metaM ctp e
is: HMDB00082
initial concentration: 1.0
initial amount: NaN
name: CTP(4-)
constant: false
has only substance units: false
type: Species
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: CHEBI:37563
boundary condition: false
is: SBO:0000247

metaR r1589
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110022#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110022#
product: MODEL1310110022#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110022#_f4f8668f_523b_49f1_8924_02e8210ecbfe
is: SBO:0000252
constant: false
type: Species
boundary condition: true
has only substance units: false
name: SDHA
initial concentration: NaN
is encoded by: hsa:6389
is: P31040
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_dc8547e3_062e_49e8_87eb_fb0af0011578
boundary condition: true
is: F8WDN9
is encoded by: hsa:27068
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
name: PPA2

http://identifiers.org/biomodels.db/MODEL1310110022#_9764276c_d692_4589_80bb_e01788354dc4
constant: false
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:80025
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: PANK2
is: Q6P1K9

http://identifiers.org/biomodels.db/MODEL1310110022#_195f6faf_3463_46c2_9ee5_d8d0fa048163
is: Q6I9V5
has only substance units: false
is encoded by: hsa:293
name: SLC25A6
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN

metaR HPYRDC
reactant: MODEL1310110022#
name: hydroxypyruvate decarboxylase
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 4.1.1.40 Confidence Level: 2 AUTHORS: PMID:3778681 NOTES:NCD
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110022#
type: Reaction
is: SBO:0000176
product: MODEL1310110022#

metaM HC01602 c
is: HMDB02704
is: SBO:0000247
name: 10-formyltetrahydrofolate-[Glu](5)
initial concentration: 1.0
notes: FORMULA: C40H45N11O19 CHARGE: -6
constant: false
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:21338

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

metaM hpyr c
constant: false
initial concentration: 1.0
type: Species
name: 3-hydroxypyruvate
is: SBO:0000247
has only substance units: false
notes: FORMULA: C3H3O4 CHARGE: -1 INCHI: InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00163 EHMN_ABBREVIATION: C00168
is: HMDB01352
is: CHEBI:17180
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110022#_882c20d6_8805_4066_9cc1_0de89ce423a0
type: Species
constant: false
has part: Q86U05
is encoded by: hsa:23428
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000297
name: SLC7A8:SLC3A2
initial concentration: NaN

metaR DNDPt26m
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110022#
reversible: false
fast: false
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
name: dCDP transport via dUDP antiport
product: MODEL1310110022#

metaR 3MOX4HOXPGALDOX
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
reversible: false
is: SBO:0000176
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NAD+ oxidoreductase
product: MODEL1310110022#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
modifier: MODEL1310110022#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110022#_3c9d2ee3_7edb_4cd6_8339_55b7c6bd4b23
is encoded by: hsa:4731
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: P56181
constant: false
name: NDUFV3
type: Species
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110022#_43112157_fb7a_4c44_ac17_bcd70e73cfef
constant: false
name: _AA081045_1_c
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AA081045

http://identifiers.org/biomodels.db/MODEL1310110022#_b1f20da6_d1e2_4ccd_be88_cca8245cfd81
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
name: _AU149534_1_e
is encoded by: hsa:AU149534

metaR r1588
reversible: true
kinetic law: MODEL1310110022#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110022#

metaR ASCBt
name: L-ascorbate transport via facilitated diffusion
type: Reaction
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000185
product: MODEL1310110022#
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD

metaR r1610
type: Reaction
reversible: true
kinetic law: MODEL1310110022#
fast: false
product: MODEL1310110022#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110022#

metaR MACACI
is version of: http://identifiers.org/ec-code/2.5.1.18
modifier: MODEL1310110022#
product: MODEL1310110022#
name: maleylacetoacetate isomerase
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (2954.1) or (2954.3) or (2954.2) SUBSYSTEM: Tyrosine metabolism EC Number: 5.2.1.2 Confidence Level: 4 AUTHORS: PMID:10373324 NOTES:NCD
kinetic law: MODEL1310110022#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110022#_22389562_5dfe_4b18_9269_9b1efd6e824b
constant: false
name: XDH
initial concentration: NaN
is encoded by: hsa:7498
initial amount: NaN
is: SBO:0000252
is: P47989
has only substance units: false
boundary condition: true
type: Species

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_da829e50_56af_46d1_9347_47678ea4193a
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: P19801
initial concentration: NaN
type: Species
is encoded by: hsa:26
constant: false
name: ABP1

metaM ps hs c
constant: false
is: CHEBI:18303
initial amount: NaN
is: SBO:0000247
name: ps_hs[c]
has only substance units: false
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
type: Species
initial concentration: 1.0
boundary condition: false

metaM ahcys r
boundary condition: false
is: SBO:0000247
notes: FORMULA: C14H20N6O5S CHARGE: 0 INCHI: InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
name: S-adenosyl-L-homocysteine
has only substance units: false
is: CHEBI:16680
is: HMDB00939

http://identifiers.org/biomodels.db/MODEL1310110022#_ba1d62ea_8cad_4082_918b_4bf2c2641f26
boundary condition: true
is encoded by: hsa:204
constant: false
initial concentration: NaN
is: P54819
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
name: AK2

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

metaM itp n
is: HMDB00189
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
has only substance units: false
type: Species
is: CHEBI:57614
initial concentration: 1.0
boundary condition: false
name: ITP(3-)
is: SBO:0000247
initial amount: NaN
constant: false

metaR SERt4
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:JLR
name: L-serine via sodium symport
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
reversible: false
product: MODEL1310110022#
is: SBO:0000185
reactant: MODEL1310110022#
fast: false

metaR r0236
is: SBO:0000176
reactant: MODEL1310110022#
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
type: Reaction
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.5.1.6
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
is described by: ECO:0000000
reversible: true

metaR r1587
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110022#
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185
reactant: MODEL1310110022#
product: MODEL1310110022#

metaM cyan c
is: HMDB02084
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
constant: false
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
name: hydrogen cyanide
is: CHEBI:18407

http://identifiers.org/biomodels.db/MODEL1310110022#_a18ae7a3_41ff_4e77_a206_896e24f2147d
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000252
name: _7359_1_c
is encoded by: hsa:7359
boundary condition: true
initial concentration: NaN

metaM pail4p hs c
is: CHEBI:58178
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277

http://identifiers.org/biomodels.db/MODEL1310110022#_49125a0a_18d3_4e42_8b7f_47afce96e169
is: Q9NPB1
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:56953
name: NT5M
initial concentration: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_bdbf763c_f876_44ff_8bda_395c00a50b1c
boundary condition: true
has only substance units: false
is encoded by: hsa:286016
initial concentration: NaN
constant: false
name: TPI1P2
initial amount: NaN
is: SBO:0000252
type: Species

metaM acetone m
initial amount: NaN
initial concentration: 1.0
is: HMDB01659
name: acetone
constant: false
is: CHEBI:15347
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false

metaM ksi deg32 l
type: Species
boundary condition: false
name: keratan sulfate I, degradation product 32
initial concentration: 1.0
notes: FORMULA: C82H135N5O67S2 CHARGE: -2
is: HMDB00143
is: SBO:0000247
constant: false
is: CHEBI:12936
has only substance units: false
initial amount: NaN

metaR 34HPPOR
fast: false
reactant: MODEL1310110022#
is: SBO:0000176
name: 4-Hydroxyphenylpyruvate:oxygen oxidoreductase
reversible: false
product: MODEL1310110022#
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.13.11.27
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3242.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.27 Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110022#

metaR r1692
type: Reaction
is: SBO:0000185
modifier: MODEL1310110022#
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reversible: false
fast: false
reactant: MODEL1310110022#
is described by: ECO:0000000
kinetic law: MODEL1310110022#

metaR MDHm
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
modifier: MODEL1310110022#
name: malate dehydrogenase, mitochondrial
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.37
reversible: true
is described by: ECO:0000134
is: SBO:0000176
product: MODEL1310110022#

metaM gua e
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
is: HMDB00132
name: guanine
is: CHEBI:16235

http://identifiers.org/biomodels.db/MODEL1310110022#_13a6515f_2a36_4a29_91a8_83786404b9c5
is: O75355
has only substance units: false
type: Species
is: SBO:0000252
name: ENTPD3
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:956

metaR r2139
is described by: ECO:0000000
modifier: MODEL1310110022#
reversible: true
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110022#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110022#
type: Reaction
kinetic law: MODEL1310110022#

metaR PAIL4P HStn
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
product: MODEL1310110022#
is described by: ECO:0000000
kinetic law: MODEL1310110022#
fast: false
reversible: true
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)
type: Reaction
reactant: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_09dfafa5_e7be_46ff_8177_5a80814f3910
initial concentration: NaN
has only substance units: false
name: GALNT5
is encoded by: hsa:11227
constant: false
initial amount: NaN
is: A5PKZ1
boundary condition: true
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110022#_6e610b70_c0d7_487a_852e_69240e9f2d86
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: Q53TV9
has only substance units: false
name: RPE
type: Species
constant: false
is encoded by: hsa:6120
initial concentration: NaN

metaR FK
reversible: false
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (197258.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.52 Confidence Level: 0 AUTHORS: NOTES:kh 1/6/03 NCD
is described by: ECO:0000000
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.7.1.52
product: MODEL1310110022#
is: SBO:0000176
type: Reaction
name: Fucokinase
fast: false

metaR PYRt2m
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD
type: Reaction
reversible: true
is described by: ECO:0000000
name: pyruvate mitochondrial transport via proton symport

metaM amet r
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C15H23N6O5S CHARGE: 1 INCHI: InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/p+1/t7-,8+,10+,11+,14+,27?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
type: Species
is: SBO:0000247
name: S-adenosyl-L-methionine
is: CHEBI:15414
is: HMDB01185
has only substance units: false

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_08c5587d_e9e2_40bb_8b83_50aa0a4445b6
name: SUOX
is encoded by: hsa:6821
is: SBO:0000252
is: P51687
constant: false
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_ac415391_0186_47d6_9a62_3c0913c66dca
boundary condition: true
is: SBO:0000252
type: Species
name: ALPP
is: P05187
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:250
has only substance units: false

metaR NODe
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110022#
type: Reaction
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: NODe
reactant: MODEL1310110022#
fast: false
is described by: ECO:0000134

metaR r1586
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110022#
product: MODEL1310110022#
kinetic law: MODEL1310110022#
reversible: true
is described by: ECO:0000000
is: SBO:0000185

metaM tdchola e
type: Species
is: HMDB00951
constant: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: taurochenodeoxycholate
has only substance units: false
boundary condition: false
is: CHEBI:9407

http://identifiers.org/biomodels.db/MODEL1310110022#_8fa11a8d_980c_4def_8a10_182ccbba209a
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1807
has only substance units: false
name: DPYS
is: Q14117
type: Species
constant: false
boundary condition: true

metaR RE1709C
name: RE1709
reversible: true
reactant: MODEL1310110022#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110022#
kinetic law: MODEL1310110022#

metaR r1613
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110022#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110022#
kinetic law: MODEL1310110022#
is: SBO:0000185
reactant: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_aa728031_2a39_4608_975e_6994614c1518
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AI285872
name: _AI285872_1_c
has only substance units: false
type: Species
is: SBO:0000252
constant: false
boundary condition: true

metaM xyl D l
type: Species
constant: false
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: aldehydo-D-xylose
is: CHEBI:15936

metaM gua c
is: HMDB00132
has only substance units: false
name: Guanine
is: CHEBI:16235
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
type: Species
is: C00242
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110022#_265d13f0_2a01_48f1_b100_b97f80d167db
is encoded by: hsa:55568
initial concentration: NaN
type: Species
initial amount: NaN
name: GALNT10
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252

metaR r2136
is: SBO:0000185
product: MODEL1310110022#
reactant: MODEL1310110022#
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
reversible: false
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
modifier: MODEL1310110022#
type: Reaction
is described by: ECO:0000000
fast: false

metaR r0354
modifier: MODEL1310110022#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
fast: false
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110022#
product: MODEL1310110022#
kinetic law: MODEL1310110022#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110022#_c9a13148_c504_45bd_9ec6_862bbbd8b22c
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:U37519
has only substance units: false
boundary condition: true
name: _U37519_1_c

http://identifiers.org/biomodels.db/MODEL1310110022#_4f2f1bb6_daa7_4a86_a805_9ebf54211c8b
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AI824319
name: _AI824319_1_r
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_edb2b0ce_b4bf_4ce9_8c3d_98f42691108b
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6647
is: P00441
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
type: Species
name: SOD1

metaR PYRt2r
reactant: MODEL1310110022#
name: pyruvate reversible transport via proton symport
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
product: MODEL1310110022#
is described by: ECO:0000269
fast: false
type: Reaction
kinetic law: MODEL1310110022#
is: SBO:0000185
modifier: MODEL1310110022#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110022#_69b8c0c9_0067_47fc_994d_064c96f8b1ca
is encoded by: hsa:226
has only substance units: false
boundary condition: true
is: P04075
constant: false
name: ALDOA
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN

metaM HC02203 e
is: CHEBI:27820
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
has only substance units: false
constant: false
name: prostaglandin-a2
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species

metaM pglyc hs c
boundary condition: false
is: SBO:0000247
is: HMDB02704
type: Species
constant: false
initial amount: NaN
has only substance units: false
name: pglyc_hs[c]
is: CHEBI:21338
notes: FORMULA: CHARGE: 0
initial concentration: 1.0

metaR UDPGLCter
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110022#
product: MODEL1310110022#
type: Reaction
fast: false
reactant: MODEL1310110022#
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110022#_9761ea0b_8125_4b59_acc7_4a9c22698af6
type: Species
is encoded by: hsa:376497
has only substance units: false
initial concentration: NaN
is: Q6PCB7
constant: false
name: SLC27A1
initial amount: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110022#_66986b1f_2510_4ed4_98a0_2ff3e255ea36
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:51809
type: Species
is: Q86SF2
is: SBO:0000252
constant: false
name: GALNT7

metaR UDPDOLPT L
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.117
modifier: MODEL1310110022#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:8280060 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
type: Reaction
product: MODEL1310110022#
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (liver)

metaR r1614
kinetic law: MODEL1310110022#
is: SBO:0000185
modifier: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110022#
type: Reaction

metaR r2137
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
reversible: true
modifier: MODEL1310110022#
fast: false
product: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110022#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.14.6

metaR r0355
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.3
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110022#
fast: false
product: MODEL1310110022#
reversible: false
name: Glycolysis / Glyconeogenesis EC:2.7.1.1

metaR CYOOm3
is version of: http://identifiers.org/ec-code/1.9.3.1
kinetic law: MODEL1310110022#
name: cytochrome c oxidase, mitochondrial Complex IV
fast: false
product: MODEL1310110022#
reversible: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000134
modifier: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

metaM tdchola c
initial concentration: 1.0
name: taurochenodeoxycholate
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
is: CHEBI:9407
is: HMDB00951

http://identifiers.org/biomodels.db/MODEL1310110022#_174715d1_4742_46d7_ac7d_e45b8645a4e2
boundary condition: true
initial concentration: NaN
constant: false
is: O00624
is encoded by: hsa:10246
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: SLC17A2
type: Species

metaM etoh c
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
initial concentration: 1.0
name: ethanol
is: HMDB00108
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:16236

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

metaR DGSNt
reversible: true
kinetic law: MODEL1310110022#
name: deoyguanosine transport via diffusion
is: SBO:0000185
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
type: Reaction
fast: false
reactant: MODEL1310110022#
is described by: ECO:0000000

metaM bildglcur c
is: HMDB03325
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
is: CHEBI:58471
initial amount: NaN
name: bis(beta-glucosyluronate)bilirubin
is: SBO:0000247
has only substance units: false

metaM amp c
constant: false
is: HMDB00045
name: AMP
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C10H12N5O7P CHARGE: -2
has only substance units: false
is: C00020
initial amount: NaN
initial concentration: 1.0
is: CHEBI:3322

metaM dcmp n
boundary condition: false
has only substance units: false
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
is: CHEBI:57566
is: HMDB01202
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
name: dCMP(2-)
is: SBO:0000247

metaR LEUKTRD4tr
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000185
type: Reaction
name: leukotriene intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110022#

metaM amp e
is: SBO:0000247
is: HMDB00045
type: Species
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
name: AMP
boundary condition: false
is: C00020
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:456215

metaM trp L c
boundary condition: false
is: HMDB00929
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
name: L-tryptophan
is: CHEBI:16828
type: Species
initial concentration: 1.0

metaR EX xyl D LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Xylose exchange
type: Reaction

metaR r1611
kinetic law: MODEL1310110022#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
product: MODEL1310110022#
reactant: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110022#_5b811841_eae3_4645_8ac5_3882a62b1c85
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
name: SQLE
is encoded by: hsa:6713
boundary condition: true
type: Species
is: Q5HYI4
has only substance units: false

metaR RE2269E
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
type: Reaction
name: RE2269
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.4.21.39
product: MODEL1310110022#
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#

metaM udpacgal c
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
constant: false
has only substance units: false
name: UDP-N-acetyl-D-galactosamine(2-)
type: Species
boundary condition: false
is: CHEBI:57847
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB00304

http://identifiers.org/biomodels.db/MODEL1310110022#_a1f05dd2_24ae_4f8e_b5a1_762fb73d868b
is: SBO:0000252
initial concentration: NaN
name: IDI1
boundary condition: true
constant: false
type: Species
is: Q13907
initial amount: NaN
has only substance units: false
is encoded by: hsa:3422

metaM HC02203 c
boundary condition: false
initial amount: NaN
constant: false
type: Species
has only substance units: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
initial concentration: 1.0
is: CHEBI:27820
name: prostaglandin-a2
is: SBO:0000247

metaM xol25oh r
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
is: CHEBI:42977
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01146
boundary condition: false
is: SBO:0000247
name: 25-hydroxycholesterol
is: HMDB06247

metaM malthx e
is: SBO:0000247
has only substance units: false
name: Maltohexaose
type: Species
constant: false
initial amount: NaN
is: C01936
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5041
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
boundary condition: false

metaM glutcoa m
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
constant: false
name: glutaryl-CoA(5-)
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
initial amount: NaN
is: HMDB01339
initial concentration: 1.0
is: CHEBI:57378

metaR r1612
modifier: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
product: MODEL1310110022#
is described by: ECO:0000000
reactant: MODEL1310110022#

metaM 7dhf e
has only substance units: false
name: heptaglutamyl folate (DHF)
type: Species
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
is: SBO:0000247
initial concentration: 1.0
is: HMDB06559
constant: false
initial amount: NaN
boundary condition: false

metaM HC02204 c
name: prostaglandin-b1
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:27624

http://identifiers.org/biomodels.db/MODEL1310110022#_1daff7a5_f8b8_4b06_b7c7_6513bc07c42e
initial concentration: NaN
name: RDH5
initial amount: NaN
has only substance units: false
is: Q92781
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:5959
constant: false

metaM q10h2 m
boundary condition: false
name: Ubiquinol-10
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
initial amount: NaN
is: http://identifiers.org/pubchem.compound/6504740
is: HMDB13111
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false

metaM etoh e
constant: false
is: HMDB00108
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
name: ethanol
type: Species
is: CHEBI:16236
initial amount: NaN
boundary condition: false

metaM bildglcur e
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB03325
name: bis(beta-glucosyluronate)bilirubin
has only substance units: false
type: Species
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
constant: false
is: CHEBI:58471

http://identifiers.org/biomodels.db/MODEL1310110022#_b65fca86_168a_4a97_9aa9_3781810b7e37
constant: false
name: TKTL2
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: Q9H0I9
is encoded by: hsa:84076

http://identifiers.org/biomodels.db/MODEL1310110022#_3cd6fcf4_0ca0_40a1_954c_8a584a1b9050
constant: false
is encoded by: hsa:126328
boundary condition: true
name: NDUFA11
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: C9JT23
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_26f1b8eb_c1ea_44fb_83a2_ed560b793f17
type: Species
constant: false
is: O14880
has only substance units: false
is encoded by: hsa:4259
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: MGST3
initial concentration: NaN

metaM 3hmbcoa m
initial amount: NaN
boundary condition: false
is: HMDB01356
is: CHEBI:57312
has only substance units: false
is: SBO:0000247
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
constant: false
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_035f70b3_a6fb_417f_8a88_d3d121752bdd
name: OGDH
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
is: Q02218
is encoded by: hsa:4967
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_d4b4c2b2_353f_4373_af31_199bc3424a35
initial amount: NaN
has only substance units: false
is: P00491
boundary condition: true
initial concentration: NaN
constant: false
name: PNP
is: SBO:0000252
is encoded by: hsa:4860
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_7f96610b_c6df_4cc7_ba55_7495ead7f5d2
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: _AI971036_1_m
type: Species
is encoded by: hsa:AI971036
has only substance units: false
constant: false
boundary condition: true

metaM ctp n
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
name: CTP(4-)
type: Species
is: HMDB00082
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:37563
constant: false

metaR GALASE9ly
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110022#
name: beta-galactosidase, lysosomal
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
product: MODEL1310110022#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18

metaR r1581
kinetic law: MODEL1310110022#
is described by: ECO:0000000
reactant: MODEL1310110022#
fast: false
reversible: true
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR DNDPt30m
modifier: MODEL1310110022#
product: MODEL1310110022#
fast: false
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110022#
is described by: ECO:0000269
is: SBO:0000185
reversible: false
name: dCDP transport via ADP antiport
type: Reaction

metaR ADK1
name: adenylate kinase
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.3
type: Reaction
modifier: MODEL1310110022#
product: MODEL1310110022#
reversible: true
kinetic law: MODEL1310110022#
is described by: ECO:0000269
reactant: MODEL1310110022#
fast: false

metaM maltpt e
constant: false
is: HMDB01296
type: Species
is: C02052
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5141
name: maltopentaose
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835

metaM dttp n
has only substance units: false
initial amount: NaN
name: dTTP
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
is: C00459
constant: false
is: HMDB01342
is: CHEBI:37568
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459

metaM trp L e
type: Species
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
initial concentration: 1.0
is: SBO:0000247
is: HMDB00929
name: L-tryptophan
has only substance units: false
initial amount: NaN
is: CHEBI:16828
constant: false
boundary condition: false

metaM ksi deg39 l
is: HMDB00143
initial amount: NaN
is: CHEBI:12936
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 39
notes: FORMULA: C48H81N3O36 CHARGE: 0
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110022#_5ab27139_e09e_4293_a8d5_fd4ee2cf313a
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:M68895
has only substance units: false
name: _M68895_1_c
is: SBO:0000252
boundary condition: true
type: Species
constant: false

metaM hs deg17 l
is: CHEBI:21338
constant: false
notes: FORMULA: C43H65N2O48S4 CHARGE: -5
initial concentration: 1.0
type: Species
is: HMDB02704
has only substance units: false
boundary condition: false
name: heparan sulfate, degradation product 17
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110022#_35393c19_4a06_4516_a6b3_fc7d9c79779e
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6392
initial amount: NaN
constant: false
has only substance units: false
is: O14521
is: SBO:0000252
type: Species
name: SDHD

metaR r1617
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110022#
reversible: true
reactant: MODEL1310110022#
product: MODEL1310110022#
is: SBO:0000185
is described by: ECO:0000000
fast: false

metaR r0926
is: SBO:0000185
kinetic law: MODEL1310110022#
product: MODEL1310110022#
name: Postulated transport reaction
type: Reaction
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110022#_282ec0f9_1512_4b79_9994_cceed6d18bfa
initial concentration: NaN
is encoded by: hsa:1327
initial amount: NaN
constant: false
name: COX4I1
is: P13073
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true

metaM ala D c
has only substance units: false
constant: false
name: D-alanine
initial amount: NaN
is: SBO:0000247
is: HMDB01310
is: CHEBI:15570
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
type: Species
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110022#_0fde41d7_ce78_48d9_86c9_43508441a6a6
constant: false
type: Species
boundary condition: true
name: OCRL
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4952

metaR UDPGALtg
fast: false
reactant: MODEL1310110022#
name: UDP-Gal Golgi transport via CMP antiport
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
product: MODEL1310110022#
reversible: true
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD

metaM asn L e
constant: false
initial concentration: 1.0
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
is: HMDB00168
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:17196
type: Species
name: L-asparagine
initial amount: NaN

metaR r2079
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110022#
product: MODEL1310110022#
kinetic law: MODEL1310110022#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
modifier: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction

metaR r0464
is: SBO:0000176
reversible: true
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110022#
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
kinetic law: MODEL1310110022#

metaR L LACt2r
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
modifier: MODEL1310110022#
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
fast: false
name: L-lactate reversible transport via proton symport
reversible: true
is described by: ECO:0000269
type: Reaction
is: SBO:0000185

metaR r1580
product: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110022#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110022#_c1998d35_79c7_4f76_80a2_fff857a172d2
is encoded by: hsa:2805
boundary condition: true
initial amount: NaN
type: Species
name: GOT1
is: P17174
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false

metaM dhcholestancoa x
constant: false
is: SBO:0000247
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
type: Species
boundary condition: false
initial amount: NaN
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
is: HMDB02159
initial concentration: 1.0
is: CHEBI:15494
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_af34a2d2_4c77_45e1_a4dd_e29ae126fac6
boundary condition: true
is encoded by: hsa:4729
constant: false
is: SBO:0000252
type: Species
name: NDUFV2
initial concentration: NaN
has only substance units: false
is: P19404
initial amount: NaN

metaM HC02204 e
initial concentration: 1.0
name: prostaglandin-b1
is: CHEBI:27624
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
initial amount: NaN
has only substance units: false
constant: false
type: Species

metaR r1728
type: Reaction
product: MODEL1310110022#
reactant: MODEL1310110022#
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110022#
reversible: false
fast: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110022#_b77fa95a_706d_46b6_aeed_c3e8f966ae54
name: PCBD1
is: P61457
is encoded by: hsa:5092
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false

metaR r1618
reactant: MODEL1310110022#
product: MODEL1310110022#
is: SBO:0000185
fast: false
modifier: MODEL1310110022#
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

metaM hs deg10 l
name: heparan sulfate, degradation product 10
notes: FORMULA: C55H80N3O70S8 CHARGE: -9
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:15748
boundary condition: false
constant: false
is: HMDB00127
initial amount: NaN

metaM ksi deg29 l
is: CHEBI:12936
is: SBO:0000247
notes: FORMULA: C96H157N6O80S3 CHARGE: -3
is: HMDB00143
name: keratan sulfate I, degradation product 29
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110022#_a1a80b10_80fb_4aff_85e2_33867a0e9fd6
is encoded by: hsa:7390
boundary condition: true
initial concentration: NaN
name: UROS
has only substance units: false
is: SBO:0000252
is: P10746
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_b20add35_6313_46ab_adab_423b664b434a
is encoded by: hsa:8527
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
name: DGKD
initial concentration: NaN
is: Q16760
has only substance units: false
boundary condition: true

metaR DGCHOLte
kinetic law: MODEL1310110022#
fast: false
name: bile acid intracellular transport
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
product: MODEL1310110022#
is described by: ECO:0000000
reactant: MODEL1310110022#
type: Reaction

metaM dcmp c
constant: false
name: dCMP
is: C00239
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:57566
initial amount: NaN
is: SBO:0000247
is: HMDB01202
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
boundary condition: false

metaR r1615
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
modifier: MODEL1310110022#
fast: false
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_3898b69e_ef17_43c0_a0ba_321d5a25a727
is encoded by: hsa:2747
name: GLUD2
has only substance units: false
initial concentration: NaN
is: P49448
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
boundary condition: true

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

metaM gluside hs c
name: D-glucosyl-N-acylsphingosine
has only substance units: false
is: CHEBI:18368
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN

metaR LTD4DP
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
product: MODEL1310110022#
name: Leukotriene D4 dipeptidase

http://identifiers.org/biomodels.db/MODEL1310110022#_8f656c26_1aba_4e16_806b_84881daaeaee
type: Species
has only substance units: false
name: SLCO1B1
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10599
boundary condition: true
constant: false
initial concentration: NaN
is: Q9Y6L6

metaM pectingchol e
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C2561H3553NO2541 CHARGE: 0
constant: false
initial concentration: 1.0
boundary condition: false
name: pectin-glycocholate complex
type: Species
has only substance units: false
is: HMDB03402

http://identifiers.org/biomodels.db/MODEL1310110022#_058c51b7_f422_4b56_a6ce_d7a437d0baed
is encoded by: hsa:3036
constant: false
initial amount: NaN
is: Q8IYH3
type: Species
is: SBO:0000252
boundary condition: true
name: HAS1
has only substance units: false
initial concentration: NaN

metaR RE2814R
type: Reaction
product: MODEL1310110022#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
name: RE2814
kinetic law: MODEL1310110022#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110022#_f6ff1661_1511_4738_a6a0_d04f5ed43895
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: ADSSL1
type: Species
is encoded by: hsa:122622
has only substance units: false
is: Q8N142

metaR FRDPtr
type: Reaction
name: lipid, flip-flop intracellular transport
fast: false
reactant: MODEL1310110022#
reversible: true
kinetic law: MODEL1310110022#
product: MODEL1310110022#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ

metaM asn L c
name: L-asparagine
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:17196
is: HMDB00168
is: SBO:0000247

metaM acgam6p c
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
type: Species
name: N-acetyl-D-glucosamine 6-phosphate(2-)
is: CHEBI:57513
initial amount: NaN
is: HMDB01062

http://identifiers.org/biomodels.db/MODEL1310110022#_3fc8d71b_05eb_48b7_a896_a4bbf75a2ba0
initial amount: NaN
is encoded by: hsa:2678
type: Species
constant: false
boundary condition: true
name: GGT1
is: P19440
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR PDHm
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.2.4.1
reversible: false
notes: GENE_ASSOCIATION: (1738.1 and 8050.1) and (5161.1 and 5162.1) and (1737.1) or (1738.1 and 8050.1) and (5160.1 and 5162.1) and (1737.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.3.1.12 Confidence Level: 0 AUTHORS: PMID:12372595,PMID:16436377 NOTES:12372595 - expression; 16436377 - biochemical, tissue-specific
name: pyruvate dehydrogenase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.4
is described by: ECO:0000134
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.12
modifier: MODEL1310110022#
fast: false

metaR RE0944E
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.1
name: RE0944
fast: false
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.17
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
is described by: ECO:0000000
product: MODEL1310110022#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110022#_e4757e12_63a8_41be_b567_4da57d9d0dee
type: Species
is: Q9UI40
boundary condition: true
name: SLC24A2
initial amount: NaN
has only substance units: false
is encoded by: hsa:25769
initial concentration: NaN
is: SBO:0000252
constant: false

metaM dgdp m
name: dGDP(2-)
type: Species
initial amount: NaN
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:58595
is: HMDB00960
boundary condition: false
is: SBO:0000247

metaM amp r
boundary condition: false
is: SBO:0000247
constant: false
name: AMP
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: CHEBI:456215
is: C00020
is: HMDB00045
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110022#_942086c7_fb7a_4957_89ba_6656a417dff0
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:27068
name: PPA2
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true

metaR SPH1Pte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
name: sph1p transport
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110022#
reactant: MODEL1310110022#
type: Reaction
kinetic law: MODEL1310110022#
is: SBO:0000185

metaM dolp L r
name: dolichyl phosphate(2-)
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
is: SBO:0000247
constant: false
is: CHEBI:57683
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false

metaR r1616
type: Reaction
modifier: MODEL1310110022#
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM dcholcoa c
is: CHEBI:28701
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
boundary condition: false
name: chenodeoxycholoyl coenzyme a
is: SBO:0000247
has only substance units: false
is: HMDB06292

metaM maltttr e
is: HMDB01296
initial concentration: 1.0
type: Species
name: Maltotetraose
is: SBO:0000247
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/5141
initial amount: NaN
is: C02052
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_818b215a_d37c_45f8_93c5_aa847618348c
name: RPIA
is: SBO:0000252
type: Species
initial amount: NaN
is: P49247
boundary condition: true
is encoded by: hsa:22934
has only substance units: false
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_d7248c75_5a81_451e_88b2_7d5072ba99e7
name: SUCLA2
is: SBO:0000252
has only substance units: false
type: Species
is: E5KS60
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:8803
constant: false

metaM ksi deg18 l
constant: false
is: SBO:0000247
notes: FORMULA: C146H235N10O127S7 CHARGE: -7
initial amount: NaN
is: HMDB00143
boundary condition: false
has only substance units: false
is: CHEBI:12936
initial concentration: 1.0
type: Species
name: keratan sulfate I, degradation product 18

metaR DURAD
type: Reaction
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.3.1.2
fast: false
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
name: dihydrouracil dehydrogenase (NADP)
reactant: MODEL1310110022#
is described by: ECO:0000269
modifier: MODEL1310110022#
product: MODEL1310110022#

metaR r1585
reversible: true
product: MODEL1310110022#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

metaM f6p c
initial concentration: 1.0
constant: false
is: CHEBI:57579
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB00124
is: C00085
boundary condition: false
is: http://identifiers.org/pubchem.compound/3385
type: Species
name: D-Fructose 6-phosphate

metaR EX ncam LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinamide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_5e2aa70e_8fe0_4d3f_b145_4bda87a724e8
has only substance units: false
constant: false
is: Q8NEM3
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
name: SLC16A7
is encoded by: hsa:9194
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_bed29a59_92d8_4bc3_867e_1852fe9ac67b
is: SBO:0000252
boundary condition: true
name: GSTZ1
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:2954
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_332ab90c_678b_4ca8_aa21_969c7632b0a4
has only substance units: false
constant: false
type: Species
is encoded by: hsa:AF080579
name: _AF080579_1_c
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110022#_a6893b70_2172_497c_a4e3_ff76f772ecc9
initial concentration: NaN
is: SBO:0000252
name: _H17063_1_m
is encoded by: hsa:H17063
has only substance units: false
type: Species
constant: false
boundary condition: true
initial amount: NaN

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

metaM ksi deg11 l
is: HMDB00143
boundary condition: false
notes: FORMULA: C180H289N12O158S9 CHARGE: -9
has only substance units: false
initial amount: NaN
constant: false
name: keratan sulfate I, degradation product 11
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:12936

http://identifiers.org/biomodels.db/MODEL1310110022#_65662411_ad7d_4966_b8fc_93b0ef44049d
is encoded by: hsa:686
boundary condition: true
constant: false
name: BTD
has only substance units: false
initial concentration: NaN
is: P43251
is: SBO:0000252
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_991dda0a_f9cf_4218_b3d6_3e197a4dc0c7
boundary condition: true
constant: false
is encoded by: hsa:5315
name: PKM2
is: P14618
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false

metaR r0129
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
modifier: MODEL1310110022#
product: MODEL1310110022#
is: SBO:0000176
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
is version of: http://identifiers.org/ec-code/2.7.1.40

metaM sucsal m
constant: false
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
type: Species
boundary condition: false
is: CHEBI:57706
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01259
name: Succinic semialdehyde

metaM dgdp n
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
initial amount: NaN
is: HMDB00960
name: dGDP(2-)
is: CHEBI:58595
constant: false
initial concentration: 1.0
boundary condition: false

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_376687bc_d88d_4b49_8900_f484949e30f6
has only substance units: false
is encoded by: hsa:80864
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: EGFL8
is: Q99944
constant: false

metaR r1584
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110022#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110022#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110022#

metaM biocyt c
initial amount: NaN
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
initial concentration: 1.0
has only substance units: false
is: C05552
boundary condition: false
is: SBO:0000247
is: HMDB03134
type: Species
constant: false
is: http://identifiers.org/pubchem.compound/7886
name: Biocytin

metaR FCLTm
is version of: http://identifiers.org/ec-code/4.99.1.1
is: SBO:0000176
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (2235.1) or (2235.2) SUBSYSTEM: Heme synthesis EC Number: 4.99.1.1 Confidence Level: 2 AUTHORS: PMID:7983009 NOTES:NCD; r0096
modifier: MODEL1310110022#
product: MODEL1310110022#
is described by: ECO:0000304
name: Ferrochelatase, mitochondrial
reactant: MODEL1310110022#
type: Reaction
fast: false
reversible: false

metaR NAHCO3 HCLt
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
reactant: MODEL1310110022#
is described by: ECO:0000269
kinetic law: MODEL1310110022#
fast: false
is: SBO:0000185
modifier: MODEL1310110022#
name: bicarbonate transport (HCl/NaHCO3 exchange)
reversible: true
type: Reaction
product: MODEL1310110022#

metaR HISSNAT5tc
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_7279e417_214f_41a7_9b90_fc6136ff076d
initial amount: NaN
is: O75355
is: SBO:0000252
is encoded by: hsa:956
type: Species
constant: false
initial concentration: NaN
name: ENTPD3
has only substance units: false
boundary condition: true

metaM gly m
initial amount: NaN
name: Glycine
initial concentration: 1.0
is: C00037
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
is: HMDB00123
constant: false
is: CHEBI:15428
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species

metaM nmn c
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:14649
is: HMDB00229
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
boundary condition: false
type: Species
name: NMN
is: C00455
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110022#_4d608ab5_83e3_481c_8550_9e6151e8a2b5
type: Species
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:80025
initial amount: NaN
is: SBO:0000252
name: PANK2

http://identifiers.org/biomodels.db/MODEL1310110022#_254b1f07_049c_4c4d_907e_709116cf2f35
type: Species
boundary condition: true
name: ABO
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:28
has only substance units: false
is: P16442

http://identifiers.org/biomodels.db/MODEL1310110022#_36cb4147_d3f8_4380_9fc4_a4de8145da7a
has only substance units: false
name: PRPS2
is: P11908
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:5634
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110022#_273ec704_2488_4592_a885_605b852e6762
is: Q5FWE9
boundary condition: true
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:134526
name: ACOT12
initial concentration: NaN

metaM pail4p hs n
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
type: Species
has only substance units: false
is: CHEBI:58178
initial concentration: 1.0
constant: false

metaR r0650
type: Reaction
modifier: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000176
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
kinetic law: MODEL1310110022#
reversible: true
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/4.1.1.36
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
fast: false
is described by: ECO:0000000

metaR r1583
reversible: true
is described by: ECO:0000000
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110022#
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_23c47f5e_6d20_458c_a34c_73aeb218ef1a
has only substance units: false
constant: false
type: Species
boundary condition: true
is: Q6IBA0
is: SBO:0000252
is encoded by: hsa:4725
initial amount: NaN
name: NDUFS5
initial concentration: NaN

metaR RE1709N
is described by: ECO:0000000
kinetic law: MODEL1310110022#
fast: false
type: Reaction
product: MODEL1310110022#
reactant: MODEL1310110022#
reversible: true
is: SBO:0000176
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
name: RE1709
is version of: http://identifiers.org/ec-code/4.2.1.96

metaM gluside hs g
initial concentration: 1.0
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
boundary condition: false
type: Species
name: D-glucosyl-N-acylsphingosine
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:18368

http://identifiers.org/biomodels.db/MODEL1310110022#_63b9e7db_595b_4e50_94f2_dffb44b3b641
initial amount: NaN
constant: false
boundary condition: true
name: NT5C1B
has only substance units: false
is: B3KUK6
type: Species
is: SBO:0000252
is encoded by: hsa:93034
initial concentration: NaN

metaR GCALDD
kinetic law: MODEL1310110022#
reversible: false
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.2.1.3
name: Glycolaldehyde dehydrogenase
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:11434452 NOTES:JLR
is version of: http://identifiers.org/ec-code/1.2.1.36
reactant: MODEL1310110022#
is described by: ECO:0000304
product: MODEL1310110022#
type: Reaction
is: SBO:0000176

metaR r1619
product: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
reactant: MODEL1310110022#
fast: false
is described by: ECO:0000000

metaR RE2814M
reversible: true
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
is: SBO:0000176
fast: false
is described by: ECO:0000000
type: Reaction
name: RE2814
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#

metaR DHORD9
name: dihydoorotic acid dehydrogenase (quinone10)
is: SBO:0000185
type: Reaction
modifier: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: (1723.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 1.3.3.1 Confidence Level: 4 AUTHORS: PMID:10727948,PMID:9693067 NOTES:_06-15-05 - EC 1.3.3.1 IT based on Bader et al, 1998, Prot. Expr. Purif,., 13,414-422 (I guess it is ubiquinone but i am not sure ) (needs FMN as cofactor) v(enzyme is located in inner-membrane of mitochondria, reaction take place in cytosol (Fig. 8 Rawls et al PMID: 10727948 )
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.5.2
reversible: false
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_8a5900df_97d4_4eff_84a3_ad673189794f
is: P04745
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: AMY1C
is: SBO:0000252
is encoded by: hsa:278
type: Species

metaM dag hs c
name: diglyceride
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:18035
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN

metaR DNDPt41m
type: Reaction
product: MODEL1310110022#
reversible: false
name: dUTP transport via dCDP antiport
is described by: ECO:0000269
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
is: SBO:0000185
fast: false

metaM amp m
is: SBO:0000247
name: AMP(2-)
is: HMDB00045
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
constant: false
is: CHEBI:456215
type: Species
boundary condition: false

metaR r1832
kinetic law: MODEL1310110022#
name: Y+LAT2 Utilized transport
is: SBO:0000185
product: MODEL1310110022#
is described by: ECO:0000000
reversible: false
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110022#
type: Reaction
modifier: MODEL1310110022#

metaR r0578
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
reversible: true
modifier: MODEL1310110022#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/4.1.2.27
type: Reaction
is: SBO:0000176
reactant: MODEL1310110022#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
product: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_eacc406d_5d91_44a9_b2a0_3967db417db6
initial concentration: NaN
type: Species
initial amount: NaN
is: O95436
boundary condition: true
is: SBO:0000252
name: SLC34A2
has only substance units: false
is encoded by: hsa:10568
constant: false

