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
is: CHEBI:57455
is: SBO:0000247
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 1
boundary condition: false
is: HMDB01354
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_242cb031_527c_475b_b6e9_24db7207886a
initial amount: NaN
type: Species
is encoded by: hsa:AL038231
name: _AL038231_1_c
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN

metaM hedepecoa m
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C37H52N7O17P3S CHARGE: -4
name: 2,4,7,10,13-hexadecapentenoylcoa
is: HMDB02288
constant: false

metaR HAtly
product: MODEL1310110023#
kinetic law: MODEL1310110023#
is: SBO:0000185
reversible: false
is described by: ECO:0000000
name: hyaluronan transport, extracellular to lysosome
type: Reaction
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false

metaM h2o c
notes: FORMULA: H2O CHARGE: 0
is: C00001
is: HMDB02111
initial concentration: 1.0
name: H2O
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:3303
initial amount: NaN
has only substance units: false
type: Species

metaM 3hdcoa c
has only substance units: false
type: Species
initial amount: NaN
constant: false
name: (S)-3-Hydroxydecanoyl-CoA
is: SBO:0000247
boundary condition: false
is: CHEBI:57449
notes: FORMULA: C31H50N7O18P3S CHARGE: -4
initial concentration: 1.0

metaR GALASE7ly
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110023#
modifier: MODEL1310110023#
fast: false
name: beta-galactosidase, lysosomal
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110023#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false

metaM ala L e
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
constant: false
name: L-alanine
is: HMDB00161
type: Species
boundary condition: false
is: CHEBI:16977
initial concentration: 1.0

metaR r1447
product: MODEL1310110023#
kinetic law: MODEL1310110023#
reversible: false
is: SBO:0000176
type: Reaction
name: EC:1.3.3.6
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
reactant: MODEL1310110023#
is described by: ECO:0000000
fast: false

metaR EX inost LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: myo-Inositol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_af81d9f9_5a40_4f1d_b573_fc73ac6dbfcf
boundary condition: true
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:83594
is: Q9BQG2
name: NUDT12
has only substance units: false

metaR COUCOAFm
reversible: false
is: SBO:0000176
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: 6.2.1.12 Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine. (EC 6.2.1.12) .
is described by: ECO:0000000
type: Reaction
name: p-coumaroyl-CoA formation
fast: false
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#

metaM cholcoaone x
initial concentration: 1.0
name: 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA(4-)
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C48H74N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-30,32-34,36,38-40,44,56,58-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/p-4/t24-,25?,26+,27-,28-,29+,30+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01473 EHMN_ABBREVIATION: C05467
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:58507
is: HMDB06891

metaR PROSTGE2t
is described by: ECO:0000269
kinetic law: MODEL1310110023#
is: SBO:0000185
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
product: MODEL1310110023#
reactant: MODEL1310110023#
name: prostaglandin transport via bicarbonate countertransport
reversible: true
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_56ef14cd_afd0_4d9b_bc06_b4d9af45b4da
type: Species
is encoded by: hsa:55568
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: GALNT10
has only substance units: false

metaM h2o e
is: C00001
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: SBO:0000247
name: H2O
is: CHEBI:15377
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
is: HMDB02111
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_a8dd1ce6_6d0e_45c3_8a33_4fd8c7fea352
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: TUSC3
constant: false
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:7991

metaM gthrd r
is: HMDB00125
name: glutathionate(1-)
is: CHEBI:57925
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
has only substance units: false
boundary condition: false

metaM gar c
has only substance units: false
type: Species
name: N1-(5-Phospho-D-ribosyl)glycinamide
initial amount: NaN
is: CHEBI:58457
constant: false
is: HMDB02022
initial concentration: 1.0
is: SBO:0000247
is: C03838
boundary condition: false
notes: FORMULA: C7H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01190 EHMN_ABBREVIATION: C03838

metaM leuktrF4 e
initial amount: NaN
name: leukotriene F4
has only substance units: false
is: SBO:0000247
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB06465
constant: false
is: CHEBI:27491

metaM leuleu e
has only substance units: false
is: http://identifiers.org/pubchem.compound/94244
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C12H24N2O3 CHARGE: 0
type: Species
is: SBO:0000247
name: Leucylleucine

http://identifiers.org/biomodels.db/MODEL1310110023#_0c638dce_cba3_49b5_9917_c9a4a4e197ff
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6508
constant: false
type: Species
name: SLC4A3

metaR r0666
is version of: http://identifiers.org/ec-code/1.2.4.2
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Purine synthesis EC Number: 6.3.3.1 Confidence Level: 0 AUTHORS: PMID:4084560 NOTES:
is described by: ECO:0000000
product: MODEL1310110023#
name: 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) Purine metabolism EC:6.3.3.1
is: SBO:0000176
reactant: MODEL1310110023#
type: Reaction
fast: false
reversible: true

metaM dcsptn1crn c
is: SBO:0000247
name: docosa-4,7,10,13,16-pentaenoyl carnitine
is: HMDB06321
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
boundary condition: false
initial amount: NaN
constant: false

metaM amp x
has only substance units: false
initial amount: NaN
is: HMDB00045
constant: false
is: C00020
name: AMP
is: CHEBI:456215
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020

metaR r0779
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
is: SBO:0000176
type: Reaction
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
reversible: false
fast: false
modifier: MODEL1310110023#
is described by: ECO:0000000
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/4.2.1.17

metaM CE5161 r
is: SBO:0000247
initial amount: NaN
name: 3(S)-hydroxy-cis-9-octadecenoyl-CoA
initial concentration: 1.0
is: CHEBI:57923
constant: false
has only substance units: false
type: Species
notes: FORMULA: C39H64N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-28,32-34,38,47,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5161
boundary condition: false

metaR r2447
fast: false
product: MODEL1310110023#
name: Concentrative Nucleoside Transporter (CNT) TCDB:2.A.41.2.3
reversible: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#

metaM hdca r
name: Hexadecanoate (n-C16:0)
is: CHEBI:7896
has only substance units: false
is: HMDB00220
initial concentration: 1.0
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
boundary condition: false
type: Species
initial amount: NaN
is: C00249
constant: false
is: SBO:0000247

metaR CYSSNAT5tc
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_fe54dbbe_d648_4a89_bed7_6714127c3ff4
boundary condition: true
name: _BF195998_1_x
is encoded by: hsa:BF195998
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_e060bf8a_0b22_4e31_b10f_d6fdcc95e28f
is encoded by: hsa:7498
is: P47989
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
name: XDH
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110023#_2dd04b1e_d3a6_4deb_a2dd_a259da03b059
is encoded by: hsa:23556
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
name: PIGN

http://identifiers.org/biomodels.db/MODEL1310110023#_0cd2b359_4640_45ac_add9_b4f1baa30fb5
name: _R51273_1_c
boundary condition: true
is: SBO:0000252
is encoded by: hsa:R51273
type: Species
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaR DHCR71r
is: SBO:0000176
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:9465114 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
reactant: MODEL1310110023#
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.21
name: 7-dehydrocholesterol reductase
type: Reaction
modifier: MODEL1310110023#
is described by: ECO:0000134
product: MODEL1310110023#
reversible: false
kinetic law: MODEL1310110023#

metaM HC01609 e
boundary condition: false
is: CHEBI:28766
initial concentration: 1.0
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
name: UroporphyrinogenI
has only substance units: false

metaM vacccoa c
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h9-10,26-28,32-34,38,49-50H,4-8,11-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b10-9+/t28-,32-,33?,34+,38-/m1/s1
is: SBO:0000247
name: vaccenyl coenzyme A
boundary condition: false
has only substance units: false
type: Species
is: HMDB06521
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/9543677
initial concentration: 1.0

metaR P45011A1m
product: MODEL1310110023#
type: Reaction
modifier: MODEL1310110023#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1583.1) SUBSYSTEM: Steroid metabolism EC Number: 1.14.15.67 Confidence Level: 4 AUTHORS: PMID:16232916 NOTES:reaction sequence mx steps, grouped into single reaction uses adrenal ferredoxin NJ
fast: false
name: Cytochrome P450 11A1, mitochondrial [Precursor]
is version of: http://identifiers.org/ec-code/1.14.15.6
kinetic law: MODEL1310110023#
reversible: false
reactant: MODEL1310110023#
is: SBO:0000176

metaR GLYSNAT5tc
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_c4fe1f50_b5b5_41ca_b7ab_74cec49b5298
is encoded by: hsa:10390
has only substance units: false
name: CEPT1
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
is: B3KN25

metaM udp g
is: SBO:0000247
constant: false
type: Species
name: UDP(3-)
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
initial amount: NaN
is: CHEBI:58223
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB00295

metaR LNELDCCRNt
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000185
kinetic law: MODEL1310110023#
product: MODEL1310110023#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110023#
fast: false
reversible: false
name: transport into the mitochondria (carnitine)

http://identifiers.org/biomodels.db/MODEL1310110023#_4b4b9aae_b207_4ba3_b3a7_3ac314d2e8ee
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:48
constant: false
has only substance units: false
is: P21399
is: SBO:0000252
name: ACO1
initial amount: NaN

metaM fru c
is: SBO:0000247
is: HMDB00660
initial amount: NaN
is: C00095
is: CHEBI:15824
boundary condition: false
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
initial concentration: 1.0
has only substance units: false
name: D-Fructose
constant: false

metaM amp r
is: HMDB00045
boundary condition: false
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: C00020
is: CHEBI:456215
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: SBO:0000247
name: AMP
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110023#_cf9c7290_dd2d_486b_951b_74095cfcda81
is encoded by: hsa:4831
is: SBO:0000297
boundary condition: true
is encoded by: hsa:4830
constant: false
initial concentration: NaN
has part: P15531
name: NME1:NME2
has only substance units: false
has part: P22392
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_e2fc202f_f2c0_40ae_9303_3948dac223eb
constant: false
is: O94778
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:343
name: AQP8

metaM ksi deg21 l
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB00143
is: CHEBI:12936
initial amount: NaN
notes: FORMULA: C132H213N9O114S6 CHARGE: -6
constant: false
name: keratan sulfate I, degradation product 21

http://identifiers.org/biomodels.db/MODEL1310110023#_310ecb2e_f7a9_41dc_8dfc_945f68057ac1
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: TPK1
is: F5GZG6
constant: false
type: Species
has only substance units: false
is encoded by: hsa:27010

metaR MM5ag
is version of: http://identifiers.org/ec-code/3.2.1.113
reversible: false
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
fast: false
product: MODEL1310110023#
is: SBO:0000176
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
reactant: MODEL1310110023#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_62e3c5d2_8315_4b12_8cb4_b849a72ce221
constant: false
type: Species
is encoded by: hsa:4704
boundary condition: true
name: NDUFA9
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: Q16795
has only substance units: false

metaR PIter
reversible: true
product: MODEL1310110023#
modifier: MODEL1310110023#
is described by: ECO:0000212
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
name: phosphate transport, endoplasmic reticulum
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
is: SBO:0000185

metaR NACHEXA21ly
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
name: beta-N-acetylhexosaminidase A, lysosomal
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
reactant: MODEL1310110023#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110023#
product: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_af715143_c6db_429e_8dcd_a52acbc0a00c
initial concentration: NaN
initial amount: NaN
name: PNPLA4
is encoded by: hsa:8228
type: Species
is: P41247
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110023#_e97ea59c_bac7_4656_971c_096c5d3daa23
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
type: Species
is: O00767
is encoded by: hsa:6319
initial concentration: NaN
name: SCD
initial amount: NaN

metaM acald e
has only substance units: false
name: acetaldehyde
constant: false
is: SBO:0000247
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
is: CHEBI:15343
is: HMDB00990
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species

metaM orn e
is: CHEBI:0
is: SBO:0000247
is: C01602
name: Ornithine
initial concentration: 1.0
notes: FORMULA: C5H13N2O2 CHARGE: 1
initial amount: NaN
is: HMDB00214
has only substance units: false
boundary condition: false
constant: false
type: Species

metaM cit m
is: HMDB00094
is: CHEBI:16947
has only substance units: false
is: C00158
boundary condition: false
constant: false
type: Species
name: Citrate
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

metaR RE1709C
product: MODEL1310110023#
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110023#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110023#
name: RE1709
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:

metaM lnlc r
is: CHEBI:30245
is: SBO:0000247
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC00796 EHMN_ABBREVIATION: C01595
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB00673
has only substance units: false
initial amount: NaN
name: linoleate

http://identifiers.org/biomodels.db/MODEL1310110023#_5f0b0da5_9b48_4f2c_b823_c365996c6d12
initial amount: NaN
has only substance units: false
name: B3GNT6
is encoded by: hsa:192134
type: Species
is: A8K9Q8
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaM udp e
is: HMDB00295
name: UDP(3-)
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
type: Species
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:58223
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaR EX lcts LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Lactose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_3fc44098_2f5b_4b5d_a811_346b16d6740a
has only substance units: false
initial amount: NaN
is: P18405
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6715
constant: false
type: Species
name: SRD5A1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110023#_ce24d00a_e60b_4a57_9422_34d774c1855c
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
name: SLC25A15
initial amount: NaN
is: Q9Y619
has only substance units: false
is encoded by: hsa:10166
boundary condition: true

metaR r0365
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.72
kinetic law: MODEL1310110023#
type: Reaction
is described by: ECO:0000000
fast: false
modifier: MODEL1310110023#
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
reactant: MODEL1310110023#
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59

http://identifiers.org/biomodels.db/MODEL1310110023#_d2b41cd7_e83c_4669_8aa6_fb82b554119f
boundary condition: true
is encoded by: hsa:954
has only substance units: false
is: SBO:0000252
type: Species
is: Q9Y5L3
initial amount: NaN
constant: false
name: ENTPD2
initial concentration: NaN

metaR ALACYSNaEx
product: MODEL1310110023#
kinetic law: MODEL1310110023#
fast: false
name: L-alanine/L-cysteine Na-dependent exchange (Ala-L in)
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110023#
is described by: ECO:0000269
is: SBO:0000185
reversible: false
reactant: MODEL1310110023#
type: Reaction

metaM bhb c
boundary condition: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
initial concentration: 1.0
is: HMDB00011
is: SBO:0000247
initial amount: NaN
is: CHEBI:10983
name: (R)-3-hydroxybutyrate
has only substance units: false
type: Species
constant: false

metaR P5CDm
is: SBO:0000176
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Glutamate metabolism EC Number: 1.5.1.12 Confidence Level: 4 AUTHORS: PMID:8621661,PMID:9700195 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.5.1.12
name: 1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
fast: false
product: MODEL1310110023#
is described by: ECO:0000269
reactant: MODEL1310110023#
modifier: MODEL1310110023#
reversible: false

metaR RE2666C
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7930586 NOTES:
reversible: false
is: SBO:0000176
type: Reaction
name: RE2666
reactant: MODEL1310110023#
is described by: ECO:0000000
fast: false
product: MODEL1310110023#

metaM dtdp m
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB01274
is: C00363
initial concentration: 1.0
name: dTDP
has only substance units: false
is: CHEBI:58369
constant: false
boundary condition: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363

metaR THMP
reversible: false
fast: false
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:11997266,PMID:8522961 NOTES:EC 3.1.3.- NCD
kinetic law: MODEL1310110023#
type: Reaction
name: thiamin phosphatase
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110023#

metaR DPMVDc
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4597.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added t product for elemental balancing.
product: MODEL1310110023#
name: diphosphomevalonate decarboxylase, cytosol
type: Reaction
fast: false
is: SBO:0000176
modifier: MODEL1310110023#
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.33
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#

metaM cspg b e
initial amount: NaN
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
is: HMDB00300
is: CHEBI:17568
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
is: SBO:0000247
is: C00106
constant: false

metaM dcholcoa x
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: chenodeoxycholoyl coenzyme a
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:28701
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
is: HMDB06292
constant: false

metaR FE3MTP1
is: SBO:0000185
is described by: ECO:0000134
fast: false
name: transport of ferrous iron into blood
kinetic law: MODEL1310110023#
type: Reaction
modifier: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (30061.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
reversible: false

metaM ala L c
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
name: L-alanine
is: CHEBI:16977
is: HMDB00161

metaR r2443
is: SBO:0000185
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110023#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110023#
type: Reaction
reactant: MODEL1310110023#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110023#_98fa27f0_6eeb_4c4d_ae93_bd281e160773
type: Species
initial concentration: NaN
name: ALG3
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:10195

metaM acald c
has only substance units: false
type: Species
name: acetaldehyde
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
constant: false
is: SBO:0000247
is: CHEBI:15343
boundary condition: false
is: HMDB00990
initial concentration: 1.0
initial amount: NaN

metaR COt
name: CO transporter via diffusion
is: SBO:0000185
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
reversible: true
product: MODEL1310110023#
fast: false
is described by: ECO:0000000
type: Reaction

metaR D 3AIBt
name: D-3-amino-isobutyrate transport
is: SBO:0000185
reactant: MODEL1310110023#
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110023#
fast: false
type: Reaction
reversible: false

metaM urate c
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
is: CHEBI:17775
name: Urate
is: HMDB00289
is: C00366
type: Species
has only substance units: false
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_59f67507_e530_4cbb_9a2a_f70cd11b1c9f
initial concentration: NaN
name: _728637_1_c
is encoded by: hsa:728637
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
type: Species

metaR RE1448N
type: Reaction
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
name: RE1448
reactant: MODEL1310110023#
is described by: ECO:0000000
product: MODEL1310110023#
reversible: true
fast: false
is: SBO:0000176

metaM dc2coa x
initial amount: NaN
is: HMDB01168
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
boundary condition: false
has only substance units: false
name: trans-Dec-2-enoyl-CoA
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110023#_3deafdee_ab9e_461c_8e1f_5479cb4ecc7c
boundary condition: true
type: Species
has part: Q02153
name: GUCY1A2:GUCY1B3
has only substance units: false
initial amount: NaN
is encoded by: hsa:2977
has part: P33402
is encoded by: hsa:2983
initial concentration: NaN
constant: false
is: SBO:0000297

metaM bhb m
type: Species
initial concentration: 1.0
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
name: (R)-3-hydroxybutyrate
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB00011
is: CHEBI:10983
initial amount: NaN

metaR BTNPL
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
name: holocarboxylase synthestase (biotin protein ligase)
kinetic law: MODEL1310110023#
reversible: false
modifier: MODEL1310110023#
fast: false
is version of: http://identifiers.org/ec-code/6.3.4.10
product: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_c557553f_40de_4080_8c07_8d50f833255f
type: Species
boundary condition: true
is encoded by: hsa:6487
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: ST3GAL3
constant: false

metaM 5mthf e
type: Species
initial amount: NaN
initial concentration: 1.0
name: 5-Methyltetrahydrofolate
has only substance units: false
notes: FORMULA: C20H24N7O6 CHARGE: -1
is: SBO:0000247
is: C00440
constant: false
is: HMDB01396
boundary condition: false
is: CHEBI:3729

metaR RE2541E
name: RE2541
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.2.1.31
modifier: MODEL1310110023#
reversible: true
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
fast: false

metaR DURAD2
name: dihydrothymin dehydrogenase (NADP)
fast: false
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.3.1.2
modifier: MODEL1310110023#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
kinetic law: MODEL1310110023#
product: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_1edba86b_c0d5_45d7_8a00_a4dbc2483cc7
has only substance units: false
is: Q86TM7
constant: false
initial concentration: NaN
is encoded by: hsa:54344
name: DPM3
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252

metaM g3m8mpdol U r
initial concentration: 1.0
boundary condition: false
constant: false
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
notes: FORMULA: C1905H3140N20O770P20 CHARGE: -20
is: C05873
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN

metaR 4NPHSULT
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Cytochrome metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.8.2.1
kinetic law: MODEL1310110023#
reversible: false
modifier: MODEL1310110023#
reactant: MODEL1310110023#
fast: false
is: SBO:0000176
is described by: ECO:0000269
name: 4-Nitrophenol Sulfotransferase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_b4dca90b_67db_4bdc_b657_55813c5604c6
name: GCNT4
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:51301
has only substance units: false
type: Species
boundary condition: true
is: Q9P109

http://identifiers.org/biomodels.db/MODEL1310110023#_a7b3ce67_8a76_4e39_a7dc_82bf32c8111d
constant: false
has part: Q5VYT2
is encoded by: hsa:4731
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4712
has only substance units: false
type: Species
is: SBO:0000297
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
initial amount: NaN

metaR PHCDm
reversible: false
is described by: ECO:0000304
is: SBO:0000176
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464,PMID:500817 NOTES:NCD
modifier: MODEL1310110023#
name: L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase
is version of: http://identifiers.org/ec-code/1.5.1.12
product: MODEL1310110023#
reactant: MODEL1310110023#
fast: false
type: Reaction
kinetic law: MODEL1310110023#

metaM 2octpencoa m
constant: false
initial amount: NaN
has only substance units: false
is: HMDB02288
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
type: Species
name: 2,6,9,12,15-octadecapentenoylcoa
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110023#_f54e8856_347b_4095_9258_e12e2efce00d
type: Species
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:27306
name: HPGDS
is: O60760

metaR IZPN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
name: Imidazolonepropionase
type: Reaction
product: MODEL1310110023#
fast: false
reversible: false
is described by: ECO:0000000

metaR r0932
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
type: Reaction
is: SBO:0000185
product: MODEL1310110023#
is described by: ECO:0000000
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
name: Transport reaction

metaR HXPRT
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.8
fast: false
reversible: false
product: MODEL1310110023#
name: hypoxanthine phosphoribosyltransferase (Hypoxanthine)
is: SBO:0000176
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine (see GUAPRT) and 6-mercaptopurine can replace hypoxanthine
is described by: ECO:0000269
modifier: MODEL1310110023#
reactant: MODEL1310110023#

metaR S6T12g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110023#
fast: false
type: Reaction
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (23563.1) or (9435.1) or (10164.1) or (4166.1) or (23563.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110023#
kinetic law: MODEL1310110023#
is described by: ECO:0000000
modifier: MODEL1310110023#

metaM hdca l
name: palmitate
has only substance units: false
type: Species
is: HMDB00220
constant: false
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
initial amount: NaN
initial concentration: 1.0
is: CHEBI:7896
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110023#_5615c796_c987_4050_89ed_8a631f2c3dd5
is: B2RB47
name: AMPD2
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:271
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_fb0876b9_bd57_4342_9f10_c087dd7c5475
is encoded by: hsa:5294
is encoded by: hsa:10870
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000297
initial amount: NaN
has part: Q9UBK5
has part: P48736
type: Species
name: HCST:PIK3CG

http://identifiers.org/biomodels.db/MODEL1310110023#_bae85e1b_2e95_454f_ac37_8e9036e55957
type: Species
is: SBO:0000252
boundary condition: true
is: Q7GXY9
has only substance units: false
constant: false
name: ND2
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4536

metaM ascb L c
has only substance units: false
name: L-ascorbate
is: CHEBI:38290
initial amount: NaN
is: HMDB00044
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
is: SBO:0000247

metaR UGCG
modifier: MODEL1310110023#
name: Ceramide glucosyltransferase
is described by: ECO:0000000
reactant: MODEL1310110023#
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.4.1.80
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (7357.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES:NJ
fast: false
is: SBO:0000176
kinetic law: MODEL1310110023#

metaM pac c
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
name: phenylacetate
initial concentration: 1.0
constant: false
is: CHEBI:18401
type: Species
is: SBO:0000247
is: HMDB00209
has only substance units: false
boundary condition: false
initial amount: NaN

metaM fru e
initial concentration: 1.0
is: SBO:0000247
is: C00095
is: HMDB00660
type: Species
is: CHEBI:15824
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
name: D-Fructose
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false

metaM CE4794 m
has only substance units: false
constant: false
name: cis-6-dodecenoyl-CoA
initial concentration: 1.0
is: CHEBI:57923
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,20-22,26-28,32,43-44H,4-7,10-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE4794
is: SBO:0000247

metaM urate e
type: Species
is: CHEBI:17775
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB00289
initial concentration: 1.0
name: Urate
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
is: C00366

metaR AKGtp
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
kinetic law: MODEL1310110023#
is described by: ECO:0000000
reactant: MODEL1310110023#
type: Reaction
name: AKG transporter, peroxisome
product: MODEL1310110023#
is: SBO:0000185
fast: false

metaR ILEt5m
reversible: true
fast: false
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
is: SBO:0000185
name: Isoleucine mitochondrial transport
is described by: ECO:0000000
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
type: Reaction

metaM lneldccoa m
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
name: linoelaidyl coenzyme A
notes: FORMULA: C39H62N7O17P3S CHARGE: -4
is: HMDB01064
has only substance units: false
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5462164

metaM ksii core2 pre3 g
notes: FORMULA: C47H76N4O33X CHARGE: -1
initial amount: NaN
is: CHEBI:58053
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 3
type: Species
is: HMDB00175
is: C00130
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247

metaR r0360
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
reversible: false
reactant: MODEL1310110023#
is: SBO:0000176
product: MODEL1310110023#
type: Reaction
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.16
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#

metaR KHK2
type: Reaction
product: MODEL1310110023#
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.1.3
is described by: ECO:0000269
is: SBO:0000176
reversible: false
name: ketohexokinase (D-xylulose)
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 2.7.1.3 Confidence Level: 4 AUTHORS: PMID:2996495,PMID:6284103,PMID:6298387 NOTES:NCD
fast: false

metaM HC02202 e
type: Species
is: CHEBI:57398
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: prostaglandin A1(1-)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110023#_74f49ba2_0e29_4be0_8071_2ee3c5fe4b23
is: SBO:0000297
has only substance units: false
type: Species
is encoded by: hsa:3030
initial amount: NaN
name: HADHA:HADHB
initial concentration: NaN
has part: P55084
is encoded by: hsa:3032
constant: false
boundary condition: true
has part: E9KL44

metaR r1078
name: Vesicular transport
kinetic law: MODEL1310110023#
type: Reaction
reactant: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000185
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110023#

metaR ESTRADIOLt
fast: false
type: Reaction
kinetic law: MODEL1310110023#
is described by: ECO:0000000
name: estradiol transport
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110023#
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_55d6e73a_46e2_405d_88b6_dcb9c55d3421
initial concentration: NaN
constant: false
is encoded by: hsa:4329
name: ALDH6A1
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
is: Q02252

http://identifiers.org/biomodels.db/MODEL1310110023#_9f8a6147_349f_404c_b13d_8b6fa8277441
constant: false
name: _H53099_1_m
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:H53099
initial concentration: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_61f97a7d_1c2e_4a0b_b9e9_d74d33da165b
name: NDUFS3
has only substance units: false
is encoded by: hsa:4722
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
is: O75489
type: Species

metaM Ser Thr l
is: CHEBI:58190
has only substance units: false
is: SBO:0000247
type: Species
name: protein-linked serine or threonine residue (O-glycosylation site)
initial concentration: 1.0
constant: false
notes: FORMULA: XH CHARGE: 0
initial amount: NaN
is: HMDB00224
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110023#_645120ce_ea06_46a3_9ab6_94f43be1daee
boundary condition: true
is: P09669
constant: false
is encoded by: hsa:1345
initial amount: NaN
name: COX6C
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_074848a1_6ff2_4a4f_8623_cddeba06b4d3
is: SBO:0000252
type: Species
initial amount: NaN
name: PIK3C2B
is: O00750
is encoded by: hsa:5287
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110023#_6c8f5e79_1f09_4eba_89a4_e54f042b25e2
boundary condition: true
is encoded by: hsa:7298
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: P04818
name: TYMS

metaR 5ADTSTSTERONEte
product: MODEL1310110023#
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110023#
name: 5 alpha dihydrotesterone transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
kinetic law: MODEL1310110023#
is: SBO:0000185
reversible: true

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_860e4b01_4748_4eec_9279_9523bb63f2e5
constant: false
is: O95045
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:151531
name: UPP2

metaM leuktrF4 c
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
boundary condition: false
is: SBO:0000247
name: leukotriene F4
is: HMDB06465
initial amount: NaN
is: CHEBI:27491
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_beba0fd1_aee5_4812_b8f6_04d00e18db72
name: OCRL
type: Species
initial concentration: NaN
initial amount: NaN
is: Q01968
is encoded by: hsa:4952
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR r0937
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110023#
reversible: true
fast: false
name: Transport reaction
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_6682168d_2e1f_478c_87e1_da54e1ab9889
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4728
initial amount: NaN
type: Species
has only substance units: false
is: O00217
name: NDUFS8
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_63a45693_cc82_4db2_b2c7_3db08155a0d5
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:197257
initial concentration: NaN
name: LDHD
is: SBO:0000252
type: Species
boundary condition: true
is: Q86WU2

metaM hs deg24 l
notes: FORMULA: C31H50NO26 CHARGE: -1
type: Species
has only substance units: false
is: CHEBI:16126
initial amount: NaN
boundary condition: false
name: GlcNAc-GlcA-(Gal)2-Xyl
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR ADRNCOAtx
is described by: ECO:0000000
kinetic law: MODEL1310110023#
reversible: true
reactant: MODEL1310110023#
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110023#
name: fatty acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

http://identifiers.org/biomodels.db/MODEL1310110023#_e623617e_4f05_4495_a450_fcc4e8d924cb
is: Q5MY95
is encoded by: hsa:377841
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
name: ENTPD8
constant: false
is: SBO:0000252

metaR RE3000M
notes: GENE_ASSOCIATION: (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is: SBO:0000176
reversible: true
name: RE3000
kinetic law: MODEL1310110023#
fast: false
modifier: MODEL1310110023#
reactant: MODEL1310110023#
product: MODEL1310110023#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_61978e3c_04f0_412a_a1ba_6e7df16f9cb5
is encoded by: hsa:2271
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
is: P07954
initial amount: NaN
has only substance units: false
name: FH
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110023#_833c52f1_afc9_4038_b65a_7475789ac6db
is encoded by: hsa:5152
has only substance units: false
type: Species
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
name: PDE9A
is: SBO:0000252

metaR H6ET3er
is version of: http://identifiers.org/ec-code/2.7.8.1
product: MODEL1310110023#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (84720.2) and (5281.1) or (84720.1) and (5281.2) or (5281.1) and (84720.1) or (84720.2) and (5281.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10781593,PMID:8463218 NOTES:NCD
kinetic law: MODEL1310110023#
fast: false
reactant: MODEL1310110023#
reversible: false
is described by: ECO:0000000
name: H6 phosphoethanolaminyl transferase, endoplasmic reticulum

metaR VALLAT1tc
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Valine by LAT1 in association with 4F2hc, across the apical surface of the memebranes.
type: Reaction

metaR r2130
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
product: MODEL1310110023#
is described by: ECO:0000000
reactant: MODEL1310110023#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110023#

metaM acald m
constant: false
is: CHEBI:15343
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
type: Species
has only substance units: false
is: HMDB00990
name: acetaldehyde
boundary condition: false

metaR r0936
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
product: MODEL1310110023#
fast: false
is described by: ECO:0000000
name: Transport reaction
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
reversible: false

metaM ksi pre12 g
notes: FORMULA: C135H218N9O106S3X CHARGE: -4
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
is: C00130
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 12
is: CHEBI:58053
is: SBO:0000247
constant: false

metaM orn m
initial amount: NaN
has only substance units: false
is: CHEBI:46912
is: SBO:0000247
type: Species
name: Ornithine
constant: false
is: HMDB00214
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: C01602
boundary condition: false
initial concentration: 1.0

metaM 3hpp m
constant: false
initial amount: NaN
is: SBO:0000247
is: HMDB00700
has only substance units: false
name: 3-hydroxypropionate
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
boundary condition: false
is: CHEBI:16510
initial concentration: 1.0
type: Species

metaM udpglcur r
constant: false
type: Species
has only substance units: false
name: UDP-D-glucuronate
is: CHEBI:58052
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
is: SBO:0000247
is: C00167
initial amount: NaN
boundary condition: false
is: HMDB00935
initial concentration: 1.0

metaM pristcoa x
initial concentration: 1.0
is: CHEBI:51341
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
name: pristanoyl coa
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247

metaR r0627
is: SBO:0000176
product: MODEL1310110023#
is described by: ECO:0000000
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_9bc6b01a_003f_4596_9934_8f117a11a1d3
type: Species
boundary condition: true
name: _H17063_1_c
is encoded by: hsa:H17063
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false

metaR ALCD21 D
fast: false
notes: GENE_ASSOCIATION: (127.1) or (284273.2) or (125.1) or (128.1) or (131.1) or (125.1 and 124.1) or (124.1) or (130.1) or (137872.1) or (125.1 and 126.1) or (126.1 and 124.1) or (284273.1) or (126.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
reversible: false
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.1.99.24
reactant: MODEL1310110023#
is: SBO:0000176
product: MODEL1310110023#
is described by: ECO:0000304
type: Reaction
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.1.1.1
name: alcohol dehydrogenase (D-1,2-propanediol)

metaM lnlccrn c
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
is: SBO:0000247
is: HMDB06469
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
name: Linoleyl carnitine
type: Species
initial concentration: 1.0

metaR GLCt1r
product: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: (66035.1) or (6517.1) or (56606.1) or (154091.1) or (6513.1) or (11182.1) or (29988.1) or (6514.1) or (155184.1) or (56606.2) or (144195.1) or (6515.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860667,PMID:10860996,PMID:10970791,PMID:11247674,PMID:11583593,PMID:11592815,PMID:11780753,PMID:11832379,PMID:11882499,PMID:12135767,PMID:12483288,PMID:12504846,PMID:12750891,PMID:12914765,PMID:14739288,PMID:15033637,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110023#
modifier: MODEL1310110023#
is: SBO:0000185
name: glucose transport (uniport)
kinetic law: MODEL1310110023#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_b6b59a42_b976_4f5c_8309_1b9457248836
is encoded by: hsa:5151
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
name: PDE8A
is: SBO:0000252
initial amount: NaN
is: O60658
type: Species

metaR CYTK7n
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP,UTP),nuclear
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110023#
is: SBO:0000176
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
product: MODEL1310110023#
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_07037108_a36b_4ace_bc3c_9375705010f1
is encoded by: hsa:5634
has only substance units: false
name: PRPS2
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
is: P11908
constant: false

metaR EX orn LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ornithine exchange
type: Reaction

metaR DOPASFt
reactant: MODEL1310110023#
name: Dopamine 3-0-sulfate transport (diffusion)
kinetic law: MODEL1310110023#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110023#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of dopamine sulfate
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_ba44a57f_4cd0_47e4_a137_7f815798f3a2
is: SBO:0000252
type: Species
is: P22392
initial amount: NaN
initial concentration: NaN
name: NME2
is encoded by: hsa:4831
boundary condition: true
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_03a29292_a87c_4229_8dad_e09f9ab1fa20
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: AK2
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:204

metaR KCCt
modifier: MODEL1310110023#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110023#
product: MODEL1310110023#
type: Reaction
reactant: MODEL1310110023#
is described by: ECO:0000269
name: K+-Cl- cotransport
reversible: true
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD

metaR r1746
type: Reaction
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
fast: false
reactant: MODEL1310110023#
is described by: ECO:0000000
kinetic law: MODEL1310110023#
product: MODEL1310110023#
modifier: MODEL1310110023#

metaR EX dcsptn1 LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: docosa-4,7,10,13,16-pentaenoic acid (n-6) exchange
type: Reaction

metaR GASNASE2ly
reversible: false
type: Reaction
reactant: MODEL1310110023#
fast: false
name: glycosylasparaginase, lysosomal
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.26
is described by: ECO:0000000
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_186bef62_e4fc_421f_8950_6e7513751f0f
initial concentration: NaN
is: SBO:0000252
constant: false
is: Q96C36
name: PYCR2
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:29920

metaM 5mthf c
is: SBO:0000247
initial amount: NaN
is: CHEBI:3729
constant: false
has only substance units: false
is: HMDB01396
notes: FORMULA: C20H24N7O6 CHARGE: -1
name: 5-Methyltetrahydrofolate
initial concentration: 1.0
type: Species
is: C00440
boundary condition: false

metaR GTHO
is described by: ECO:0000254
type: Reaction
is version of: http://identifiers.org/ec-code/1.8.1.7
reactant: MODEL1310110023#
is: SBO:0000176
product: MODEL1310110023#
name: glutathione oxidoreductase
fast: false
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
reversible: false
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#

metaR r0774
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110023#
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
fast: false
product: MODEL1310110023#
reversible: true

metaR AG13T11g
kinetic law: MODEL1310110023#
product: MODEL1310110023#
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110023#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false

metaR r0669
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110023#
reversible: false
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110023#_16f9b01b_26dd_47ec_a552_536edd12ac1b
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: MPI
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:4351
type: Species
is: P34949

metaM 2decdicoa m
is: http://identifiers.org/pubchem.compound/16019966
type: Species
initial amount: NaN
is: SBO:0000247
name: 2,7-decadienoylcoa
initial concentration: 1.0
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
boundary condition: false
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_fd778a24_1ec1_4e75_81e0_ab26ef67ca42
initial amount: NaN
has only substance units: false
is encoded by: hsa:6526
initial concentration: NaN
type: Species
name: SLC5A3
is: SBO:0000252
boundary condition: true
constant: false
is: P53794

metaM 2octdectecoa x
name: 2,6,9,12-octadecatetraenoylcoa
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
is: HMDB02288
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR RE1709N
reversible: true
reactant: MODEL1310110023#
modifier: MODEL1310110023#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/4.2.1.96
fast: false
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
product: MODEL1310110023#
name: RE1709
is: SBO:0000176

metaR FUMm
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/4.2.1.2
reactant: MODEL1310110023#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
product: MODEL1310110023#
fast: false
type: Reaction
name: fumarase, mitochondrial
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: PMID:16774737,PMID:17111171,PMID:17111172 NOTES:IF. Biochemical

metaM galacglcgalgluside hs g
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:17103
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
name: Lc4Cer

metaR GTHP
fast: false
kinetic law: MODEL1310110023#
name: glutathione peroxidase
is version of: http://identifiers.org/ec-code/1.11.1.15
reactant: MODEL1310110023#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
reversible: true
modifier: MODEL1310110023#
product: MODEL1310110023#
type: Reaction
is version of: http://identifiers.org/ec-code/1.11.1.9
is version of: http://identifiers.org/ec-code/1.11.1.12
is: SBO:0000176

metaM tym c
notes: FORMULA: C8H12NO CHARGE: 1 INCHI: InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2/p+1 EHMN_ABBREVIATION: C00483
initial amount: NaN
initial concentration: 1.0
is: HMDB00306
has only substance units: false
boundary condition: false
name: tyraminium
constant: false
type: Species
is: CHEBI:327995
is: SBO:0000247

metaM glyc R c
initial concentration: 1.0
is: HMDB00139
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
name: D-glycerate
has only substance units: false
is: CHEBI:16659
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_8cef2c48_706d_4740_9995_bc69504c502b
initial concentration: NaN
is encoded by: hsa:3295
is: SBO:0000252
name: HSD17B4
is: E9PB82
boundary condition: true
initial amount: NaN
constant: false
type: Species
has only substance units: false

metaM HC10852 r
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h9-10,24-26,30-32,36,47-48H,4-8,11-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b10-9-/t26-,30-,31-,32+,36-/m1/s1 EHMN_ABBREVIATION: CE0852
has only substance units: false
is: SBO:0000247
type: Species
name: palmitoleyl-CoA(4-)
is: CHEBI:61540
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaM mpdol U c
notes: FORMULA: C1245H2040N20O220P20 CHARGE: -20
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:18396
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human uterine homolog
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_db61d75c_a8f8_41ab_a808_d42166cb91c3
constant: false
has only substance units: false
boundary condition: true
name: FOLR1
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
is: P15328
is encoded by: hsa:2348

metaR SO4OXAtex2
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
type: Reaction
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
product: MODEL1310110023#
fast: false
name: sulfate transport via oxalate countertransport (2:1)
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110023#_d29e0fe8_608e_42f9_b56c_475ca8a49fec
constant: false
initial amount: NaN
is encoded by: hsa:11041
is: SBO:0000252
name: B3GNT1
initial concentration: NaN
is: O43505
type: Species
has only substance units: false
boundary condition: true

metaR r0629
modifier: MODEL1310110023#
reversible: true
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.1.4.1
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.6.1.22
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
kinetic law: MODEL1310110023#

metaM CE2434 m
is: SBO:0000247
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
has only substance units: false
is: CHEBI:57795
type: Species
constant: false
initial amount: NaN

metaR ENGASE3ly
fast: false
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000000
name: endo-beta-N-acetylglucosaminidase, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110023#
type: Reaction
reversible: false

metaR r2346
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110023#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110023#
reactant: MODEL1310110023#
fast: false

metaM glcur r
has only substance units: false
constant: false
type: Species
name: D-glucuronate
initial concentration: 1.0
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: SBO:0000247
is: HMDB00127
is: CHEBI:15748
boundary condition: false
initial amount: NaN

metaR 4MPTNLtm
is: SBO:0000185
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:8428987 NOTES:
kinetic law: MODEL1310110023#
product: MODEL1310110023#
type: Reaction
name: 4-methylpentanal transport (mitochondria)
reactant: MODEL1310110023#

metaM 6pgc r
initial amount: NaN
notes: FORMULA: C6H10O10P CHARGE: -3 INCHI: InChI=1S/C6H13O10P/c7-2(1-16-17(13,14)15)3(8)4(9)5(10)6(11)12/h2-5,7-10H,1H2,(H,11,12)(H2,13,14,15)/p-3/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00292 EHMN_ABBREVIATION: C00345
boundary condition: false
name: 6-phosphonatooxy-D-gluconate
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:58759
is: HMDB01316
initial concentration: 1.0
constant: false

metaM decdp c
has only substance units: false
is: SBO:0000247
name: all trans Decaprenyl diphosphate
type: Species
is: HMDB06288
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C50H81O7P2 CHARGE: -3 INCHI: InChI=1/C50H90O7P2/c1-41(2)21-31-53-58(51,54-32-22-42(3)4)57-59(52,35-25-45(9)10,36-26-46(11)12,37-27-47(13)14,38-28-48(15)16,39-29-49(17)18,40-30-50(19)20,55-33-23-43(5)6)56-34-24-44(7)8/h21-30H,31-40H2,1-20H3

metaM ksi deg14 l
notes: FORMULA: C166H267N11O145S8 CHARGE: -8
is: SBO:0000247
is: HMDB00143
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:12936
boundary condition: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 14
constant: false

metaR r2347
kinetic law: MODEL1310110023#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110023#
name: Organic anion transporter 5 Utilized transport
reversible: true
is: SBO:0000185
product: MODEL1310110023#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_a7e95e21_8e81_45e6_82cf_57d12011a2ed
initial amount: NaN
is encoded by: hsa:8879
is: O95470
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
name: SGPL1
constant: false
is: SBO:0000252

metaR PI4P3K
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.11.1
product: MODEL1310110023#
reversible: false
kinetic law: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5296.1 and 5290.1) or (5293.1 and 5296.1) or (5287.1) or (5286.1) or (5293.1 and 8503.1) or (5293.1 and 5295.3) or (5291.1 and 8503.1) or (5295.2 and 5290.1) or (5288.1) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (23533.1 and 5294.1) or (5293.1 and 5295.1) or (5295.2 and 5293.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (10870.1 and 5294.1) or (5295.2 and 5291.1) or (5290.1 and 5295.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD Notice that contrary to some standards in texts, KEGG, etc, the Rtotal group accounts for the whole fatty acyl CoA (so the CHO only accounts for the core backbone), manner in which Rtotal was produced accounts for O and H balances. Formation of the Rtotal group (rxn flux)accounted for mass balance for CoA NJ changed EC from 2.7.1.149 (pail5p) to 2.7.1.68 (pail4p) - NCD
is version of: http://identifiers.org/ec-code/2.7.1.153
name: phosphatidylinositol 4-phosphate 3-kinase
is: SBO:0000176
is described by: ECO:0000000
fast: false
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.1.154

metaM HC02216 e
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
has only substance units: false
boundary condition: false
is: CHEBI:28922
initial amount: NaN
name: prostaglandin-f2beta

metaR THP2Ctp
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate transport, peroxisomal
type: Reaction
product: MODEL1310110023#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110023#
reversible: true
reactant: MODEL1310110023#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:MM

metaM chsterol r
boundary condition: false
has only substance units: false
constant: false
is: HMDB00067
name: cholesterol
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
initial amount: NaN
is: CHEBI:16113
is: SBO:0000247
type: Species
initial concentration: 1.0

metaM hdca c
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: HMDB00220
initial concentration: 1.0
type: Species
constant: false
name: palmitate
is: SBO:0000247
boundary condition: false
is: CHEBI:7896
has only substance units: false
initial amount: NaN

metaR r1886
reversible: false
fast: false
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110023#
product: MODEL1310110023#

metaR FAOXC61m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)m
type: Reaction

metaR ANTHte
type: Reaction
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
is: SBO:0000185
reversible: true
name: Transport of anthranilate
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110023#