metaM biocyt e
boundary condition: false
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
is: C05552
is: SBO:0000247
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
is: HMDB03134
is: http://identifiers.org/pubchem.compound/7886
initial amount: NaN
name: Biocytin

metaR PI45PLC
reactant: MODEL1310110022#
is: SBO:0000176
name: phosphatidylinositol 4,5-bisphosphate phospholipase C
is described by: ECO:0000000
fast: false
product: MODEL1310110022#
reversible: false
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.11

http://identifiers.org/biomodels.db/MODEL1310110022#_26aab7b3_73ed_4841_93e7_a3c74e9d0c47
is: P43353
boundary condition: true
is encoded by: hsa:221
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
name: ALDH3B1

metaM ala D e
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
is: HMDB01310
is: CHEBI:15570
is: SBO:0000247
name: D-alanine
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
constant: false
initial concentration: 1.0

metaR GLXO1
reactant: MODEL1310110022#
type: Reaction
fast: false
name: glyoxylate oxidase
is version of: http://identifiers.org/ec-code/1.1.1.27
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3939.1) or (55293.1) or (3945.1 and 3939.1) or (197257.1) or (92483.1) or (3945.1) or (160287.1) or (3948.1) or (197257.2) or (3948.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.3.5 Confidence Level: 4 AUTHORS: PMID:12768081,PMID:9038835,PMID:9604807,PMID:9783918 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.2.4
product: MODEL1310110022#
is described by: ECO:0000269
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#

metaR MECOALm
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
is version of: http://identifiers.org/ec-code/6.2.1.5
kinetic law: MODEL1310110022#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.4
reactant: MODEL1310110022#
type: Reaction
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
modifier: MODEL1310110022#
fast: false
product: MODEL1310110022#

metaR PNTOte
type: Reaction
name: Transport of (R)-Pantothenate
kinetic law: MODEL1310110022#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110022#
is described by: ECO:0000134
reactant: MODEL1310110022#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110022#_6ee6a232_d11e_456e_8edb_f9b70e377830
name: ALDH2
boundary condition: true
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is: P05091
is: SBO:0000252
is encoded by: hsa:217

metaR r0579
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.13.11.19
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
modifier: MODEL1310110022#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
product: MODEL1310110022#
type: Reaction
is: SBO:0000176

metaR r1726
fast: false
type: Reaction
reversible: false
name: Y+LAT2 Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000000
product: MODEL1310110022#
kinetic law: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_332507fc_0efa_4968_8baa_bf676d5a10a2
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: CHKB
is: SBO:0000252
is encoded by: hsa:1120
type: Species
is: Q9Y259

metaR PSFLIPm
is version of: http://identifiers.org/ec-code/3.6.3.1
product: MODEL1310110022#
fast: false
modifier: MODEL1310110022#
name: phosphatidylserine flippase
is described by: ECO:0000269
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ
type: Reaction
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#

metaM clpn hs c
boundary condition: false
is: SBO:0000247
name: clpn_hs[c]
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
initial amount: NaN
notes: FORMULA: CHARGE: 0
is: HMDB02704
is: CHEBI:21338

metaR G6PDH1rer
type: Reaction
reactant: MODEL1310110022#
modifier: MODEL1310110022#
is: SBO:0000176
product: MODEL1310110022#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.47
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:tv, jp NCD
name: glucose-6-phosphate dehydrogenase, endoplasmic reticulum
is described by: ECO:0000269

metaR XYLtly
name: Xylose efflux from lysosome
is described by: ECO:0000000
reversible: false
product: MODEL1310110022#
kinetic law: MODEL1310110022#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110022#

metaM dsT antigen g
name: disialyl-T antigen
initial concentration: 1.0
is: CHEBI:16497
notes: FORMULA: C36H56N3O26X CHARGE: -2
is: HMDB01440
has only substance units: false
initial amount: NaN
type: Species
constant: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110022#_b1b3831c_c7d8_4186_8165_d162d079f969
name: _H53099_1_m
has only substance units: false
boundary condition: true
is encoded by: hsa:H53099
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaM spc hs e
boundary condition: false
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5311445
initial amount: NaN
type: Species
name: sphingosylphosphorylcholine
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_58390ecd_ca6a_4c38_b00d_2521e28257c0
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:9167
name: COX7A2L
is: Q6FGA0
has only substance units: false
boundary condition: true
type: Species

metaR r0022
type: Reaction
reactant: MODEL1310110022#
fast: false
is: SBO:0000176
modifier: MODEL1310110022#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110022#
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.8.1.7
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:

metaM ascb L c
is: CHEBI:38290
is: HMDB00044
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: L-ascorbate
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
type: Species
constant: false
initial concentration: 1.0
has only substance units: false

metaM gthrd m
name: glutathionate(1-)
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB00125
has only substance units: false
is: CHEBI:57925
constant: false
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051

metaM amp x
type: Species
is: SBO:0000247
name: AMP
boundary condition: false
is: C00020
constant: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: CHEBI:456215
initial concentration: 1.0
is: HMDB00045
initial amount: NaN
has only substance units: false

metaM udpg c
is: C00029
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:58367
name: UDPglucose
initial concentration: 1.0
is: HMDB00286
boundary condition: false
constant: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
is: SBO:0000247

metaM 2mpdhl m
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C12H23NO2S2 CHARGE: 0 INCHI: InChI=1S/C12H23NO2S2/c1-9(2)12(15)17-8-7-10(16)5-3-4-6-11(13)14/h9-10,16H,3-8H2,1-2H3,(H2,13,14) EHMN_ABBREVIATION: C04424
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: S-(2-Methylpropanoyl)-dihydrolipoamide
is: CHEBI:17577

metaM glc D e
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
name: D-glucose
is: CHEBI:4167
is: HMDB00122
constant: false

metaR r1951
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
kinetic law: MODEL1310110022#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110022#
type: Reaction
modifier: MODEL1310110022#
reactant: MODEL1310110022#
fast: false

metaR TAUPAT1c
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of taurine into the intestinal cells by PAT1
type: Reaction

metaR r1051
reactant: MODEL1310110022#
product: MODEL1310110022#
type: Reaction
kinetic law: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
reversible: true
name: Vesicular transport
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110022#_c3dd4847_0daa_4d31_b784_96635a1c4285
name: SLC16A10
type: Species
is encoded by: hsa:117247
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: Q8TF71

metaM drib e
type: Species
name: 2-deoxy-D-ribose
is: SBO:0000247
is: HMDB03224
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:28816
has only substance units: false

metaM fucacgalfucgalacglcgalgluside hs c
boundary condition: false
constant: false
is: HMDB00961
initial concentration: 1.0
type: Species
notes: FORMULA: C64H112N3O35FULLRCO CHARGE: 0
initial amount: NaN
is: CHEBI:175763
has only substance units: false
name: (Gal)2 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)2 (Cer)1
is: SBO:0000247
is: C00448

metaR PGDI
name: Prostaglandin-H2 D-isomerase [Precursor]
is version of: http://identifiers.org/ec-code/5.3.99.2
is described by: ECO:0000269
modifier: MODEL1310110022#
reactant: MODEL1310110022#
fast: false
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.5.1.18
type: Reaction
product: MODEL1310110022#

metaM retinol e
name: retinol
is: HMDB00305
type: Species
has only substance units: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
is: CHEBI:50211
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247

metaR r0021
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
type: Reaction
kinetic law: MODEL1310110022#
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.6.1.5
is: SBO:0000176
modifier: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000000
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110022#_ea8bc0fd_36a5_4351_8e8b_73b52795812b
is encoded by: hsa:23417
initial amount: NaN
type: Species
is: O95822
name: MLYCD
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110022#_325aeec1_715d_483f_9698_3f04d4767888
name: LSS
is: E9PEI9
is encoded by: hsa:4047
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
constant: false

metaM ahcys c
is: C00021
is: HMDB00939
name: S-Adenosyl-L-homocysteine
is: SBO:0000247
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
constant: false
type: Species
is: CHEBI:16680
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaM h2o2 m
type: Species
initial amount: NaN
is: C00027
is: HMDB03125
name: Hydrogen peroxide
has only substance units: false
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
boundary condition: false
is: SBO:0000247
is: CHEBI:16240
initial concentration: 1.0
constant: false

metaR r0921
kinetic law: MODEL1310110022#
type: Reaction
reversible: false
reactant: MODEL1310110022#
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110022#
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12006583,PMID:1260500,PMID:12838422,PMID:14747464,PMID:16595656,PMID:168203,PMID:17187757,PMID:17279066,PMID:3728675,PMID:6778226,PMID:7419607,PMID:7479738,PMID:8438778 NOTES:

metaR r0587
type: Reaction
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
is: SBO:0000176
reactant: MODEL1310110022#
fast: false
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.2.1.5
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1

metaR r0641
product: MODEL1310110022#
reactant: MODEL1310110022#
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.1.2.4
is: SBO:0000176
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

metaR ANTHte
kinetic law: MODEL1310110022#
reversible: true
product: MODEL1310110022#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
reactant: MODEL1310110022#
is described by: ECO:0000134
type: Reaction
name: Transport of anthranilate

metaM glx x
boundary condition: false
is: HMDB00119
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:36655
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
name: glyoxylate
type: Species
constant: false
has only substance units: false

metaR CYTK8n
reactant: MODEL1310110022#
is: SBO:0000176
kinetic law: MODEL1310110022#
fast: false
name: cytidylate kinase (CMP,dATP),nuclear
modifier: MODEL1310110022#
reversible: true
type: Reaction
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269

metaR GALASE4ly
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000
reversible: false
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110022#
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110022#
name: beta-galactosidase, lysosomal

metaR S6TASE17ly
product: MODEL1310110022#
is: SBO:0000176
kinetic law: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
fast: false
is described by: ECO:0000000
reactant: MODEL1310110022#
name: N-acetylglucosamine-6-sulfatase, lysosomal
modifier: MODEL1310110022#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.14

metaR r1050
name: Vesicular transport
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110022#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110022#_5bfe6180_ae9c_4552_a005_dc135fc18b22
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AA177072
initial amount: NaN
boundary condition: true
name: _AA177072_1_c
is: SBO:0000252

metaR NACHEX12ly
type: Reaction
modifier: MODEL1310110022#
product: MODEL1310110022#
fast: false
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110022#
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52

metaM apoC Lys btn c
is: CHEBI:32551
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C16H27N4O3SX CHARGE: 0
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
is: HMDB00182

metaR ACGAMPM
reversible: true
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
product: MODEL1310110022#
is: SBO:0000176
fast: false
name: phosphoacetylglucosamine mutase
is described by: ECO:0000269
modifier: MODEL1310110022#
type: Reaction
is version of: http://identifiers.org/ec-code/5.4.2.3
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD

metaR r0642
reversible: true
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
kinetic law: MODEL1310110022#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:

metaM h2o2 n
initial amount: NaN
name: hydrogen peroxide
boundary condition: false
is: SBO:0000247
is: CHEBI:16240
constant: false
type: Species
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
has only substance units: false
initial concentration: 1.0
is: HMDB03125

http://identifiers.org/biomodels.db/MODEL1310110022#_f9fd299b_635f_4958_bc32_cca93e4bbae1
is: Q9H0N5
is: SBO:0000252
name: PCBD2
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:84105
has only substance units: false
constant: false
initial amount: NaN

metaM 56dura c
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
initial concentration: 1.0
has only substance units: false
name: 5,6-dihydrouracil
boundary condition: false
is: HMDB00076
is: CHEBI:15901
type: Species
is: SBO:0000247
initial amount: NaN
constant: false

metaM retinol c
has only substance units: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
type: Species
is: HMDB00305
boundary condition: false
initial concentration: 1.0
is: CHEBI:50211
initial amount: NaN
constant: false
name: retinol
is: SBO:0000247

metaR H2Oter
kinetic law: MODEL1310110022#
name: H2O endoplasmic reticulum transport
is: SBO:0000185
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_f5c323c6_4047_41fb_9255_6017361fee19
is encoded by: hsa:8395
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
name: PIP5K1B
type: Species
is: O14986
initial amount: NaN

metaM mercppyr c
constant: false
notes: FORMULA: C3H3O3S CHARGE: -1 INCHI: InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00600 EHMN_ABBREVIATION: C00957
initial concentration: 1.0
boundary condition: false
is: HMDB01368
has only substance units: false
name: 3-mercaptopyruvate
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:57678

metaM retinol 9 cis e
constant: false
is: HMDB06217
boundary condition: false
has only substance units: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
is: SBO:0000247
initial amount: NaN
type: Species
name: 9-cis-retinol
is: CHEBI:17336
initial concentration: 1.0

metaM accoa m
boundary condition: false
is: HMDB01206
type: Species
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
name: Acetyl-CoA
is: C00024
has only substance units: false
is: CHEBI:57288
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false

metaM crn r
name: (R)-carnitine
is: HMDB00062
boundary condition: false
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
constant: false
is: CHEBI:16347
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaM hs deg1 l
is: CHEBI:17180
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C79H115N5O99S11 CHARGE: -12
constant: false
name: heparan sulfate, degradation product 1
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
is: HMDB01352

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

metaM 4ppan c
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
initial concentration: 1.0
type: Species
is: CHEBI:10986
is: C03492
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: D-4'-Phosphopantothenate
constant: false
is: HMDB01016

metaR ABUTt2r
reversible: true
reactant: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r
type: Reaction
product: MODEL1310110022#
is described by: ECO:0000304
name: 4-aminobutyrate reversible transport in via proton symport
is: SBO:0000185
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_3ccce729_448e_4f1d_828b_5434f3e54e84
has only substance units: false
name: SCD
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: O00767
is encoded by: hsa:6319
type: Species
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_973d257d_6759_4b15_83f8_c6ef34e9bfb0
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is: F5H066
is: SBO:0000252
boundary condition: true
name: SLC12A4
is encoded by: hsa:6560

metaR r1377
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
fast: false
type: Reaction
is described by: ECO:0000000
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22

metaM accoa n
is: CHEBI:57288
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
name: acetyl-CoA(4-)
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB01206

metaR EX fucacgalfucgalacglcgalgluside hs LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (Gal)2 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)2 (Cer)1 exchange
type: Reaction

metaR RDH2a
is version of: http://identifiers.org/ec-code/1.1.1.105
reactant: MODEL1310110022#
is: SBO:0000176
notes: GENE_ASSOCIATION: (195814.1) or (112724.1) or (145226.1) or (51109.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12435598,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
is described by: ECO:0000269
modifier: MODEL1310110022#
type: Reaction
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.1.1.300
kinetic law: MODEL1310110022#
reversible: true
name: retinol dehydrogenase (9-cis,NADPH)
fast: false

http://identifiers.org/biomodels.db/MODEL1310110022#_d76ece84_ece4_4bea_8ac4_f39d89380c72
is: A8K7W0
type: Species
is encoded by: hsa:8875
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
name: VNN2

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

metaR DM Asn X Ser Thr ly
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Asn-X-Ser/Thr(ly)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_d72d65e3_1cb7_4b2d_855c_9c0c0677de33
type: Species
name: CROT
boundary condition: true
is: E7EQF2
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:54677

metaR r0644
reversible: true
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
type: Reaction
is described by: ECO:0000000
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
reactant: MODEL1310110022#
fast: false
is: SBO:0000176
product: MODEL1310110022#

metaR r0584
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.2.1.5
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
is: SBO:0000176
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110022#
product: MODEL1310110022#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110022#_d92a65bf_3c8f_4116_aec7_fd463d997da2
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: P23677
is encoded by: hsa:3706
boundary condition: true
type: Species
is: SBO:0000252
name: ITPKA

http://identifiers.org/biomodels.db/MODEL1310110022#_3d6d9dfb_28a2_4f1c_b646_8ae856f8bab0
initial concentration: NaN
is: P35475
boundary condition: true
type: Species
is encoded by: hsa:3425
constant: false
initial amount: NaN
name: IDUA
has only substance units: false
is: SBO:0000252

metaR PItn
kinetic law: MODEL1310110022#
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110022#
name: phosphate transport, nuclear

http://identifiers.org/biomodels.db/MODEL1310110022#_18e06f0e_403b_4352_a106_2468d0d4e441
type: Species
is: P22352
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
name: GPX3
is encoded by: hsa:2878

metaR KYNAKGAT
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB
is described by: ECO:0000269
fast: false
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.6.1.7
reversible: false
reactant: MODEL1310110022#
modifier: MODEL1310110022#
name: L-Kynurenine:2-oxoglutarate aminotransferase
kinetic law: MODEL1310110022#
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.64
is: SBO:0000176

metaM Tn antigen l
notes: FORMULA: C8H14NO5X CHARGE: 0
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
has only substance units: false
is: C04383
initial amount: NaN
is: SBO:0000247
name: Tn antigen

metaR r0797
is described by: ECO:0000000
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
reversible: true
fast: false
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
is: SBO:0000176
product: MODEL1310110022#
name: glycine N-choloyltransferase EC:2.3.1.65

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_068c6514_a1a6_4674_aa83_a07372a478b1
is encoded by: hsa:AL038231
constant: false
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: _AL038231_1_c

http://identifiers.org/biomodels.db/MODEL1310110022#_dec7c7ac_feeb_483f_ba63_674827b2a97e
has only substance units: false
is: Q6ZMR3
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:160287
name: LDHAL6A
constant: false
is: SBO:0000252

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_63ac7271_5b11_49c6_91f9_d7cbb01e0806
initial amount: NaN
name: CA12
boundary condition: true
is: O43570
constant: false
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:771

metaM spc hs c
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
name: sphingosylphosphorylcholine
is: http://identifiers.org/pubchem.compound/5311445
has only substance units: false
initial amount: NaN
boundary condition: false

metaR EX tcynt LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

metaM drib c
is: HMDB03224
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: 2-deoxy-D-ribose
constant: false
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
is: CHEBI:28816
is: SBO:0000247
type: Species

metaR r1378
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
product: MODEL1310110022#
type: Reaction
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
is described by: ECO:0000000
reversible: true
fast: false

metaR EX 2mcit LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Methylcitrate exchange
type: Reaction

metaR PROSTGE2t
is described by: ECO:0000269
modifier: MODEL1310110022#
product: MODEL1310110022#
kinetic law: MODEL1310110022#
reversible: true
is: SBO:0000185
reactant: MODEL1310110022#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
name: prostaglandin transport via bicarbonate countertransport

metaR XANtx
is described by: ECO:0000000
kinetic law: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: false
type: Reaction
product: MODEL1310110022#
name: xanthine diffusion in peroxisome
reactant: MODEL1310110022#
is: SBO:0000185

metaR r0796
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
product: MODEL1310110022#
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
type: Reaction
is: SBO:0000176
modifier: MODEL1310110022#
fast: false
reactant: MODEL1310110022#
is described by: ECO:0000000
reversible: true

metaR GCC2am
reversible: true
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.2.10
product: MODEL1310110022#
reactant: MODEL1310110022#
name: glycine-cleavage complex (lipoamide), mitochondrial
modifier: MODEL1310110022#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.4.4.2
type: Reaction
is version of: http://identifiers.org/ec-code/1.8.1.4

metaM gcald c
is: SBO:0000247
initial amount: NaN
is: HMDB03344
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C2H4O2 CHARGE: 0 INCHI: InChI=1S/C2H4O2/c3-1-2-4/h1,4H,2H2 EHMN_ABBREVIATION: C00266
is: CHEBI:17071
type: Species
constant: false
name: glycolaldehyde

metaR TCHOLAt2
notes: GENE_ASSOCIATION: (6554.1) or (6555.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12851823,PMID:7592981,PMID:8132774,PMID:9109432 NOTES:electrogenic uptake NJ
is described by: ECO:0000269
fast: false
name: taurocholate transport via sodium cotransport
reactant: MODEL1310110022#
is: SBO:0000185
modifier: MODEL1310110022#
product: MODEL1310110022#
reversible: false
kinetic law: MODEL1310110022#
type: Reaction

metaM cytd e
initial amount: NaN
is: CHEBI:17562
has only substance units: false
type: Species
initial concentration: 1.0
name: Cytidine
is: C00475
boundary condition: false
is: HMDB00089
constant: false
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110022#_e7de7f93_5454_42ef_8e39_f38df0e8e33f
initial amount: NaN
is: SBO:0000252
constant: false
is: P30519
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:3163
name: HMOX2

metaR ACALDt
reactant: MODEL1310110022#
type: Reaction
product: MODEL1310110022#
name: acetaldehyde reversible transport
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110022#

metaM methf m
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57455
name: (6R)-5,10-methenyltetrahydrofolate
boundary condition: false
type: Species
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
constant: false
is: HMDB01354

metaR NP1
type: Reaction
is: SBO:0000176
modifier: MODEL1310110022#
is described by: ECO:0000304
name: nucleotide phosphatase
reversible: false
reactant: MODEL1310110022#
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.1
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: NAD metabolism EC Number: 3.4.2.1 Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_ac9e858a_ddda_43b2_9795_c9a1eb84b951
is: SBO:0000252
name: HAS3
is: Q96RV2
type: Species
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:3038

metaR r1156
type: Reaction
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
is described by: ECO:0000000
fast: false
product: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110022#
reversible: true

metaM Tn antigen g
has only substance units: false
name: Tn antigen
initial amount: NaN
type: Species
constant: false
is: C04383
is: SBO:0000247
boundary condition: false
notes: FORMULA: C8H14NO5X CHARGE: 0
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110022#_e21c23b6_3dd0_49b7_abbb_4d1cd55260bf
is: P33897
name: ABCD1
is: SBO:0000252
constant: false
is encoded by: hsa:215
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN

metaR r2133
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110022#
is described by: ECO:0000000
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction

metaM apoC Lys btn m
is: http://identifiers.org/pubchem.compound/7886
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C16H27N4O3SX CHARGE: 0
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
is: C05552
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
is: HMDB03134

metaR r2359
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110022#
fast: false
type: Reaction
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reversible: true
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport

metaR MTHFDm
fast: false
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.5.4.9
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/6.3.4.3
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
is: SBO:0000176
product: MODEL1310110022#
is described by: ECO:0000269
type: Reaction
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
reversible: true

metaM gthrd e
constant: false
boundary condition: false
initial amount: NaN
is: HMDB00125
initial concentration: 1.0
type: Species
name: glutathionate(1-)
has only substance units: false
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: CHEBI:57925
is: SBO:0000247

metaR r0647
reversible: true
reactant: MODEL1310110022#
type: Reaction
kinetic law: MODEL1310110022#
is described by: ECO:0000000
name: Spontaneous reaction
fast: false
product: MODEL1310110022#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:

metaM ins e
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
is: C00294
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:17596
name: Inosine
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB00195

http://identifiers.org/biomodels.db/MODEL1310110022#_760ab829_7704_4bbc_8453_ac12a67517c6
is encoded by: hsa:57818
is: E9PAX2
constant: false
type: Species
name: G6PC2
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110022#_244ae5cc_9fa0_4361_9c33_95f3d490b6d3
initial amount: NaN
is: SBO:0000252
is: P51648
is encoded by: hsa:224
constant: false
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
name: ALDH3A2

http://identifiers.org/biomodels.db/MODEL1310110022#_d9978b8c_14fa_4e1a_bb82_55fa8e08d68a
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
name: ADH5
is encoded by: hsa:128
is: Q6IRT1
constant: false
initial concentration: NaN

metaR GCHOLAte
type: Reaction
name: bile acid intracellular transport
is: SBO:0000185
fast: false
product: MODEL1310110022#
kinetic law: MODEL1310110022#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ

metaM ksi deg2 l
constant: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 2
type: Species
is: SBO:0000247
is: HMDB01356
initial amount: NaN
is: CHEBI:57312
has only substance units: false
boundary condition: false
notes: FORMULA: C241H384N17O210S12 CHARGE: -13

metaM itp e
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB00189
type: Species
is: CHEBI:57614
boundary condition: false
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
is: SBO:0000247
name: ITP(3-)
constant: false

metaM thyox L c
boundary condition: false
initial amount: NaN
has only substance units: false
name: L-thyroxine
initial concentration: 1.0
type: Species
is: HMDB00248
is: CHEBI:18332
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
constant: false
is: SBO:0000247

metaR MALSO4tm
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is: SBO:0000185
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
product: MODEL1310110022#
name: Malate:sulfate antiport, mitochondrial
fast: false
reversible: true

metaM ksi deg24 l
type: Species
initial concentration: 1.0
is: HMDB00143
boundary condition: false
is: CHEBI:12936
is: SBO:0000247
notes: FORMULA: C118H191N8O101S5 CHARGE: -5
name: keratan sulfate I, degradation product 24
has only substance units: false
initial amount: NaN
constant: false

metaM cytd c
initial amount: NaN
constant: false
name: Cytidine
initial concentration: 1.0
boundary condition: false
is: HMDB00089
is: CHEBI:17562
is: C00475
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475

metaR r2132
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reactant: MODEL1310110022#
modifier: MODEL1310110022#
reversible: true
product: MODEL1310110022#
type: Reaction
kinetic law: MODEL1310110022#
is described by: ECO:0000000

metaR r0580
modifier: MODEL1310110022#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.7
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
product: MODEL1310110022#
is: SBO:0000176
reactant: MODEL1310110022#
type: Reaction
reversible: true
kinetic law: MODEL1310110022#

metaR r2358
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
kinetic law: MODEL1310110022#
product: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_568f1311_d03a_4ed1_9f57_66420c5aa693
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:4967
is: Q02218
name: OGDH
has only substance units: false
constant: false
is: SBO:0000252

metaR APOC LYS BTNPm
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
is: SBO:0000176
type: Reaction
name: proteolysis of apoC-Lys-btn, mitochondrial
kinetic law: MODEL1310110022#
is described by: ECO:0000000
reactant: MODEL1310110022#
product: MODEL1310110022#
reversible: false

metaM h2o2 x
name: Hydrogen peroxide
constant: false
type: Species
is: C00027
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:16240
initial amount: NaN
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
boundary condition: false
is: HMDB03125

metaR GLNtN1
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
kinetic law: MODEL1310110022#
name: Glutamine transport (Na, H coupled)
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110022#
reactant: MODEL1310110022#
fast: false
product: MODEL1310110022#

metaR r1154
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110022#
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000176
name: EC:1.2.7.2
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 1.2.7.2 Confidence Level: 0 AUTHORS: PMID:2649080,PMID:283398,PMID:3718468,PMID:9381974 NOTES:

metaM Asn X Ser Thr l
constant: false
initial amount: NaN
name: protein-linked asparagine residue (N-glycosylation site)
is: C01342
is: HMDB00051
type: Species
initial concentration: 1.0
is: CHEBI:28938
boundary condition: false
is: SBO:0000247
notes: FORMULA: XH CHARGE: 0
has only substance units: false

metaR r2131
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
product: MODEL1310110022#
is: SBO:0000185
modifier: MODEL1310110022#

MODEL1310110022
species: metaM ahcys c
reaction: metaR PPItm
reaction: metaR CO2t
species: metaM 34hpp e
species: metaM 1p3h5c m
reaction: metaR FUCACGALFUCGALACGLCGALGLUSIDEtg
species: metaM f1a g
species: metaM ksi deg6 l
reaction: metaR r0502
species: metaM udpglcur r
species: metaM HC02210 c
species: metaM ser D e
reaction: metaR FATP3t
species: metaM pchol hs g
species: metaM 3m4hpga c
reaction: metaR RE0691C
reaction: metaR TRPt
reaction: metaR EX orot LPAREN e RPAREN
reaction: metaR RE3272N
reaction: metaR r0390
species: metaM co2 r
reaction: metaR r1626
species: metaM gly m
species: metaM 56dthm c
species: metaM biliverd c
species: metaM 2dr5p c
reaction: metaR TCYNTtm
reaction: metaR r2117
species: metaM amp x
species: metaM Rtotal e
reaction: metaR r2354
reaction: metaR O2ter
species: metaM dad 2 e
species: metaM adp c
species: metaM C04849 e
species: metaM C02470 c
species: metaM fadh2 c
reaction: metaR r1594
reaction: metaR G5SADrm
species: metaM dctp c
reaction: metaR ANTHte
species: metaM cytd e
species: metaM pglyc hs c
species: metaM ksii core2 l
species: metaM dcdp c
reaction: metaR CYTK11n
reaction: metaR G6Pter
species: metaM apoC Lys btn m
species: metaM man l
reaction: metaR COAtm
species: metaM g1p c
reaction: metaR r0193
species: metaM o2s m
species: metaM trdrd c
reaction: metaR GGH 10FTHF5GLUe
reaction: metaR SERDGLNexR
species: metaM fucacgalfucgalacglcgalgluside hs c
reaction: metaR GCC2bim
reaction: metaR PPItx
species: metaM 10fthf6glu c
reaction: metaR NACHEX10ly
reaction: metaR r0191
reaction: metaR r0245
species: metaM gal l
species: metaM pail45p hs c
reaction: metaR r2088
reaction: metaR PPPGOm
species: metaM gua c
species: metaM ocdca c
species: metaM dcdp m
reaction: metaR 3MOX4HOXPGALDOX NADP
reaction: metaR H2Otm
reaction: metaR r0937
reaction: metaR r1662
reaction: metaR r0801
species: metaM itaccoa m
species: metaM triodthy c
reaction: metaR r2318
reaction: metaR UDPGLCter
reaction: metaR r2104

metaM crn c
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial concentration: 1.0
is: CHEBI:16347
is: HMDB00062
initial amount: NaN
constant: false
type: Species
is: C00318
boundary condition: false
name: L-Carnitine
has only substance units: false
is: SBO:0000247

metaR VALt5m
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110022#
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110022#
reactant: MODEL1310110022#
name: Valine reversible mitochondrial transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110022#_05e29792_7533_4d7d_b799_a73a158dcb0b
is encoded by: hsa:6569
constant: false
is: SBO:0000252
name: SLC34A1
is: Q7Z725
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species

metaR r2357
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110022#
fast: false
kinetic law: MODEL1310110022#
type: Reaction
product: MODEL1310110022#
name: Organic anion transporter 5 Utilized transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110022#_32a5fa38_5652_4469_ab51_410aa51a8967
is encoded by: hsa:93034
boundary condition: true
is: Q96P26
has only substance units: false
initial amount: NaN
type: Species
name: NT5C1B
is: SBO:0000252
initial concentration: NaN
constant: false

metaM itp c
initial amount: NaN
boundary condition: false
name: ITP(3-)
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:57614
is: HMDB00189
is: SBO:0000247
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_5254328a_e844_4f6e_b6b0_2843da144029
is encoded by: hsa:55808
constant: false
is: SBO:0000252
boundary condition: true
name: ST6GALNAC1
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is: Q9NSC7

metaM gly x
initial amount: NaN
is: HMDB00123
initial concentration: 1.0
is: CHEBI:15428
notes: FORMULA: C2H5NO2 CHARGE: 0 INCHI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
name: glycine
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species

metaM ins c
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
is: C00294
name: Inosine
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:17596
is: HMDB00195
constant: false
has only substance units: false

metaM thyox L e
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
boundary condition: false
initial amount: NaN
has only substance units: false
name: L-thyroxine
is: HMDB00248
type: Species
initial concentration: 1.0
is: CHEBI:18332
constant: false
is: SBO:0000247

metaR ADK3m
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.10
reactant: MODEL1310110022#
product: MODEL1310110022#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110022#
is described by: ECO:0000269
name: adentylate kinase (GTP)
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD

metaR RE2069C
fast: false
type: Reaction
product: MODEL1310110022#
name: RE2069
reversible: true
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11447235 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110022#
is described by: ECO:0000000

metaR r1155
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12107270,PMID:12739169,PMID:12829793,PMID:17245649,PMID:18375207,PMID:8476015,PMID:8557697,PMID:9786900 NOTES:
fast: false
product: MODEL1310110022#
kinetic law: MODEL1310110022#
name: TCDB:2.A.1.13.5 TCDB:2.A.1.13.1
reversible: false
reactant: MODEL1310110022#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110022#_6ed2c7ea_d823_4b44_ba0b_d58dd9ccfee2
name: ACOT8
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: O14734
boundary condition: true
is encoded by: hsa:10005

metaR RETNt
kinetic law: MODEL1310110022#
name: retinoic acid transport
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
type: Reaction
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110022#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110022#_981062ad_fd6f_40c7_b7f6_e88bf4578c30
has only substance units: false
is: SBO:0000252
is: O75106
type: Species
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:314
name: AOC2

metaR S3TASE2ly
fast: false
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110022#
is: SBO:0000176
reactant: MODEL1310110022#
product: MODEL1310110022#
name: N-acetylglucosamine-3-sulfatase, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD

metaM fuc1p L c
is: CHEBI:28319
is: HMDB01265
name: L-Fucose 1-phosphate
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C6H11O8P CHARGE: -2 INCHI: InChI=1S/C6H13O8P/c1-2-3(7)4(8)5(9)6(13-2)14-15(10,11)12/h2-9H,1H3,(H2,10,11,12)/t2-,3+,4+,5-,6?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01030
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false

metaM 4mzym int2 r
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB06838
type: Species
name: 4-Methylzymosterol intermediate 2
has only substance units: false
notes: FORMULA: C28H44O CHARGE: 0 INCHI: InChI=1/C28H44O/c1-18(2)8-7-9-19(3)22-12-13-24-21-10-11-23-20(4)26(29)15-17-28(23,6)25(21)14-16-27(22,24)5/h8,19-20,22-24H,7,9-17H2,1-6H3/t19-,20?,22?,23?,24?,27-,28+/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110022#_c81496f9_b513_4e44_ad71_6bd3a2758060
initial amount: NaN
is encoded by: hsa:93034
is: SBO:0000252
is: Q96P26
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
name: NT5C1B
constant: false

metaR r2356
kinetic law: MODEL1310110022#
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110022#
product: MODEL1310110022#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR r2130
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110022#
fast: false
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
reversible: true
product: MODEL1310110022#

metaR EX spmd LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of spermidine(3+)
type: Reaction

metaR THRGLYexR
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110022#
type: Reaction
is described by: ECO:0000304
product: MODEL1310110022#
is: SBO:0000185
reversible: true
reactant: MODEL1310110022#
fast: false
name: L-threonine/glycine reversible exchange
modifier: MODEL1310110022#

metaR GLYt2r
reversible: true
kinetic law: MODEL1310110022#
type: Reaction
is described by: ECO:0000304
modifier: MODEL1310110022#
fast: false
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110022#
name: glycine reversible transport via proton symport

metaR AMETr
product: MODEL1310110022#
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110022#
name: S-Adenosyl-L-methionine intracellular diffusion
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110022#

metaR NH4t3r
is described by: ECO:0000269
is: SBO:0000185
reversible: true
reactant: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
type: Reaction
modifier: MODEL1310110022#
name: ammonia transport via proton antiport
kinetic law: MODEL1310110022#
product: MODEL1310110022#

metaR BTND1
product: MODEL1310110022#
is: SBO:0000176
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:IT
modifier: MODEL1310110022#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.12
reversible: false
name: biotinidase (biotin)

metaR EX ksii core2 LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 2-linked) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_6c97d210_e34a_43ac_b19e_7e076d47a17f
initial concentration: NaN
name: NDUFB11
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q9NX14
constant: false
is encoded by: hsa:54539

metaM xyl D c
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
initial concentration: 1.0
name: aldehydo-D-xylose
type: Species
constant: false
is: CHEBI:15936
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false

metaR GAPD
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.
modifier: MODEL1310110022#
is: SBO:0000176
product: MODEL1310110022#
reactant: MODEL1310110022#
name: glyceraldehyde-3-phosphate dehydrogenase
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.12
kinetic law: MODEL1310110022#
type: Reaction
is described by: ECO:0000134

metaR r2355
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110022#
product: MODEL1310110022#
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_8b293164_3cca_4633_b2c8_af630ae5d119
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
name: AOC2
is encoded by: hsa:314
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_a5ce70c8_f2b5_4b3c_ac6b_e1e99b9cadbc
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: ALDOB
is encoded by: hsa:229
constant: false
is: P05062

metaR FOLt2le
is: SBO:0000185
name: folate transport via anion exchange
kinetic law: MODEL1310110022#
product: MODEL1310110022#
is described by: ECO:0000134
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110022#_058d61c4_b815_4cdc_9543_fa342f090314
initial amount: NaN
constant: false
initial concentration: NaN
name: DLD
is encoded by: hsa:1738
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
is: P09622

metaM fucacgalfucgalacglcgalgluside hs g
constant: false
has only substance units: false
boundary condition: false
is: HMDB00961
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:175763
type: Species
notes: FORMULA: C64H112N3O35FULLRCO CHARGE: 0
is: C00448
initial amount: NaN
name: (Gal)2 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)2 (Cer)1

metaM oh1 c
notes: FORMULA: HO CHARGE: -1
is: SBO:0000247
name: hydroxide ion
initial amount: NaN
is: C01328
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB01039
constant: false

metaR PItg
is described by: ECO:0000000
reversible: false
type: Reaction
reactant: MODEL1310110022#
name: phosphate transport, Golgi apparatus
fast: false
is: SBO:0000185
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_7fa5cb79_5e57_4de5_8fe0_36041fd20424
type: Species
is: SBO:0000252
is encoded by: hsa:6561
constant: false
has only substance units: false
name: SLC13A1
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: Q9BZW2

http://identifiers.org/biomodels.db/MODEL1310110022#_9dc0ae0f_d027_4276_97ed_b741d9550e7c
has only substance units: false
type: Species
constant: false
name: SLC15A2
is: Q16348
boundary condition: true
is encoded by: hsa:6565
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaM retinol 9 cis c
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:17336
name: 9-cis-retinol
is: SBO:0000247
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
constant: false
is: HMDB06217

metaR EX mercplaccys LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-mercaptolactate-cysteine disulfide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_5736d76d_4f7f_4a09_9a26_470045a21c79
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
name: _AI090874_1_c
boundary condition: true
is encoded by: hsa:AI090874
is: SBO:0000252

metaR r2354
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110022#
product: MODEL1310110022#
fast: false
reactant: MODEL1310110022#
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_79142c50_e260_4204_89ad_0e2b043f857d
is: SBO:0000252
boundary condition: true
name: SLC20A2
initial amount: NaN
is: B2RBR4
type: Species
has only substance units: false
is encoded by: hsa:6575
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_a70b7c16_e4af_4e52_8c89_5ab790650377
has only substance units: false
name: NDUFA13
type: Species
is encoded by: hsa:51079
constant: false
is: SBO:0000252
is: Q9P0J0
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR r2080
kinetic law: MODEL1310110022#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110022#
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_7a6bd6be_1491_4617_b09f_3b54aa24996a
is encoded by: hsa:11238
has only substance units: false
name: CA5B
is: Q9Y2D0
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252

metaR TCYNTt
fast: false
kinetic law: MODEL1310110022#
reversible: false
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110022#
type: Reaction
name: Thiocyanate transport via diffusion (cytosol to extracellular)

http://identifiers.org/biomodels.db/MODEL1310110022#_96f636dc_7a0d_40ea_b1da_1a4a74503027
initial amount: NaN
has only substance units: false
is: Q9Y619
is encoded by: hsa:10166
name: SLC25A15
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
type: Species

metaM T antigen g
is: SBO:0000247
notes: FORMULA: C14H24NO10X CHARGE: 0
is: CHEBI:22783
has only substance units: false
initial amount: NaN
name: T antigen (core 1)
boundary condition: false
type: Species
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110022#_e933d13f_9b52_488c_b993_0427d3a45087
constant: false
initial amount: NaN
is: SBO:0000252
is: Q15181
boundary condition: true
name: PPA1
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5464

http://identifiers.org/biomodels.db/MODEL1310110022#_e6d98ab3_5721_48d8_bd4b_831f3fa6c19d
initial amount: NaN
has only substance units: false
is encoded by: hsa:84693
type: Species
name: MCEE
initial concentration: NaN
constant: false
is: Q96PE7
is: SBO:0000252
boundary condition: true

metaR r2353
fast: false
type: Reaction
reactant: MODEL1310110022#
product: MODEL1310110022#
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110022#

metaM xyl D e
is: SBO:0000247
name: aldehydo-D-xylose
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:15936
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
initial amount: NaN
type: Species
constant: false

metaM HC01118 r
initial concentration: 1.0
is: CHEBI:57310
type: Species
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
name: presqualene diphosphate(3-)

metaR KYNATESYN
type: Reaction
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES:SAB name is a guess
is described by: ECO:0000000
reactant: MODEL1310110022#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110022#
name: 4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase
fast: false

metaM fucacgalfucgalacglcgalgluside hs e
boundary condition: false
is: HMDB00121
constant: false
initial concentration: 1.0
notes: FORMULA: C64H112N3O35FULLRCO CHARGE: 0
type: Species
is: SBO:0000247
name: (Gal)2 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)2 (Cer)1
initial amount: NaN
has only substance units: false

metaM gthrd c
has only substance units: false
name: Reduced glutathione
is: HMDB00125
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
constant: false
is: C00051
is: CHEBI:57925
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110022#_99b27276_144c_4e30_8e24_3a33519f7577
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AI378339
type: Species
constant: false
name: _AI378339_1_m
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_f7263fb6_2bb4_4e3c_9a4d_830c9ec40654
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:7086
boundary condition: true
initial concentration: NaN
is: E7EPA7
is: SBO:0000252
has only substance units: false
name: TKT

http://identifiers.org/biomodels.db/MODEL1310110022#_5f764094_dae3_4f4c_a6d6_7ea80e0eebef
constant: false
type: Species
has only substance units: false
is: Q86VV3
name: ENTPD1
initial concentration: NaN
is encoded by: hsa:953
initial amount: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110022#_d6b2423b_9d31_4891_a26a_737130373bcd
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:H17063
is: SBO:0000252
name: _H17063_1_c
type: Species

metaR MCLACCYSR
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:6945862 NOTES:MM
fast: false
reversible: false
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
name: 3-mercaptolactate:cysteine reductase
type: Reaction

metaR r2352
reactant: MODEL1310110022#
product: MODEL1310110022#
is described by: ECO:0000000
kinetic law: MODEL1310110022#
reversible: true
name: Organic anion transporter 5 Utilized transport
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR LYSOXp
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.4.3.14 Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957,PMID:6811962 NOTES:MM
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000176
type: Reaction
product: MODEL1310110022#
name: L-lysine oxidase, peroxisomal
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110022#_cbeb89a4_4563_4990_9700_b767bd0fa52f
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:79966
name: SCD5
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: Q86SK9
type: Species

metaM 5dpmev c
boundary condition: false
is: HMDB01090
name: (R)-5-Diphosphomevalonate
type: Species
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_740c8b2b_e782_45cd_9afe_57352851957b
initial concentration: NaN
name: HMBS
constant: false
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:3145
is: P08397

metaR r0027
modifier: MODEL1310110022#
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
product: MODEL1310110022#
kinetic law: MODEL1310110022#
fast: false
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.39
reactant: MODEL1310110022#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
type: Reaction

metaM kynate c
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:58454
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB00715
name: kynurenate
boundary condition: false

metaM ksii core2 deg4 l
is: HMDB01354
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:57455
notes: FORMULA: C58H95N5O43SX CHARGE: -1
name: keratan sulfate II (core 2-linked), degradation product 4
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN

metaM ctp c
is: C00063
boundary condition: false
has only substance units: false
type: Species
name: CTP
is: SBO:0000247
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: CHEBI:37563
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00082

metaM glc D c
name: D-glucose
is: HMDB00122
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:4167
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_e29df996_0e9d_4555_9130_b44edda8b704
type: Species
name: PPOX
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5498
constant: false
boundary condition: true
is: P50336
initial amount: NaN
has only substance units: false

metaR PHEMEtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV changed name to"tm" to indicate mitochondrial transport NCD
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
type: Reaction
is: SBO:0000185
name: Heme transport to cytosol
reversible: true
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110022#_93e60e03_0989_4bee_9b39_e7e4963d226c
is: B3KXN9
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:84890
name: ADO

metaR PPPG9tm
reactant: MODEL1310110022#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:14623258 NOTES:NCD. Benzodiazepine receptor PBR see also 17168567
fast: false
product: MODEL1310110022#
kinetic law: MODEL1310110022#
type: Reaction
name: protoporphyrinogen IX mitochondrial transport

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_f929ca2c_d66d_4d47_9389_510bcef2945e
name: UCKL1
boundary condition: true
constant: false
initial amount: NaN
is: Q53HM1
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:54963
initial concentration: NaN

metaM HC01104 e
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
constant: false
name: 4-nitrophenyl phosphate(2-)
is: CHEBI:61146
initial amount: NaN
is: SBO:0000247

metaM HC02175 e
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
is: CHEBI:27689
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
name: caprate
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaR r1599
kinetic law: MODEL1310110022#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110022#
product: MODEL1310110022#
is described by: ECO:0000000

metaR r2126
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
fast: false
modifier: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110022#_0cdc6c2e_7efd_4115_9d9c_a7d7fcc30e0f
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110022#_d47f08bb_d293_4808_bbb8_35ae7537a91a
is: P19961
name: AMY2B
is encoded by: hsa:280
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110022#_81f4adaa_f473_435f_8c7c_07479c742074
has only substance units: false
initial concentration: NaN
has part: Q96I99
is encoded by: hsa:8802
constant: false
has part: P53597
name: SUCLG2:SUCLG1
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000297
is encoded by: hsa:8801

http://identifiers.org/biomodels.db/MODEL1310110022#_dd53402b_ad69_44dd_8bb1_163a476b0787
has only substance units: false
is: P27707
name: DCK
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1633
type: Species

metaM m2mn l
is: SBO:0000247
name: (alpha-D-mannosyl)2-beta-D-mannosyl-N-acetylglucosamine
boundary condition: false
is: HMDB06537
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C26H45NO21 CHARGE: 0 INCHI: InChI=1/C26H45NO21/c1-6(32)27-11-15(36)20(10(5-31)42-23(11)41)46-25-18(39)22(14(35)8(3-29)44-25)48-26-19(40)21(13(34)9(4-30)45-26)47-24-17(38)16(37)12(33)7(2-28)43-24/h7-26,28-31,33-41H,2-5H2,1H3,(H,27,32)/t7-,8-,9-,10+,11+,12-,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23+,24-,25+,26+/m0/s1
type: Species
has only substance units: false

metaR r2082
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
product: MODEL1310110022#
kinetic law: MODEL1310110022#
is described by: ECO:0000000
fast: false
is: SBO:0000185
modifier: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110022#_aaf4b17a_6e82_4ea1_a1e0_7e22409b3408
boundary condition: true
name: NDUFA7
is: Q6FG42
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4701
constant: false
initial amount: NaN

metaM ksii core2 l
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
name: keratan sulfate II (core 2-linked)
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB00189
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:57614

http://identifiers.org/biomodels.db/MODEL1310110022#_d6d329ea_ee5c_4add_8d2f_8788c5f51156
has only substance units: false
is encoded by: hsa:F23536
constant: false
name: _F23536_1_m
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_5005ad79_3cca_4c44_81eb_1d539408f81d
is encoded by: hsa:80025
type: Species
is: Q6P1K9
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: PANK2
constant: false

metaM udpg r
is: CHEBI:58367
boundary condition: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
is: HMDB00286

http://identifiers.org/biomodels.db/MODEL1310110022#_8efd9295_b6c7_487e_8b26_1febd8b06d7c
is encoded by: hsa:953
type: Species
is: Q86VV3
name: ENTPD1
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_64dd8280_d7b6_4c2d_b519_7d4db72b245a
name: COX8A
is: Q53XN1
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:1351
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252

metaM oh1 e
type: Species
is: SBO:0000247
is: HMDB01039
has only substance units: false
is: C01328
notes: FORMULA: HO CHARGE: -1
constant: false
name: hydroxide ion
initial amount: NaN
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110022#_4d768652_e0f5_409d_8f7d_329758019206
is: SBO:0000252
is encoded by: hsa:43
initial amount: NaN
initial concentration: NaN
name: ACHE
type: Species
is: P22303
has only substance units: false
constant: false
boundary condition: true

metaM crm hs e
name: N-acylsphingosine
boundary condition: false
has only substance units: false
is: CHEBI:52639
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195

http://identifiers.org/biomodels.db/MODEL1310110022#_74125fdb_961a_4ef7_a350_c09a0285e2d8
has only substance units: false
initial amount: NaN
constant: false
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: _W74642_1_c
is encoded by: hsa:W74642

metaR r1598
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110022#
reversible: true
kinetic law: MODEL1310110022#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM nadp m
has only substance units: false
is: CHEBI:58349
type: Species
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
constant: false
is: C00006
is: SBO:0000247
is: HMDB00217
name: Nicotinamide adenine dinucleotide phosphate
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaM dhf c
initial amount: NaN
is: CHEBI:57451
is: HMDB01056
has only substance units: false
is: C00415
initial concentration: 1.0
name: 7,8-Dihydrofolate
boundary condition: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
type: Species
is: SBO:0000247
constant: false

metaR r0879
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11287335,PMID:11327718 NOTES:
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110022#
name: TCDB:2.A.29.2.4 TCDB:2.A.29.16.1

metaR FUT12g
name: Galactoside 2-alpha-L-fucosyltransferase 1
reversible: false
kinetic law: MODEL1310110022#
is: SBO:0000176
modifier: MODEL1310110022#
reactant: MODEL1310110022#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.4.1.69
type: Reaction
product: MODEL1310110022#

metaR r2127
reactant: MODEL1310110022#
is: SBO:0000185
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110022#

metaR r0345
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110022#
reversible: true
product: MODEL1310110022#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.99.13
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
is: SBO:0000176

metaM ksi deg7 l
is: CHEBI:57455
boundary condition: false
constant: false
name: keratan sulfate I, degradation product 7
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB01354
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C210H337N15O181S10 CHARGE: -10

metaR BTNPLm
name: holocarboxylase synthestase (biotin protein ligase), mitochondrial
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
is described by: ECO:0000000
kinetic law: MODEL1310110022#
type: Reaction
is: SBO:0000176
product: MODEL1310110022#
reversible: false
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/6.3.4.10
reactant: MODEL1310110022#
fast: false

metaM dcdp m
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:58593
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: SBO:0000247
name: dCDP(3-)
is: HMDB01245
type: Species
has only substance units: false

metaR r2081
product: MODEL1310110022#
kinetic law: MODEL1310110022#
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110022#

metaM CE4872 m
has only substance units: false
is: CHEBI:15748
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
initial concentration: 1.0
constant: false
is: HMDB00127
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species

metaR S6TASE10ly
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110022#
kinetic law: MODEL1310110022#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
name: galactose-6-sulfate sulfatase, lysosomal
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110022#
reactant: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_837c046e_f83d_451a_8daf_52375011d327
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:221
is: P43353
name: ALDH3B1
boundary condition: true
has only substance units: false

metaM cdp c
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
name: CDP
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB01546
is: C00112
is: CHEBI:58069

metaR r2128
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reactant: MODEL1310110022#
product: MODEL1310110022#
is: SBO:0000185
modifier: MODEL1310110022#
is described by: ECO:0000000
reversible: true

metaR DM Ser Gly Ala X Gly ly
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser-Gly/Ala-X-Gly(ly)
type: Reaction

metaM HC02205 e
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
is: SBO:0000247
name: prostaglandin-b2
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:28099

metaM HC02175 c
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:27689
type: Species
initial concentration: 1.0
has only substance units: false
name: caprate
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_f1293b1e_3b3a_477c_a4bd_a38d30d36050
is: Q96KH8
initial amount: NaN
name: SLC6A2
initial concentration: NaN
is encoded by: hsa:6530
is: SBO:0000252
type: Species
boundary condition: true
constant: false
has only substance units: false

metaM acmana e
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
type: Species
boundary condition: false
constant: false
has only substance units: false
is: HMDB01129
initial concentration: 1.0
name: N-acetyl-D-mannosamine
is: CHEBI:17122

http://identifiers.org/biomodels.db/MODEL1310110022#_f2f5316a_8c18_4e56_9dcf_88b7cc66d120
constant: false
is: SBO:0000252
is encoded by: hsa:7263
has only substance units: false
initial concentration: NaN
type: Species
is: Q16762
initial amount: NaN
name: TST
boundary condition: true

metaR GALNTg
fast: false
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (26290.1) or (79695.1) or (2589.1) or (50614.1) or (8693.1) or (55568.2) or (114805.1) or (11226.1) or (117248.1) or (11227.1) or (55568.1) or (2590.1) or (51809.1) or (26290.1) or (79623.1) or (63917.1) or (2591.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.41 Confidence Level: 0 AUTHORS: PMID:10767557,PMID:12417297,PMID:12507512,PMID:12634319,PMID:15147861,PMID:9765313 NOTES:NCD
reactant: MODEL1310110022#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.4.1.41
modifier: MODEL1310110022#
name: GalNAc transferase, Golgi apparatus
type: Reaction

metaR r2084
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110022#
fast: false
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
modifier: MODEL1310110022#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM omhdocosac r
constant: false
notes: FORMULA: C22H42O3 CHARGE: -1
has only substance units: false
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/5282922
is: SBO:0000247
initial concentration: 1.0
name: w-hydroxydocosanoicacid
initial amount: NaN

metaM mal L c
name: (S)-malate(2-)
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB00156
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:15589

metaM dadp c
boundary condition: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
type: Species
name: dADP
initial amount: NaN
has only substance units: false
is: C00206
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01508
is: CHEBI:57667

metaM crm hs c
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: N-acylsphingosine
boundary condition: false
is: CHEBI:52639
type: Species
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
initial concentration: 1.0
constant: false

metaR r2129
product: MODEL1310110022#
is: SBO:0000185
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reactant: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_b9e0a19d_7224_43c4_8d52_a5da19500063
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
name: SLC22A2
is: O15244
is encoded by: hsa:6582

http://identifiers.org/biomodels.db/MODEL1310110022#_fda160e5_b1fd_4e90_83da_8483a54e268e
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
name: _AI469183_1_x
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AI469183
type: Species

metaM 5adtststerone e
has only substance units: false
is: HMDB02961
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:16330
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
initial concentration: 1.0
constant: false
name: 17beta-hydroxy-5alpha-androstan-3-one
type: Species

metaR HSPASEly
type: Reaction
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:12782143,PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
kinetic law: MODEL1310110022#
fast: false
name: heparan sulfate proteoglycan protease, lysosome (endosome)
reactant: MODEL1310110022#
is described by: ECO:0000000
product: MODEL1310110022#

metaR EX 10fthf6glu LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](6) exchange
type: Reaction

metaR NACHORCTL3le
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: NACHORCTL3le
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_a83e191f_8265_48a6_96c8_64f9e87741be
constant: false
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:284111
name: SLC13A5
initial concentration: NaN
is: Q86YT5

http://identifiers.org/biomodels.db/MODEL1310110022#_3c43a431_ef4e_4bc1_a396_f53e4dde3c6e
has only substance units: false
is encoded by: hsa:5162
constant: false
is: SBO:0000252
type: Species
is: P11177
initial amount: NaN
name: PDHB
boundary condition: true
initial concentration: NaN

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

metaR r2083
modifier: MODEL1310110022#
is: SBO:0000185
product: MODEL1310110022#
fast: false
reversible: true
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110022#_bd4e8129_9b05_492a_8500_8cffcb6facca
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:3290
name: HSD11B1
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_d04e04f4_8ec6_49ca_aad4_065cfd6471ef
constant: false
boundary condition: true
initial amount: NaN
is: P55084
name: HADHB
is: SBO:0000252
is encoded by: hsa:3032
initial concentration: NaN
type: Species
has only substance units: false

metaM glyb m
name: glycine betaine
has only substance units: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
is: CHEBI:17750
is: HMDB00043
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
boundary condition: false

metaM HC02205 c
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
type: Species
initial amount: NaN
is: CHEBI:28099
name: prostaglandin-b2

http://identifiers.org/biomodels.db/MODEL1310110022#_25d85601_e3ec_4018_be45_fa1a1a320022
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
name: SLC38A3
type: Species
constant: false
is: Q99624
is encoded by: hsa:10991
initial amount: NaN

metaM ksi deg26 l
constant: false
is: SBO:0000247
is: C00092
is: HMDB01401
name: keratan sulfate I, degradation product 26
notes: FORMULA: C110H179N7O93S4 CHARGE: -4
has only substance units: false
initial amount: NaN
is: CHEBI:61548
type: Species
boundary condition: false
initial concentration: 1.0

metaR EX udp LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP exchange
type: Reaction

metaM nadp r
initial concentration: 1.0
has only substance units: false
name: Nicotinamide adenine dinucleotide phosphate
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
type: Species
is: HMDB00217
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:58349
is: C00006
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110022#_db15026b_8342_4d4a_8342_64a4722272d1
is: Q9UHI5
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:23428
name: SLC7A8
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN

metaR APOC LYS BTNP
fast: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110022#
kinetic law: MODEL1310110022#
name: proteolysis of apoC-Lys-btn
type: Reaction
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110022#_e0da102a_42dd_4635_a03e_a6ed1378c3eb
is encoded by: hsa:FLJ44968
type: Species
initial concentration: NaN
name: _FLJ44968_1_m
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false

metaR r0340
is version of: http://identifiers.org/ec-code/1.3.1.38
is: SBO:0000176
reversible: false
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
product: MODEL1310110022#
kinetic law: MODEL1310110022#
fast: false
modifier: MODEL1310110022#
reactant: MODEL1310110022#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:

metaR r2122
product: MODEL1310110022#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110022#
is: SBO:0000185
reactant: MODEL1310110022#
reversible: true
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_a37f54f6_0750_4dc8_a182_4124a7469d6f
has only substance units: false
type: Species
constant: false
boundary condition: true
is: Q8IX04
initial concentration: NaN
is encoded by: hsa:55293
name: UEVLD
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_c21d82ae_0b5c_4bdd_844c_5d25034dd670
is encoded by: hsa:10948
has only substance units: false
type: Species
is: B4DUY1
name: STARD3
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true

metaR r2086
kinetic law: MODEL1310110022#
is: SBO:0000185
reactant: MODEL1310110022#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
product: MODEL1310110022#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110022#
fast: false

metaR r1600
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110022#
is: SBO:0000185
fast: false
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110022#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110022#_5dd913d9_debe_486f_bee4_c416aa696d4d
is encoded by: hsa:112724
name: RDH13
type: Species
is: B3KVA3
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false

metaM tdcoa c
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
name: Tetradecanoyl-CoA (n-C14:0CoA)
has only substance units: false
is: CHEBI:57385
is: HMDB01521
boundary condition: false
constant: false
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
is: C02593

metaM glx c
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
boundary condition: false
is: SBO:0000247
is: CHEBI:36655
type: Species
is: HMDB00119
has only substance units: false
constant: false
initial amount: NaN
name: glyoxylate
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110022#_63c83fef_5625_4e84_a70b_22a1caabfa22
name: AK4
is encoded by: hsa:205
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: P27144
has only substance units: false
type: Species
initial concentration: NaN

metaR SUCOAS1m
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.4
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
modifier: MODEL1310110022#
is described by: ECO:0000000
reactant: MODEL1310110022#
fast: false
name: Succinate--CoA ligase (GDP-forming)
is: SBO:0000176
type: Reaction
product: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_67435ede_d0ef_4b07_b8d3_9ba2176d9340
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
name: ACHE
boundary condition: true
constant: false
is encoded by: hsa:43

metaR APOCF
reversible: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110022#
type: Reaction
name: Apocarboxylase formation
fast: false
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10191093 NOTES:IT faked reaction to balance reaction in human biotin metabolism

http://identifiers.org/biomodels.db/MODEL1310110022#_2386711c_8e85_4530_afbc_2d31eb97232c
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: SLC35A1
type: Species
is: P78382
is encoded by: hsa:10559

metaM acgam c
initial amount: NaN
is: CHEBI:17411
has only substance units: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB00215
constant: false
name: N-acetyl-D-glucosamine
initial concentration: 1.0

metaM nadh x
initial concentration: 1.0
constant: false
is: CHEBI:57945
type: Species
is: C00004
has only substance units: false
name: Nicotinamide adenine dinucleotide - reduced
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB01487
is: http://identifiers.org/pubchem.compound/3306

metaM 4ppcys c
is: HMDB01117
is: CHEBI:59458
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
is: C04352
initial amount: NaN
type: Species
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352

http://identifiers.org/biomodels.db/MODEL1310110022#_34373b92_a6ad_4e7f_bb79_0267b1d18ef3
is: O43708
type: Species
is encoded by: hsa:2954
boundary condition: true
initial concentration: NaN
name: GSTZ1
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false

metaR r0130
reactant: MODEL1310110022#
is described by: ECO:0000000
kinetic law: MODEL1310110022#
type: Reaction
is: SBO:0000176
product: MODEL1310110022#
reversible: true
modifier: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4

metaR r2123
reversible: true
modifier: MODEL1310110022#
product: MODEL1310110022#
fast: false
kinetic law: MODEL1310110022#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110022#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110022#_26deab6f_750e_4d85_8cba_a2d103628fd1
initial concentration: NaN
name: _AA278423_1_m
is encoded by: hsa:AA278423
constant: false
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252

metaM guln c
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
name: L-gulonate
is: SBO:0000247
is: CHEBI:13115
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
is: HMDB03290
initial concentration: 1.0
constant: false

metaR r2085
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110022#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110022#
is: SBO:0000185
reversible: true
reactant: MODEL1310110022#

metaR r2198
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
reactant: MODEL1310110022#
modifier: MODEL1310110022#
reversible: true
product: MODEL1310110022#
fast: false
kinetic law: MODEL1310110022#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5

http://identifiers.org/biomodels.db/MODEL1310110022#_a1a3e368_c12f_4134_8f19_dea1f53eb104
type: Species
constant: false
is: P04745
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: AMY1B
is encoded by: hsa:277
has only substance units: false
boundary condition: true

metaR r0246
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
is: SBO:0000176
reactant: MODEL1310110022#
product: MODEL1310110022#
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
type: Reaction
kinetic law: MODEL1310110022#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.5.1.3
reversible: false

metaM succ m
initial concentration: 1.0
is: CHEBI:30031
has only substance units: false
constant: false
is: C00042
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
name: Succinate
is: HMDB00254

http://identifiers.org/biomodels.db/MODEL1310110022#_515d545b_b514_4c67_a6fc_5c9add808996
name: _BE042354_1_m
initial amount: NaN
constant: false
is encoded by: hsa:BE042354
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species

metaR r0009
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
reactant: MODEL1310110022#
product: MODEL1310110022#
modifier: MODEL1310110022#
type: Reaction
kinetic law: MODEL1310110022#
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.1.1
reversible: false
is: SBO:0000176

metaM dhlam m
boundary condition: false
initial concentration: 1.0
is: CHEBI:17694
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
type: Species
name: dihydrolipoamide
has only substance units: false
is: HMDB00985

http://identifiers.org/biomodels.db/MODEL1310110022#_0c1ecd26_ace2_4b9c_8013_755dc80eb271
has only substance units: false
constant: false
name: _AL525798_1_c
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:AL525798
initial concentration: NaN

metaR GMAND
is version of: http://identifiers.org/ec-code/4.2.1.47
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2762.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.2.1.47 Confidence Level: 0 AUTHORS: NOTES:JLR
modifier: MODEL1310110022#
reactant: MODEL1310110022#
product: MODEL1310110022#
type: Reaction
reversible: false
fast: false
name: GDP-D-mannose dehydratase
is: SBO:0000176
kinetic law: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_1eeedbb6_259f_4c79_86db_69518afb0116
constant: false
is: Q308M7
is encoded by: hsa:5169
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: ENPP3
boundary condition: true
initial amount: NaN
type: Species

metaM gal l
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB00143
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:12936
name: D-galactose
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124

http://identifiers.org/biomodels.db/MODEL1310110022#_dd9301e8_03f9_43c7_a132_df7b41a02199
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:276
is: SBO:0000252
boundary condition: true
is: Q6NSB3
has only substance units: false
name: AMY1A
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_1784c47f_1048_4e6c_ad10_9fcbe9f67aec
constant: false
type: Species
name: LDHAL6B
initial concentration: NaN
is: Q9BYZ2
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:92483
has only substance units: false

metaM xylu L c
is: CHEBI:17399
initial concentration: 1.0
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
boundary condition: false
name: L-xylulose
is: HMDB00751
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000247

metaM h2o2 c
is: HMDB03125
initial concentration: 1.0
has only substance units: false
is: C00027
constant: false
name: Hydrogen peroxide
is: CHEBI:16240
is: SBO:0000247
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
type: Species
initial amount: NaN
boundary condition: false

metaM arg L m
initial concentration: 1.0
type: Species
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: SBO:0000247
boundary condition: false
is: HMDB00517
constant: false
name: L-argininium(1+)
has only substance units: false
initial amount: NaN
is: CHEBI:32682

metaR r2088
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110022#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110022#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is: SBO:0000185
modifier: MODEL1310110022#
reactant: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_e9831c5a_66d5_4718_8c22_65cd1cc74863
initial concentration: NaN
type: Species
is encoded by: hsa:7296
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: TXNRD1

http://identifiers.org/biomodels.db/MODEL1310110022#_a78e2a0f_cb2a_4c77_bda0_9f3fd9fd2984
name: ALG5
constant: false
is: SBO:0000252
initial amount: NaN
is: Q9Y673
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:29880
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110022#_2eddd1a7_cfd2_4a9e_bb0f_3293fe5b8df6
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:55512
is: A8K0T6
boundary condition: true
initial amount: NaN
type: Species
name: SMPD3
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110022#_70fe22c5_051b_4d1d_aa3a_764735457756
initial concentration: NaN
initial amount: NaN
name: NOS1
has only substance units: false
type: Species
is: B4DG68
is encoded by: hsa:4842
boundary condition: true
is: SBO:0000252
constant: false

metaR ACONTm
fast: false
type: Reaction
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/4.2.1.3
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
name: Aconitate hydratase
product: MODEL1310110022#
modifier: MODEL1310110022#
reversible: true
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical
is: SBO:0000176

metaR r2124
fast: false
product: MODEL1310110022#
is: SBO:0000185
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
reversible: true
modifier: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000

metaM 4abutn m
initial concentration: 1.0
name: 4-ammoniobutanal
constant: false
is: CHEBI:58264
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
type: Species
initial amount: NaN
is: HMDB01080
boundary condition: false
is: SBO:0000247
has only substance units: false

metaR r1602
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110022#
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM acald m
is: SBO:0000247
has only substance units: false
name: acetaldehyde
initial concentration: 1.0
is: CHEBI:15343
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
is: HMDB00990
boundary condition: false
initial amount: NaN
constant: false
type: Species

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

metaR RE3568C
is described by: ECO:0000000
reversible: true
name: RE3568
is: SBO:0000176
product: MODEL1310110022#
fast: false
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
type: Reaction

metaM Rtotalcoa c
initial concentration: 1.0
constant: false
initial amount: NaN
name: R total Coenzyme A
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
is: CHEBI:16189
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB01448
has only substance units: false

metaR r0245
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.5.1.3
reversible: true
kinetic law: MODEL1310110022#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
type: Reaction
reactant: MODEL1310110022#
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
is described by: ECO:0000000
product: MODEL1310110022#

metaM ppbng c
boundary condition: false
has only substance units: false
notes: FORMULA: C10H13N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00588 EHMN_ABBREVIATION: C00931
is: HMDB00245
is: SBO:0000247
is: C00931
constant: false
initial concentration: 1.0
is: CHEBI:58126
type: Species
initial amount: NaN
name: Porphobilinogen

http://identifiers.org/biomodels.db/MODEL1310110022#_7e0f4c7a_d23f_4eae_85df_d8ee91d884f8
has only substance units: false
is encoded by: hsa:1349
initial concentration: NaN
is: P24311
boundary condition: true
type: Species
initial amount: NaN
name: COX7B
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110022#_16e1aa44_4495_41b5_ad66_b50b4477f1d7
name: NIT2
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is: Q9NQR4
is encoded by: hsa:56954
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110022#_1636307c_a944_4f6d_be3f_d238b770991a
is: SBO:0000252
is encoded by: hsa:AI291895
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: _AI291895_1_c
constant: false
boundary condition: true
type: Species

metaR HSD11B1r
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.146
fast: false
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (3290.2) or (3290.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.146 Confidence Level: 4 AUTHORS: PMID:11673786,PMID:15466942,PMID:7859916 NOTES:NJ
product: MODEL1310110022#
name: 11-beta-hydroxysteroid dehydrogenase type 1
is: SBO:0000176

metaR r2087
modifier: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110022#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is: SBO:0000185
reactant: MODEL1310110022#
reversible: true
kinetic law: MODEL1310110022#

metaR GLCt4
modifier: MODEL1310110022#
reactant: MODEL1310110022#
type: Reaction
product: MODEL1310110022#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110022#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
name: glucose transport via sodium symport

metaR r2125
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
fast: false
product: MODEL1310110022#
modifier: MODEL1310110022#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110022#
is described by: ECO:0000000
kinetic law: MODEL1310110022#

metaR r1591
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110022#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110022#

metaM cys L c
initial concentration: 1.0
boundary condition: false
name: L-cysteine
has only substance units: false
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:17561
constant: false
is: HMDB00574

metaR r2195
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
type: Reaction
product: MODEL1310110022#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
modifier: MODEL1310110022#
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM h2o2 e
initial amount: NaN
is: CHEBI:16240
is: SBO:0000247
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
initial concentration: 1.0
has only substance units: false
is: HMDB03125
constant: false
name: hydrogen peroxide
boundary condition: false
type: Species

metaM dhf m
is: CHEBI:57451
initial concentration: 1.0
is: HMDB01056
is: SBO:0000247
has only substance units: false
name: dihydrofolate(2-)
constant: false
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415

metaR S6TASE1ly
reversible: true
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is described by: ECO:0000000
type: Reaction
name: N-acetylglucosamine-6-sulfatase, lysosomal
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.1.6.14
reactant: MODEL1310110022#
is: SBO:0000176
modifier: MODEL1310110022#
product: MODEL1310110022#
fast: false

metaM succ c
is: CHEBI:30031
is: C00042
constant: false
name: Succinate
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00254
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042

http://identifiers.org/biomodels.db/MODEL1310110022#_c483be7d_43e9_4d02_a48d_c9eb8f7c88f4
initial concentration: NaN
is: SBO:0000252
name: _AA526438_1_m
is encoded by: hsa:AA526438
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false

metaR NDPK2
type: Reaction
name: nucleoside-diphosphate kinase (ATP:UDP)
is described by: ECO:0000269
modifier: MODEL1310110022#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110022#
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110022#
fast: false

metaM glyb e
initial concentration: 1.0
is: HMDB00043
has only substance units: false
name: glycine betaine
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
is: CHEBI:17750
constant: false
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110022#_60eb4f35_3f33_4464_a28c_12170c5eded3
name: RRM1
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
is: P23921
initial concentration: NaN
is encoded by: hsa:6240
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_f11885bd_7ce2_41c9_902c_1230cb830b51
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:91373
has only substance units: false
type: Species
name: UAP1L1
initial concentration: NaN
is: Q3KQV9
constant: false
boundary condition: true

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

metaR ATP2ter
reactant: MODEL1310110022#
reversible: true
name: AMP/ATP transporter, endoplasmic reticulum
product: MODEL1310110022#
fast: false
type: Reaction
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
is: SBO:0000185

metaR KHte
kinetic law: MODEL1310110022#
name: KHte
reactant: MODEL1310110022#
type: Reaction
reversible: true
product: MODEL1310110022#
is described by: ECO:0000134
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaM dcdp c
is: C00705
has only substance units: false
type: Species
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: CHEBI:58593
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB01245
name: dCDP
initial concentration: 1.0
constant: false

metaR LEUt5m
name: leucine mitochondrial transport
product: MODEL1310110022#
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
is described by: ECO:0000000
kinetic law: MODEL1310110022#
reversible: true

metaR r1603
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110022#
product: MODEL1310110022#
fast: false
kinetic law: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

metaR r2089
fast: false
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
kinetic law: MODEL1310110022#
is described by: ECO:0000000
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000185

metaR r0450
is version of: http://identifiers.org/ec-code/4.2.1.3
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
reversible: true
modifier: MODEL1310110022#
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
product: MODEL1310110022#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110022#
fast: false
reactant: MODEL1310110022#

metaR r1590
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110022#
is: SBO:0000185
reversible: true
product: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_8e9f3a04_3671_4c1f_b3d3_721de7558a38
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaR r2194
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110022#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
product: MODEL1310110022#
modifier: MODEL1310110022#
is: SBO:0000185
reactant: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_8c240b28_e634_41b6_bdb8_603ac6c2a838
has only substance units: false
boundary condition: true
is encoded by: hsa:279
is: P04746
initial concentration: NaN
is: SBO:0000252
name: AMY2A
type: Species
initial amount: NaN
constant: false

metaM 3odcoa m
is: CHEBI:28528
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: 3-Oxodecanoyl-CoA
is: HMDB03939
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_7e84c961_8ed7_47c6_83df_e44348e89a4b
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:4967
initial amount: NaN
name: OGDH
is: Q02218
is: SBO:0000252
type: Species
initial concentration: NaN

metaM dctp n
constant: false
name: dCTP
is: HMDB00998
is: CHEBI:16311
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
is: C00458
has only substance units: false
boundary condition: false
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458

metaR r0726
reactant: MODEL1310110022#
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.33
type: Reaction
is: SBO:0000176
product: MODEL1310110022#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:

metaM no c
boundary condition: false
is: C00533
initial amount: NaN
is: CHEBI:16480
is: SBO:0000247
constant: false
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
has only substance units: false
name: Nitric oxide
is: HMDB03378
initial concentration: 1.0
type: Species

metaR NCAMUP
is: SBO:0000185
is described by: ECO:0000000
name: Nicotinamide acid uptake
type: Reaction
kinetic law: MODEL1310110022#
reversible: false
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069599,PMID:1463467 NOTES:SAB mechanism copied from nac--not certain
fast: false
reactant: MODEL1310110022#

metaM gal e
name: D-Galactose
is: C00124
type: Species
is: HMDB00143
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0
boundary condition: false
is: CHEBI:0
constant: false
initial amount: NaN
has only substance units: false

metaR r0917
is described by: ECO:0000000
reactant: MODEL1310110022#
reversible: true
kinetic law: MODEL1310110022#
is: SBO:0000185
product: MODEL1310110022#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaM hs deg11 l
is: HMDB00868
type: Species
constant: false
notes: FORMULA: C55H81N3O67S7 CHARGE: -8
has only substance units: false
is: CHEBI:57737
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: heparan sulfate, degradation product 11

metaR NDPK1
modifier: MODEL1310110022#
name: nucleoside-diphosphate kinase (ATP:GDP)
kinetic law: MODEL1310110022#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110022#
reactant: MODEL1310110022#
type: Reaction
fast: false
is described by: ECO:0000134

metaR ALADGLYexR
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000304
fast: false
product: MODEL1310110022#
reversible: true
modifier: MODEL1310110022#
name: D-alanine/glycine reversible exchange
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
is: SBO:0000185

metaM Lpipecol x
name: L-pipecolic acid
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB00716
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H11NO2 CHARGE: 0 INCHI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1 EHMN_ABBREVIATION: C00408
is: CHEBI:30913
type: Species

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

metaM mlthf m
is: CHEBI:15636
name: 5,10-Methylenetetrahydrofolate
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
initial concentration: 1.0
is: HMDB01533
type: Species
constant: false
has only substance units: false
is: C00143
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaR r1604
product: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110022#
fast: false
is described by: ECO:0000000
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_c2a23f7e_7ac4_4cb3_8d46_c5b3f4dbe343
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: RRM2B
boundary condition: true
is: Q7LG56
constant: false
initial amount: NaN
is encoded by: hsa:50484
type: Species

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

metaR AMPtp
fast: false
reactant: MODEL1310110022#
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000185
product: MODEL1310110022#
name: AMP transporter, peroxisome
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ

metaM uri c
is: C00299
has only substance units: false
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
name: Uridine
constant: false
initial amount: NaN
is: HMDB00296
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16704
type: Species
boundary condition: false

metaR r0242
fast: false
is: SBO:0000176
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
reversible: true
product: MODEL1310110022#
modifier: MODEL1310110022#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/6.2.1.1

metaR r2197
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110022#
fast: false
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
is: SBO:0000185
modifier: MODEL1310110022#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110022#_2dd13e43_b680_4fbf_b1da_f9ce866cc75c
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:50
is: SBO:0000252
constant: false
type: Species
is: Q99798
name: ACO2
boundary condition: true

metaR r1593
product: MODEL1310110022#
fast: false
reversible: true
reactant: MODEL1310110022#
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaM cys L e
initial concentration: 1.0
boundary condition: false
name: L-cysteine
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:17561
constant: false
type: Species
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
is: HMDB00574

http://identifiers.org/biomodels.db/MODEL1310110022#_724c0d0c_addb_45c6_8a97_4de7e4fa252d
name: ALDH1B1
is encoded by: hsa:219
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
is: P30837
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_fbc2c5ea_3bfb_4cd2_bfb5_9393842ada68
constant: false
is: O75610
is: SBO:0000252
type: Species
is encoded by: hsa:10637
initial concentration: NaN
has only substance units: false
name: LEFTY1
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_37341ee1_c3c5_4fd6_b20d_f25feb4cb455
initial amount: NaN
is encoded by: hsa:1743
is encoded by: hsa:4967
has part: P09622
type: Species
has part: P36957
is encoded by: hsa:8050
constant: false
is encoded by: hsa:1738
has only substance units: false
name: DLD:DLST:OGDH:PDHX
has part: Q02218
boundary condition: true
is: SBO:0000297
initial concentration: NaN
has part: O00330

metaM glyb c
name: glycine betaine
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
is: CHEBI:17750
initial amount: NaN
is: HMDB00043

metaM hmbil c
name: Hydroxymethylbilane
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:57845
is: SBO:0000247
type: Species
notes: FORMULA: C40H38N4O17 CHARGE: -8 HEPATONET_1.0_ABBREVIATION: HC00628 EHMN_ABBREVIATION: C01024
is: HMDB01137
is: C01024
boundary condition: false
initial concentration: 1.0

metaR RE3346M
is: SBO:0000176
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110022#
name: RE3346
fast: false
notes: GENE_ASSOCIATION: (217.1) or (219.1) or (501.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
reactant: MODEL1310110022#
reversible: true
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110022#

metaR NDPK4
is described by: ECO:0000269
is: SBO:0000176
reversible: true
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110022#
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
type: Reaction
name: nucleoside-diphosphate kinase (ATP:dTDP)
fast: false

metaR GLYOp
is: SBO:0000176
fast: false
kinetic law: MODEL1310110022#
is described by: ECO:0000000
reversible: false
product: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9038835 NOTES:
type: Reaction
name: glycine oxidase, perixosomal

http://identifiers.org/biomodels.db/MODEL1310110022#_2991a735_4c14_42ea_a041_f1828beecad0
is encoded by: hsa:223
constant: false
has only substance units: false
initial concentration: NaN
is: P49189
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: ALDH9A1

metaM 6pgl r
is: SBO:0000247
is: CHEBI:57955
has only substance units: false
notes: FORMULA: C6H9O9P CHARGE: -2 INCHI: InChI=1S/C6H11O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-5,7-9H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00733 EHMN_ABBREVIATION: C01236
type: Species
initial concentration: 1.0
name: 6-O-phosphonato-D-glucono-1,5-lactone(2-)
initial amount: NaN
is: HMDB01127
constant: false
boundary condition: false

metaR r1605
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110022#
kinetic law: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000185
reactant: MODEL1310110022#

metaM nadh m
constant: false
is: CHEBI:57945
type: Species
name: Nicotinamide adenine dinucleotide - reduced
is: HMDB01487
is: http://identifiers.org/pubchem.compound/3306
boundary condition: false
initial amount: NaN
is: C00004
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaM ru5p D r
constant: false
is: HMDB00618
boundary condition: false
type: Species
is: CHEBI:58121
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
initial amount: NaN
name: D-ribulose 5-phosphate(2-)
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaM nadp c
is: HMDB00217
is: SBO:0000247
initial amount: NaN
type: Species
is: C00006
boundary condition: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: CHEBI:58349
constant: false
name: Nicotinamide adenine dinucleotide phosphate
has only substance units: false
initial concentration: 1.0

metaR r2196
kinetic law: MODEL1310110022#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110022#
modifier: MODEL1310110022#
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
type: Reaction
reactant: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_c06aadd9_3eb7_45bc_9d9a_54fd1bb2995f
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
name: VNN3
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:55350

metaR r1592
fast: false
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110022#
product: MODEL1310110022#
type: Reaction

metaR EX tsul LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiosulfate exchange
type: Reaction

metaM acglcgalgluside hs g
is: CHEBI:17103
notes: FORMULA: C38H69N2O17FULLRCO CHARGE: 0
name: N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_2f4fb80c_7a2c_4760_927a_5d9f10810e12
name: CLYBL
boundary condition: true
initial concentration: NaN
is: Q8N0X4
type: Species
is: SBO:0000252
is encoded by: hsa:171425
has only substance units: false
initial amount: NaN
constant: false

metaR LPS3e
reactant: MODEL1310110022#
product: MODEL1310110022#
modifier: MODEL1310110022#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
name: lipase, extracellular
is version of: http://identifiers.org/ec-code/3.1.1.3
reversible: false
kinetic law: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.23 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:NJ

metaR ARACHDt2
kinetic law: MODEL1310110022#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110022#
fast: false
product: MODEL1310110022#
name: fatty acid transport via diffusion
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_c820cd75_3cba_48bf_b830_4bea0fb28d6a
is encoded by: hsa:125965
initial concentration: NaN
name: COX6B2
constant: false
is: Q6YFQ2
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252

metaM 3mob m
initial amount: NaN
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
has only substance units: false
boundary condition: false
constant: false
name: 3-methyl-2-oxobutanoate
is: CHEBI:11851
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB00019

metaR GALASE13ly
is: SBO:0000176
fast: false
modifier: MODEL1310110022#
reactant: MODEL1310110022#
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110022#
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
name: beta-galactosidase, lysosomal

metaR HGNTOR
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
modifier: MODEL1310110022#
name: Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.13.11.5
type: Reaction
notes: GENE_ASSOCIATION: (3081.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.5 Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110022#

metaR r0915
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
is described by: ECO:0000000
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110022#
reversible: true
reactant: MODEL1310110022#

metaR r1606
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110022#
product: MODEL1310110022#
is: SBO:0000185
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110022#

metaR NDPK3
reactant: MODEL1310110022#
is: SBO:0000176
fast: false
reversible: true
modifier: MODEL1310110022#
name: nucleoside-diphosphate kinase (ATP:CDP)
notes: GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110022#
kinetic law: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_9ecf7625_2e71_4de5_a648_9fb3874709c3
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:9377
is: P20674
constant: false
type: Species
initial amount: NaN
name: COX5A

http://identifiers.org/biomodels.db/MODEL1310110022#_29a36885_abf3_40c8_a464_5088605f1918
has only substance units: false
initial amount: NaN
name: NUDT12
is: Q9BQG2
is: SBO:0000252
boundary condition: true
is encoded by: hsa:83594
constant: false
initial concentration: NaN
type: Species

metaM mal L e
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
boundary condition: false
is: HMDB00156
name: (S)-malate(2-)
constant: false
initial concentration: 1.0
is: CHEBI:15589
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247