metaR NDPK2n
reversible: true
name: nucleoside-diphosphate kinase (ATP:UDP), nuclear
fast: false
modifier: MODEL1310110023#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110023#
is described by: ECO:0000269
product: MODEL1310110023#

metaR EX fald LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of formaldehyde
type: Reaction

metaR r2110
product: MODEL1310110023#
type: Reaction
modifier: MODEL1310110023#
is: SBO:0000185
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR S6T8g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
reactant: MODEL1310110023#
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110023#
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#

metaR CEPTE
notes: GENE_ASSOCIATION: (10390.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: ethanolamine phosphotransferase
is: SBO:0000176
type: Reaction
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.8.2
is described by: ECO:0000269
reversible: false
product: MODEL1310110023#
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
fast: false

metaR r0202
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110023#
is: SBO:0000176
product: MODEL1310110023#
type: Reaction
is described by: ECO:0000000
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8

metaM mi13p c
is: SBO:0000247
is: CHEBI:18225
is: HMDB06234
boundary condition: false
constant: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)5(17-19(11,12)13)4(10)6(3(1)9)18-20(14,15)16/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3+,4+,5+,6-
initial concentration: 1.0
initial amount: NaN
name: 1D-myo-Inositol 1,3-bisphosphate
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_da3c5378_ffb4_4e3a_8b61_f1b287c72465
boundary condition: true
name: DECR1
type: Species
has only substance units: false
is: Q16698
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:1666
is: SBO:0000252

metaM hdca e
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: C00249
notes: FORMULA: C16H31O2 CHARGE: -1
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
name: Hexadecanoate (n-C16:0)
is: CHEBI:0
is: HMDB00220

metaM mi1p D c
name: 1D-myo-inositol 1-phosphate(2-)
is: SBO:0000247
type: Species
is: CHEBI:58433
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
constant: false
is: HMDB02985
has only substance units: false
initial amount: NaN

metaR r0074
is version of: http://identifiers.org/ec-code/6.2.1.1
kinetic law: MODEL1310110023#
fast: false
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110023#
reversible: true
reactant: MODEL1310110023#
product: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:

metaR KSIt
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110023#
reversible: false
reactant: MODEL1310110023#
is described by: ECO:0000000
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: keratan sulfate I transport, golgi to extracellular

http://identifiers.org/biomodels.db/MODEL1310110023#_7824239c_d8f8_4650_b725_4952e47bb67c
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:84889
is: Q8WY07
name: SLC7A3
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110023#_1c13fa4c_6ad0_4902_b868_2fbf202c9c52
initial amount: NaN
constant: false
type: Species
boundary condition: true
name: GALNT11
is: SBO:0000252
has only substance units: false
is encoded by: hsa:63917
initial concentration: NaN
is: B3KWF4

metaR r2111
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110023#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
type: Reaction
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false

metaM asn L m
name: L-asparagine
is: HMDB00168
is: SBO:0000247
type: Species
is: CHEBI:17196
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaM gam c
is: CHEBI:17315
constant: false
initial concentration: 1.0
boundary condition: false
is: C00329
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
type: Species
name: D-Glucosamine
initial amount: NaN
is: HMDB01514
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_dcd6b6f8_3ef4_42a6_9707_b92d0cde5ba8
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: B7Z792
name: NDUFS2
constant: false
is encoded by: hsa:4720
has only substance units: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110023#_ccdc261e_6b0a_4946_a879_f04e547b5209
is: SBO:0000252
has only substance units: false
name: PYCRL
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:65263
boundary condition: true
is: Q53H96

metaR DESAT22 2p
fast: false
is described by: ECO:0000000
name: fatty acyl-CoA desaturase (n-C22:5CoA -> n-C22:6CoA)
type: Reaction
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110023#_6934b69f_5663_4e73_8576_ad31479dc3db
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:292
name: SLC25A5
is: Q6NVC0
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false

metaR r2112
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
kinetic law: MODEL1310110023#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110023#
is described by: ECO:0000000
modifier: MODEL1310110023#
product: MODEL1310110023#

metaM h2o r
is: SBO:0000247
constant: false
initial concentration: 1.0
name: H2O
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
has only substance units: false
initial amount: NaN
is: HMDB02111
type: Species
boundary condition: false
is: C00001
is: CHEBI:15377

metaM focytC m
constant: false
is: SBO:0000247
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
name: Ferrocytochrome C
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:16928
initial concentration: 1.0
has only substance units: false

metaM lnlc c
initial amount: NaN
constant: false
type: Species
name: linoleate
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
has only substance units: false
is: HMDB00673
is: CHEBI:30245
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR PPAm
type: Reaction
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.6.1.1
fast: false
is: SBO:0000176
kinetic law: MODEL1310110023#
reversible: false
modifier: MODEL1310110023#
is described by: ECO:0000269
name: inorganic diphosphatase
product: MODEL1310110023#

metaR HPYRR2x
name: hydroxypyruvate reductase (NADH)
type: Reaction
kinetic law: MODEL1310110023#
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.1.2.4
modifier: MODEL1310110023#
is: SBO:0000176
reactant: MODEL1310110023#
is described by: ECO:0000304
fast: false
notes: GENE_ASSOCIATION: (3948.1) or (197257.1) or (3945.1) or (160287.1) or (3945.1 and 3939.1) or (92483.1) or (3939.1) or (197257.2) or (3948.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:14635115,PMID:5635456 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.1.27
reversible: false

metaR DNDPt33m
modifier: MODEL1310110023#
fast: false
is described by: ECO:0000269
reversible: false
name: dGDP transport via dUDP antiport
type: Reaction
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110023#
is: SBO:0000185
kinetic law: MODEL1310110023#

metaM accoa x
is: SBO:0000247
name: Acetyl-CoA
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB01206
initial amount: NaN
is: CHEBI:57288
has only substance units: false
is: C00024
type: Species
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024

metaM 3hmbcoa m
initial amount: NaN
is: HMDB01356
initial concentration: 1.0
type: Species
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
is: SBO:0000247
constant: false
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
is: CHEBI:57312
boundary condition: false
has only substance units: false

metaR FAOXC123C102m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:3-->C10:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_8721931f_4d37_4b0f_941f_b4e12b39816c
constant: false
is encoded by: hsa:2990
boundary condition: true
has only substance units: false
name: GUSB
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
is: P08236

metaR r1302
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
kinetic law: MODEL1310110023#
type: Reaction
reversible: true
is: SBO:0000185
name: Vesicular transport
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000000

metaM 25aics c
constant: false
initial amount: NaN
is: CHEBI:58443
boundary condition: false
is: HMDB00797
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
initial concentration: 1.0
is: SBO:0000247
type: Species
is: C04823
has only substance units: false
notes: FORMULA: C13H15N4O12P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01356 EHMN_ABBREVIATION: C04823

http://identifiers.org/biomodels.db/MODEL1310110023#_960190c2_2a9d_4358_a083_ff720bbb8dca
has only substance units: false
type: Species
initial amount: NaN
is: P35557
boundary condition: true
constant: false
initial concentration: NaN
name: GCK
is encoded by: hsa:2645
is: SBO:0000252

metaR r0208
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
reversible: true
fast: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110023#
is described by: ECO:0000000
product: MODEL1310110023#
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13
is version of: http://identifiers.org/ec-code/4.4.1.1

metaM ca2 c
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: calcium(2+)
initial amount: NaN
is: HMDB00464
boundary condition: false
type: Species
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
is: CHEBI:29108
constant: false

metaR r2113
reversible: true
product: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110023#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110023#
type: Reaction

metaM lnlccrn m
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB06469
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
name: Linoleyl carnitine
constant: false
initial amount: NaN
boundary condition: false

metaM srtn c
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB00259
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
name: serotonin(1+)
is: CHEBI:350546
type: Species
initial amount: NaN

metaR r0931
fast: false
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110023#
kinetic law: MODEL1310110023#
name: Transport reaction
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_324d1924_2475_4629_bfb3_c3cfe60e39de
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
name: GBA
constant: false
initial concentration: NaN
is: P04062
is encoded by: hsa:2629
initial amount: NaN

metaR RE3568C
name: RE3568
type: Reaction
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
product: MODEL1310110023#
fast: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reversible: true

metaM HC01104 e
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
name: 4-nitrophenyl phosphate(2-)
is: CHEBI:61146
initial concentration: 1.0
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360

metaR r0780
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
reactant: MODEL1310110023#
is: SBO:0000176
fast: false
reversible: true
type: Reaction
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
is described by: ECO:0000000
product: MODEL1310110023#

metaM ipdp c
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:128769
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H9O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
is: HMDB01347
name: Isopentenyl diphosphate
is: C00129

metaR ALCD21 L
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.1.1.1
is version of: http://identifiers.org/ec-code/1.1.99.24
is described by: ECO:0000304
is: SBO:0000176
notes: GENE_ASSOCIATION: (130.1) or (125.1) or (125.1 and 124.1) or (128.1) or (126.1) or (284273.2) or (137872.1) or (127.1) or (124.1) or (126.1 and 124.1) or (284273.1) or (125.1 and 126.1) or (131.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
type: Reaction
modifier: MODEL1310110023#
fast: false
product: MODEL1310110023#
reversible: false
name: alcohol dehydrogenase (L-1,2-propanediol)

metaR MAN6PI
is version of: http://identifiers.org/ec-code/5.3.1.8
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
name: mannose-6-phosphate isomerase
is: SBO:0000176
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
reversible: true
is described by: ECO:0000304
modifier: MODEL1310110023#
type: Reaction
fast: false

metaR AHCYStd
type: Reaction
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:
kinetic law: MODEL1310110023#
fast: false
product: MODEL1310110023#
is described by: ECO:0000134
name: diffusion of S-Adenosyl-L-homocysteine
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110023#_86978582_4f5c_49ed_8f61_41b57dc4d8fe
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6482
type: Species
name: ST3GAL1

metaR r2114
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110023#
is described by: ECO:0000000
kinetic law: MODEL1310110023#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110023#
is: SBO:0000185
product: MODEL1310110023#
type: Reaction

metaM leuktrD4 c
initial concentration: 1.0
is: CHEBI:28666
is: HMDB03080
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
is: SBO:0000247
boundary condition: false
type: Species
name: Leukotriene D4
constant: false
has only substance units: false
initial amount: NaN

metaM chsterol m
name: cholesterol
type: Species
is: HMDB00067
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
is: CHEBI:16113

metaR NADS2
is described by: ECO:0000269
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
name: NAD synthase (glutamine-hydrolysing)
type: Reaction
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/6.3.5.1
notes: GENE_ASSOCIATION: (55191.1) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110023#
product: MODEL1310110023#
fast: false

metaM lnlc e
has only substance units: false
is: HMDB00673
is: SBO:0000247
name: linoleate
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
constant: false
type: Species
boundary condition: false
is: CHEBI:30245
initial amount: NaN
initial concentration: 1.0

metaR HPYRRy
is version of: http://identifiers.org/ec-code/1.1.1.79
modifier: MODEL1310110023#
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110023#
reversible: false
product: MODEL1310110023#
kinetic law: MODEL1310110023#
type: Reaction
fast: false
name: Hydroxypyruvate reductase (NADPH)
notes: GENE_ASSOCIATION: (9380.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.79 Confidence Level: 4 AUTHORS: PMID:2689175,PMID:9038835 NOTES:JLR

http://identifiers.org/biomodels.db/MODEL1310110023#_294aa109_7cef_48f1_aaf2_5e33b3f2bb8b
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:5142
boundary condition: true
name: PDE4B
is: Q5TEK5
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_bcf4314a_ba7f_4210_a76b_c80a00d2fc22
initial concentration: NaN
boundary condition: true
name: _R14373_1_x
initial amount: NaN
constant: false
is encoded by: hsa:R14373
has only substance units: false
is: SBO:0000252
type: Species

metaR FAOXC122m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)m
type: Reaction

metaR r0781
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/1.1.1.35
name: Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) Biosynthesis of steroids EC:1.14.13.70
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.107
reversible: true
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.13.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
fast: false

metaM glcur l
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
boundary condition: false
is: HMDB00127
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15748
has only substance units: false
type: Species
constant: false
name: D-glucuronate
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110023#_407d65a2_f4de_4a86_b3d4_271d0a09fad4
has only substance units: false
name: IMPDH2
constant: false
initial concentration: NaN
is: P12268
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:3615
type: Species

metaM chsterol l
initial amount: NaN
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:16113
name: cholesterol
is: HMDB00067
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110023#_326f0cbf_569d_4eeb_ba1d_95d9280597fe
type: Species
initial amount: NaN
constant: false
name: NOS1
is encoded by: hsa:4842
has only substance units: false
is: B4DG68
is: SBO:0000252
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110023#_7fb26513_b5c9_4d9b_8e56_3a57a7572209
initial amount: NaN
has part: Q86U05
initial concentration: NaN
constant: false
is encoded by: hsa:23428
is: SBO:0000297
type: Species
boundary condition: true
has only substance units: false
name: SLC7A8:SLC3A2

metaM srtn e
is: HMDB00259
is: CHEBI:350546
initial concentration: 1.0
type: Species
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
name: serotonin(1+)
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false

metaR r2115
is described by: ECO:0000000
reversible: true
is: SBO:0000185
product: MODEL1310110023#
fast: false
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM ca2 e
is: SBO:0000247
initial amount: NaN
is: HMDB00464
has only substance units: false
initial concentration: 1.0
name: calcium(2+)
boundary condition: false
type: Species
constant: false
is: CHEBI:29108
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076

metaR NDP7g
modifier: MODEL1310110023#
name: nucleoside-diphosphatase (UDP), Golgi apparatus
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD
is: SBO:0000176
type: Reaction
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.6.1.6
fast: false
reversible: false
is described by: ECO:0000269

metaR PPAn
product: MODEL1310110023#
is described by: ECO:0000000
name: inorganic diphosphatase, nuclear
is: SBO:0000176
reactant: MODEL1310110023#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: 3.6.1.1 Confidence Level: 1 AUTHORS: NOTES:
kinetic law: MODEL1310110023#
reversible: false

metaR RTOTALt
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
name: RTOTAL transport
reversible: true
product: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:

metaM gcald c
initial amount: NaN
constant: false
is: HMDB03344
name: glycolaldehyde
has only substance units: false
is: CHEBI:17071
initial concentration: 1.0
type: Species
notes: FORMULA: C2H4O2 CHARGE: 0 INCHI: InChI=1S/C2H4O2/c3-1-2-4/h1,4H,2H2 EHMN_ABBREVIATION: C00266
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110023#_f9be0341_019f_4fb0_bc82_471c6c5a8e33
boundary condition: true
initial amount: NaN
is encoded by: hsa:175
has only substance units: false
is: P20933
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
name: AGA

metaR 4MPTNLte
type: Reaction
reversible: true
reactant: MODEL1310110023#
product: MODEL1310110023#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8428987 NOTES:
is described by: ECO:0000000
name: 4-methylpentanal transport
kinetic law: MODEL1310110023#

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_491da7cc_cbc6_418c_a2f3_6de6058857bc
initial amount: NaN
boundary condition: true
type: Species
constant: false
has only substance units: false
name: HK2
is: P52789
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3099

metaM h2o n
is: CHEBI:15377
type: Species
is: SBO:0000247
is: HMDB02111
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial concentration: 1.0
name: water

metaM orn c
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: Ornithine
constant: false
is: CHEBI:0
is: SBO:0000247
type: Species
is: HMDB00214
boundary condition: false
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: C01602

http://identifiers.org/biomodels.db/MODEL1310110023#_e68ad8d7_421b_4bc7_9cc9_1bc7689b8262
has only substance units: false
type: Species
name: PDE9A
is: SBO:0000252
constant: false
is encoded by: hsa:5152
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR r2116
product: MODEL1310110023#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110023#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110023#
type: Reaction
reversible: true
kinetic law: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_b5aaf2d6_65c3_418e_8cf6_469f86ebf75b
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:376497
constant: false
name: SLC27A1
has only substance units: false

metaR ALDD2xm
reactant: MODEL1310110023#
name: aldehyde dehydrogenase (acetylaldehyde, NAD), mitochondrial
product: MODEL1310110023#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (219.1) or (217.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:18983992,PMID:18983993,PMID:19382904,PMID:19382905 NOTES:NCD. For NAD
fast: false
modifier: MODEL1310110023#
is described by: ECO:0000134

metaR EX 7dhf LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (DHF) exchange
type: Reaction

metaR GTHPm
is version of: http://identifiers.org/ec-code/1.11.1.12
name: glutathione peroxidase, mitochondria
is version of: http://identifiers.org/ec-code/1.11.1.15
kinetic law: MODEL1310110023#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110023#
modifier: MODEL1310110023#
fast: false
reversible: true
product: MODEL1310110023#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)

metaM 13dampp c
has only substance units: false
initial concentration: 1.0
type: Species
name: trimethylenediaminium
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:57484
is: HMDB00002
notes: FORMULA: C3H12N2 CHARGE: 2 INCHI: InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2/p+2 EHMN_ABBREVIATION: C00986

metaR FE2DMT1
reactant: MODEL1310110023#
name: uptake of food iron by DMT1 transporter
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (4891.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
reversible: false
product: MODEL1310110023#
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000134

metaM cs e deg2 l
boundary condition: false
is: CHEBI:57455
initial amount: NaN
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
type: Species
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 2
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01354
has only substance units: false

metaM ppi c
boundary condition: false
is: HMDB00250
type: Species
is: CHEBI:0
is: SBO:0000247
has only substance units: false
constant: false
name: Diphosphate
initial amount: NaN
notes: FORMULA: HO7P2 CHARGE: -3
is: C00013
initial concentration: 1.0

metaM h2o m
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
boundary condition: false
name: H2O
is: C00001
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:15377
constant: false
is: HMDB02111

metaM g2m8masn r
has only substance units: false
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C82H137N2O65X CHARGE: 0
initial amount: NaN
is: C05874

metaR 5ADTSTSTERONEtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
kinetic law: MODEL1310110023#
is: SBO:0000185
name: 5 alpha dihydrotesterone intracellular transport
type: Reaction
fast: false
product: MODEL1310110023#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_1a7cd650_8a67_48ee_937c_36613f522ec0
initial concentration: NaN
initial amount: NaN
is: Q8TDB8
type: Species
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:144195
name: SLC2A14

metaM sphgn c
name: sphinganine(1+)
is: CHEBI:57817
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
initial amount: NaN
type: Species
is: HMDB00269
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false

metaM tag hs e
is: SBO:0000247
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
is: CHEBI:17855
type: Species
name: triglyceride
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaR r2117
kinetic law: MODEL1310110023#
is described by: ECO:0000000
product: MODEL1310110023#
is: SBO:0000185
modifier: MODEL1310110023#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110023#
fast: false

metaM lys L x
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:32551
type: Species
name: L-lysinium(1+)
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: HMDB00182

metaR DOPAtu
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110023#
reversible: true
reactant: MODEL1310110023#
type: Reaction
name: Dopamine uniport
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
product: MODEL1310110023#
modifier: MODEL1310110023#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110023#_aff26890_e59f_4a69_9354_d6d97f5b95f5
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

metaR r1454
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
reactant: MODEL1310110023#
name: TCDB:2.A.1.13.5 TCDB:2.A.1.13.1
reversible: false
is: SBO:0000185
product: MODEL1310110023#
kinetic law: MODEL1310110023#
is described by: ECO:0000000
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_cf46d5b5_e4b8_4804_9360_09f649087973
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:501
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
constant: false
name: ALDH7A1
is: E7EPT3

http://identifiers.org/biomodels.db/MODEL1310110023#_9f71e57c_cde6_4635_a4f9_23bd22e1f524
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: P54819
name: AK2
type: Species
initial amount: NaN
is encoded by: hsa:204

http://identifiers.org/biomodels.db/MODEL1310110023#_cfa8a4e6_c8ba_4a2b_a15a_b1c3ee6fcc66
type: Species
boundary condition: true
is: SBO:0000252
name: HADH
is encoded by: hsa:3033
is: Q16836
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_38a072ff_840a_4b7c_9301_66f6e70baf86
name: ST3GAL3
initial concentration: NaN
is encoded by: hsa:6487
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
constant: false
boundary condition: true

metaR UAG4E
type: Reaction
is described by: ECO:0000304
reversible: true
kinetic law: MODEL1310110023#
fast: false
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/5.1.3.2
reactant: MODEL1310110023#
name: UDP-N-acetylglucosamine 4-epimerase
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110023#_94d76298_0a69_496d_b7a1_00331611d720
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
is: B3KXY9
name: HK1
is encoded by: hsa:3098
constant: false
has only substance units: false

metaM h2o l
constant: false
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial amount: NaN
is: CHEBI:15377
type: Species
boundary condition: false
is: HMDB02111
initial concentration: 1.0
name: water
has only substance units: false
is: SBO:0000247

metaR r2118
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reversible: true
is: SBO:0000185
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#

metaM gam e
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB01514
type: Species
name: D-Glucosamine
initial amount: NaN
is: C00329
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
boundary condition: false
is: CHEBI:17315

metaM ppi e
initial amount: NaN
is: CHEBI:33019
name: Diphosphate
is: HMDB00250
is: C00013
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR r0671
is version of: http://identifiers.org/ec-code/3.2.1.22
modifier: MODEL1310110023#
reversible: false
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (2717.1) or (6173.1) SUBSYSTEM: CoA synthesis EC Number: 6.3.2.5 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:12906824,PMID:15893380 NOTES:
is: SBO:0000176
fast: false
name: (R)-4-Phosphopantothenate:L-cysteine ligase EC:6.3.2.5

metaR FERO
fast: false
kinetic law: MODEL1310110023#
is: SBO:0000176
product: MODEL1310110023#
is described by: ECO:0000134
reversible: false
notes: GENE_ASSOCIATION: (9843.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
name: ferroxidase
modifier: MODEL1310110023#
reactant: MODEL1310110023#
type: Reaction

metaR r1453
fast: false
is: SBO:0000176
reactant: MODEL1310110023#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
product: MODEL1310110023#
kinetic law: MODEL1310110023#
type: Reaction
reversible: true
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8

http://identifiers.org/biomodels.db/MODEL1310110023#_cfa6bc1a_50db_4e14_8055_13f2ecb1605e
constant: false
has only substance units: false
is encoded by: hsa:9498
type: Species
name: SLC4A8
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: E7EML0

metaR r2341
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
reversible: true
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110023#

metaM accoa m
boundary condition: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: SBO:0000247
has only substance units: false
is: C00024
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57288
is: HMDB01206
type: Species
name: Acetyl-CoA
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_7976b72c_e665_415d_a329_796782831fa0
type: Species
constant: false
is: Q8TCD5
initial concentration: NaN
name: NT5C
is encoded by: hsa:30833
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR GALASE6ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110023#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
is: SBO:0000176
name: beta-galactosidase, lysosomal
modifier: MODEL1310110023#
is described by: ECO:0000000
reactant: MODEL1310110023#

metaM tag hs c
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
name: triglyceride
is: CHEBI:17855
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN

metaR SPHS1Ptr
is described by: ECO:0000000
name: sphingosine-1-phosphate transport
reversible: true
reactant: MODEL1310110023#
product: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414 or PMID: 15585321). NJ
is: SBO:0000185
kinetic law: MODEL1310110023#
fast: false

metaM s2l2n2m2m l
is: HMDB02177
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C84H136N6O62 CHARGE: -2
is: CHEBI:36033
has only substance units: false
initial amount: NaN
boundary condition: false
name: de-Fuc form of PA6 (w/o peptide linkage)
constant: false

metaR r0672
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.181 Confidence Level: 0 AUTHORS: PMID:12679481 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.65
reversible: true
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
is: SBO:0000176
product: MODEL1310110023#
name: Cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase Bile acid biosynthesis EC:1.1.1.181
modifier: MODEL1310110023#

metaR URCN
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/4.2.1.49
notes: GENE_ASSOCIATION: (131669.1) SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
type: Reaction
reversible: false
product: MODEL1310110023#
name: URCN

metaM accoa n
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
name: acetyl-CoA(4-)
is: HMDB01206
constant: false
initial concentration: 1.0
is: CHEBI:57288
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_42945d6a_69eb_4859_99c2_922fcbe7d653
is: SBO:0000252
is: Q8IW54
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:5138
name: PDE2A

http://identifiers.org/biomodels.db/MODEL1310110023#_7cafb32f_07de_4bd1_858e_674441e6b810
type: Species
is encoded by: hsa:7264
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: Q13630
name: TSTA3

metaR 3SALACBOXL
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.15
notes: GENE_ASSOCIATION: (51380.1) or (2571.1) or (2572.1) or (2571.2) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 4.1.1.15 Confidence Level: 4 AUTHORS: NOTES:SAB
is version of: http://identifiers.org/ec-code/4.1.1.29
is described by: ECO:0000269
name: 3-Sulfino-L-alanine carboxy-lyase
modifier: MODEL1310110023#
product: MODEL1310110023#
type: Reaction
reactant: MODEL1310110023#
reversible: false
fast: false
kinetic law: MODEL1310110023#

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_556b6bde_c173_481f_92f5_abbf5a75c30e
boundary condition: true
is encoded by: hsa:2639
name: GCDH
initial amount: NaN
constant: false
is: Q92947
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species

metaR NAGA2ly
name: N-acetylgalactosaminidase, alpha-
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.2.1.49
product: MODEL1310110023#
is described by: ECO:0000000
type: Reaction
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
modifier: MODEL1310110023#
fast: false

metaM dudp n
initial concentration: 1.0
is: HMDB01000
is: CHEBI:60471
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
boundary condition: false
constant: false
name: dUDP(3-)

metaR G6PDH1rer
is version of: http://identifiers.org/ec-code/1.1.1.47
product: MODEL1310110023#
is: SBO:0000176
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:tv, jp NCD
fast: false
reactant: MODEL1310110023#
modifier: MODEL1310110023#
type: Reaction
kinetic law: MODEL1310110023#
reversible: true
name: glucose-6-phosphate dehydrogenase, endoplasmic reticulum
is described by: ECO:0000269

metaM adn c
is: CHEBI:16335
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
is: C00212
boundary condition: false
name: Adenosine
is: HMDB00050
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species

metaM cit c
has only substance units: false
initial amount: NaN
is: HMDB00094
is: SBO:0000247
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: CHEBI:16947
constant: false
name: Citrate
type: Species
initial concentration: 1.0
is: C00158
boundary condition: false

metaR CSPG Etly
type: Reaction
name: chondroitin sulfate E transport, extracellular to lysosome
reactant: MODEL1310110023#
is: SBO:0000185
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110023#

metaM asn L e
is: CHEBI:17196
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB00168
boundary condition: false
type: Species
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
name: L-asparagine
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110023#_e94a9844_d7f6_440b_96dd_7651ffbfe960
has part: P12074
has part: Q6FGA0
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
has part: Q8TF08
initial amount: NaN
has part: P24310
is encoded by: hsa:4512
is encoded by: hsa:4514
is encoded by: hsa:1339
has part: Q6YFQ2
is: SBO:0000297
is encoded by: hsa:1349
is encoded by: hsa:1327
has part: P00414
is encoded by: hsa:9167
has part: P14854
is encoded by: hsa:1340
has part: P20674
constant: false
has part: H0UI06
is encoded by: hsa:170712
has part: P13073
is encoded by: hsa:1337
has part: Q53XN1
has part: Q7GXY8
boundary condition: true
is encoded by: hsa:1346
is encoded by: hsa:341947
is encoded by: hsa:1329
type: Species
is encoded by: hsa:4513
is encoded by: hsa:125965
initial concentration: NaN
is encoded by: hsa:1351
has part: Q96KJ9
has part: P24311
is encoded by: hsa:84701
has part: P15954
has only substance units: false
has part: P09669
has part: Q02221
is encoded by: hsa:1345
is encoded by: hsa:1347
is encoded by: hsa:1350
is encoded by: hsa:9377
has part: Q53YB7
has part: Q7GXZ8
has part: Q7Z4L0

http://identifiers.org/biomodels.db/MODEL1310110023#_4fe5a45e_39c2_441d_b05c_c77d780ff20f
has only substance units: false
constant: false
is: Q13123
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: IK
type: Species
is encoded by: hsa:3550
initial amount: NaN

metaR GULN3D
product: MODEL1310110023#
reversible: true
fast: false
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
type: Reaction
name: L-gulonate 3-dehydrogenase
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD

metaR L LACt4r
is described by: ECO:0000000
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
reversible: true
reactant: MODEL1310110023#
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110023#
name: L-lactate reversible transport via sodium symport

metaR r2000
is: SBO:0000185
reversible: false
product: MODEL1310110023#
modifier: MODEL1310110023#
type: Reaction
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_15c6063c_d3b9_4814_bfab_e6db1e62798d
constant: false
type: Species
has only substance units: false
boundary condition: true
has part: E7EX19
is encoded by: hsa:5295
initial concentration: NaN
name: PIK3CD:PIK3R1
is: SBO:0000297
initial amount: NaN

metaR RETNt
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110023#
reversible: true
reactant: MODEL1310110023#
name: retinoic acid transport
type: Reaction
fast: false

metaR PPAt
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8135845 NOTES:TDV
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
is: SBO:0000185
name: Propionate transport, diffusion
type: Reaction
product: MODEL1310110023#
reversible: false

metaM ksi deg36 l
boundary condition: false
name: keratan sulfate I, degradation product 36
is: CHEBI:12936
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB00143
has only substance units: false
notes: FORMULA: C62H103N4O49S1 CHARGE: -1
constant: false
initial concentration: 1.0

metaM dump c
has only substance units: false
constant: false
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
name: dUMP
initial concentration: 1.0
is: C00365
is: CHEBI:246422
type: Species
is: HMDB01409
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaR DMHPTCRNt
kinetic law: MODEL1310110023#
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 1 AUTHORS: NOTES:dmhptcoa is 'special' because its biochemical fat isn't known NJ
name: 2,6 dimethylheptanoyl crn transport
is: SBO:0000185
reactant: MODEL1310110023#
product: MODEL1310110023#
reversible: true

metaM dudp m
constant: false
name: dUDP(3-)
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB01000
type: Species
is: CHEBI:60471
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346

metaM HC01162 c
constant: false
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:58376
initial concentration: 1.0
type: Species
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
initial amount: NaN

metaM hpdcacoa m
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
name: heptadecanoyl coa
boundary condition: false
has only substance units: false
is: HMDB06497

metaR CYTD
kinetic law: MODEL1310110023#
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.5.4.5
reversible: false
notes: GENE_ASSOCIATION: (978.1) or (57379.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.5 Confidence Level: 2 AUTHORS: PMID:14744791,PMID:15087440,PMID:7923172,PMID:8001985,PMID:8422236 NOTES:
is: SBO:0000176
fast: false
modifier: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000254
name: cytidine deaminase
type: Reaction

metaM glyc R m
constant: false
boundary condition: false
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
is: SBO:0000247
initial concentration: 1.0
name: D-glycerate
is: HMDB00139
is: CHEBI:16659
has only substance units: false
type: Species
initial amount: NaN

metaR r2344
is: SBO:0000185
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
product: MODEL1310110023#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_473594b3_1162_4911_a3f4_2b75ad376fb4
is encoded by: hsa:4258
name: MGST2
constant: false
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: D6RBB5
has only substance units: false
initial concentration: NaN

metaR CYSGLNNaEx
is: SBO:0000185
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
kinetic law: MODEL1310110023#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110023#
reactant: MODEL1310110023#
name: L-cysteine/L-glutamine Na-dependent exchange (Cys-L in)
fast: false

metaM adn e
is: CHEBI:16335
initial concentration: 1.0
is: C00212
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
boundary condition: false
constant: false
is: HMDB00050
is: SBO:0000247
name: Adenosine
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_0ef74c0d_587c_4098_95ef_d096b870b87a
is encoded by: hsa:286297
boundary condition: true
is: SBO:0000252
type: Species
name: _286297_1_c
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN

metaM asn L c
is: HMDB00168
initial concentration: 1.0
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
name: L-asparagine
type: Species
is: CHEBI:17196
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false

metaM cit e
name: citrate(3-)
type: Species
boundary condition: false
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: SBO:0000247
is: HMDB00094
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16947
constant: false

metaM h2o g
is: CHEBI:15377
initial amount: NaN
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: HMDB02111
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
type: Species
name: water

metaR SBTD D2
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110023#
product: MODEL1310110023#
reversible: false
fast: false
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.1.1.14
notes: GENE_ASSOCIATION: (6652.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.14 Confidence Level: 0 AUTHORS: PMID:14965227 NOTES:NCD
kinetic law: MODEL1310110023#
name: D-sorbitol dehydrogenase (D-fructose producing)
type: Reaction

metaM leuleu c
name: Leucylleucine
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C12H24N2O3 CHARGE: 0
boundary condition: false
type: Species
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/94244

metaR FUMSO4tm
is: SBO:0000185
reversible: true
reactant: MODEL1310110023#
type: Reaction
product: MODEL1310110023#
fast: false
name: Fumarate:sulfate antiport, mitochondrial
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#

metaM HC02216 c
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
initial amount: NaN
constant: false
name: prostaglandin-f2beta
is: CHEBI:28922
has only substance units: false
type: Species
initial concentration: 1.0

metaM dolp U c
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57683
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
name: dolichyl phosphate(2-)
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false

metaR S3TASE1ly
type: Reaction
product: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000176
fast: false
name: N-acetylglucosamine-3-sulfatase, lysosomal
reactant: MODEL1310110023#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110023#

metaR DUDPtn
fast: false
kinetic law: MODEL1310110023#
product: MODEL1310110023#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: dUDP nuclear transport
is: SBO:0000185

metaM tdchola x
name: taurochenodeoxycholate
type: Species
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:9407
is: HMDB00951
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465

metaR GALSGLT1le
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of D-Galactose from extracellular space to cytosol of mucosal cells in small intestine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_d66a946c_056c_40e2_8bb0_1b84465e4dbb
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
type: Species
is encoded by: hsa:1384
initial amount: NaN
name: CRAT

http://identifiers.org/biomodels.db/MODEL1310110023#_855e4742_4641_4e61_a04e_d2fce9883a24
initial amount: NaN
name: SGMS1
boundary condition: true
is encoded by: hsa:259230
is: D3DWC4
has only substance units: false
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN

metaM accoa c
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:57288
initial concentration: 1.0
initial amount: NaN
is: C00024
constant: false
is: HMDB01206
boundary condition: false
name: Acetyl-CoA

metaM HC02023 r
name: Cholesterol-ester-ol
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:46898
notes: FORMULA: C45H78O2 CHARGE: 0 INCHI: InChI=1S/C45H78O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h14-15,26,35-36,38-42H,7-13,16-25,27-34H2,1-6H3/b15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110023#_3974cb56_812b_4f48_98f6_c6b4c93adc33
type: Species
boundary condition: true
is encoded by: hsa:AI480132
name: _AI480132_1_c
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_c4a1cdcb_0285_44a1_a15c_406a0fd16e47
has only substance units: false
is: O14521
type: Species
is encoded by: hsa:6392
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
name: SDHD
boundary condition: true

metaM 2docopencoa x
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
name: 2,7,10,13,16-docosapentenoylcoa
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
is: HMDB02288
is: SBO:0000247

metaR RE0577C
kinetic law: MODEL1310110023#
is described by: ECO:0000000
product: MODEL1310110023#
reactant: MODEL1310110023#
fast: false
type: Reaction
name: RE0577
is: SBO:0000176
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.65
is version of: http://identifiers.org/ec-code/3.1.2.2
reversible: true

metaR r1459
product: MODEL1310110023#
reversible: true
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000185
name: Transport reaction

metaM apoC Lys c
name: Apocarboxylase (Lys residue)
initial amount: NaN
is: CHEBI:32551
is: SBO:0000247
constant: false
is: HMDB00182
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C6H13N2OX CHARGE: 0
boundary condition: false

metaM 5aop c
is: C00430
initial concentration: 1.0
has only substance units: false
is: HMDB01149
initial amount: NaN
boundary condition: false
name: 5-Amino-4-oxopentanoate
type: Species
is: CHEBI:17549
is: SBO:0000247
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
constant: false

metaM 4nphsf e
is: HMDB06492
constant: false
is: SBO:0000247
is: CHEBI:35422
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
type: Species
has only substance units: false
name: 4-Nitrophenyl sulfate

http://identifiers.org/biomodels.db/MODEL1310110023#_c8fafc86_0ccd_4055_a777_c6cecf9226ab
is encoded by: hsa:483
constant: false
has part: B7Z3U6
boundary condition: true
initial amount: NaN
name: ATP1A1:ATP1B3
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000297
has part: P54709
is encoded by: hsa:476

http://identifiers.org/biomodels.db/MODEL1310110023#_cb4bd422_533a_4486_90b3_b71932ceccfa
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: P34896
type: Species
is encoded by: hsa:6470
constant: false
name: SHMT1

http://identifiers.org/biomodels.db/MODEL1310110023#_a79fc53f_4220_499d_996b_5181b8a6a106
is encoded by: hsa:80025
constant: false
boundary condition: true
is: Q9BZ23
name: PANK2
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR ACGAMtly
name: N-acetyl-glucosamine lysosomal efflux
product: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000185
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
type: Reaction

metaR BDHm
modifier: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000269
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.30
kinetic law: MODEL1310110023#
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
fast: false
is: SBO:0000176
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_801a473d_256f_4fa8_8fdb_1aff3bd1c7a6
boundary condition: true
type: Species
is: SBO:0000252
name: DLAT
is: Q86YI5
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1737
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_e32ac5f1_613f_45ab_a01e_1dd5d96f7bd5
type: Species
name: PANK2
has only substance units: false
is: Q6P1K9
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:80025
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_10157308_6de9_40be_a909_47f8d7a0de16
type: Species
name: TMEM91
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
is: C9JZ62
initial amount: NaN
constant: false
is encoded by: hsa:641649

metaM Sfglutth c
is: CHEBI:57688
is: SBO:0000247
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
constant: false
initial amount: NaN
is: HMDB01550
name: S-formylglutathionate(1-)
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110023#_dea07957_a077_4fc3_b0e2_2cb3dd0f1657
boundary condition: true
constant: false
type: Species
is encoded by: hsa:1595
is: Q16850
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: CYP51A1

metaM dcsptn1 e
is: HMDB13123
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5282848
name: docosa-4,7,10,13,16-pentaenoic acid
initial amount: NaN

metaR PAPStg
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
fast: false
is: SBO:0000185
modifier: MODEL1310110023#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
product: MODEL1310110023#
name: 3'-Phosphoadenylyl sufate Golgi transport
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_728ab2c8_93be_4bd9_b603_a003d462c003
is: H0UI06
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: COX7A2
type: Species
is encoded by: hsa:1347

metaR CRVNCtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
product: MODEL1310110023#
type: Reaction
reactant: MODEL1310110023#
name: fatty acid transport via diffusion
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110023#

metaR NDPK2
fast: false
kinetic law: MODEL1310110023#
is described by: ECO:0000269
name: nucleoside-diphosphate kinase (ATP:UDP)
notes: GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110023#
modifier: MODEL1310110023#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110023#_7942062c_23ea_4e30_a449_98fd2b9105bb
name: ACO1
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:48
boundary condition: true
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: P21399

metaM 3hmp m
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
type: Species
is: HMDB00023
constant: false
name: 3-hydroxy-2-methylpropanoate
is: SBO:0000247
is: CHEBI:11805
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaR FUCACGALFUCGALACGLCGALGLUSIDEte
fast: false
reversible: true
product: MODEL1310110023#
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
name: blood group intracellular transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
is described by: ECO:0000000
is: SBO:0000185

metaM lys L m
initial amount: NaN
has only substance units: false
is: CHEBI:32551
is: SBO:0000247
is: HMDB00182
constant: false
boundary condition: false
name: L-lysinium(1+)
initial concentration: 1.0
type: Species
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047

http://identifiers.org/biomodels.db/MODEL1310110023#_71c86390_82f4_4f7f_be32_5a8e7cb8c45f
constant: false
is: P21589
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4907
initial concentration: NaN
boundary condition: true
name: NT5E
has only substance units: false
type: Species

metaM hpdcacoa c
name: heptadecanoyl coa
is: SBO:0000247
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
is: HMDB06497
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_8d12234e_3826_4db5_903b_f0d6c539600b
is: O43820
boundary condition: true
initial amount: NaN
type: Species
name: HYAL3
is encoded by: hsa:8372
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252

metaM 4nphsf c
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
initial concentration: 1.0
type: Species
is: CHEBI:35422
is: HMDB06492
initial amount: NaN
name: 4-Nitrophenyl sulfate
constant: false
boundary condition: false

metaR r0355
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
product: MODEL1310110023#
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.3
is: SBO:0000176
type: Reaction
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
fast: false
is described by: ECO:0000000

metaM HC01406 m
name: 3-Oxooctanoyl-CoA
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
constant: false
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267
initial concentration: 1.0
boundary condition: false
is: CHEBI:28264

metaM dolglcp U r
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
is: CHEBI:15812
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog
initial amount: NaN
has only substance units: false
constant: false

metaM dhor S c
name: (S)-dihydroorotate
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C5H5N2O4 CHARGE: -1 INCHI: InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00285
constant: false
is: HMDB03349
initial amount: NaN
is: CHEBI:30864
boundary condition: false

metaR P450SCC1m
fast: false
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
name: cholesterol monooxygenase
product: MODEL1310110023#
kinetic law: MODEL1310110023#
type: Reaction
reversible: true

metaR NDPK1
is described by: ECO:0000134
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
type: Reaction
reversible: true
name: nucleoside-diphosphate kinase (ATP:GDP)
notes: GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110023#
fast: false
is: SBO:0000176

metaR AMPtp
product: MODEL1310110023#
is described by: ECO:0000000
reactant: MODEL1310110023#
type: Reaction
kinetic law: MODEL1310110023#
fast: false
reversible: true
name: AMP transporter, peroxisome
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ

metaR r0679
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110023#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
reversible: true
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
type: Reaction
modifier: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_7073e80e_5f6a_46ea_b2a7_7fd8534ad82e
name: SLC35D1
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is: Q9NTN3
is encoded by: hsa:23169

http://identifiers.org/biomodels.db/MODEL1310110023#_9deac47d_6f16_4fec_8d3c_d94dd11d964e
is encoded by: hsa:955
constant: false
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
name: ENTPD6
is: O75354
initial amount: NaN
has only substance units: false

metaM dump n
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
is: CHEBI:246422
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB01409
name: dUMP(2-)
has only substance units: false

metaR TRIODTHYt2
fast: false
reversible: true
modifier: MODEL1310110023#
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
is: SBO:0000185
product: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
name: T3 transport via facilitated diffusion
is described by: ECO:0000269

metaR r0354
is: SBO:0000176
type: Reaction
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
fast: false
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/6.2.1.3

metaR NDPK4
kinetic law: MODEL1310110023#
name: nucleoside-diphosphate kinase (ATP:dTDP)
modifier: MODEL1310110023#
product: MODEL1310110023#
fast: false
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction

metaR ALAt4
reversible: false
is: SBO:0000185
fast: false
name: Alanine-Sodium symporter
is described by: ECO:0000269
modifier: MODEL1310110023#
product: MODEL1310110023#
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (54407.1) or (6542.1) or (11254.1) or (6541.1) or (81539.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:tv Mendz pg. 201 Reversibility is unclear.
reactant: MODEL1310110023#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_89cd222e_2c4d_4c2b_aad4_76d73b0bcb74
boundary condition: true
name: PIK3CA:PIK3R2
initial amount: NaN
is encoded by: hsa:5290
constant: false
is encoded by: hsa:5296
has part: P42336
has part: O00459
type: Species
is: SBO:0000297
initial concentration: NaN
has only substance units: false

metaR NRPPHRSULT
type: Reaction
fast: false
is described by: ECO:0000269
product: MODEL1310110023#
is: SBO:0000176
reactant: MODEL1310110023#
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
name: Norepinephrine Sulfotransferase
notes: GENE_ASSOCIATION: (6818.1) or (6818.3) or (6818.2) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
reversible: false
is version of: http://identifiers.org/ec-code/2.8.2.1

metaM thbpt4acam c
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
is: CHEBI:15374
has only substance units: false
is: HMDB02281
boundary condition: false
name: 4a-hydroxytetrahydrobiopterin
is: SBO:0000247

metaR B3GNT51g
notes: GENE_ASSOCIATION: (84002.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110023#
product: MODEL1310110023#
is described by: ECO:0000304
reversible: false
modifier: MODEL1310110023#
is: SBO:0000176
reactant: MODEL1310110023#
type: Reaction
fast: false
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5

http://identifiers.org/biomodels.db/MODEL1310110023#_47543562_bd0c_4728_8a7f_185d2fd97172
boundary condition: true
constant: false
is encoded by: hsa:80201
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is: B3KT70
name: HKDC1

metaM dcsptn1 c
name: docosa-4,7,10,13,16-pentaenoic acid
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB13123
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5282848
constant: false
boundary condition: false
type: Species

metaR B3GNT39g
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
reactant: MODEL1310110023#
modifier: MODEL1310110023#
product: MODEL1310110023#
is: SBO:0000176
kinetic law: MODEL1310110023#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
is described by: ECO:0000000

metaM accoa g
has only substance units: false
is: HMDB01206
type: Species
initial amount: NaN
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: CHEBI:57288
constant: false
is: SBO:0000247
boundary condition: false
name: acetyl-CoA(4-)
initial concentration: 1.0

metaR r0630
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
is version of: http://identifiers.org/ec-code/3.1.3.1
modifier: MODEL1310110023#
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
is: SBO:0000176
fast: false
is described by: ECO:0000000
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.2
product: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_75b96cc1_238d_4b9a_9c13_0ca6f14026fe
is encoded by: hsa:AI285872
type: Species
boundary condition: true
initial amount: NaN
name: _AI285872_1_c
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN

metaR NDPK3
product: MODEL1310110023#
fast: false
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:CDP)
reactant: MODEL1310110023#
modifier: MODEL1310110023#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110023#

metaM gln L c
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: L-glutamine
is: CHEBI:18050
initial amount: NaN
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: HMDB00641
boundary condition: false

metaR EX oxa LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Oxalate exchange
type: Reaction

metaR EX gmp LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_0805dbf5_8be9_4ecd_9b9d_e6cb4cc27e4b
is encoded by: hsa:7360
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
name: UGP2

http://identifiers.org/biomodels.db/MODEL1310110023#_0814e9fb_4cc8_480d_859c_76644b5ed999
is encoded by: hsa:129642
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: Q6ZWT7
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: MBOAT2

http://identifiers.org/biomodels.db/MODEL1310110023#_d63025c3_4b2c_4ea5_a744_4eb5f04e7349
is encoded by: hsa:36
is: P45954
initial concentration: NaN
name: ACADSB
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
type: Species