metaR MERCPLACCYSt
reactant: MODEL1310110022#
product: MODEL1310110022#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:excretion of 3-mercaptolactate-cysteine disulfide (PMID: 6945862) MM
kinetic law: MODEL1310110022#
fast: false
name: 3-mercaptolactate-cysteine disulfide transport, extracellular
is: SBO:0000185
reversible: false

metaM uri e
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB00296
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
is: CHEBI:16704
has only substance units: false
is: C00299
boundary condition: false
constant: false
name: Uridine

metaR RE1845C
name: RE1845
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.65
reactant: MODEL1310110022#
modifier: MODEL1310110022#
is: SBO:0000176
kinetic law: MODEL1310110022#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 4 h[c] from compEHMN reaction as they were not necessary
product: MODEL1310110022#
fast: false
reversible: true

metaM sph1p e
boundary condition: false
is: CHEBI:57939
has only substance units: false
type: Species
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
initial concentration: 1.0
is: HMDB01383
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
is: SBO:0000247
constant: false
initial amount: NaN

metaR NDPK7
kinetic law: MODEL1310110022#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
reversible: true
is described by: ECO:0000269
name: nucleoside-diphosphate kinase (ATP:dCDP)
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110022#
type: Reaction
product: MODEL1310110022#

metaM pail hs n
is: CHEBI:57880
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
type: Species
name: 1-phosphatidyl-1D-myo-inositol(1-)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110022#_e9d489da_6618_4bd5_8c12_1450a8179932
is: SBO:0000252
is encoded by: hsa:6567
type: Species
boundary condition: true
has only substance units: false
name: SLC16A2
is: P36021
initial amount: NaN
constant: false
initial concentration: NaN

metaR r1595
is described by: ECO:0000000
product: MODEL1310110022#
kinetic law: MODEL1310110022#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
reactant: MODEL1310110022#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110022#_e5fb0817_af6f_43ae_b918_e529b9fc4f02
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: SLC23A2
type: Species
initial concentration: NaN
is encoded by: hsa:9962
constant: false

metaM gthrd r
is: SBO:0000247
initial concentration: 1.0
is: HMDB00125
constant: false
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
boundary condition: false
initial amount: NaN
name: glutathionate(1-)
is: CHEBI:57925
has only substance units: false
type: Species

metaR DURAD2
name: dihydrothymin dehydrogenase (NADP)
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.3.1.2
reversible: true
product: MODEL1310110022#
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
kinetic law: MODEL1310110022#
fast: false
type: Reaction
is described by: ECO:0000269
is: SBO:0000176

metaR CHOLt4
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD
kinetic law: MODEL1310110022#
fast: false
type: Reaction
is: SBO:0000185
modifier: MODEL1310110022#
product: MODEL1310110022#
is described by: ECO:0000269
reversible: true
name: choline, sodium cotransport

metaR r0139
kinetic law: MODEL1310110022#
is described by: ECO:0000000
modifier: MODEL1310110022#
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.3.2.2
product: MODEL1310110022#
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
is: SBO:0000176
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110022#_6a092fef_201d_4437_8b7b_83ccf7c057fc
has only substance units: false
boundary condition: true
name: NMRK1
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:54981
initial concentration: NaN
type: Species
constant: false
is: Q9NWW6

metaR THRGLNexR
kinetic law: MODEL1310110022#
name: L-threonine/glycine reversible exchange
is: SBO:0000185
modifier: MODEL1310110022#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false
reversible: true
product: MODEL1310110022#
type: Reaction
reactant: MODEL1310110022#

metaR r1607
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110022#
is: SBO:0000185
product: MODEL1310110022#
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110022#

metaR N4Tg
is: SBO:0000176
product: MODEL1310110022#
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: O-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
is described by: ECO:0000000
name: N-acetylgalactosamine 4-beta-galactosyltransferase, Golgi apparatus
type: Reaction

metaR PIt7
reactant: MODEL1310110022#
modifier: MODEL1310110022#
name: phosphate transport in/out via three Na+ symporter
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
is: SBO:0000185
reversible: true
is described by: ECO:0000269
product: MODEL1310110022#
fast: false
type: Reaction

metaM dnad c
is: SBO:0000247
is: CHEBI:18304
has only substance units: false
boundary condition: false
type: Species
is: C00857
initial concentration: 1.0
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
initial amount: NaN
name: Deamino-NAD+
constant: false
is: HMDB01179

metaR NDPK6
modifier: MODEL1310110022#
name: Nucleoside-diphosphate kinase (ATP:dUDP)
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
reversible: true
product: MODEL1310110022#
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false

metaR GGT5r
is described by: ECO:0000134
type: Reaction
fast: false
name: Gamma-glutamyltransferase 5
product: MODEL1310110022#
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (2687.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:18357468,PMID:18357469,PMID:6120203 NOTES:Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). NJ
reactant: MODEL1310110022#
modifier: MODEL1310110022#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.3.2.2

http://identifiers.org/biomodels.db/MODEL1310110022#_a9368c34_36f9_4517_a329_2a3ef33e63b5
type: Species
initial amount: NaN
is: SBO:0000252
name: LPL
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:4023
is: P06858

metaR r1594
product: MODEL1310110022#
kinetic law: MODEL1310110022#
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_6f115b08_a2d0_4507_adf2_1a7d34013944
is encoded by: hsa:3242
name: HPD
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is: B3KQ63
initial amount: NaN

metaM 5adtststerone c
name: 17beta-hydroxy-5alpha-androstan-3-one
initial concentration: 1.0
boundary condition: false
is: HMDB02961
constant: false
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
is: CHEBI:16330
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaM arg L c
type: Species
name: L-argininium(1+)
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: HMDB00517
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:32682

metaM crn x
has only substance units: false
is: HMDB00062
is: SBO:0000247
is: C00318
type: Species
initial concentration: 1.0
is: CHEBI:16347
constant: false
name: L-Carnitine
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
boundary condition: false
initial amount: NaN

metaM acald c
name: acetaldehyde
has only substance units: false
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
boundary condition: false
initial concentration: 1.0
is: CHEBI:15343
is: HMDB00990
is: SBO:0000247

metaR NDPK5
product: MODEL1310110022#
reactant: MODEL1310110022#
modifier: MODEL1310110022#
fast: false
name: Nucleoside-diphosphate kinase (ATP:dGDP)
is: SBO:0000176
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110022#

metaR r0913
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110022#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
kinetic law: MODEL1310110022#
is: SBO:0000185
reactant: MODEL1310110022#
type: Reaction

metaR r1608
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110022#
is: SBO:0000185
fast: false
product: MODEL1310110022#
reversible: true
kinetic law: MODEL1310110022#
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR PIt8
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
is described by: ECO:0000006
is: SBO:0000185
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
product: MODEL1310110022#
type: Reaction
fast: false
name: phosphate transport in/out via Na+ symporter
reversible: true

metaR COt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
kinetic law: MODEL1310110022#
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110022#
product: MODEL1310110022#
name: CO transporter via diffusion

metaM sph1p c
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:57939
type: Species
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
initial concentration: 1.0
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
is: HMDB01383
boundary condition: false
has only substance units: false

metaM glc D r
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:4167
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
name: D-glucose
constant: false
type: Species
is: HMDB00122
boundary condition: false

metaR NDPK9
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
fast: false
kinetic law: MODEL1310110022#
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110022#
name: nucleoside-diphosphate kinase (ATP:IDP)
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
is: SBO:0000176
modifier: MODEL1310110022#

metaM zym int2 r
boundary condition: false
initial amount: NaN
constant: false
name: zymosterol intermediate 2
initial concentration: 1.0
has only substance units: false
is: CHEBI:52386
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-20,23-24H,6,8-17H2,1-5H3/t19-,20+,23-,24+,26+,27-/m1/s1
is: SBO:0000247
type: Species

metaR r2193
product: MODEL1310110022#
fast: false
type: Reaction
kinetic law: MODEL1310110022#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110022#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110022#

metaR GCHOLAtx
is described by: ECO:0000000
name: bile acid intracellular transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
type: Reaction
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
product: MODEL1310110022#
reversible: true
is: SBO:0000185

metaR r1597
is: SBO:0000185
product: MODEL1310110022#
type: Reaction
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110022#_e63bd91e_fb97_4716_baba_699bf0854c07
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
is: O95340
type: Species
is: SBO:0000252
is encoded by: hsa:9060
name: PAPSS2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_6fb45fcf_7523_4d25_a6cf_e57480433b57
is: P21399
is encoded by: hsa:48
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
name: ACO1
boundary condition: true

metaR ASPTA
is version of: http://identifiers.org/ec-code/2.6.1.1
reactant: MODEL1310110022#
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
type: Reaction
name: aspartate transaminase
product: MODEL1310110022#
kinetic law: MODEL1310110022#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110022#_9e0ee7fb_4394_450d_aa60_2d5a38881852
initial amount: NaN
name: ALPPL2
boundary condition: true
type: Species
constant: false
has only substance units: false
is encoded by: hsa:251
initial concentration: NaN
is: P10696
is: SBO:0000252

metaR r1609
kinetic law: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110022#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
product: MODEL1310110022#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM acmana r
type: Species
is: HMDB01129
initial concentration: 1.0
constant: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: N-acetyl-D-mannosamine
is: CHEBI:17122

http://identifiers.org/biomodels.db/MODEL1310110022#_1f6021c3_834e_4db7_b7aa_3c4fc22c761b
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
name: PPA2
is encoded by: hsa:27068
initial concentration: NaN

metaR NACHEX23ly
type: Reaction
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
fast: false
is described by: ECO:0000000
reversible: false

metaR NDPK8
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110022#
is: SBO:0000176
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.7.4.6
name: Nucleoside-diphosphate kinase (ATP:dADP)
reversible: true
product: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110022#

metaM damp c
constant: false
name: dAMP(2-)
has only substance units: false
boundary condition: false
type: Species
is: HMDB00905
is: CHEBI:58245
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaM bilglcur r
type: Species
constant: false
name: mono(glucosyluronic acid)bilirubin(2-)
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
is: CHEBI:57767
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaM nadh r
constant: false
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57945
type: Species
initial amount: NaN
name: NADH(2-)
is: HMDB01487
has only substance units: false

metaR r1596
is: SBO:0000185
product: MODEL1310110022#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110022#
fast: false
reactant: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110022#_5baf76fd_2f17_4734_bcfa_6f08a276e15d
has only substance units: false
name: _100128062_1_m
type: Species
is encoded by: hsa:100128062
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN

metaM 4ppcys m
initial concentration: 1.0
is: HMDB01117
constant: false
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
initial amount: NaN
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
has only substance units: false
is: CHEBI:59458
is: SBO:0000247
type: Species
boundary condition: false

metaR CLOHtex2
name: chloride transport via hydroxide countertransport (2:1)
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
is described by: ECO:0000304
product: MODEL1310110022#
fast: false
type: Reaction
modifier: MODEL1310110022#
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
reversible: false
is: SBO:0000185

metaR METLEUex
product: MODEL1310110022#
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
type: Reaction
is: SBO:0000185
name: Methionine/Leucine exchange (Met in)
notes: GENE_ASSOCIATION: (6520.1 and 8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
is described by: ECO:0000269
fast: false
reversible: false
modifier: MODEL1310110022#

metaR NRPPHRt4 2 r
fast: false
kinetic law: MODEL1310110022#
is: SBO:0000185
name: Norepinephrine reversible transport in via sodium symport (1:2)
reactant: MODEL1310110022#
product: MODEL1310110022#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
modifier: MODEL1310110022#
type: Reaction

metaM 3aib D m
constant: false
name: D-3-Amino-isobutanoate
initial concentration: 1.0
initial amount: NaN
is: C03265
has only substance units: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
type: Species
is: HMDB02299
boundary condition: false
is: SBO:0000247

metaR r0456
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.7.1.32
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
kinetic law: MODEL1310110022#
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
modifier: MODEL1310110022#
is: SBO:0000176
reversible: false
reactant: MODEL1310110022#

metaM arg L e
initial amount: NaN
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
name: L-argininium(1+)
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:32682
type: Species
is: HMDB00517

metaM dhf e
is: HMDB01056
type: Species
is: CHEBI:57451
constant: false
initial amount: NaN
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
name: dihydrofolate(2-)
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaR r0911
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110022#
name: Facilitated diffusion
is described by: ECO:0000000
reactant: MODEL1310110022#
fast: false
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:

metaR FAOXC101C8m
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C8)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_55fb974d_3b3a_4a6b_b02b_fad35e9862be
name: GMPR2
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:51292
type: Species
constant: false

metaM gal c
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: C00124
is: HMDB00143
is: SBO:0000247
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0
has only substance units: false
name: D-Galactose
is: CHEBI:0
constant: false

metaM no e
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
is: C00533
is: CHEBI:16480
is: SBO:0000247
type: Species
is: HMDB03378
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
has only substance units: false
name: Nitric oxide

metaM acald e
constant: false
initial amount: NaN
type: Species
name: acetaldehyde
has only substance units: false
is: HMDB00990
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
boundary condition: false
is: CHEBI:15343
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110022#_31ed1392_0d95_467e_908a_e38b612e70fa
type: Species
is: E5KSL6
constant: false
is encoded by: hsa:1716
is: SBO:0000252
name: DGUOK
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false

metaM Lkynr c
is: SBO:0000247
constant: false
boundary condition: false
name: L-kynurenine
is: CHEBI:16946
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
is: HMDB00684

metaM mercplac c
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C3H5O3S CHARGE: -1 INCHI: InChI=1/C3H6O3S/c4-2(1-7)3(5)6/h2,4,7H,1H2,(H,5,6) EHMN_ABBREVIATION: C05823
is: C05823
boundary condition: false
is: HMDB02127
has only substance units: false
name: 3-Mercaptolactate
type: Species
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/8118
constant: false

metaR FUCtly
type: Reaction
is: SBO:0000185
reversible: false
name: L-fucose efflux from lysosome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:
reactant: MODEL1310110022#
product: MODEL1310110022#
is described by: ECO:0000000
kinetic law: MODEL1310110022#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110022#_c8e8c145_48aa_4f02_9d58_3fb9f060f411
name: DHCR24
is: Q15392
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:1718

metaR 2DR1PP
kinetic law: MODEL1310110022#
is described by: ECO:0000000
type: Reaction
reversible: false
is: SBO:0000176
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.10 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
product: MODEL1310110022#
name: 2-deoxy-D-ribose 1-phosphate phosphorylase
fast: false

metaR ALAGLNexR
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false
product: MODEL1310110022#
reversible: true
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
name: L-alanine/glutamine reversible exchange
is described by: ECO:0000304
reactant: MODEL1310110022#
type: Reaction
is: SBO:0000185

metaM 2hb e
type: Species
initial concentration: 1.0
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
initial amount: NaN
constant: false
is: HMDB00008
boundary condition: false
is: CHEBI:1148
is: SBO:0000247
has only substance units: false
name: 2-Hydroxybutyrate

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

metaM 20ahchsterol m
type: Species
initial amount: NaN
is: CHEBI:1296
is: SBO:0000247
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500
has only substance units: false
is: HMDB06283
initial concentration: 1.0
name: 20-hydroxycholesterol
boundary condition: false
constant: false

metaR EX HC02206 LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin C1(1-) exchange
type: Reaction

metaM ksi deg33 l
type: Species
is: CHEBI:12936
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 33
is: HMDB00143
notes: FORMULA: C76H125N5O62S2 CHARGE: -2
is: SBO:0000247
has only substance units: false

metaR GGH 6DHFe
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.4.19.9
kinetic law: MODEL1310110022#
reversible: false
name: Gamma-glutamyl hydrolase (6DHF), extracellular
product: MODEL1310110022#
reactant: MODEL1310110022#
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is: SBO:0000176
type: Reaction

metaM nadh c
is: http://identifiers.org/pubchem.compound/3306
is: C00004
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
name: Nicotinamide adenine dinucleotide - reduced
is: CHEBI:57945
boundary condition: false
is: HMDB01487
constant: false

metaR r0509
type: Reaction
is: SBO:0000176
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: 1.3.5.1 Confidence Level: 0 AUTHORS: PMID:2843227 NOTES:
name: Succinate:ubiquinone oxidoreductase Citrate cycle (TCA cycle) EC:1.3.5.1
product: MODEL1310110022#
is described by: ECO:0000000
reversible: false
fast: false
kinetic law: MODEL1310110022#

metaR GLNS
is: SBO:0000176
reversible: false
modifier: MODEL1310110022#
name: glutamine synthetase
is version of: http://identifiers.org/ec-code/4.1.1.15
is described by: ECO:0000254
type: Reaction
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110022#
fast: false
product: MODEL1310110022#
reactant: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_793f0f6f_c5a4_4f0e_b365_76cc1e7c355a
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
name: INPP5A
is: Q14642
boundary condition: true
has only substance units: false
is encoded by: hsa:3632

http://identifiers.org/biomodels.db/MODEL1310110022#_4eed5091_549a_47ea_b814_438664a32761
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:50
boundary condition: true
name: ACO2
is: Q99798
type: Species
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_2f8703e3_2071_42a6_9a01_3a65930dbf42
is: SBO:0000252
initial concentration: NaN
constant: false
name: ATG9B
type: Species
has only substance units: false
is: Q674R7
initial amount: NaN
boundary condition: true
is encoded by: hsa:285973

metaM dgdp c
is: HMDB00960
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
name: dGDP
is: C00361
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:58595

metaR CORE7GTg
notes: GENE_ASSOCIATION: SUBSYSTEM: O-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
is described by: ECO:0000000
kinetic law: MODEL1310110022#
reversible: false
name: Core 7 alpha-GalNAc-transferase, Golgi apparatus
product: MODEL1310110022#
fast: false
is: SBO:0000176
reactant: MODEL1310110022#
type: Reaction

metaR KCCt
reversible: true
fast: false
name: K+-Cl- cotransport
is described by: ECO:0000269
modifier: MODEL1310110022#
type: Reaction
reactant: MODEL1310110022#
is: SBO:0000185
product: MODEL1310110022#
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD

metaR HSAT1ly
type: Reaction
product: MODEL1310110022#
name: heparan-glucosaminide N-acetyltransferase, lysosomal
is described by: ECO:0000000
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
fast: false

metaM hs deg9 l
notes: FORMULA: C61H87N3O76S8 CHARGE: -10
initial concentration: 1.0
constant: false
is: HMDB06465
is: SBO:0000247
boundary condition: false
type: Species
name: heparan sulfate, degradation product 9
initial amount: NaN
has only substance units: false
is: CHEBI:27491

metaR MEVK1c
is version of: http://identifiers.org/ec-code/2.7.1.36
notes: GENE_ASSOCIATION: (4598.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book.
reactant: MODEL1310110022#
is described by: ECO:0000134
name: mevalonate kinase (atp) cytosol
product: MODEL1310110022#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
reversible: false
type: Reaction

metaR 3MOBte
reactant: MODEL1310110022#
is: SBO:0000185
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
type: Reaction
product: MODEL1310110022#
name: Transport of 3-methyl-2-oxobutanoate
reversible: true
kinetic law: MODEL1310110022#

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

metaM 4mlacac c
is: HMDB02052
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1- HEPATONET_1.0_ABBREVIATION: HC00635 EHMN_ABBREVIATION: C01036
is: SBO:0000247
boundary condition: false
name: 4-maleylacetoacetate
is: CHEBI:17105
constant: false

metaM 2hb c
constant: false
has only substance units: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
name: 2-Hydroxybutyrate
initial concentration: 1.0
is: SBO:0000247
is: HMDB00008
initial amount: NaN
type: Species
is: CHEBI:1148
boundary condition: false

metaR GALASE6ly
name: beta-galactosidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110022#
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
fast: false
reversible: false
product: MODEL1310110022#
kinetic law: MODEL1310110022#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_5a810ca9_bd86_4d96_8145_065b3b06d759
boundary condition: true
is: Q96G03
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: PGM2
is encoded by: hsa:55276
constant: false
initial amount: NaN
type: Species

metaM nicrnt c
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:57502
boundary condition: false
type: Species
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
name: Nicotinate D-ribonucleotide
has only substance units: false
is: C01185
is: HMDB01132

http://identifiers.org/biomodels.db/MODEL1310110022#_736ad383_2edd_484d_a49d_a6fa0b5efdf6
constant: false
is encoded by: hsa:4830
type: Species
boundary condition: true
has part: P22392
name: NME1:NME2
initial amount: NaN
is encoded by: hsa:4831
has part: P15531
initial concentration: NaN
has only substance units: false
is: SBO:0000297

metaR DTDPtn
reversible: true
is described by: ECO:0000000
product: MODEL1310110022#
kinetic law: MODEL1310110022#
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110022#
name: dTDP nuclear transport

http://identifiers.org/biomodels.db/MODEL1310110022#_408c7f21_5e69_4641_9836_f90d17b58fe0
name: SLCO4A1
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:28231
initial amount: NaN
constant: false
is: Q96BD0
has only substance units: false

metaR BTNt4i
reactant: MODEL1310110022#
name: Biotin uptake (antiport)
kinetic law: MODEL1310110022#
product: MODEL1310110022#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
is described by: ECO:0000269
reversible: false
type: Reaction
modifier: MODEL1310110022#

metaR r0651
is version of: http://identifiers.org/ec-code/1.5.1.2
type: Reaction
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
modifier: MODEL1310110022#
is described by: ECO:0000000
fast: false
product: MODEL1310110022#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110022#_0338c442_ea43_40fd_8d08_220a694cb339
has only substance units: false
initial amount: NaN
name: SMPD3
is encoded by: hsa:55512
is: SBO:0000252
is: Q9NY59
initial concentration: NaN
type: Species
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110022#_87a703e6_9013_40f6_b0ce_d020ad66cd9b
constant: false
is encoded by: hsa:2752
initial concentration: NaN
boundary condition: true
has only substance units: false
is: P15104
is: SBO:0000252
type: Species
name: GLUL
initial amount: NaN

metaM idour l
is: SBO:0000247
is: CHEBI:21338
constant: false
is: HMDB02704
type: Species
has only substance units: false
initial amount: NaN
name: L-iduronate
boundary condition: false
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
initial concentration: 1.0

metaM dtmp e
type: Species
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB01227
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
initial amount: NaN
is: SBO:0000247
name: dTMP(2-)
is: CHEBI:26999

http://identifiers.org/biomodels.db/MODEL1310110022#_144373d5_0f5d_403c_a04e_92042dd654de
has only substance units: false
is: SBO:0000252
constant: false
type: Species
is: Q9HC21
boundary condition: true
is encoded by: hsa:60386
name: SLC25A19
initial amount: NaN
initial concentration: NaN

metaR GLCNACASE4ly
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
reversible: false
modifier: MODEL1310110022#
name: alpha-N-acetylglucosaminidase, lysosomal
reactant: MODEL1310110022#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.50
kinetic law: MODEL1310110022#
is described by: ECO:0000000
product: MODEL1310110022#
type: Reaction

metaM tdchola x
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
is: CHEBI:9407
is: SBO:0000247
name: taurochenodeoxycholate
has only substance units: false
is: HMDB00951
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN

metaM 3mob e
is: HMDB00019
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
constant: false
initial concentration: 1.0
is: CHEBI:11851
type: Species
boundary condition: false
name: 3-methyl-2-oxobutanoate

metaR IDOURte
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110022#
fast: false
kinetic law: MODEL1310110022#
name: L-iduronate transport, extracellular
is described by: ECO:0000134
product: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_e0d2d9df_4084_43ac_930b_9e82bd13aea2
initial concentration: NaN
has part: A8K7W0
is encoded by: hsa:8875
name: VNN3:VNN2:VNN1
initial amount: NaN
is encoded by: hsa:55350
is: SBO:0000297
constant: false
has part: O95497
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:8876

metaR FUMTSULtm
kinetic law: MODEL1310110022#
fast: false
reactant: MODEL1310110022#
modifier: MODEL1310110022#
name: Fumarate:thiosulfate antiport, mitochondrial
is: SBO:0000185
type: Reaction
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reversible: true
is described by: ECO:0000269

metaR SQLEr
product: MODEL1310110022#
name: Squalene epoxidase, endoplasmic reticular (NADP)
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.132
notes: GENE_ASSOCIATION: (6713.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.99.7 Confidence Level: 4 AUTHORS: PMID:1964954 NOTES:NCD
reversible: false
modifier: MODEL1310110022#
is described by: ECO:0000134
kinetic law: MODEL1310110022#
type: Reaction
reactant: MODEL1310110022#
is: SBO:0000176

metaR EX ttdca LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecanoate (n-C14:0)
type: Reaction

metaR C14STRr
type: Reaction
name: C-14 sterol reductase
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
is version of: http://identifiers.org/ec-code/1.3.1.70
is described by: ECO:0000134
fast: false
modifier: MODEL1310110022#
is: SBO:0000176
reactant: MODEL1310110022#
product: MODEL1310110022#
reversible: false

metaM dttp e
boundary condition: false
initial amount: NaN
is: HMDB01342
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
type: Species
is: SBO:0000247
initial concentration: 1.0
name: dTTP(4-)
is: CHEBI:37568
constant: false
has only substance units: false

metaR RE3421R
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
fast: false
name: RE3421
reactant: MODEL1310110022#
type: Reaction
kinetic law: MODEL1310110022#
reversible: true
is described by: ECO:0000000
product: MODEL1310110022#
is: SBO:0000176

metaM 3snpyr c
has only substance units: false
notes: FORMULA: C3H2O5S CHARGE: -2 INCHI: InChI=1S/C3H4O5S/c4-2(3(5)6)1-9(7)8/h1H2,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C05527
boundary condition: false
initial amount: NaN
constant: false
is: HMDB02332
is: CHEBI:1665
initial concentration: 1.0
name: 3-Sulfinopyruvate
is: SBO:0000247
type: Species

metaR DCYTt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110022#
product: MODEL1310110022#
name: deoxycytidine transport via diffusion
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110022#

metaM ps hs m
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:18303
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial concentration: 1.0
name: ps_hs[m]
boundary condition: false

metaR r0504
fast: false
product: MODEL1310110022#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.3.10
is: SBO:0000176
reactant: MODEL1310110022#
modifier: MODEL1310110022#
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
kinetic law: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_033d6a82_e584_4800_aab6_42229125433d
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:H45672
name: _H45672_1_m

metaM hs deg19 l
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C43H67N2O42S2 CHARGE: -3
is: CHEBI:17180
initial amount: NaN
name: heparan sulfate, degradation product 19
type: Species
boundary condition: false
is: HMDB01352
is: SBO:0000247

metaM din c
is: C05512
boundary condition: false
is: HMDB00071
is: SBO:0000247
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
name: Deoxyinosine
initial concentration: 1.0
constant: false
is: CHEBI:28997
type: Species
has only substance units: false
initial amount: NaN

metaM cdp n
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB01546
name: CDP(3-)
constant: false
is: CHEBI:58069
boundary condition: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: SBO:0000247

metaR HSAT4ly
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reversible: false
reactant: MODEL1310110022#
is: SBO:0000185
type: Reaction
name: heparan-glucosaminide N-acetyltransferase, lysosomal

metaM crm hs r
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
constant: false
name: N-acylsphingosine
is: CHEBI:52639
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
initial amount: NaN
initial concentration: 1.0

metaR PEPCKm
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110022#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.1.1.32
fast: false
notes: GENE_ASSOCIATION: (5106.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.1.32 Confidence Level: 0 AUTHORS: PMID:8645161 NOTES:
product: MODEL1310110022#
modifier: MODEL1310110022#
name: Phosphoenolpyruvate carboxykinase (GTP)
reactant: MODEL1310110022#

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

metaR r0595
name: 3-Mercaptopyruvate:cyanide sulfurtransferase Cysteine metabolism EC:2.8.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 2.8.1.2 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:851908 NOTES:
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
reversible: false
product: MODEL1310110022#
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_68354a78_3fac_4d1b_9baf_c0d3ea8ecb05
type: Species
is encoded by: hsa:4722
initial concentration: NaN
name: NDUFS3
is: O75489
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false

metaM 2oxoadp c
name: 2-oxoadipate(2-)
boundary condition: false
type: Species
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:57499
is: HMDB00225
is: SBO:0000247
initial concentration: 1.0

metaR OCDCAtr
reversible: true
is described by: ECO:0000000
name: fatty acid transport via diffusion
product: MODEL1310110022#
type: Reaction
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
kinetic law: MODEL1310110022#
is: SBO:0000185

metaR r1961
reversible: false
product: MODEL1310110022#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110022#
modifier: MODEL1310110022#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110022#

metaM q10 m
is: CHEBI:46245
constant: false
is: HMDB01072
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
boundary condition: false
has only substance units: false
name: ubiquinone-10
initial amount: NaN

metaM pmtcrn c
boundary condition: false
is: CHEBI:17490
initial amount: NaN
is: HMDB00222
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
type: Species
initial concentration: 1.0
name: L-palmitoylcarnitine
constant: false
is: SBO:0000247
has only substance units: false

metaR S6TASE19ly
kinetic law: MODEL1310110022#
is: SBO:0000176
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
type: Reaction
reversible: true
is described by: ECO:0000000
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.1.6.14
name: N-acetylglucosamine-6-sulfatase, lysosomal
fast: false
reactant: MODEL1310110022#

metaM retinal cis 13 r
initial concentration: 1.0
constant: false
is: CHEBI:45487
name: 13-cis-retinal
boundary condition: false
is: HMDB06220
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
initial amount: NaN

metaR DNDPt15m
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110022#
name: dUDP transport via dGDP antiport
kinetic law: MODEL1310110022#
fast: false
is described by: ECO:0000269
product: MODEL1310110022#
is: SBO:0000185
reactant: MODEL1310110022#

metaM CE4872 c
is: SBO:0000247
is: CHEBI:15748
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
initial amount: NaN
constant: false
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
is: HMDB00127
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_b332f31a_2b8e_473c_a5cc_2687782b8919
is: SBO:0000252
has only substance units: false
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:AA854479
initial concentration: NaN
name: _AA854479_1_m
boundary condition: true

metaM datp n
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:61404
is: C00131
is: HMDB01532
name: dATP
type: Species
boundary condition: false
has only substance units: false

metaR GLUtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, needed to transport glu-L out of ER in conversion of leuktrC4-> leuktrD4 NJ
name: intracellular transport
is: SBO:0000185
product: MODEL1310110022#
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
fast: false
type: Reaction
is described by: ECO:0000000
reversible: true

metaM dttp c
is: CHEBI:37568
constant: false
initial amount: NaN
initial concentration: 1.0
is: C00459
is: HMDB01342
is: SBO:0000247
name: dTTP
has only substance units: false
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
type: Species
boundary condition: false

metaM mal L m
is: SBO:0000247
is: HMDB00156
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: CHEBI:15589
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
boundary condition: false
name: (S)-malate(2-)

metaR r0594
modifier: MODEL1310110022#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.3
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
reversible: true
kinetic law: MODEL1310110022#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
reactant: MODEL1310110022#
product: MODEL1310110022#
type: Reaction

metaR r0502
is version of: http://identifiers.org/ec-code/2.7.1.113
fast: false
product: MODEL1310110022#
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
kinetic law: MODEL1310110022#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110022#

metaR SERDGLYexR
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
type: Reaction
reversible: true
product: MODEL1310110022#
fast: false
is: SBO:0000185
reactant: MODEL1310110022#
name: D-Serine/Glycine reversible exchange

metaR EX 2hb LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Hydroxybutyrate exchange
type: Reaction

metaM din e
is: CHEBI:28997
name: Deoxyinosine
type: Species
is: HMDB00071
is: C05512
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false

metaR r0728
product: MODEL1310110022#
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000000
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
type: Reaction
is: SBO:0000176
reversible: true
fast: false

metaR CYTK7n
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110022#
is described by: ECO:0000269
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000176
fast: false
modifier: MODEL1310110022#
name: cytidylate kinase (CMP,UTP),nuclear

metaR OCDCEAtr
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110022#
name: fatty acid transport via diffusion
kinetic law: MODEL1310110022#
reversible: true
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110022#_929f188f_0a29_4778_89c8_a867f3748c1f
is: Q6FGV9
name: PMVK
is encoded by: hsa:10654
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
boundary condition: true
has only substance units: false

metaR LEUKTRD4t
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
is: SBO:0000185
name: leukotriene D4 transport
type: Reaction
fast: false
product: MODEL1310110022#
is described by: ECO:0000269
reversible: true

metaM acac m
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: HMDB00060
is: CHEBI:13705
has only substance units: false
initial amount: NaN
name: acetoacetate
type: Species

metaR SPMTDe
is: SBO:0000185
type: Reaction
name: SPMTDe
fast: false
kinetic law: MODEL1310110022#
is described by: ECO:0000134
reversible: true
reactant: MODEL1310110022#
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaM hs deg8 l
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C69H100N4O81S8 CHARGE: -10
is: SBO:0000247
constant: false
is: CHEBI:15748
is: HMDB00127
boundary condition: false
initial amount: NaN
name: heparan sulfate, degradation product 8

metaM gluside hs r
boundary condition: false
is: SBO:0000247
is: CHEBI:18368
initial amount: NaN
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
name: D-glucosyl-N-acylsphingosine
has only substance units: false
type: Species
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_14d4fe03_2330_4b28_8d28_badf6cbef916
initial concentration: NaN
is: Q8IXK2
boundary condition: true
constant: false
initial amount: NaN
name: GALNT12
is: SBO:0000252
is encoded by: hsa:79695
has only substance units: false
type: Species

metaM mescoa m
constant: false
has only substance units: false
name: Mesaconyl-CoA
initial amount: NaN
is: SBO:0000247
is: CHEBI:27969
initial concentration: 1.0
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
type: Species
is: C06028
boundary condition: false

metaR UMPK7n
name: UMP kinase (dGTP),nuclear
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110022#
product: MODEL1310110022#
modifier: MODEL1310110022#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
kinetic law: MODEL1310110022#
type: Reaction
reversible: true

metaR AATAi
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
reversible: false
is version of: http://identifiers.org/ec-code/2.6.1.7
is: SBO:0000176
product: MODEL1310110022#
type: Reaction
fast: false
is described by: ECO:0000269
reactant: MODEL1310110022#
name: 2-aminoadipate transaminase, irreversible
notes: GENE_ASSOCIATION: (51166.1) or (51166.2) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 4 AUTHORS: PMID:12126930 NOTES:MM

metaM HC00229 e
initial amount: NaN
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
is: SBO:0000247
name: Isomaltose
has only substance units: false
is: CHEBI:28189
boundary condition: false
type: Species
constant: false
initial concentration: 1.0

metaM HC01376 m
initial concentration: 1.0
is: CHEBI:28692
boundary condition: false
initial amount: NaN
constant: false
name: S-(2-Methylbutanoyl)-dihydrolipoamide
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-3-10(2)13(16)18-9-8-11(17)6-4-5-7-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05118
has only substance units: false
type: Species
is: SBO:0000247

metaR S6TASE26ly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reactant: MODEL1310110022#
reversible: true
fast: false
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
product: MODEL1310110022#
name: N-acetylglucosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.14
is: SBO:0000176
type: Reaction

metaM cyan m
constant: false
is: HMDB02084
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:18407
name: hydrogen cyanide
has only substance units: false
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
boundary condition: false

metaR RE3347C
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
kinetic law: MODEL1310110022#
reversible: true
is described by: ECO:0000000
name: RE3347
product: MODEL1310110022#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110022#

metaR EX etoh LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ethanol exchange
type: Reaction

metaR ILEt5m
is: SBO:0000185
reactant: MODEL1310110022#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
product: MODEL1310110022#
reversible: true
kinetic law: MODEL1310110022#
fast: false
name: Isoleucine mitochondrial transport

http://identifiers.org/biomodels.db/MODEL1310110022#_6ad3c897_d6cc_45b4_a0c6_d56dc31a9f8a
is encoded by: hsa:57468
name: SLC12A5
has only substance units: false
is: Q9H2X9
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN

metaR r0591
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
modifier: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
kinetic law: MODEL1310110022#
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
is: SBO:0000176
fast: false

metaR EX co LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Carbon monoxide exchange
type: Reaction

metaR Htx
name: H transporter, peroxisome
reversible: true
is: SBO:0000185
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
product: MODEL1310110022#
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ

http://identifiers.org/biomodels.db/MODEL1310110022#_b6a0789b_9693_4ccf_991c_9bc36feb6430
type: Species
boundary condition: true
initial amount: NaN
is: Q9BZV2
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:80704
name: SLC19A3
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_94de1e4c_1f00_4b49_8ca9_c30ac933b34e
has only substance units: false
boundary condition: true
is encoded by: hsa:4718
is: SBO:0000252
is: Q549M5
name: NDUFC2
type: Species
initial amount: NaN
initial concentration: NaN
constant: false

metaM 44mctr r
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB01023
is: SBO:0000247
type: Species
has only substance units: false
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
constant: false
is: CHEBI:17813

metaM HC02214 e
is: CHEBI:28852
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
name: prostaglandin-f1alpha
initial concentration: 1.0
initial amount: NaN
constant: false

metaR EX thf LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5,6,7,8-Tetrahydrofolate exchange
type: Reaction

metaR r0097
reactant: MODEL1310110022#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 6.2.1.1 Confidence Level: 0 AUTHORS: PMID:10843999,PMID:14086739,PMID:238571,PMID:2901103 NOTES:
name: Acetate:CoA ligase (AMP-forming) Pyruvate metabolism EC:6.2.1.1
reversible: false
fast: false
type: Reaction
product: MODEL1310110022#
kinetic law: MODEL1310110022#
is: SBO:0000176

metaR RE1845X
is: SBO:0000176
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
fast: false
is described by: ECO:0000000
name: RE1845
type: Reaction
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 1 h[c] from compEHMN reaction as they were not necessary
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.65
reactant: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_2e694674_cd15_4910_935f_a848005cc1e7
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AI915649
name: _AI915649_1_c
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species

metaM ksii core2 e
name: keratan sulfate II (core 2-linked)
initial concentration: 1.0
is: HMDB00211
has only substance units: false
boundary condition: false
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
constant: false
is: CHEBI:17268
is: SBO:0000247
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_bc62ee96_5e13_4b1e_b824_2a91ef501ee7
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
name: _AI091231_1_c
is encoded by: hsa:AI091231
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_2de4a8b6_d24d_47ad_87f3_01e2c65cfe7d
constant: false
is encoded by: hsa:570
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
name: BAAT
initial amount: NaN
is: Q14032

metaR r0590
is described by: ECO:0000000
fast: false
product: MODEL1310110022#
reversible: false
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
is: SBO:0000176
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
reactant: MODEL1310110022#
type: Reaction
modifier: MODEL1310110022#

metaR r2344
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110022#
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110022#_982462d9_a1cb_48a2_b117_a38b40b45964
is: SBO:0000252
type: Species
has only substance units: false
is: Q546H9
boundary condition: true
is encoded by: hsa:7915
initial amount: NaN
initial concentration: NaN
constant: false
name: ALDH5A1

http://identifiers.org/biomodels.db/MODEL1310110022#_2fd2cc37_1ea5_45b6_ba09_fe9e29f4f9d2
has only substance units: false
is encoded by: hsa:341947
initial amount: NaN
is: Q7Z4L0
type: Species
constant: false
initial concentration: NaN
name: COX8C
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110022#_eba1a700_cf85_4d46_9025_e9fa6d4447e5
type: Species
has only substance units: false
initial concentration: NaN
name: SLC7A10
is: Q9NS82
constant: false
is: SBO:0000252
is encoded by: hsa:56301
boundary condition: true
initial amount: NaN

metaM ppa c
name: propionate
is: SBO:0000247
initial amount: NaN
is: HMDB00237
type: Species
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
is: CHEBI:17272
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_9890a961_b9c8_49fd_8595_b3f464a8f182
type: Species
boundary condition: true
initial concentration: NaN
name: ESPN
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:83715
is: B1AK53

metaR NDPK10
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110022#
type: Reaction
name: nucleoside-diphosphate kinase (ATP:dIDP)
modifier: MODEL1310110022#
is: SBO:0000176
fast: false
is described by: ECO:0000134
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
kinetic law: MODEL1310110022#
reversible: true

metaR NACHEX25ly
kinetic law: MODEL1310110022#
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110022#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110022#
reversible: false
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false

metaR FRDPtc
product: MODEL1310110022#
kinetic law: MODEL1310110022#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
is described by: ECO:0000000
reactant: MODEL1310110022#
type: Reaction
reversible: true
name: lipid, flip-flop intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110022#_5f1485f6_9ec9_4d51_adab_66ead52540dc
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110022#_87e2d8de_4cde_4381_8490_502d245cfdb3
is: P36959
is: SBO:0000252
is encoded by: hsa:2766
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
name: GMPR

metaR MI13PP
fast: false
product: MODEL1310110022#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.64 Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
name: inositol-1,3-bisphosphate 3-phosphatase
is described by: ECO:0000000
kinetic law: MODEL1310110022#
is: SBO:0000176
reactant: MODEL1310110022#
type: Reaction

metaR S6TASE16ly
product: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.14
type: Reaction
kinetic law: MODEL1310110022#
name: N-acetylglucosamine-6-sulfatase, lysosomal
fast: false
modifier: MODEL1310110022#
reversible: true

metaR C4STMO1r
is described by: ECO:0000000
kinetic law: MODEL1310110022#
reversible: false
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (6307.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:EC 1.-.-.- NCD ER version NJ
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.13.72
product: MODEL1310110022#
is: SBO:0000176
fast: false
modifier: MODEL1310110022#
name: C-4 sterol methyl oxidase (4,4-dimethylzymosterol)

http://identifiers.org/biomodels.db/MODEL1310110022#_453663c9_ee6b_407a_ab21_25965dad0d3f
name: ALDOA
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:226
type: Species

metaM idour c
type: Species
name: L-iduronate
boundary condition: false
is: CHEBI:21338
initial concentration: 1.0
constant: false
is: HMDB02704
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1

metaM progly e
has only substance units: false
notes: FORMULA: C7H12N2O3 CHARGE: 0
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
name: L-Prolinylglycine
boundary condition: false
is: HMDB11178

metaR r2121
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110022#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110022#

metaR HACD1m
is: SBO:0000176
kinetic law: MODEL1310110022#
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
reactant: MODEL1310110022#
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
modifier: MODEL1310110022#

metaM ru5p D c
name: D-ribulose 5-phosphate(2-)
has only substance units: false
is: CHEBI:58121
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
is: HMDB00618
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_cf6f9984_a7ba_4054_9c17_a2a5b1d57cb8
is: P33121
boundary condition: true
name: ACSL1
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:2180

metaM pail hs c
type: Species
boundary condition: false
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol(1-)
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57880

http://identifiers.org/biomodels.db/MODEL1310110022#_cdd0bca1_6b6d_4ee5_a8b9_85189f9b2601
is: O15357
is encoded by: hsa:3636
initial concentration: NaN
name: INPPL1
constant: false
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN

metaM 3dhguln c
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-3,5,7-9,11H,1H2,(H,12,13)/p-1/t2-,3+,5-/m0/s1
has only substance units: false
initial concentration: 1.0
is: HMDB06334
constant: false
name: 3-dehydro-L-gulonate
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:57655

http://identifiers.org/biomodels.db/MODEL1310110022#_679d20d4_f681_4428_a521_5c7649e9f47a
boundary condition: true
constant: false
is: P37268
is encoded by: hsa:2222
type: Species
initial concentration: NaN
initial amount: NaN
name: FDFT1
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110022#_a0617bd8_1831_4079_9fa9_46c987227a79
name: _AA502753_1_m
type: Species
initial concentration: NaN
is encoded by: hsa:AA502753
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110022#_8327250c_1a41_411c_ab94_d86415430c08
initial amount: NaN
name: AK7
initial concentration: NaN
is encoded by: hsa:122481
is: SBO:0000252
constant: false
is: Q96M32
type: Species
has only substance units: false
boundary condition: true

metaR GALASE18ly
product: MODEL1310110022#
is described by: ECO:0000000
reversible: false
type: Reaction
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110022#
fast: false
is: SBO:0000176
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.2.1.23

metaR r2347
type: Reaction
product: MODEL1310110022#
fast: false
kinetic law: MODEL1310110022#
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
is: SBO:0000185
reactant: MODEL1310110022#
is described by: ECO:0000000

metaR NADtpu
is described by: ECO:0000000
is: SBO:0000185
name: NAD transporter, peroxisome
type: Reaction
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into peroxisome (to avoid loops w/ NAD/NADP) NJ
reversible: false
product: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_47922dd6_6d54_4748_9cd9_a026b06cd713
name: ADSL
initial concentration: NaN
is encoded by: hsa:158
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: P30566
type: Species
constant: false

metaR NACHEX20ly
reversible: false
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
product: MODEL1310110022#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110022#
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
is described by: ECO:0000000

metaR r2120
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110022#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110022#
type: Reaction
reversible: true
kinetic law: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_79e06bcc_d0ee_4738_a5ff_08b957482172
initial amount: NaN
has only substance units: false
is encoded by: hsa:224
is: P51648
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
type: Species
name: ALDH3A2

metaR H2Otly
product: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
kinetic law: MODEL1310110022#
fast: false
is described by: ECO:0000000
reversible: true
name: H2O transport, lysosomal
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110022#_001a11dc_bfd9_4263_a600_d7dacc73bf36
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:883
is: Q16773
constant: false
type: Species
has only substance units: false
initial concentration: NaN
name: CCBL1
boundary condition: true

metaM but c
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
is: HMDB00039
type: Species
boundary condition: false
is: CHEBI:17968
name: butyrate
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaM bamppald c
boundary condition: false
notes: FORMULA: C3H8NO CHARGE: 1 INCHI: InChI=1/C3H7NO/c4-2-1-3-5/h3H,1-2,4H2 EHMN_ABBREVIATION: C05665
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: beta-Aminopropion aldehyde
is: HMDB01106
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7975
type: Species
constant: false
is: C05665

metaM lpam m
has only substance units: false
is: HMDB00962
is: CHEBI:17460
boundary condition: false
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
type: Species
name: lipoamide
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN

metaR SMPD4
reactant: MODEL1310110022#
fast: false
reversible: false
kinetic law: MODEL1310110022#
type: Reaction
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ
name: sphingomyelinase
is: SBO:0000176
is described by: ECO:0000000

metaR UDPGLCAter
type: Reaction
product: MODEL1310110022#
modifier: MODEL1310110022#
fast: false
is: SBO:0000185
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
kinetic law: MODEL1310110022#
name: UDPGlcA endoplasmic reticulum transport via UMP antiport

metaR Ser Thrtg
is described by: ECO:0000269
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
reversible: true
product: MODEL1310110022#
reactant: MODEL1310110022#
name: Ser/Thr transport (from golgi to lysosome)
kinetic law: MODEL1310110022#
is: SBO:0000185

metaR r2346
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
product: MODEL1310110022#
fast: false
kinetic law: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_c0f2cf0a_f191_4569_ab89_5a5d458ef5c4
is encoded by: hsa:492
constant: false
initial amount: NaN
is: Q16720
has only substance units: false
is: SBO:0000252
name: ATP2B3
type: Species
initial concentration: NaN
boundary condition: true

metaM acgam r
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
initial amount: NaN
type: Species
is: CHEBI:17411
name: N-acetyl-D-glucosamine
has only substance units: false
is: HMDB00215
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110022#_ff3f6670_b27c_4401_ab3c_31f6a5c12f71
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
name: GSTZ1
has only substance units: false
boundary condition: true
is: A6NED0
is encoded by: hsa:2954
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_32fb3726_100d_497c_8a45_cb2e9cb9f911
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:2588
type: Species
is: P34059
name: GALNS

metaM idour e
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:21338
has only substance units: false
constant: false
is: HMDB02704
name: L-iduronate
boundary condition: false
is: SBO:0000247

metaM bilglcur e
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:57767
name: mono(glucosyluronic acid)bilirubin(2-)

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

metaR 5AOPtm
is: SBO:0000185
reversible: true
is described by: ECO:0000134
kinetic law: MODEL1310110022#
type: Reaction
fast: false
product: MODEL1310110022#
name: 5-Aminolevulinate mitochondrial transport
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10558864 NOTES:NCD. Delta-aminolevulinic acid is produced in mitochondria then converted to PBG in the cytoplasm. Could not find anything on the transporter itself.

metaR NRPPHRtu
type: Reaction
name: Norepinephrine uniport
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
product: MODEL1310110022#
modifier: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_001b1b1e_aa56_4e94_b153_a0aa80a02dc0
is encoded by: hsa:223
name: ALDH9A1
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is: P49189

metaR DM dsT antigen g
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dsT antigen(g)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_5f62f07b_8c00_43d6_8d87_4a2e80b5db11
initial concentration: NaN
name: AFMID
is: Q63HM1
initial amount: NaN
boundary condition: true
is encoded by: hsa:125061
is: SBO:0000252
has only substance units: false
type: Species
constant: false

metaR r2341
is described by: ECO:0000000
reactant: MODEL1310110022#
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110022#
name: Organic anion transporter 5 Utilized transport

metaM progly c
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
name: L-Prolinylglycine
initial amount: NaN
notes: FORMULA: C7H12N2O3 CHARGE: 0
is: HMDB11178

metaM ksii core2 deg3 l
initial amount: NaN
is: CHEBI:12936
boundary condition: false
has only substance units: false
is: HMDB00143
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C58H94N5O46S2X CHARGE: -2
name: keratan sulfate II (core 2-linked), degradation product 3
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_cbaa9505_ca8d_4d0b_90b3_572e227ae1d3
initial amount: NaN
constant: false
type: Species
is: P50747
boundary condition: true
name: HLCS
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3141
initial concentration: NaN

metaM ksi deg13 l
is: CHEBI:57455
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C174H280N12O150S8 CHARGE: -8
is: HMDB01354
is: SBO:0000247
name: keratan sulfate I, degradation product 13
has only substance units: false

metaM acgalfucgalacglcgalgluside hs g
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: Type IA glycolipid
is: CHEBI:57847
type: Species
notes: FORMULA: C58H102N3O31FULLRCO CHARGE: 0
is: SBO:0000247
is: HMDB00304
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110022#_c47ec802_3fa9_4948_89a0_a4b843ce2e86
name: PGK2
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5232
initial concentration: NaN
is: P07205
type: Species
constant: false
has only substance units: false

metaM ps hs e
has only substance units: false
is: CHEBI:18303
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
name: phosphatidylserine
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110022#_9fc9fd27_3ae3_4766_a5f7_70179941747b
is encoded by: hsa:56301
has part: P08195
name: SLC7A10:SLC3A2
boundary condition: true
initial amount: NaN
initial concentration: NaN
has part: Q9NS82
constant: false
is encoded by: hsa:6520
type: Species
is: SBO:0000297
has only substance units: false

metaR r2090
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
product: MODEL1310110022#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110022#_c0b3c2fc_529e_48ce_911b_1461c07d88c3
boundary condition: true
constant: false
has only substance units: false
name: ALDH1A3
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:220
is: P47895
type: Species

metaR ALADGLNexR
fast: false
name: L-alanine/glutamine reversible exchange
modifier: MODEL1310110022#
type: Reaction
is: SBO:0000185
reversible: true
reactant: MODEL1310110022#
is described by: ECO:0000304
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110022#

metaM but e
boundary condition: false
name: butyrate
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:17968
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
initial amount: NaN
is: HMDB00039
constant: false

metaM pe hs r
boundary condition: false
constant: false
name: phosphatidylethanolamine
has only substance units: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:16038
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaR 13DAMPPOX
is described by: ECO:0000212
type: Reaction
kinetic law: MODEL1310110022#
reversible: false
reactant: MODEL1310110022#
product: MODEL1310110022#
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
is: SBO:0000176
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.4.3.21
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.22

metaM succ x
boundary condition: false
has only substance units: false
name: Succinate
is: C00042
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: HMDB00254
is: CHEBI:30031
constant: false
initial amount: NaN

metaR DM sTn antigen g
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM sTn antigen(g)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_db37179b_e2d3_4dd3_9c27_a91fc65dba8a
is encoded by: hsa:6528
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
name: SLC5A5
has only substance units: false
is: Q92911

metaM 6pgc r
name: 6-phosphonatooxy-D-gluconate
initial concentration: 1.0
is: CHEBI:58759
initial amount: NaN
is: HMDB01316
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H10O10P CHARGE: -3 INCHI: InChI=1S/C6H13O10P/c7-2(1-16-17(13,14)15)3(8)4(9)5(10)6(11)12/h2-5,7-10H,1H2,(H,11,12)(H2,13,14,15)/p-3/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00292 EHMN_ABBREVIATION: C00345
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_05f60e2b_7fb2_4770_81ff_3f635e0245f1
is: SBO:0000252
boundary condition: true
is encoded by: hsa:55229
initial amount: NaN
is: Q9NVE7
name: PANK4
constant: false
type: Species
has only substance units: false
initial concentration: NaN

metaM bilglcur c
initial concentration: 1.0
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
name: mono(glucosyluronic acid)bilirubin(2-)
type: Species
is: CHEBI:57767

http://identifiers.org/biomodels.db/MODEL1310110022#_5bbbacc1_1d8a_4735_8c01_1ff3400b739b
initial amount: NaN
is encoded by: hsa:4830
boundary condition: true
name: NME1
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR CYSSNAT5tc
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR r1147
reactant: MODEL1310110022#
product: MODEL1310110022#
fast: false
kinetic law: MODEL1310110022#
type: Reaction
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

metaM acgam l
boundary condition: false
is: SBO:0000247
is: CHEBI:17411
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
initial amount: NaN
is: HMDB00215
type: Species
initial concentration: 1.0
has only substance units: false
name: N-acetyl-D-glucosamine
constant: false

metaM 3mob c
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:11851
name: 3-methyl-2-oxobutanoate
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
is: HMDB00019
initial amount: NaN
has only substance units: false

metaM cdp e
is: CHEBI:58069
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB01546
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
name: CDP(3-)

metaM HC02214 c
is: CHEBI:28852
type: Species
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: prostaglandin-f1alpha

metaM 44mzym r
is: CHEBI:18364
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB01286
constant: false
initial concentration: 1.0
boundary condition: false
name: 14-demethyllanosterol
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_469aee9d_1577_42df_a9ab_ed1a1004623a
boundary condition: true
initial concentration: NaN
name: _AA664770_1_m
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:AA664770
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_aacf5084_ce62_4972_99f2_a7677acaa8fe
has only substance units: false
is encoded by: hsa:23428
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: SLC7A8
constant: false
type: Species
is: SBO:0000252
is: Q86U05

metaM 3m4hpga c
is: C05583
initial amount: NaN
boundary condition: false
notes: FORMULA: C9H10O4 CHARGE: 0 INCHI: InChI=1/C9H10O4/c1-13-9-4-6(8(12)5-10)2-3-7(9)11/h2-5,8,11-12H,1H3 HEPATONET_1.0_ABBREVIATION: HC01520 EHMN_ABBREVIATION: C05583
constant: false
type: Species
is: HMDB04061
is: http://identifiers.org/pubchem.compound/7909
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR r2091
modifier: MODEL1310110022#
reactant: MODEL1310110022#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110022#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110022#
fast: false
is: SBO:0000185

metaR ICDHyrm
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.42
modifier: MODEL1310110022#
name: Isocitrate dehydrogenase (NADP+)
is: SBO:0000176
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
kinetic law: MODEL1310110022#
is described by: ECO:0000269
product: MODEL1310110022#
reactant: MODEL1310110022#
reversible: true

metaM 34dhpha c
is: SBO:0000247
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-2-1-5(3-7(6)10)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 EHMN_ABBREVIATION: C01161
name: (3,4-dihydroxyphenyl)acetate
is: HMDB01336
boundary condition: false
is: CHEBI:17612
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species

metaR Htr
type: Reaction
product: MODEL1310110022#
reactant: MODEL1310110022#
name: H transporter, endoplasmic reticulum
fast: false
reversible: true
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is: SBO:0000185
is described by: ECO:0000000

metaM paps c
initial amount: NaN
is: CHEBI:58339
constant: false
boundary condition: false
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
is: SBO:0000247
has only substance units: false
is: HMDB01134
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110022#_e646db13_469a_43de_a823_32f35b487895
is: SBO:0000252
initial concentration: NaN
is: P30520
initial amount: NaN
type: Species
constant: false
has only substance units: false
boundary condition: true
name: ADSS
is encoded by: hsa:159

metaR r0339
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.1.2.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.1.2.22
is: SBO:0000176
reversible: false
modifier: MODEL1310110022#
fast: false
product: MODEL1310110022#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.65

metaR BPNT
is version of: http://identifiers.org/ec-code/3.1.3.7
kinetic law: MODEL1310110022#
is: SBO:0000176
type: Reaction
reversible: false
reactant: MODEL1310110022#
modifier: MODEL1310110022#
name: 3',5'-bisphosphate nucleotidase
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
product: MODEL1310110022#

metaM crm hs g
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
name: N-acylsphingosine
boundary condition: false
is: SBO:0000247
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
is: CHEBI:52639

http://identifiers.org/biomodels.db/MODEL1310110022#_64252e4d_1a30_419e_b1da_3236323fa785
initial concentration: NaN
type: Species
has only substance units: false
name: TM7SF2
is encoded by: hsa:7108
initial amount: NaN
is: O76062
boundary condition: true
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110022#_ab1d149b_6568_4ecb_8edf_a0af81ef285f
initial concentration: NaN
is encoded by: hsa:50814
initial amount: NaN
has only substance units: false
constant: false
is: Q15738
name: NSDHL
is: SBO:0000252
boundary condition: true
type: Species

metaM dcdp n
is: HMDB01245
constant: false
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
name: dCDP(3-)
initial amount: NaN
is: CHEBI:58593
boundary condition: false

metaR r2092
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110022#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110022#
reversible: true
is: SBO:0000185
reactant: MODEL1310110022#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110022#
fast: false

metaR BILGLCURtr
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
is: SBO:0000185
reversible: true
fast: false
name: glucuronidated compound transport
reactant: MODEL1310110022#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110022#

metaM ppa e
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
initial amount: NaN
is: HMDB00237
constant: false
name: propionate
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:17272
initial concentration: 1.0

metaR EX lac D LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-lactate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_cceca7ae_3739_4033_a430_e2c81d4b158b
has only substance units: false
name: PLCB2
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5330
type: Species
is: Q59F77

metaM cyan e
type: Species
name: hydrogen cyanide
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
is: CHEBI:18407
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB02084

metaM dctp c
name: dCTP
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: C00458
is: CHEBI:16311
is: HMDB00998

http://identifiers.org/biomodels.db/MODEL1310110022#_32316017_ddc1_473d_9e41_d9a81d60e577
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: FOLR1
is encoded by: hsa:2348
constant: false
has only substance units: false

metaR SUCCTD
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

metaR DITPtn
fast: false
product: MODEL1310110022#
name: dITP nuclear transport
reactant: MODEL1310110022#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: true
type: Reaction

metaR r2052
is described by: ECO:0000000
reactant: MODEL1310110022#
type: Reaction
modifier: MODEL1310110022#
fast: false
kinetic law: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: false
product: MODEL1310110022#

metaR r2112
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
modifier: MODEL1310110022#
fast: false
product: MODEL1310110022#
is described by: ECO:0000000
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185

metaM zymst r
initial amount: NaN
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437
type: Species
name: zymosterol
boundary condition: false
initial concentration: 1.0
is: HMDB06271
is: CHEBI:18252
constant: false
has only substance units: false
is: SBO:0000247

metaM 7dhchsterol r
initial concentration: 1.0
is: SBO:0000247
is: HMDB00032
name: cholesta-5,7-dien-3beta-ol
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
type: Species
has only substance units: false
is: CHEBI:17759
initial amount: NaN
constant: false
boundary condition: false

metaR r0483
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
kinetic law: MODEL1310110022#
type: Reaction
reactant: MODEL1310110022#
is: SBO:0000176
product: MODEL1310110022#
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:

metaR EX dad 2 LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 2-deoxyadenosine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_bf02a777_859a_47ba_a61a_605f966d0f0c
is: O95470
name: SGPL1
boundary condition: true
is: SBO:0000252
is encoded by: hsa:8879
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false

metaM lnlncg l
initial concentration: 1.0
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
name: gamma-linolenate
constant: false
boundary condition: false
is: CHEBI:32391
is: HMDB03073
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110022#_f5425f33_1b9c_475e_825c_4313db29839b
name: FDFT1
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2222
type: Species
constant: false
boundary condition: true
is: P37268

metaM prostge2 c
is: CHEBI:606564
is: HMDB01220
has only substance units: false
is: SBO:0000247
name: prostaglandin E2(1-)
constant: false
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
initial concentration: 1.0

metaM 4nph e
is: SBO:0000247
type: Species
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
is: HMDB01232
has only substance units: false
initial amount: NaN
name: 4-nitrophenolate
is: CHEBI:57917
boundary condition: false
constant: false
initial concentration: 1.0

metaM o2s m
constant: false
is: HMDB02168
is: CHEBI:18421
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: Superoxide anion
type: Species
is: C00704
has only substance units: false

MODEL1310110022#
species: metaM man1p c
species: metaM HC02203 c
species: metaM cit e
species: metaM CE2866 c
species: metaM dctp c
species: metaM 6a2ohxnt x
species: metaM so3 c
species: metaM CE5586 c
species: metaM 2hb e
species: metaM 2dr1p c
species: metaM C02528 c
species: metaM clpn hs c
species: metaM 13dpg c
species: metaM tsul c
species: metaM ppi r
stoichiometry: 0.352607
species: metaM Lkynr c
species: metaM glyc R c
species: metaM T antigen g
species: metaM gln L e
species: metaM 10fthf6glu c
species: metaM ditp c
species: metaM gluside hs c
species: metaM 4abut m
species: metaM ksi deg3 l
species: metaM o2s x
species: metaM cbasp c
species: metaM biocyt c
species: metaM orn m
species: metaM ksii core2 l
species: metaM cl e
species: metaM adp n
species: metaM HC00361 c
species: metaM 4mop e
species: metaM i e
species: metaM rib D c
species: metaM 3pg m
species: metaM hs deg3 l
species: metaM tdchola c
multipler: 2.77777777777778E-4
species: metaM gthrd c
species: metaM ksi deg20 l
species: metaM ura c
species: metaM co2 r
species: metaM progly c
species: metaM mev R c
species: metaM val L m
species: metaM ksi e
species: metaM cholp g
species: metaM datp c
species: metaM 4abut n
species: metaM cys L c
species: metaM tcynt e
species: metaM retn e
species: metaM acglcgalgluside hs g
species: metaM gchola e
species: metaM met L e
species: metaM hco3 c
species: metaM mi14p c
species: metaM malthx e
species: metaM idp n
species: metaM Ser Gly Ala X Gly l
species: metaM gchola x
species: metaM ksi deg24 l
species: metaM uri e
species: metaM oaa c
species: metaM hs deg12 l
species: metaM ala L c
species: metaM akg c
species: metaM tdchola x
species: metaM dtdp m
species: metaM ksii core2 deg6 l
stoichiometry: 0.385872
species: metaM 2mpdhl m
species: metaM 7dhf e
species: metaM hgentis c
species: metaM cit c
stoichiometry: 0.538891
species: metaM prostgf2 c
species: metaM dadp n

http://identifiers.org/biomodels.db/MODEL1310110022#_65f4335d_6809_4e43_bf35_b7a7057b04a1
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

metaR r1637
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110022#
reversible: true
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110022#

metaR r1569
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
type: Reaction
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185
fast: false

metaM hspg e
constant: false
type: Species
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
is: SBO:0000247
is: HMDB00719
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:15699
name: heparan sulfate proteoglycan
initial concentration: 1.0

metaR L LACt4r
kinetic law: MODEL1310110022#
name: L-lactate reversible transport via sodium symport
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110022#
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
is: SBO:0000185

metaR PROSTGE2t2
product: MODEL1310110022#
is described by: ECO:0000269
reactant: MODEL1310110022#
is: SBO:0000185
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
fast: false
name: prostaglandin uniport
reversible: true
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
type: Reaction

metaR r0331
reversible: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500,PMID:8615641 NOTES:
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110022#
product: MODEL1310110022#
name: 5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#

metaR r2113
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110022#
reversible: true
type: Reaction
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
is: SBO:0000185
modifier: MODEL1310110022#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM pyr c
is: C00022
is: CHEBI:15361
has only substance units: false
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/3324
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB00243
is: SBO:0000247
notes: FORMULA: C3H3O3 CHARGE: -1
name: pyruvate

http://identifiers.org/biomodels.db/MODEL1310110022#_59029dad_f606_461a_9b06_2b2afe935bd2
has only substance units: false
is encoded by: hsa:5169
name: ENPP3
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
is: Q308M7
boundary condition: true

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_bdf7b1fa_eeb6_4b93_850a_a5cecc6664b6
name: NDUFB7
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:4713
is: P17568
boundary condition: true
is: SBO:0000252
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_8e3fee54_e6d5_492e_8f27_8cdc40d789d9
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:LOC728997
name: _LOC728997_1_c
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_22a6b285_954a_4b34_9fe4_337facc8584a
constant: false
is: Q8WUM9
initial concentration: NaN
type: Species
name: SLC20A1
initial amount: NaN
has only substance units: false
is encoded by: hsa:6574
boundary condition: true
is: SBO:0000252

metaR DOCOSDIACTD
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: excretion of docosanedioic acid
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_0b2d6456_9f51_4f0a_b850_00ccd210cf08
boundary condition: true
name: SLC4A5
is: SBO:0000252
is: Q9BY07
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:57835
constant: false
has only substance units: false

metaM HC00250 e
is: CHEBI:29919
constant: false
type: Species
has only substance units: false
name: hydrosulfide
boundary condition: false
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110022#_2ec9cf33_5973_4ce8_8067_4e591db83fd8
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3028
name: HSD17B10
is: Q99714
boundary condition: true

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

metaR S6TASE24ly
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reactant: MODEL1310110022#
is: SBO:0000176
product: MODEL1310110022#
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
is described by: ECO:0000000
type: Reaction
fast: false
name: N-acetylglucosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.14
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110022#_f2ba86fe_8ee5_4f40_acd7_6cee7a8fcfb4
type: Species
is: SBO:0000252
has only substance units: false
name: MVK
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
is: B2RDU6
is encoded by: hsa:4598

metaM pro L c
is: HMDB00162
is: SBO:0000247
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: CHEBI:17203
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: L-proline
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_55135bc3_bc44_4251_a2d1_de25e5f64bc5
name: CTSA
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5476
is: P10619
boundary condition: true
has only substance units: false

metaR r1638
reversible: true
fast: false
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR TRPt
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
is described by: ECO:0000269
type: Reaction
product: MODEL1310110022#
reactant: MODEL1310110022#
name: L-tryptophan transport
is: SBO:0000185
modifier: MODEL1310110022#
fast: false
reversible: true
kinetic law: MODEL1310110022#

metaR r0845
name: Drug/Metabolite Transporter (DMT) TCDB:2.A.7.12.7
fast: false
product: MODEL1310110022#
is: SBO:0000185
reactant: MODEL1310110022#
is described by: ECO:0000000
kinetic law: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12759756,PMID:17466261,PMID:9759482 NOTES:UGLCNACtg but different compartment
reversible: false

metaR FADtru
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
name: FAD transporter, endoplasmic reticulum
reversible: false
kinetic law: MODEL1310110022#
product: MODEL1310110022#
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110022#_eac8bf80_e172_4b5d_924e_98748226d6aa
boundary condition: true
name: _R33828_1_c
is: SBO:0000252
is encoded by: hsa:R33828
has only substance units: false
constant: false
type: Species
initial amount: NaN
initial concentration: NaN

metaR r1568
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110022#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110022#
reversible: true
fast: false

metaR H2Otg
fast: false
reactant: MODEL1310110022#
is described by: ECO:0000000
name: H2O transport, Golgi apparatus
reversible: true
product: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110022#

metaM h2o r
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
name: H2O
type: Species
boundary condition: false
constant: false
is: HMDB02111
is: SBO:0000247
is: CHEBI:15377
is: C00001

http://identifiers.org/biomodels.db/MODEL1310110022#_d5510d77_6aef_4743_8e1c_dca1c50a5fae
initial amount: NaN
is encoded by: hsa:131
is: P40394
name: ADH7
boundary condition: true
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
has only substance units: false

metaR r2110
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110022#
product: MODEL1310110022#
reversible: true
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110022#
is described by: ECO:0000000
kinetic law: MODEL1310110022#

metaR ADKd
reactant: MODEL1310110022#
name: adenylate kinase (d form)
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)
is described by: ECO:0000269
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
product: MODEL1310110022#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.3
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110022#_c254b2dd_b38d_406a_bce5_5e106fddaf91
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2589
has only substance units: false
name: GALNT1
initial amount: NaN
boundary condition: true
constant: false
is: Q10472

metaM prostge2 e
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: prostaglandin E2(1-)
initial amount: NaN
is: CHEBI:606564
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
is: HMDB01220
is: SBO:0000247
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_314219ad_11db_4ebc_8e5c_102e7c32f1bd
type: Species
is: Q8N695
boundary condition: true
is: SBO:0000252
is encoded by: hsa:160728
initial concentration: NaN
name: SLC5A8
initial amount: NaN
has only substance units: false
constant: false

metaR r0908
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110022#
fast: false
type: Reaction
product: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000185

metaR r1567
reversible: true
product: MODEL1310110022#
kinetic law: MODEL1310110022#
type: Reaction
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110022#
is: SBO:0000185

metaR RE3326M
fast: false
is version of: http://identifiers.org/ec-code/1.2.4.4
reactant: MODEL1310110022#
reversible: true
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:2699399,PMID:9665099 NOTES:
is described by: ECO:0000000
name: RE3326
is: SBO:0000176
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
type: Reaction

metaR r1635
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110022#
kinetic law: MODEL1310110022#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110022#
modifier: MODEL1310110022#
type: Reaction

metaR GLYt7 311 r
reactant: MODEL1310110022#
is described by: ECO:0000006
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
modifier: MODEL1310110022#
type: Reaction
is: SBO:0000185
name: glycine reversible transport via sodium and chloride symport (3:1:1)
fast: false
kinetic law: MODEL1310110022#
reversible: true

metaM 5fthf m
name: 5-formyltetrahydrofolate(2-)
has only substance units: false
boundary condition: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
constant: false
is: CHEBI:57457
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB01562

metaR r2111
fast: false
product: MODEL1310110022#
reversible: true
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110022#
is: SBO:0000185
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110022#_f09dd0a9_fe80_40bc_8929_91446d34185c
boundary condition: true
is: Q9Y227
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:9583
constant: false
initial amount: NaN
name: ENTPD4

metaM pyr e
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:15361
initial amount: NaN
initial concentration: 1.0
constant: false
name: pyruvate
type: Species
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: HMDB00243

metaR EX 9 cis retfa LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid 9-cis-retinol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_34c35f63_5d86_4984_8ac5_0c95b4f650d4
is: O60331
has only substance units: false
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:23396
boundary condition: true
name: PIP5K1C
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_6c8a9e95_81c1_4ee8_9736_216b6510e6a3
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:57127
type: Species
is: Q9H310
is: SBO:0000252
has only substance units: false
name: RHBG
initial amount: NaN

metaR ALDD2xm
modifier: MODEL1310110022#
type: Reaction
kinetic law: MODEL1310110022#
fast: false
reversible: false
is: SBO:0000176
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000134
name: aldehyde dehydrogenase (acetylaldehyde, NAD), mitochondrial
notes: GENE_ASSOCIATION: (219.1) or (217.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:18983992,PMID:18983993,PMID:19382904,PMID:19382905 NOTES:NCD. For NAD
reactant: MODEL1310110022#

metaR r0909
name: Transport reaction
product: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
is described by: ECO:0000000
reversible: true

metaR r1566
reactant: MODEL1310110022#
is: SBO:0000185
type: Reaction
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110022#
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

metaR TSULt4 3
is described by: ECO:0000269
fast: false
type: Reaction
name: thiosulfate transport via sodium symport
reactant: MODEL1310110022#
reversible: true
kinetic law: MODEL1310110022#
is: SBO:0000185
product: MODEL1310110022#
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (6561.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10811962,PMID:11161786 NOTES:NCD

metaM pro L e
is: HMDB00162
is: CHEBI:17203
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
initial concentration: 1.0
constant: false
boundary condition: false
name: L-proline
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247

metaR r1636
is described by: ECO:0000000
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110022#
is: SBO:0000185
product: MODEL1310110022#
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110022#

metaM hs deg3 l
is: HMDB00127
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C81H117N5O97S10 CHARGE: -12
is: CHEBI:15748
initial concentration: 1.0
name: heparan sulfate, degradation product 3
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_69e7295a_db8e_474d_97a5_e2e9b1ae04f4
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
name: OGDH
has only substance units: false
type: Species
is encoded by: hsa:4967
is: B4E3E9
boundary condition: true

metaR ALAtN1
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
kinetic law: MODEL1310110022#
name: Alanine transport (Na, H coupled)
type: Reaction
fast: false
product: MODEL1310110022#
reversible: true
is: SBO:0000185
modifier: MODEL1310110022#
reactant: MODEL1310110022#

metaM ppcoa c
name: Propanoyl-CoA
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01275
type: Species
is: C00100
boundary condition: false
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: CHEBI:57392
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110022#_d4aefe3f_8666_4163_949c_4ec83c92f648
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: INPP5D
is encoded by: hsa:3635
has only substance units: false
constant: false
type: Species
is: Q92835

http://identifiers.org/biomodels.db/MODEL1310110022#_8440be8b_28bb_44d7_902f_bbbacf821a41
constant: false
name: _AI440329_1_r
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AI440329
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false

metaR r2116
product: MODEL1310110022#
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
reversible: true
is: SBO:0000185
modifier: MODEL1310110022#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
type: Reaction

metaM h2o x
is: SBO:0000247
is: HMDB02111
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:15377
is: C00001
initial amount: NaN
type: Species
initial concentration: 1.0
name: H2O

metaR r0842
is: SBO:0000185
kinetic law: MODEL1310110022#
fast: false
product: MODEL1310110022#
is described by: ECO:0000000
name: Postulated transport reaction
reactant: MODEL1310110022#
modifier: MODEL1310110022#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
is version of: http://identifiers.org/ec-code/1.3.1.72

metaR r1565
reversible: true
product: MODEL1310110022#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110022#
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110022#

metaR r1633
product: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110022#
type: Reaction

metaM HC00591 c
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
name: 2-oxoglutaramate
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:16769
initial amount: NaN

metaR TCHOLAte
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110022#
product: MODEL1310110022#
name: bile acid intracellular transport
fast: false

W3 CDTF: Fri Aug 31 05:41:38 BST 2012

metaR HISTAtu
modifier: MODEL1310110022#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
fast: false
kinetic law: MODEL1310110022#
reversible: true
product: MODEL1310110022#
type: Reaction
reactant: MODEL1310110022#
is: SBO:0000185
name: Histamine uniport

metaR r0480
type: Reaction
reactant: MODEL1310110022#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
kinetic law: MODEL1310110022#
product: MODEL1310110022#
is described by: ECO:0000000
fast: false
reversible: true

metaR r1791
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
product: MODEL1310110022#
name: Y+LAT2 Utilized transport
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110022#
reactant: MODEL1310110022#
type: Reaction
kinetic law: MODEL1310110022#

metaR FATP3t
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
name: fatty acid electroneutral transport
fast: false
product: MODEL1310110022#
reversible: true
modifier: MODEL1310110022#
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#

metaR r1564
kinetic law: MODEL1310110022#
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_3177a9b5_1634_4f5a_892b_33acdecdf42e
has only substance units: false
constant: false
is: SBO:0000252
name: GPI
is encoded by: hsa:2821
initial concentration: NaN
is: P06744
type: Species
boundary condition: true
initial amount: NaN

metaR r2117
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110022#
reactant: MODEL1310110022#
product: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_0037ccd2_bbfb_478c_8d87_72b9e3b7d1e4
constant: false
is: Q5SYN6
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: SLC22A3
is encoded by: hsa:6581

http://identifiers.org/biomodels.db/MODEL1310110022#_1dbaa3d1_81d7_48ef_ae62_fa20afa88034
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:51179
name: HAO2

metaM pmtcoa r
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:3454
name: Palmitoyl-CoA (n-C16:0CoA)
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
is: HMDB01338
is: C00154
initial amount: NaN
boundary condition: false
constant: false

metaR r1634
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110022#
reactant: MODEL1310110022#
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

metaM HC02180 c
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
is: SBO:0000247
constant: false
is: CHEBI:28728
name: thromboxane-b2
initial concentration: 1.0

metaR GLCNACASE2ly
name: alpha-N-acetylglucosaminidase, lysosomal
reactant: MODEL1310110022#
fast: false
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reversible: false
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
modifier: MODEL1310110022#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.50

metaR r1857
reactant: MODEL1310110022#
is described by: ECO:0000000
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110022#
fast: false
modifier: MODEL1310110022#
is: SBO:0000185
reversible: false
type: Reaction
name: Y+LAT2 Utilized transport

metaR r0841
product: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16756494 NOTES:
is described by: ECO:0000000
name: Free diffusion
modifier: MODEL1310110022#
is: SBO:0000185
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.271
type: Reaction
kinetic law: MODEL1310110022#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110022#_49ebd270_e79e_411e_b812_a6ac4fc34a29
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
is: P33316
name: DUT
is encoded by: hsa:1854

http://identifiers.org/biomodels.db/MODEL1310110022#_3b35f9b8_62dd_46b8_9f41_b0158bb06e23
is encoded by: hsa:549
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
name: AUH
initial concentration: NaN
has only substance units: false
constant: false
is: Q13825

metaM 2mbcoa m
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB01041
is: CHEBI:57336
name: 2-methylbutanoyl-CoA(4-)
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN

metaR UMPK
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
product: MODEL1310110022#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
name: UMP kinase
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110022#_3933820a_9449_4023_84b9_abf516bb7f9c
is: O95573
is encoded by: hsa:2181
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
name: ACSL3
boundary condition: true
has only substance units: false

metaR EX cytd LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Cytidine
type: Reaction

metaR r2114
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110022#
type: Reaction
fast: false
kinetic law: MODEL1310110022#
is described by: ECO:0000000
product: MODEL1310110022#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110022#

metaR r1563
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110022#
reversible: true
product: MODEL1310110022#
is described by: ECO:0000000
kinetic law: MODEL1310110022#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_edc8cb97_0a71_4648_ba65_abf89a19281b
boundary condition: true
initial amount: NaN
name: SLC17A5
has only substance units: false
initial concentration: NaN
is encoded by: hsa:26503
type: Species
is: Q9NRA2
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110022#_898d18d6_9374_44b3_ba30_c853954d4638
constant: false
is: SBO:0000252
name: _AW277253_1_c
boundary condition: true
is encoded by: hsa:AW277253
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

metaR G5SADrm
fast: false
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
type: Reaction
product: MODEL1310110022#
is: SBO:0000176
is described by: ECO:0000000
reversible: true
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD

metaM urate x
is: C00366
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:17775
has only substance units: false
constant: false
type: Species
is: HMDB00289
initial concentration: 1.0
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
name: Urate

metaR r1631
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110022#
reversible: true
fast: false
product: MODEL1310110022#

metaM itacon m
has only substance units: false
name: itaconate(2-)
type: Species
is: HMDB02092
is: CHEBI:17240
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
is: SBO:0000247

metaM phe L e
is: CHEBI:17295
name: L-phenylalanine
has only substance units: false
is: HMDB00159
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
initial concentration: 1.0
type: Species

metaR PI45P5Pn
reactant: MODEL1310110022#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 2 AUTHORS: PMID:12728269 NOTES:NCD
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase, nuclear
is: SBO:0000176
kinetic law: MODEL1310110022#
reversible: false
fast: false

metaM 3hibutcoa m
name: (S)-3-Hydroxyisobutyryl-CoA
has only substance units: false
boundary condition: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
is: HMDB01052
is: CHEBI:28259
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110022#_e339042b_b382_4864_b53a_dbdcecbfd560
boundary condition: true
type: Species
is: Q546Y9
has only substance units: false
is encoded by: hsa:57379
initial amount: NaN
name: AICDA
constant: false
initial concentration: NaN
is: SBO:0000252

metaR HSD11B2r
modifier: MODEL1310110022#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3291.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11673786,PMID:15466942,PMID:7859916 NOTES:NJ
product: MODEL1310110022#
kinetic law: MODEL1310110022#
reversible: true
name: 11-beta-hydroxysteroid dehydrogenase type 2
is version of: http://identifiers.org/ec-code/1.1.1.146
type: Reaction
fast: false
reactant: MODEL1310110022#
is described by: ECO:0000269

metaR EX galside hs LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-galactosyl-N-acylsphingosine exchange
type: Reaction

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

metaR r1562
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110022#
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_8af3127e_8257_4e5f_a283_8eac0b69a11a
is encoded by: hsa:AI222095
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: _AI222095_1_e
boundary condition: true

metaR DRPA
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
name: deoxyribose-phosphate aldolase
reactant: MODEL1310110022#
product: MODEL1310110022#
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110022#
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110022#_9e9c2c8d_9457_4a24_af1f_a38a0c0ebd61
initial amount: NaN
name: BCKDHB
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:594
is: P21953
has only substance units: false

metaR r1632
fast: false
is described by: ECO:0000000
product: MODEL1310110022#
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110022#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110022#

metaR AHCYStr
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110022#
fast: false
is described by: ECO:0000000
product: MODEL1310110022#
name: S-Adenosyl-L-homocysteine intracellular diffusion
is: SBO:0000185
reversible: true
reactant: MODEL1310110022#

metaR r2115
kinetic law: MODEL1310110022#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
modifier: MODEL1310110022#
reversible: true
is described by: ECO:0000000
product: MODEL1310110022#
reactant: MODEL1310110022#

metaM pail345p hs c
has only substance units: false
boundary condition: false
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:57836
type: Species

metaM HC01496 m
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
is: SBO:0000247
is: CHEBI:28095
has only substance units: false
initial amount: NaN
name: 2-Amino-3-oxoadipate
boundary condition: false

metaM o2s n
initial amount: NaN
name: superoxide
is: HMDB02168
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: CHEBI:18421

metaM HC00250 c
name: hydrosulfide
has only substance units: false
boundary condition: false
is: CHEBI:29919
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN

metaM dhbpt c
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
has only substance units: false
is: HMDB00038
is: CHEBI:20680
boundary condition: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
name: 6,7-dihydrobiopterin
initial amount: NaN

metaR r1561
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
product: MODEL1310110022#
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_86862718_c1ab_4a42_ace0_2e007ea7760b
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:80025
is: SBO:0000252
has only substance units: false
boundary condition: true
name: PANK2
constant: false

metaR ABTti
product: MODEL1310110022#
fast: false
reactant: MODEL1310110022#
reversible: false
is: SBO:0000185
is described by: ECO:0000000
name: L-arabinitol transport via passive diffusion
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
kinetic law: MODEL1310110022#

metaM h2o l
name: water
has only substance units: false
is: HMDB02111
initial amount: NaN
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:15377
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_3be29ef0_ddb6_4d1a_ab97_eb02e62ee5d6
is: P15954
type: Species
is encoded by: hsa:1350
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: COX7C
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_677c89af_5296_4fcb_81f5_f168df6c8c4c
name: NME7
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:29922

metaR GGH 10FTHF6GLUl
is: SBO:0000176
name: Gamma-glutamyl hydrolase (10FTHF6GLU), lysosomal
kinetic law: MODEL1310110022#
reversible: false
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.4.19.9
fast: false
type: Reaction
modifier: MODEL1310110022#
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110022#_a244e5e1_1afa_4281_ac50_b6c43bed4175
name: PLCB1
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:23236
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR UGCG
is described by: ECO:0000000
type: Reaction
name: Ceramide glucosyltransferase
notes: GENE_ASSOCIATION: (7357.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES:NJ
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.4.1.80
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
fast: false
product: MODEL1310110022#
is: SBO:0000176
reversible: false

metaM chol c
is: HMDB00097
type: Species
boundary condition: false
initial concentration: 1.0
name: Choline
is: SBO:0000247
initial amount: NaN
is: CHEBI:15354
has only substance units: false
constant: false
is: C00114
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114