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

metaR CYSGLUexR
name: L-cysteine/L-glutamine reversible exchanger
is described by: ECO:0000304
product: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
modifier: MODEL1310110023#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110023#_24bffeca_3cfb_4e51_b802_accd5584bcd4
name: ALG3
constant: false
is: SBO:0000252
is encoded by: hsa:10195
initial amount: NaN
is: Q92685
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR NDPK6
name: Nucleoside-diphosphate kinase (ATP:dUDP)
fast: false
kinetic law: MODEL1310110023#
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110023#
modifier: MODEL1310110023#
reversible: true
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110023#_8b25994e_6699_4df5_b6b4_0424344f8dbb
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
constant: false
name: EPX
initial concentration: NaN
is encoded by: hsa:8288
is: P11678
has only substance units: false

metaR FAOXC2252053m
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - c22:5,n-3 -> c20:5, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
kinetic law: MODEL1310110023#
name: Beta oxidation of long chain fatty acid
modifier: MODEL1310110023#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
is described by: ECO:0000000
product: MODEL1310110023#
reversible: false

metaM leuktrD4 r
has only substance units: false
constant: false
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
is: SBO:0000247
initial amount: NaN
name: Leukotriene D4
initial concentration: 1.0
is: HMDB03080
type: Species
boundary condition: false
is: CHEBI:28666

metaM L2aadp m
type: Species
is: HMDB00510
name: L-2-aminoadipate(1-)
initial concentration: 1.0
has only substance units: false
is: CHEBI:58672
constant: false
boundary condition: false
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
is: SBO:0000247
initial amount: NaN

metaM 20ahchsterol m
initial concentration: 1.0
is: CHEBI:1296
boundary condition: false
name: 20-hydroxycholesterol
constant: false
is: SBO:0000247
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500
has only substance units: false
initial amount: NaN
is: HMDB06283
type: Species

metaR SPHS1Pte
product: MODEL1310110023#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110023#
type: Reaction
name: sphingosine-1-phosphate transport
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_3278e590_78d0_48f7_943c_48ef88928300
is: Q86VQ6
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
name: TXNRD3
is encoded by: hsa:114112
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_49433abc_59dc_4c4d_9103_6ce0555d8431
constant: false
is encoded by: hsa:6818
boundary condition: true
type: Species
is: SBO:0000252
name: SULT1A3
initial amount: NaN
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_96698325_f1cb_4d14_a30b_9f7414074115
boundary condition: true
type: Species
is: SBO:0000252
name: ALDH9A1
initial amount: NaN
has only substance units: false
constant: false
is: P49189
initial concentration: NaN
is encoded by: hsa:223

metaR XYLtly
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110023#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
name: Xylose efflux from lysosome
product: MODEL1310110023#
reversible: false
reactant: MODEL1310110023#

metaM ocdca c
is: HMDB00827
initial amount: NaN
type: Species
name: stearate
initial concentration: 1.0
is: CHEBI:25629
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530

metaR NDPK7
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110023#
is described by: ECO:0000269
modifier: MODEL1310110023#
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:dCDP)
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110023#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110023#_50b0a06c_807d_42ae_bc30_046c9cbb60ac
constant: false
is: SBO:0000252
type: Species
boundary condition: true
name: IDH1
initial amount: NaN
has only substance units: false
is encoded by: hsa:3417
initial concentration: NaN
is: O75874

metaM ksi deg30 l
notes: FORMULA: C90H147N6O75S3 CHARGE: -3
initial amount: NaN
is: SBO:0000247
type: Species
name: keratan sulfate I, degradation product 30
initial concentration: 1.0
is: HMDB00143
is: CHEBI:12936
boundary condition: false
constant: false
has only substance units: false

metaR FRUt4
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
modifier: MODEL1310110023#
reactant: MODEL1310110023#
fast: false
kinetic law: MODEL1310110023#
is: SBO:0000185
type: Reaction
name: D-fructose transport via sodium cotransport
is described by: ECO:0000269
product: MODEL1310110023#
reversible: true

metaR NDPK5
type: Reaction
fast: false
name: Nucleoside-diphosphate kinase (ATP:dGDP)
kinetic law: MODEL1310110023#
is described by: ECO:0000269
product: MODEL1310110023#
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
modifier: MODEL1310110023#
reversible: true

metaM trdox c
is: CHEBI:18191
constant: false
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
is: SBO:0000247
initial amount: NaN
name: Oxidized thioredoxin
is: C00343

metaM ksi deg2 l
has only substance units: false
name: keratan sulfate I, degradation product 2
type: Species
notes: FORMULA: C241H384N17O210S12 CHARGE: -13
is: HMDB02177
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:36033

metaM gln L e
has only substance units: false
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
constant: false
is: CHEBI:18050
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
name: L-glutamine
is: HMDB00641

http://identifiers.org/biomodels.db/MODEL1310110023#_ab1d5215_4c16_4f6a_b2c6_6de2ef32f306
boundary condition: true
initial concentration: NaN
constant: false
name: PRDX1
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:5052
is: SBO:0000252

metaR PHACCOAGLNAC
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110023#
product: MODEL1310110023#
name: Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
is: SBO:0000176
reactant: MODEL1310110023#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 2.3.1.14 Confidence Level: 2 AUTHORS: NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110023#_3e255bc1_da64_4f9a_a417_ddf4b232ff14
is: SBO:0000252
constant: false
is encoded by: hsa:6517
is: P14672
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: SLC2A4
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110023#_3544d216_307b_408b_84df_cb149e4bac38
is: Q9Y672
name: ALG6
initial amount: NaN
is encoded by: hsa:29929
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_19d6462c_5090_41fd_8fc4_827123b38490
is: Q969I6
name: SLC38A4
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:55089
initial concentration: NaN

metaR LEUKTRD4tr
product: MODEL1310110023#
name: leukotriene intracellular transport
reactant: MODEL1310110023#
fast: false
type: Reaction
kinetic law: MODEL1310110023#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ

metaR NDPK9
fast: false
is described by: ECO:0000269
type: Reaction
product: MODEL1310110023#
name: nucleoside-diphosphate kinase (ATP:IDP)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
reactant: MODEL1310110023#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110023#_0306ef78_d5db_4949_aa75_11dfe4e84b73
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:127
is: P08319
initial amount: NaN
type: Species
name: ADH4
boundary condition: true

metaR RE1447N
reactant: MODEL1310110023#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110023#
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
name: RE1447

metaR r0634
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
fast: false
kinetic law: MODEL1310110023#
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.1.4.1
reversible: true
reactant: MODEL1310110023#
type: Reaction
modifier: MODEL1310110023#
is: SBO:0000176
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is described by: ECO:0000000

metaR INSTt2r
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
fast: false
type: Reaction
product: MODEL1310110023#
is: SBO:0000185
is described by: ECO:0000269
name: inositol transport in via proton symport
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110023#_61793fb2_1c36_4815_b113_8f62f19afd91
boundary condition: true
is: Q6GTM5
name: SC5DL
is encoded by: hsa:6309
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_3e36aa76_1840_4f8d_bfcb_51e612852716
is encoded by: hsa:1798
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
name: DPAGT1
initial amount: NaN
has only substance units: false
type: Species

metaR r0783
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
is described by: ECO:0000000
product: MODEL1310110023#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110023#
reactant: MODEL1310110023#
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
kinetic law: MODEL1310110023#
is: SBO:0000176
reversible: true
fast: false

metaR C226CRNt
reactant: MODEL1310110023#
name: C226 transport into the mitochondria
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
type: Reaction
product: MODEL1310110023#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110023#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110023#_a8ce011c_cbb9_4d5b_a0a2_3f603bcd7572
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
is: O14735
is encoded by: hsa:10423
has only substance units: false
constant: false
name: CDIPT
initial amount: NaN

metaR NDPK8
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110023#
fast: false
modifier: MODEL1310110023#
is described by: ECO:0000269
reversible: true
is: SBO:0000176
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110023#
name: Nucleoside-diphosphate kinase (ATP:dADP)

metaR RE1447M
product: MODEL1310110023#
fast: false
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
is: SBO:0000176
is described by: ECO:0000000
name: RE1447
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
reversible: true
type: Reaction
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.3.1.41

http://identifiers.org/biomodels.db/MODEL1310110023#_2af39979_a569_4fb8_ad7d_eed8239eaea3
is: SBO:0000252
is encoded by: hsa:10654
boundary condition: true
is: Q6FGV9
constant: false
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
name: PMVK

http://identifiers.org/biomodels.db/MODEL1310110023#_981531ec_2b00_4277_85fe_c5b62d2f383e
initial amount: NaN
is encoded by: hsa:5238
constant: false
has only substance units: false
boundary condition: true
name: PGM3
initial concentration: NaN
is: SBO:0000252
is: B4DX94
type: Species

metaM leuktrD4 e
is: SBO:0000247
is: HMDB03080
is: CHEBI:28666
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
name: Leukotriene D4
constant: false
boundary condition: false
has only substance units: false

metaM tdchola e
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
is: CHEBI:9407
initial amount: NaN
initial concentration: 1.0
is: HMDB00951
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
name: taurochenodeoxycholate
constant: false

metaM apoC Lys m
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:32551
notes: FORMULA: C6H13N2OX CHARGE: 0
boundary condition: false
initial amount: NaN
constant: false
is: HMDB00182
name: Apocarboxylase (Lys residue)

http://identifiers.org/biomodels.db/MODEL1310110023#_82cd6c0b_adba_4c39_a46c_9f60b4fdb269
is: Q548A7
has only substance units: false
is encoded by: hsa:65010
name: SLC26A6
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true

metaR r0633
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.7.3
reversible: true
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
type: Reaction
modifier: MODEL1310110023#
is: SBO:0000176
fast: false
product: MODEL1310110023#
kinetic law: MODEL1310110023#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:

metaM prostgh2 r
initial concentration: 1.0
name: prostaglandin H2(1-)
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
is: CHEBI:57405
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB01381
type: Species
initial amount: NaN

metaM HC00250 c
is: CHEBI:29919
initial concentration: 1.0
name: hydrosulfide
constant: false
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110023#_3d72a5a8_53a1_4d27_99a6_3739d6b652a0
is: SBO:0000252
is encoded by: hsa:206358
initial amount: NaN
name: SLC36A1
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is: Q1LZ56
constant: false

metaM 4hexdtricoa m
name: 4,7,10-hexadecatrienoylcoa
initial concentration: 1.0
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
is: HMDB02288

metaM dudp c
name: dUDP
has only substance units: false
initial amount: NaN
is: CHEBI:60471
is: HMDB01000
type: Species
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
initial concentration: 1.0
is: SBO:0000247
is: C01346
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110023#_71969439_9308_4de1_8344_be9d7ee8334f
boundary condition: true
name: GSTZ1
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:2954

metaR AICART
product: MODEL1310110023#
reactant: MODEL1310110023#
reversible: true
name: phosphoribosylaminoimidazolecarboxamide formyltransferase
is version of: http://identifiers.org/ec-code/2.1.2.3
type: Reaction
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
is: SBO:0000176
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#

metaM xol7ah c
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB06892
name: 7alpha-hydroxy-5beta-cholestan-3-one
boundary condition: false
is: CHEBI:2290
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-19,21-25,29H,6-16H2,1-5H3/t18-,19+,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01460 EHMN_ABBREVIATION: C05451
constant: false
type: Species

metaR MI1PS
name: myo-Inositol-1-phosphate synthase
fast: false
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/5.5.1.4
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (51477.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 5.5.1.4 Confidence Level: 4 AUTHORS: PMID:12941308 NOTES:NCD

metaR G3PD1
is: SBO:0000176
product: MODEL1310110023#
reactant: MODEL1310110023#
name: glycerol-3-phosphate dehydrogenase (NAD)
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
reversible: true
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.8

http://identifiers.org/biomodels.db/MODEL1310110023#_97cdc3e7_4fc0_4050_a789_72487f966033
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:4726
constant: false
name: NDUFS6
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: Q6IBC4

metaR 2OXOADOXm
product: MODEL1310110023#
fast: false
is version of: http://identifiers.org/ec-code/1.2.4.2
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.3.1.61
notes: GENE_ASSOCIATION: (4967.1) and (1738.1 and 8050.1) and (1743.1) or (4967.2) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Lysine metabolism EC Number: 2.3.1.61 Confidence Level: 2 AUTHORS: NOTES:SAB
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) (mitochondria)
type: Reaction
is: SBO:0000176
modifier: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000304
reversible: false
is version of: http://identifiers.org/ec-code/1.8.1.4

http://identifiers.org/biomodels.db/MODEL1310110023#_5783804b_c827_480c_8f05_e962e5dd5f72
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:137872
initial concentration: NaN
constant: false
is: Q8IWW8
name: ADHFE1
has only substance units: false
initial amount: NaN

metaR 3AIB Dtm
reactant: MODEL1310110023#
reversible: true
kinetic law: MODEL1310110023#
fast: false
is described by: ECO:0000134
is: SBO:0000185
name: transport of 3aib_D into mitochondria
type: Reaction
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: no transporter could be identified, so diffusion is assumed. NOTES:

metaR CHSTEROLt2
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110023#
name: cholesterol intracellular transport
type: Reaction
product: MODEL1310110023#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_6863c6a1_9980_40f5_b6a2_aec018c38ee3
name: ACOT6
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:641372
initial concentration: NaN
is: SBO:0000252
type: Species
is: Q3I5F7

metaM lys L e
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: HMDB00182
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
name: L-lysinium(1+)
boundary condition: false
has only substance units: false
is: CHEBI:32551
initial concentration: 1.0

metaM aacoa x
initial amount: NaN
is: CHEBI:57286
is: SBO:0000247
constant: false
boundary condition: false
name: acetoacetyl-CoA(4-)
has only substance units: false
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: HMDB01484
type: Species
initial concentration: 1.0

metaR r1301
kinetic law: MODEL1310110023#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
reactant: MODEL1310110023#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110023#
name: Vesicular transport

metaR EX lac D LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-lactate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_9e74373c_23c2_4b25_9149_cee49cede762
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:AI684467
type: Species
name: _AI684467_1_m
constant: false

metaR DTMPK
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.9
type: Reaction
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
reactant: MODEL1310110023#
product: MODEL1310110023#
fast: false
is: SBO:0000176
name: dTMP kinase
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#

metaR r1088
product: MODEL1310110023#
kinetic law: MODEL1310110023#
fast: false
reactant: MODEL1310110023#
is described by: ECO:0000000
type: Reaction
name: Active transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110023#_e548dfc2_7733_400e_8241_4f12d4d5dfda
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:LOC728997
name: _LOC728997_1_c
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110023#_c3d7c3df_f233_4c6d_8160_b756402cc549
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
name: FOLR1
is encoded by: hsa:2348
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_97b40d21_457b_4056_b56a_09b6ef88ecea
constant: false
type: Species
has only substance units: false
boundary condition: true
name: _NM_013421_1_e
is: SBO:0000252
is encoded by: hsa:NM 013421
initial concentration: NaN
initial amount: NaN

metaM tdchola c
constant: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
has only substance units: false
initial concentration: 1.0
is: CHEBI:9407
initial amount: NaN
is: HMDB00951
is: SBO:0000247
name: taurochenodeoxycholate
boundary condition: false
type: Species

metaR CHSTEROLt1
reactant: MODEL1310110023#
reversible: true
type: Reaction
kinetic law: MODEL1310110023#
is: SBO:0000185
name: cholesterol intracellular transport
fast: false
product: MODEL1310110023#
modifier: MODEL1310110023#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?

metaR r0784
is version of: http://identifiers.org/ec-code/1.3.1.38
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
modifier: MODEL1310110023#
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
fast: false
product: MODEL1310110023#
reactant: MODEL1310110023#
is: SBO:0000176
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110023#

metaM HC00250 e
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
name: hydrosulfide
is: CHEBI:29919

http://identifiers.org/biomodels.db/MODEL1310110023#_2d8e2b23_a7c1_44a8_852b_297562ce0abf
is: B4DYG5
boundary condition: true
has only substance units: false
initial concentration: NaN
name: PI4KA
type: Species
constant: false
is encoded by: hsa:5297
initial amount: NaN
is: SBO:0000252

metaR FAOXC122x
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_6a5a0a50_06c4_4d75_bfb3_eb639d39f695
is: SBO:0000252
name: SLC1A4
has only substance units: false
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6509
is: P43007

metaR H8TAer
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (10026.1) and (8733.1) and (128869.1) and (94005.1) and (51604.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10727241,PMID:11483512,PMID:12802054,PMID:15632136,PMID:9356492,PMID:9468317 NOTES:EC 2.6.-.- NCD
name: H8 transamidase, endoplasmic reticulum
is: SBO:0000176
kinetic law: MODEL1310110023#
product: MODEL1310110023#
is described by: ECO:0000000
reactant: MODEL1310110023#
modifier: MODEL1310110023#
fast: false

metaR NACHEXA9ly
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110023#
type: Reaction
is described by: ECO:0000000
reversible: false
name: beta-N-acetylhexosaminidase A, lysosomal
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
fast: false
is: SBO:0000176
reactant: MODEL1310110023#
modifier: MODEL1310110023#

metaR r0787
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.1
reactant: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
is: SBO:0000176
reversible: false
type: Reaction
product: MODEL1310110023#
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#

metaR DGK1
reactant: MODEL1310110023#
reversible: true
product: MODEL1310110023#
fast: false
is described by: ECO:0000269
name: deoxyguanylate kinase (dGMP:ATP)
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.8
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110023#
is: SBO:0000176
modifier: MODEL1310110023#

metaM ksi pre15 g
initial concentration: 1.0
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 15
notes: FORMULA: C149H240N10O119S4X CHARGE: -5
is: HMDB00175
is: CHEBI:58053
has only substance units: false
constant: false
is: SBO:0000247
is: C00130
type: Species
boundary condition: false

metaM lys L c
is: HMDB00182
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
name: L-lysinium(1+)
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: CHEBI:32551

metaM chsterol e
is: SBO:0000247
has only substance units: false
constant: false
name: cholesterol
initial concentration: 1.0
is: CHEBI:16113
boundary condition: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
is: HMDB00067
initial amount: NaN
type: Species

metaR H2Otly
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110023#
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110023#
name: H2O transport, lysosomal
product: MODEL1310110023#

metaR r0638
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
modifier: MODEL1310110023#
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is version of: http://identifiers.org/ec-code/2.8.1.2
reversible: true
product: MODEL1310110023#

metaM dolp U r
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:57683
type: Species
is: SBO:0000247
name: dolichyl phosphate(2-)
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110

metaR NDP7er
product: MODEL1310110023#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum
is described by: ECO:0000000
is: SBO:0000176
fast: false

metaR r0926
is described by: ECO:0000000
fast: false
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:
kinetic law: MODEL1310110023#
reversible: false
is: SBO:0000185
type: Reaction
name: Postulated transport reaction
product: MODEL1310110023#

metaR 4HBZCOAFm
type: Reaction
fast: false
is described by: ECO:0000000
name: 4-hydroxybenzoyl-CoA formation
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
reversible: false
is: SBO:0000176
product: MODEL1310110023#
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_707dc395_5647_4706_ac80_2de27c9a02de
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
name: ACOT2
is encoded by: hsa:10965
type: Species
is: P49753
is: SBO:0000252
initial concentration: NaN

metaR RE3001M
name: RE3001
product: MODEL1310110023#
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
modifier: MODEL1310110023#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.34
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#

metaR S6T13g
is described by: ECO:0000000
reactant: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: (4166.1) or (10164.1) or (23563.2) or (23563.1) or (9435.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
product: MODEL1310110023#
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110023#_6f666a4f_59ac_4112_827f_0f4faaff95e9
constant: false
is encoded by: hsa:85365
has only substance units: false
is: SBO:0000252
boundary condition: true
is: Q9H553
initial concentration: NaN
type: Species
name: ALG2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_80a58593_3917_458d_88c7_d7c6fbbc2ef7
is encoded by: hsa:3158
type: Species
initial amount: NaN
is: P54868
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
name: HMGCS2
has only substance units: false

metaR GALASE16ly
reactant: MODEL1310110023#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
fast: false
modifier: MODEL1310110023#

metaR SIAASE3ly
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.2.1.18
name: sialidase, lysosomal
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
product: MODEL1310110023#
modifier: MODEL1310110023#
reversible: false
type: Reaction
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false

metaR CHSTEROLt3
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110023#
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110023#
fast: false
name: cholesterol intracellular transport
product: MODEL1310110023#

metaR NACHEXA15ly
reversible: false
reactant: MODEL1310110023#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110023#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase A, lysosomal
modifier: MODEL1310110023#
product: MODEL1310110023#

metaR CYTK8n
product: MODEL1310110023#
is described by: ECO:0000269
fast: false
type: Reaction
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP,dATP),nuclear
modifier: MODEL1310110023#
is: SBO:0000176
reactant: MODEL1310110023#

metaR r1881
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110023#
is: SBO:0000185
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110023#
name: Y+LAT2 Utilized transport

metaM decdp m
initial concentration: 1.0
name: all trans Decaprenyl diphosphate
has only substance units: false
type: Species
notes: FORMULA: C50H81O7P2 CHARGE: -3 INCHI: InChI=1/C50H90O7P2/c1-41(2)21-31-53-58(51,54-32-22-42(3)4)57-59(52,35-25-45(9)10,36-26-46(11)12,37-27-47(13)14,38-28-48(15)16,39-29-49(17)18,40-30-50(19)20,55-33-23-43(5)6)56-34-24-44(7)8/h21-30H,31-40H2,1-20H3
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB06288

metaR r0789
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
product: MODEL1310110023#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.13.15
modifier: MODEL1310110023#
fast: false
reversible: true
is described by: ECO:0000000
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
kinetic law: MODEL1310110023#

metaM pail5p hs n
is: CHEBI:57795
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
boundary condition: false
type: Species
has only substance units: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110023#_9a51012e_8506_43bb_8025_0071c60d7885
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:51292
name: GMPR2
constant: false
is: Q86T14

metaR AG13T10g
is: SBO:0000176
kinetic law: MODEL1310110023#
is described by: ECO:0000000
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10331.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
reversible: false
product: MODEL1310110023#
reactant: MODEL1310110023#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_e7a1e10f_5f44_458f_b6e9_2d8be44b27e7
constant: false
initial amount: NaN
name: ENPP1
is encoded by: hsa:5167
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
is: P22413
has only substance units: false

metaR ARACHDt2
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
is: SBO:0000185
name: fatty acid transport via diffusion
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
reversible: true
product: MODEL1310110023#

metaM HC01522 c
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: Gentisate aldehyde
type: Species
is: CHEBI:28508
constant: false

metaM chsterol c
name: cholesterol
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
boundary condition: false
is: CHEBI:16113
type: Species
is: HMDB00067
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_b27397f4_64be_47de_aab4_7ca267edef79
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:H17063
constant: false
boundary condition: true
name: _H17063_1_m

http://identifiers.org/biomodels.db/MODEL1310110023#_4325d5ec_b9a4_410b_b64c_d69c98cf7677
constant: false
is: SBO:0000252
is encoded by: hsa:483
type: Species
initial concentration: NaN
name: ATP1B3
initial amount: NaN
has only substance units: false
boundary condition: true
is: P54709

metaM L2aadp c
is: HMDB00510
constant: false
initial amount: NaN
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
name: L-2-aminoadipate(1-)
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:58672
boundary condition: false
initial concentration: 1.0

metaM tcynt m
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:18022
has only substance units: false
name: thiocyanate
type: Species
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
is: HMDB01453

metaM ksi deg9 l
initial amount: NaN
is: CHEBI:12936
type: Species
boundary condition: false
is: HMDB00143
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C188H301N13O166S10 CHARGE: -10
constant: false
name: keratan sulfate I, degradation product 9

metaM pyam5p c
is: C00647
is: HMDB01555
name: Pyridoxamine 5'-phosphate
is: CHEBI:58451
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
notes: FORMULA: C8H12N2O5P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00475 EHMN_ABBREVIATION: C00647
boundary condition: false

metaM gln L m
constant: false
name: L-glutamine
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:18050
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
boundary condition: false
has only substance units: false
is: HMDB00641
is: SBO:0000247

metaR r0788
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.14.13.15
reactant: MODEL1310110023#
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000000
modifier: MODEL1310110023#
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
reversible: true

metaR MI1PP
name: myo-inositol 1-phosphatase
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.25
reversible: false
type: Reaction
reactant: MODEL1310110023#
product: MODEL1310110023#
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
fast: false
kinetic law: MODEL1310110023#

metaM fprica c
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:58467
notes: FORMULA: C10H13N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01344 EHMN_ABBREVIATION: C04734
is: C04734
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
type: Species
boundary condition: false
is: HMDB01439
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110023#_07f99a3d_6aed_4176_8d90_660afcfc1044
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:23396
name: PIP5K1C
boundary condition: true
is: O60331
initial concentration: NaN

metaR GRTT
reversible: false
fast: false
product: MODEL1310110023#
type: Reaction
name: geranyltranstransferase
notes: GENE_ASSOCIATION: (9453.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 2 AUTHORS: PMID:17477828,PMID:17477829 NOTES:Human Y/N: Y
is described by: ECO:0000134
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.5.1.1
modifier: MODEL1310110023#
is: SBO:0000176

metaM h2o x
type: Species
is: HMDB02111
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
is: C00001
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: SBO:0000247
is: CHEBI:15377
name: H2O

http://identifiers.org/biomodels.db/MODEL1310110023#_0f4c7297_af14_4adc_ad38_42310e5d8498
constant: false
initial concentration: NaN
is: SBO:0000252
name: ADSSL1
initial amount: NaN
has only substance units: false
is encoded by: hsa:122622
boundary condition: true
type: Species
is: Q8N142

http://identifiers.org/biomodels.db/MODEL1310110023#_e2ab1151_01fd_49ec_9638_d99453d66050
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
name: NDUFAB1
type: Species
is encoded by: hsa:4706
is: O14561
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110023#_1584b97e_49ca_4d6f_8248_1a45bcbe4733
is encoded by: hsa:3939
is: SBO:0000252
name: LDHA
initial concentration: NaN
has only substance units: false
is: P00338
initial amount: NaN
type: Species
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110023#_0342bfaa_77e8_4a15_8101_fee659b5ab40
type: Species
has only substance units: false
is encoded by: hsa:79071
boundary condition: true
is: Q9H5J4
initial amount: NaN
is: SBO:0000252
name: ELOVL6
initial concentration: NaN
constant: false

metaR RE1530C
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
name: RE1530
is described by: ECO:0000000
type: Reaction
product: MODEL1310110023#
is: SBO:0000176
reversible: true
fast: false
reactant: MODEL1310110023#

metaR AG13T12g
type: Reaction
reversible: false
is: SBO:0000176
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
product: MODEL1310110023#
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110023#_85f19539_7910_4884_897c_eb70149af9af
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:728226
name: _728226_1_m

http://identifiers.org/biomodels.db/MODEL1310110023#_a64b44a3_0839_4eaa_8d4d_bd1f2132d979
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
type: Species
has only substance units: false
is: Q8NFL0
name: B3GNT7
is encoded by: hsa:93010
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_852500f1_cbfb_4c6e_8962_04d6f619f6ef
boundary condition: true
has only substance units: false
is: P15291
is encoded by: hsa:2683
initial concentration: NaN
constant: false
type: Species
name: B4GALT1
is: SBO:0000252
initial amount: NaN

metaM 42A3HP24DB c
type: Species
initial amount: NaN
is: HMDB04083
has only substance units: false
is: http://identifiers.org/pubchem.compound/7956
is: C05645
notes: FORMULA: C10H8NO5 CHARGE: -1 INCHI: InChI=1/C10H9NO5/c11-9-5(2-1-3-6(9)12)7(13)4-8(14)10(15)16/h1-3,12H,4,11H2,(H,15,16) HEPATONET_1.0_ABBREVIATION: HC01547 EHMN_ABBREVIATION: C05645
boundary condition: false
initial concentration: 1.0
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
is: SBO:0000247
constant: false

metaM ha deg1 l
has only substance units: false
name: hyaluronan degradation product 1
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:16336
notes: FORMULA: C22H33N2O16 CHARGE: -1
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_f43b447c_38cf_4591_bb87_15b5d4b6ccec
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1329
constant: false
boundary condition: true
is: Q53YB7
is: SBO:0000252
name: COX5B

http://identifiers.org/biomodels.db/MODEL1310110023#_2db5c0da_87f8_4fbd_b917_71bf1db530f4
has only substance units: false
is encoded by: hsa:3948
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
name: LDHC
initial amount: NaN

metaM uri e
is: HMDB00296
is: C00299
type: Species
is: CHEBI:16704
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
has only substance units: false
name: Uridine

metaR r0527
reversible: true
is described by: ECO:0000000
name: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:
is: SBO:0000176
reactant: MODEL1310110023#
product: MODEL1310110023#
type: Reaction
kinetic law: MODEL1310110023#

metaM q10 m
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: ubiquinone-10
is: HMDB01072
constant: false
has only substance units: false
is: CHEBI:46245
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378

http://identifiers.org/biomodels.db/MODEL1310110023#_fc238b5a_bc1f_4351_932d_245dd51e3b38
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:2678
name: GGT1

metaR DESAT18 6
kinetic law: MODEL1310110023#
product: MODEL1310110023#
type: Reaction
name: fatty acyl-CoA desaturase (n-C18:1CoA -> n-C18:2CoA)
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110023#
fast: false
reversible: false
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.99.25 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ

metaM hista c
constant: false
has only substance units: false
is: CHEBI:58432
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
is: HMDB00870
initial amount: NaN
name: histamium
type: Species
boundary condition: false

metaR FACOAL170
product: MODEL1310110023#
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR
fast: false
reactant: MODEL1310110023#
reversible: true
modifier: MODEL1310110023#
is described by: ECO:0000000
kinetic law: MODEL1310110023#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction

metaM malt c
is: CHEBI:17306
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00194 EHMN_ABBREVIATION: C00208
is: HMDB00163
is: SBO:0000247
name: Maltose
is: C00208
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_153a580c_2bbb_44cd_bc14_9d84c7f5de08
initial amount: NaN
is: O75356
boundary condition: true
is encoded by: hsa:957
is: SBO:0000252
name: ENTPD5
type: Species
has only substance units: false
constant: false
initial concentration: NaN

metaR r1299
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110023#
product: MODEL1310110023#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110023#
fast: false
reversible: false
name: Vesicular transport
type: Reaction

metaR DCYTt
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110023#
name: deoxycytidine transport via diffusion
reactant: MODEL1310110023#
reversible: true

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaR XYLTt
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110023#
reversible: true
fast: false
name: Xylitol transport via passive diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES:NCD
kinetic law: MODEL1310110023#
product: MODEL1310110023#

metaR PROD2m
fast: false
product: MODEL1310110023#
type: Reaction
reactant: MODEL1310110023#
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.5.99.8
name: Proline dehydrogenase (m)
kinetic law: MODEL1310110023#
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR SAB m
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110023#_d8fa3648_3931_49e7_9dab_86027c0fc69a
name: NDUFS6
initial amount: NaN
is encoded by: hsa:4726
boundary condition: true
is: Q6IBC4
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR CYOOm3
is: SBO:0000185
name: cytochrome c oxidase, mitochondrial Complex IV
reversible: false
product: MODEL1310110023#
kinetic law: MODEL1310110023#
is described by: ECO:0000134
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.9.3.1
type: Reaction
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
fast: false
modifier: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_abd42cd5_2ab6_42a1_8e8e_ae3d89ceaf16
is: SBO:0000252
is encoded by: hsa:4537
type: Species
is: P03897
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
name: ND3

metaM gluside hs g
is: SBO:0000247
is: CHEBI:18368
name: D-glucosyl-N-acylsphingosine
initial amount: NaN
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190

metaR PIt8
type: Reaction
modifier: MODEL1310110023#
reversible: true
fast: false
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000006
name: phosphate transport in/out via Na+ symporter
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
is: SBO:0000185

metaM h2o2 n
has only substance units: false
boundary condition: false
name: hydrogen peroxide
initial amount: NaN
constant: false
is: CHEBI:16240
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: HMDB03125
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR r1298
type: Reaction
reactant: MODEL1310110023#
product: MODEL1310110023#
is: SBO:0000185
kinetic law: MODEL1310110023#
fast: false
reversible: false
name: Vesicular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110023#_7cb58387_acd6_4ae5_b659_ae570491150d
constant: false
name: GLUD2
boundary condition: true
is: P49448
initial concentration: NaN
is encoded by: hsa:2747
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110023#_22131ee3_6307_460f_91d4_dc0815b374c9
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
name: GOT2
is: SBO:0000252
type: Species
is encoded by: hsa:2806
is: P00505
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_fa855153_38f5_4f7a_9188_44dc5068ba05
initial concentration: NaN
is encoded by: hsa:1644
constant: false
boundary condition: true
name: DDC
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q53Y41

metaR XYLUR
product: MODEL1310110023#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110023#
name: xylulose reductase
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.1.1.10
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (51181.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.10 Confidence Level: 4 AUTHORS: PMID:11882650,PMID:6821187 NOTES:
type: Reaction
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110023#_97b44eb9_2b30_4957_8f4a_7c1a2cea6bed
is encoded by: hsa:6647
type: Species
is: P00441
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
name: SOD1

metaM no c
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
initial amount: NaN
is: CHEBI:16480
has only substance units: false
type: Species
is: C00533
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
name: Nitric oxide
is: HMDB03378

metaM uri c
is: HMDB00296
is: C00299
type: Species
is: CHEBI:16704
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
name: Uridine
constant: false
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
initial amount: NaN

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

metaR G14T2g
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
type: Reaction
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110023#
fast: false
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110023#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

http://identifiers.org/biomodels.db/MODEL1310110023#_cd8a5a10_e54e_4a3c_aeb6_406e847e5ca0
has only substance units: false
is: Q9NRX3
name: NDUFA4L2
constant: false
boundary condition: true
type: Species
is encoded by: hsa:56901
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR ACGALtly
reversible: false
kinetic law: MODEL1310110023#
is described by: ECO:0000000
name: N-acetyl-galactosamine lysosomal efflux
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
type: Reaction
reactant: MODEL1310110023#
is: SBO:0000185
product: MODEL1310110023#

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_fa624243_93f3_4263_b574_acd69db2f507
type: Species
is encoded by: hsa:4831
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
has part: P22392
has part: P15531
is encoded by: hsa:4830
name: NME1:NME2
initial amount: NaN
is: SBO:0000297

metaM malt e
is: HMDB00163
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00194 EHMN_ABBREVIATION: C00208
is: C00208
constant: false
name: Maltose
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:17306

metaR r0892
kinetic law: MODEL1310110023#
fast: false
product: MODEL1310110023#
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/3.1.2.27
type: Reaction
name: Facilitated diffusion
is: SBO:0000185
modifier: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110023#_2c4e32af_e267_4186_a01f_5738fcaebf92
initial concentration: NaN
has only substance units: false
name: ALDH1A1
is: SBO:0000252
is encoded by: hsa:216
type: Species
constant: false
initial amount: NaN
is: P00352
boundary condition: true

metaM nadp m
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: CHEBI:58349
is: HMDB00217
type: Species
name: Nicotinamide adenine dinucleotide phosphate
constant: false
has only substance units: false
initial concentration: 1.0
is: C00006
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaR r0747
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1554355,PMID:1591235,PMID:3459552 NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
is: SBO:0000176
name: 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
fast: false
modifier: MODEL1310110023#
product: MODEL1310110023#

metaR LYStip
fast: false
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
reversible: false
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:6811962 NOTES:MM
is: SBO:0000185
is described by: ECO:0000000
name: L-lysine transport, peroxisomal (irreversible)
type: Reaction

metaR FAOXC225C226m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_b76144e8_fe80_4501_a1cf_cd8af718d2ac
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
name: _AA526438_1_c
constant: false
initial amount: NaN
is encoded by: hsa:AA526438

http://identifiers.org/biomodels.db/MODEL1310110023#_d45c12e6_69a9_427b_93e1_266d6ec71fe7
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:6817
initial concentration: NaN
type: Species
is: P50225
name: SULT1A1

metaR HPDCACRNt
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ
kinetic law: MODEL1310110023#
is: SBO:0000185
reversible: false
name: heptadecanoate transport into the mitochondria
is described by: ECO:0000269
modifier: MODEL1310110023#
reactant: MODEL1310110023#
product: MODEL1310110023#
type: Reaction

metaR OCT11EFATP
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of vaccenic acid by cells
type: Reaction

metaM xol7ah2al m
initial amount: NaN
is: HMDB06894
initial concentration: 1.0
type: Species
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
constant: false
boundary condition: false
is: SBO:0000247
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
is: CHEBI:27428
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_c3e58afe_91f2_4fe5_b1c8_aa612affaa2a
is encoded by: hsa:686
initial amount: NaN
is: P43251
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
type: Species
boundary condition: true
name: BTD

metaR H2O2t
reactant: MODEL1310110023#
is described by: ECO:0000000
kinetic law: MODEL1310110023#
name: hydrogen peroxide transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF
fast: false
reversible: true
product: MODEL1310110023#
type: Reaction
is: SBO:0000185

metaM thmmp m
name: thiamine(1+) monophosphate(2-)
notes: FORMULA: C12H16N4O4PS CHARGE: -1 INCHI: InChI=1S/C12H17N4O4PS/c1-8-11(3-4-20-21(17,18)19)22-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H3-,13,14,15,17,18,19)/p-1 EHMN_ABBREVIATION: C01081
initial concentration: 1.0
initial amount: NaN
is: CHEBI:37575
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB02666
constant: false
type: Species

metaM pheacgln c
initial amount: NaN
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
has only substance units: false
is: HMDB06344
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
is: CHEBI:58310
type: Species
is: SBO:0000247
constant: false

metaM nadp r
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: Nicotinamide adenine dinucleotide phosphate
type: Species
is: CHEBI:58349
constant: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: HMDB00217
is: C00006
is: SBO:0000247

metaR r0744
type: Reaction
is: SBO:0000176
product: MODEL1310110023#
fast: false
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
reversible: false
name: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl- CoA hydro-lyase Bile acid biosynthesis EC:4.2.1.107
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 4.2.1.107 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110023#_dcdc0cf0_a3de_4588_8129_776ff6e47ad6
type: Species
constant: false
name: GART
is: P22102
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:2618
has only substance units: false
is: SBO:0000252

metaR RE3244R
reactant: MODEL1310110023#
modifier: MODEL1310110023#
is: SBO:0000176
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
product: MODEL1310110023#
type: Reaction
kinetic law: MODEL1310110023#
fast: false
reversible: true
name: RE3244
is described by: ECO:0000000

metaR RE3520E
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.11.1.9
fast: false
product: MODEL1310110023#
is: SBO:0000176
kinetic law: MODEL1310110023#
name: RE3520
modifier: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_04baddee_d19d_4c7b_b494_7e39949ba734
is: SBO:0000252
type: Species
name: ATP2B2
boundary condition: true
is encoded by: hsa:491
initial amount: NaN
is: Q4J699
constant: false
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_739c5692_e51d_45fb_8df4_eb1b450086be
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
name: SLC25A26
is encoded by: hsa:115286
constant: false
initial amount: NaN
boundary condition: true

metaR PIt7
name: phosphate transport in/out via three Na+ symporter
fast: false
reactant: MODEL1310110023#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
modifier: MODEL1310110023#
is: SBO:0000185
kinetic law: MODEL1310110023#
is described by: ECO:0000269
product: MODEL1310110023#

metaR PRISTANALtx
fast: false
name: pristanal peroxisomal transport
reversible: true
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110023#
type: Reaction
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ
kinetic law: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_cbebb5d6_1218_4475_a21c_3f58062cd96a
constant: false
name: GALNT1
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: Q10472
has only substance units: false
boundary condition: true
is encoded by: hsa:2589
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_8846aa06_8991_4d18_bf39_389ee7436296
initial concentration: NaN
has only substance units: false
name: SLCO1A2
type: Species
is: SBO:0000252
is encoded by: hsa:6579
constant: false
initial amount: NaN
boundary condition: true
is: P46721

http://identifiers.org/biomodels.db/MODEL1310110023#_4052c52c_df48_4b94_8182_401dd9aaa0e2
is encoded by: hsa:9453
name: GGPS1
boundary condition: true
has only substance units: false
type: Species
is: O95749
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN

metaR EX for LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Formate exchange
type: Reaction

metaR r0410
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reactant: MODEL1310110023#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110023#
reversible: true
fast: false
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
product: MODEL1310110023#

metaM prist x
initial amount: NaN
name: pristanic acid
has only substance units: false
constant: false
is: CHEBI:51340
is: HMDB00795
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_1e22560c_1723_4996_8da7_64b0b2ed935c
name: ALDH3B2
initial amount: NaN
is: P48448
constant: false
is encoded by: hsa:222
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252

metaM prostge1 c
is: CHEBI:57397
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB01442
constant: false
name: prostaglandin E1(1-)

metaR ALDD2x
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
modifier: MODEL1310110023#
is: SBO:0000176
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.2.1.36
type: Reaction
reversible: false
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (218.1) or (501.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (223.1) or (220.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:Only acetaldehyde considered for now. See also 1.2.1.4. Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. Formerly EC 1.1.1.70; r0176
is version of: http://identifiers.org/ec-code/1.2.1.3
name: aldehyde dehydrogenase (acetaldehyde, NAD)
kinetic law: MODEL1310110023#
is described by: ECO:0000000

metaR HCO3 CLt
modifier: MODEL1310110023#
name: bicarbonate transport (Cl-/HCO3- exchange)
reactant: MODEL1310110023#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6522.1) or (83697.1) or (6521.1) or (6508.2) or (6508.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11302728,PMID:12027221,PMID:14722772 NOTES:MM
product: MODEL1310110023#
kinetic law: MODEL1310110023#
fast: false
is: SBO:0000185
type: Reaction

metaM pheacgln e
is: CHEBI:58310
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
constant: false
initial concentration: 1.0
is: HMDB06344
initial amount: NaN
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_eff62751_09cc_43f8_817b_f4c8363d48ef
is encoded by: hsa:6713
is: Q5HYI4
constant: false
type: Species
initial amount: NaN
name: SQLE
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110023#_011bc39e_e13e_45d1_9a11_d3ee2aac5039
is encoded by: hsa:130
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
name: ADH6
type: Species
is: P28332
boundary condition: true
has only substance units: false

metaM ksi l
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
name: keratan sulfate I
boundary condition: false
is: CHEBI:57455
has only substance units: false
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
is: HMDB01354
initial concentration: 1.0
is: C00445

http://identifiers.org/biomodels.db/MODEL1310110023#_fadda21a_4f5d_4fe1_89e2_15fb53c5947e
initial concentration: NaN
is: Q96CA6
is: SBO:0000252
constant: false
boundary condition: true
name: ACAA1
type: Species
is encoded by: hsa:30
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_86511b1a_acdd_4fd7_92dd_96d2f3b69a84
constant: false
type: Species
initial amount: NaN
name: GSR
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2936
is: P00390
is: SBO:0000252
has only substance units: false