W3 CDTF: Fri Aug 31 05:41:37 BST 2012

metaM hspg l
is: SBO:0000247
constant: false
is: CHEBI:17899
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
name: heparan sulfate proteoglycan
initial concentration: 1.0
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
is: HMDB01993

http://identifiers.org/biomodels.db/MODEL1310110022#_6cb95344_7620_4357_af7d_387f57b747c8
name: HSD11B2
initial amount: NaN
is: P80365
is encoded by: hsa:3291
initial concentration: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR r1560
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110022#
is: SBO:0000185
product: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_112f9b01_1822_4865_ab0c_8227f9e517e5
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3948
boundary condition: true
type: Species
constant: false
has only substance units: false
is: SBO:0000252
name: LDHC

http://identifiers.org/biomodels.db/MODEL1310110022#_c90f0a95_702d_41b3_ac8d_df12deadf6ef
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: SUCLG1
has only substance units: false
constant: false
is encoded by: hsa:8802
initial concentration: NaN
is: P53597
type: Species

metaR UGT1A10r
modifier: MODEL1310110022#
is described by: ECO:0000134
fast: false
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
is version of: http://identifiers.org/ec-code/2.4.1.17
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified
product: MODEL1310110022#
reversible: true
is: SBO:0000176
type: Reaction

metaM malthp e
constant: false
type: Species
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5041
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
boundary condition: false
initial amount: NaN
is: C01936
has only substance units: false
initial concentration: 1.0
name: maltoheptaose

metaR PPPGOm
notes: GENE_ASSOCIATION: (5498.1) SUBSYSTEM: Heme synthesis EC Number: 1.3.3.4 Confidence Level: 2 AUTHORS: PMID:8771201 NOTES:NCD
product: MODEL1310110022#
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.4
is: SBO:0000176
modifier: MODEL1310110022#
reversible: false
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000304
name: protoporphyrinogen oxidase, mitochondrial
type: Reaction

metaR GGH 5DHFe
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
is described by: ECO:0000000
modifier: MODEL1310110022#
name: Gamma-glutamyl hydrolase (5DHF), extracellular
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.4.19.9
type: Reaction
reactant: MODEL1310110022#
reversible: false
is: SBO:0000176
fast: false
product: MODEL1310110022#

metaM acac e
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:13705
name: acetoacetate
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: HMDB00060
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_9d9ae7e8_e1f2_40b3_b589_648fecbb021d
constant: false
name: ITPKB
initial amount: NaN
is: P27987
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3707
type: Species

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

metaR CYSO
is version of: http://identifiers.org/ec-code/1.13.11.20
modifier: MODEL1310110022#
product: MODEL1310110022#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (1036.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES:IT
kinetic law: MODEL1310110022#
is described by: ECO:0000269
fast: false
reversible: false
name: cysteine oxidase

W3 CDTF: Fri Aug 31 05:41:37 BST 2012

metaR EX fmn LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for FMN
type: Reaction

metaR RE3050R
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110022#
name: RE3050
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215 NOTES:
reversible: true
reactant: MODEL1310110022#
is: SBO:0000176
kinetic law: MODEL1310110022#

metaR ACETONEt2
type: Reaction
modifier: MODEL1310110022#
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110022#
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
kinetic law: MODEL1310110022#
is described by: ECO:0000269
name: acetone transport via proton symport

metaR LYStip
type: Reaction
kinetic law: MODEL1310110022#
is described by: ECO:0000000
product: MODEL1310110022#
reactant: MODEL1310110022#
name: L-lysine transport, peroxisomal (irreversible)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:6811962 NOTES:MM
fast: false
reversible: false
is: SBO:0000185

metaR r2118
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110022#
product: MODEL1310110022#
modifier: MODEL1310110022#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction

metaR r0735
is version of: http://identifiers.org/ec-code/1.2.1.3
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
modifier: MODEL1310110022#
product: MODEL1310110022#
fast: false
reversible: true
reactant: MODEL1310110022#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:

metaM ksi deg22 l
boundary condition: false
constant: false
name: keratan sulfate I, degradation product 22
has only substance units: false
is: HMDB01354
notes: FORMULA: C132H214N9O111S5 CHARGE: -5
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:57455

metaR RE0691C
fast: false
reversible: true
name: RE0691
type: Reaction
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
is described by: ECO:0000000
product: MODEL1310110022#

metaR SUCOASm
is version of: http://identifiers.org/ec-code/6.2.1.5
product: MODEL1310110022#
name: Succinate--CoA ligase (ADP-forming)
type: Reaction
reversible: true
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/6.2.1.4
fast: false
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD

http://identifiers.org/biomodels.db/MODEL1310110022#_f211b1d2_66d2_4740_9ba0_7a2f861a64eb
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5091
initial concentration: NaN
constant: false
type: Species
name: PC
boundary condition: true
is: P11498

http://identifiers.org/biomodels.db/MODEL1310110022#_481198f4_b3b5_41d2_af98_d8a0577976a2
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:622
type: Species
name: BDH1

http://identifiers.org/biomodels.db/MODEL1310110022#_bbdab862_f6c5_48c0_a11a_79d298378b37
name: GCDH
is: Q92947
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
constant: false
is encoded by: hsa:2639

http://identifiers.org/biomodels.db/MODEL1310110022#_f72f50f5_28a0_4885_9c4f_de29af1039be
type: Species
is: SBO:0000252
name: _AI620219_1_e
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AI620219
has only substance units: false
boundary condition: true
constant: false

W3 CDTF: Fri Aug 31 05:41:38 BST 2012

metaM pro L m
is: SBO:0000247
initial concentration: 1.0
name: L-proline
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: HMDB00162
is: CHEBI:17203
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
boundary condition: false

metaM lnlncg r
is: HMDB03073
constant: false
has only substance units: false
name: gamma-linolenate
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:32391
type: Species
initial amount: NaN
boundary condition: false

metaM HC02180 e
name: thromboxane-b2
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:28728
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
has only substance units: false
type: Species

metaR DPCOAK
is version of: http://identifiers.org/ec-code/2.7.7.3
name: dephospho-CoA kinase
is: SBO:0000176
is described by: ECO:0000269
fast: false
reactant: MODEL1310110022#
reversible: false
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110022#
product: MODEL1310110022#
type: Reaction

metaR r2119
type: Reaction
product: MODEL1310110022#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110022#
is described by: ECO:0000000
modifier: MODEL1310110022#
reactant: MODEL1310110022#
fast: false

metaM mescon m
is: CHEBI:36986
is: HMDB00749
type: Species
has only substance units: false
name: Mesaconate
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
constant: false
boundary condition: false
initial amount: NaN

metaR GMPtg
name: GMP transport (Golgi)
product: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:
reversible: true
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110022#_85ddd396_24df_499d_8324_a4fed3867439
boundary condition: true
type: Species
name: _J03866_1_m
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:J03866
initial concentration: NaN

metaM acac c
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
name: acetoacetate
is: CHEBI:13705
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: HMDB00060
has only substance units: false
constant: false
is: SBO:0000247

metaM pyr m
is: HMDB00243
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/3324
is: CHEBI:15361
is: C00022
type: Species
has only substance units: false
name: pyruvate
initial amount: NaN

metaM chol e
has only substance units: false
is: CHEBI:15354
initial amount: NaN
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
boundary condition: false
type: Species
initial concentration: 1.0
is: C00114
is: SBO:0000247
constant: false
is: HMDB00097
name: Choline

metaR r1798
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110022#
reversible: false
fast: false
is: SBO:0000185
product: MODEL1310110022#
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110022#_622f6373_bf80_447f_87e9_0998b597c686
name: PLCB4
is encoded by: hsa:5332
constant: false
type: Species
is: Q15147
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaM ksi deg14 l
is: SBO:0000247
notes: FORMULA: C166H267N11O145S8 CHARGE: -8
boundary condition: false
has only substance units: false
is: HMDB00143
type: Species
constant: false
name: keratan sulfate I, degradation product 14
is: CHEBI:12936
initial concentration: 1.0
initial amount: NaN

metaR XAOx
reactant: MODEL1310110022#
reversible: false
is described by: ECO:0000269
name: xanthine oxidase,peroxisomal
type: Reaction
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
product: MODEL1310110022#
fast: false
is version of: http://identifiers.org/ec-code/1.17.1.4
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Purine catabolism EC Number: 1.1.1.204 Confidence Level: 4 AUTHORS: PMID:12637268,PMID:8670112 NOTES:IT (1.17.3.2)
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110022#_37efac9a_5a89_44fd_a653_569de0eccb56
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:51557
type: Species
is: Q5TDP6
name: LGSN
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

metaR XYLTt
name: Xylitol transport via passive diffusion
product: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110022#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES:NCD
is described by: ECO:0000000

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_4bc462b2_4953_45c2_9447_9f945a4dbad9
is: SBO:0000252
is: P15531
name: NME1
constant: false
is encoded by: hsa:4830
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species

metaM HC01231 c
initial amount: NaN
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
is: CHEBI:58480
has only substance units: false
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: N-[(R)-pantothenoyl]-L-cysteinate

metaR RETH1e
kinetic law: MODEL1310110022#
fast: false
reversible: false
name: retinyl ester hydrolase (9-cis), extracellular
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000176
reactant: MODEL1310110022#
type: Reaction
is described by: ECO:0000000

metaR r0488
kinetic law: MODEL1310110022#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:
fast: false
product: MODEL1310110022#
type: Reaction
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34
reversible: true

metaM aacoa m
constant: false
has only substance units: false
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
type: Species
is: HMDB01484
initial amount: NaN
name: acetoacetyl-CoA(4-)
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57286

metaM 13 cis retn r
initial amount: NaN
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
has only substance units: false
is: SBO:0000247
is: D00348
type: Species
is: http://identifiers.org/pubchem.compound/7847414
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB06219
name: 13-cis-retinoate

metaM o2s x
boundary condition: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: CHEBI:18421
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: superoxide
is: HMDB02168
type: Species

metaR CYTK5n
kinetic law: MODEL1310110022#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110022#
fast: false
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
name: cytidylate kinase (CMP),nuclear
product: MODEL1310110022#
reactant: MODEL1310110022#

metaR ACt2r
name: acetate reversible transport via proton symport
is: SBO:0000185
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
fast: false
reversible: true
product: MODEL1310110022#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110022#_435b53ed_7dbb_442f_bf79_ea3bcfddb767
name: _U52111_1_c
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:U52111
constant: false
is: SBO:0000252

metaR OMHDOCOSACTD
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of w-hydroxydocosanoic acid by diffusion
type: Reaction

metaM rbt e
initial concentration: 1.0
is: HMDB00508
is: SBO:0000247
name: D-ribitol
constant: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:15963

metaM 2oxoadp m
has only substance units: false
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
name: 2-oxoadipate(2-)
is: HMDB00225
is: SBO:0000247
boundary condition: false
is: CHEBI:57499

metaR GGH 5THFe
is version of: http://identifiers.org/ec-code/3.4.19.9
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
is described by: ECO:0000000
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110022#
reversible: false
modifier: MODEL1310110022#
name: Gamma-glutamyl hydrolase (5THF), extracellular
product: MODEL1310110022#

metaR ASNtN1
kinetic law: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
fast: false
is: SBO:0000185
reactant: MODEL1310110022#
reversible: true
modifier: MODEL1310110022#
product: MODEL1310110022#
name: Asparagine transport (Na, H coupled)
is described by: ECO:0000269

metaM ocdca c
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
has only substance units: false
type: Species
is: CHEBI:25629
is: SBO:0000247
name: stearate
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00827
boundary condition: false

metaR GGH 10FTHF6GLUe
is version of: http://identifiers.org/ec-code/3.4.19.9
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reversible: false
is described by: ECO:0000000
is: SBO:0000176
fast: false
modifier: MODEL1310110022#
reactant: MODEL1310110022#
name: Gamma-glutamyl hydrolase (10FTHF6GLU), extracellular
kinetic law: MODEL1310110022#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_bd5eb3f7_db9a_4197_9f2b_a582602fafc7
initial concentration: NaN
name: UAP1
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: Q16222
type: Species
constant: false
is encoded by: hsa:6675

metaR EX pectingchol LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pectin-glycocholate complex
type: Reaction

metaM ppcoa m
initial amount: NaN
is: CHEBI:57392
constant: false
is: SBO:0000247
is: HMDB01275
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: Propanoyl-CoA
type: Species
is: C00100
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100

metaR RE1897C
type: Reaction
reversible: true
is: SBO:0000176
reactant: MODEL1310110022#
name: RE1897
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
product: MODEL1310110022#
kinetic law: MODEL1310110022#
fast: false

metaR r1639
kinetic law: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110022#
fast: false
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110022#
type: Reaction

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_f3c0a563_2125_4818_bbf4_3cc132b15021
constant: false
boundary condition: true
is encoded by: hsa:3939
has only substance units: false
is: P00338
type: Species
initial amount: NaN
name: LDHA
initial concentration: NaN
is: SBO:0000252

metaM rbt c
is: CHEBI:15963
initial concentration: 1.0
boundary condition: false
is: HMDB00508
is: SBO:0000247
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
has only substance units: false
constant: false
type: Species
initial amount: NaN
name: D-ribitol

metaM HC00591 m
has only substance units: false
is: CHEBI:16769
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: 2-oxoglutaramate
constant: false
type: Species

metaR PROSTGD2t
reactant: MODEL1310110022#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
reversible: true
kinetic law: MODEL1310110022#
product: MODEL1310110022#
is described by: ECO:0000269
name: prostaglandin transport via bicarbonate countertransport
fast: false

metaM HC01842 c
name: Phosphodimethylethanolamine
is: CHEBI:31997
boundary condition: false
type: Species
constant: false
has only substance units: false
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaM h2o n
name: water
is: HMDB02111
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: CHEBI:15377
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaR CYSTSERex
kinetic law: MODEL1310110022#
name: L-cystine/glycine exchanger (cystine in)
reversible: false
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (6519.1 and 11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: NOTES:SAB see PMID 14770310
reactant: MODEL1310110022#
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
product: MODEL1310110022#
fast: false

metaR Htg
product: MODEL1310110022#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: proton diffusion (Golgi)
reactant: MODEL1310110022#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110022#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110022#_1dbe44b0_3239_4e91_b6c0_b709d67b4e42
boundary condition: true
is encoded by: hsa:65010
initial amount: NaN
type: Species
name: SLC26A6
has only substance units: false
is: Q9NQU1
is: SBO:0000252
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_c31a899c_2a44_4890_b1da_8d6edabae460
is encoded by: hsa:2538
initial amount: NaN
initial concentration: NaN
name: G6PC
constant: false
is: SBO:0000252
boundary condition: true
type: Species
is: P35575
has only substance units: false

metaR r0181
fast: false
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110022#
is: SBO:0000176
reversible: true
modifier: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110022#_a5a93673_d2b3_4bb0_b0fa_4111eacdbc30
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is: P00374
name: DHFR
is: SBO:0000252
is encoded by: hsa:1719
constant: false

metaM h2o m
is: C00001
boundary condition: false
is: CHEBI:15377
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: HMDB02111
is: SBO:0000247
name: H2O
type: Species
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR UPP3S
fast: false
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/4.2.1.75
reactant: MODEL1310110022#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (7390.1) SUBSYSTEM: Heme synthesis EC Number: 4.2.1.75 Confidence Level: 0 AUTHORS: PMID:3174619 NOTES:
is: SBO:0000176
is described by: ECO:0000000
name: uroporphyrinogen-III synthase
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#

metaM dmpp x
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:57623
initial concentration: 1.0
name: prenyl diphosphate(3-)
constant: false
is: SBO:0000247
is: HMDB01120
has only substance units: false
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h3H,4H2,1-2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00213 EHMN_ABBREVIATION: C00235

http://identifiers.org/biomodels.db/MODEL1310110022#_bbe5631a_be0d_4a74_bcf0_33dc7910c024
name: CTH
constant: false
initial amount: NaN
initial concentration: NaN
is: P32929
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:1491
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110022#_77492a7c_e643_48a1_b9b5_f09821f317c7
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:2591
constant: false
is: SBO:0000252
name: GALNT3
is: Q14435
boundary condition: true
type: Species

metaM ksi deg35 l
is: HMDB00143
notes: FORMULA: C68H113N4O54S1 CHARGE: -1
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:12936
boundary condition: false
initial amount: NaN
constant: false
name: keratan sulfate I, degradation product 35
is: SBO:0000247

metaR PROt4 2 r
type: Reaction
is described by: ECO:0000006
kinetic law: MODEL1310110022#
is: SBO:0000185
fast: false
product: MODEL1310110022#
name: Proline transport (sodium symport) (2:1)
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reversible: true
modifier: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_482ab7f3_8e2d_465b_b930_0f5e49330d5e
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:123041
type: Species
has only substance units: false
is: SBO:0000252
name: SLC24A4
constant: false

metaR HIBDm
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
reactant: MODEL1310110022#
type: Reaction
kinetic law: MODEL1310110022#
fast: false
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.31
product: MODEL1310110022#
modifier: MODEL1310110022#
is: SBO:0000176

metaM ddsmsterol r
name: 7-dehydrodesmosterol
constant: false
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9-10,19,21,23-25,28H,6,8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01373
type: Species
is: SBO:0000247
is: HMDB03896
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:27910

metaM gchola x
name: glycocholate
notes: FORMULA: C26H43NO6 CHARGE: 0 INCHI: InChI=1S/C26H43NO6/c1-14(4-7-22(31)27-13-23(32)33)17-5-6-18-24-19(12-21(30)26(17,18)3)25(2)9-8-16(28)10-15(25)11-20(24)29/h14-21,24,28-30H,4-13H2,1-3H3,(H,27,31)(H,32,33)/p-1/t14-,15+,16-,17-,18+,19+,20-,21+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:58235
is: HMDB00138
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110022#_d07b8c72_9606_49f8_9d07_c71909faf431
is encoded by: hsa:642502
initial concentration: NaN
name: _642502_1_c
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
type: Species

metaR RE0908C
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110022#
name: RE0908
reversible: true
reactant: MODEL1310110022#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Tyrosine metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11861502,PMID:2765556,PMID:3988241,PMID:7263841,PMID:8767510 NOTES:
product: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_f0324490_a033_4ba0_b539_3598daa31a78
is: Q9H6R3
initial amount: NaN
type: Species
has only substance units: false
constant: false
is encoded by: hsa:79611
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: ACSS3

http://identifiers.org/biomodels.db/MODEL1310110022#_e9dd3310_53ae_4240_8dd4_f8a5d53d1d0d
boundary condition: true
type: Species
name: PLCH1
has only substance units: false
is: Q4KWH8
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:23007

metaR THYOXt
product: MODEL1310110022#
reactant: MODEL1310110022#
name: T4 transport via bicarbonate countertransport
fast: false
reversible: true
kinetic law: MODEL1310110022#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (53919.1) or (6579.1) or (28231.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110022#_1d14b1ef_da09_435d_a1a1_6d280eccf425
is encoded by: hsa:8883
is: A8MU28
constant: false
type: Species
has only substance units: false
name: NAE1
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaM HC02206 c
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
name: prostaglandin C1(1-)
constant: false
is: CHEBI:57399

metaR B3GNT51g
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (84002.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
kinetic law: MODEL1310110022#
is described by: ECO:0000304
product: MODEL1310110022#
fast: false
modifier: MODEL1310110022#
reactant: MODEL1310110022#
type: Reaction

metaR HSD3A2r
is: SBO:0000176
modifier: MODEL1310110022#
product: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.225
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
kinetic law: MODEL1310110022#
type: Reaction
reactant: MODEL1310110022#

metaM dpcoa m
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
initial amount: NaN
is: CHEBI:57328
name: 3'-dephospho-CoA(2-)
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB01373

metaM rnam c
type: Species
name: N-Ribosylnicotinamide
initial amount: NaN
has only substance units: false
is: CHEBI:15927
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C11H15N2O5 CHARGE: 1 INCHI: InChI=1S/C11H14N2O5/c12-10(17)6-2-1-3-13(4-6)11-9(16)8(15)7(5-14)18-11/h1-4,7-9,11,14-16H,5H2,(H-,12,17)/p+1/t7-,8-,9-,11-/m1/s1 EHMN_ABBREVIATION: C03150
constant: false
is: SBO:0000247
is: HMDB00855

metaM h2o c
initial amount: NaN
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
name: H2O
notes: FORMULA: H2O CHARGE: 0
is: HMDB02111
is: CHEBI:3303
is: C00001
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_a8f2c2a6_8687_43f0_8f47_11142ae90e7b
is encoded by: hsa:2348
name: FOLR1
has only substance units: false
is: P15328
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
type: Species
is: SBO:0000252

metaR r2338
fast: false
kinetic law: MODEL1310110022#
is: SBO:0000185
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
product: MODEL1310110022#
reactant: MODEL1310110022#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:

metaR BAAT1x
reactant: MODEL1310110022#
product: MODEL1310110022#
is described by: ECO:0000269
kinetic law: MODEL1310110022#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.65
name: bile acid Coenzyme A: amino acid N-acyltransferase
fast: false
modifier: MODEL1310110022#

metaR URATEt
is described by: ECO:0000000
type: Reaction
fast: false
reversible: false
name: urate export from cytosol
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110022#
is: SBO:0000185
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#

metaM ade c
name: Adenine
is: CHEBI:16708
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
is: HMDB00034
is: C00147
constant: false
initial amount: NaN
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147

metaM chol m
has only substance units: false
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
initial amount: NaN
initial concentration: 1.0
type: Species
name: choline
is: HMDB00097
is: CHEBI:15354
is: SBO:0000247
constant: false
boundary condition: false

metaM ocdca e
initial amount: NaN
is: CHEBI:25629
initial concentration: 1.0
is: HMDB00827
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
has only substance units: false
type: Species
is: C01530
boundary condition: false
is: SBO:0000247
constant: false
name: octadecanoate (n-C18:0)

http://identifiers.org/biomodels.db/MODEL1310110022#_e44997b7_4caa_4c6a_9867_d83796a46b70
is: Q5JT09
initial amount: NaN
boundary condition: true
is encoded by: hsa:83549
constant: false
has only substance units: false
initial concentration: NaN
name: UCK1
type: Species
is: SBO:0000252

metaR ARACHDtr
product: MODEL1310110022#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
type: Reaction
name: intracellular transport
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110022#

metaR EX cyan LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen cyanide exchange
type: Reaction

metaM HC02206 e
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
constant: false
name: prostaglandin C1(1-)
is: CHEBI:57399

http://identifiers.org/biomodels.db/MODEL1310110022#_4187afc3_36f8_4ac5_9994_ddb282ff8761
is: B2RB13
has only substance units: false
type: Species
initial amount: NaN
name: ACSL6
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:23305
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110022#_736b7192_22a3_4c42_91f8_72a6fdf06c53
constant: false
name: _T83654_1_m
type: Species
is encoded by: hsa:T83654
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110022#_40561795_865b_46d7_b509_483ccf7aeb08
has only substance units: false
initial concentration: NaN
is encoded by: hsa:55825
name: PECR
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: Q9BY49
constant: false
type: Species

metaM ksii core4 deg3 l
is: HMDB00143
name: keratan sulfate II (core 4-linked), degradation product 3
has only substance units: false
is: CHEBI:12936
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C66H107N6O51S2X CHARGE: -2
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaR CYTK6n
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110022#
name: cytidylate kinase (CMP,CTP),nuclear
modifier: MODEL1310110022#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110022#_fc5fa687_e055_4a84_bd63_1d0c210cec6e
initial concentration: NaN
constant: false
is encoded by: hsa:19
is: O95477
name: ABCA1
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true

metaM ksi deg37 l
boundary condition: false
notes: FORMULA: C62H104N4O46 CHARGE: 0
is: CHEBI:57455
constant: false
name: keratan sulfate I, degradation product 37
type: Species
initial amount: NaN
is: HMDB01354
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaR EX HC02205 LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b2 exchange
type: Reaction

metaR LEUKTRF4t
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
name: leukotriene F4 transport
fast: false
reversible: true

metaR PMTCOAtx
product: MODEL1310110022#
fast: false
is: SBO:0000185
name: fatty acid intracellular transport
kinetic law: MODEL1310110022#
is described by: ECO:0000000
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
reversible: true

metaR r0517
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.17.4.1
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
is: SBO:0000176
fast: false
kinetic law: MODEL1310110022#
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
modifier: MODEL1310110022#
type: Reaction
reactant: MODEL1310110022#

metaR BILDGLCURt
type: Reaction
product: MODEL1310110022#
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
is: SBO:0000185
modifier: MODEL1310110022#
is described by: ECO:0000269
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
fast: false
reactant: MODEL1310110022#
reversible: true

metaR PGLer
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 3.1.1.31 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:SMP Net reaction same as described in Lehringer 334 NCD
product: MODEL1310110022#
reactant: MODEL1310110022#
reversible: false
name: 6-phosphogluconolactonase, endoplasmic reticulum
is version of: http://identifiers.org/ec-code/1.1.1.47
kinetic law: MODEL1310110022#
type: Reaction
fast: false
is: SBO:0000176
is described by: ECO:0000269

metaM ade e
is: CHEBI:16708
is: SBO:0000247
name: adenine
type: Species
initial concentration: 1.0
is: HMDB00034
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
has only substance units: false

metaR CYTK14n
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110022#
is described by: ECO:0000269
name: cytidylate kinase (dCMP,CTP),nuclear
is: SBO:0000176
product: MODEL1310110022#
modifier: MODEL1310110022#
reactant: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_5a87458c_5dc7_47a7_b7c9_63034efc99d5
boundary condition: true
constant: false
is encoded by: hsa:U37519
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: _U37519_1_e
type: Species
has only substance units: false

metaR CITL
fast: false
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
is described by: ECO:0000000
name: Citrate lyase
product: MODEL1310110022#
modifier: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000176
kinetic law: MODEL1310110022#
reversible: false
type: Reaction

metaR EX glyc LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycerol exchange
type: Reaction

metaM h2o g
name: water
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB02111
constant: false
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:15377

http://identifiers.org/biomodels.db/MODEL1310110022#_d0ddc06d_e1d2_4f02_9005_e9e3cd179dae
is: P31350
has only substance units: false
is: SBO:0000252
boundary condition: true
name: RRM2
is encoded by: hsa:6241
type: Species
initial amount: NaN
constant: false
initial concentration: NaN

metaM chol g
name: choline
is: CHEBI:15354
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB00097

metaM pmtcoa c
constant: false
initial amount: NaN
is: HMDB01338
is: C00154
is: CHEBI:3454
type: Species
initial concentration: 1.0
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
boundary condition: false
name: Palmitoyl-CoA (n-C16:0CoA)
is: SBO:0000247
has only substance units: false

metaM omhdocosac c
type: Species
is: http://identifiers.org/pubchem.compound/5282922
notes: FORMULA: C22H42O3 CHARGE: -1
name: w-hydroxydocosanoicacid
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110022#_e728869d_391d_402e_b3b7_2cbce198942a
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:AD000092
initial amount: NaN
has only substance units: false
name: _AD000092_1_c
boundary condition: true

metaM g3p c
boundary condition: false
type: Species
initial concentration: 1.0
is: C00661
is: HMDB01112
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3930
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:58027
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
name: Glyceraldehyde 3-phosphate

metaR S2TASE2ly
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
name: iduronate-2-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.13
is: SBO:0000176
reactant: MODEL1310110022#
is described by: ECO:0000000
fast: false
product: MODEL1310110022#
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_907c4690_19dd_46ee_8df6_d0b88f7315b1
boundary condition: true
constant: false
is encoded by: hsa:50484
is: SBO:0000252
name: RRM2B
initial concentration: NaN
type: Species
is: Q7LG56
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_41346ddb_0566_4ea3_99a3_d28431788e29
initial concentration: NaN
constant: false
is encoded by: hsa:10723
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: Q9Y666
has only substance units: false
name: SLC12A7
type: Species

metaR EX leuktrC4 LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leukotriene C4 exchange
type: Reaction

metaM o2 e
is: HMDB01377
has only substance units: false
initial concentration: 1.0
is: CHEBI:15379
type: Species
constant: false
is: SBO:0000247
is: C00007
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
boundary condition: false
initial amount: NaN
name: O2

metaR r0186
type: Reaction
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
is: SBO:0000176
fast: false
reversible: false
modifier: MODEL1310110022#

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

metaM ksii core2 deg7 l
type: Species
constant: false
is: HMDB01354
initial concentration: 1.0
name: keratan sulfate II (core 2-linked), degradation product 7
has only substance units: false
is: SBO:0000247
notes: FORMULA: C44H73N4O30X CHARGE: 0
initial amount: NaN
is: CHEBI:57455
boundary condition: false

metaR RE2660N
is described by: ECO:0000000
reactant: MODEL1310110022#
modifier: MODEL1310110022#
product: MODEL1310110022#
name: RE2660
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.96
fast: false
kinetic law: MODEL1310110022#
reversible: true
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
is: SBO:0000176

metaM pro D e
name: D-proline
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
boundary condition: false
initial amount: NaN
is: CHEBI:16313
is: HMDB03411
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_2e4b1ce4_4fa1_4db5_bd02_0fa9bc7d70b6
is: SBO:0000252
initial amount: NaN
is: O43678
has only substance units: false
is encoded by: hsa:4695
name: NDUFA2
constant: false
type: Species
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_a1008a25_e845_46e9_845a_14a713d000c9
boundary condition: true
initial amount: NaN
name: _H77542_1_c
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:H77542

metaR ENGASE3ly
fast: false
name: endo-beta-N-acetylglucosaminidase, lysosomal
kinetic law: MODEL1310110022#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110022#
type: Reaction

metaR CO2t
product: MODEL1310110022#
is: SBO:0000185
reactant: MODEL1310110022#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
type: Reaction
reversible: true
name: CO2 transporter via diffusion
fast: false
kinetic law: MODEL1310110022#

metaM C05965 e
name: 12(S)-HPETE(1-)
is: CHEBI:57444
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
type: Species
is: HMDB04243
boundary condition: false
initial amount: NaN

metaM h2o e
is: CHEBI:15377
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: HMDB02111
boundary condition: false
name: H2O
constant: false
type: Species
is: C00001

http://identifiers.org/biomodels.db/MODEL1310110022#_198bbae9_8e67_4427_991b_1ccea045a8c8
is encoded by: hsa:AI345944
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
name: _AI345944_1_m
is: SBO:0000252
constant: false

metaR RE1447N
type: Reaction
reversible: true
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
reactant: MODEL1310110022#
fast: false
name: RE1447
product: MODEL1310110022#
kinetic law: MODEL1310110022#

metaR ILETAm
is version of: http://identifiers.org/ec-code/2.6.1.42
product: MODEL1310110022#
reversible: true
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
reactant: MODEL1310110022#
name: isoleucine transaminase, mitochondrial
is: SBO:0000176
modifier: MODEL1310110022#
type: Reaction
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110022#_9e4e5929_4007_430e_a1ca_0ba6f7b5c6ac
type: Species
initial amount: NaN
name: NME1
boundary condition: true
constant: false
is encoded by: hsa:4830
initial concentration: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110022#_c8b30927_429a_48c6_8f23_413e132a8967
name: ALAD
type: Species
constant: false
has only substance units: false
is: SBO:0000252
is: P13716
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:210

metaR PI45P5P
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
reversible: false
fast: false
product: MODEL1310110022#
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.36
modifier: MODEL1310110022#
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110022#_822a6334_619e_4262_974b_e23b0a89d7cf
is: P30837
is encoded by: hsa:219
type: Species
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: ALDH1B1

http://identifiers.org/biomodels.db/MODEL1310110022#_d590d447_a550_4cd9_a273_840b6bc6fbf0
is: P21217
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
name: FUT3
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:2525

http://identifiers.org/biomodels.db/MODEL1310110022#_8fcb0986_0fa4_49df_bac9_a75a38476abd
boundary condition: true
is encoded by: hsa:4831
is: P22392
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
name: NME2
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_ee690c57_fca5_4f58_9cc0_4c834b137a52
is: Q99755
type: Species
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:8394
name: PIP5K1A

http://identifiers.org/biomodels.db/MODEL1310110022#_8d965609_29a6_4ab3_a1e0_8605f2aa7010
has only substance units: false
constant: false
name: SCP2
is: C9JC79
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6342
boundary condition: true
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_64979831_9cc3_4192_9939_81cd0fbb17aa
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:221823
constant: false
name: PRPS1L1
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR EX retfa LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid retinol exchange
type: Reaction

metaM fadh2 r
boundary condition: false
is: HMDB01197
is: SBO:0000247
name: FADH2(2-)
constant: false
has only substance units: false
is: CHEBI:58307
initial amount: NaN
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_bcc42af4_bf6e_40b3_be25_bcb6ea0122bd
name: SLC35D2
type: Species
is encoded by: hsa:11046
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
is: Q76EJ3
constant: false
is: SBO:0000252

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

metaM pro D c
name: D-proline
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
constant: false
boundary condition: false
is: CHEBI:16313
has only substance units: false
initial amount: NaN
is: HMDB03411

http://identifiers.org/biomodels.db/MODEL1310110022#_55e0deca_0192_4537_8fd4_19b111ce053d
is: Q96KJ9
initial concentration: NaN
is encoded by: hsa:84701
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
constant: false
name: COX4I2

metaM o2 c
is: HMDB01377
initial concentration: 1.0
type: Species
is: CHEBI:15379
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
is: C00007
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
name: O2
initial amount: NaN

metaM inost e
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
is: HMDB00211
initial concentration: 1.0
has only substance units: false
constant: false
name: myo-inositol
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:17268
initial amount: NaN

metaR r0627
is described by: ECO:0000000
product: MODEL1310110022#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
kinetic law: MODEL1310110022#
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_43ef75ef_91e9_487e_ab9a_5448ed72233a
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:3417
is: O75874
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
name: IDH1

metaM spmd e
has only substance units: false
is: HMDB01257
initial concentration: 1.0
is: C00315
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
type: Species
is: CHEBI:57834
name: Spermidine
is: SBO:0000247

metaR r1642
modifier: MODEL1310110022#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110022#
is described by: ECO:0000000
fast: false
product: MODEL1310110022#
kinetic law: MODEL1310110022#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM asp L e
is: SBO:0000247
is: HMDB00191
initial concentration: 1.0
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
name: L-aspartate(1-)
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: CHEBI:29991
boundary condition: false

metaM lnlncg c
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB03073
has only substance units: false
is: CHEBI:32391
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
constant: false
boundary condition: false
name: gamma-linolenate

http://identifiers.org/biomodels.db/MODEL1310110022#_cf732ec1_9ac7_4cec_83da_8964385e6ec5
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is: Q16878
type: Species
name: CDO1
is encoded by: hsa:1036
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_a0b04279_dfea_4984_8f67_195b84e427ac
constant: false
has only substance units: false
type: Species
name: DGKD
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8527
boundary condition: true

metaR r2331
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110022#
type: Reaction
product: MODEL1310110022#
fast: false
reactant: MODEL1310110022#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR LEUTAm
name: leucine transaminase, mitochondrial
fast: false
type: Reaction
reversible: true
product: MODEL1310110022#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.6.1.42
is: SBO:0000176
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#

metaR H2Otn
reversible: true
product: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: H2O transport, nuclear
type: Reaction
kinetic law: MODEL1310110022#

metaM lac D e
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
constant: false
is: CHEBI:16004
initial concentration: 1.0
name: (R)-lactate
is: HMDB01311
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110022#_680ba775_c137_4531_a038_afde4c5e83e0
has only substance units: false
type: Species
is encoded by: hsa:AV727634
initial amount: NaN
name: _AV727634_1_c
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110022#_aa42228d_1e43_434d_8a30_711e418dd815
has only substance units: false
name: SLC25A10
type: Species
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: Q9UBX3
is encoded by: hsa:1468

http://identifiers.org/biomodels.db/MODEL1310110022#_4bbefab2_0120_41f1_94a8_aac04c628c37
is: SBO:0000252
is: Q12908
boundary condition: true
has only substance units: false
name: SLC10A2
constant: false
initial amount: NaN
is encoded by: hsa:6555
type: Species
initial concentration: NaN

metaR D3AIBTm
is described by: ECO:0000000
reversible: true
product: MODEL1310110022#
type: Reaction
reactant: MODEL1310110022#
fast: false
kinetic law: MODEL1310110022#
is: SBO:0000176
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM

metaM phe L c
is: SBO:0000247
is: HMDB00159
constant: false
name: L-phenylalanine
initial concentration: 1.0
is: CHEBI:17295
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
initial amount: NaN

metaM udpgal e
has only substance units: false
type: Species
constant: false
boundary condition: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
is: HMDB00302
is: CHEBI:58439
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: UDP-D-galactose(2-)

http://identifiers.org/biomodels.db/MODEL1310110022#_deb26066_c954_4fb4_9de2_e0e228e5ad6d
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: Q96DU7
is encoded by: hsa:80271
type: Species
boundary condition: true
name: ITPKC
constant: false
initial amount: NaN

metaR GALASE11ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
reactant: MODEL1310110022#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110022#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
name: beta-galactosidase, lysosomal

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

metaM HC02213 c
constant: false
boundary condition: false
is: CHEBI:28031
initial concentration: 1.0
name: prostaglandin-e3
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
is: SBO:0000247
type: Species

metaR r2330
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110022#
is: SBO:0000185
kinetic law: MODEL1310110022#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR r1641
kinetic law: MODEL1310110022#
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110022#
is: SBO:0000185
product: MODEL1310110022#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM Sfglutth c
is: SBO:0000247
boundary condition: false
is: HMDB01550
is: CHEBI:57688
constant: false
has only substance units: false
name: S-formylglutathionate(1-)
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
type: Species
initial concentration: 1.0
initial amount: NaN

metaR H2Otm
is described by: ECO:0000269
kinetic law: MODEL1310110022#
product: MODEL1310110022#
modifier: MODEL1310110022#
reactant: MODEL1310110022#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
type: Reaction
fast: false
name: H2O transport, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110022#_b7e17c87_27ac_4ab4_b1ea_38d98e95597b
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: _AI653169_1_c
type: Species
constant: false
is encoded by: hsa:AI653169
boundary condition: true

metaM dpcoa e
initial concentration: 1.0
is: SBO:0000247
is: C00882
is: HMDB01373
boundary condition: false
constant: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
has only substance units: false
initial amount: NaN
name: Dephospho-CoA
is: CHEBI:57328
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_f2730937_0a00_4eaf_bd56_51e5928ff2d1
type: Species
has only substance units: false
name: _NOS2A_1_e
is: SBO:0000252
constant: false
is encoded by: hsa:NOS2A
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaR r0629
is described by: ECO:0000000
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.1.4.1
is: SBO:0000176
reversible: true
fast: false
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
type: Reaction
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
is version of: http://identifiers.org/ec-code/3.6.1.22

metaM spmd c
is: SBO:0000247
initial concentration: 1.0
is: HMDB01257
is: C00315
initial amount: NaN
boundary condition: false
name: Spermidine
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
constant: false
has only substance units: false
type: Species
is: CHEBI:57834

metaR UMPKn
modifier: MODEL1310110022#
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110022#
fast: false
kinetic law: MODEL1310110022#
is described by: ECO:0000269
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD
is: SBO:0000176
name: UMP kinase, nuclear

metaR r1640
fast: false
reactant: MODEL1310110022#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#

metaR GLYSNAT5tc
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_25f47a4f_854f_426b_ade8_eb57bfd66c42
has only substance units: false
is: SBO:0000252
name: SLC5A9
constant: false
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:200010
is: E9PAK4
initial concentration: NaN

metaR PPAn
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: 3.6.1.1 Confidence Level: 1 AUTHORS: NOTES:
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000000
product: MODEL1310110022#
is: SBO:0000176
name: inorganic diphosphatase, nuclear
type: Reaction
reversible: false
fast: false

metaR H2Otp
product: MODEL1310110022#
is described by: ECO:0000000
name: H2O transport, peroxisomal
is: SBO:0000185
reactant: MODEL1310110022#
reversible: true
kinetic law: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false

http://identifiers.org/biomodels.db/MODEL1310110022#_2446bda0_76a1_4d8f_80ce_6eb8f1c3caca
has only substance units: false
name: QDPR
is encoded by: hsa:5860
initial concentration: NaN
boundary condition: true
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
is: P09417

http://identifiers.org/biomodels.db/MODEL1310110022#_9eaddd30_ef3b_4fad_ad95_5812db97ef08
is: SBO:0000252
is encoded by: hsa:1635
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: P32321
constant: false
name: DCTD
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_fae2779e_d033_4b4c_ab1d_23cc70742dc0
initial concentration: NaN
is: Q9UG56
is: SBO:0000252
name: PISD
type: Species
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:23761
initial amount: NaN

metaR PPAm
is described by: ECO:0000269
reactant: MODEL1310110022#
product: MODEL1310110022#
is: SBO:0000176
reversible: false
name: inorganic diphosphatase
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
is version of: http://identifiers.org/ec-code/3.6.1.1
fast: false
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
type: Reaction

metaM mi13p c
initial concentration: 1.0
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)5(17-19(11,12)13)4(10)6(3(1)9)18-20(14,15)16/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3+,4+,5+,6-
is: SBO:0000247
is: HMDB06234
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
name: 1D-myo-Inositol 1,3-bisphosphate
type: Species
is: CHEBI:18225

http://identifiers.org/biomodels.db/MODEL1310110022#_9c7f1d7d_1228_46d4_8803_b0deb3ed5172
name: SLC5A11
boundary condition: true
is encoded by: hsa:115584
has only substance units: false
type: Species
constant: false
is: Q8WWX8
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_b8a81eac_aa8d_4060_a43e_67ac8e337e74
is: Q99643
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:6391
has only substance units: false
name: SDHC

metaR HAS2
kinetic law: MODEL1310110022#
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
modifier: MODEL1310110022#
name: hyaluronan synthase
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110022#
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.4.1.212
fast: false

metaM udpgal c
has only substance units: false
type: Species
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:58439
is: HMDB00302
is: SBO:0000247
name: UDP-D-galactose(2-)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_a75eaf1d_3762_494d_b2a5_80ecd442ec43
name: SUCLG2
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:8801
boundary condition: true
is: Q96I99
type: Species

metaM cholp g
initial concentration: 1.0
type: Species
is: C00588
is: CHEBI:295975
constant: false
name: choline phosphate(1-)
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
has only substance units: false
boundary condition: false

metaM Ssq23epx r
boundary condition: false
name: (S)-2,3-epoxysqualene
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-24(2)14-11-17-27(5)20-12-18-25(3)15-9-10-16-26(4)19-13-21-28(6)22-23-29-30(7,8)31-29/h14-16,20-21,29H,9-13,17-19,22-23H2,1-8H3/b25-15+,26-16+,27-20+,28-21+/t29-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00645 EHMN_ABBREVIATION: C01054
is: SBO:0000247
is: CHEBI:15441
type: Species
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB01188

metaM docosdiac e
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/244872
name: docosanedioicacid
boundary condition: false
notes: FORMULA: C22H40O4 CHARGE: -2
has only substance units: false
initial amount: NaN

metaM HC02213 e
constant: false
has only substance units: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
boundary condition: false
is: CHEBI:28031
initial amount: NaN
initial concentration: 1.0
name: prostaglandin-e3
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_5c4488dd_091a_4930_b9de_457aa11b0668
initial concentration: NaN
constant: false
name: DHCR7
is: Q9UBM7
type: Species
boundary condition: true
is encoded by: hsa:1717
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR DCK2n
is described by: ECO:0000269
fast: false
reversible: true
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
is: SBO:0000176
modifier: MODEL1310110022#
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.7.1.74
product: MODEL1310110022#
kinetic law: MODEL1310110022#
type: Reaction
name: Deoxycytidine kinase, nuclear (UTP)

metaM dpcoa c
name: Dephospho-CoA
is: C00882
is: HMDB01373
is: CHEBI:57328
boundary condition: false
type: Species
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false

metaR EX 10fthf7glu LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](7) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_a0f5fc45_d5bd_4881_bc52_eec18104de36
is: SBO:0000252
name: NDUFA1
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
is: Q6IBB5
constant: false
initial concentration: NaN
is encoded by: hsa:4694

metaR GASNASE3ly
type: Reaction
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.5.1.26 Confidence Level: 4 AUTHORS: PMID:1703489,PMID:2401370,PMID:8002961 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.5.1.26
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
name: glycosylasparaginase, lysosomal
product: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000176
fast: false
is described by: ECO:0000000
reversible: false

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

metaM ksi deg15 l
is: SBO:0000247
is: HMDB00143
name: keratan sulfate I, degradation product 15
initial amount: NaN
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C160H257N11O140S8 CHARGE: -8
has only substance units: false
is: CHEBI:12936

http://identifiers.org/biomodels.db/MODEL1310110022#_0ee8297b_d44c_409f_b5c2_c0279f6c23b1
boundary condition: true
constant: false
is: Q9UFY1
type: Species
is encoded by: hsa:5335
initial concentration: NaN
name: PLCG1
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaM taur c
is: C00245
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB00251
is: CHEBI:3544
type: Species
name: Taurine
initial concentration: 1.0
constant: false
notes: FORMULA: C2H7NO3S CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110022#_bf112d09_381b_4a43_a636_2c15bb3a85d6
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
is: P51178
has only substance units: false
is encoded by: hsa:5333
type: Species
name: PLCD1

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

metaM fadh2 m
boundary condition: false
name: Flavin adenine dinucleotide reduced
constant: false
initial concentration: 1.0
is: C01352
initial amount: NaN
is: HMDB01197
is: SBO:0000247
is: CHEBI:58307
has only substance units: false
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_dedeaeac_0b4c_41cf_a6ee_c1f3f65ff2db
boundary condition: true
name: QPRT
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:23475
is: Q15274
is: SBO:0000252
type: Species

metaR BUTt2r
name: Butyrate transport via proton symport, reversible
type: Reaction
fast: false
modifier: MODEL1310110022#
reactant: MODEL1310110022#
product: MODEL1310110022#
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110022#_17ac6b31_d347_41da_8e16_2ddb3e56d77c
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1339
initial concentration: NaN
constant: false
name: COX6A2
is: Q02221
type: Species
has only substance units: false
boundary condition: true

metaM prostgi2 c
initial amount: NaN
boundary condition: false
name: prostaglandin I2(1-)
type: Species
is: CHEBI:57403
is: HMDB01335
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312

metaM HC01609 e
constant: false
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
type: Species
name: UroporphyrinogenI
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28766

metaM dudp m
initial amount: NaN
is: HMDB01000
constant: false
name: dUDP(3-)
initial concentration: 1.0
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:60471

http://identifiers.org/biomodels.db/MODEL1310110022#_3a9b31f8_e233_44ec_8875_ac498ef2a5e0
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

metaR C4STMO2Pr
name: C-4 methyl sterol oxidase
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
reactant: MODEL1310110022#
fast: false
modifier: MODEL1310110022#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.170
is: SBO:0000176
reversible: false
is described by: ECO:0000000
product: MODEL1310110022#
kinetic law: MODEL1310110022#

metaR LTC4CP
kinetic law: MODEL1310110022#
is: SBO:0000176
name: Leukotriene C4 carboxypeptidase
product: MODEL1310110022#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_09e50a2a_cf0f_494e_9f3e_6b079a099cd7
name: SLC38A4
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:55089
initial concentration: NaN
is: Q969I6
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR CHOLATEt
is described by: ECO:0000269
fast: false
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
name: cholate transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
reactant: MODEL1310110022#
is: SBO:0000185
type: Reaction
product: MODEL1310110022#
reversible: true

metaM hs deg4 l
is: CHEBI:15748
is: SBO:0000247
name: heparan sulfate, degradation product 4
initial amount: NaN
boundary condition: false
notes: FORMULA: C73H104N4O92S10 CHARGE: -12
constant: false
has only substance units: false
is: HMDB00127
initial concentration: 1.0
type: Species

metaM docosdiac c
initial amount: NaN
constant: false
is: SBO:0000247
name: docosanedioicacid
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/244872
notes: FORMULA: C22H40O4 CHARGE: -2

metaR NACHEX21ly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
fast: false
product: MODEL1310110022#
reversible: false
reactant: MODEL1310110022#
modifier: MODEL1310110022#
is: SBO:0000176
kinetic law: MODEL1310110022#
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction

metaR GALASE10ly
name: beta-galactosidase, lysosomal
reversible: false
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5

metaM chol n
is: SBO:0000247
type: Species
initial amount: NaN
name: choline
is: HMDB00097
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
initial concentration: 1.0
is: CHEBI:15354
boundary condition: false
has only substance units: false
constant: false

metaR r2334
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110022#
fast: false
reactant: MODEL1310110022#
is described by: ECO:0000000
reversible: true
product: MODEL1310110022#

metaM pmtcoa x
is: SBO:0000247
is: C00154
is: HMDB01338
constant: false
has only substance units: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
boundary condition: false
type: Species
initial amount: NaN
name: Palmitoyl-CoA (n-C16:0CoA)
initial concentration: 1.0
is: CHEBI:57379

metaR r0512
product: MODEL1310110022#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
modifier: MODEL1310110022#
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
is: SBO:0000176
kinetic law: MODEL1310110022#
reversible: true
is version of: http://identifiers.org/ec-code/1.17.4.1
type: Reaction
reactant: MODEL1310110022#

metaM dadp m
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
name: dADP(3-)
is: HMDB01508
is: CHEBI:57667
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110022#_334614b7_68f9_4cc6_8ecf_0556b786b2a3
name: DGKE
type: Species
boundary condition: true
initial amount: NaN
is: A1L4Q0
is encoded by: hsa:8526
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false

metaM dudp n
is: HMDB01000
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
name: dUDP(3-)
is: CHEBI:60471
has only substance units: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
constant: false
boundary condition: false

metaR ECOAH1m
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
fast: false
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/4.2.1.18
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000304
reactant: MODEL1310110022#
is: SBO:0000176
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)

metaM inost c
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
has only substance units: false
boundary condition: false
is: HMDB00211
name: myo-inositol
is: SBO:0000247
constant: false
is: CHEBI:17268
type: Species
initial amount: NaN
initial concentration: 1.0

metaR KSII CORE4tly
fast: false
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110022#
name: keratan sulfate II (core 4) transport, extracellular to lysosome
type: Reaction
reversible: false
reactant: MODEL1310110022#
is described by: ECO:0000000
is: SBO:0000185

metaM lac D c
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: (R)-lactate
is: CHEBI:16004
is: HMDB01311
constant: false
type: Species
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1

metaR EX 5thf LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (THF) exchange
type: Reaction

metaR MECOAS1m
fast: false
type: Reaction
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
is version of: http://identifiers.org/ec-code/6.2.1.4
modifier: MODEL1310110022#
is described by: ECO:0000304
product: MODEL1310110022#
reversible: true
name: mesaconate--CoA ligase (GDP-forming)

http://identifiers.org/biomodels.db/MODEL1310110022#_fb25f7c3_dc4e_489a_a5f8_133930e905a0
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: PLCH2
is encoded by: hsa:9651
initial amount: NaN
type: Species
is: O75038
constant: false
boundary condition: true

metaR r2333
is: SBO:0000185
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110022#
fast: false
type: Reaction
reactant: MODEL1310110022#
product: MODEL1310110022#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR EX crm hs LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acylsphingosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_b0d94ec0_e1e2_4d1e_a8f8_4edd225bb64e
is: O14772
boundary condition: true
is: SBO:0000252
is encoded by: hsa:8790
has only substance units: false
initial amount: NaN
name: FPGT
initial concentration: NaN
constant: false
type: Species

metaR SPHMYLNtg
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
name: sphingomyelin intracellular transport
is described by: ECO:0000000
product: MODEL1310110022#
fast: false
reversible: true

metaM udpgal g
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: UDP-D-galactose(2-)
is: HMDB00302
is: CHEBI:58439
constant: false
type: Species
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
boundary condition: false

metaM dadp n
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:57667
name: dADP(3-)
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: HMDB01508

metaM asp L c
name: L-aspartate(1-)
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
has only substance units: false
is: HMDB00191
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:29991
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110022#_23cc234c_4e11_4283_adee_d887a724eb37
has only substance units: false
is encoded by: hsa:3295
constant: false
is: E9PB82
initial concentration: NaN
boundary condition: true
name: HSD17B4
initial amount: NaN
type: Species
is: SBO:0000252

metaR r1559
type: Reaction
reversible: true
product: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reactant: MODEL1310110022#
fast: false
kinetic law: MODEL1310110022#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110022#_7024b8eb_f4aa_4574_9bd7_ce26254fe818
type: Species
name: ALDH3A1
is: P30838
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:218
initial amount: NaN
has only substance units: false

metaR EX nac LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_e008b6d0_9bda_48ad_ad95_5fda2a9fe40c
boundary condition: true
has only substance units: false
name: HADHA
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3030
initial amount: NaN
constant: false
is: E9KL44
type: Species

metaM 3sala c
has only substance units: false
constant: false
is: C00606
is: SBO:0000247
type: Species
notes: FORMULA: C3H5NO4S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
name: 3-Sulfino-L-alanine
initial concentration: 1.0
is: CHEBI:61085
boundary condition: false
initial amount: NaN

metaM C04849 e
is: SBO:0000247
type: Species
is: CHEBI:57449
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849

metaM hs deg15 l
notes: FORMULA: C49H71N2O57S5 CHARGE: -7
name: heparan sulfate, degradation product 15
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB00127
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:15748

http://identifiers.org/biomodels.db/MODEL1310110022#_51247c06_c2b3_47f6_8087_bd788054ca33
is encoded by: hsa:AI631997
type: Species
has only substance units: false
initial concentration: NaN
name: _AI631997_1_m
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR CYTD
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (978.1) or (57379.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.5 Confidence Level: 2 AUTHORS: PMID:14744791,PMID:15087440,PMID:7923172,PMID:8001985,PMID:8422236 NOTES:
reactant: MODEL1310110022#
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
type: Reaction
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.5.4.5
name: cytidine deaminase
product: MODEL1310110022#
is: SBO:0000176

metaM ksii core2 deg2 l
is: SBO:0000247
type: Species
constant: false
is: CHEBI:12936
has only substance units: false
initial concentration: 1.0
name: keratan sulfate II (core 2-linked), degradation product 2
boundary condition: false
initial amount: NaN
notes: FORMULA: C70H114N5O56S2X CHARGE: -2
is: HMDB00143

http://identifiers.org/biomodels.db/MODEL1310110022#_21c8d624_efcd_4ea3_9a12_6f9a2013a144
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: GALNT9
constant: false
is: Q9HCQ5
has only substance units: false
initial concentration: NaN
is encoded by: hsa:50614
type: Species

metaR PSt3
reactant: MODEL1310110022#
name: phosphatidylserine transport
fast: false
product: MODEL1310110022#
kinetic law: MODEL1310110022#
is described by: ECO:0000269
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:

metaM prostgi2 e
initial amount: NaN
is: CHEBI:57403
is: SBO:0000247
is: HMDB01335
has only substance units: false
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
name: prostaglandin I2(1-)
type: Species
constant: false
initial concentration: 1.0

metaR r2332
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
kinetic law: MODEL1310110022#
is: SBO:0000185
fast: false
product: MODEL1310110022#
reactant: MODEL1310110022#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaM ksi deg16 l
initial amount: NaN
notes: FORMULA: C160H258N11O137S7 CHARGE: -7
initial concentration: 1.0
is: CHEBI:57455
is: SBO:0000247
constant: false
has only substance units: false
type: Species
boundary condition: false
is: HMDB01354
name: keratan sulfate I, degradation product 16

metaR NDPK1n
reactant: MODEL1310110022#
name: nucleoside-diphosphate kinase (ATP:GDP), nuclear
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
fast: false
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:15242782 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
is: SBO:0000176
is described by: ECO:0000134
type: Reaction

metaR EX spc hs LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: sphingosylphosphorylcholine (homo sapiens) exchange
type: Reaction

metaR CORE6GTg
reversible: false
type: Reaction
is: SBO:0000176
fast: false
name: Core 6 beta-GlcNAc-transferase A, Golgi apparatus
is described by: ECO:0000000
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (2650.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.102
modifier: MODEL1310110022#
reactant: MODEL1310110022#
product: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_21051510_b3f8_4822_95c9_7fedfa88fa50
initial concentration: NaN
has only substance units: false
name: GCNT1
type: Species
is encoded by: hsa:2650
boundary condition: true
is: SBO:0000252
constant: false
is: Q02742
initial amount: NaN

metaR DNDPt25m
modifier: MODEL1310110022#
product: MODEL1310110022#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dTDP transport via dCDP antiport
type: Reaction
kinetic law: MODEL1310110022#
reversible: false
fast: false
is: SBO:0000185
reactant: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_408d7f0a_c400_4e6e_90b5_aedac89c2231
is: O95992
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:9023
is: SBO:0000252
name: CH25H
has only substance units: false

metaR r1579
reversible: true
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
product: MODEL1310110022#
fast: false
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r0268
is described by: ECO:0000000
modifier: MODEL1310110022#
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
is version of: http://identifiers.org/ec-code/3.1.3.2
type: Reaction
kinetic law: MODEL1310110022#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.1
reactant: MODEL1310110022#
product: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_b79b90bb_9a75_44d4_97ea_a08bac8d732f
type: Species
has only substance units: false
is: SBO:0000252
name: CHAT
boundary condition: true
is: Q6LEN6
constant: false
initial amount: NaN
is encoded by: hsa:1103
initial concentration: NaN

metaR r1623
modifier: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
type: Reaction
product: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000185

metaM creat c
constant: false
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
initial amount: NaN
is: HMDB00064
name: creatine
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16919
boundary condition: false
type: Species
has only substance units: false

metaR VALTAm
modifier: MODEL1310110022#
is described by: ECO:0000269
fast: false
reversible: true
type: Reaction
name: valine transaminase, mitochondiral
is: SBO:0000176
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.6.1.42
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
product: MODEL1310110022#

metaM tsul e
is: SBO:0000247
constant: false
is: CHEBI:16094
boundary condition: false
name: thiosulfate(2-)
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
has only substance units: false
initial concentration: 1.0
is: HMDB00257
type: Species
initial amount: NaN

metaR UMPK5
reversible: true
fast: false
modifier: MODEL1310110022#
name: UMP kinase (dATP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110022#
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
kinetic law: MODEL1310110022#
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110022#_38c97df8_1fcd_44cf_a798_da578e63f263
constant: false
has part: P22392
boundary condition: true
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:4830
initial concentration: NaN
is encoded by: hsa:4831
name: NME1:NME2
has part: P15531
has only substance units: false
type: Species

metaM o2 x
boundary condition: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: SBO:0000247
has only substance units: false
name: O2
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB01377
is: CHEBI:15379
constant: false
is: C00007

metaR GALASE17ly
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
kinetic law: MODEL1310110022#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110022#
product: MODEL1310110022#
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4

metaR PCHOL HSter
reactant: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
name: phosphatidylcholine scramblase
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: true
product: MODEL1310110022#
kinetic law: MODEL1310110022#

metaM hs deg6 l
type: Species
is: HMDB01352
notes: FORMULA: C67H98N4O83S9 CHARGE: -10
is: SBO:0000247
name: heparan sulfate, degradation product 6
boundary condition: false
is: CHEBI:17180
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaM ncam e
is: HMDB01406
is: C00153
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: CHEBI:0
is: SBO:0000247
boundary condition: false
name: Nicotinamide
initial concentration: 1.0
notes: FORMULA: C6H6N2O CHARGE: 0

metaM lanost r
has only substance units: false
is: HMDB01251
name: lanosterol
initial amount: NaN
boundary condition: false
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00833 EHMN_ABBREVIATION: C01724
type: Species
initial concentration: 1.0
is: CHEBI:16521
constant: false
is: SBO:0000247

metaM sT antigen g
type: Species
is: SBO:0000247
is: CHEBI:16565
has only substance units: false
boundary condition: false
notes: FORMULA: C25H40N2O18X CHARGE: -1
name: sialyl-T antigen
constant: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110022#_658a8e53_4e0b_44f5_8d68_ecce17794c33
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
is: P30838
is: SBO:0000252
has only substance units: false
name: ALDH3A1
type: Species
is encoded by: hsa:218

metaR CHOLtn
is: SBO:0000185
product: MODEL1310110022#
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
name: Choline transport, nuclear through pores
reversible: true
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_1d308fd1_208f_432a_9304_eb26455ad469
type: Species
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
name: ALDH3B2
is encoded by: hsa:222
initial concentration: NaN
is: P48448
has only substance units: false

metaM taur e
is: CHEBI:3544
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
name: Taurine
is: HMDB00251
is: C00245
initial amount: NaN
notes: FORMULA: C2H7NO3S CHARGE: 0
constant: false
is: SBO:0000247

metaR r0470
reversible: true
type: Reaction
reactant: MODEL1310110022#
is: SBO:0000176
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
kinetic law: MODEL1310110022#
fast: false
is described by: ECO:0000000
product: MODEL1310110022#

metaR IPDPtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 5.3.3.2 Confidence Level: 1 AUTHORS: PMID:11111079 NOTES:
name: Isopentenyl diphosphate transport (peroxisome)
fast: false
kinetic law: MODEL1310110022#
type: Reaction
reactant: MODEL1310110022#
is described by: ECO:0000134
product: MODEL1310110022#
is: SBO:0000185
reversible: true

metaM uacgam r
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
initial concentration: 1.0
boundary condition: false
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
has only substance units: false
initial amount: NaN
type: Species
is: HMDB00290
constant: false
is: CHEBI:57705
is: SBO:0000247

metaR r1578
kinetic law: MODEL1310110022#
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110022#
is described by: ECO:0000000
type: Reaction

metaR r0267
is described by: ECO:0000000
modifier: MODEL1310110022#
type: Reaction
reversible: true
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
product: MODEL1310110022#
is: SBO:0000176
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
is version of: http://identifiers.org/ec-code/3.5.1.9
kinetic law: MODEL1310110022#
fast: false

metaR RE0830C
kinetic law: MODEL1310110022#
is: SBO:0000176
fast: false
is described by: ECO:0000000
product: MODEL1310110022#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
reactant: MODEL1310110022#
name: RE0830

metaM man c
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: C00159
initial amount: NaN
is: CHEBI:16024
name: D-Mannose
boundary condition: false
is: SBO:0000247
type: Species
constant: false
is: HMDB00169

metaM hs deg21 l
is: CHEBI:15748
initial concentration: 1.0
is: HMDB00127
type: Species
notes: FORMULA: C37H55NO38S2 CHARGE: -4
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
name: IdoA2S-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
has only substance units: false

metaR r1624
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110022#
product: MODEL1310110022#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#

metaR UMPK4
name: UMP kinase (GTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110022#
product: MODEL1310110022#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
kinetic law: MODEL1310110022#
reversible: true
modifier: MODEL1310110022#
fast: false
type: Reaction

metaM leu L c
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:15603
type: Species
name: L-leucine
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
initial concentration: 1.0
initial amount: NaN
is: HMDB00687
boundary condition: false

metaM retinal cis 9 c
name: all-trans-retinal
is: CHEBI:17898
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
boundary condition: false
is: HMDB01358
initial amount: NaN
is: SBO:0000247

metaR r2100
is: SBO:0000185
reversible: true
type: Reaction
modifier: MODEL1310110022#
product: MODEL1310110022#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reactant: MODEL1310110022#
is described by: ECO:0000000
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM mi134p c
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
is: HMDB01143
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)
is: SBO:0000247
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243
is: CHEBI:58414
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110022#_8f9c1c3c_6827_4cdc_863f_8d23bc2f5f33
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:5167
initial concentration: NaN
name: ENPP1
boundary condition: true
is: P22413
constant: false
is: SBO:0000252

metaR GALASE20ly
is version of: http://identifiers.org/ec-code/3.4.16.5
name: beta-galactosidase, lysosomal
product: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
kinetic law: MODEL1310110022#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110022#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4

metaR r1625
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
modifier: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110022#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110022#_324293c6_9db9_4810_82ee_7387175d9dbd
is encoded by: hsa:5332
name: PLCB4
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: E2QRH8
initial amount: NaN
has only substance units: false
type: Species

metaR UMPK3
is: SBO:0000176
modifier: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: UMP kinase (UTP)
product: MODEL1310110022#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
type: Reaction
kinetic law: MODEL1310110022#

metaM 10fthf6glu e
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:57454
is: SBO:0000247
name: 10-formyltetrahydrofolate-[Glu](6)
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1
is: HMDB00972
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110022#_81340a8a_1603_41a2_aae9_1c3a487e3f91
initial amount: NaN
is: SBO:0000252
constant: false
name: INPP5B
type: Species
is encoded by: hsa:3633
is: P32019
initial concentration: NaN
has only substance units: false
boundary condition: true

metaM ncam c
has only substance units: false
is: HMDB01406
is: C00153
initial amount: NaN
constant: false
type: Species
is: CHEBI:0
is: SBO:0000247
boundary condition: false
name: Nicotinamide
initial concentration: 1.0
notes: FORMULA: C6H6N2O CHARGE: 0

metaR NDPK1m
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
type: Reaction
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
kinetic law: MODEL1310110022#
reversible: true
is described by: ECO:0000254
modifier: MODEL1310110022#
reactant: MODEL1310110022#

metaR r0472
product: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
is: SBO:0000176
fast: false
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
reversible: true
is described by: ECO:0000000
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1

metaR r2101
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110022#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110022#

metaR r1626
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
is: SBO:0000185
modifier: MODEL1310110022#
product: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_23688d72_40fe_4f5a_b492_e1caca55866f
is encoded by: hsa:6888
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
is: P37837
is: SBO:0000252
name: TALDO1
constant: false

metaR UMPK2
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110022#
type: Reaction
is: SBO:0000176
name: UMP kinase (CTP)
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
kinetic law: MODEL1310110022#
reversible: true
reactant: MODEL1310110022#

metaM leu L e
is: HMDB00687
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: CHEBI:15603
type: Species
has only substance units: false
name: L-leucine

http://identifiers.org/biomodels.db/MODEL1310110022#_4d19d690_4c4b_422e_9685_278b65f8d4a0
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:9123
has only substance units: false
is: SBO:0000252
is: O15427
type: Species
initial concentration: NaN
name: SLC16A3

http://identifiers.org/biomodels.db/MODEL1310110022#_79ec2a7a_aff9_4ea5_b71a_d9141d85dcca
is: SBO:0000252
initial concentration: NaN
name: _AI620219_1_m
type: Species
boundary condition: true
is encoded by: hsa:AI620219
initial amount: NaN
has only substance units: false
constant: false

metaM cholp c
constant: false
initial concentration: 1.0
name: choline phosphate(1-)
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:295975

metaR IDOAASE3ly
is described by: ECO:0000000
kinetic law: MODEL1310110022#
reversible: false
reactant: MODEL1310110022#
modifier: MODEL1310110022#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.76
product: MODEL1310110022#
name: alpha-L-iduronidase, lysosomal

metaR r2102
reversible: true
modifier: MODEL1310110022#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
product: MODEL1310110022#
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR r1575
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
product: MODEL1310110022#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_ceacf11a_96ed_4220_aa21_0bb230bab41d
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:8277
is: SBO:0000252
has only substance units: false
is: B7Z7I0
boundary condition: true
name: TKTL1
initial concentration: NaN

metaR EX docosac
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Behenic acid
type: Reaction

metaR TALA
modifier: MODEL1310110022#
reactant: MODEL1310110022#
product: MODEL1310110022#
fast: false
name: transaldolase
is version of: http://identifiers.org/ec-code/2.2.1.2
type: Reaction
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
kinetic law: MODEL1310110022#
is described by: ECO:0000000
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110022#_a9f56cef_f660_4735_ad79_95826710b5f8
is: Q01581
name: HMGCS1
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:3157
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species

metaR RE0915E
reactant: MODEL1310110022#
modifier: MODEL1310110022#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.17
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.1
fast: false
is described by: ECO:0000000
reversible: true
name: RE0915
product: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_bfa13ed7_a064_4e3c_8207_7e6f15a30539
name: DCK
is: P27707
type: Species
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:1633
has only substance units: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_e4ff44f4_cccb_4042_8610_afaf20a10e73
has only substance units: false
type: Species
name: AQP8
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is: O94778
is encoded by: hsa:343
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110022#_f792f852_e3cf_40d4_9b92_d4f914d2c047
initial concentration: NaN
has only substance units: false
boundary condition: true
name: PEMT
is encoded by: hsa:10400
type: Species
is: SBO:0000252
constant: false
initial amount: NaN

metaM xylt e
constant: false
is: CHEBI:17151
type: Species
is: HMDB02917
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
initial concentration: 1.0
name: xylitol
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110022#_671f9c51_c3ce_441d_ad38_b7e1ff816f33
name: GMPR2
is: Q86T14
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:51292
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_d9a91d35_7ef8_4639_b606_033c6e52efad
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
is: Q9Y2Q0
name: ATP8A1
is encoded by: hsa:10396

metaR XANDp
fast: false
kinetic law: MODEL1310110022#
type: Reaction
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.17.1.4
product: MODEL1310110022#
reversible: false
is: SBO:0000176
is described by: ECO:0000269
name: xanthine dehydrogenase, peroxisomal
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Purine catabolism EC Number: 1.1.1.204 Confidence Level: 4 AUTHORS: PMID:12637268,PMID:8670112 NOTES:Acts on a variety of purines and aldehydes. The animal enzyme can be interconverted to EC 1.1.3.22 xanthine oxidase (the oxidase form). IT

metaM 2mcit e
is: HMDB00379
name: 2-methylcitrate(3-)
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:15598
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C7H7O7 CHARGE: -3 INCHI: InChI=1S/C7H10O7/c1-3(5(10)11)7(14,6(12)13)2-4(8)9/h3,14H,2H2,1H3,(H,8,9)(H,10,11)(H,12,13)/p-3

metaM adp c
type: Species
is: C00008
is: CHEBI:16761
is: http://identifiers.org/pubchem.compound/3310
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB01341
constant: false
initial concentration: 1.0
name: ADP

metaM ha pre1 e
type: Species
is: CHEBI:16126
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: hyaluronan biosynthesis, precursor 1

metaR r2103
reactant: MODEL1310110022#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reversible: true
product: MODEL1310110022#
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
type: Reaction

metaR r0321
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
modifier: MODEL1310110022#
is described by: ECO:0000000
kinetic law: MODEL1310110022#
fast: false
reactant: MODEL1310110022#
product: MODEL1310110022#
reversible: false
is version of: http://identifiers.org/ec-code/6.3.5.2
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
type: Reaction

metaR FATP2t
fast: false
is: SBO:0000185
is described by: ECO:0000269
reversible: true
name: fatty acid electroneutral transport
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
product: MODEL1310110022#
type: Reaction
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
reactant: MODEL1310110022#

metaR DHCR241r
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.72
type: Reaction
reversible: false
product: MODEL1310110022#
is described by: ECO:0000134
reactant: MODEL1310110022#
name: 24-dehydrocholesterol reductase [Precursor]
kinetic law: MODEL1310110022#
is: SBO:0000176
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ

metaM hdca c
initial concentration: 1.0
constant: false
boundary condition: false
name: palmitate
initial amount: NaN
has only substance units: false
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: CHEBI:7896
is: HMDB00220
type: Species
is: SBO:0000247

metaM sTn antigen g
is: C00459
is: SBO:0000247
initial amount: NaN
is: CHEBI:37568
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
name: sialyl-Tn antigen
is: HMDB01342
constant: false
notes: FORMULA: C19H30N2O13X CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110022#_ed770155_72c5_4bc1_bfec_052cb887e99a
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
is: Q92536
name: SLC7A6
is encoded by: hsa:9057
initial concentration: NaN
has only substance units: false

metaR r1574
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110022#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000

metaR 1PPDCRp
product: MODEL1310110022#
fast: false
reactant: MODEL1310110022#
is described by: ECO:0000000
name: delta1-piperideine-2-carboxylate reductase, perixosomal
type: Reaction
kinetic law: MODEL1310110022#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110022#_e996b5e1_b821_4128_bb6c_667135f2193d
initial concentration: NaN
name: CYP27A1
initial amount: NaN
constant: false
is: SBO:0000252
is: Q02318
type: Species
is encoded by: hsa:1593
has only substance units: false
boundary condition: true

metaR r1492
fast: false
name: Utilized transport
reactant: MODEL1310110022#
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110022#
is: SBO:0000185
reversible: false

metaM o2 r
is: SBO:0000247
constant: false
is: CHEBI:15379
has only substance units: false
is: HMDB01377
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial concentration: 1.0
name: O2
is: C00007
type: Species
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_a760a1a5_02d5_4fc6_ac0e_443b7f131d1a
name: NDUFB5
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is: O43674
is encoded by: hsa:4711

http://identifiers.org/biomodels.db/MODEL1310110022#_24024042_343a_4aee_bbd3_5f18f665a580
name: DGKG
is: P49619
boundary condition: true
is encoded by: hsa:1608
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_1fdc4cca_de8b_4cf3_b548_ae188aa87976
is encoded by: hsa:X63359
initial amount: NaN
name: _X63359_1_c
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false

metaM HC01115 c
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:29025
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
name: NeuNGc
has only substance units: false

metaR ACHEe
is version of: http://identifiers.org/ec-code/3.1.1.7
reactant: MODEL1310110022#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES:NJ
kinetic law: MODEL1310110022#
is described by: ECO:0000269
modifier: MODEL1310110022#
reversible: false
name: Acetylcholinesterase
type: Reaction
product: MODEL1310110022#

metaM fol e
notes: FORMULA: C19H18N7O6 CHARGE: -1
is: SBO:0000247
constant: false
is: HMDB00121
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: Folate
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_ba0d060a_4053_48fa_acdf_f44aadcfda37
has only substance units: false
initial concentration: NaN
type: Species
name: RDH16
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:8608
is: SBO:0000252
is: O75452

metaR NACHEX18ly
fast: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110022#
is described by: ECO:0000000
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
modifier: MODEL1310110022#
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#

metaR r1620
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110022#
fast: false
modifier: MODEL1310110022#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185

metaR H2O2tp
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110022#
kinetic law: MODEL1310110022#
fast: false
name: hydrogen peroxide peroxisomal transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
reactant: MODEL1310110022#

metaM hs deg14 l
notes: FORMULA: C57H84N3O62S5 CHARGE: -7
type: Species
is: CHEBI:15748
has only substance units: false
initial concentration: 1.0
is: HMDB00127
constant: false
is: SBO:0000247
boundary condition: false
name: heparan sulfate, degradation product 14
initial amount: NaN

metaM fucgalacglcgalgluside hs g
boundary condition: false
notes: FORMULA: C50H89N2O26FULLRCO CHARGE: 0
name: Type IH glycolipid
is: CHEBI:0
type: Species
initial concentration: 1.0
is: C00013
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB00250
has only substance units: false

metaR CHOLtg
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110022#
type: Reaction
name: choline intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110022#_5d8bb064_6b33_4cf9_95dc_b7971cb1ef0f
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:8639
is: Q16853
name: AOC3
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
type: Species

metaR CYTK14
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
fast: false
type: Reaction
product: MODEL1310110022#
kinetic law: MODEL1310110022#
name: cytidylate kinase (dCMP,UTP)
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110022#
modifier: MODEL1310110022#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110022#_126fb7c1_0d3e_4a98_8b71_b2f58e7f420f
is: A8K3J4
initial concentration: NaN
is encoded by: hsa:23632
type: Species
name: CA14
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_17ada6ab_7323_4e1d_a582_6300a0aca099
is encoded by: hsa:55902
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: Q5QPH3
type: Species
name: ACSS2
constant: false
initial concentration: NaN

metaR NAGLCAly
is described by: ECO:0000000
is: SBO:0000176
name: N-acetylglucosaminidase, lysosomal
type: Reaction
reversible: false
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 1 AUTHORS: NOTES:EC 3.2.1.- This reaction is my best guess at how the GlcNAc-beta-1,6-GalNAc linkage is cleaved. NCD
product: MODEL1310110022#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110022#_a5e86cd3_bb3b_42fa_b0dd_f334ca2dfaa4
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:641649
is: SBO:0000252
initial amount: NaN
is: C9JZ62
has only substance units: false
name: TMEM91
constant: false

metaR DCK1n
reversible: true
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.7.1.74
modifier: MODEL1310110022#
is described by: ECO:0000269
name: Deoxycytidine kinase, nuclear (ATP)
kinetic law: MODEL1310110022#
is: SBO:0000176
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_20acaff4_6a89_4962_ae55_b783115278a9
is: SBO:0000252
name: SLC38A5
is: Q8WUX1
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:92745

http://identifiers.org/biomodels.db/MODEL1310110022#_da854d29_bba7_4cb4_b5e9_b062bab9feeb
name: _AI373818_1_m
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
boundary condition: true
is encoded by: hsa:AI373818
has only substance units: false

metaR ATPtx
is described by: ECO:0000000
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
kinetic law: MODEL1310110022#
product: MODEL1310110022#
name: ATP transporter, peroxisomal
type: Reaction
reactant: MODEL1310110022#
fast: false

metaM xylt c
has only substance units: false
constant: false
type: Species
is: CHEBI:17151
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
initial concentration: 1.0
is: HMDB02917
is: SBO:0000247
name: xylitol
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_c73baacf_736c_441b_9ebf_a238b4fe496d
initial amount: NaN
has only substance units: false
is encoded by: hsa:1103
name: CHAT
type: Species
is: SBO:0000252
is: Q6LEN5
initial concentration: NaN
constant: false
boundary condition: true

metaR UMPK7
fast: false
reversible: true
modifier: MODEL1310110022#
name: UMP kinase (dGTP)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
product: MODEL1310110022#
type: Reaction
is: SBO:0000176

metaR r2104
reactant: MODEL1310110022#
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
product: MODEL1310110022#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110022#_df8abd11_8513_4c6e_9aaa_01502d1cbccb
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
name: HAO1
is: Q9UJM8
is: SBO:0000252
is encoded by: hsa:54363
type: Species

metaR r1621
is described by: ECO:0000000
modifier: MODEL1310110022#
is: SBO:0000185
reversible: true
product: MODEL1310110022#
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
reactant: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110022#_75f951ef_72ab_4cf3_a3af_0753c865d24a
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
is: O60760
has only substance units: false
initial amount: NaN
constant: false
name: HPGDS
is encoded by: hsa:27306

http://identifiers.org/biomodels.db/MODEL1310110022#_45040e1c_3383_47ec_a530_d620fc27ebd1
name: BLVRA
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: P53004
is encoded by: hsa:644
is: SBO:0000252
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_ac57f1ab_84de_43f6_b79b_0b31dda9ffc9
name: SLC16A8
is encoded by: hsa:23539
is: O95907
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110022#_8f6e19c4_9196_447f_9778_6748f898f189
constant: false
type: Species
name: SPHK2
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:56848
is: Q9NRA0

metaR S2TASE1ly
is version of: http://identifiers.org/ec-code/3.1.6.13
fast: false
type: Reaction
reversible: false
modifier: MODEL1310110022#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110022#
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
name: iduronate-2-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110022#_49582cc2_dd3d_4539_9f5a_099726141ec8
constant: false
is: SBO:0000252
initial concentration: NaN
name: GALNT2
boundary condition: true
is encoded by: hsa:2590
initial amount: NaN
has only substance units: false
is: Q10471
type: Species

metaR GGH 6THFe
name: Gamma-glutamyl hydrolase (6THF), extracellular
reversible: false
is: SBO:0000176
reactant: MODEL1310110022#
modifier: MODEL1310110022#
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.4.19.9
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is described by: ECO:0000000
kinetic law: MODEL1310110022#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_eac949ff_14eb_4ddb_9a4b_9fa2b6c3ef28
type: Species
name: CMA1
initial amount: NaN
constant: false
is: SBO:0000252
is: Q4FEB3
initial concentration: NaN
is encoded by: hsa:1215
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110022#_abda6e5e_c29e_403f_81ed_df09ff11ca01
is: SBO:0000252
name: GGH
constant: false
is: Q92820
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8836
initial amount: NaN
has only substance units: false
type: Species

metaR UMPK6
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110022#
is: SBO:0000176
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reversible: true
modifier: MODEL1310110022#
name: UMP kinase (dCTP)
fast: false

metaR r2105
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110022#
reversible: true
product: MODEL1310110022#
fast: false
reactant: MODEL1310110022#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110022#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR r1622
is described by: ECO:0000000
fast: false
product: MODEL1310110022#
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110022#
modifier: MODEL1310110022#
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

metaR r1576
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110022#
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110022#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110022#

metaR r0853
product: MODEL1310110022#
reversible: false
reactant: MODEL1310110022#
name: Facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8132483 NOTES:
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110022#
fast: false
type: Reaction

metaM HC00718 c
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57781
name: N-methylethanolaminium phosphate(1-)

http://identifiers.org/biomodels.db/MODEL1310110022#_9e482499_67e3_4be8_a297_15d8d2a8ccf0
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is encoded by: hsa:84002
initial amount: NaN
name: B3GNT5
boundary condition: true
is: SBO:0000252
is: Q9BYG0

metaR r1844
product: MODEL1310110022#
modifier: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000185
reversible: false
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110022#_376753eb_338e_4023_bad3_07392ff36c1e
type: Species
is: SBO:0000252
constant: false
name: GNS
has only substance units: false
is: Q7Z3X3
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2799
initial amount: NaN

metaR RETt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
type: Reaction
reactant: MODEL1310110022#
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110022#
reversible: false
kinetic law: MODEL1310110022#
name: Retinol transport via faciliated diffusion

metaR r2106
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110022#
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
reversible: true
reactant: MODEL1310110022#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

metaR SPODM
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000269
type: Reaction
fast: false
modifier: MODEL1310110022#
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.15.1.1
name: superoxide dismutase

http://identifiers.org/biomodels.db/MODEL1310110022#_7c1bc077_dc79_480c_a018_a9204a08dd97
type: Species
constant: false
initial concentration: NaN
name: ACP5
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:54
has only substance units: false
is: P13686

http://identifiers.org/biomodels.db/MODEL1310110022#_0eb33676_aa80_4b53_9560_13fb37fde70f
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:9374
name: PPT2
has only substance units: false
type: Species
is: Q9UMR5
boundary condition: true
initial concentration: NaN