metaM HC01405 m
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:28632
has only substance units: false
constant: false
is: SBO:0000247
name: (S)-Hydroxyoctanoyl-CoA
type: Species
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

metaR ALDD2y
reactant: MODEL1310110023#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.3
name: aldehyde dehydrogenase (acetaldehyde, NADP)
product: MODEL1310110023#
reversible: false
notes: GENE_ASSOCIATION: (223.1) or (221.1) or (218.1) or (8854.1) or (8854.3) or (222.1) or (8854.2) or (224.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.4 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:See also ALDH1 (1.2.1.3); r0177
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.36

metaR UMPK5n
is: SBO:0000176
name: UMP kinase (dATP),nuclear
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110023#
modifier: MODEL1310110023#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110023#

metaR IPDDI
is described by: ECO:0000134
kinetic law: MODEL1310110023#
fast: false
product: MODEL1310110023#
name: isopentenyl-diphosphate D-isomerase
notes: GENE_ASSOCIATION: SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 3 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book.
reversible: true
is: SBO:0000176
reactant: MODEL1310110023#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_c46fe974_f9f9_4769_a458_b6339e973cf2
name: ECH1
has only substance units: false
constant: false
is: SBO:0000252
is: Q13011
is encoded by: hsa:1891
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_879fbdd5_afd3_4e3a_a7da_18aead69944d
name: PIK3C2G
is: O75747
is encoded by: hsa:5288
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false

metaR TAGt
name: triacylglycerol transport
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
fast: false

metaR PI345P3P
type: Reaction
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
is: SBO:0000176
is described by: ECO:0000000
name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
reactant: MODEL1310110023#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (5728.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 4 AUTHORS: PMID:11463863 NOTES:NCD
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.1.3.67

metaM hista e
is: CHEBI:58432
boundary condition: false
has only substance units: false
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
initial amount: NaN
is: SBO:0000247
is: HMDB00870
initial concentration: 1.0
type: Species
constant: false
name: histamium

metaR FAOXC101m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)m
type: Reaction

metaM cspg a e
has only substance units: false
is: C00106
is: CHEBI:17568
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB00300
initial concentration: 1.0
constant: false
type: Species

metaM 10fthf6glu e
boundary condition: false
initial amount: NaN
is: CHEBI:57454
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB00972
name: 10-formyltetrahydrofolate-[Glu](6)
is: SBO:0000247
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110023#_e0571bf3_3485_4d5e_a92b_fdec5015a7e2
initial concentration: NaN
is: O43252
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: PAPSS1
type: Species
constant: false
has only substance units: false
is encoded by: hsa:9061

metaR S6T2g
kinetic law: MODEL1310110023#
product: MODEL1310110023#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110023#
modifier: MODEL1310110023#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

metaM 10fthf7glu e
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C50H57N13O25 CHARGE: -8
is: SBO:0000247
type: Species
is: HMDB00972
initial concentration: 1.0
name: 10-formyltetrahydrofolate-[Glu](7)
constant: false
is: CHEBI:57454

http://identifiers.org/biomodels.db/MODEL1310110023#_0065ff11_2f4f_41c4_b3cf_48b3ce736430
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:195814
is: B3KT84
name: SDR16C5
initial amount: NaN
is: SBO:0000252
constant: false

metaR FK
is described by: ECO:0000000
modifier: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: (197258.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.52 Confidence Level: 0 AUTHORS: NOTES:kh 1/6/03 NCD
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.52
name: Fucokinase
is: SBO:0000176
product: MODEL1310110023#
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#

metaM andrstandn r
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
initial concentration: 1.0
is: HMDB00899
name: 5alpha-androstane-3,17-dione
is: SBO:0000247
type: Species
is: CHEBI:15994

http://identifiers.org/biomodels.db/MODEL1310110023#_e56f4228_64d9_40ee_a3c0_44408a4d0e3b
type: Species
name: PIGP
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:51227
is: SBO:0000252
boundary condition: true

metaR 13DAMPPOX
reactant: MODEL1310110023#
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
kinetic law: MODEL1310110023#
fast: false
product: MODEL1310110023#
type: Reaction
modifier: MODEL1310110023#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.21
is version of: http://identifiers.org/ec-code/1.4.3.22
reversible: false
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)

http://identifiers.org/biomodels.db/MODEL1310110023#_939036c9_3e8b_40ec_b2bd_588f148c61ae
has only substance units: false
is: Q9NPB1
name: NT5M
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:56953
constant: false
boundary condition: true
initial amount: NaN
type: Species

metaR r0743
fast: false
kinetic law: MODEL1310110023#
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110023#
type: Reaction
reversible: false
is: SBO:0000176
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.3.1.85
name: hydroxysteroid (17-beta) dehydrogenase 4 Bile acid biosynthesis EC:1.1.1.35

metaM prostge1 e
boundary condition: false
is: CHEBI:57397
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB01442
has only substance units: false
initial amount: NaN
constant: false
name: prostaglandin E1(1-)

metaM HC01231 m
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
is: CHEBI:58480
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
constant: false
name: N-[(R)-pantothenoyl]-L-cysteinate

metaR GLCNACT U
type: Reaction
kinetic law: MODEL1310110023#
name: UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase (uterus)
fast: false
product: MODEL1310110023#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.141 Confidence Level: 0 AUTHORS: NOTES:

metaM pro D e
boundary condition: false
is: SBO:0000247
name: D-proline
has only substance units: false
type: Species
is: CHEBI:16313
constant: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
initial concentration: 1.0
is: HMDB03411
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_9670ff26_51e1_43d1_b33b_425095ba951c
is: SBO:0000252
is: Q9H3H5
is encoded by: hsa:1798
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
type: Species
name: DPAGT1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_49e3a076_385a_4ff2_9d67_3ce002861e05
is encoded by: hsa:441024
has only substance units: false
type: Species
is: SBO:0000252
name: MTHFD2L
is: Q9H903
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false

metaR DTTPtn
is described by: ECO:0000000
reactant: MODEL1310110023#
product: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: dTTP diffusion in nucleus
kinetic law: MODEL1310110023#
reversible: true
type: Reaction
is: SBO:0000185

metaM undcoa m
name: undecanoylcoa
initial concentration: 1.0
notes: FORMULA: C32H52N7O17P3S CHARGE: -4
is: HMDB13114
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_9284c976_bcb1_4187_af33_c1827f7ee8c3
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
is: B4DZR2
is encoded by: hsa:8854
initial amount: NaN
name: ALDH1A2
type: Species

metaM h2o2 x
is: C00027
is: SBO:0000247
constant: false
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
name: Hydrogen peroxide
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:16240
is: HMDB03125
has only substance units: false
initial amount: NaN

metaR EX pydxn LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Pyridoxine
type: Reaction

metaM akg x
is: CHEBI:16810
initial amount: NaN
is: HMDB00208
is: SBO:0000247
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
name: 2-oxoglutarate(2-)

http://identifiers.org/biomodels.db/MODEL1310110023#_9239330f_018d_48a4_b2b5_ccd7103d012f
is: SBO:0000252
name: DGKG
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1608
constant: false
is: P49619
initial amount: NaN

metaR r0741
fast: false
is described by: ECO:0000000
reactant: MODEL1310110023#
product: MODEL1310110023#
type: Reaction
reversible: true
is: SBO:0000176
modifier: MODEL1310110023#
name: 5beta-Cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating) Bile acid biosynthesis EC:1.14.13.15
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:271969,PMID:4026854,PMID:7077149 NOTES:IT - HepatoNet mapping of HC01455 to dhochoylcoa was wrong, xoltetrol is correct mapping. Therefore, r0742 is identical to P45027A11m and r0741 is cytosol version of P45027A11m

metaR NACHEX21ly
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110023#
is: SBO:0000176
kinetic law: MODEL1310110023#
fast: false
reactant: MODEL1310110023#
reversible: false

metaR ORPT
reversible: true
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.4.2.10
type: Reaction
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.4.2.10 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
fast: false
modifier: MODEL1310110023#
reactant: MODEL1310110023#
is: SBO:0000176
name: orotate phosphoribosyltransferase
is described by: ECO:0000269

metaM 1pipdn2c x
type: Species
initial amount: NaN
initial concentration: 1.0
name: 1-piperideine-2-carboxylate
has only substance units: false
boundary condition: false
is: HMDB01084
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092
constant: false
is: SBO:0000247
is: CHEBI:16187

metaM q10 e
is: HMDB01072
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
type: Species
is: CHEBI:46245
name: ubiquinone-10

http://identifiers.org/biomodels.db/MODEL1310110023#_0743d3aa_205e_4c32_881f_5ac2f3514b25
name: SDHA
has only substance units: false
initial concentration: NaN
is: P31040
boundary condition: true
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:6389
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_e69498c1_1347_4970_8386_5b9826ac7a59
is encoded by: hsa:65010
is: SBO:0000252
constant: false
is: Q9NQU1
has only substance units: false
initial amount: NaN
type: Species
name: SLC26A6
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110023#_50bedbc4_adec_4e2a_96fd_951a8cc321bd
has part: Q07326
constant: false
is encoded by: hsa:84720
is: SBO:0000297
name: PIGF:PIGO
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
has part: Q8TEQ8
has only substance units: false
is encoded by: hsa:5281

metaM cala c
boundary condition: false
constant: false
is: HMDB00026
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642
has only substance units: false
type: Species
is: CHEBI:11892
name: N-carbamoyl-beta-alaninate
initial amount: NaN

metaM mlthf c
initial amount: NaN
is: HMDB01533
is: CHEBI:15636
type: Species
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
is: C00143
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: 5,10-Methylenetetrahydrofolate

http://identifiers.org/biomodels.db/MODEL1310110023#_9b5fec10_623a_4a62_b1e7_ee4f7780e1a4
name: COASY
is encoded by: hsa:80347
constant: false
is: Q13057
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN

metaR r0899
product: MODEL1310110023#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
is described by: ECO:0000000
fast: false
name: Amino acid transporter ATB0+ Facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
reversible: true

metaR HISCAT1
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

metaM ahcys c
name: S-Adenosyl-L-homocysteine
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB00939
boundary condition: false
constant: false
is: CHEBI:16680
is: C00021
initial amount: NaN
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021

metaM pro D c
type: Species
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:16313
has only substance units: false
name: D-proline
is: HMDB03411
initial concentration: 1.0
is: SBO:0000247

metaR PIACGT
product: MODEL1310110023#
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.83
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.4.1.198
modifier: MODEL1310110023#
reversible: false
name: phosphatidylinositol N-acetylglucosaminyltransferase
notes: GENE_ASSOCIATION: (5279.1) and (51227.2) and (5283.1) and (5277.2) and (9091.1) and (8818.1) or (5279.1) and (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) or (51227.1) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.2) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (5279.2) and (8818.1) or (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.1) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.2) or (51227.1) and (5277.1) and (5283.1) and (9091.1) and (5279.2) and (8818.1) or (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (9091.2) and (5277.3) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (8818.2) and (5279.2) or (5279.1) and (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.2) or (51227.1) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.2) and (9091.2) and (5277.1) and (5283.1) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.2) and (5283.1) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (5283.1) and (5277.2) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (5283.1) and (5277.2) and (9091.1) and (8818.2) or (51227.3) and (9091.2) and (5283.1) and (5277.2) and (5279.2) and (8818.1) or (5279.1) and (51227.3) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (51227.1) and (9091.2) and (5277…
kinetic law: MODEL1310110023#

metaM fald c
boundary condition: false
type: Species
name: formaldehyde
initial concentration: 1.0
is: CHEBI:16842
has only substance units: false
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB01426

metaR GALASE3ly
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
fast: false
name: beta-galactosidase, lysosomal

metaM HC00460 c
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
name: 2,5-dihydroxybenzoate
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
boundary condition: false
is: CHEBI:58044

http://identifiers.org/biomodels.db/MODEL1310110023#_a44bfa4b_b90f_4a36_8f69_5ff2d680bd35
type: Species
boundary condition: true
is encoded by: hsa:AA021081
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: _AA021081_1_r
initial concentration: NaN

metaR LEUPHELAT2tc
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaR BTNt4i
reversible: false
name: Biotin uptake (antiport)
fast: false
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110023#
reactant: MODEL1310110023#
is: SBO:0000185
product: MODEL1310110023#
kinetic law: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_92820403_a892_4cbd_a22a_17800cacd6a1
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:79717
initial amount: NaN
boundary condition: true
type: Species
is: Q9HAB8
is: SBO:0000252
name: PPCS

http://identifiers.org/biomodels.db/MODEL1310110023#_ae8ebea2_66a5_4133_bb9e_1834ea98d2c8
is: P56556
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: NDUFA6
constant: false
type: Species
is encoded by: hsa:4700

http://identifiers.org/biomodels.db/MODEL1310110023#_db6441d3_90ec_497b_8f02_c3ea52ce6e4f
initial amount: NaN
name: ND1
initial concentration: NaN
is: Q85KV6
has only substance units: false
boundary condition: true
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:4535

http://identifiers.org/biomodels.db/MODEL1310110023#_9ea92e58_8524_41f7_a812_b2142501a2ca
initial concentration: NaN
is: SBO:0000252
name: NDUFV3
boundary condition: true
constant: false
is: P56181
has only substance units: false
is encoded by: hsa:4731
type: Species
initial amount: NaN

metaR TYRTAm
is: SBO:0000176
product: MODEL1310110023#
is described by: ECO:0000269
name: tyrosine transaminase, mitochondrial
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.6.1.1
notes: GENE_ASSOCIATION: (6898.1) or (2806.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: PMID:1973834 NOTES:NCD
fast: false
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.6.1.5
reversible: true
modifier: MODEL1310110023#
type: Reaction

metaR GALNTg
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.4.1.41
reversible: false
name: GalNAc transferase, Golgi apparatus
fast: false
notes: GENE_ASSOCIATION: (26290.1) or (79695.1) or (2589.1) or (50614.1) or (8693.1) or (55568.2) or (114805.1) or (11226.1) or (117248.1) or (11227.1) or (55568.1) or (2590.1) or (51809.1) or (26290.1) or (79623.1) or (63917.1) or (2591.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.41 Confidence Level: 0 AUTHORS: PMID:10767557,PMID:12417297,PMID:12507512,PMID:12634319,PMID:15147861,PMID:9765313 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110023#
is: SBO:0000176
product: MODEL1310110023#
type: Reaction
modifier: MODEL1310110023#

metaR PI5P3K
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5295.2 and 5290.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.1) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5290.1 and 5295.3) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.137
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
product: MODEL1310110023#
name: phosphatidylinositol-5-phosphate 3-kinase
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.1.153
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.154
is version of: http://identifiers.org/ec-code/2.7.11.1
type: Reaction
is described by: ECO:0000000
fast: false

metaM fald e
is: HMDB01426
boundary condition: false
name: formaldehyde
is: CHEBI:16842
constant: false
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

metaR S23T4g
product: MODEL1310110023#
fast: false
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.99.4
is described by: ECO:0000000
kinetic law: MODEL1310110023#
type: Reaction
modifier: MODEL1310110023#
reactant: MODEL1310110023#
name: beta-galactoside alpha-2,3-sialyltransferase

metaM fol c
type: Species
name: Folate
boundary condition: false
notes: FORMULA: C19H18N7O6 CHARGE: -1
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB00121
initial amount: NaN
constant: false

metaM hexe3coa m
boundary condition: false
is: HMDB06522
constant: false
name: 3-hexenoylcoa
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
type: Species

metaR r0522
reactant: MODEL1310110023#
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110023#
fast: false
product: MODEL1310110023#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
kinetic law: MODEL1310110023#
type: Reaction
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10

metaM arachcoa c
initial amount: NaN
has only substance units: false
name: arachidyl coenzyme A
boundary condition: false
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:15527
is: HMDB04258
constant: false

metaM acnacngalgbside hs c
type: Species
name: disialyl galactosylgloboside
initial concentration: 1.0
constant: false
is: CHEBI:3338
boundary condition: false
is: SBO:0000247
is: C00036
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
has only substance units: false
is: HMDB00223
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_070e1d25_63e8_49b7_95a3_92c680ba2022
name: PANK3
is: Q9H999
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:79646
type: Species
initial concentration: NaN
initial amount: NaN
constant: false

metaR PROD2
is: SBO:0000176
notes: GENE_ASSOCIATION: (58510.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR
is version of: http://identifiers.org/ec-code/1.5.99.8
name: Proline dehydrogenase
reactant: MODEL1310110023#
reversible: false
product: MODEL1310110023#
type: Reaction
fast: false
is described by: ECO:0000254
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#

metaR r0523
reversible: false
is version of: http://identifiers.org/ec-code/1.17.4.1
is described by: ECO:0000000
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
kinetic law: MODEL1310110023#
is: SBO:0000176
modifier: MODEL1310110023#
reactant: MODEL1310110023#
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
type: Reaction
fast: false

metaR FAOXC102C101x
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_b27f0846_f93e_487c_8dbc_b342d1dc4f7b
is: P36269
type: Species
initial amount: NaN
initial concentration: NaN
name: GGT5
is encoded by: hsa:2687
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252

metaM 5pmev c
name: (R)-5-phosphonatomevalonate(3-)
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H10O7P CHARGE: -3 INCHI: InChI=1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/p-3/t6-/m1/s1
is: HMDB01343
type: Species
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN

metaR FORMCOAtx
name: formyl coa transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism see Verhoeven 11591435 and clayton 11356171 - added for peroxisomal oxidation of fatty acids NJ
fast: false
is: SBO:0000185
type: Reaction
reversible: true
product: MODEL1310110023#
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
is described by: ECO:0000000

metaM ksi pre6 g
has only substance units: false
notes: FORMULA: C107H174N7O80SX CHARGE: -2
is: HMDB00175
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: C00130
type: Species
is: CHEBI:58053
constant: false
name: keratan sulfate I biosynthesis, precursor 6
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110023#_7d942b96_4cb7_44b9_ac30_cff55bd3d0e2
has only substance units: false
is: A8K4A0
initial concentration: NaN
is encoded by: hsa:411
initial amount: NaN
boundary condition: true
constant: false
name: ARSB
is: SBO:0000252
type: Species

metaR LNLCCPT2
product: MODEL1310110023#
kinetic law: MODEL1310110023#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110023#
type: Reaction
reactant: MODEL1310110023#
fast: false
is: SBO:0000176
name: carnitine transferase
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000

metaM fol e
type: Species
boundary condition: false
notes: FORMULA: C19H18N7O6 CHARGE: -1
name: Folate
is: SBO:0000247
is: HMDB00121
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_935431e5_b51e_45b7_9eb5_3bc4079732e4
name: LGSN
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
type: Species
is encoded by: hsa:51557
initial concentration: NaN
is: Q5TDP6

metaR DESAT18 5
reversible: false
reactant: MODEL1310110023#
product: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
fast: false
name: stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)
is described by: ECO:0000269
kinetic law: MODEL1310110023#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.19.1
modifier: MODEL1310110023#

metaR DOLPMT2 Uer
is: SBO:0000176
product: MODEL1310110023#
type: Reaction
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
reversible: false
reactant: MODEL1310110023#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110023#

metaM q10 c
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
constant: false
is: HMDB01072
name: ubiquinone-10
initial amount: NaN
boundary condition: false
is: CHEBI:46245
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_60593a79_6286_4bbb_a1cd_80a898538ebc
boundary condition: true
constant: false
type: Species
has only substance units: false
name: DAD1
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1603
is: Q53G02

metaR ASPTAm
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:6930651 NOTES:NCD
reversible: true
name: aspartate transaminase
kinetic law: MODEL1310110023#
fast: false
modifier: MODEL1310110023#
is described by: ECO:0000269
product: MODEL1310110023#
reactant: MODEL1310110023#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.1

metaM fgam c
is: C04376
initial amount: NaN
notes: FORMULA: C8H13N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01281 EHMN_ABBREVIATION: C04376
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01308
type: Species
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide
constant: false
is: CHEBI:58426

metaM ksi pre35 g
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:28067
type: Species
initial concentration: 1.0
notes: FORMULA: C241H384N17O205S11X CHARGE: -12
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 35
constant: false

metaM gluside hs r
is: CHEBI:18368
name: D-glucosyl-N-acylsphingosine
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species

metaR DESAT18 4
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
name: stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.14.19.1
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110023#
product: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_d9869af2_88ec_4261_a8f3_d1a43db81f68
name: PDE8A
type: Species
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:5151
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR FAOXC160
reactant: MODEL1310110023#
is described by: ECO:0000269
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
fast: false
modifier: MODEL1310110023#
product: MODEL1310110023#
kinetic law: MODEL1310110023#
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110023#_3d46813f_a367_4c80_a78e_e2edb52bf471
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:6513
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: P11166
type: Species
name: SLC2A1

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

metaR PRISTtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ
reactant: MODEL1310110023#
fast: false
product: MODEL1310110023#
kinetic law: MODEL1310110023#
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: prist peroxisomal transport

http://identifiers.org/biomodels.db/MODEL1310110023#_6f2314ed_ba5a_4d44_aa79_1164207c0bda
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:219
boundary condition: true
initial amount: NaN
name: ALDH1B1
has only substance units: false
is: P30837
type: Species

metaR LNLCCPT1
name: carnitine O-palmitoyltransferase
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
fast: false
modifier: MODEL1310110023#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110023#
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110023#

metaR r2109
modifier: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110023#
reversible: true
reactant: MODEL1310110023#
fast: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110023#

metaM ksi pre17 g
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 17
notes: FORMULA: C157H252N11O127S5X CHARGE: -6
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:28067
type: Species
constant: false

metaR S4TASE3ly
is: SBO:0000176
modifier: MODEL1310110023#
type: Reaction
name: N-acetylgalactosamine-4-sulfatase, lysosomal
fast: false
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
reversible: true
reactant: MODEL1310110023#
product: MODEL1310110023#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.12

metaR GLNCYSNaEx
is: SBO:0000185
reversible: false
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
is described by: ECO:0000269
name: L-cysteine/L-glutamine Na-dependent exchange (Gln-L in)
product: MODEL1310110023#
type: Reaction
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_4e2d57d0_6b49_41ec_8cfb_3fc20f8c33e7
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5332
boundary condition: true
is: E2QRH8
constant: false
initial concentration: NaN
name: PLCB4
type: Species
has only substance units: false

metaR C160CPT2
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TV
reversible: false
name: C160 transport into the mitochondria
kinetic law: MODEL1310110023#
fast: false
type: Reaction
modifier: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000269
is: SBO:0000176

metaM acnacngalgbside hs g
constant: false
initial amount: NaN
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
name: disialyl galactosylgloboside
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
is: C00036
is: HMDB00223
is: CHEBI:3338

metaR r2108
type: Reaction
modifier: MODEL1310110023#
product: MODEL1310110023#
kinetic law: MODEL1310110023#
fast: false
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110023#
is: SBO:0000185

metaR ACGPID
modifier: MODEL1310110023#
reactant: MODEL1310110023#
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.5.1.89
reversible: false
notes: GENE_ASSOCIATION: (9487.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.5.1.89 Confidence Level: 4 AUTHORS: PMID:10085243,PMID:14742432 NOTES:NCD
is described by: ECO:0000269
kinetic law: MODEL1310110023#
type: Reaction
fast: false
is: SBO:0000176
name: N-acetylglucosaminylphosphatidylinositol deacetylase

metaR PTPATe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110023#
product: MODEL1310110023#
name: PTPATe
type: Reaction
fast: false
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110023#
is described by: ECO:0000134

metaR GLYtp
reactant: MODEL1310110023#
is: SBO:0000185
reversible: true
fast: false
kinetic law: MODEL1310110023#
product: MODEL1310110023#
name: glycine passive transport to peroxisome
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:TDV
is described by: ECO:0000000

metaR GALSIDEtl
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
fast: false
type: Reaction
product: MODEL1310110023#
reversible: true
name: galactocerebroside intracellular transport
is described by: ECO:0000000

metaR HSPASEly
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:12782143,PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
product: MODEL1310110023#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110023#
name: heparan sulfate proteoglycan protease, lysosome (endosome)
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110023#

metaM lald D c
name: (R)-lactaldehyde
has only substance units: false
constant: false
is: HMDB06458
is: CHEBI:17167
type: Species
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m1/s1
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaR FAOXC225C204x
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_d8845b91_b8ce_4044_87bd_8c0cfa178937
name: ESCO1
boundary condition: true
is: Q5FWF5
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:114799
constant: false
initial amount: NaN

metaM cpppg3 c
notes: FORMULA: C36H40N4O8 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01085 EHMN_ABBREVIATION: C03263
is: HMDB01261
name: Coproporphyrinogen III
is: CHEBI:57309
is: C03263
initial amount: NaN
has only substance units: false
constant: false
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110023#_8406621a_0162_45e4_913a_5a9f8b1747ba
boundary condition: true
is: P15309
has only substance units: false
is encoded by: hsa:55
name: ACPP
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN

metaM 3dphb m
has only substance units: false
is: HMDB06251
initial amount: NaN
type: Species
constant: false
boundary condition: false
notes: FORMULA: C57H85O3 CHARGE: -1 INCHI: InChI=1/C57H86O3/c1-44(2)21-12-22-45(3)23-13-24-46(4)25-14-26-47(5)27-15-28-48(6)29-16-30-49(7)31-17-32-50(8)33-18-34-51(9)35-19-36-52(10)37-20-38-53(11)39-40-54-43-55(57(59)60)41-42-56(54)58/h21,23,25,27,29,31,33,35,37,39,41-43,58H,12-20,22,24,26,28,30,32,34,36,38,40H2,1-11H3,(H,59,60)/b45-23+,46-25+,47-27+,48-29+,49-31+,50-33+,51-35+,52-37+,53-39+
initial concentration: 1.0
is: SBO:0000247
name: 3-Decaprenyl-4-hydroxybenzoate

metaR TCYNTtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
fast: false
reactant: MODEL1310110023#
type: Reaction
is: SBO:0000185
reversible: false
product: MODEL1310110023#
name: Thiocyanate transport via diffusion (mitochondrial)
kinetic law: MODEL1310110023#
is described by: ECO:0000000

metaM adp x
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:456216
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
name: ADP(3-)
is: HMDB01341

metaM cs a l
constant: false
name: chondroitin sulfate A (GalNAc4S-GlcA), free chain
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
is: HMDB02183
type: Species
initial amount: NaN
is: CHEBI:36005

metaM acnacngalgbside hs e
name: disialyl galactosylgloboside
is: C00036
is: HMDB00223
constant: false
is: CHEBI:3338
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false

metaR r1156
type: Reaction
is described by: ECO:0000000
fast: false
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
kinetic law: MODEL1310110023#
product: MODEL1310110023#
is: SBO:0000176
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
reversible: true

metaM hs deg5 l
type: Species
is: HMDB00158
notes: FORMULA: C67H97N4O86S10 CHARGE: -11
is: SBO:0000247
constant: false
initial concentration: 1.0
name: heparan sulfate, degradation product 5
initial amount: NaN
boundary condition: false
is: CHEBI:17895
has only substance units: false

metaR FAOXC161802m
reversible: false
product: MODEL1310110023#
type: Reaction
fast: false
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000269
name: Beta oxidation fatty acid
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110023#_19920e7d_cedc_44df_8ee2_0576f520ae5d
is: Q15274
name: QPRT
is: SBO:0000252
boundary condition: true
type: Species
constant: false
is encoded by: hsa:23475
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM udpacgal g
is: HMDB00304
type: Species
is: SBO:0000247
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: UDP-N-acetyl-D-galactosamine(2-)
constant: false
boundary condition: false
is: CHEBI:57847

metaR L LACt2r
type: Reaction
reversible: true
reactant: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
is described by: ECO:0000269
name: L-lactate reversible transport via proton symport
kinetic law: MODEL1310110023#
is: SBO:0000185
modifier: MODEL1310110023#
product: MODEL1310110023#

metaR 34HPPOR
modifier: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (3242.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.27 Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
name: 4-Hydroxyphenylpyruvate:oxygen oxidoreductase
product: MODEL1310110023#
fast: false
reversible: false
type: Reaction
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.13.11.27
is: SBO:0000176

metaR NICRNS
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110023#
product: MODEL1310110023#
is described by: ECO:0000000
fast: false
type: Reaction
name: NICRNS
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:no gene or enzyme name known (in kegg) but reaction has to take place. IT
reactant: MODEL1310110023#

metaR HACD9m
product: MODEL1310110023#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
type: Reaction
kinetic law: MODEL1310110023#
fast: false
is described by: ECO:0000134
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
is: SBO:0000176
modifier: MODEL1310110023#

metaR DNDPt23m
modifier: MODEL1310110023#
reversible: false
reactant: MODEL1310110023#
fast: false
type: Reaction
kinetic law: MODEL1310110023#
is: SBO:0000185
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dTDP transport via dGTP antiport
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110023#_2b82e98a_bcc7_47e8_a08f_b60a3b87507c
constant: false
initial concentration: NaN
is: P32321
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:1635
type: Species
initial amount: NaN
name: DCTD

http://identifiers.org/biomodels.db/MODEL1310110023#_21e30ae1_8c2e_49cb_ba25_cfe334d543a2
initial amount: NaN
is encoded by: hsa:114
initial concentration: NaN
has only substance units: false
is: Q4F7X0
name: ADCY8
type: Species
is: SBO:0000252
constant: false
boundary condition: true

metaR PNTK
modifier: MODEL1310110023#
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110023#
kinetic law: MODEL1310110023#
type: Reaction
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.1.33
notes: GENE_ASSOCIATION: (79646.1) or (80025.2) or (53354.1) or (53354.3) or (80025.1) or (53354.2) or (80025.3) or (80025.4) or (55229.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: pantothenate kinase
fast: false
reversible: false

metaR GGH 7THFe
reactant: MODEL1310110023#
modifier: MODEL1310110023#
name: Gamma-glutamyl hydrolase (7THF), extracellular
product: MODEL1310110023#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
fast: false
kinetic law: MODEL1310110023#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.19.9

metaR r2105
product: MODEL1310110023#
fast: false
kinetic law: MODEL1310110023#
type: Reaction
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110023#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reversible: true
is: SBO:0000185

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

metaR FAOXC225C226x
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)x
type: Reaction

metaM akg m
is: C00026
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:16810
boundary condition: false
has only substance units: false
is: HMDB00208
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
initial amount: NaN
name: 2-Oxoglutarate

metaR PAIL4P HStn
reactant: MODEL1310110023#
product: MODEL1310110023#
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)
fast: false
is described by: ECO:0000000
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
kinetic law: MODEL1310110023#
type: Reaction

metaR THYMt
name: thymine reversible transport via facilated diffusion
modifier: MODEL1310110023#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110023#

metaR GPIDAer
type: Reaction
reactant: MODEL1310110023#
name: glycophosphatidylinositol (GPI) deacylase, endoplasmic reticulum
fast: false
kinetic law: MODEL1310110023#
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (80055.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14734546 NOTES:NCD
modifier: MODEL1310110023#
reversible: false
is: SBO:0000176
is described by: ECO:0000000

metaM nadp c
is: HMDB00217
is: SBO:0000247
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
boundary condition: false
name: Nicotinamide adenine dinucleotide phosphate
is: CHEBI:58349
initial concentration: 1.0
type: Species
is: C00006
constant: false
has only substance units: false
initial amount: NaN

metaR r1154
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 1.2.7.2 Confidence Level: 0 AUTHORS: PMID:2649080,PMID:283398,PMID:3718468,PMID:9381974 NOTES:
kinetic law: MODEL1310110023#
is: SBO:0000176
product: MODEL1310110023#
reactant: MODEL1310110023#
name: EC:1.2.7.2
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_6393631b_d48f_452e_b768_136ace31a25a
is encoded by: hsa:412
has only substance units: false
boundary condition: true
name: STS
type: Species
constant: false
initial amount: NaN
is: P08842
initial concentration: NaN
is: SBO:0000252

metaR ARGtiDF
fast: false
is: SBO:0000185
product: MODEL1310110023#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (6541.1) or (6542.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
reactant: MODEL1310110023#
reversible: false
name: L-arginine transport via diffusion (extracellular to cytosol)
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#

metaR SQLSr
kinetic law: MODEL1310110023#
is described by: ECO:0000134
reactant: MODEL1310110023#
is: SBO:0000176
modifier: MODEL1310110023#
name: Squalene synthase
product: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ
reversible: false
is version of: http://identifiers.org/ec-code/2.5.1.21
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_388701cf_a5b3_468b_b927_af0b60a25832
constant: false
boundary condition: true
is: P28329
type: Species
has only substance units: false
name: CHAT
initial amount: NaN
is encoded by: hsa:1103
initial concentration: NaN
is: SBO:0000252

metaR PSSA1 hs
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.7.8.29
type: Reaction
fast: false
modifier: MODEL1310110023#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9791.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylcholine as substrate NJ
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
product: MODEL1310110023#
name: Phosphatidylserine synthase homo sapiens

http://identifiers.org/biomodels.db/MODEL1310110023#_2fd10928_4eab_4434_a77e_405f16391453
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:5150
constant: false
is: SBO:0000252
name: PDE7A

http://identifiers.org/biomodels.db/MODEL1310110023#_8cb3465b_c24b_4f94_9218_f3eb49bb9573
has only substance units: false
is encoded by: hsa:374291
boundary condition: true
is: O75251
type: Species
name: NDUFS7
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110023#_3557a4a7_e9f9_477f_ab67_e7210988dae9
is: O43916
is: SBO:0000252
name: CHST1
is encoded by: hsa:8534
type: Species
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR RE1519M
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110023#
type: Reaction
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.3.99.13
reactant: MODEL1310110023#
name: RE1519
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
fast: false
product: MODEL1310110023#

metaM leuktrB4 c
is: SBO:0000247
name: leukotriene B4(1-)
boundary condition: false
type: Species
is: HMDB01085
is: CHEBI:57461
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165

metaR r2104
reactant: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
kinetic law: MODEL1310110023#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
modifier: MODEL1310110023#
is described by: ECO:0000000
product: MODEL1310110023#

metaR RE3245C
reactant: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton
is described by: ECO:0000000
product: MODEL1310110023#
reversible: true
name: RE3245
kinetic law: MODEL1310110023#
fast: false
is: SBO:0000176

metaM h2o2 c
name: Hydrogen peroxide
is: CHEBI:16240
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
is: HMDB03125
is: SBO:0000247
is: C00027
constant: false
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110023#_3e05b673_d1dc_4b08_abc5_2c3a707e0638
has only substance units: false
name: NAGA
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: P17050
constant: false
is encoded by: hsa:4668
is: SBO:0000252

metaR CYSASNNaEx
reversible: false
type: Reaction
modifier: MODEL1310110023#
fast: false
product: MODEL1310110023#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110023#
name: L-cysteine/L-asparagine Na-dependent exchange (Cys-L in)
is described by: ECO:0000269
kinetic law: MODEL1310110023#

metaM hs deg15 l
is: SBO:0000247
constant: false
name: heparan sulfate, degradation product 15
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:16126
notes: FORMULA: C49H71N2O57S5 CHARGE: -7
initial concentration: 1.0

metaR r2107
product: MODEL1310110023#
fast: false
type: Reaction
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000000
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true

metaR THRGLYexR
name: L-threonine/glycine reversible exchange
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110023#
type: Reaction
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
is described by: ECO:0000304

metaR GALSIDEtg
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
reactant: MODEL1310110023#
is described by: ECO:0000000
product: MODEL1310110023#
name: galactocerebroside intracellular transport
fast: false
type: Reaction
kinetic law: MODEL1310110023#

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

metaR HIStN1
reversible: true
modifier: MODEL1310110023#
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is: SBO:0000185
reactant: MODEL1310110023#
is described by: ECO:0000269
type: Reaction
name: Histidine transport (Na, H coupled)
kinetic law: MODEL1310110023#
fast: false

metaR GLUPRT
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.4.2.14
modifier: MODEL1310110023#
is: SBO:0000176
reactant: MODEL1310110023#
fast: false
type: Reaction
is described by: ECO:0000269
name: glutamine phosphoribosyldiphosphate amidotransferase
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110023#_02614e99_fefd_4740_bc27_3583bc27803a
name: CYP27A1
type: Species
initial amount: NaN
is: Q02318
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:1593
boundary condition: true
has only substance units: false

metaR RE3627M
name: RE3627
is: SBO:0000176
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110023#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
type: Reaction
product: MODEL1310110023#
reactant: MODEL1310110023#
reversible: true
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:

metaR ADNt
modifier: MODEL1310110023#
product: MODEL1310110023#
kinetic law: MODEL1310110023#
name: adenosine facilated transport in cytosol
type: Reaction
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
is described by: ECO:0000269
reversible: true
is: SBO:0000185
fast: false

metaR 1PPDCRp
kinetic law: MODEL1310110023#
type: Reaction
fast: false
name: delta1-piperideine-2-carboxylate reductase, perixosomal
is described by: ECO:0000000
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:MM
reactant: MODEL1310110023#
reversible: false
is: SBO:0000176

metaM udpacgal c
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:57847
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
name: UDP-N-acetyl-D-galactosamine(2-)
is: HMDB00304
has only substance units: false

metaR VALt5m
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
type: Reaction
name: Valine reversible mitochondrial transport
is described by: ECO:0000000
fast: false
product: MODEL1310110023#

metaR r2106
type: Reaction
is: SBO:0000185
product: MODEL1310110023#
modifier: MODEL1310110023#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110023#
reversible: true
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM ksii core2 pre5 g
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:58053
name: keratan sulfate II biosynthesis, precursor 5
type: Species
is: C00130
is: HMDB00175
notes: FORMULA: C61H99N5O43X CHARGE: -1

metaM 4mlacac c
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1- HEPATONET_1.0_ABBREVIATION: HC00635 EHMN_ABBREVIATION: C01036
has only substance units: false
is: HMDB02052
constant: false
type: Species
name: 4-maleylacetoacetate
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17105
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_718dd6f6_679c_43ac_b3ae_949737cd2bf7
is encoded by: hsa:U37519
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
name: _U37519_1_c
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_4ce807ee_84e5_43e8_a394_d09b0b8e7afb
has only substance units: false
name: ACSS1
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
is: Q9NUB1
type: Species
boundary condition: true
is encoded by: hsa:84532

http://identifiers.org/biomodels.db/MODEL1310110023#_f2219c49_64fa_479b_8ca0_3e7f6fadfc87
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:4166
has only substance units: false
name: CHST6
is: SBO:0000252
constant: false
initial amount: NaN
is: Q9GZX3

metaM ksi deg17 l
name: keratan sulfate I, degradation product 17
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:12936
initial amount: NaN
notes: FORMULA: C152H245N10O132S7 CHARGE: -7
is: HMDB00143
boundary condition: false
constant: false

metaR ASNCYSNaEx
name: L-cysteine/L-asparagine Na-dependent exchange (Asn-L in)
modifier: MODEL1310110023#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
product: MODEL1310110023#
is: SBO:0000185
kinetic law: MODEL1310110023#
fast: false
reactant: MODEL1310110023#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_e43e3002_26eb_4299_96be_6c9f267aa2b1
name: PIGQ
type: Species
initial amount: NaN
boundary condition: true
is: Q9BRB3
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:9091

metaR FAOXC225C204m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)m
type: Reaction

metaM m7masnC g
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB00968
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform C (protein)
has only substance units: false
notes: FORMULA: C64H107N2O50X CHARGE: 0
is: SBO:0000247
is: CHEBI:58282
constant: false
type: Species

metaM idp c
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:58280
initial amount: NaN
initial concentration: 1.0
name: IDP(3-)
constant: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
has only substance units: false
is: HMDB03335

ORG:
  orgname: University of Manchester
n:
  given: Neil
  family: Swainston

metaR EX 4mptnl LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-methylpentanal Exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_c570f8e0_7e7e_4958_8f72_8cbd30ec714b
constant: false
is: O95907
initial amount: NaN
type: Species
is encoded by: hsa:23539
boundary condition: true
name: SLC16A8
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaM adp n
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB01341
name: ADP(3-)
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:456216

metaR PRFGS
reactant: MODEL1310110023#
product: MODEL1310110023#
name: phosphoribosylformylglycinamidine synthase
is version of: http://identifiers.org/ec-code/6.3.5.3
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
type: Reaction
fast: false
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (5198.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269

metaR r2101
is: SBO:0000185
modifier: MODEL1310110023#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110023#
type: Reaction
reactant: MODEL1310110023#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110023#
is described by: ECO:0000000

metaR GluForTx
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Histidine metabolism EC Number: 2.1.2.5 Confidence Level: 4 AUTHORS: PMID:12815595 NOTES:SAB
type: Reaction
fast: false
name: Glutamate formimidoyltransferase
is described by: ECO:0000269
reactant: MODEL1310110023#
reversible: false
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.1.2.5
is: SBO:0000176
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_3e394f23_13de_44d9_b72d_9871d692f9e1
is: Q5JAM2
is: SBO:0000252
constant: false
boundary condition: true
name: ALAS1
is encoded by: hsa:211
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_a46e6a5e_9198_4af6_9fd5_5a80059e8764
has only substance units: false
is: Q8IWX5
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:130367
name: SGPP2

metaR DGULND
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110023#
reversible: true
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
name: dehydro-L-gulonate decarboxylase
reactant: MODEL1310110023#
fast: false
type: Reaction

metaM prostgh2 e
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
initial amount: NaN
name: prostaglandin H2(1-)
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
is: HMDB01381
type: Species
is: SBO:0000247
is: CHEBI:57405

metaR HISSNAT5tc
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR CYTK13n
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110023#
type: Reaction
kinetic law: MODEL1310110023#
product: MODEL1310110023#
fast: false
is described by: ECO:0000269
name: cytidylate kinase (dCMP,dATP),nuclear
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110023#_b3d465a2_34da_492c_ab38_7752c8ddf77e
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: CPT2
has only substance units: false
is: SBO:0000252
is: P23786
constant: false
is encoded by: hsa:1376
type: Species

metaR EX phe L LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-phenylalanine
type: Reaction

metaR r2100
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110023#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110023#
modifier: MODEL1310110023#
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110023#

metaR RTOTAL3t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
product: MODEL1310110023#
fast: false
reversible: true
reactant: MODEL1310110023#
name: RTOTAL3 transport
kinetic law: MODEL1310110023#
type: Reaction
is: SBO:0000185

metaM adp m
is: HMDB01341
constant: false
type: Species
is: CHEBI:456216
is: SBO:0000247
name: ADP
has only substance units: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3310
boundary condition: false
is: C00008
initial amount: NaN

metaM lnlncg e
name: gamma-linolenate
is: CHEBI:32391
is: SBO:0000247
initial amount: NaN
is: HMDB03073
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
constant: false
has only substance units: false

metaM cs e deg7 l
boundary condition: false
has only substance units: false
is: SBO:0000247
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 7
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15936
notes: FORMULA: C23H35O27S2 CHARGE: -3

http://identifiers.org/biomodels.db/MODEL1310110023#_576369a6_a034_477f_ad90_8c94376da4d7
name: PANK4
has only substance units: false
is: Q9NVE7
initial amount: NaN
constant: false
is encoded by: hsa:55229
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110023#_9cca28c3_71d1_41f8_96dc_81e50ab783b2
constant: false
has only substance units: false
boundary condition: true
name: GPX7
type: Species
initial concentration: NaN
is: Q96SL4
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2882

metaR r2103
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
type: Reaction
modifier: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000185
kinetic law: MODEL1310110023#
product: MODEL1310110023#

metaR CORE2GTg
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.102
reactant: MODEL1310110023#
modifier: MODEL1310110023#
is: SBO:0000176
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (9245.1) or (2650.1) or (51301.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:10753916,PMID:9915862 NOTES:NCD
product: MODEL1310110023#
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus

metaR DMHPTCRNCPT2
reactant: MODEL1310110023#
name: 2,6 dimethylheptanoly CoA carnitine transferase
product: MODEL1310110023#
kinetic law: MODEL1310110023#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9819701 NOTES:made reversible since Keq ~ 0.6. dmhptcoa is a special case because its biochemical fate has not be elucidated. NJ
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_7efaa6cd_7e1b_43c9_9b65_38fc3d2503f9
is encoded by: hsa:D87002
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
name: _D87002_1_e
type: Species
is: SBO:0000252

metaR ACGALK
reactant: MODEL1310110023#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
kinetic law: MODEL1310110023#
reversible: false
is: SBO:0000176
fast: false
name: N-acetylgalactosamine kinase
product: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_74c0a2f5_3b9b_4e6d_a921_edf94ebc5c2c
is encoded by: hsa:9962
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
name: SLC23A2
initial concentration: NaN
boundary condition: true

metaM prostgh2 c
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
name: prostaglandin H2(1-)
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
is: HMDB01381
type: Species
is: CHEBI:57405
is: SBO:0000247

metaR GPIAT
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110023#
type: Reaction
fast: false
kinetic law: MODEL1310110023#
is: SBO:0000176
notes: GENE_ASSOCIATION: (284098.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14517336 NOTES:EC 2.3.-.- NCD
product: MODEL1310110023#
reactant: MODEL1310110023#
name: glucosaminylphosphatidyl inositol acetyltransferase

metaR TCHOLAtx
product: MODEL1310110023#
reversible: true
reactant: MODEL1310110023#
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
kinetic law: MODEL1310110023#
name: bile acid intracellular transport
is: SBO:0000185

metaM h2o2 e
initial concentration: 1.0
is: CHEBI:16240
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
constant: false
is: HMDB03125
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: hydrogen peroxide
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_1f1aa934_5dfd_45ad_98df_18694ba81b22
constant: false
boundary condition: true
is: SBO:0000297
name: PDE6A:PDE6C:PDE6D:PDE6G:PDE6B
initial amount: NaN
has part: O43924
has only substance units: false
has part: P18545
type: Species
is encoded by: hsa:5147
initial concentration: NaN
is encoded by: hsa:5148

metaR r2102
kinetic law: MODEL1310110023#
product: MODEL1310110023#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reversible: true
modifier: MODEL1310110023#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110023#

MODEL1310110023
species: metaM dgdp c
reaction: metaR r1576
reaction: metaR r0552
species: metaM prpp e
reaction: metaR HSAT3ly
reaction: metaR HSD3A2r
reaction: metaR r0340
species: metaM prpp c
species: metaM leuktrA4 r
reaction: metaR FAOXC7C5m
species: metaM ach c
reaction: metaR r1591
species: metaM hdca l
species: metaM retinol 9 cis c
reaction: metaR EX pglyc hs LPAREN e RPAREN
reaction: metaR PROt2r
species: metaM HC02217 e
species: metaM HC00342 m
reaction: metaR EX dtdp LPAREN e RPAREN
species: metaM tcynt c
reaction: metaR FACOAL2042
reaction: metaR SPODMx
reaction: metaR RE1807C
reaction: metaR r1622
species: metaM phyt2ohcoa x
reaction: metaR MELATNOX
reaction: metaR r0393
species: metaM ksii core4 e
species: metaM dopasf e
species: metaM fuc1p L c
reaction: metaR r0842
species: metaM hexe3coa m
reaction: metaR CREATt4 2 r
reaction: metaR EX idour LPAREN e RPAREN
reaction: metaR BILIRUBt2
reaction: metaR BTNDe
species: metaM lnlccoa m
reaction: metaR HPDCAt
reaction: metaR NDP7ex
reaction: metaR PDE4
reaction: metaR ABUTD
species: metaM HC02216 c
reaction: metaR GGH 10FTHF7GLUe
species: metaM retn e
reaction: metaR IMPD
reaction: metaR r1637
reaction: metaR UDPtl
reaction: metaR FAOXC164GC163m
species: metaM m2emgacpail hs r
species: metaM HC02213 e
reaction: metaR r2354
species: metaM dhdascb e
reaction: metaR GLCNACASE3ly
reaction: metaR S6T9g
reaction: metaR FACOAL181i
reaction: metaR r1652
species: metaM nicrns c
species: metaM damp c
reaction: metaR NACHEX22ly
species: metaM h n
reaction: metaR r1156
reaction: metaR PROSTGI2tr
reaction: metaR RE1534M
species: metaM utp c
species: metaM 12ppd R c
species: metaM ac c
species: metaM dmnoncoa m
species: metaM l2n2m2mn l
species: metaM tdec4ecoa m
species: metaM cspg e l
reaction: metaR r0963
reaction: metaR EX HC00229 LPAREN e RPAREN
reaction: metaR AHCYStr
reaction: metaR PI34P5K
reaction: metaR GLYCTDle
reaction: metaR DM pmtcoa LPAREN r RPAREN
species: metaM glx x
species: metaM octe5coa m
reaction: metaR DCSPTN1CPT2
reaction: metaR r2140

http://identifiers.org/biomodels.db/MODEL1310110023#_9cb5635f_aee4_46d7_aa4d_3c38c67050cd
name: TXNRD2
has only substance units: false
is encoded by: hsa:10587
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
type: Species

metaR M8MASNterg
type: Reaction
kinetic law: MODEL1310110023#
product: MODEL1310110023#
fast: false
reactant: MODEL1310110023#
is: SBO:0000185
is described by: ECO:0000000
reversible: false
name: m8masn transport from ER to Golgi apparatus
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:11007802 NOTES:NCD

metaM rbt c
is: CHEBI:15963
boundary condition: false
name: D-ribitol
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
type: Species
constant: false
is: HMDB00508
is: SBO:0000247

metaM leuktrB4 e
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
is: HMDB01085
name: leukotriene B4(1-)
type: Species
is: CHEBI:57461
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaR FAOXC101C102m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)m
type: Reaction

metaR EX gtp LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GTP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_3ae61e73_0601_4d6e_a0f2_0ddad43dfce3
name: DPM2
has only substance units: false
constant: false
initial amount: NaN
is: O94777
type: Species
boundary condition: true
is encoded by: hsa:8818
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_5f93bd15_d0fb_42a6_9d8c_9f9bb24a6213
constant: false
is: Q9GZS9
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
name: CHST5
is encoded by: hsa:23563

metaR KSII CORE2t
product: MODEL1310110023#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110023#
name: keratan sulfate II (core2) transport, golgi to extracellular
is described by: ECO:0000000
reversible: false

W3 CDTF: Wed Aug 29 23:38:35 BST 2012

metaM adp r
constant: false
type: Species
name: ADP(3-)
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB01341
is: CHEBI:456216
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110023#_009076d7_97f9_4d5b_b5c4_d8c66e28cc2f
initial amount: NaN
boundary condition: true
is encoded by: hsa:8527
name: DGKD
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species

metaM ksi pre20 g
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 20
constant: false
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:28067
notes: FORMULA: C171H274N12O140S6X CHARGE: -7

metaR r0963
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
type: Reaction
reversible: false
fast: false
is described by: ECO:0000000
product: MODEL1310110023#
kinetic law: MODEL1310110023#
name: Facilitated diffusion
reactant: MODEL1310110023#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110023#_7a3a5bbc_c4ad_4f2d_8ca3_8503accd10dc
name: PIGM
is: Q9H3S5
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:93183
type: Species
constant: false
has only substance units: false
initial amount: NaN

metaM ksi pre5 g
is: SBO:0000247
notes: FORMULA: C101H164N7O75SX CHARGE: -2
initial concentration: 1.0
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 5
constant: false
is: CHEBI:28067
type: Species
initial amount: NaN
boundary condition: false

metaM h2o2 m
boundary condition: false
has only substance units: false
is: CHEBI:16240
initial amount: NaN
constant: false
initial concentration: 1.0
name: Hydrogen peroxide
is: SBO:0000247
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
type: Species
is: HMDB03125
is: C00027

metaR FAOXC123m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_d84b43be_4796_44a6_8786_01964e3f6a32
boundary condition: true
type: Species
constant: false
is: O75489
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4722
name: NDUFS3

metaM zymst r
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437
is: HMDB06271
has only substance units: false
is: CHEBI:18252
name: zymosterol
type: Species
initial concentration: 1.0
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110023#_182af463_058a_498a_ba37_75dd8fd12fb2
initial concentration: NaN
is: SBO:0000252
name: ADK
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:132
type: Species
is: P55263
constant: false

metaR LYStiDF
name: L-lysine transport via diffusion (extracellular to cytosol)
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110023#
type: Reaction
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
reversible: false
fast: false
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (6541.1) or (6542.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB

metaR NADPtru
is described by: ECO:0000000
type: Reaction
product: MODEL1310110023#
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
name: NADP transporter, endoplasmic reticulum
reversible: false
is: SBO:0000185
reactant: MODEL1310110023#
fast: false

metaR EX dhf LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 7,8-Dihydrofolate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_34148152_fea7_4ca6_8554_a9a9f8f653d4
constant: false
is encoded by: hsa:1808
initial amount: NaN
is: B4DR31
has only substance units: false
is: SBO:0000252
name: DPYSL2
boundary condition: true
initial concentration: NaN
type: Species

W3 CDTF: Wed Aug 29 23:38:35 BST 2012

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

metaM itp c
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
is: HMDB00189
is: SBO:0000247
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
is: CHEBI:57614
initial concentration: 1.0
constant: false
name: ITP(3-)

metaM akg c
is: HMDB00208
name: 2-Oxoglutarate
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
initial amount: NaN
is: SBO:0000247
is: CHEBI:16810
is: C00026
boundary condition: false
has only substance units: false
constant: false
type: Species
initial concentration: 1.0

metaR GALASE9ly
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
is: SBO:0000176
name: beta-galactosidase, lysosomal
product: MODEL1310110023#

metaM 5eipencoa m
is: SBO:0000247
is: HMDB02288
type: Species
initial amount: NaN
name: 5,8,11,14,17-eicosapentenoylcoa
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C41H60N7O17P3S CHARGE: -4
boundary condition: false

metaM mlthf m
initial concentration: 1.0
is: C00143
type: Species
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
is: SBO:0000247
is: HMDB01533
boundary condition: false
name: 5,10-Methylenetetrahydrofolate
is: CHEBI:15636

http://identifiers.org/biomodels.db/MODEL1310110023#_0127f1ea_a743_4e08_9d4a_829f3a69f46f
name: _AF116616_1_m
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:AF116616
initial concentration: NaN

metaM m6mpdol U r
notes: FORMULA: C1605H2640N20O520P20 CHARGE: -20
is: CHEBI:37635
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: (alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
type: Species
boundary condition: false
has only substance units: false
constant: false

metaM m8mpdol U r
has only substance units: false
name: (alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:59093
initial amount: NaN
notes: FORMULA: C1725H2840N20O620P20 CHARGE: -20 INCHI: InChI=1S/C95H162N2O62P2/c1-34(2)13-9-14-35(3)15-10-16-36(4)17-11-18-37(5)19-12-20-38(6)21-22-138-160(132,133)159-161(134,135)158-86-53(97-40(8)108)64(119)77(49(31-106)147-86)150-85-52(96-39(7)107)63(118)78(48(30-105)146-85)151-91-76(131)80(153-94-84(71(126)60(115)46(28-103)144-94)157-95-83(70(125)59(114)47(29-104)145-95)156-90-74(129)67(122)56(111)43(25-100)141-90)62(117)51(149-91)32-136-87-75(130)79(152-93-82(69(124)58(113)45(27-102)143-93)155-89-73(128)66(121)55(110)42(24-99)140-89)61(116)50(148-87)33-137-92-81(68(123)57(112)44(26-101)142-92)154-88-72(127)65(120)54(109)41(23-98)139-88/h13,15,17,19,38,41-95,98-106,109-131H,9-12,14,16,18,20-33H2,1-8H3,(H,96,107)(H,97,108)(H,132,133)(H,134,135)/b35-15+,36-17+,37-19+/t38?,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77-,78-,79+,80+,81+,82+,83+,84+,85+,86-,87+,88-,89-,90-,91+,92+,93-,94-,95-/m1/s1

metaR FAOXC101x
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)x
type: Reaction

metaM dcacoa c
initial concentration: 1.0
boundary condition: false
name: Decanoyl-CoA (n-C10:0CoA)
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
has only substance units: false
is: CHEBI:61430
constant: false
is: HMDB06404
is: C05274
type: Species
initial amount: NaN
is: SBO:0000247

metaM ksi deg32 l
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
name: keratan sulfate I, degradation product 32
initial amount: NaN
notes: FORMULA: C82H135N5O67S2 CHARGE: -2
is: HMDB00143
is: CHEBI:12936

W3 CDTF: Wed Aug 29 23:38:36 BST 2012

metaM acgpail hs c
notes: FORMULA: C17H29NO14PFULLRCO2FULLR2CO2 CHARGE: -1 EHMN_ABBREVIATION: C01288
constant: false
initial amount: NaN
is: CHEBI:57265
is: SBO:0000247
name: 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(1-)
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species

metaR r0739
reversible: true
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: PMID:5487878,PMID:6338006,PMID:6379302 NOTES:
fast: false
name: alcohol dehydrogenase Bile acid biosynthesis EC:1.1.1.1
reactant: MODEL1310110023#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110023#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110023#_e8a45b6e_956e_4d33_a243_05086f6a141d
initial amount: NaN
name: CMAS
has only substance units: false
is: Q8NFW8
is encoded by: hsa:55907
constant: false
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaR DHCHOLESTANATEtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
type: Reaction
reactant: MODEL1310110023#
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110023#
kinetic law: MODEL1310110023#
is described by: ECO:0000000
name: lipid, flip-flop intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110023#_5ce71191_a726_400c_8f4d_6d57da789d01
is: SBO:0000252
constant: false
name: PIGG
initial amount: NaN
is: Q8NCI4
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:54872
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_12d1e913_35d7_4b8a_bf7d_25c797c2ecb3
initial amount: NaN
boundary condition: true
name: ALDH9A1
type: Species
is: P49189
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:223

metaM 6dhf e
has only substance units: false
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
type: Species
boundary condition: false
initial amount: NaN
is: HMDB06563
is: SBO:0000247
constant: false
initial concentration: 1.0
name: hexaglutamyl folate (DHF)

http://identifiers.org/biomodels.db/MODEL1310110023#_cf02c3b8_9004_4844_a7a0_25c1b0d36498
initial concentration: NaN
is: Q96KJ9
is encoded by: hsa:84701
boundary condition: true
type: Species
constant: false
has only substance units: false
name: COX4I2
is: SBO:0000252
initial amount: NaN

metaR sink pre prot LPAREN r RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycophosphatidylinositol (GPI)-anchored protein precursor sink
type: Reaction

metaR THFtm
product: MODEL1310110023#
type: Reaction
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
kinetic law: MODEL1310110023#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110023#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_208b407c_ae7e_4f42_9e15_4e0a6d474417
constant: false
initial concentration: NaN
is encoded by: hsa:5335
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: PLCG1
is: Q9UFY1

metaM xol7ah2al c
is: CHEBI:27428
constant: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
is: HMDB06894
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
is: SBO:0000247
has only substance units: false

metaM akg e
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
is: CHEBI:16810
name: 2-oxoglutarate(2-)
has only substance units: false
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: SBO:0000247
is: HMDB00208
initial amount: NaN

metaR PRDX
is: SBO:0000176
modifier: MODEL1310110023#
type: Reaction
reactant: MODEL1310110023#
product: MODEL1310110023#
kinetic law: MODEL1310110023#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.11.1.7
name: Peroxidase (multiple substrates)
notes: GENE_ASSOCIATION: (8288.1) SUBSYSTEM: Miscellaneous EC Number: 1.11.1.7 Confidence Level: 0 AUTHORS: PMID:10464338 NOTES:RS/TV (6/3/05) Peroxidases can act on a variety of substrates which are oxidized, not just methanol.
fast: false

metaM udpacgal l
initial concentration: 1.0
constant: false
type: Species
name: UDP-N-acetyl-D-galactosamine(2-)
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
boundary condition: false
is: SBO:0000247
is: CHEBI:57847
has only substance units: false
is: HMDB00304
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_f7b751a8_811b_4650_9267_6d9a1b536efe
type: Species
is: Q6IB80
is: SBO:0000252
constant: false
initial amount: NaN
name: NDUFB3
initial concentration: NaN
is encoded by: hsa:4709
has only substance units: false
boundary condition: true

W3 CDTF: Wed Aug 29 23:38:36 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110023#_a1367011_f719_4cf5_9bf9_5fcefb49b1cf
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:AI769281
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
name: _AI769281_1_e

metaR GALt2 2
reversible: true
type: Reaction
is described by: ECO:0000269
fast: false
modifier: MODEL1310110023#
name: D-galactose transport via proton symport
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:
is: SBO:0000185
product: MODEL1310110023#
reactant: MODEL1310110023#

metaM ksii core4 pre9 g
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C83H133N7O64S2X CHARGE: -3
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:28067
name: keratan sulfate II biosynthesis, precursor 9
initial amount: NaN

metaR r0960
fast: false
reactant: MODEL1310110023#
product: MODEL1310110023#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
kinetic law: MODEL1310110023#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1

metaM HC01231 c
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
has only substance units: false
is: SBO:0000247
type: Species
name: N-[(R)-pantothenoyl]-L-cysteinate
is: CHEBI:58480
boundary condition: false
constant: false

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

metaM cspg a l
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
constant: false
type: Species
is: SBO:0000247
is: HMDB02183
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:36005
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_8c6ca283_e22b_47d7_ab99_d6093875d7bb
type: Species
name: ACAA1
initial concentration: NaN
is: Q96CA6
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:30

metaM ksii core2 pre10 g
constant: false
type: Species
name: keratan sulfate II biosynthesis, precursor 10
is: CHEBI:28067
boundary condition: false
has only substance units: false
notes: FORMULA: C81H130N6O64S2X CHARGE: -3
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaM gluside hs c
is: CHEBI:18368
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
has only substance units: false
constant: false
name: D-glucosyl-N-acylsphingosine

metaM lnlncg c
constant: false
name: gamma-linolenate
is: CHEBI:32391
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB03073
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_9c6babb9_4955_4357_84a8_f75f4c76b9c9
is encoded by: hsa:2679
has only substance units: false
initial concentration: NaN
name: GGT3P
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
type: Species

metaR CYANt
is: SBO:0000185
is described by: ECO:0000000
name: Cyanide transport via diffusion (extracellular to cytosol)
reactant: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM
kinetic law: MODEL1310110023#
reversible: true
type: Reaction
product: MODEL1310110023#

metaM CE2432 m
is: SBO:0000247
is: CHEBI:57795
initial concentration: 1.0
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
constant: false
type: Species
has only substance units: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_1169e675_a6e9_4241_bca2_3c5662b7b0c8
boundary condition: true
name: _AA977580_1_c
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AA977580
constant: false
initial concentration: NaN

metaR EX malt LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltose exchange
type: Reaction

metaR r1812
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110023#
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110023#
product: MODEL1310110023#
is described by: ECO:0000000
reactant: MODEL1310110023#
reversible: false
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110023#_82bc1b0e_889b_47e6_9249_d152dc465174
is: SBO:0000252
boundary condition: true
constant: false
is: C9JFZ1
initial amount: NaN
type: Species
initial concentration: NaN
name: SYNJ1
has only substance units: false
is encoded by: hsa:8867

metaR r0512
reactant: MODEL1310110023#
reversible: true
is described by: ECO:0000000
product: MODEL1310110023#
fast: false
is: SBO:0000176
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
type: Reaction
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.17.4.1

http://identifiers.org/biomodels.db/MODEL1310110023#_30568dfe_4d76_4d45_a7c4_6f6021d39016
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:57835
name: SLC4A5
boundary condition: true
is: Q9BY07
type: Species
has only substance units: false

metaM r5p c
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:18189
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB00618
name: alpha-D-Ribose 5-phosphate
is: C00117
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
constant: false

metaR r0734
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110023#
kinetic law: MODEL1310110023#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reactant: MODEL1310110023#
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
fast: false

metaR AG13T13g
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
product: MODEL1310110023#
fast: false
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false

metaR DUTPDPn
is: SBO:0000176
type: Reaction
reversible: false
modifier: MODEL1310110023#
product: MODEL1310110023#
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (1854.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.23 Confidence Level: 4 AUTHORS: PMID:12799180,PMID:8631816,PMID:9070952 NOTES:
name: dUTP diphosphatase, nuclear
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.1.23
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_dc7aeb67_ee3a_4386_9746_7010ce9634b8
boundary condition: true
is: P16930
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2184
type: Species
constant: false
name: FAH

metaR r0400
type: Reaction
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
reversible: true
reactant: MODEL1310110023#
is described by: ECO:0000000
modifier: MODEL1310110023#
fast: false
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.2.4.4
is: SBO:0000176
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110023#_d3c28125_008a_410c_9698_738a9c4b6db3
initial amount: NaN
is: P43251
name: BTD
is encoded by: hsa:686
initial concentration: NaN
constant: false
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_bc0db0ff_52fe_4639_a955_cbd02f2c59ee
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
is: P48728
is: SBO:0000252
is encoded by: hsa:275
type: Species
name: AMT
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_be1d1866_060e_4538_be43_a788ef73139b
is encoded by: hsa:NOS2A
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
name: _NOS2A_1_e
constant: false
is: SBO:0000252

metaR r0735
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
product: MODEL1310110023#
kinetic law: MODEL1310110023#
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110023#
is: SBO:0000176
modifier: MODEL1310110023#

metaR O2t
is: SBO:0000185
reactant: MODEL1310110023#
product: MODEL1310110023#
is described by: ECO:0000000
name: o2 transport (diffusion)
type: Reaction
kinetic law: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
reversible: true

metaM thexddcoa m
constant: false
name: trans7,10-hexadecadienoylcoa
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C37H58N7O17P3S CHARGE: -4
initial concentration: 1.0
type: Species
is: HMDB02288
initial amount: NaN

metaM adp e
is: CHEBI:456216
is: SBO:0000247
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
is: HMDB01341
name: ADP(3-)
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN

metaM hs deg10 l
boundary condition: false
notes: FORMULA: C55H80N3O70S8 CHARGE: -9
is: HMDB00127
name: heparan sulfate, degradation product 10
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:15748
initial amount: NaN
constant: false
initial concentration: 1.0

metaR FUMtm
modifier: MODEL1310110023#
product: MODEL1310110023#
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV
is described by: ECO:0000269
name: fumarate transport, mitochondrial
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110023#
reversible: true

metaM nad r
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:57540
type: Species
initial amount: NaN
name: NAD(1-)
is: HMDB00902

metaM ksii core4 pre5 g
boundary condition: false
is: C00130
name: keratan sulfate II biosynthesis, precursor 5
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB00175
type: Species
notes: FORMULA: C69H112N6O48X CHARGE: -1
is: CHEBI:58053
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110023#_c219c48c_fa46_4c7f_bc5c_624a57201d5a
initial amount: NaN
is: Q13825
constant: false
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
name: AUH
is encoded by: hsa:549
initial concentration: NaN

metaR G14T10g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
product: MODEL1310110023#
reversible: false
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8703.1) or (8704.2) or (8704.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
fast: false
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110023#_f29d1735_70ef_401e_9f0e_7fc5923861aa
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: PIGP
is encoded by: hsa:51227
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: P57054

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

metaR S6T1g
reactant: MODEL1310110023#
reversible: false
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
modifier: MODEL1310110023#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
type: Reaction
product: MODEL1310110023#

metaM phytcoa x
boundary condition: false
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
name: phytanoyl-CoA(4-)
has only substance units: false
initial amount: NaN
is: HMDB01359
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57391
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_d02aef8d_fe5f_4c83_9fda_4b299993acd9
boundary condition: true
has only substance units: false
constant: false
is: B2R6S5
type: Species
is encoded by: hsa:51727
name: CMPK1
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaM ditp c
constant: false
type: Species
name: dITP(4-)
is: CHEBI:61382
is: HMDB03537
has only substance units: false
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaR EHGLATm
kinetic law: MODEL1310110023#
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase, mitochondrial
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.1
type: Reaction
is: SBO:0000176
reactant: MODEL1310110023#
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.1 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
reversible: false
product: MODEL1310110023#
modifier: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_f8aecea1_87c1_44d1_ab91_cab4bde07da6
name: CPOX
initial amount: NaN
has only substance units: false
is: P36551
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:1371
initial concentration: NaN
constant: false

metaM pe hs m
is: CHEBI:16038
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
initial concentration: 1.0
name: phosphatidylethanolamine

http://identifiers.org/biomodels.db/MODEL1310110023#_697cd86b_71cf_433b_b017_74252d98e0ca
is: Q92521
type: Species
constant: false
name: PIGB
is encoded by: hsa:9488
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaR EX xyl D LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Xylose exchange
type: Reaction

metaR GLNtN1
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110023#
name: Glutamine transport (Na, H coupled)
type: Reaction
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
reactant: MODEL1310110023#
product: MODEL1310110023#
fast: false
is: SBO:0000185
modifier: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_c5c19756_e8f9_4d53_a495_4a420f33c597
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:126
has only substance units: false
name: ADH1C
is: SBO:0000252
is: P00326
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110023#_5323c8d6_1095_49bf_a568_8b1dc3d40b72
initial concentration: NaN
boundary condition: true
is: Q16881
name: TXNRD1
is encoded by: hsa:7296
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
type: Species

metaR r2532
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110023#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reversible: true

metaR r0944
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
type: Reaction
kinetic law: MODEL1310110023#
fast: false
reactant: MODEL1310110023#
name: Active transport
product: MODEL1310110023#
is: SBO:0000185
reversible: true

metaR r0730
kinetic law: MODEL1310110023#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is: SBO:0000176
product: MODEL1310110023#
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
fast: false
modifier: MODEL1310110023#
reversible: false
reactant: MODEL1310110023#

metaM cholcoar r
is: SBO:0000247
boundary condition: false
is: HMDB02178
is: CHEBI:58677
initial amount: NaN
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
constant: false
type: Species
has only substance units: false
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110023#_cf0d0eae_1511_419b_b834_0d1d72143012
type: Species
initial amount: NaN
boundary condition: true
is: O75414
constant: false
initial concentration: NaN
is encoded by: hsa:10201
has only substance units: false
is: SBO:0000252
name: NME6

metaR GK1
product: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
reversible: true
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.8
modifier: MODEL1310110023#
reactant: MODEL1310110023#
name: guanylate kinase (GMP:ATP)
kinetic law: MODEL1310110023#

metaR RE0935E
is: SBO:0000176
reactant: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.2.1.1
modifier: MODEL1310110023#
reversible: true
name: RE0935
kinetic law: MODEL1310110023#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110023#_898b4ee6_8fbd_441f_a274_0421ec34310b
is: P27707
initial concentration: NaN
name: DCK
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:1633
type: Species
is: SBO:0000252
initial amount: NaN

metaR r0517
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.17.4.1
type: Reaction
product: MODEL1310110023#
reversible: true
is described by: ECO:0000000
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110023#_ed789662_897b_4255_9c74_436ccfe57051
name: GNS
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2799
type: Species
is: Q7Z3X3
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_d566c5ba_2bac_4858_9a4c_ee13687c1552
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:10637
is: O75610
type: Species
initial amount: NaN
name: LEFTY1
has only substance units: false
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110023#_84cbe4dd_fcc5_4d22_8dba_3b24c4d2643d
initial amount: NaN
boundary condition: true
name: SLC24A4
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:123041
constant: false
type: Species

metaR EHGLAT2m
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
is: SBO:0000176
product: MODEL1310110023#
reversible: false
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase 2, mitochondrial
type: Reaction
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.21 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:NCD SAB oaa -> asp-L
reactant: MODEL1310110023#
is described by: ECO:0000304
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.1

metaR H2O2tn
product: MODEL1310110023#
name: hydrogen peroxide nuclear transport
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:it
reactant: MODEL1310110023#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110023#

metaR RE1807C
reactant: MODEL1310110023#
product: MODEL1310110023#
is described by: ECO:0000000
type: Reaction
reversible: true
kinetic law: MODEL1310110023#
name: RE1807
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
is: SBO:0000176

metaR PHYHx
is version of: http://identifiers.org/ec-code/1.14.11.18
is: SBO:0000176
modifier: MODEL1310110023#
fast: false
type: Reaction
product: MODEL1310110023#
name: Phytanoyl-CoA dioxygenase, peroxisomal
reversible: false
notes: GENE_ASSOCIATION: (5264.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.14.11.18 Confidence Level: 4 AUTHORS: PMID:8954107,PMID:9326940 NOTES:NJ
reactant: MODEL1310110023#
is described by: ECO:0000269
kinetic law: MODEL1310110023#

metaR CO2ter
fast: false
name: CO2 endoplasmic reticular transport via diffusion
reactant: MODEL1310110023#
is: SBO:0000185
type: Reaction
reversible: true
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110023#
is described by: ECO:0000000

metaM pail4p hs c
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
is: CHEBI:58178
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110023#_620b2f8a_4a12_4dcc_ac1d_9f55a9c7a4b4
boundary condition: true
name: ND4
constant: false
has only substance units: false
initial concentration: NaN
is: P03905
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4538

metaM aps c
name: 5'-adenylyl sulfate(2-)
boundary condition: false
is: HMDB01003
initial concentration: 1.0
type: Species
notes: FORMULA: C10H12N5O10PS CHARGE: -2 INCHI: InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00204 EHMN_ABBREVIATION: C00224
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:58243
initial amount: NaN

metaR r0731
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
kinetic law: MODEL1310110023#
product: MODEL1310110023#
fast: false
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reversible: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110023#

metaM nad m
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/3305
is: SBO:0000247
is: CHEBI:57540
constant: false
initial amount: NaN
name: Nicotinamide adenine dinucleotide
type: Species
initial concentration: 1.0
is: HMDB00902
is: C00003

http://identifiers.org/biomodels.db/MODEL1310110023#_683c7226_8a6a_4b78_9619_78b42a16260e
has only substance units: false
initial amount: NaN
boundary condition: true
name: FLAD1
is encoded by: hsa:80308
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN

metaM tchola e
notes: FORMULA: C26H45NO7S CHARGE: 0
initial amount: NaN
is: HMDB00036
name: taurocholic acid
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species

metaM 4ppcys m
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: HMDB01117
is: CHEBI:59458
is: SBO:0000247
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110023#_8219aa22_70a7_4676_a731_a5fb42feaab9
has only substance units: false
is: P51160
boundary condition: true
type: Species
is encoded by: hsa:5146
name: PDE6C
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110023#_ab52a61f_be5f_4e61_91db_6a109c4ea7c1
is: P27144
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:205
constant: false
name: AK4
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_09ed3b3e_eddb_42a5_981f_375ddc20a76f
has only substance units: false
is: P04745
initial concentration: NaN
name: AMY1B
is encoded by: hsa:277
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
constant: false

metaR r2534
reactant: MODEL1310110023#
product: MODEL1310110023#
reversible: true
kinetic law: MODEL1310110023#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_6473abba_ad51_4ae3_9ab0_46e25d221bf7
is: SBO:0000252
type: Species
boundary condition: true
is: F5H066
constant: false
initial concentration: NaN
name: SLC12A4
initial amount: NaN
has only substance units: false
is encoded by: hsa:6560

metaR r0732
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110023#
product: MODEL1310110023#
fast: false
reactant: MODEL1310110023#
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reversible: false

metaR r0885
reactant: MODEL1310110023#
product: MODEL1310110023#
is described by: ECO:0000000
kinetic law: MODEL1310110023#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
modifier: MODEL1310110023#
is: SBO:0000185
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/1.3.1.38
type: Reaction
fast: false

metaR UMPK4n
reversible: true
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is described by: ECO:0000269
product: MODEL1310110023#
is: SBO:0000176
reactant: MODEL1310110023#
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (GTP),nuclear

metaR UDPDOLPT U
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.4.1.117
modifier: MODEL1310110023#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (uterus)
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:10359825,PMID:8280060 NOTES:NCD
fast: false
product: MODEL1310110023#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110023#_f6d65c62_b2c4_47ed_95bb_d65a0dc8d07a
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:6521
name: SLC4A1
initial amount: NaN
is: SBO:0000252
is: P02730
type: Species
boundary condition: true

metaM xylt c
name: xylitol
type: Species
initial concentration: 1.0
is: HMDB02917
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
boundary condition: false
is: CHEBI:17151
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaR FAS160COA
product: MODEL1310110023#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
reversible: false
modifier: MODEL1310110023#
is: SBO:0000176
name: fatty-acyl-CoA synthase (n-C16:0CoA)
kinetic law: MODEL1310110023#

metaR P5CR
reversible: false
kinetic law: MODEL1310110023#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 4 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:
type: Reaction
name: pyrroline-5-carboxylate reductase
reactant: MODEL1310110023#
fast: false
is described by: ECO:0000134
product: MODEL1310110023#

metaR IDPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction
reactant: MODEL1310110023#
is described by: ECO:0000000
kinetic law: MODEL1310110023#
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110023#
name: IDP nuclear transport

metaR r2535
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110023#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
product: MODEL1310110023#
type: Reaction
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110023#_e002e12d_4e85_4e13_a31c_f890d96c5911
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
name: TXNRD2
constant: false
is: Q9NNW7
is encoded by: hsa:10587
initial concentration: NaN
boundary condition: true

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

metaR H2O2tp
kinetic law: MODEL1310110023#
reversible: true
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
reactant: MODEL1310110023#
is described by: ECO:0000000
product: MODEL1310110023#
name: hydrogen peroxide peroxisomal transport via diffusion

metaR FAOXC183806m
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 3 degrees loss of saturation -> only 2 fad oxidized to fadh2 - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c18:3,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110023#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
reversible: false
kinetic law: MODEL1310110023#
name: Beta oxidation of fatty acid
fast: false
product: MODEL1310110023#
is: SBO:0000176

metaR r0733
is version of: http://identifiers.org/ec-code/1.5.1.12
reversible: false
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
product: MODEL1310110023#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110023#
is: SBO:0000176
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35

http://identifiers.org/biomodels.db/MODEL1310110023#_5942ce1d_70f9_418e_9bd3_0a64e169cb03
name: CLYBL
is: SBO:0000252
type: Species
is encoded by: hsa:171425
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is: Q8N0X4

metaM HC00591 c
boundary condition: false
constant: false
type: Species
is: CHEBI:16769
initial concentration: 1.0
name: 2-oxoglutaramate
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_5fa3120e_16a6_427f_8f7c_57e49de27f6a
boundary condition: true
type: Species
is: P48736
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:5294
is: SBO:0000252
name: PIK3CG
has only substance units: false

metaM lneldccrn c
is: HMDB06461
boundary condition: false
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: Linoelaidyl carnitine
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9+,13-12+

http://identifiers.org/biomodels.db/MODEL1310110023#_b41fe73d_a28f_44bc_b1db_796ec5a3e747
is: Q16836
constant: false
is encoded by: hsa:3033
is: SBO:0000252
name: HADH
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaM cl e
initial amount: NaN
name: Chloride
is: SBO:0000247
boundary condition: false
type: Species
is: C00115
constant: false
initial concentration: 1.0
is: CHEBI:3966
notes: FORMULA: Cl CHARGE: -1
has only substance units: false
is: HMDB00492

http://identifiers.org/biomodels.db/MODEL1310110023#_e95475ec_6095_4b32_a5bd_dd1788055d08
is: P14550
is encoded by: hsa:10327
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
constant: false
boundary condition: true
name: AKR1A1

http://identifiers.org/biomodels.db/MODEL1310110023#_96319749_743a_44db_952a_89af23329f16
is: SBO:0000252
is encoded by: hsa:30
is: Q96CA6
has only substance units: false
initial concentration: NaN
type: Species
name: ACAA1
constant: false
initial amount: NaN
boundary condition: true

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

metaR MERCPLACCYSt
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:excretion of 3-mercaptolactate-cysteine disulfide (PMID: 6945862) MM
type: Reaction
is: SBO:0000185
product: MODEL1310110023#
is described by: ECO:0000000
kinetic law: MODEL1310110023#
name: 3-mercaptolactate-cysteine disulfide transport, extracellular
fast: false
reversible: false

metaR r0407
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110023#
is: SBO:0000176
modifier: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
product: MODEL1310110023#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.5
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13

metaM retinol cis 11 c
type: Species
constant: false
boundary condition: false
is: CHEBI:16302
initial concentration: 1.0
initial amount: NaN
name: 11-cis-retinol
has only substance units: false
is: HMDB06216
is: SBO:0000247
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+

http://identifiers.org/biomodels.db/MODEL1310110023#_fbcbc433_c1fe_496d_94cc_a54068c0de71
initial concentration: NaN
is: O76082
is encoded by: hsa:6584
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
name: SLC22A5
has only substance units: false
type: Species

metaR F6Tg
modifier: MODEL1310110023#
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (2530.4) or (2530.1) or (2530.3) or (2530.2) or (2530.5) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.68 Confidence Level: 0 AUTHORS: PMID:14514715 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110023#
fast: false
reversible: false
reactant: MODEL1310110023#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.68
type: Reaction
name: glycoprotein 6-alpha-L-fucosyltransferase

metaR SERtN1
reactant: MODEL1310110023#
is: SBO:0000185
reversible: true
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
product: MODEL1310110023#
name: Serine transport (Na, H coupled)
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110023#
type: Reaction

metaM co2 x
constant: false
boundary condition: false
is: CHEBI:16526
initial concentration: 1.0
has only substance units: false
name: carbon dioxide
is: SBO:0000247
initial amount: NaN
notes: FORMULA: CO2 CHARGE: 0 INCHI: InChI=1S/CO2/c2-1-3 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: HMDB01967
type: Species

metaR FAOXC103C102m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)m
type: Reaction

metaR r0408
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.4.3.5
kinetic law: MODEL1310110023#
is described by: ECO:0000000
modifier: MODEL1310110023#
fast: false
is: SBO:0000176
reversible: true
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
type: Reaction
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
product: MODEL1310110023#

metaM xylt e
initial amount: NaN
name: xylitol
constant: false
has only substance units: false
is: HMDB02917
initial concentration: 1.0
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
is: CHEBI:17151
is: SBO:0000247
type: Species
boundary condition: false

metaR ALAGLYexR
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
type: Reaction
name: L-alanine/glycine reversible exchange
product: MODEL1310110023#
reactant: MODEL1310110023#
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
fast: false
is described by: ECO:0000304

metaM HC00591 m
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: 2-oxoglutaramate
initial concentration: 1.0
is: CHEBI:16769
constant: false
boundary condition: false
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
type: Species

metaM glu5sa m
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
is: HMDB02104
has only substance units: false
initial amount: NaN
name: L-Glutamate 5-semialdehyde
constant: false
is: CHEBI:17232
boundary condition: false
is: C01165

http://identifiers.org/biomodels.db/MODEL1310110023#_7ef9a3f9_9cb1_4bee_9683_52a6ab0e14b5
is: P54750
name: PDE1A
is encoded by: hsa:5136
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN

metaR RE1531M
product: MODEL1310110023#
reversible: true
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
type: Reaction
modifier: MODEL1310110023#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE1531
reactant: MODEL1310110023#

metaR G16MT U
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
name: Glycolipid 1,6-alpha-D-mannosyltransferase (uterus)
product: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
type: Reaction
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#

metaM prist c
constant: false
initial amount: NaN
is: SBO:0000247
name: pristanic acid
is: HMDB00795
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
boundary condition: false
is: CHEBI:51340

http://identifiers.org/biomodels.db/MODEL1310110023#_f11c9d97_38d9_4951_9275_6c33ce54f039
initial amount: NaN
is: Q13232
name: NME3
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:4832

http://identifiers.org/biomodels.db/MODEL1310110023#_0e9a1307_e311_4d3f_81b3_49702481e141
initial amount: NaN
boundary condition: true
is: Q92835
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:3635
has only substance units: false
name: INPP5D

metaM tchola c
name: taurocholic acid
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:36257
type: Species
is: HMDB00036
boundary condition: false

metaM pe hs e
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: phosphatidylethanolamine
constant: false
boundary condition: false
type: Species
is: CHEBI:16038
initial amount: NaN

metaR ASPGLUm
is: SBO:0000185
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (8604.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
reactant: MODEL1310110023#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110023#
type: Reaction
name: aspartate-glutamate mitochondrial shuttle
reversible: true
product: MODEL1310110023#

metaR FAOXC102m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:2)m
type: Reaction

metaR MTHFD2m
type: Reaction
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
fast: false
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.5.4.9
modifier: MODEL1310110023#
reversible: true
is described by: ECO:0000254

metaM dhcrm hs c
initial concentration: 1.0
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126
boundary condition: false
is: SBO:0000247
constant: false
name: dihydroceramide
is: CHEBI:31488
initial amount: NaN
has only substance units: false
type: Species

metaM ins c
name: Inosine
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
initial concentration: 1.0
has only substance units: false
is: CHEBI:17596
type: Species
is: HMDB00195
is: C00294
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false

metaM gpail hs c
is: SBO:0000247
has only substance units: false
is: CHEBI:17049
name: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
notes: FORMULA: C15H28NO13PFULLRCO2FULLR2CO2 CHARGE: 0 EHMN_ABBREVIATION: C04248
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
constant: false

metaM cholcoar x
type: Species
boundary condition: false
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
is: HMDB02178
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:58677
initial concentration: 1.0

metaR FOLR2
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
is: SBO:0000176
fast: false
modifier: MODEL1310110023#
reactant: MODEL1310110023#
type: Reaction
name: folate reductase
is described by: ECO:0000254
kinetic law: MODEL1310110023#
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.5.1.3

metaR DHCR72r
reversible: false
is: SBO:0000176
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
type: Reaction
fast: false
is described by: ECO:0000269
name: 7-dehydrocholesterol reductase
product: MODEL1310110023#
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.3.1.21

metaR CERT1gt
reversible: true
reactant: MODEL1310110023#
name: ceramide transport protein
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.11.1
modifier: MODEL1310110023#
is: SBO:0000185
is described by: ECO:0000304
kinetic law: MODEL1310110023#
fast: false
product: MODEL1310110023#

metaR DINt
reversible: true
type: Reaction
name: deoxyinosine transport via diffusion
fast: false
product: MODEL1310110023#
is described by: ECO:0000000
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is: SBO:0000185
reactant: MODEL1310110023#

metaR r0403
kinetic law: MODEL1310110023#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.4.4
is: SBO:0000176
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.4 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110023#
product: MODEL1310110023#
modifier: MODEL1310110023#
fast: false
type: Reaction
reversible: true
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) Tryptophan metabolism EC:1.14.16.4

metaR DNDPt25m
reversible: false
product: MODEL1310110023#
is: SBO:0000185
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
modifier: MODEL1310110023#
name: dTDP transport via dCDP antiport
type: Reaction

metaM adp c
type: Species
name: ADP
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: C00008
is: CHEBI:16761
is: HMDB01341
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/3310

metaR KYNATESYN
reactant: MODEL1310110023#
is: SBO:0000176
reversible: false
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES:SAB name is a guess
kinetic law: MODEL1310110023#
type: Reaction
name: 4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase
product: MODEL1310110023#

metaR NDP10ex
fast: false
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:IT
reactant: MODEL1310110023#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.6.1.6
product: MODEL1310110023#
is described by: ECO:0000269
name: nucleoside-diphosphatase (IDP), extracellular
reversible: false
modifier: MODEL1310110023#

metaR FAOXC11
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 2 AUTHORS: PMID:9819701 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211 1 round of beta ox of branched chain FA from peroxisome NJ
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110023#
kinetic law: MODEL1310110023#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
name: Beta oxidation of long chain fatty acid
fast: false
modifier: MODEL1310110023#
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_20846e44_18c4_4745_a2ce_c2fb1b6ee104
initial concentration: NaN
has only substance units: false
is: Q9BYG0
name: B3GNT5
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:84002
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_4b5ea03f_16b4_4521_bd6c_60af420536fb
has only substance units: false
is encoded by: hsa:4702
is: B1AM93
is: SBO:0000252
name: NDUFA8
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_982efef4_e0a5_4f47_9e4f_24de02d7c760
initial concentration: NaN
is: Q14032
initial amount: NaN
boundary condition: true
name: BAAT
is: SBO:0000252
constant: false
has only substance units: false
type: Species
is encoded by: hsa:570

metaR EX 3mop LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxopentanoate
type: Reaction

metaR MALTSULtm
is described by: ECO:0000269
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
type: Reaction
modifier: MODEL1310110023#
reversible: true
kinetic law: MODEL1310110023#
product: MODEL1310110023#
name: Malate:thiosulfate antiport, mitochondrial
reactant: MODEL1310110023#

metaM 3hexdtricoa m
constant: false
is: HMDB02288
initial amount: NaN
has only substance units: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
type: Species
boundary condition: false
initial concentration: 1.0
name: 3,7,10-hexadecatrienoylcoa
is: SBO:0000247

metaM pe hs c
initial amount: NaN
name: phosphatidylethanolamine
boundary condition: false
has only substance units: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
is: CHEBI:16038

metaR RE1807M
reversible: true
is version of: http://identifiers.org/ec-code/1.14.13.15
reactant: MODEL1310110023#
product: MODEL1310110023#
kinetic law: MODEL1310110023#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110023#
is described by: ECO:0000000
name: RE1807
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_d4b8c5ca_5c61_4d0e_8bf6_24c46f1b144f
constant: false
initial concentration: NaN
name: CSAD
initial amount: NaN
is encoded by: hsa:51380
type: Species
is: SBO:0000252
is: Q96JQ3
has only substance units: false
boundary condition: true

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

metaR EX cspg b LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan exchange
type: Reaction

metaM ctdecdcoa m
initial concentration: 1.0
name: cis2trans4decadienoylcoa
has only substance units: false
type: Species
constant: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial amount: NaN
is: SBO:0000247
is: HMDB12969
boundary condition: false

metaM cl c
constant: false
notes: FORMULA: Cl CHARGE: -1
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
name: Chloride
is: CHEBI:3966
is: HMDB00492
is: SBO:0000247
is: C00115

http://identifiers.org/biomodels.db/MODEL1310110023#_3f9c64f9_63ab_42ab_a4d8_c8e176eb58a0
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:4645
name: MYO5B
type: Species
is: SBO:0000252
is: Q9H6Y6
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_d439a5ad_7f9a_498c_a7e3_f7d3ce1b6f7e
boundary condition: true
type: Species
is encoded by: hsa:8525
is: B7Z2M9
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: DGKZ
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_9e2fda4f_889a_487d_aee8_2c683536e350
type: Species
has only substance units: false
is: P28330
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:33
constant: false
boundary condition: true
initial amount: NaN
name: ACADL

metaM 4ppcys c
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
has only substance units: false
is: SBO:0000247
is: HMDB01117
type: Species
constant: false
initial amount: NaN
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
is: CHEBI:59458
is: C04352

metaM ditp n
is: HMDB03537
initial amount: NaN
is: SBO:0000247
name: dITP(4-)
initial concentration: 1.0
is: CHEBI:61382
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
constant: false
has only substance units: false
boundary condition: false
type: Species

metaR DCSPTN1CPT2
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
type: Reaction
reactant: MODEL1310110023#
reversible: false
fast: false
modifier: MODEL1310110023#
name: carnitine transferase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110023#

metaR PSFLIPm
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ
modifier: MODEL1310110023#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.3.1
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
reversible: false
is: SBO:0000185
product: MODEL1310110023#
is described by: ECO:0000269
fast: false
name: phosphatidylserine flippase

http://identifiers.org/biomodels.db/MODEL1310110023#_fcd5b4e8_ee17_4466_979a_a86cf6ebfbed
constant: false
name: NDUFB2
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: H7C5B8
is encoded by: hsa:4708
initial concentration: NaN
type: Species
has only substance units: false

metaM dlnlcgcoa r
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
is: C03595
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: dihomo-gamma-linolenyl coenzyme A
is: CHEBI:27979
constant: false
boundary condition: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110023#_4dc0b57d_8083_4864_9b61_9973a717ff3a
initial amount: NaN
name: PDE9A
constant: false
type: Species
boundary condition: true
is encoded by: hsa:5152
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaM hdcea r
boundary condition: false
has only substance units: false
type: Species
name: palmitoleate
initial amount: NaN
constant: false
is: CHEBI:32372
is: HMDB03229
is: SBO:0000247
notes: FORMULA: C16H29O2 CHARGE: -1 INCHI: InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7- HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
initial concentration: 1.0

metaR DOLGLCP Uter
is described by: ECO:0000000
kinetic law: MODEL1310110023#
name: Dolichyl beta-D-glucosyl phosphate flippase (uterus)
type: Reaction
fast: false
product: MODEL1310110023#
is: SBO:0000185
reversible: false
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110023#_4a9c4a83_0a13_489b_a62d_530eb6a26c2b
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:8854
initial concentration: NaN
constant: false
is: O94788
boundary condition: true
has only substance units: false
name: ALDH1A2

metaR G14T3g
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
product: MODEL1310110023#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
reversible: false
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.4.1.90
reactant: MODEL1310110023#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110023#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

http://identifiers.org/biomodels.db/MODEL1310110023#_d17973d9_77c6_44fa_a6b7_d7f4ac242f1f
constant: false
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:1650
is: P39656
name: DDOST
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR APOCF
name: Apocarboxylase formation
reversible: false
product: MODEL1310110023#
is described by: ECO:0000000
reactant: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10191093 NOTES:IT faked reaction to balance reaction in human biotin metabolism
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110023#

metaR FAOXC101C102x
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)x
type: Reaction

metaR DCSPTN1CPT1
is described by: ECO:0000269
kinetic law: MODEL1310110023#
reversible: false
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine O-palmitoyltransferase
modifier: MODEL1310110023#
product: MODEL1310110023#
fast: false
type: Reaction
is: SBO:0000176

metaR FAOXC140
product: MODEL1310110023#
fast: false
is described by: ECO:0000269
is: SBO:0000176
name: Beta oxidation of long chain fatty acid
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
reversible: false

metaM imp c
type: Species
initial concentration: 1.0
is: HMDB00175
name: IMP
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:58053
is: C00130
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_ac1510ed_d5fd_4f6d_8098_ea6b2fffa22a
initial concentration: NaN
is encoded by: hsa:2235
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: FECH
boundary condition: true
type: Species
is: Q7KZA3
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_cf740d74_1053_48ef_819c_7b607dfa7522
is encoded by: hsa:4717
type: Species
has only substance units: false
name: NDUFC1
constant: false
is: O43677
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaM hco3 c
name: Bicarbonate
has only substance units: false
is: HMDB00595
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: C00288
initial amount: NaN
is: CHEBI:17544
constant: false

metaM hx2coa m
has only substance units: false
type: Species
initial concentration: 1.0
name: trans-Hex-2-enoyl-CoA
constant: false
boundary condition: false
initial amount: NaN
is: HMDB13037
is: SBO:0000247
is: C00888
notes: FORMULA: C27H40N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110023#_7f9eb834_d8ed_48ac_b0a4_05d03c692e04
initial amount: NaN
name: GPT
type: Species
is: P24298
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:2875

http://identifiers.org/biomodels.db/MODEL1310110023#_74d713dc_5c10_40ef_9560_d148d8f8cb9d
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:10005
name: ACOT8
constant: false
type: Species
is: SBO:0000252
boundary condition: true
is: O14734

http://identifiers.org/biomodels.db/MODEL1310110023#_18869f84_206d_407b_805a_2a5eaf0d0c29
name: DGUOK
is: E5KSL6
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1716
initial amount: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_a49fa013_5581_40b8_a98c_431dd7f8b661
is: O95861
initial concentration: NaN
name: BPNT1
has only substance units: false
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:10380
boundary condition: true
initial amount: NaN

metaR EX tsul LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiosulfate exchange
type: Reaction

metaM g1p c
initial amount: NaN
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
type: Species
boundary condition: false
name: D-Glucose 1-phosphate
is: C00103
is: SBO:0000247
constant: false
is: HMDB01586
initial concentration: 1.0
is: CHEBI:58601
has only substance units: false

metaM r5p r
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-3-2(1-12-14(9,10)11)13-5(8)4(3)7/h2-8H,1H2,(H2,9,10,11)/t2-,3-,4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
has only substance units: false
is: SBO:0000247
is: CHEBI:18189
type: Species
boundary condition: false
name: alpha-D-Ribose 5-phosphate
is: HMDB00618

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_987fad2b_27da_4684_8d4f_14a92a11859d
constant: false
initial amount: NaN
type: Species
name: SLC2A11
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:66035
is: Q8WXF9
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110023#_12bd23de_3b24_4f21_b4ed_98fb66a9ecad
initial concentration: NaN
is encoded by: hsa:5143
has only substance units: false
is: SBO:0000252
is: Q7KYS4
initial amount: NaN
boundary condition: true
name: PDE4C
constant: false
type: Species

metaR L LACDcm
reactant: MODEL1310110023#
reversible: false
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (124637.1) SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:18831974 NOTES:NCD/TDV. This reaction exists in yeast, but no evidence could be found this exists in humans. However, there may be intramitochondrial lactate dehydrogenase and lactate transport into mitochondria
kinetic law: MODEL1310110023#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110023#
is: SBO:0000185
fast: false
name: L-Lactate dehydrogenase, cytosolic/mitochondrial

metaR FAOXC102C101m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: reduction(C10:2-->C10:1)m
type: Reaction

metaM thmmp c
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C12H16N4O4PS CHARGE: -1 EHMN_ABBREVIATION: C01081
boundary condition: false
is: C01081
constant: false
name: Thiamin monophosphate
is: HMDB02666
has only substance units: false
is: CHEBI:37575

metaR FAOXC2251836m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
name: Beta oxidation of fatty acid
reactant: MODEL1310110023#
reversible: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_2 rounds of beta-ox, plus a loss of 2 degrees of desatuartion, so no fad is oxidized peroxisomal (very long chain FA) c22:5,n-6 -> c18:3, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_c14e16e2_6d65_47f1_82bf_5390b045bbe3
constant: false
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: PANK4
is encoded by: hsa:55229
is: Q9NVE7

http://identifiers.org/biomodels.db/MODEL1310110023#_f4edee0e_7302_459c_ac35_3e6ad399ecca
initial amount: NaN
is encoded by: hsa:AI640625
initial concentration: NaN
name: _AI640625_1_c
type: Species
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true

metaM CE5121 m
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:57449
name: trans-3-decenoyl-CoA
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
type: Species

metaR r1017
fast: false
name: Vesicular transport
reversible: false
kinetic law: MODEL1310110023#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12663868,PMID:14716480,PMID:15209530,PMID:15297262,PMID:1599411,PMID:17416343,PMID:9068608 NOTES:
reactant: MODEL1310110023#
is described by: ECO:0000000
product: MODEL1310110023#
type: Reaction

metaR FUCASEly
fast: false
reversible: false
is described by: ECO:0000000
is: SBO:0000176
name: alpha-fucosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.51
kinetic law: MODEL1310110023#
type: Reaction
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (2517.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.51 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110023#
product: MODEL1310110023#

metaM hco3 e
is: HMDB00595
name: Bicarbonate
has only substance units: false
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
is: C00288
initial amount: NaN
constant: false
is: CHEBI:17544

http://identifiers.org/biomodels.db/MODEL1310110023#_a4b46c89_d31a_49a3_b944_71851a9dc33d
initial amount: NaN
is: P37268
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:2222
boundary condition: true
name: FDFT1
type: Species
initial concentration: NaN

metaM 3ddecdicoa m
name: 3,6-dodecadienoylcoa
constant: false
is: SBO:0000247
type: Species
is: HMDB03952
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
is: C05280
notes: FORMULA: C33H50N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110023#_6a509620_e399_4510_9c9e_1d363b9c74a7
name: IDH1
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: O75874
initial concentration: NaN
is encoded by: hsa:3417
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110023#_e1a350c7_acbc_4026_81ab_8c1dec106aeb
type: Species
name: SLC4A9
is: SBO:0000252
constant: false
initial amount: NaN
is: E9PDK1
is encoded by: hsa:83697
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR DOLMANP Uter
is described by: ECO:0000000
fast: false
reversible: false
type: Reaction
name: dolichol-phosphate mannose flippase (uterus)
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
is: SBO:0000185

metaM co2 r
type: Species
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
initial amount: NaN
initial concentration: 1.0
name: CO2
is: CHEBI:16526
is: HMDB01967
is: C00011
has only substance units: false

metaR MEOHt2
reversible: true
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
fast: false
reactant: MODEL1310110023#
name: Methanol diffusion
product: MODEL1310110023#
kinetic law: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_9018465e_1678_42ba_8ca1_8f3345f7c16e
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:27235
has only substance units: false
is: Q96H96
type: Species
is: SBO:0000252
name: COQ2
initial concentration: NaN

metaR G14T20g
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110023#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
fast: false
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
kinetic law: MODEL1310110023#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
modifier: MODEL1310110023#

metaR r1018
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
product: MODEL1310110023#
name: Transport reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_74a53f07_38e2_424c_8770_bb83b783700f
type: Species
has only substance units: false
is encoded by: hsa:AI924226
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: _AI924226_1_m
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_9ebd0c20_933e_48e8_b0fc_503cd36e7e05
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
name: _AV713053_1_m
is encoded by: hsa:AV713053
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_927b8eb6_f5cc_4ad9_886a_f65a2f9360c2
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:6528
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q92911
name: SLC5A5
type: Species

metaM pail4p hs n
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
is: CHEBI:58178
boundary condition: false
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
type: Species
initial amount: NaN

metaR EX prostgi2 LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin I2(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_6935fe4d_0e7e_454e_a344_3e8b83cbdeae
name: CYP1B1
constant: false
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:1545
is: SBO:0000252
initial concentration: NaN
is: Q16678
boundary condition: true

metaM crm hs r
name: N-acylsphingosine
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:52639
is: SBO:0000247
boundary condition: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_64fac764_5d1a_4b92_9f8d_4597094b6216
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
is: Q99643
is encoded by: hsa:6391
type: Species
boundary condition: true
name: SDHC
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_9f3b0a79_2463_414e_b762_3b45698d97b8
type: Species
is: A8K0T6
initial concentration: NaN
name: SMPD3
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:55512
is: SBO:0000252

metaR DOLPGT1 Uer
reversible: false
type: Reaction
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (29929.1) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10359825 NOTES:EC 2.4.1.- NCD
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.4.1.267
product: MODEL1310110023#
fast: false
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#

metaR ASNSERNaEx
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
is: SBO:0000185
modifier: MODEL1310110023#
name: L-serine/L-asparagine Na-dependent exchange (Asn-L in)
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110023#

metaM ctp c
name: CTP
is: SBO:0000247
is: CHEBI:37563
initial concentration: 1.0
type: Species
has only substance units: false
is: C00063
initial amount: NaN
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
constant: false
boundary condition: false
is: HMDB00082

metaR r1019
product: MODEL1310110023#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110023#
name: Postulated transport reaction
reversible: true
reactant: MODEL1310110023#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:

metaR EX leuktrA4 LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene A4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_e3347ee3_4991_45cb_bffe_8787439aaf4e
has only substance units: false
is: Q9BV79
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:51102
name: MECR
initial amount: NaN
constant: false
type: Species
boundary condition: true

metaM maltpt e
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/5141
name: maltopentaose
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
is: C02052
type: Species
is: HMDB01296
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_da326c80_d1d7_423f_97a7_547e71886bb5
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
name: CROT
constant: false
is encoded by: hsa:54677
is: E7EQF2
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_df6500ee_6e85_4cd1_b1de_4669dfb0ea27
has only substance units: false
initial concentration: NaN
type: Species
name: PEMT
is encoded by: hsa:10400
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
is: Q9UBM1

http://identifiers.org/biomodels.db/MODEL1310110023#_509cca49_0fc0_428d_ae9a_fae66bdd4b72
boundary condition: true
has only substance units: false
is encoded by: hsa:377677
initial amount: NaN
constant: false
is: Q8N1Q1
type: Species
name: CA13
is: SBO:0000252
initial concentration: NaN

metaM amp m
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: AMP(2-)
is: HMDB00045
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:456215

metaR r1921
kinetic law: MODEL1310110023#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110023#
reactant: MODEL1310110023#
reversible: false
product: MODEL1310110023#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
is: SBO:0000185

metaR 3MOBte
kinetic law: MODEL1310110023#
reversible: true
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110023#
type: Reaction
fast: false
reactant: MODEL1310110023#
name: Transport of 3-methyl-2-oxobutanoate
is: SBO:0000185

metaR EX aicar LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
type: Reaction

metaR PPBNGS
is version of: http://identifiers.org/ec-code/4.2.1.24
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
is described by: ECO:0000269
name: porphobilinogen synthase
product: MODEL1310110023#
type: Reaction
fast: false
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (210.1) or (210.2) SUBSYSTEM: Heme synthesis EC Number: 4.2.1.24 Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
reversible: false

metaR CYTK14n
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110023#
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110023#
type: Reaction
reversible: true
fast: false
name: cytidylate kinase (dCMP,CTP),nuclear
product: MODEL1310110023#

metaM dhcholestanate m
type: Species
is: CHEBI:16577
boundary condition: false
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
is: SBO:0000247
constant: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
initial amount: NaN
has only substance units: false
is: HMDB00359
initial concentration: 1.0

metaM HC01444 e
is: CHEBI:15754
has only substance units: false
constant: false
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
name: Galactosylglycerol
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0

metaR GALASE10ly
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110023#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
type: Reaction

metaM CE5117 m
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117
is: CHEBI:57923
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA
initial concentration: 1.0
type: Species
has only substance units: false

metaM ctp e
is: CHEBI:37563
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
name: CTP(4-)
has only substance units: false
boundary condition: false
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: HMDB00082
is: SBO:0000247

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

metaR H2ETer
reactant: MODEL1310110023#
reversible: false
product: MODEL1310110023#
modifier: MODEL1310110023#
name: H2 phosphoethanolaminyl transferase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (23556.1) or (23556.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10574991 NOTES:NCD
kinetic law: MODEL1310110023#
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000304

metaM imp e
has only substance units: false
boundary condition: false
is: HMDB00175
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:58053
name: IMP(2-)
notes: FORMULA: C10H11N4O8P CHARGE: -2 INCHI: InChI=1S/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_0199e7e3_c5ad_4d07_8ff6_63a08cdcc700
initial concentration: NaN
constant: false
name: _AI697028_1_m
is encoded by: hsa:AI697028
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_b59bbc90_ccd1_4def_89c7_afd2f205e0a6
is: SBO:0000252
is encoded by: hsa:10331
is: Q9Y2A9
initial concentration: NaN
name: B3GNT3
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
type: Species

metaM 3hbcoa m
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
constant: false
type: Species
is: HMDB01166
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57316
has only substance units: false
boundary condition: false
name: (S)-3-hydroxybutanoyl-CoA(4-)

metaR MMCDm
type: Reaction
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (23417.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.1.1.9 Confidence Level: 1 AUTHORS: PMID:12123667,PMID:12955715 NOTES:JLR mitochondrial isoform - NCD
is described by: ECO:0000212
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.9
reactant: MODEL1310110023#
name: Methylmalonyl-CoA decarboxylase, mitochondrial
product: MODEL1310110023#
modifier: MODEL1310110023#
is: SBO:0000176

metaR LEUKTRA4t
reversible: true
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:
name: leukotriene A4 transport
is described by: ECO:0000269
product: MODEL1310110023#
type: Reaction
fast: false
reactant: MODEL1310110023#
is: SBO:0000185

metaR SERALANaEx
modifier: MODEL1310110023#
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110023#
reversible: false
reactant: MODEL1310110023#
type: Reaction
name: L-alanine/L-serine Na-dependent exchange (Ser-L in)
fast: false
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaR DDPGAm
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.2.14 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:14193832,PMID:15849464,PMID:9783918 NOTES:IT rxn is done by 4.1.2.14 and 4.1.3.16 mitochondrial isozyme - NCD
name: 2-dehydro-3-deoxy-phosphogluconate aldolase, mitochondrial
product: MODEL1310110023#
reversible: true
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176

metaR RE3628M
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110023#
name: RE3628
reversible: true
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/5.3.3.8
is described by: ECO:0000000
reactant: MODEL1310110023#

metaR ADK1m
reactant: MODEL1310110023#
reversible: true
fast: false
product: MODEL1310110023#
is described by: ECO:0000269
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (205.3) or (205.1) or (204.1) or (204.3) or (204.2) or (205.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:11485571,PMID:195572,PMID:8843353,PMID:9434148 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110023#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.3
name: adenylate kinase, mitochondrial

metaR BAMPPALDOX
is version of: http://identifiers.org/ec-code/1.2.1.3
is version of: http://identifiers.org/ec-code/1.2.1.36
notes: GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.36 Confidence Level: 1 AUTHORS: PMID:12586697 NOTES:SAB
modifier: MODEL1310110023#
is described by: ECO:0000212
name: beta-Aminopropion aldehyde:NAD+ oxidoreductase
fast: false
reactant: MODEL1310110023#
reversible: false
product: MODEL1310110023#
is: SBO:0000176
kinetic law: MODEL1310110023#
type: Reaction

metaR EX oagd3 hs LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 9-O-Acetylated GD3 (homo sapiens) exchange
type: Reaction

metaR r1167
reactant: MODEL1310110023#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110023#
is: SBO:0000176
reversible: false
product: MODEL1310110023#
name: EC:2.3.1.26
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:

metaM gal l
is: CHEBI:12936
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124
is: HMDB00143
name: D-galactose
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false

metaR DURIK1
is version of: http://identifiers.org/ec-code/2.7.1.21
modifier: MODEL1310110023#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (7083.1) or (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 2 AUTHORS: PMID:12535661,PMID:9342341 NOTES:
kinetic law: MODEL1310110023#
fast: false
is described by: ECO:0000254
is: SBO:0000176
name: deoxyuridine kinase (ATP:Deoxyuridine)
reactant: MODEL1310110023#
product: MODEL1310110023#

metaM hspg l
initial amount: NaN
is: HMDB01993
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
is: CHEBI:17899
is: SBO:0000247
name: heparan sulfate proteoglycan
constant: false

metaM pail35p hs c
initial concentration: 1.0
is: CHEBI:57923
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
boundary condition: false
is: SBO:0000247
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
initial amount: NaN
has only substance units: false
type: Species
constant: false

metaM hspg e
initial amount: NaN
type: Species
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
is: SBO:0000247
boundary condition: false
name: heparan sulfate proteoglycan
has only substance units: false
is: CHEBI:32366
constant: false
initial concentration: 1.0
is: HMDB02259

http://identifiers.org/biomodels.db/MODEL1310110023#_b899b9fa_7330_4c1e_ac72_a63a6943dca9
initial concentration: NaN
name: ALDH1L1
type: Species
constant: false
boundary condition: true
is encoded by: hsa:10840
is: O75891
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR CRNtx
product: MODEL1310110023#
name: carnitine transport peroxisome to mitochondria
type: Reaction
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12814641,PMID:15464416 NOTES:mechanism not currently elucidated NJ

metaR BAAT4x
reversible: false
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 2 AUTHORS: NOTES:fourth version analog added in similarity to BAAT1x, BAAT2x NJ
is version of: http://identifiers.org/ec-code/2.3.1.65
is described by: ECO:0000304
reactant: MODEL1310110023#
is: SBO:0000176
name: bile acid Coenzyme A: amino acid N-acyltransferase
type: Reaction
product: MODEL1310110023#
fast: false

metaM 3ddecdicoa x
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
is: C05280
name: 3,6-dodecadienoylcoa
is: HMDB03952
boundary condition: false
type: Species

metaR r0509
reactant: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: 1.3.5.1 Confidence Level: 0 AUTHORS: PMID:2843227 NOTES:
fast: false
reversible: false
kinetic law: MODEL1310110023#
is described by: ECO:0000000
product: MODEL1310110023#
is: SBO:0000176
name: Succinate:ubiquinone oxidoreductase Citrate cycle (TCA cycle) EC:1.3.5.1

metaR r2537
product: MODEL1310110023#
kinetic law: MODEL1310110023#
fast: false
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110023#
type: Reaction
name: Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true

metaR FACOAL2042
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110023#
type: Reaction
modifier: MODEL1310110023#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA alternate to arachidonic acid (n-3 rather than n-6) NJ
reversible: true
reactant: MODEL1310110023#
is described by: ECO:0000000
product: MODEL1310110023#

metaR NAHCO3 HCLt
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
product: MODEL1310110023#
type: Reaction
name: bicarbonate transport (HCl/NaHCO3 exchange)
reactant: MODEL1310110023#
reversible: true
fast: false
is described by: ECO:0000269

metaR ACHEe
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.1.1.7
fast: false
is described by: ECO:0000269
reactant: MODEL1310110023#
reversible: false
type: Reaction
is: SBO:0000176
name: Acetylcholinesterase
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES:NJ
product: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_63f1d059_52c5_4bf8_a144_076aeaa20c37
is: Q9UJ70
initial amount: NaN
has only substance units: false
name: NAGK
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:55577
is: SBO:0000252
constant: false

metaM xol7a r
is: HMDB01496
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:1296
type: Species
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C03594
initial concentration: 1.0
name: 20-hydroxycholesterol

metaM cmp g
constant: false
boundary condition: false
has only substance units: false
is: HMDB00095
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: SBO:0000247
is: CHEBI:60377
initial amount: NaN
type: Species
initial concentration: 1.0
name: CMP(2-)

metaM CE5132 c
is: CHEBI:57923
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
type: Species
boundary condition: false
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_e6580dd6_712e_4beb_86a6_742b21bba90b
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
name: TXNRD1
is encoded by: hsa:7296
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_833753d6_6cb1_440d_906c_27cf8d0c51fb
initial amount: NaN
type: Species
is: P42336
is encoded by: hsa:5290
constant: false
name: PIK3CA
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_5598a3e8_7f11_4ba5_847e_771fc481566e
boundary condition: true
is: Q9NYQ3
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
type: Species
name: HAO2
is encoded by: hsa:51179
initial concentration: NaN

metaM nad x
initial concentration: 1.0
type: Species
is: C00003
is: SBO:0000247
is: CHEBI:57540
is: http://identifiers.org/pubchem.compound/3305
has only substance units: false
initial amount: NaN
is: HMDB00902
boundary condition: false
name: Nicotinamide adenine dinucleotide
constant: false

metaM 44mzym r
has only substance units: false
is: SBO:0000247
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
constant: false
is: HMDB01286
type: Species
initial concentration: 1.0
is: CHEBI:18364
name: 14-demethyllanosterol
initial amount: NaN
boundary condition: false

metaR CHATn
type: Reaction
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
name: Choline O-acetyltransferase
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110023#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.6
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#

metaM ksi g
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB01644
constant: false
has only substance units: false
name: keratan sulfate I
type: Species
initial concentration: 1.0
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
is: CHEBI:17140

http://identifiers.org/biomodels.db/MODEL1310110023#_4a712be5_0f21_473f_bb24_527f46f3c30d
is: O15357
boundary condition: true
constant: false
is encoded by: hsa:3636
initial amount: NaN
has only substance units: false
name: INPPL1
initial concentration: NaN
type: Species
is: SBO:0000252

metaR r1291
fast: false
product: MODEL1310110023#
name: Postulated transport reaction
reversible: true
reactant: MODEL1310110023#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110023#
type: Reaction

metaM amp c
boundary condition: false
name: AMP
is: C00020
is: CHEBI:3322
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O7P CHARGE: -2
constant: false
is: HMDB00045
type: Species
is: SBO:0000247
initial amount: NaN

metaM mercplaccys c
type: Species
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
is: HMDB06512
name: 3-mercaptolactate-cysteine disulfide
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaM gam6p c
is: CHEBI:12962
is: SBO:0000247
notes: FORMULA: C6H13NO8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00298 EHMN_ABBREVIATION: C00352
constant: false
has only substance units: false
name: D-Glucosamine 6-phosphate
initial amount: NaN
boundary condition: false
type: Species
is: HMDB01254
initial concentration: 1.0

metaM fpram c
notes: FORMULA: C8H15N3O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01329 EHMN_ABBREVIATION: C04640
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
is: C04640
boundary condition: false
constant: false
is: CHEBI:58478
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB06211
type: Species
initial concentration: 1.0

metaR LEUTAm
reversible: true
reactant: MODEL1310110023#
modifier: MODEL1310110023#
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110023#
name: leucine transaminase, mitochondrial
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.6.1.42

metaR r1809
name: Y+LAT2 Utilized transport
product: MODEL1310110023#
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110023#
modifier: MODEL1310110023#
type: Reaction
reversible: false

metaM c226crn c
boundary condition: false
name: cervonyl carnitine
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/127055
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB06510
has only substance units: false

metaR NACHEXA14ly
modifier: MODEL1310110023#
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
name: beta-N-acetylhexosaminidase A, lysosomal
reversible: false
product: MODEL1310110023#
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000000

metaR FAOXC18280m
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000000
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c18:2, transe -> c8:0 - 5 rounds of beta ox, lose 2 degrees of unsat - only 3 fad oxidized 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
name: Beta oxidation of fatty acid
is: SBO:0000176
fast: false
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110023#
type: Reaction
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_1732ba02_33ee_4cbc_a781_424dfa69deda
is: Q9Y2C5
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:10050
initial concentration: NaN
type: Species
name: SLC17A4
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_b774726f_cf5e_4d91_9568_d8e3b1f8515a
is encoded by: hsa:6390
name: SDHB
is: P21912
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN

metaR r1292
product: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reactant: MODEL1310110023#
is: SBO:0000185
name: Postulated transport reaction
fast: false
kinetic law: MODEL1310110023#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110023#_8d847c30_01ff_4b95_adad_af9ac5d00d78
boundary condition: true
is: B4E3E9
name: OGDH
is encoded by: hsa:4967
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
constant: false

metaM hmbil c
initial amount: NaN
boundary condition: false
is: HMDB01137
is: SBO:0000247
type: Species
is: C01024
is: CHEBI:57845
initial concentration: 1.0
notes: FORMULA: C40H38N4O17 CHARGE: -8 HEPATONET_1.0_ABBREVIATION: HC00628 EHMN_ABBREVIATION: C01024
name: Hydroxymethylbilane
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_190be722_bf51_44ee_ae3d_a3dbd17bcca0
type: Species
initial concentration: NaN
is encoded by: hsa:8659
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
name: ALDH4A1

http://identifiers.org/biomodels.db/MODEL1310110023#_691e3cc9_acf6_4b02_baec_48543f8f21ca
initial concentration: NaN
is encoded by: hsa:8526
constant: false
has only substance units: false
is: A1L4Q0
boundary condition: true
type: Species
name: DGKE
initial amount: NaN
is: SBO:0000252

metaM 3hexdtricoa x
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
constant: false
name: 3,7,10-hexadecatrienoylcoa
initial concentration: 1.0
initial amount: NaN
is: HMDB02288

http://identifiers.org/biomodels.db/MODEL1310110023#_f56b523d_dcd6_44e9_beda_e3c13f3017c6
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:4729
is: P19404
constant: false
name: NDUFV2
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110023#_5e655da9_708b_44a1_9444_54ba72d9b1ae
is encoded by: hsa:8802
name: SUCLG1
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
constant: false
is: P53597

metaM cs b l
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
boundary condition: false
has only substance units: false
is: CHEBI:36005
is: SBO:0000247
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), free chain
type: Species
is: HMDB02183

metaR r1010
fast: false
is described by: ECO:0000000
name: Postulated transport reaction
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is: SBO:0000185
product: MODEL1310110023#
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110023#_e2a81d3b_5986_46e3_8456_60b092cade21
is: SBO:0000252
name: NDUFA5
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: Q16718
is encoded by: hsa:4698
type: Species
constant: false

metaM dhcholestanate x
initial amount: NaN
constant: false
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
is: SBO:0000247
is: CHEBI:16577
type: Species
boundary condition: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
has only substance units: false
initial concentration: 1.0
is: HMDB00359

http://identifiers.org/biomodels.db/MODEL1310110023#_73266272_f095_4383_86f0_c34a19810403
initial amount: NaN
has only substance units: false
is: P42765
boundary condition: true
name: ACAA2
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:10449

metaR SIAASEly
is version of: http://identifiers.org/ec-code/3.2.1.23
name: sialidase, lysosomal
is described by: ECO:0000000
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
kinetic law: MODEL1310110023#
is: SBO:0000176
type: Reaction

metaR r2538
product: MODEL1310110023#
fast: false
is described by: ECO:0000000
name: Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

metaM lpam m
is: HMDB00962
is: SBO:0000247
type: Species
constant: false
name: lipoamide
boundary condition: false
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
initial amount: NaN
is: CHEBI:17460
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_9a6dd476_59f7_4f5d_9b79_3d2932940fbc
is: Q7GXZ1
initial concentration: NaN
is: SBO:0000252
name: ND6
is encoded by: hsa:4541
initial amount: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_c690032e_083f_42d9_a23d_8d0c373aaea7
type: Species
is encoded by: hsa:2982
is: D6RDW3
name: GUCY1A3
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false

metaM ksi pre18 g
is: HMDB00175
type: Species
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C163H262N11O132S5X CHARGE: -6
is: C00130
is: SBO:0000247
has only substance units: false
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 18

http://identifiers.org/biomodels.db/MODEL1310110023#_91c0d41e_5300_4dec_b1bd_f51180a6c98c
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110023#_3a995d26_8100_44b4_b8ba_be8c932a76b5
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:5092
is: SBO:0000252
is: P61457
has only substance units: false
initial amount: NaN
name: PCBD1

http://identifiers.org/biomodels.db/MODEL1310110023#_eaaa3796_9d60_4a21_ae1f_5d53ffd69b39
name: GUCY1A2
constant: false
is encoded by: hsa:2977
initial amount: NaN
has only substance units: false
is: P33402
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_163621e9_a61a_400e_b40b_b198befdac9d
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
name: _AI378339_1_m
is: SBO:0000252
type: Species
is encoded by: hsa:AI378339

http://identifiers.org/biomodels.db/MODEL1310110023#_6b7ef2b6_d2d6_4085_9695_c109ebb5b9b6
is encoded by: hsa:80864
name: EGFL8
type: Species
boundary condition: true
is: Q99944
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaR RE0453N
type: Reaction
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
product: MODEL1310110023#
modifier: MODEL1310110023#
reversible: true
is: SBO:0000176
reactant: MODEL1310110023#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.4.6
name: RE0453
fast: false

metaM amp e
is: C00020
name: AMP
boundary condition: false
type: Species
constant: false
is: HMDB00045
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
initial amount: NaN
has only substance units: false
is: CHEBI:456215
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110023#_31d817da_b576_4b92_a9c8_8e0f756f357f
is: O75746
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:8604
constant: false
is: SBO:0000252
name: SLC25A12

metaR RE2426C
type: Reaction
reversible: true
kinetic law: MODEL1310110023#
is described by: ECO:0000000
name: RE2426
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12044950 NOTES:
reactant: MODEL1310110023#
is: SBO:0000176
product: MODEL1310110023#

metaM gal e
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0
is: CHEBI:0
boundary condition: false
has only substance units: false
name: D-Galactose
is: C00124
is: HMDB00143
type: Species

metaR FAOXC16180m
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation fatty acid
kinetic law: MODEL1310110023#
is described by: ECO:0000269
reactant: MODEL1310110023#
fast: false
is: SBO:0000176

metaR ADCim
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 4.1.1.4 Confidence Level: 2 AUTHORS: NOTES:TDV (Voet & Voet pg 581) Non-enzymatic decarboxylation; spontaneous reaction added "m" suffix - NCD
fast: false
reactant: MODEL1310110023#
reversible: false
name: Acetoacetate decarboxylation (irreversible), mitochondrial
is: SBO:0000176
product: MODEL1310110023#
type: Reaction
kinetic law: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_22c96f36_f976_4663_9f8e_b75748c945db
constant: false
name: PANK2
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:80025
initial amount: NaN

metaR r0726
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.1.33
kinetic law: MODEL1310110023#
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
reversible: true
modifier: MODEL1310110023#
fast: false
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
type: Reaction
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110023#_ea0e2f3e_bdc0_43c3_98b9_e0ac15de93f4
is: SBO:0000252
name: GPX1
boundary condition: true
type: Species
is encoded by: hsa:2876
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN

metaM pe hs r
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
name: phosphatidylethanolamine
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
is: CHEBI:16038

http://identifiers.org/biomodels.db/MODEL1310110023#_a1ded22d_67eb_4c5a_a040_2da8c3ab56d4
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: SHMT2
is: B4DJQ3
is encoded by: hsa:6472
type: Species
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110023#_4589d5f5_b61f_45cc_9e54_68add3a951d8
name: ALDH1A2
type: Species
initial amount: NaN
is: SBO:0000252
is: F5H2Y9
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8854
constant: false
has only substance units: false

metaM ptdcacoa m
is: HMDB06499
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C36H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C36H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-27(45)64-20-19-38-26(44)17-18-39-34(48)31(47)36(2,3)22-57-63(54,55)60-62(52,53)56-21-25-30(59-61(49,50)51)29(46)35(58-25)43-24-42-28-32(37)40-23-41-33(28)43/h23-25,29-31,35,46-47H,4-22H2,1-3H3,(H,38,44)(H,39,48)(H,52,53)(H,54,55)(H2,37,40,41)(H2,49,50,51)/p-4/t25-,29-,30-,31+,35-/m0/s1
name: pentadecanoyl Coenzyme A
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false

metaM nac c
boundary condition: false
initial amount: NaN
is: C00253
notes: FORMULA: C6H4NO2 CHARGE: -1
name: Nicotinate
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB01488
is: CHEBI:0
has only substance units: false
type: Species

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_a2f5a6fd_9abb_4aa1_9ba2_1835a48afaaf
constant: false
type: Species
has only substance units: false
is: P00491
is encoded by: hsa:4860
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: PNP

http://identifiers.org/biomodels.db/MODEL1310110023#_832e89bd_8579_49f6_8142_c518db956be2
initial amount: NaN
initial concentration: NaN
is: P28330
type: Species
name: ACADL
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:33
constant: false

metaM crm hs g
is: SBO:0000247
name: N-acylsphingosine
has only substance units: false
type: Species
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:52639
constant: false

metaR H2CO3D
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.1
reactant: MODEL1310110023#
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (761.1) or (771.1) or (377677.1) or (762.1) or (766.2) or (23632.1) or (766.1) or (771.2) or (759.1) or (768.1) or (760.1) SUBSYSTEM: Miscellaneous EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:11101628,PMID:11172051,PMID:11676494,PMID:14600151,PMID:7574487 NOTES:tv
kinetic law: MODEL1310110023#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
product: MODEL1310110023#
name: carboxylic acid dissociation

http://identifiers.org/biomodels.db/MODEL1310110023#_7516b949_1319_483d_afda_8f884847cf29
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
name: ACSL4
initial concentration: NaN
type: Species
initial amount: NaN
is: Q5JWV8
is encoded by: hsa:2182

metaM camp c
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
is: CHEBI:58165
boundary condition: false
is: HMDB00058
notes: FORMULA: C10H11N5O6P CHARGE: -1 INCHI: InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/p-1/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00434 EHMN_ABBREVIATION: C00575
has only substance units: false
name: 3',5'-cyclic AMP(1-)
is: SBO:0000247

metaR r1013
name: Transport reaction
type: Reaction
reversible: false
is: SBO:0000185
product: MODEL1310110023#
fast: false
reactant: MODEL1310110023#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12543708 NOTES:
kinetic law: MODEL1310110023#

metaR GAO1g
type: Reaction
modifier: MODEL1310110023#
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:for humans - seq predicted SLC transporters have been found to have O-acetylation activity on gangliosides NJ
name: Ganglioside O-acetylation
reversible: false
is described by: ECO:0000269
product: MODEL1310110023#
is: SBO:0000176

metaM cmp n
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: HMDB00095
initial amount: NaN
name: CMP(2-)
is: SBO:0000247
is: CHEBI:60377
type: Species
boundary condition: false
constant: false

metaM ctp n
constant: false
type: Species
is: HMDB00082
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: CHEBI:37563
name: CTP(4-)
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaR ACGAMK
product: MODEL1310110023#
fast: false
reversible: false
kinetic law: MODEL1310110023#
name: N-acetylglucosamine kinase
notes: GENE_ASSOCIATION: (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.59 Confidence Level: 4 AUTHORS: PMID:10824116 NOTES:
reactant: MODEL1310110023#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.59
type: Reaction
modifier: MODEL1310110023#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110023#_a89a8dc1_492b_4085_bef9_cc59e100822f
is: P50053
initial amount: NaN
name: KHK
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:3795
has only substance units: false

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

metaR PGDI
type: Reaction
product: MODEL1310110023#
fast: false
is version of: http://identifiers.org/ec-code/5.3.99.2
is: SBO:0000176
reversible: true
modifier: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
is version of: http://identifiers.org/ec-code/2.5.1.18
name: Prostaglandin-H2 D-isomerase [Precursor]
is described by: ECO:0000269
kinetic law: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_ee0d5547_45e8_4093_aa1c_e14635807eb9
boundary condition: true
is encoded by: hsa:84532
type: Species
has only substance units: false
constant: false
is: SBO:0000252
is: Q9NUB1
name: ACSS1
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_49c17b28_239a_4593_8ce8_4202b427bdef
is: SBO:0000252
name: PRPS1L1
is encoded by: hsa:221823
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is: P21108
type: Species
initial concentration: NaN

metaM gal c
has only substance units: false
is: HMDB00143
is: SBO:0000247
boundary condition: false
name: D-Galactose
type: Species
is: C00124
initial amount: NaN
is: CHEBI:0
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110023#_da1c214d_c502_4ce5_aa68_b8ae3955d90a
name: B3GALNT1
is encoded by: hsa:8706
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
is: O75752
has only substance units: false
type: Species

metaM phytcoa c
constant: false
boundary condition: false
is: HMDB01359
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57391
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
name: phytanoyl-CoA(4-)

metaR r1014
reversible: false
is: SBO:0000185
type: Reaction
name: Postulated transport reaction
fast: false
product: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12543708,PMID:17034878 NOTES:
kinetic law: MODEL1310110023#
is described by: ECO:0000000

metaR NH4t3r
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
is: SBO:0000185
fast: false
name: ammonia transport via proton antiport
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
type: Reaction
product: MODEL1310110023#
modifier: MODEL1310110023#

metaM co2 m
initial amount: NaN
is: HMDB01967
initial concentration: 1.0
name: CO2
is: SBO:0000247
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
type: Species
constant: false
has only substance units: false
boundary condition: false
is: C00011
is: CHEBI:16526

metaR AG13T14g
reactant: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
product: MODEL1310110023#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110023#
is: SBO:0000176
modifier: MODEL1310110023#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false

metaR VLCSr
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
fast: false
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
is: SBO:0000176
name: Very-long-chain-fatty-acid-CoA ligase
reversible: false
product: MODEL1310110023#
type: Reaction

metaR r0728
product: MODEL1310110023#
kinetic law: MODEL1310110023#
type: Reaction
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110023#

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

metaM HC01603 c
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
name: 10-Formyltetrahydrofolate
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: C00234
is: CHEBI:57454
constant: false

metaM ksi e
is: SBO:0000247
name: keratan sulfate I
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
is: HMDB00211
constant: false
is: CHEBI:17268
boundary condition: false
type: Species

metaR RE0344C
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.2.2
kinetic law: MODEL1310110023#
name: RE0344
modifier: MODEL1310110023#
fast: false
product: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.65
reactant: MODEL1310110023#
reversible: true

metaM dlnlcgcoa c
initial concentration: 1.0
boundary condition: false
constant: false
name: dihomo-gamma-linolenyl coenzyme A
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
is: CHEBI:27979

http://identifiers.org/biomodels.db/MODEL1310110023#_4d53f2cf_0b4a_42ce_a13a_ba6319012684
name: ALPI
boundary condition: true
is: P09923
type: Species
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:248
is: SBO:0000252
initial concentration: NaN

metaR UDPtl
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ
fast: false
reversible: true
product: MODEL1310110023#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: udp intracellular transport

metaM m2mn l
type: Species
has only substance units: false
notes: FORMULA: C26H45NO21 CHARGE: 0 INCHI: InChI=1/C26H45NO21/c1-6(32)27-11-15(36)20(10(5-31)42-23(11)41)46-25-18(39)22(14(35)8(3-29)44-25)48-26-19(40)21(13(34)9(4-30)45-26)47-24-17(38)16(37)12(33)7(2-28)43-24/h7-26,28-31,33-41H,2-5H2,1H3,(H,27,32)/t7-,8-,9-,10+,11+,12-,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23+,24-,25+,26+/m0/s1
boundary condition: false
name: (alpha-D-mannosyl)2-beta-D-mannosyl-N-acetylglucosamine
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB06537

metaR PRO1xm
reversible: false
is version of: http://identifiers.org/ec-code/1.5.99.8
is: SBO:0000176
reactant: MODEL1310110023#
product: MODEL1310110023#
kinetic law: MODEL1310110023#
fast: false
name: proline oxidase (NAD), mitochondrial
is described by: ECO:0000254
modifier: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:NCD

metaR S6T4g
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reversible: false
product: MODEL1310110023#
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
modifier: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_f9a39fdc_f3fc_4db6_a694_a6a1dd85eee1
is: Q8NEB9
name: PIK3C3
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5289

http://identifiers.org/biomodels.db/MODEL1310110023#_c98ca9fa_ab3c_4435_ab8c_2a532f8b8f2f
boundary condition: true
is encoded by: hsa:53354
constant: false
initial amount: NaN
type: Species
name: PANK1
is: SBO:0000252
is: Q8TE04
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_c76b738d_a2cc_4b2b_b2e9_e7258d07096b
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:270
is: SBO:0000252
has only substance units: false
is: P23109
name: AMPD1

metaR DGCHOLtx
type: Reaction
fast: false
name: bile acid intracellular transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_57831458_98ed_403d_a058_c2df83d7e2d3
initial amount: NaN
type: Species
is encoded by: hsa:9057
name: SLC7A6
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
is: Q92536

metaM HC01459 x
has only substance units: false
is: SBO:0000247
type: Species
name: 3alpha,7alpha,12alpha,24-Tetrahydroxy-5beta-cholestanoyl-CoA
initial concentration: 1.0
notes: FORMULA: C48H76N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-34,36,38-40,44,56-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/t24-,25?,26+,27-,28-,29+,30+,31?,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 EHMN_ABBREVIATION: C05450
boundary condition: false
is: CHEBI:27458
constant: false
initial amount: NaN

metaR PItx
reactant: MODEL1310110023#
name: Phosphate transporter, peroxisome
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110023#
product: MODEL1310110023#
fast: false

metaR THRGLNNaEx
product: MODEL1310110023#
is: SBO:0000185
reactant: MODEL1310110023#
is described by: ECO:0000269
name: L-threonine/L-glutamine Na-dependent exchange (Thr-L in)
modifier: MODEL1310110023#
fast: false
type: Reaction
reversible: false
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaR GNDer
is: SBO:0000176
name: phosphogluconate dehydrogenase, endoplasmic reticulum
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110023#
reversible: false
reactant: MODEL1310110023#
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.44 Confidence Level: 4 AUTHORS: PMID:2156506 NOTES:SMP Note no proton generation by the the reaction NCD
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_5af6b2f7_8c8b_43e5_8dee_d0bc9ff51c07
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:AV717590
has only substance units: false
initial amount: NaN
name: _AV717590_1_m
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110023#_821cf8bf_6bfa_4b48_a118_a5c0f4501a59
boundary condition: true
is: Q9UI40
initial amount: NaN
name: SLC24A2
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:25769

http://identifiers.org/biomodels.db/MODEL1310110023#_6db90f3e_30ba_4a38_b417_53db2d82ab57
has only substance units: false
constant: false
name: SLC33A1
initial concentration: NaN
is: O00400
is encoded by: hsa:9197
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN

metaM HC02214 e
initial amount: NaN
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
name: prostaglandin-f1alpha
is: CHEBI:28852
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0

metaR FAOXC165C164m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C16:5-->C16:4)m
type: Reaction

metaR LNLCt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
name: Linoleic acid (n-C18:2) transport in via diffusion
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110023#
fast: false
product: MODEL1310110023#
kinetic law: MODEL1310110023#

metaR FACOAL140i
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:JLR
reactant: MODEL1310110023#
name: fatty-acid--CoA ligase (tetradecanoate)
is: SBO:0000176
kinetic law: MODEL1310110023#
fast: false
type: Reaction

metaM hs deg13 l
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
is: HMDB01352
name: heparan sulfate, degradation product 13
is: CHEBI:17180
notes: FORMULA: C55H83N3O61S5 CHARGE: -6

metaM 3mob e
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
name: 3-methyl-2-oxobutanoate
is: CHEBI:11851
initial amount: NaN
is: HMDB00019
boundary condition: false
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
is: SBO:0000247

metaM HC00319 c
is: CHEBI:30794
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
name: Malonate
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
constant: false

metaR r1821
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110023#
type: Reaction
name: Y+LAT2 Utilized transport
product: MODEL1310110023#
is described by: ECO:0000000
modifier: MODEL1310110023#
fast: false

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

metaM tymsf c
initial concentration: 1.0
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: Tyramine O-sulfate
is: HMDB06409
has only substance units: false
constant: false

metaM itaccoa m
name: itaconyl-CoA(5-)
is: HMDB03377
is: SBO:0000247
is: CHEBI:57381
type: Species
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaM CE0713 m
is: HMDB02329
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
is: CHEBI:30623
has only substance units: false
name: 3-oxolinoleoyl-CoA

metaM hyptaur c
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: Hypotaurine
is: CHEBI:16668
is: HMDB00965
boundary condition: false
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519

metaR r2520
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418 NOTES:
is: SBO:0000185
fast: false
product: MODEL1310110023#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.1

metaM ksii core2 pre7 g
has only substance units: false
type: Species
constant: false
is: C00130
is: CHEBI:58053
notes: FORMULA: C67H108N5O51SX CHARGE: -2
is: SBO:0000247
boundary condition: false
is: HMDB00175
name: keratan sulfate II biosynthesis, precursor 7
initial amount: NaN
initial concentration: 1.0

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

metaR r0871
kinetic law: MODEL1310110023#
fast: false
type: Reaction
product: MODEL1310110023#
is described by: ECO:0000000
reversible: true
name: Diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409 NOTES:
is: SBO:0000185
reactant: MODEL1310110023#

metaM occoa m
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
is: C01944
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: HMDB01070
type: Species
name: Octanoyl-CoA (n-C8:0CoA)
is: CHEBI:57386

metaR IPDDIx
name: isopentenyl-diphosphate D-isomerase
notes: GENE_ASSOCIATION: (3422.1) or (91734.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ
reactant: MODEL1310110023#
product: MODEL1310110023#
is: SBO:0000176
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/5.3.3.2
fast: false
is described by: ECO:0000134
reversible: true
modifier: MODEL1310110023#
type: Reaction

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

metaR SGALSIDEtg
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
fast: false
name: sgalside hs intracellular transport
reversible: true
type: Reaction
product: MODEL1310110023#
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#

metaR N3Tg
is: SBO:0000176
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.4.1.122
notes: GENE_ASSOCIATION: (56913.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.122 Confidence Level: 0 AUTHORS: PMID:11677243 NOTES:NCD
reversible: false
name: N-acetylgalactosamine 3-beta-galactosyltransferase, Golgi apparatus
type: Reaction
fast: false
kinetic law: MODEL1310110023#
product: MODEL1310110023#
modifier: MODEL1310110023#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110023#_672dd9bb_89df_435d_a00b_001152b9d51e
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: Q53XN1
name: COX8A
has only substance units: false
constant: false
is encoded by: hsa:1351
initial concentration: NaN
type: Species

metaM 4mop m
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:17865
is: HMDB00695
has only substance units: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
constant: false
name: 4-methyl-2-oxopentanoate

http://identifiers.org/biomodels.db/MODEL1310110023#_e94619d7_28bf_4d8a_abf5_48cdcaec2192
is: SBO:0000252
initial amount: NaN
constant: false
is: Q96T66
has only substance units: false
type: Species
name: NMNAT3
boundary condition: true
initial concentration: NaN
is encoded by: hsa:349565

http://identifiers.org/biomodels.db/MODEL1310110023#_335a5149_c0ab_4698_8b77_51ded668235a
has only substance units: false
constant: false
name: PDE3A
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5139
is: Q14432

metaR r2521
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110023#
name: Utilized transport

metaM HC02214 c
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
boundary condition: false
initial amount: NaN
is: CHEBI:28852
has only substance units: false
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
name: prostaglandin-f1alpha

metaR FAOXC185C164m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:5-->C16:4)m
type: Reaction

metaR FAOXC121C101m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:1-->C10:1)m
type: Reaction

metaR EX hpdca LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptadecanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_8c7ba994_e73c_4253_9e55_8bb2e33253a8
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: TKTL1
is: B7Z7I0
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:8277
type: Species

metaM mercplaccys e
boundary condition: false
name: 3-mercaptolactate-cysteine disulfide
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
is: HMDB06512
type: Species
initial concentration: 1.0

metaR FCOAH
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
product: MODEL1310110023#
name: formyl coa hydrolase
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:11341778,PMID:11591435 NOTES:Note - formcoa formula is uncharged - the correct is FACOAH2 w/ forcoa NJ
type: Reaction
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110023#_944142f9_ff15_4326_a782_092f36081679
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
name: ACSL3
is: B3KMA6
is encoded by: hsa:2181

metaR LINKDEG4ly
name: degradation of proteoglycan linkage region, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
reversible: false
type: Reaction
product: MODEL1310110023#
is: SBO:0000176
reactant: MODEL1310110023#
is described by: ECO:0000000
kinetic law: MODEL1310110023#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_cfb53232_61e3_48a3_8d73_b325c5f130cd
is encoded by: hsa:1743
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
name: DLST
is: P36957
constant: false
initial amount: NaN

metaM ha pre1 e
is: SBO:0000247
name: hyaluronan biosynthesis, precursor 1
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
is: CHEBI:16126
type: Species
boundary condition: false
initial amount: NaN
constant: false

metaM tdcoa m
is: SBO:0000247
is: CHEBI:57385
name: Tetradecanoyl-CoA (n-C14:0CoA)
type: Species
constant: false
is: HMDB01521
initial concentration: 1.0
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
has only substance units: false
boundary condition: false
initial amount: NaN
is: C02593

metaR O2tm
type: Reaction
name: O2 transport (diffusion)
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
kinetic law: MODEL1310110023#
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110023#
reactant: MODEL1310110023#

metaM tymsf e
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
is: SBO:0000247
boundary condition: false
is: HMDB06409
constant: false
name: Tyramine O-sulfate

http://identifiers.org/biomodels.db/MODEL1310110023#_be149141_845d_4152_9f65_3cfce65d1177
boundary condition: true
name: _HG2846_HT2983_1_m
is encoded by: hsa:HG2846-HT2983
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_92edcd60_0c14_42f2_b64e_8cb45d1704b7
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AI926493
constant: false
is: SBO:0000252
name: _AI926493_1_c
boundary condition: true
type: Species

metaR EX thf LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5,6,7,8-Tetrahydrofolate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_4ee54718_f4e6_4b47_a3d9_741f45bc7b91
is: O95167
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4696
has only substance units: false
type: Species
name: NDUFA3
boundary condition: true
initial amount: NaN
constant: false

metaR UDPGD
is: SBO:0000176
reactant: MODEL1310110023#
type: Reaction
name: UDPglucose 6-dehydrogenase
reversible: false
modifier: MODEL1310110023#
is described by: ECO:0000304
kinetic law: MODEL1310110023#
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.1.1.22
notes: GENE_ASSOCIATION: (7358.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 1.1.1.22 Confidence Level: 2 AUTHORS: PMID:9296457,PMID:9737970 NOTES:JLR
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_1a26da51_1285_4ec8_8a18_aa07660f836c
type: Species
has only substance units: false
name: OGDH
initial amount: NaN
constant: false
is: SBO:0000252
is: Q02218
is encoded by: hsa:4967
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_790914fb_e4fe_49cf_a056_528a8ad4c582
initial concentration: NaN
name: PYCRL
is: Q53H96
constant: false
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:65263

http://identifiers.org/biomodels.db/MODEL1310110023#_ddd58f23_8372_4afa_907c_b93c8efbedf0
boundary condition: true
constant: false
name: NIT2
initial amount: NaN
is: Q9NQR4
is: SBO:0000252
type: Species
is encoded by: hsa:56954
has only substance units: false
initial concentration: NaN

metaR ALDD21
notes: GENE_ASSOCIATION: (224.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:8528251 NOTES:NJ
name: aldehyde dehydrogenase (pristanal, NAD)
product: MODEL1310110023#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
is described by: ECO:0000304
reversible: false
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
modifier: MODEL1310110023#

metaM ac m
is: HMDB00042
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:30089
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
initial amount: NaN
type: Species
name: acetate

http://identifiers.org/biomodels.db/MODEL1310110023#_ce1fe180_d3e5_4b27_bcac_952bf2d6a21a
is: SBO:0000252
type: Species
is encoded by: hsa:AA526438
initial amount: NaN
name: _AA526438_1_m
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true

metaR CO2tm
kinetic law: MODEL1310110023#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
is: SBO:0000185
is described by: ECO:0000000
name: CO2 transport (diffusion), mitochondrial
type: Reaction
fast: false
product: MODEL1310110023#
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_2302a86e_ae00_4c90_a707_213617c25961
initial concentration: NaN
name: UPP1
is: SBO:0000252
type: Species
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:7378
boundary condition: true

metaR GLXO2p
type: Reaction
product: MODEL1310110023#
reversible: false
is: SBO:0000176
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (54363.1) or (51179.2) or (51179.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.3.15 Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.3.15
name: glyoxylate oxidase, peroxisomal
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_196386d0_74e3_4228_a6ea_5871da88adf2
constant: false
is encoded by: hsa:113235
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
name: SLC46A1
is: SBO:0000252
is: Q96NT5

http://identifiers.org/biomodels.db/MODEL1310110023#_f9a48983_a5fb_4eb9_8634_d6cdcddf26fb
type: Species
is: P17516
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:1109
initial amount: NaN
is: SBO:0000252
name: AKR1C4

http://identifiers.org/biomodels.db/MODEL1310110023#_c99d1c73_6ee8_407c_a518_519fc480186e
boundary condition: true
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:2986
name: GUCY2F
is: P51841
has only substance units: false
is: SBO:0000252
initial amount: NaN

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

metaM fuc L l
initial amount: NaN
name: L-fucose
boundary condition: false
type: Species
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
is: SBO:0000247
is: CHEBI:18287
has only substance units: false
is: HMDB00174
initial concentration: 1.0
constant: false

metaR r0870
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
name: Facilitated diffusion
is version of: http://identifiers.org/ec-code/3.6.4.13
is described by: ECO:0000000
reactant: MODEL1310110023#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110023#
fast: false
product: MODEL1310110023#
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.6.1.1
is version of: http://identifiers.org/ec-code/2.7.7.72
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.4

metaM eicostet e
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB02177
name: eicosatetranoic acid
notes: FORMULA: C20H31O2 CHARGE: -1
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:36033
initial amount: NaN

metaR GLUt2m
fast: false
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (83733.1) or (8604.1) or (79751.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
type: Reaction
product: MODEL1310110023#
reversible: true
is: SBO:0000185
modifier: MODEL1310110023#
is described by: ECO:0000269
reactant: MODEL1310110023#
name: L-glutamate reversible transport via proton symport, mitochondrial

metaR GALT
product: MODEL1310110023#
reversible: true
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:1427861 NOTES:
name: galactose-1-phosphate uridylyltransferase
is described by: ECO:0000000
reactant: MODEL1310110023#
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.12
modifier: MODEL1310110023#
is: SBO:0000176
type: Reaction

metaM thcholstoic r
type: Species
boundary condition: false
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
is: CHEBI:18402
has only substance units: false
constant: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
initial amount: NaN
is: HMDB03873
is: SBO:0000247
initial concentration: 1.0

metaR CO2tp
reversible: true
product: MODEL1310110023#
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
type: Reaction
fast: false
name: CO2 peroxisomal transport
is: SBO:0000185

metaM 3mob m
is: CHEBI:11851
initial amount: NaN
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
name: 3-methyl-2-oxobutanoate
constant: false
is: SBO:0000247
is: HMDB00019

http://identifiers.org/biomodels.db/MODEL1310110023#_6736ae98_933f_4f6c_9334_2eea8e6302fb
boundary condition: true
initial amount: NaN
is encoded by: hsa:27068
name: PPA2
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_98ee2506_2c81_4480_87ee_a7bbbe00e0a3
is: P33897
initial amount: NaN
has only substance units: false
is encoded by: hsa:215
constant: false
name: ABCD1
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110023#_e90be32f_3080_4b05_846c_e00cebd2f4be
is: A8MU28
is: SBO:0000252
type: Species
is encoded by: hsa:8883
has only substance units: false
name: NAE1
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false

metaM 13 cis retn r
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
name: 13-cis-retinoate
constant: false
is: http://identifiers.org/pubchem.compound/7847414
initial amount: NaN
is: D00348
is: HMDB06219
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_1f8b30b3_777a_4e5c_8179_cbe1efd763bf
name: DHFR
initial amount: NaN
is: P00374
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:1719
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110023#_b7607cac_1db2_49f6_a5ea_e60bd5a77b76
boundary condition: true
name: PHYH
is: O14832
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:5264

metaR ALAR
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (11212.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 5.1.1.1 Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000212
product: MODEL1310110023#
is: SBO:0000176
type: Reaction
fast: false
name: alanine racemase
reversible: true
reactant: MODEL1310110023#

metaM hs deg12 l
is: CHEBI:17180
type: Species
is: SBO:0000247
is: HMDB01352
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
name: heparan sulfate, degradation product 12
notes: FORMULA: C55H82N3O64S6 CHARGE: -7

metaM crm hs c
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:52639
has only substance units: false
initial amount: NaN
type: Species
name: N-acylsphingosine
boundary condition: false
constant: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195

metaR GALU
fast: false
kinetic law: MODEL1310110023#
product: MODEL1310110023#
name: UTP-glucose-1-phosphate uridylyltransferase
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (7360.1) or (7359.1) or (7360.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.9 Confidence Level: 0 AUTHORS: PMID:9119383 NOTES:Human Y/N: Y
modifier: MODEL1310110023#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110023#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.7.9

metaR DUMPtn
is described by: ECO:0000000
name: dUMP nuclear transport
reversible: true
fast: false
product: MODEL1310110023#
type: Reaction
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaR CYSTHRNaEx
type: Reaction
name: L-cysteine/L-threonine Na-dependent exchange (Cys-L in)
kinetic law: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110023#
product: MODEL1310110023#
reversible: false
modifier: MODEL1310110023#
is described by: ECO:0000269
is: SBO:0000185

metaR r0549
is version of: http://identifiers.org/ec-code/1.6.5.3
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.6.99.3
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.1.1.17
kinetic law: MODEL1310110023#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110023#
fast: false

metaR SBTR
reactant: MODEL1310110023#
modifier: MODEL1310110023#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.2
name: D-sorbitol reductase
reversible: false
product: MODEL1310110023#
fast: false
kinetic law: MODEL1310110023#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (8574.1) or (10327.1) or (231.1) or (10327.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.21

http://identifiers.org/biomodels.db/MODEL1310110023#_07b18654_8492_4a8a_bc30_f24a008879e4
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:57468
is: Q9H2X9
type: Species
initial concentration: NaN
name: SLC12A5
initial amount: NaN
is: SBO:0000252

metaM HC00229 e
initial amount: NaN
is: SBO:0000247
is: CHEBI:28189
initial concentration: 1.0
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
constant: false
name: Isomaltose
type: Species
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110023#_c3d8be13_8150_4cd2_b758_80ff8631e709
is: B3KT19
is encoded by: hsa:5295
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
name: PIK3R1

http://identifiers.org/biomodels.db/MODEL1310110023#_751aacbc_151a_4f4c_8b98_a5ee1dbc1d29
has only substance units: false
type: Species
initial concentration: NaN
is: P55084
initial amount: NaN
name: HADHB
boundary condition: true
constant: false
is encoded by: hsa:3032
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110023#_d7103251_7af7_4e9c_bd18_b4383f7ddc38
is encoded by: hsa:7357
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
is: Q16739
boundary condition: true
name: UGCG
initial concentration: NaN
type: Species

metaR EX dmhptcrn LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2,6 dimethylheptanoyl carnitine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_66fb7f7c_6f8e_4e1d_b7b8_63dbf29c34a7
type: Species
is encoded by: hsa:11254
boundary condition: true
has only substance units: false
initial amount: NaN
name: SLC6A14
constant: false
initial concentration: NaN
is: SBO:0000252
is: Q9UN76

metaM utp e
type: Species
initial amount: NaN
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: CHEBI:46398
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB00285
name: UTP(4-)
boundary condition: false
is: SBO:0000247

metaR FAS180COA
name: fatty-acyl-CoA synthase (n-C18:0CoA)
product: MODEL1310110023#
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
kinetic law: MODEL1310110023#
fast: false
reactant: MODEL1310110023#
modifier: MODEL1310110023#

metaR FUMTSULtm
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
fast: false
is: SBO:0000185
reactant: MODEL1310110023#
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110023#
type: Reaction
name: Fumarate:thiosulfate antiport, mitochondrial
kinetic law: MODEL1310110023#
product: MODEL1310110023#

metaM vacc c
boundary condition: false
is: C08367
is: CHEBI:30828
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+
name: trans-vaccenate
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110023#_2949a3ba_717f_42a7_81ee_a60819cf1d9c
boundary condition: true
has only substance units: false
initial concentration: NaN
is: Q9BY49
name: PECR
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:55825
constant: false

metaM dhcholestanate c
is: HMDB00359
initial amount: NaN
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
has only substance units: false
is: SBO:0000247
is: CHEBI:16577
boundary condition: false
constant: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_3c87c2a0_2459_47dd_aa21_a554d4d0f476
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
constant: false
name: PNPO
has only substance units: false
is: Q9NVS9
initial amount: NaN
is encoded by: hsa:55163

http://identifiers.org/biomodels.db/MODEL1310110023#_b2c9a001_b726_4f81_b320_eed38a608b35
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q9NRF8
initial concentration: NaN
type: Species
is encoded by: hsa:56474
name: CTPS2
is: SBO:0000252
constant: false

metaR ILETAm
type: Reaction
is: SBO:0000176
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
name: isoleucine transaminase, mitochondrial
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.42
product: MODEL1310110023#
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#

metaM gua e
has only substance units: false
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
name: guanine
is: CHEBI:16235
initial amount: NaN
is: HMDB00132

metaR EX 10fthf6glu LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](6) exchange
type: Reaction

metaM CE5132 n
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:57923
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)

metaM occoa x
name: Octanoyl-CoA (n-C8:0CoA)
is: C01944
has only substance units: false
type: Species
boundary condition: false
is: HMDB01070
initial amount: NaN
is: CHEBI:57386
is: SBO:0000247
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
initial concentration: 1.0
constant: false

metaR r0321
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
is version of: http://identifiers.org/ec-code/6.3.5.2
product: MODEL1310110023#
is described by: ECO:0000000
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
modifier: MODEL1310110023#
reversible: false
reactant: MODEL1310110023#
fast: false
is: SBO:0000176
type: Reaction

metaR O2tp
type: Reaction
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
name: O2 transport, peroxisomal
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185

metaR EX hspg LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heparan sulfate proteoglycan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_26f0b694_c894_4d39_b560_a2e89805a01d
constant: false
is encoded by: hsa:NM 001929
boundary condition: true
has only substance units: false
name: _NM_001929_1_c
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_f0bd9200_4e58_4cc0_b764_68e12efe82e5
is: SBO:0000252
is encoded by: hsa:160728
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
is: Q8N695
constant: false
initial concentration: NaN
name: SLC5A8

metaM 5tedtricoa m
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C35H52N7O17P3S CHARGE: -4
is: SBO:0000247
name: 5,8,11-tetradecatrienoylcoa
type: Species
constant: false
boundary condition: false
is: HMDB02288
has only substance units: false

metaM vacc e
is: CHEBI:30828
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+
name: trans-vaccenate
is: SBO:0000247
type: Species

metaR EX mercplaccys LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-mercaptolactate-cysteine disulfide exchange
type: Reaction

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaR RE3269C
modifier: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.48
reactant: MODEL1310110023#
name: RE3269
fast: false
notes: GENE_ASSOCIATION: (8897.1) or (8897.3) or (8897.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:Recin 1 had irreversible version - PI35P3P - GPR from PI35P3P was added - May 2011 IT
product: MODEL1310110023#
reversible: true
kinetic law: MODEL1310110023#
type: Reaction

metaM 4nph e
type: Species
constant: false
name: 4-nitrophenolate
is: HMDB01232
is: CHEBI:57917
initial concentration: 1.0
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaM HC00319 m
type: Species
is: SBO:0000247
name: Malonate
has only substance units: false
initial amount: NaN
is: CHEBI:30794
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
constant: false
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110023#_c303400e_636f_438c_898e_c3a6d59c6824
has only substance units: false
is encoded by: hsa:4711
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
name: NDUFB5
initial concentration: NaN
constant: false
is: O43674

metaR r2380
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110023#
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
product: MODEL1310110023#

metaM gua c
is: HMDB00132
name: Guanine
type: Species
boundary condition: false
initial concentration: 1.0
is: C00242
is: SBO:0000247
is: CHEBI:16235
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242

metaR r0879
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11287335,PMID:11327718 NOTES:
is described by: ECO:0000000
name: TCDB:2.A.29.2.4 TCDB:2.A.29.16.1
is: SBO:0000185
product: MODEL1310110023#
type: Reaction
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
fast: false
reversible: false

metaR FAOXC227C226m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:7-->C22:6)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_6b785802_4518_403c_9b8e_f3fbecd2da17
is: Q8WYR1
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:23533
name: PIK3R5
initial amount: NaN
boundary condition: true
constant: false

metaR CERT2rt
name: ceramide transport protein
modifier: MODEL1310110023#
product: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.11.1
fast: false
reversible: true
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
reactant: MODEL1310110023#
type: Reaction

metaM 3docopencoa m
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB02288
name: 3,7,10,13,16-docosapentenoylcoa
initial amount: NaN
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_f0e9adce_c0e2_4bfa_a160_e83a1437525f
type: Species
is encoded by: hsa:9487
initial amount: NaN
name: PIGL
has only substance units: false
is: Q9Y2B2
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252

metaM c226crn m
initial concentration: 1.0
is: HMDB06510
initial amount: NaN
is: http://identifiers.org/pubchem.compound/127055
constant: false
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
has only substance units: false
name: cervonyl carnitine
boundary condition: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_e3abf6ee_1e6d_4fe2_8b75_c12d5dfcdf20
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:4245
constant: false
initial concentration: NaN
is: P26572
initial amount: NaN
type: Species
name: MGAT1

http://identifiers.org/biomodels.db/MODEL1310110023#_e2a66f12_db39_48e5_8d81_2baf75da70e6
is: Q02221
is encoded by: hsa:1339
is: SBO:0000252
name: COX6A2
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
type: Species

metaR G14T4g
reversible: false
fast: false
reactant: MODEL1310110023#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
modifier: MODEL1310110023#
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110023#
is described by: ECO:0000000
type: Reaction

metaR r0545
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
reactant: MODEL1310110023#
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.6.1.5
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
is: SBO:0000176
product: MODEL1310110023#

metaR EX idour LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-iduronate
type: Reaction

metaR O2tn
kinetic law: MODEL1310110023#
is: SBO:0000185
name: O2 nuclear transport
type: Reaction
reactant: MODEL1310110023#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110023#
fast: false

metaM 2amac c
name: 2-aminoacrylic acid
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C3H5NO2 CHARGE: 0 INCHI: InChI=1S/C3H5NO2/c1-2(4)3(5)6/h1,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00906 EHMN_ABBREVIATION: C02218
is: HMDB03609
is: SBO:0000247
is: CHEBI:17123
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_327a325f_993c_4bc7_91af_5bc7c1c24747
name: SLC25A6
initial concentration: NaN
boundary condition: true
is encoded by: hsa:293
type: Species
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: Q6I9V5

metaM pyr x
is: HMDB00243
is: C00022
is: http://identifiers.org/pubchem.compound/3324
name: pyruvate
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:15361
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

metaM lnlccoa c
has only substance units: false
is: http://identifiers.org/pubchem.compound/5462164
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
initial amount: NaN
is: SBO:0000247
constant: false
name: linoleic coenzyme A
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB01064

http://identifiers.org/biomodels.db/MODEL1310110023#_f391567a_ec68_404b_af90_99ce53e83529
boundary condition: true
has only substance units: false
type: Species
constant: false
name: HLCS
is: SBO:0000252
is: P50747
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3141

metaR r2382
reactant: MODEL1310110023#
product: MODEL1310110023#
kinetic law: MODEL1310110023#
is described by: ECO:0000000
modifier: MODEL1310110023#
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110023#_e8854756_9ca8_4b79_af0f_99044c35c283
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: C9JC79
is: SBO:0000252
name: SCP2
constant: false
is encoded by: hsa:6342
type: Species
boundary condition: true

metaM 4nph c
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:57917
constant: false
initial amount: NaN
name: 4-nitrophenolate
is: HMDB01232
is: SBO:0000247

metaR ACNACNGALGBSIDEtg
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
reversible: true
kinetic law: MODEL1310110023#
name: acnacngalgbside hs intracellular transport
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110023#

metaR GRTTx
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
reactant: MODEL1310110023#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.5.1.1
reversible: false
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
product: MODEL1310110023#
name: geranyltranstransferase

metaM fuc L c
name: L-fucose
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB00174
has only substance units: false
is: CHEBI:18287
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
boundary condition: false
is: SBO:0000247

metaR NODe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
fast: false
product: MODEL1310110023#
reactant: MODEL1310110023#
is: SBO:0000185
is described by: ECO:0000134
name: NODe
kinetic law: MODEL1310110023#
type: Reaction

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

metaR C226CPT1
fast: false
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110023#
is: SBO:0000176
reversible: false
type: Reaction
modifier: MODEL1310110023#
is described by: ECO:0000000
name: carnitine C22:6 transferase

http://identifiers.org/biomodels.db/MODEL1310110023#_ccb06400_b273_44e4_b093_e3223468dd22
is encoded by: hsa:1503
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: P17812
constant: false
name: CTPS1
has only substance units: false
type: Species

metaM galside hs c
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
is: SBO:0000247
initial concentration: 1.0
name: D-galactosyl-N-acylsphingosine
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
type: Species
is: CHEBI:12947

metaM ser D c
has only substance units: false
constant: false
initial amount: NaN
type: Species
name: D-serine
boundary condition: false
is: HMDB03406
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16523

metaM ac e
initial amount: NaN
name: acetate
type: Species
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
is: CHEBI:30089
is: HMDB00042
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

metaM CE2838 e
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
initial concentration: 1.0
boundary condition: false
name: maltononaose
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
is: http://identifiers.org/pubchem.compound/5041
is: C01936

metaM utp c
constant: false
initial concentration: 1.0
is: HMDB00285
initial amount: NaN
is: SBO:0000247
is: CHEBI:46398
is: C00075
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
has only substance units: false
name: UTP
boundary condition: false
type: Species

metaR BDMT U
name: GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (uterus)
notes: GENE_ASSOCIATION: (56052.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110023#
product: MODEL1310110023#
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.142
reversible: false
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_73975ac4_cd6a_4142_83ac_ca2b26730d50
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is: A3KLL5
initial concentration: NaN
type: Species
name: ATP1B1
constant: false
is encoded by: hsa:481

http://identifiers.org/biomodels.db/MODEL1310110023#_7163e8dc_6e37_431c_90a3_158f0d77b6b0
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6487
constant: false
is: Q5T4Y1
name: ST3GAL3

http://identifiers.org/biomodels.db/MODEL1310110023#_62931d16_79c2_42cc_bec7_67561b021f22
is: P15289
name: ARSA
is: SBO:0000252
is encoded by: hsa:410
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
constant: false

metaM acetol c
initial amount: NaN
has only substance units: false
name: hydroxyacetone
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h4H,2H2,1H3
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:27957
boundary condition: false
type: Species
constant: false
is: HMDB06961

http://identifiers.org/biomodels.db/MODEL1310110023#_139a2a48_5d1a_4f8e_b56c_7227f4714358
is: O95168
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:4710
initial amount: NaN
constant: false
name: NDUFB4
initial concentration: NaN

metaM CE5788 e
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
name: kinetensin 1-7
is: HMDB02710
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:27485
initial concentration: 1.0
constant: false

metaR UMPK7n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
is: SBO:0000176
product: MODEL1310110023#
reversible: true
fast: false
reactant: MODEL1310110023#
type: Reaction
name: UMP kinase (dGTP),nuclear

metaR r2384
is: SBO:0000185
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110023#
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110023#
reactant: MODEL1310110023#

metaR RE1532M
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
modifier: MODEL1310110023#
fast: false
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
name: RE1532
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
is: SBO:0000176

metaR GLUDym
modifier: MODEL1310110023#
is: SBO:0000176
is described by: ECO:0000269
name: glutamate dehydrogenase (NADP), mitochondrial
type: Reaction
reversible: true
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
is version of: http://identifiers.org/ec-code/1.4.1.3
reactant: MODEL1310110023#
fast: false
kinetic law: MODEL1310110023#

metaR C226CPT2
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
is: SBO:0000176
name: C226 transport into the mitochondria
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:TDV
is described by: ECO:0000000
product: MODEL1310110023#
reactant: MODEL1310110023#
modifier: MODEL1310110023#

metaM 3mob c
initial amount: NaN
boundary condition: false
is: HMDB00019
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
constant: false
name: 3-methyl-2-oxobutanoate
has only substance units: false
type: Species
is: CHEBI:11851
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110023#_b06538f8_e938_4db3_85f7_71d2f48bcc16
type: Species
is encoded by: hsa:4540
initial concentration: NaN
boundary condition: true
name: ND5
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
is: P03915

http://identifiers.org/biomodels.db/MODEL1310110023#_c5c6df42_85ae_48d7_895c_4e236b9da66f
is encoded by: hsa:219
is: SBO:0000252
is: P30837
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
name: ALDH1B1

metaM HC01842 c
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
name: Phosphodimethylethanolamine
is: CHEBI:31997

metaR r2385
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110023#
is described by: ECO:0000000
reversible: false
type: Reaction
modifier: MODEL1310110023#
reactant: MODEL1310110023#
product: MODEL1310110023#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_54b72e8b_6c09_4be9_a615_31fbbc262dd2
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:2530
is: Q9BYC5
name: FUT8
constant: false
type: Species
initial concentration: NaN
boundary condition: true

metaR r0541
type: Reaction
modifier: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
product: MODEL1310110023#
reversible: true
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
reactant: MODEL1310110023#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.1.5
kinetic law: MODEL1310110023#
is: SBO:0000176

metaR ACNACNGALGBSIDEte
kinetic law: MODEL1310110023#
fast: false
reactant: MODEL1310110023#
name: acnacngalgbside hs transport
product: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ

metaR RETH
type: Reaction
name: retinyl ester hydrolase
product: MODEL1310110023#
reversible: false
kinetic law: MODEL1310110023#
fast: false
notes: GENE_ASSOCIATION: (8228.1) SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:1503811,PMID:15955102 NOTES:IT
modifier: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.1.1.3

http://identifiers.org/biomodels.db/MODEL1310110023#_d238ece4_5501_4394_baad_e87afe9f76a2
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:83549
boundary condition: true
name: UCK1
is: Q5JT09
is: SBO:0000252
constant: false

metaR r2375
kinetic law: MODEL1310110023#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110023#
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_cec49879_ca79_4c21_82a9_cf6a5e567217
initial amount: NaN
name: HSD17B4
has only substance units: false
is encoded by: hsa:3295
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is: E9PB82
is: SBO:0000252

metaM tchola x
has only substance units: false
type: Species
constant: false
name: taurocholate
initial concentration: 1.0
is: CHEBI:36257
boundary condition: false
initial amount: NaN
is: HMDB00036
is: SBO:0000247
notes: FORMULA: C26H45NO7S CHARGE: 0 INCHI: InChI=1S/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122

metaM galside hs g
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
has only substance units: false
type: Species
name: D-galactosyl-N-acylsphingosine
boundary condition: false
initial concentration: 1.0
is: CHEBI:12947
initial amount: NaN
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110023#_4a6fba08_2963_4e93_9d65_2fc5b8784e7d
boundary condition: true
name: HMBS
is encoded by: hsa:3145
initial concentration: NaN
is: P08397
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_6d3dffe3_e06b_4cb9_b54e_5b6c28a1b0f4
is: SBO:0000252
has only substance units: false
is: O00476
is encoded by: hsa:10786
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: SLC17A3
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_9b9eeec1_7634_438a_9ee6_112c01644592
constant: false
initial amount: NaN
is encoded by: hsa:4124
boundary condition: true
is: Q16706
name: MAN2A1
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_4438f42d_1070_4744_86ee_a77a8b8cec14
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:6817
name: SULT1A1
boundary condition: true

metaM fmn c
is: HMDB01520
initial concentration: 1.0
boundary condition: false
is: CHEBI:58210
name: FMN
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
is: C00061
constant: false

metaM acgal l
type: Species
initial amount: NaN
initial concentration: 1.0
name: N-acetyl-D-galactosamine
constant: false
has only substance units: false
is: HMDB00212
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
is: CHEBI:28037
is: SBO:0000247
boundary condition: false

metaM fe2 e
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
constant: false
is: SBO:0000247
is: CHEBI:29033
is: C00023
has only substance units: false
is: HMDB00692
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
name: Fe2+

metaM lcts g
name: lactose
type: Species
is: HMDB00186
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:17716
initial concentration: 1.0
constant: false
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3-,4-,5+,6+,7-,8-,9-,10-,11?,12+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00220 EHMN_ABBREVIATION: C00243
initial amount: NaN

metaR r2374
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110023#
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
reversible: true

metaR PItg
kinetic law: MODEL1310110023#
product: MODEL1310110023#
name: phosphate transport, Golgi apparatus
fast: false
reactant: MODEL1310110023#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
reversible: false

metaR MMMm
product: MODEL1310110023#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (4594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES:TDV
kinetic law: MODEL1310110023#
fast: false
is version of: http://identifiers.org/ec-code/5.4.99.2
reactant: MODEL1310110023#
name: methylmalonyl-CoA mutase
modifier: MODEL1310110023#
is: SBO:0000176
reversible: true

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

metaM ksi deg15 l
is: CHEBI:12936
has only substance units: false
type: Species
constant: false
name: keratan sulfate I, degradation product 15
notes: FORMULA: C160H257N11O140S8 CHARGE: -8
initial amount: NaN
initial concentration: 1.0
is: HMDB00143
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110023#_1bf0e0a0_acd2_4fd4_98ff_b8ab0da0c789
initial concentration: NaN
is encoded by: hsa:1607
constant: false
name: DGKB
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true

metaM man6p c
is: CHEBI:17369
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
name: D-Mannose 6-phosphate
initial concentration: 1.0
type: Species
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
is: HMDB01078
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_d43cea5b_ec93_4a94_bc16_320f9985ebf9
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:2517
name: FUCA1
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
is: P04066

metaR r2377
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
product: MODEL1310110023#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
type: Reaction
is described by: ECO:0000000

metaM 56dura c
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
boundary condition: false
initial amount: NaN
name: 5,6-dihydrouracil
is: HMDB00076
constant: false
type: Species
has only substance units: false
is: CHEBI:15901
initial concentration: 1.0
is: SBO:0000247

metaM ins e
is: SBO:0000247
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
is: C00294
is: CHEBI:17596
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: Inosine
is: HMDB00195
initial amount: NaN

metaR UGALGTg
fast: false
product: MODEL1310110023#
type: Reaction
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
name: UDPgalactose:D-glucose 4-beta-D-galactosyltransferase, Golgi apparatus
reversible: false
is: SBO:0000176
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (3906.1) and (2683.1) or (8704.2) or (8704.1) SUBSYSTEM: Galactose metabolism EC Number: 2.4.1.22 Confidence Level: 4 AUTHORS: PMID:11419947 NOTES:NCD

metaM ac c
is: SBO:0000247
initial concentration: 1.0
name: acetate
is: HMDB00042
type: Species
initial amount: NaN
is: CHEBI:30089
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033

metaM lcts e
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
is: HMDB00186
initial concentration: 1.0
is: CHEBI:17716
is: C00243
is: SBO:0000247
name: Lactose
constant: false
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00220 EHMN_ABBREVIATION: C00243

metaM fmn e
notes: FORMULA: C17H19N4O9P CHARGE: -2
is: CHEBI:58210
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: FMN
has only substance units: false
type: Species
constant: false
is: C00061
is: HMDB01520

http://identifiers.org/biomodels.db/MODEL1310110023#_9d044e80_1d71_452e_9050_2f0a0c9764cb
type: Species
initial concentration: NaN
is: SBO:0000252
is: Q969N2
constant: false
initial amount: NaN
is encoded by: hsa:51604
boundary condition: true
has only substance units: false
name: PIGT

http://identifiers.org/biomodels.db/MODEL1310110023#_947adf66_8eb9_42ce_90a3_7c63752f3cae
constant: false
name: GLA
type: Species
is encoded by: hsa:2717
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: Q53Y83

metaR r2376
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
is described by: ECO:0000000
product: MODEL1310110023#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_1e87e469_8c24_4880_a5d2_10fd334e8ed8
initial amount: NaN
name: ME2
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is: P23368
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4200

http://identifiers.org/biomodels.db/MODEL1310110023#_42cc731d_958d_456a_a4cd_f2c32485c0d6
type: Species
boundary condition: true
constant: false
name: RPIA
initial concentration: NaN
is encoded by: hsa:22934
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: P49247

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

metaM noncoa m
name: nonanoylcoa
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB13028
is: C01942
has only substance units: false
notes: FORMULA: C30H48N7O17P3S CHARGE: -4
is: SBO:0000247
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_8f21c6b3_7d82_4bcf_9faf_47480743d908
is encoded by: hsa:2348
initial concentration: NaN
name: FOLR1
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110023#_1110a8ee_ae8e_4413_8659_7d36708a263d
constant: false
boundary condition: true
name: AKR1B1
initial concentration: NaN
is encoded by: hsa:231
type: Species
is: P15121
initial amount: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110023#_1e63d282_6665_4e4d_8025_c5af68260f15
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: SLC19A3
constant: false
initial concentration: NaN
is encoded by: hsa:80704
is: Q9BZV2
has only substance units: false
type: Species

metaM ser D e
is: SBO:0000247
is: HMDB03406
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
has only substance units: false
constant: false
name: D-serine
boundary condition: false
type: Species
is: CHEBI:16523
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_26ee1a52_1e5a_47b9_9f9e_cca32235b8eb
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:4706
type: Species
is: SBO:0000252
name: NDUFAB1
initial concentration: NaN
is: O14561
initial amount: NaN

metaM dec47dicoa m
has only substance units: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966
name: 4,7-decadienoylcoa

http://identifiers.org/biomodels.db/MODEL1310110023#_ef783fea_5098_4f5a_90f7_ab02131ab7d0
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:51809
name: GALNT7
is: Q86SF2
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false

metaR r2379
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110023#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
is described by: ECO:0000000

metaR GCALDD
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.5
name: Glycolaldehyde dehydrogenase
type: Reaction
fast: false
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.2.1.36
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:11434452 NOTES:JLR
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.2.1.3

metaR HYXNt
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
is: SBO:0000185
kinetic law: MODEL1310110023#
is described by: ECO:0000269
fast: false
type: Reaction
name: Hypoxanthine transport
product: MODEL1310110023#
reactant: MODEL1310110023#
reversible: true

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

metaR MCLOR
name: 3-Mercaptolactate:NAD+ oxidoreductase
is version of: http://identifiers.org/ec-code/1.1.1.27
reversible: true
product: MODEL1310110023#
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110023#
type: Reaction
fast: false
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (92483.1) or (3945.1 and 3939.1) or (55293.1) or (3948.2) or (3948.1) or (3945.1) or (160287.1) or (3939.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:7054184 NOTES:
reactant: MODEL1310110023#

metaR NH4tp
is described by: ECO:0000000
fast: false
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
reversible: true
is: SBO:0000185
name: ammonia peroxisomal transport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_17005a03_251c_47f9_95c6_58025525def7
name: ATIC
is: P31939
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:471
initial amount: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110023#_e7a63812_8f22_4320_96a0_87a76c20028a
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:22305
has only substance units: false
type: Species
name: _22305_2_c

metaM 2mop c
is: SBO:0000247
constant: false
is: HMDB01172
has only substance units: false
initial concentration: 1.0
is: CHEBI:57700
name: 2-methyl-3-oxopropanoate
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
initial amount: NaN
boundary condition: false
type: Species

metaR OCD11CRNCACT
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaR r2378
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
is described by: ECO:0000000
product: MODEL1310110023#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_bc0d2f69_3303_48c7_9426_affdd4096978
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: ALDH3A2
has only substance units: false
type: Species
constant: false
boundary condition: true
is: P51648
is encoded by: hsa:224

metaR EX 4nphsf LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenyl sulfate exchange
type: Reaction

metaM dolmanp U c
type: Species
constant: false
has only substance units: false
is: CHEBI:15809
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: Dolichyl phosphate D-mannose, human uterine homolog
initial concentration: 1.0

metaM galside hs l
name: D-galactosyl-N-acylsphingosine
type: Species
initial amount: NaN
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:12947
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110023#_28f40625_d03e_4fae_a343_1064140c98a3
initial concentration: NaN
is encoded by: hsa:5152
constant: false
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
name: PDE9A
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110023#_07adf4a9_c43b_4828_94f2_289947b85ec2
is: Q9BW60
is encoded by: hsa:64834
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
name: ELOVL1
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_b3d51745_a41e_4048_87f4_949323f617a6
has only substance units: false
is: Q01959
name: SLC6A3
initial amount: NaN
type: Species
is encoded by: hsa:6531
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false

metaR DCYTD
name: deoxycytidine deaminase
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.5
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (978.1) or (57379.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:14744791,PMID:15087440,PMID:7923172,PMID:8001985,PMID:8422236 NOTES:
type: Reaction
is: SBO:0000176
is described by: ECO:0000254
reversible: false
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
product: MODEL1310110023#

metaR 5ADTSTSTERONESte
reactant: MODEL1310110023#
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
name: sulfonated testosterone transport
product: MODEL1310110023#
kinetic law: MODEL1310110023#
fast: false

metaR LEUKTRA4tr
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
name: leukotriene intracellular transport
reversible: true
type: Reaction
fast: false
is: SBO:0000185

metaR EX dcyt LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxycytidine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_4272e085_a075_4e0c_8d78_1c03a0dcfa11
boundary condition: true
type: Species
initial amount: NaN
constant: false
name: ALDH1A3
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:220
is: P47895

http://identifiers.org/biomodels.db/MODEL1310110023#_599e6e3e_fc84_4755_b76e_7b8127621e0b
name: ACHE
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
is: P22303
boundary condition: true
initial concentration: NaN
is encoded by: hsa:43
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_e2e3cbf3_f011_45d2_81b9_e71f9420ce66
is encoded by: hsa:771
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
name: CA12
has only substance units: false
type: Species

metaM q10h2 c
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/6504740
is: HMDB13111
initial amount: NaN
name: Ubiquinol-10
has only substance units: false
constant: false

metaR GGT6
kinetic law: MODEL1310110023#
name: Gamma-glutamyltransferase
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
product: MODEL1310110023#
fast: false
reactant: MODEL1310110023#
reversible: true

metaR TYRTA
reversible: true
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
fast: false
modifier: MODEL1310110023#
reactant: MODEL1310110023#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.1
product: MODEL1310110023#
kinetic law: MODEL1310110023#
name: tyrosine transaminase

metaM CE2417 m
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB11123
is: SBO:0000247
type: Species
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
constant: false
initial concentration: 1.0
is: CHEBI:28387

metaM fe2 c
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
type: Species
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:29033
has only substance units: false
is: HMDB00692
initial concentration: 1.0
name: Fe2+
is: C00023
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_9e8fd20d_e309_4c57_873b_2d901c57fd2c
is: Q86SK9
is: SBO:0000252
name: SCD5
boundary condition: true
is encoded by: hsa:79966
initial amount: NaN
type: Species
has only substance units: false
constant: false
initial concentration: NaN

metaM apoC m
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
name: Apocarboxlase (no lys residue)
is: HMDB00182
initial amount: NaN
is: CHEBI:32551
type: Species
notes: FORMULA: XH CHARGE: 0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110023#_a8101397_cb12_41c1_b0e1_47d8625809b7
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
boundary condition: true
is: P31937
initial amount: NaN
name: HIBADH
has only substance units: false
is encoded by: hsa:11112

http://identifiers.org/biomodels.db/MODEL1310110023#_ed35c297_d9bf_4578_ab7b_8f49ba9ae2cc
is: Q6IBE6
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:6484
constant: false
has only substance units: false
name: ST3GAL4
initial concentration: NaN
initial amount: NaN

metaM Lcyst c
boundary condition: false
is: HMDB02757
type: Species
has only substance units: false
initial amount: NaN
name: L-cysteate(1-)
constant: false
is: SBO:0000247
notes: FORMULA: C3H6NO5S CHARGE: -1 INCHI: InChI=1S/C3H7NO5S/c4-2(3(5)6)1-10(7,8)9/h2H,1,4H2,(H,5,6)(H,7,8,9)/p-1/t2-/m0/s1 EHMN_ABBREVIATION: C00506
is: CHEBI:58090
initial concentration: 1.0

metaR NACHEX27ly
is: SBO:0000176
reversible: false
is described by: ECO:0000269
product: MODEL1310110023#
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12562784 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110023#
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal

metaR G14T21g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110023#
fast: false

metaM frdp c
is: C00448
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: SBO:0000247
constant: false
is: HMDB00961
name: Farnesyl diphosphate
boundary condition: false
initial concentration: 1.0
is: CHEBI:175763

metaM duri e
is: HMDB00012
has only substance units: false
type: Species
constant: false
is: C00526
is: CHEBI:16450
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: Deoxyuridine
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
initial concentration: 1.0

metaM q10h2 e
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
is: http://identifiers.org/pubchem.compound/6504740
is: SBO:0000247
is: HMDB13111
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: Ubiquinol-10

metaR MANtg
is: SBO:0000185
product: MODEL1310110023#
kinetic law: MODEL1310110023#
name: mannose efflux from Golgi apparatus
reactant: MODEL1310110023#
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000

metaM ppbng c
type: Species
notes: FORMULA: C10H13N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00588 EHMN_ABBREVIATION: C00931
name: Porphobilinogen
is: C00931
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58126
boundary condition: false
is: HMDB00245
has only substance units: false
constant: false

metaM 2hexdtetcoa m
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
is: SBO:0000247
type: Species
name: 2,7,10,13-hexadecatetraenoylcoa
is: HMDB02288
boundary condition: false

metaR BAAT1x
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
reactant: MODEL1310110023#
fast: false
type: Reaction
product: MODEL1310110023#
is: SBO:0000176
is described by: ECO:0000269
name: bile acid Coenzyme A: amino acid N-acyltransferase
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
is version of: http://identifiers.org/ec-code/2.3.1.65
reversible: false

metaR EX 2hb LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Hydroxybutyrate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_832f0215_a795_4a68_b1f4_a8c19f00142f
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
type: Species
is encoded by: hsa:5538
name: PPT1
is: Q6FGQ4
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110023#_c4da73ad_2653_487e_8a09_59b9c78fc0d2
boundary condition: true
is: SBO:0000252
constant: false
is: B4DPV0
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5236
name: PGM1

metaR 3DPHBH1
reversible: false
fast: false
reactant: MODEL1310110023#
is: SBO:0000176
type: Reaction
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11051212 NOTES:Used to make Ubiquinone-10 enzyme has not been identified yet. IT
name: Hydroxylation of 3-Decaprenyl-4-hydroxybenzoate (NADH)
kinetic law: MODEL1310110023#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110023#_b2c92672_74ad_4ca4_b5e6_2fd67b4830c0
is: Q9UKG4
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
name: SLC13A4
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:26266

metaM fe2 m
is: C00023
has only substance units: false
name: Fe2+
type: Species
is: HMDB00692
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
is: CHEBI:29033
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaM 4hoxpacd c
is: SBO:0000247
is: HMDB03767
boundary condition: false
constant: false
name: (4-hydroxyphenyl)acetaldehyde
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15621
type: Species
notes: FORMULA: C8H8O2 CHARGE: 0 INCHI: InChI=1S/C8H8O2/c9-6-5-7-1-3-8(10)4-2-7/h1-4,6,10H,5H2 EHMN_ABBREVIATION: C03765

metaM lneldccrn m
initial concentration: 1.0
boundary condition: false
constant: false
name: Linoelaidyl carnitine
has only substance units: false
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9+,13-12+
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB06461

metaR CYTK11n
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110023#
type: Reaction
is: SBO:0000176
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110023#
product: MODEL1310110023#
name: cytidylate kinase (dCMP,dGTP),nuclear
fast: false

http://identifiers.org/biomodels.db/MODEL1310110023#_079447e4_61ec_44b6_801b_48853b1c4567
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: SULT1A1
is encoded by: hsa:6817
constant: false

metaM eicostet c
initial concentration: 1.0
is: CHEBI:36033
notes: FORMULA: C20H31O2 CHARGE: -1
type: Species
has only substance units: false
initial amount: NaN
name: eicosatetranoic acid
is: SBO:0000247
boundary condition: false
is: HMDB02177
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_626d14c4_ca3a_4152_bfc1_efad88ff72fd
initial amount: NaN
is: Q9NST1
is encoded by: hsa:80339
constant: false
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
name: PNPLA3
initial concentration: NaN

metaM acgal c
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
initial concentration: 1.0
is: SBO:0000247
is: HMDB00212
name: N-acetyl-D-galactosamine
is: CHEBI:28037
constant: false

metaR EX leuktrB4 LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene B4 exchange
type: Reaction

metaM co e
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: carbon monoxide
is: CHEBI:17245
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB01361
type: Species

metaR GLAl
is described by: ECO:0000000
modifier: MODEL1310110023#
reversible: false
product: MODEL1310110023#
name: galactosidase, alpha
notes: GENE_ASSOCIATION: (2717.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.22 Confidence Level: 4 AUTHORS: PMID:11775551,PMID:11828341,PMID:15003450,PMID:2836863 NOTES:NJ
is version of: http://identifiers.org/ec-code/3.2.1.22
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
fast: false
is: SBO:0000176
type: Reaction

metaR TYROXDAc
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.6 Confidence Level: 4 AUTHORS: PMID:11336106,PMID:14697899,PMID:8255365 NOTES:SAB also 1.4.3.4
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.4.3.4
product: MODEL1310110023#
fast: false
reversible: false
type: Reaction
is: SBO:0000176
name: Tyramine:oxygen oxidoreductase(deaminating)(flavin-containing) (cytosol)
is described by: ECO:0000269
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#

metaM 2mb2coa m
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
type: Species
is: CHEBI:57337
initial amount: NaN
name: 2-methylcrotonoyl-CoA(4-)
is: HMDB02054
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110023#_ca6c8578_23af_48d4_acd2_d46dddf76828
initial concentration: NaN
type: Species
name: _AU149534_1_m
is encoded by: hsa:AU149534
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false

metaR C4STMO2r
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.170
name: C-4 methyl sterol oxidase
modifier: MODEL1310110023#
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.14.13.72
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (6307.1) or (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
is: SBO:0000176
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110023#_2b362b4c_29eb_4659_bdcb_4ebfbcb17366
is: SBO:0000252
constant: false
boundary condition: true
type: Species
name: GAD1
is encoded by: hsa:2571
initial concentration: NaN
is: Q99259
has only substance units: false
initial amount: NaN

metaR PItn
fast: false
reversible: true
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
name: phosphate transport, nuclear
is: SBO:0000185

metaR OXAtp
reactant: MODEL1310110023#
product: MODEL1310110023#
name: oxalate transport out of peroxisome
reversible: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
kinetic law: MODEL1310110023#

metaM mi1345p c
constant: false
is: HMDB01059
is: CHEBI:57895
is: SBO:0000247
notes: FORMULA: C6H8O18P4 CHARGE: -8 INCHI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/p-8/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C01272
name: 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110023#_d0ded8e6_8f2e_4cce_a23f_b230946827b0
is encoded by: hsa:50940
is: Q9HCR9
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
name: PDE11A
initial amount: NaN

metaR EX udp LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_c032da31_c21b_4169_8293_8b4fb9491e8d
boundary condition: true
name: CHAT
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:1103
constant: false
initial amount: NaN
is: Q6LEN6

metaM pre prot r
constant: false
is: HMDB03125
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
name: glycophosphatidylinositol (GPI)-anchored protein precursor
is: SBO:0000247
is: CHEBI:16240
notes: FORMULA: XY CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110023#_26a10bc6_57dc_41df_96fd_e76520993390
is: P00439
boundary condition: true
is encoded by: hsa:5053
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: PAH
type: Species
constant: false
initial amount: NaN

metaR SUCOASm
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/6.2.1.5
is version of: http://identifiers.org/ec-code/6.2.1.4
name: Succinate--CoA ligase (ADP-forming)
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
is: SBO:0000176
reactant: MODEL1310110023#

metaM paps g
has only substance units: false
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
initial concentration: 1.0
is: SBO:0000247
is: HMDB01134
type: Species
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
boundary condition: false
is: CHEBI:58339
constant: false
initial amount: NaN

metaR OROTGLUt
reversible: true
reactant: MODEL1310110023#
name: OROTGLUt
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
type: Reaction
product: MODEL1310110023#
kinetic law: MODEL1310110023#
is: SBO:0000185

metaR PROt4 2 r
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
is described by: ECO:0000006
fast: false
product: MODEL1310110023#
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reactant: MODEL1310110023#
type: Reaction
name: Proline transport (sodium symport) (2:1)

metaR LEUKTRE4t
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
name: leukotriene E4 transport
is: SBO:0000185
product: MODEL1310110023#
type: Reaction
reactant: MODEL1310110023#

metaR AG13T15g
fast: false
product: MODEL1310110023#
reversible: false
reactant: MODEL1310110023#
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
modifier: MODEL1310110023#

metaR FAOXTC122TC101m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C12:2-->C10:1)m
type: Reaction

metaM co c
type: Species
name: carbon monoxide
is: SBO:0000247
is: CHEBI:17245
initial amount: NaN
constant: false
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
boundary condition: false
is: HMDB01361
initial concentration: 1.0
has only substance units: false

metaR CSAPASEly
product: MODEL1310110023#
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
type: Reaction
reversible: false
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
is described by: ECO:0000000
name: chondroitin sulfate A proteoglycan protease, lysosome (endosome)

metaM sql r
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
is: CHEBI:15440
boundary condition: false
has only substance units: false
constant: false
type: Species
is: HMDB00256
initial amount: NaN
name: squalene
is: SBO:0000247
initial concentration: 1.0

metaM tdcoa c
is: SBO:0000247
initial amount: NaN
name: Tetradecanoyl-CoA (n-C14:0CoA)
is: CHEBI:57385
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
is: C02593
has only substance units: false
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB01521

http://identifiers.org/biomodels.db/MODEL1310110023#_6fecc372_0628_469b_940e_50550049074c
is: SBO:0000252
boundary condition: true
is: A8K761
constant: false
name: NDUFB10
is encoded by: hsa:4716
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaM occoa c
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
constant: false
is: HMDB01070
initial amount: NaN
name: Octanoyl-CoA (n-C8:0CoA)
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
is: C01944
initial concentration: 1.0
is: CHEBI:57386

metaM hdcea e
is: SBO:0000247
constant: false
is: HMDB03229
has only substance units: false
name: Hexadecenoate (n-C16:1)
type: Species
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:32372

metaM hs deg9 l
constant: false
is: HMDB06355
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
name: heparan sulfate, degradation product 9
is: SBO:0000247
notes: FORMULA: C61H87N3O76S8 CHARGE: -10
boundary condition: false
is: CHEBI:18268

metaR PNTEH
name: Hydrolase Class ( RXN R02973)
reversible: false
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
type: Reaction
fast: false
modifier: MODEL1310110023#
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.5.1.92
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) SUBSYSTEM: CoA catabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10567687,PMID:11491533 NOTES:EC 3.5.1- KEGG RXN R02973 RM

http://identifiers.org/biomodels.db/MODEL1310110023#_6dff9e54_1980_48c6_ac2e_2b00f7f2cd5c
constant: false
is encoded by: hsa:W74642
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: _W74642_1_c

http://identifiers.org/biomodels.db/MODEL1310110023#_76700529_9947_450c_9ba5_59fb50d610cb
is encoded by: hsa:280
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
name: AMY2B
is: P19961

metaM cdpdag hs c
type: Species
name: CDP-diacylglycerol(2-)
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58332

metaR RE1517M
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is version of: http://identifiers.org/ec-code/1.3.99.13
kinetic law: MODEL1310110023#
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
name: RE1517
modifier: MODEL1310110023#
is: SBO:0000176
type: Reaction
product: MODEL1310110023#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_e7dfa139_f50a_4c59_90c4_a6e92a2bd1f9
is encoded by: hsa:51166
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
name: AADAT
initial amount: NaN
is: Q8N5Z0
type: Species
initial concentration: NaN

metaR 2AMACHYD
is: SBO:0000176
kinetic law: MODEL1310110023#
type: Reaction
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:500639 NOTES:SAB see PMID 500639: this reaction is spontaneous
fast: false
is described by: ECO:0000000
reactant: MODEL1310110023#
reversible: false
name: 2-Aminoacrylate hydrolysis

metaR r2526
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110023#
fast: false
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
reversible: true
product: MODEL1310110023#

metaM apoC Lys btn m
is: C05552
has only substance units: false
constant: false
notes: FORMULA: C16H27N4O3SX CHARGE: 0
is: http://identifiers.org/pubchem.compound/7886
boundary condition: false
type: Species
is: HMDB03134
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)

metaR FOAXC122C101x
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:2-->C10:1)x
type: Reaction

metaR BALABETAtc
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of beta alanine into the intestinal cells by beta transport system
type: Reaction

metaM m7mpdol U r
notes: FORMULA: C1665H2740N20O570P20 CHARGE: -20
initial concentration: 1.0
is: CHEBI:37636
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
name: (alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog

metaM oagd3 hs e
is: HMDB02168
type: Species
has only substance units: false
is: CHEBI:18421
boundary condition: false
initial concentration: 1.0
name: 9-O-Acetylated GD3
constant: false
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_db0263cf_c36b_4aee_99c9_02bdec036e48
initial amount: NaN
name: PPA2
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:27068
boundary condition: true
type: Species
constant: false

metaR FAOXC164GC163m
kinetic law: MODEL1310110023#
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)gm
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_f622612b_fcad_4afb_ab79_0dc8fb6acac5
is: P48735
initial concentration: NaN
constant: false
is encoded by: hsa:3418
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
name: IDH2

http://identifiers.org/biomodels.db/MODEL1310110023#_8b4ee342_86eb_4e70_9ce7_7ba7d5831c59
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:411
type: Species
is: P15848
name: ARSB
initial amount: NaN
constant: false

metaR r2525
fast: false
reversible: true
reactant: MODEL1310110023#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110023#
kinetic law: MODEL1310110023#

metaR EX lnlncg LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gamma-linolenic acid exchange
type: Reaction

metaM duri c
boundary condition: false
is: CHEBI:16450
constant: false
is: C00526
type: Species
is: SBO:0000247
name: Deoxyuridine
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB00012

metaR S2L2N2M2MASNtly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: false
name: s2l2n2m2masn transport, extracellular to lysosome
reactant: MODEL1310110023#
is: SBO:0000185
kinetic law: MODEL1310110023#
fast: false
type: Reaction
product: MODEL1310110023#
is described by: ECO:0000000

metaR AMETr
product: MODEL1310110023#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
reversible: true
name: S-Adenosyl-L-methionine intracellular diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_8570cff5_c4f6_4110_ad99_87e9ca6192e5
is encoded by: hsa:2876
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
name: GPX1
constant: false
initial amount: NaN
is: P07203

http://identifiers.org/biomodels.db/MODEL1310110023#_b5b84ff9_9689_4033_bbf9_4bca619b2b04
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:123041
initial amount: NaN
type: Species
name: SLC24A4
is: SBO:0000252

metaM 2mop m
is: SBO:0000247
has only substance units: false
is: CHEBI:57700
is: HMDB01172
initial concentration: 1.0
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
initial amount: NaN
type: Species
constant: false
boundary condition: false
name: 2-methyl-3-oxopropanoate

metaM hdcea c
has only substance units: false
is: SBO:0000247
constant: false
name: Hexadecenoate (n-C16:1)
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
type: Species
initial concentration: 1.0
is: HMDB03229
boundary condition: false
initial amount: NaN
is: CHEBI:32372

metaR SGALSIDEtl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
is described by: ECO:0000000
kinetic law: MODEL1310110023#
reversible: true
reactant: MODEL1310110023#
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110023#
name: sgalside hs intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110023#_c5bb0c90_ccf2_4830_865a_e3031250c2fe
initial amount: NaN
type: Species
is: Q00796
is: SBO:0000252
name: SORD
is encoded by: hsa:6652
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_2b172a83_5283_4e3c_b496_e452398d4d92
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
name: ACAA1
has only substance units: false
is: Q96CA6
is encoded by: hsa:30
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_e55cf8a0_d19b_4910_b645_4a4f3321decf
has only substance units: false
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6581
name: SLC22A3
is: SBO:0000252
is: Q5SYN6
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110023#_8c3f734d_3a0e_4b33_af56_4207205ab701
is encoded by: hsa:4122
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
is: Q9P1E4
initial concentration: NaN
name: MAN2A2
boundary condition: true
has only substance units: false

metaM L2aadp6sa c
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:17917
is: HMDB01263
is: SBO:0000247
type: Species
initial amount: NaN
name: L-allysine
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_164eec41_39a0_457b_961d_ec0261e62287
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:7296
name: TXNRD1
type: Species
boundary condition: true

metaR EX pheacgln LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-N-Phenylacetyl-L-glutamine exchange
type: Reaction

metaR r1020
reactant: MODEL1310110023#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110023#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
reversible: true
product: MODEL1310110023#
name: Postulated transport reaction

metaM 3docopencoa x
name: 3,7,10,13,16-docosapentenoylcoa
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
is: SBO:0000247
type: Species
constant: false
boundary condition: false
initial amount: NaN
is: HMDB02288

metaR 3DSPHR
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (2531.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 1.1.1.102 Confidence Level: 4 AUTHORS: NOTES:
fast: false
type: Reaction
is described by: ECO:0000269
product: MODEL1310110023#
reversible: false
name: 3-Dehydrosphinganine reductase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.102
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_30dc6a02_a64b_4d6b_b1c2_e53a06aa288f
is: SBO:0000252
initial amount: NaN
is: Q02218
type: Species
has only substance units: false
name: OGDH
constant: false
is encoded by: hsa:4967
boundary condition: true
initial concentration: NaN

metaR r1492
is described by: ECO:0000000
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reversible: false
product: MODEL1310110023#
reactant: MODEL1310110023#
name: Utilized transport
type: Reaction
is: SBO:0000185
fast: false

metaR ABO1g
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.37
is described by: ECO:0000269
product: MODEL1310110023#
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
is: SBO:0000176

metaM oagd3 hs g
is: HMDB01514
is: CHEBI:17315
has only substance units: false
boundary condition: false
is: C00329
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: 9-O-Acetylated GD3
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_a1f90888_6a4a_47dc_b31a_4b1c56f935b9
is: F5GWS5
name: ADCY10
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:55811
constant: false

metaR r0754
modifier: MODEL1310110023#
fast: false
product: MODEL1310110023#
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
reactant: MODEL1310110023#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
reversible: true
type: Reaction
kinetic law: MODEL1310110023#

metaR S6T3g
is version of: http://identifiers.org/ec-code/2.8.2.21
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.8.2.17
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
modifier: MODEL1310110023#
is described by: ECO:0000000
fast: false
product: MODEL1310110023#
kinetic law: MODEL1310110023#
reversible: false

metaR NAt
reactant: MODEL1310110023#
modifier: MODEL1310110023#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (6526.1) or (6523.1) or (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11024018,PMID:11034615,PMID:12679487,PMID:12748858,PMID:1372904,PMID:15546855,PMID:2490366,PMID:7537337,PMID:7789985,PMID:8063771,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:
name: sodium transport (uniport)
fast: false
type: Reaction
product: MODEL1310110023#
is described by: ECO:0000269
kinetic law: MODEL1310110023#

metaM oagd3 hs c
initial concentration: 1.0
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
is: HMDB01514
name: 9-O-Acetylated GD3
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
is: CHEBI:17315
boundary condition: false
is: C00329

metaM hestratriol e
is: SBO:0000247
name: 4,17 dihydroxy estradiol
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
boundary condition: false
is: HMDB05896
initial amount: NaN
constant: false

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_7eeb539e_ce63_402f_8b1a_8eaa3b690c18
has only substance units: false
is encoded by: hsa:6818
boundary condition: true
initial concentration: NaN
type: Species
is: Q1ET61
is: SBO:0000252
constant: false
initial amount: NaN
name: SULT1A3

http://identifiers.org/biomodels.db/MODEL1310110023#_92fed8f3_6fbf_4eec_9a39_5acf45e68b1c
has only substance units: false
constant: false
is: B7Z5G2
type: Species
is encoded by: hsa:2629
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: GBA

metaM ksi pre16 g
name: keratan sulfate I biosynthesis, precursor 16
is: CHEBI:58053
type: Species
is: HMDB00175
is: C00130
notes: FORMULA: C157H253N11O124S4X CHARGE: -5
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110023#_cd7e5582_6055_4732_b5d3_e83383949ece
is: SBO:0000252
boundary condition: true
has only substance units: false
name: PPAP2A
is encoded by: hsa:8611
initial amount: NaN
initial concentration: NaN
is: G3XA95
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_02ee6ae6_9afc_42d1_b2ec_41eb6cdddf5e
name: GCK
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2645
initial amount: NaN
has only substance units: false
is: Q53Y25
constant: false
initial concentration: NaN

metaR DNDPt38m
name: dUTP transport via dUDP antiport
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
product: MODEL1310110023#
modifier: MODEL1310110023#
reversible: false
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269

metaM pi g
is: SBO:0000247
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial concentration: 1.0
constant: false
is: HMDB00973
boundary condition: false
has only substance units: false
initial amount: NaN
name: hydrogenphosphate
is: CHEBI:43474
type: Species

metaM met L e
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
is: CHEBI:16643
boundary condition: false
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
is: HMDB00696
name: L-methionine

metaR r0755
is described by: ECO:0000000
kinetic law: MODEL1310110023#
is: SBO:0000176
fast: false
reversible: true
product: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (37.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:1898068 NOTES:
reactant: MODEL1310110023#
modifier: MODEL1310110023#
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5

http://identifiers.org/biomodels.db/MODEL1310110023#_255a13e4_4c78_434a_a362_5813bc316047
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: ST3GAL3
type: Species
boundary condition: true
constant: false
is encoded by: hsa:6487
is: Q5T4W8

http://identifiers.org/biomodels.db/MODEL1310110023#_66bfe3f0_a572_4293_b850_99db9b9dc7be
is: SBO:0000252
is: Q7LG56
is encoded by: hsa:50484
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
name: RRM2B
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_cae45421_1ca5_4fba_b887_fd6944807b4a
name: PDE9A
boundary condition: true
is encoded by: hsa:5152
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_32be4c0b_345d_4a42_b788_32c48d4fe17b
is encoded by: hsa:4128
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: Q53YE7
initial concentration: NaN
type: Species
constant: false
name: MAOA

http://identifiers.org/biomodels.db/MODEL1310110023#_50a9b05c_a1a8_48c4_b5f0_59554d3f7469
is: O43677
constant: false
name: NDUFC1
initial amount: NaN
boundary condition: true
is encoded by: hsa:4717
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species

metaR r0860
is version of: http://identifiers.org/ec-code/4.1.2.27
name: Utilized transport
is: SBO:0000185
kinetic law: MODEL1310110023#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110023#
fast: false
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1459,PMID:14598172,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
product: MODEL1310110023#

metaR RE1254C
name: RE1254
is: SBO:0000176
reactant: MODEL1310110023#
fast: false
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
type: Reaction
kinetic law: MODEL1310110023#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110023#_dd8f848c_2736_459a_9a84_fe24ea44b55d
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
type: Species
name: GMPR
is encoded by: hsa:2766
initial amount: NaN
is: P36959

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_a81d210f_1f78_4501_beca_1452df51378c
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:760
initial concentration: NaN
name: CA2
is: SBO:0000252
is: P00918
type: Species

http://identifiers.org/biomodels.db/MODEL1310110023#_b70cf506_9971_4ef2_92a9_fe448c7b6390
initial amount: NaN
boundary condition: true
name: UEVLD
type: Species
is encoded by: hsa:55293
is: SBO:0000252
is: Q8IX04
constant: false
has only substance units: false
initial concentration: NaN

metaR RE1533M
product: MODEL1310110023#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110023#
reversible: true
name: RE1533
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000

metaM nadph x
is: SBO:0000247
is: CHEBI:57783
constant: false
type: Species
is: HMDB00221
initial concentration: 1.0
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
has only substance units: false
boundary condition: false
name: Nicotinamide adenine dinucleotide phosphate - reduced
initial amount: NaN
is: C00005

metaM apoC c
type: Species
is: HMDB11111
has only substance units: false
is: SBO:0000247
is: CHEBI:33190
name: Apocarboxlase (no lys residue)
initial concentration: 1.0
notes: FORMULA: XH CHARGE: 0
initial amount: NaN
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110023#_29bb82f4_a15a_4c99_ab2d_b9bdab57e2ca
name: ADH1A
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:124
has only substance units: false
is: P07327
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_14b79fa5_5914_4f19_9d61_3c2fe599faca
name: PLCG1
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
is: P19174
constant: false
is encoded by: hsa:5335
boundary condition: true

metaR EX 34hpp
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_018f473b_6013_4bc6_a967_3f946b104250
has only substance units: false
type: Species
is encoded by: hsa:9334
name: B4GALT5
initial concentration: NaN
is: O43286
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_df51f31a_88bd_444e_bc77_1bad262b2719
is encoded by: hsa:240
has only substance units: false
type: Species
name: ALOX5
is: P09917
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252

metaR GLUDxm
fast: false
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
kinetic law: MODEL1310110023#
is described by: ECO:0000269
is: SBO:0000176
name: glutamate dehydrogenase (NAD) (mitochondrial)
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.4.1.3
reversible: true
type: Reaction
modifier: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_27e36662_f191_4297_aeb0_bc03f54aa476
name: PDE5A
is encoded by: hsa:8654
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
type: Species

metaM hestratriol c
name: 4,17 dihydroxy estradiol
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
boundary condition: false
type: Species
is: HMDB05896
initial amount: NaN

metaR CYTK9n
fast: false
product: MODEL1310110023#
name: cytidylate kinase (CMP,dCTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110023#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110023#_59c3ec68_2751_4383_87c4_79585bfa1f7b
is: O75106
name: AOC2
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:314
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
constant: false

metaR GCHOLAtx
reactant: MODEL1310110023#
reversible: true
is described by: ECO:0000000
product: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
kinetic law: MODEL1310110023#
fast: false
is: SBO:0000185
name: bile acid intracellular transport

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_89e95488_7d90_4c6a_89d7_b0095576455b
boundary condition: true
constant: false
is: Q86SR1
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:55568
name: GALNT10

metaR GGT5r
reversible: true
type: Reaction
name: Gamma-glutamyltransferase 5
is version of: http://identifiers.org/ec-code/2.3.2.2
reactant: MODEL1310110023#
modifier: MODEL1310110023#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (2687.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:18357468,PMID:18357469,PMID:6120203 NOTES:Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). NJ
is: SBO:0000176
kinetic law: MODEL1310110023#
fast: false
product: MODEL1310110023#

metaR PSt3
kinetic law: MODEL1310110023#
fast: false
type: Reaction
is: SBO:0000185
name: phosphatidylserine transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
reversible: true
reactant: MODEL1310110023#
product: MODEL1310110023#
is described by: ECO:0000269

metaR FORtr
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110023#
name: FOR transporter, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
product: MODEL1310110023#
reversible: true
kinetic law: MODEL1310110023#
fast: false
is: SBO:0000185

metaR TTDCAtr
name: tetradecanoate (transport)
reversible: true
fast: false
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
kinetic law: MODEL1310110023#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110023#
is described by: ECO:0000269

metaM 5adtststerones e
boundary condition: false
constant: false
is: HMDB06278
initial amount: NaN
has only substance units: false
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
is: SBO:0000247
type: Species
initial concentration: 1.0
name: 5alpha-Dihydrotestosterone sulfate

metaR GGH 5DHFe
is: SBO:0000176
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
is described by: ECO:0000000
modifier: MODEL1310110023#
kinetic law: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.4.19.9
reactant: MODEL1310110023#
type: Reaction
product: MODEL1310110023#
fast: false
reversible: false
name: Gamma-glutamyl hydrolase (5DHF), extracellular

http://identifiers.org/biomodels.db/MODEL1310110023#_1848e90d_1af8_482d_a693_0108abf345f9
is: Q9BWD1
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:39
boundary condition: true
constant: false
name: ACAT2

metaR r2511
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
name: Utilized transport
product: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110023#_c36c0a5a_3c6c_43da_9519_f3b0613c4a12
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:AI469183
type: Species
name: _AI469183_1_x
is: SBO:0000252
has only substance units: false

metaM hs deg1 l
is: HMDB01352
name: heparan sulfate, degradation product 1
has only substance units: false
notes: FORMULA: C79H115N5O99S11 CHARGE: -12
is: SBO:0000247
constant: false
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17180

metaR SO4tl
fast: false
is: SBO:0000185
product: MODEL1310110023#
type: Reaction
reactant: MODEL1310110023#
name: Sulfate transport (lysosome)
kinetic law: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
is described by: ECO:0000269
reversible: true

metaR D LACt2
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
reactant: MODEL1310110023#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
reversible: true
is: SBO:0000185
name: D-lactate transport via proton symport
fast: false
product: MODEL1310110023#

metaM HC01410 m
name: (2E)-Hexenoyl-CoA
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:28706
has only substance units: false
initial concentration: 1.0
constant: false
type: Species

metaR FATP3t
reversible: true
fast: false
modifier: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
product: MODEL1310110023#
type: Reaction
name: fatty acid electroneutral transport
is: SBO:0000185
kinetic law: MODEL1310110023#
is described by: ECO:0000269

metaM dgsn c
is: HMDB00085
name: Deoxyguanosine
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
is: CHEBI:17172
is: SBO:0000247
initial concentration: 1.0
is: C00330
constant: false
type: Species

metaR EX pheme LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for heme
type: Reaction

metaM CE5854 e
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
constant: false
initial amount: NaN
name: gama-CEHC-glucuronide
has only substance units: false
type: Species
is: CHEBI:27485
is: SBO:0000247
initial concentration: 1.0
is: HMDB02710
boundary condition: false

metaM paps c
boundary condition: false
has only substance units: false
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
is: HMDB01134
is: SBO:0000247
initial amount: NaN
is: CHEBI:58339
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
constant: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110023#_e070c22d_1412_4507_b394_0343f53b51bc
has only substance units: false
initial amount: NaN
name: GSTZ1
is: A6NED0
constant: false
boundary condition: true
is encoded by: hsa:2954
type: Species
is: SBO:0000252
initial concentration: NaN

metaM apoC Lys btn c
boundary condition: false
is: HMDB00182
type: Species
is: CHEBI:32551
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C16H27N4O3SX CHARGE: 0
has only substance units: false
constant: false
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110023#_34f93579_5be0_45e5_82f9_61ee911f5b65
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
name: MAN2B1
is encoded by: hsa:4125
is: O00754
has only substance units: false
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110023#_bf1b1362_19d0_4967_ac3d_77df2a224444
type: Species
boundary condition: true
is: SBO:0000252
is: B3KTV4
constant: false
initial concentration: NaN
name: ADSSL1
has only substance units: false
is encoded by: hsa:122622
initial amount: NaN

metaR CYTK5
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110023#
name: cytidylate kinase (dCMP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
product: MODEL1310110023#
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
reversible: true
fast: false
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110023#_ab26aaec_2ef5_4e3b_864f_43edaf05df40
has only substance units: false
name: KHK
constant: false
initial amount: NaN
is encoded by: hsa:3795
is: SBO:0000252
initial concentration: NaN
is: Q6IBK2
boundary condition: true
type: Species

metaR r1836
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
reversible: false
product: MODEL1310110023#
modifier: MODEL1310110023#
is: SBO:0000185
name: Y+LAT2 Utilized transport
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction

metaR LYSOXp
is described by: ECO:0000000
product: MODEL1310110023#
name: L-lysine oxidase, peroxisomal
reversible: false
type: Reaction
reactant: MODEL1310110023#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.4.3.14 Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957,PMID:6811962 NOTES:MM
kinetic law: MODEL1310110023#

metaM ksi pre32 g
notes: FORMULA: C227H362N16O192S10X CHARGE: -11
is: CHEBI:28067
type: Species
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 32
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0

metaR XOL7AH2tm
fast: false
product: MODEL1310110023#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reversible: true

metaR CYTK4
fast: false
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
reactant: MODEL1310110023#
name: cytidylate kinase (dCMP)(GTP)
reversible: true
product: MODEL1310110023#
kinetic law: MODEL1310110023#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.3

http://identifiers.org/biomodels.db/MODEL1310110023#_8cbde6ff_4714_4be3_92db_384343db3401
initial concentration: NaN
is: SBO:0000252
is: Q9Y6M9
has only substance units: false
type: Species
name: NDUFB9
initial amount: NaN
is encoded by: hsa:4715
boundary condition: true
constant: false

metaM dttp n
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB01342
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
initial concentration: 1.0
name: dTTP
is: C00459
constant: false
has only substance units: false
is: CHEBI:37568
boundary condition: false

metaR UGALNACtg
name: UDP-GalNAc Golgi transport via CMP antiport
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
fast: false
modifier: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000269
kinetic law: MODEL1310110023#
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110023#

metaM itp e
initial concentration: 1.0
is: CHEBI:57614
has only substance units: false
is: SBO:0000247
name: ITP(3-)
constant: false
initial amount: NaN
type: Species
is: HMDB00189
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
boundary condition: false

metaM ksi pre19 g
is: SBO:0000247
is: C00130
initial concentration: 1.0
notes: FORMULA: C171H275N12O137S5X CHARGE: -6
type: Species
is: CHEBI:58053
has only substance units: false
is: HMDB00175
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 19
constant: false
boundary condition: false

metaR ACNAMtn
type: Reaction
product: MODEL1310110023#
kinetic law: MODEL1310110023#
is: SBO:0000185
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: N-acetylneuraminate nuclear import
fast: false

metaM dha e
constant: false
has only substance units: false
is: HMDB01882
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
type: Species
name: glycerone
is: CHEBI:16016
initial amount: NaN

metaR GALASE12ly
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal
reversible: false
fast: false
type: Reaction
product: MODEL1310110023#
reactant: MODEL1310110023#
is described by: ECO:0000000

metaR 34HPPte
is described by: ECO:0000134
reversible: true
kinetic law: MODEL1310110023#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110023#
name: Transport of 3-(4-hydroxyphenyl)pyruvate
type: Reaction
reactant: MODEL1310110023#

metaR CYTK3
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
reactant: MODEL1310110023#
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
product: MODEL1310110023#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.3
reversible: true
name: cytidylate kinase (CMP)(GTP)
fast: false

metaR CYTK2
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
product: MODEL1310110023#
kinetic law: MODEL1310110023#
modifier: MODEL1310110023#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
is described by: ECO:0000269
name: cytidylate kinase (dCMP)
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110023#_a502bacf_34fb_4cfc_b08b_c8b218de7e51
initial amount: NaN
boundary condition: true
constant: false
type: Species
is encoded by: hsa:1103
name: CHAT
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: Q6LEN5

metaR EX ttdca LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecanoate (n-C14:0)
type: Reaction

metaM nm4masn g
has only substance units: false
type: Species
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
is: C05882
constant: false
is: SBO:0000247
notes: FORMULA: C54H90N3O40X CHARGE: 0
initial amount: NaN
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110023#_d0e7aada_9071_455e_bdf3_69476ac4c2b2
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
name: IDH2
is: P48735
is encoded by: hsa:3418
initial concentration: NaN

metaM pi m
is: HMDB00973
has only substance units: false
is: CHEBI:43474
initial amount: NaN
name: hydrogenphosphate
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: C00009
boundary condition: false
initial concentration: 1.0

metaM lnlncg l
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB03073
constant: false
type: Species
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
is: CHEBI:32391
has only substance units: false
name: gamma-linolenate

metaR CYTK1
kinetic law: MODEL1310110023#
name: cytidylate kinase (CMP)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
modifier: MODEL1310110023#
reversible: true
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
fast: false
product: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_db78fa11_49ad_44a4_985f_a5b96bc36f08
is: Q16851
boundary condition: true
is encoded by: hsa:7360
name: UGP2
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110023#_ac36efa3_5438_4bf9_955a_c81fec4137b0
is: SBO:0000252
boundary condition: true
is: P23921
constant: false
name: RRM1
type: Species
is encoded by: hsa:6240
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR r0539
is version of: http://identifiers.org/ec-code/1.1.1.34
kinetic law: MODEL1310110023#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:
modifier: MODEL1310110023#
fast: false
reactant: MODEL1310110023#
type: Reaction
product: MODEL1310110023#
reversible: true
is described by: ECO:0000000
name: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19

http://identifiers.org/biomodels.db/MODEL1310110023#_2451f2d3_ba40_4531_b027_3a4faf2d78cc
type: Species
initial amount: NaN
is encoded by: hsa:6533
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
name: SLC6A6
is: Q9BRI2

http://identifiers.org/biomodels.db/MODEL1310110023#_614bc257_0d69_4244_956c_ef5a6274a098
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:6580
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is: O15245
name: SLC22A1

metaR INSTt4 2
product: MODEL1310110023#
reversible: true
kinetic law: MODEL1310110023#
fast: false
is described by: ECO:0000006
modifier: MODEL1310110023#
name: inositol transport via sodium symport
reactant: MODEL1310110023#
type: Reaction
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110023#_20e3530f_ca1a_47e7_a10e_58dd88de3d85
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
name: _AI697028_1_e
type: Species
is encoded by: hsa:AI697028

metaR MM6bg
type: Reaction
kinetic law: MODEL1310110023#
reversible: false
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
reactant: MODEL1310110023#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.113
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
fast: false
product: MODEL1310110023#
modifier: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_a17ca731_11ed_4548_9d45_61ed1fba135c
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaR CYTK9
kinetic law: MODEL1310110023#
name: cytidylate kinase (CMP,dCTP)
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is: SBO:0000176
product: MODEL1310110023#
reactant: MODEL1310110023#

metaR EX met L LPAREN e RPAREN
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Methionine exchange
type: Reaction

metaR GLYCTO1p
type: Reaction
name: Glycolate oxidase, peroxisome
is: SBO:0000176
product: MODEL1310110023#
reactant: MODEL1310110023#
fast: false
reversible: false
kinetic law: MODEL1310110023#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.3.15
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (51179.1) or (54363.1) or (51179.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:tv NCD

metaR RE1903R
is described by: ECO:0000000
name: RE1903
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:
product: MODEL1310110023#
reactant: MODEL1310110023#
fast: false
reversible: true
kinetic law: MODEL1310110023#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110023#_20ee71e9_b6dd_4d4e_ba91_4b2964a1a8d0
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:115584
initial concentration: NaN
boundary condition: true
is: Q8WWX8
type: Species
name: SLC5A11

http://identifiers.org/biomodels.db/MODEL1310110023#_734f0d94_9d94_4cfb_a17f_cb6db1920e18
type: Species
name: NDUFV3
is: P56181
is encoded by: hsa:4731
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110023#_26a25ae2_c88b_46dd_9b98_8c72b82c1016
is: B3KXN9
name: ADO
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:84890

http://identifiers.org/biomodels.db/MODEL1310110023#_659f5a9a_26e1_4315_acb0_84d446137a79
has only substance units: false
initial amount: NaN
is encoded by: hsa:J03866
type: Species
name: _J03866_1_m
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN

metaM e4p c
is: C00279
name: D-Erythrose 4-phosphate
constant: false
is: CHEBI:16897
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB01321
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
type: Species

metaR CYTK8
reversible: true
kinetic law: MODEL1310110023#
reactant: MODEL1310110023#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110023#
fast: false
name: cytidylate kinase (CMP,dATP)
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_1fb02360_8049_41cc_9049_c1631fb01d7c
is: SBO:0000252
is: P48651
boundary condition: true
name: PTDSS1
has only substance units: false
is encoded by: hsa:9791
type: Species
initial amount: NaN
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110023#_768348cc_cff4_4717_9212_ac2eeea650d6
name: CYP27A1
is: Q02318
boundary condition: true
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1593
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110023#_553a5563_4dbb_4825_af16_e38907f64085
initial amount: NaN
has only substance units: false
is encoded by: hsa:9517
name: SPTLC1:SPTLC2
is encoded by: hsa:10558
constant: false
is: SBO:0000297
has part: O15270
type: Species
boundary condition: true
initial concentration: NaN
has part: O15269

metaR PPPG9tm
reactant: MODEL1310110023#
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:14623258 NOTES:NCD. Benzodiazepine receptor PBR see also 17168567
name: protoporphyrinogen IX mitochondrial transport
kinetic law: MODEL1310110023#
reversible: true
product: MODEL1310110023#

metaM phyt2ohcoa x
notes: FORMULA: C41H70N7O18P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O18P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)32(50)40(54)70-20-19-43-30(49)17-18-44-38(53)35(52)41(6,7)22-63-69(60,61)66-68(58,59)62-21-29-34(65-67(55,56)57)33(51)39(64-29)48-24-47-31-36(42)45-23-46-37(31)48/h23-29,32-35,39,50-52H,8-22H2,1-7H3,(H,43,49)(H,44,53)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/p-4/t26?,27?,28?,29-,32?,33-,34-,35+,39-/m1/s1 EHMN_ABBREVIATION: C07343
boundary condition: false
is: HMDB01295
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:57334
constant: false
initial amount: NaN
name: 2-hydroxyphytanoyl-CoA(4-)
is: SBO:0000247

metaR CYTK7
reactant: MODEL1310110023#
fast: false
reversible: true
modifier: MODEL1310110023#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110023#
kinetic law: MODEL1310110023#
name: cytidylate kinase (CMP,UTP)
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR AKGDm
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.61
reversible: false
reactant: MODEL1310110023#
type: Reaction
name: 2-oxoglutarate dehydrogenase
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (4967.2) and (1738.1 and 8050.1) and (1743.1) or (4967.1) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Citric acid cycle EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:1542694 NOTES:EC taken from Ligand TV. Genetic
kinetic law: MODEL1310110023#
is described by: ECO:0000134
product: MODEL1310110023#
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/1.2.4.2
fast: false

metaM lnlncg r
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
is: HMDB03073
initial concentration: 1.0
is: CHEBI:32391
is: SBO:0000247
has only substance units: false
constant: false
name: gamma-linolenate

metaR FRDPtr
kinetic law: MODEL1310110023#
reversible: true
product: MODEL1310110023#
name: lipid, flip-flop intracellular transport
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
fast: false
type: Reaction
reactant: MODEL1310110023#

http://identifiers.org/biomodels.db/MODEL1310110023#_41bb948e_fa8d_458c_b480_8370fa94e95f
type: Species
constant: false
boundary condition: true
is: F5H6D0
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: MOGS
has only substance units: false
is encoded by: hsa:7841

metaM xol25oh r
name: 25-hydroxycholesterol
constant: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01146
type: Species
is: SBO:0000247
is: HMDB06247
initial amount: NaN
boundary condition: false
is: CHEBI:42977
has only substance units: false
initial concentration: 1.0

metaR CYTK6
fast: false
name: cytidylate kinase (CMP,CTP)
product: MODEL1310110023#
reactant: MODEL1310110023#
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110023#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110023#