metaM man l
initial concentration: 1.0
type: Species
name: D-mannose
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:16024
is: HMDB00169
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159

metaR C3STKR2r
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
reversible: false
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER - NJ
is described by: ECO:0000134
is: SBO:0000176
reactant: MODEL1310110022#
name: C-3 sterol keto reductase (zymosterol)
kinetic law: MODEL1310110022#
product: MODEL1310110022#
fast: false

metaM dudp c
is: SBO:0000247
is: CHEBI:60471
initial concentration: 1.0
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: HMDB01000
is: C01346
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
name: dUDP
type: Species

metaR r0196
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
fast: false
is described by: ECO:0000000
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
reactant: MODEL1310110022#
product: MODEL1310110022#
reversible: true
kinetic law: MODEL1310110022#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.5
type: Reaction

metaR r1571
kinetic law: MODEL1310110022#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110022#
reversible: true

metaM glyald m
initial concentration: 1.0
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
is: HMDB01051
type: Species
boundary condition: false
has only substance units: false
name: D-glyceraldehyde
is: SBO:0000247
is: CHEBI:17378
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_c7e44494_0ef6_46eb_ba7d_de98eefa7f25
is encoded by: hsa:1892
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
name: ECHS1
type: Species
boundary condition: true
is: P30084
is: SBO:0000252

metaR r2107
modifier: MODEL1310110022#
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
product: MODEL1310110022#
type: Reaction
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#

metaR CYANt
reversible: true
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
is: SBO:0000185
fast: false
name: Cyanide transport via diffusion (extracellular to cytosol)
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM
type: Reaction
product: MODEL1310110022#

metaM k c
is: SBO:0000247
is: CHEBI:29103
is: C00238
constant: false
initial amount: NaN
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
type: Species
initial concentration: 1.0
name: potassium
has only substance units: false
is: HMDB00586
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110022#_b1ae6d7e_9164_42ec_993f_613f0d889c50
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:197257
name: LDHD
has only substance units: false
is: SBO:0000252
constant: false

metaM o2 n
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: O2 CHARGE: 0 INCHI: InChI=1S/O2/c1-2 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
has only substance units: false
is: HMDB01377
constant: false
name: dioxygen
initial amount: NaN
is: CHEBI:15379

metaM ksi deg1 l
has only substance units: false
constant: false
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
initial amount: NaN
initial concentration: 1.0
name: keratan sulfate I, degradation product 1
boundary condition: false
is: CHEBI:18287
is: SBO:0000247
is: HMDB00174
type: Species

metaM thbpt c
initial amount: NaN
has only substance units: false
is: HMDB00027
boundary condition: false
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:15372
name: 5,6,7,8-tetrahydrobiopterin

metaR NCNt
is described by: ECO:0000269
kinetic law: MODEL1310110022#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
fast: false
product: MODEL1310110022#
modifier: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000185
name: Na+/Ca2+-NH4+ exchange

http://identifiers.org/biomodels.db/MODEL1310110022#_01d853b4_06ff_4c90_99c1_af7718e89d0e
initial concentration: NaN
constant: false
name: CMPK1
initial amount: NaN
type: Species
is: B2R6S5
is encoded by: hsa:51727
has only substance units: false
is: SBO:0000252
boundary condition: true

metaM dolglcp L c
has only substance units: false
boundary condition: false
is: CHEBI:15812
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
type: Species
is: SBO:0000247
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
initial amount: NaN
initial concentration: 1.0
constant: false

metaR r1570
is described by: ECO:0000000
reversible: true
product: MODEL1310110022#
type: Reaction
fast: false
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110022#_0471d438_c96d_4187_acc0_a51f1ddc8bc6
type: Species
is encoded by: hsa:8867
is: C9JFZ1
is: SBO:0000252
boundary condition: true
name: SYNJ1
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_0f8fecf2_9927_471a_bf50_557ee0d288ad
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:53354
name: PANK1
initial concentration: NaN
is: Q8TE04
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_8077d738_41df_43ac_8809_b9144e94c3f8
boundary condition: true
type: Species
name: NT5C2
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:22978
has only substance units: false
is: P49902

metaM 2mcit c
type: Species
initial concentration: 1.0
is: CHEBI:15598
notes: FORMULA: C7H7O7 CHARGE: -3 INCHI: InChI=1S/C7H10O7/c1-3(5(10)11)7(14,6(12)13)2-4(8)9/h3,14H,2H2,1H3,(H,8,9)(H,10,11)(H,12,13)/p-3
has only substance units: false
name: 2-methylcitrate(3-)
constant: false
is: HMDB00379
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaR r2108
kinetic law: MODEL1310110022#
reversible: true
product: MODEL1310110022#
fast: false
modifier: MODEL1310110022#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110022#

metaM hs deg2 l
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C79H116N5O96S10 CHARGE: -11
is: CHEBI:17180
initial amount: NaN
name: heparan sulfate, degradation product 2
boundary condition: false
has only substance units: false
is: HMDB01352
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_a8478402_2269_4f73_b190_b4be42875e2a
has only substance units: false
type: Species
is: SBO:0000252
name: CA8
is: P35219
constant: false
boundary condition: true
is encoded by: hsa:767
initial concentration: NaN
initial amount: NaN

metaR S6TASE11ly
is version of: http://identifiers.org/ec-code/3.1.6.14
name: N-acetylglucosamine-6-sulfatase, lysosomal
is: SBO:0000176
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
fast: false
reactant: MODEL1310110022#
modifier: MODEL1310110022#
product: MODEL1310110022#
is described by: ECO:0000000
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110022#_b7c38cf3_2874_4235_93b7_47c1a931cf9a
has only substance units: false
is: Q9UGH3
initial amount: NaN
is encoded by: hsa:9962
constant: false
type: Species
boundary condition: true
name: SLC23A2
is: SBO:0000252
initial concentration: NaN

metaR 5ADTSTSTERONEte
product: MODEL1310110022#
reversible: true
reactant: MODEL1310110022#
is described by: ECO:0000000
name: 5 alpha dihydrotesterone transport
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
kinetic law: MODEL1310110022#
fast: false

metaR EX ins LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Inosine exchange
type: Reaction

metaR r1573
fast: false
is: SBO:0000185
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110022#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110022#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110022#_1981d8b2_74b0_438e_ac5b_5a3a1dc3277c
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:4597
is: P53602
type: Species
initial concentration: NaN
boundary condition: true
name: MVD
initial amount: NaN

metaR TDCHOLAtx
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
name: bile acid intracellular transport
type: Reaction
reactant: MODEL1310110022#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110022#

metaM 2mop c
constant: false
is: HMDB01172
name: 2-methyl-3-oxopropanoate
is: CHEBI:57700
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
type: Species

metaR S6TASE13ly
reactant: MODEL1310110022#
product: MODEL1310110022#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.14
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is: SBO:0000176
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110022#
name: N-acetylglucosamine-6-sulfatase, lysosomal

metaR r2109
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110022#
modifier: MODEL1310110022#
is described by: ECO:0000000
kinetic law: MODEL1310110022#
type: Reaction
product: MODEL1310110022#
fast: false
reversible: true
is: SBO:0000185

metaM leu L m
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB00687
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
type: Species
is: CHEBI:15603
has only substance units: false
is: SBO:0000247
name: L-leucine
boundary condition: false

metaR CHOLtu
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
modifier: MODEL1310110022#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110022#
name: Choline uniport
fast: false

http://identifiers.org/biomodels.db/MODEL1310110022#_caa62670_7fc9_45f0_b214_b2816b1f3417
is: SBO:0000252
has only substance units: false
constant: false
name: SLC6A9
type: Species
initial concentration: NaN
is encoded by: hsa:6536
boundary condition: true
initial amount: NaN
is: B7Z3W8

http://identifiers.org/biomodels.db/MODEL1310110022#_51a3bb0a_1f9e_495f_a148_5236700811fb
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:53354
boundary condition: true
name: PANK1
is: Q8TE04
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110022#_b94c900c_91d0_4a1a_b0e0_d49b5d1584dc
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:1109
name: AKR1C4
boundary condition: true
is: SBO:0000252
is: P17516
initial amount: NaN

metaM fol c
has only substance units: false
notes: FORMULA: C19H18N7O6 CHARGE: -1
initial concentration: 1.0
name: Folate
initial amount: NaN
is: SBO:0000247
is: HMDB00121
type: Species
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_165eb3ff_4d0d_40cb_bb56_348e725186db
name: _AI934540_1_c
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AI934540
constant: false
is: SBO:0000252

metaR ADSK
product: MODEL1310110022#
modifier: MODEL1310110022#
is described by: ECO:0000269
reversible: false
is: SBO:0000176
type: Reaction
name: adenylyl-sulfate kinase
kinetic law: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.25
reactant: MODEL1310110022#

metaR EX leuktrA4 LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene A4 exchange
type: Reaction

metaM apoC c
constant: false
boundary condition: false
name: Apocarboxlase (no lys residue)
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:16032
is: HMDB00031
notes: FORMULA: XH CHARGE: 0
initial amount: NaN
initial concentration: 1.0

metaR DHORTS
modifier: MODEL1310110022#
fast: false
kinetic law: MODEL1310110022#
name: dihydroorotase
product: MODEL1310110022#
type: Reaction
reactant: MODEL1310110022#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 3.5.2.3 Confidence Level: 4 AUTHORS: PMID:2565865,PMID:8619816 NOTES:
is version of: http://identifiers.org/ec-code/2.1.3.2
reversible: true
is: SBO:0000176

metaR ADSS
fast: false
is version of: http://identifiers.org/ec-code/6.3.4.4
name: adenylosuccinate synthase
product: MODEL1310110022#
type: Reaction
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
is described by: ECO:0000134
reversible: false
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
modifier: MODEL1310110022#
is: SBO:0000176

metaR SIAASE3ly
modifier: MODEL1310110022#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
product: MODEL1310110022#
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
name: sialidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.1.6.4

metaM 10fthf6glu c
initial amount: NaN
boundary condition: false
type: Species
name: 10-formyltetrahydrofolate-[Glu](6)
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110022#_7f241cdb_00ee_4b9f_8218_bbc36f1ab966
is encoded by: hsa:3073
is: SBO:0000252
name: HEXA
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is: P06865

metaR r1627
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110022#
fast: false
product: MODEL1310110022#
kinetic law: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

metaM ibcoa m
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB01243
is: SBO:0000247
constant: false
name: isobutyryl-CoA(4-)
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,34-35H,5-10H2,1-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00462 EHMN_ABBREVIATION: C00630
initial amount: NaN
is: CHEBI:57338
type: Species

metaM orn m
is: SBO:0000247
has only substance units: false
boundary condition: false
name: Ornithine
is: CHEBI:46912
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB00214
type: Species
is: C01602
notes: FORMULA: C5H13N2O2 CHARGE: 1

metaR r1628
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
reactant: MODEL1310110022#
product: MODEL1310110022#
reversible: true
fast: false

metaR NACHEX16ly
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
product: MODEL1310110022#
type: Reaction
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110022#_12b58f33_2218_40e8_9208_e6f4b3c12722
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
name: PEMT
is: SBO:0000252
is encoded by: hsa:10400
initial amount: NaN
type: Species
is: Q9UBM1

metaR DIDPtn
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
is described by: ECO:0000000
product: MODEL1310110022#
kinetic law: MODEL1310110022#
name: dIDP nuclear transport
reactant: MODEL1310110022#
reversible: true
is: SBO:0000185

metaR CYTK4n
is: SBO:0000176
name: cytidylate kinase (dCMP,GTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110022#
is described by: ECO:0000269
modifier: MODEL1310110022#
fast: false
reactant: MODEL1310110022#
product: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_35923264_b18d_47c8_a1ea_ec079652777c
name: SLC5A7
is: SBO:0000252
constant: false
has only substance units: false
is: Q9GZV3
is encoded by: hsa:60482
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species

metaM dgchol c
is: SBO:0000247
name: glycochenodeoxycholate
boundary condition: false
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
is: HMDB00637
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:36252
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_4d82506d_559f_48c3_9c06_a3a810df129b
name: ENTPD8
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:377841
initial amount: NaN
is: Q5MY95
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_66063330_7d50_496d_9446_996ce067e221
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
name: ALDOA
is: SBO:0000252
is encoded by: hsa:226
has only substance units: false
boundary condition: true

metaR r0193
reactant: MODEL1310110022#
type: Reaction
kinetic law: MODEL1310110022#
is described by: ECO:0000000
reversible: true
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
is: SBO:0000176
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
fast: false

metaM leuktrF4 e
has only substance units: false
type: Species
initial amount: NaN
is: HMDB06465
initial concentration: 1.0
is: CHEBI:27491
is: SBO:0000247
name: leukotriene F4
constant: false
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
boundary condition: false

metaM leuktrA4 e
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
name: leukotriene A4(1-)
is: HMDB01337
boundary condition: false
is: CHEBI:57463
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
initial amount: NaN

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_888e67d8_1695_4449_9b0b_46cd8a8633f8
constant: false
name: CHAT
initial concentration: NaN
is: Q6LEN5
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:1103
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_6b8dfbff_38b3_498f_8a02_d3776331d07e
name: SLC36A1
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:206358
is: Q1LZ56
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

metaR UMPK2n
is described by: ECO:0000269
fast: false
is: SBO:0000176
name: UMP kinase (CTP),nuclear
reversible: true
modifier: MODEL1310110022#
reactant: MODEL1310110022#
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
kinetic law: MODEL1310110022#

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

metaR r1629
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110022#
product: MODEL1310110022#

metaM creat e
is: CHEBI:16919
is: HMDB00064
boundary condition: false
name: creatine
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
initial concentration: 1.0

metaR r0113
is version of: http://identifiers.org/ec-code/6.2.1.1
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 0 AUTHORS: PMID:10431835,PMID:15748884,PMID:3740419,PMID:4337336,PMID:5063602,PMID:5417402,PMID:9305887,PMID:9305888 NOTES:
is: SBO:0000176
reactant: MODEL1310110022#
type: Reaction
name: UDP-N-acetyl-D-glucosamine 2-epimerase Aminosugars metabolism EC:5.1.3.14
product: MODEL1310110022#
kinetic law: MODEL1310110022#
reversible: false
fast: false
is described by: ECO:0000000
modifier: MODEL1310110022#

metaM tsul c
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:16094
is: HMDB00257
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
initial amount: NaN
has only substance units: false
boundary condition: false
name: thiosulfate(2-)

metaM malcoa c
is: CHEBI:57384
is: C00083
has only substance units: false
initial amount: NaN
is: HMDB01175
constant: false
initial concentration: 1.0
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
is: SBO:0000247
name: Malonyl-CoA
boundary condition: false
type: Species

metaM HC01672 c
name: Acetyl adenylate
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C12H15N5O8P CHARGE: -1 INCHI: InChI=1S/C12H16N5O8P/c1-5(18)25-26(21,22)23-2-6-8(19)9(20)12(24-6)17-4-16-7-10(13)14-3-15-11(7)17/h3-4,6,8-9,12,19-20H,2H2,1H3,(H,21,22)(H2,13,14,15)/t6-,8-,9-,12-/m1/s1 EHMN_ABBREVIATION: C05993
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
is: CHEBI:37666

metaR r0475
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
is: SBO:0000176
reactant: MODEL1310110022#
product: MODEL1310110022#
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110022#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_3dcb81f1_a355_4a05_bbaf_661e8ce3e53a
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
constant: false
name: BDH1
is encoded by: hsa:622
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_404d7e35_03ba_4518_b096_eb424f4161a3
is encoded by: hsa:11001
is: O14975
initial amount: NaN
has only substance units: false
boundary condition: true
name: SLC27A2
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false

metaM adp m
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:456216
name: ADP
constant: false
is: C00008
initial concentration: 1.0
is: HMDB01341
has only substance units: false
is: http://identifiers.org/pubchem.compound/3310
is: SBO:0000247

metaM o2 m
type: Species
initial concentration: 1.0
name: O2
is: CHEBI:15379
boundary condition: false
constant: false
is: HMDB01377
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: C00007

metaR RE0830N
is described by: ECO:0000000
reversible: true
product: MODEL1310110022#
name: RE0830
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/4.2.1.96
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
modifier: MODEL1310110022#
is: SBO:0000176
reactant: MODEL1310110022#
fast: false
type: Reaction

metaM prostge1 e
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
boundary condition: false
initial amount: NaN
is: HMDB01442
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:57397
type: Species
name: prostaglandin E1(1-)

metaM k e
has only substance units: false
initial concentration: 1.0
name: potassium
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
is: C00238
type: Species
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
is: HMDB00586
is: CHEBI:29103

metaM dgchol e
is: SBO:0000247
is: HMDB00637
boundary condition: false
constant: false
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
name: glycochenodeoxycholate
is: CHEBI:36252
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species

metaR B3GNT39g
modifier: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
reversible: false
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
is: SBO:0000176
fast: false

metaM ksii core2 deg5 l
is: CHEBI:12936
name: keratan sulfate II (core 2-linked), degradation product 5
is: HMDB00143
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C50H82N4O38SX CHARGE: -1
type: Species
initial concentration: 1.0

metaR CHATn
reactant: MODEL1310110022#
product: MODEL1310110022#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.6
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
name: Choline O-acetyltransferase
modifier: MODEL1310110022#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110022#_4deb0c9b_2098_4def_9a5b_93a9fdc18aad
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is encoded by: hsa:60490
is: SBO:0000252
is: Q96CD2
name: PPCDC
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110022#_da1588e0_82f6_4d7e_a6e1_49cd80aa43a7
initial concentration: NaN
initial amount: NaN
name: ALDH9A1
is encoded by: hsa:223
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
is: P49189

metaR ETOHt
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: NOTES:NCD
fast: false
is: SBO:0000185
product: MODEL1310110022#
name: ethanol reversible transport
type: Reaction
reversible: true
is described by: ECO:0000000

metaR EX retinol 9 cis LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 9-cis-retinol exchange
type: Reaction

metaR r0191
reversible: false
is: SBO:0000176
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (7915.1) or (9856.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275,PMID:4276999 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.24
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
name: UTP:D-fructose-6-phosphate 1-phosphotransferase EC:2.7.1.11

http://identifiers.org/biomodels.db/MODEL1310110022#_f5df76da_19b3_44f3_8760_9c17694ddf7d
is: Q16836
has only substance units: false
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: HADH
is encoded by: hsa:3033

metaM leuktrF4 c
is: HMDB06465
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
boundary condition: false
is: CHEBI:27491
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
name: leukotriene F4
type: Species

metaM leuktrA4 c
initial concentration: 1.0
is: SBO:0000247
name: leukotriene A4(1-)
constant: false
type: Species
boundary condition: false
is: CHEBI:57463
is: HMDB01337
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
has only substance units: false
initial amount: NaN

metaM adp n
name: ADP(3-)
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:456216
is: HMDB01341
initial concentration: 1.0
constant: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008

metaR GLXtp
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
is: SBO:0000185
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
is described by: ECO:0000000
name: glyoxylate transport, peroxisomal

metaM btn c
has only substance units: false
boundary condition: false
name: Biotin
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: HMDB00030
is: CHEBI:3420
constant: false
is: C00120
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_feb721b6_03bf_4256_9bba_07b6c2bc4adf
is: Q13057
name: COASY
is encoded by: hsa:80347
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
type: Species

metaM gsn c
is: SBO:0000247
is: CHEBI:16750
type: Species
has only substance units: false
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
is: HMDB00133
initial amount: NaN
constant: false
name: Guanosine
boundary condition: false
is: C00387
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110022#_ab673b80_120a_47f8_8ee5_5ed42d9afcd3
has only substance units: false
initial amount: NaN
name: NOS1
initial concentration: NaN
is: SBO:0000252
is: B4DG68
type: Species
constant: false
boundary condition: true
is encoded by: hsa:4842

http://identifiers.org/biomodels.db/MODEL1310110022#_a551da62_f5d0_4341_bb22_6a61f6e0a747
name: BCAT2
initial concentration: NaN
is: O15382
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:587
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_43b1b086_27d7_4df2_b786_00f7bf34ed46
name: ALDH1B1
boundary condition: true
is: P30837
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:219
initial amount: NaN
type: Species

metaR 5ADTSTSTERONESte
type: Reaction
product: MODEL1310110022#
is described by: ECO:0000000
name: sulfonated testosterone transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
reversible: true
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110022#_8de67af0_9c2c_4b5e_bd55_ca0c6c48f6f3
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: VNN3
type: Species
boundary condition: true
constant: false
is encoded by: hsa:55350

metaR DGK1
reactant: MODEL1310110022#
modifier: MODEL1310110022#
fast: false
kinetic law: MODEL1310110022#
name: deoxyguanylate kinase (dGMP:ATP)
is described by: ECO:0000269
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.8

metaR B3GALTg
fast: false
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.86 Confidence Level: 2 AUTHORS: NOTES:general reaction - no gene association get NJ
name: Beta galactosyltransferase
type: Reaction
reversible: false
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_650be195_7fbe_4a20_a967_ca06d2727d4a
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
is: O94788
constant: false
name: ALDH1A2
has only substance units: false
initial concentration: NaN
is encoded by: hsa:8854

metaM gly c
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB00123
type: Species
notes: FORMULA: C2H5NO2 CHARGE: 0
initial concentration: 1.0
is: C00037
constant: false
is: CHEBI:3339
name: Glycine

metaM ksii core4 deg2 l
is: HMDB00143
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C78H127N6O61S2X CHARGE: -2
is: CHEBI:12936
boundary condition: false
initial amount: NaN
constant: false
type: Species
name: keratan sulfate II (core 4-linked), degradation product 2

metaR r2325
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110022#
fast: false
type: Reaction
product: MODEL1310110022#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110022#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110022#_be13b362_8005_45fe_a58b_ee700a2612ef
has only substance units: false
is: SBO:0000252
is encoded by: hsa:50700
name: RDH8
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is: Q9NYR8
initial amount: NaN

metaR RAI2
is described by: ECO:0000000
product: MODEL1310110022#
name: retinal isomerase (9-cis)
type: Reaction
kinetic law: MODEL1310110022#
reversible: true
fast: false
reactant: MODEL1310110022#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT

metaM pheme m
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
is: C00032
initial amount: NaN
is: CHEBI:17627
initial concentration: 1.0
has only substance units: false
is: HMDB03178
name: Protoheme
constant: false
type: Species
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110022#_c62524ad_5794_4779_be26_f12171621973
is: SBO:0000252
is encoded by: hsa:3417
boundary condition: true
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is: O75874
name: IDH1
initial amount: NaN

metaM prostge1 c
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:57397
name: prostaglandin E1(1-)
is: HMDB01442
has only substance units: false
type: Species
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_d6509d45_d060_4149_9a95_86d6caef40e9
type: Species
is encoded by: hsa:34
name: ACADM
has only substance units: false
is: P11310
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true

metaM CE5236 n
is: http://identifiers.org/pubchem.compound/5041
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
name: O2'-4a-cyclic-tetrahydrobiopterin
is: C01936
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_9f7270c3_a3f9_4a0a_9305_6099882871f5
is: Q53HE2
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:7167
name: TPI1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_4132399d_7d33_482c_83b5_e93c0956656c
type: Species
is: P31350
initial amount: NaN
has only substance units: false
is encoded by: hsa:6241
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: RRM2

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_cbd3f762_b9cc_4f77_a9fa_46a49b1ad7c9
is: Q9BZX2
boundary condition: true
constant: false
is encoded by: hsa:7371
name: UCK2
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaM leuktrA4 r
initial amount: NaN
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
is: SBO:0000247
is: HMDB01337
is: CHEBI:57463
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
name: leukotriene A4(1-)
type: Species

metaM 1pipdn2c x
is: SBO:0000247
boundary condition: false
constant: false
type: Species
is: HMDB01084
name: 1-piperideine-2-carboxylate
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16187
has only substance units: false
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092

metaR ADK3
modifier: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
is: SBO:0000176
name: adentylate kinase (GTP)
is version of: http://identifiers.org/ec-code/2.7.4.3
reversible: true
reactant: MODEL1310110022#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110022#
product: MODEL1310110022#

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

metaR r0634
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.1
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is described by: ECO:0000000
kinetic law: MODEL1310110022#
product: MODEL1310110022#
is: SBO:0000176
fast: false
reactant: MODEL1310110022#
modifier: MODEL1310110022#
reversible: true

metaR EX btn LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biotin exchange
type: Reaction

metaR RAI1
is: SBO:0000176
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
fast: false
is described by: ECO:0000000
reactant: MODEL1310110022#
type: Reaction
reversible: true
product: MODEL1310110022#
name: retinal isomerase (11-cis)

metaM man6p c
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
initial concentration: 1.0
type: Species
is: CHEBI:17369
constant: false
name: D-Mannose 6-phosphate
boundary condition: false
initial amount: NaN
is: HMDB01078
has only substance units: false
is: SBO:0000247

metaM b2coa m
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
constant: false
boundary condition: false
is: CHEBI:57332
initial concentration: 1.0
is: SBO:0000247
name: crotonoyl-CoA(4-)
initial amount: NaN
is: HMDB02009
has only substance units: false
type: Species

metaR r2324
kinetic law: MODEL1310110022#
fast: false
reversible: true
product: MODEL1310110022#
is: SBO:0000185
reactant: MODEL1310110022#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110022#_15b12fce_ee92_41e8_bca4_7d228cb2402f
name: SLC5A10
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: A0PJK1
is encoded by: hsa:125206
initial concentration: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_efbdd72c_7031_48a4_9d2f_e08d30f82729
boundary condition: true
is: SBO:0000252
is: Q15735
is encoded by: hsa:27124
constant: false
type: Species
has only substance units: false
initial amount: NaN
name: INPP5J
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_ead55263_6667_41be_b324_45338445f481
boundary condition: true
has only substance units: false
type: Species
name: GALNTL2
constant: false
initial concentration: NaN
is: Q8N3T1
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:117248

http://identifiers.org/biomodels.db/MODEL1310110022#_d2719d7a_23e8_424c_9eba_ee243f2917d1
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:6520
constant: false
is: P08195
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: SLC3A2

http://identifiers.org/biomodels.db/MODEL1310110022#_e2b3fb08_4f12_4216_9812_5682b07b5f14
constant: false
boundary condition: true
initial concentration: NaN
name: RPIA
initial amount: NaN
type: Species
is: P49247
has only substance units: false
is encoded by: hsa:22934
is: SBO:0000252

metaR EX ksii core4 LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 4-linked) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_dae19083_0735_40f0_b728_436d07157bb7
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: O95168
is encoded by: hsa:4710
name: NDUFB4
boundary condition: true
has only substance units: false

metaM gly e
constant: false
initial concentration: 1.0
notes: FORMULA: C2H5NO2 CHARGE: 0
initial amount: NaN
is: SBO:0000247
is: HMDB00123
boundary condition: false
is: C00037
is: CHEBI:3339
has only substance units: false
type: Species
name: Glycine

metaM met L e
type: Species
boundary condition: false
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
constant: false
is: SBO:0000247
is: HMDB00696
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: L-methionine
is: CHEBI:16643

metaM btn e
type: Species
is: HMDB00030
is: CHEBI:3420
constant: false
name: Biotin
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: C00120
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaR r2327
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
kinetic law: MODEL1310110022#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110022#
reactant: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_df8af8a3_9504_411e_9c50_78ac2a962550
initial amount: NaN
name: SLC38A2
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:54407
type: Species
is: Q96QD8
constant: false
is: SBO:0000252

metaM taur x
is: HMDB00251
has only substance units: false
constant: false
notes: FORMULA: C2H7NO3S CHARGE: 0 INCHI: InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00222 EHMN_ABBREVIATION: C00245
is: SBO:0000247
is: CHEBI:15891
initial concentration: 1.0
name: taurine
boundary condition: false
initial amount: NaN
type: Species

metaR EX idour LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-iduronate
type: Reaction

metaM 1p3h5c m
type: Species
constant: false
has only substance units: false
is: HMDB01369
is: CHEBI:6151
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
boundary condition: false
initial concentration: 1.0
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
is: SBO:0000247
initial amount: NaN

metaM glyald c
boundary condition: false
is: HMDB01051
is: C00577
name: D-Glyceraldehyde
constant: false
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17378
type: Species
has only substance units: false
is: SBO:0000247

metaR MMCDm
reactant: MODEL1310110022#
is described by: ECO:0000212
name: Methylmalonyl-CoA decarboxylase, mitochondrial
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/4.1.1.9
type: Reaction
notes: GENE_ASSOCIATION: (23417.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.1.1.9 Confidence Level: 1 AUTHORS: PMID:12123667,PMID:12955715 NOTES:JLR mitochondrial isoform - NCD
modifier: MODEL1310110022#
fast: false
reversible: false
product: MODEL1310110022#
is: SBO:0000176

metaR 34DHPLACOX
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110022#
name: 3,4-Dihydroxyphenylacetaldehyde:NAD+ oxidoreductase
reactant: MODEL1310110022#
product: MODEL1310110022#
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (218.1) or (222.1) or (220.1) or (221.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110022#_dee992ef_3462_4f61_89e7_aa961b1573bf
has only substance units: false
is: P20933
is encoded by: hsa:175
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
name: AGA
constant: false
initial amount: NaN

metaM 5dhf e
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
is: HMDB06487
has only substance units: false
name: pentaglutamyl folate (DHF)
is: SBO:0000247
constant: false

metaR DM core7 g
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM core7(g)
type: Reaction

metaR r0527
fast: false
type: Reaction
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:
is described by: ECO:0000000
name: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
reversible: true
reactant: MODEL1310110022#
is: SBO:0000176
kinetic law: MODEL1310110022#

metaR r2326
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
kinetic law: MODEL1310110022#
is: SBO:0000185
reversible: true
product: MODEL1310110022#
reactant: MODEL1310110022#
type: Reaction
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

http://identifiers.org/biomodels.db/MODEL1310110022#_ff6664a5_72d6_4b80_a7a9_f3b6bdcea3c0
boundary condition: true
type: Species
is encoded by: hsa:89874
name: SLC25A21
has only substance units: false
is: SBO:0000252
is: G3V4L5
initial amount: NaN
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_b6c5378f_d7e7_4ff3_902e_d1be5af82a16
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
name: HSD3B2
is encoded by: hsa:3284
boundary condition: true
initial amount: NaN
is: P26439
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_69978cc9_0e1a_41cc_8e4f_938c5b878356
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
name: NDUFB6
is encoded by: hsa:4712
is: O95139

metaR RDH3a
is version of: http://identifiers.org/ec-code/1.1.1.300
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.105
fast: false
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110022#
name: retinol dehydrogenase (11-cis,NADPH)
product: MODEL1310110022#
reversible: true
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (112724.1) or (145226.1) or (51109.1) or (57665.1) or (195814.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT

metaM HC02208 e
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
name: prostaglandin-d1
initial amount: NaN
is: CHEBI:27696

http://identifiers.org/biomodels.db/MODEL1310110022#_083b88b7_e958_4a83_a52f_c224428b1787
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:51703
boundary condition: true
constant: false
is: SBO:0000252
is: Q9ULC5
name: ACSL5
has only substance units: false

metaM pect e
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
name: pectins
is: HMDB03402
constant: false
notes: FORMULA: C2535H3509O2535 CHARGE: -1

metaM mmcoa S m
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13+,16+,17+,18-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00495
name: (S)-methylmalonyl-CoA(5-)
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB02310
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:57327
has only substance units: false

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

metaR EX 4abutn LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-ammoniobutanal
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_84e47552_92f0_4034_aef2_7ca8a3981fe3
constant: false
initial amount: NaN
is: P14060
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3283
initial concentration: NaN
name: HSD3B1
type: Species
has only substance units: false

metaR r2329
kinetic law: MODEL1310110022#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_5f79f6ca_8c2a_4c72_a89b_9317c3a0378c
name: ALDH3B1
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
is: P43353
constant: false
is encoded by: hsa:221
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_c396ceb2_6002_476a_9231_b0ca5e976538
initial concentration: NaN
type: Species
is encoded by: hsa:BC005314
has only substance units: false
name: _BC005314_1_x
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN

metaR r1901
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110022#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110022#
reversible: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
fast: false

metaM orn e
type: Species
is: C01602
is: HMDB00214
has only substance units: false
constant: false
is: CHEBI:0
initial concentration: 1.0
notes: FORMULA: C5H13N2O2 CHARGE: 1
initial amount: NaN
boundary condition: false
name: Ornithine
is: SBO:0000247

metaR HSD3A1r
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
modifier: MODEL1310110022#
type: Reaction
reactant: MODEL1310110022#
is: SBO:0000176
product: MODEL1310110022#
is described by: ECO:0000269
kinetic law: MODEL1310110022#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.225
reversible: true

metaR RE3218C
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
reversible: true
type: Reaction
fast: false
product: MODEL1310110022#
is: SBO:0000176
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
name: RE3218
modifier: MODEL1310110022#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.2

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

metaR DHCR71r
product: MODEL1310110022#
fast: false
name: 7-dehydrocholesterol reductase
is version of: http://identifiers.org/ec-code/1.3.1.21
is described by: ECO:0000134
modifier: MODEL1310110022#
type: Reaction
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:9465114 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
reactant: MODEL1310110022#
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110022#_c4f4b8dd_f2bc_4f66_8711_b5982710b368
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3295
initial concentration: NaN
type: Species
initial amount: NaN
name: HSD17B4
constant: false
boundary condition: true
is: E9PB82

http://identifiers.org/biomodels.db/MODEL1310110022#_c3327bfa_e949_4dcc_acb0_187082e0da90
name: RDH14
initial amount: NaN
is: Q9HBH5
boundary condition: true
type: Species
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:57665
initial concentration: NaN

metaM srtn e
constant: false
type: Species
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
name: serotonin(1+)
is: CHEBI:350546
boundary condition: false
is: HMDB00259
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaM HC01231 m
name: N-[(R)-pantothenoyl]-L-cysteinate
is: CHEBI:58480
type: Species
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaM HC02208 c
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
constant: false
initial amount: NaN
is: CHEBI:27696
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
name: prostaglandin-d1

metaM amet c
constant: false
name: S-Adenosyl-L-methionine
is: C00019
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:15414
is: HMDB01185
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR r0630
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
type: Reaction
reversible: true
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.1.3.1
is described by: ECO:0000000
fast: false
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.1.3.2
is: SBO:0000176
kinetic law: MODEL1310110022#

metaR r2328
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
fast: false
product: MODEL1310110022#
type: Reaction
kinetic law: MODEL1310110022#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
reactant: MODEL1310110022#
reversible: true

metaM focytC m
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:16928
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
name: Ferrocytochrome C
initial amount: NaN

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_cbb78726_d435_433a_8799_154ae9ae85ae
name: PANK1
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:53354
type: Species
boundary condition: true

metaR 34DHPLACOX NADP
is described by: ECO:0000269
modifier: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: (222.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110022#
reactant: MODEL1310110022#
reversible: true
is: SBO:0000176
fast: false
name: 3,4-Dihydroxyphenylacetaldehyde:NADP+ oxidoreductase

metaM HC01444 e
type: Species
is: CHEBI:15754
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
has only substance units: false
name: Galactosylglycerol

metaM fuc L c
constant: false
is: CHEBI:18287
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: L-fucose
is: HMDB00174
initial concentration: 1.0
type: Species
has only substance units: false

metaR DRIBt
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110022#
type: Reaction
reversible: true
reactant: MODEL1310110022#
name: deoxyribose transport via diffusion
is: SBO:0000185
product: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_678ed1c9_df4c_467b_b78e_414610e9f73f
has only substance units: false
name: SLC6A10P
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:386757
is: SBO:0000252
type: Species
constant: false
boundary condition: true

metaR RE1448N
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
product: MODEL1310110022#
name: RE1448
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
fast: false

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

metaM orn c
type: Species
is: SBO:0000247
has only substance units: false
is: C01602
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: HMDB00214
initial concentration: 1.0
is: CHEBI:0
constant: false
name: Ornithine
boundary condition: false
initial amount: NaN

metaM srtn c
is: SBO:0000247
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
type: Species
name: serotonin(1+)
constant: false
boundary condition: false
is: CHEBI:350546
has only substance units: false
is: HMDB00259
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110022#_5b71393f_c7bb_42a6_a37c_ec7625ce5eb6
type: Species
has only substance units: false
boundary condition: true
name: _2544_1_c
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2544
constant: false

metaR 34HPPte
product: MODEL1310110022#
name: Transport of 3-(4-hydroxyphenyl)pyruvate
kinetic law: MODEL1310110022#
is described by: ECO:0000134
reactant: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
reversible: true
is: SBO:0000185

metaR r0033
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
fast: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.6.1.5
product: MODEL1310110022#
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
kinetic law: MODEL1310110022#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110022#

metaM nadph c
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: SBO:0000247
is: HMDB00221
initial concentration: 1.0
has only substance units: false
is: CHEBI:57783
initial amount: NaN
boundary condition: false
type: Species
is: C00005
name: Nicotinamide adenine dinucleotide phosphate - reduced
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_9b57298e_1b09_470a_a1f4_378c65d186d6
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2582
is: Q14376
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
name: GALE
boundary condition: true

metaM hdca r
is: SBO:0000247
is: CHEBI:7896
has only substance units: false
constant: false
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
boundary condition: false
initial amount: NaN
is: HMDB00220
is: C00249
initial concentration: 1.0
name: Hexadecanoate (n-C16:0)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_38844ce5_3bb9_4d01_b99c_38272bbd3b9d
name: DLAT:DLD:PDHA1:PDHB:PDHX
is encoded by: hsa:5160
boundary condition: true
has only substance units: false
has part: P08559
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
is: SBO:0000297

metaR RE2659R
is described by: ECO:0000000
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110022#
name: RE2659
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
fast: false
type: Reaction
reactant: MODEL1310110022#
product: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_eb6eb7d4_12a6_434d_bc76_0ab0fa201fd0
is: SBO:0000252
constant: false
is: P14854
has only substance units: false
name: COX6B1
initial amount: NaN
type: Species
is encoded by: hsa:1340
boundary condition: true
initial concentration: NaN

metaR PROSTGE1t
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
name: prostaglandin transport via bicarbonate countertransport
modifier: MODEL1310110022#
fast: false
is: SBO:0000185
product: MODEL1310110022#
reversible: true
reactant: MODEL1310110022#
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110022#_8e387cf2_8ff2_479b_a468_5683a729cf15
has only substance units: false
type: Species
constant: false
is: Q96NR8
name: RDH12
is encoded by: hsa:145226
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_06d715d8_c1b4_4815_ba11_aad96c298c3a
initial amount: NaN
boundary condition: true
name: _AV713053_1_m
is encoded by: hsa:AV713053
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species

metaR CHOLD2m
kinetic law: MODEL1310110022#
name: choline dehydrogenase (FAD acceptor), mitochondrial
is version of: http://identifiers.org/ec-code/1.1.99.1
reactant: MODEL1310110022#
modifier: MODEL1310110022#
reversible: false
is described by: ECO:0000269
fast: false
type: Reaction
product: MODEL1310110022#
is: SBO:0000176
notes: GENE_ASSOCIATION: (55349.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.99.1 Confidence Level: 4 AUTHORS: PMID:15321791 NOTES:

metaR CYTK13
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
name: cytidylate kinase (dCMP,dATP)
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
product: MODEL1310110022#
fast: false
reactant: MODEL1310110022#
is: SBO:0000176
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110022#_f964ecdf_affe_4a84_92cb_0aa8ba5db6a0
has only substance units: false
is: Q9NPH0
name: ACP6
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:51205
is: SBO:0000252
type: Species

metaR FRDPtcr
is described by: ECO:0000134
reactant: MODEL1310110022#
product: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
type: Reaction
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_7d33bb72_a189_48ab_8af8_4d4e01dd86a8
initial concentration: NaN
is: O95861
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
name: BPNT1
has only substance units: false
is encoded by: hsa:10380

metaM btn m
is: CHEBI:57586
initial concentration: 1.0
type: Species
is: HMDB00030
constant: false
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: biotinate
boundary condition: false

metaM udpacgal l
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
type: Species
is: HMDB00304
has only substance units: false
constant: false
is: CHEBI:57847
boundary condition: false
initial amount: NaN
name: UDP-N-acetyl-D-galactosamine(2-)

metaM tsul m
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: thiosulfate(2-)
is: CHEBI:16094
boundary condition: false
type: Species
is: HMDB00257
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_1ffe1788_12f5_4fd9_8d16_0d09a670bd9a
type: Species
is: SBO:0000252
name: SLC22A1
has only substance units: false
boundary condition: true
initial concentration: NaN
is: O15245
initial amount: NaN
constant: false
is encoded by: hsa:6580

metaM pheme c
constant: false
type: Species
is: HMDB03178
name: Protoheme
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
initial amount: NaN
is: C00032
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:17627

metaR NOt
reversible: true
type: Reaction
name: NO transport (diffusion)
reactant: MODEL1310110022#
is described by: ECO:0000000
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
is: SBO:0000185
fast: false
product: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_894b0993_af9d_4087_99ef_6b0eaede06aa
is encoded by: hsa:11254
constant: false
is: Q9UN76
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
name: SLC6A14
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_2a793864_8b4c_4c4b_9eb7_8550ce7c7a6a
is: SBO:0000297
type: Species
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:55350
has only substance units: false
initial concentration: NaN
has part: O95498
is encoded by: hsa:8875
name: VNN3:VNN2:VNN1

metaR CYTK12
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
reactant: MODEL1310110022#
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP,dCTP)
is: SBO:0000176
product: MODEL1310110022#
modifier: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_59443310_2402_4f9d_ad97_dc92036bf3a1
constant: false
is encoded by: hsa:6482
initial amount: NaN
boundary condition: true
name: ST3GAL1
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110022#_2abe7395_06c0_47a0_aa70_56b823b8d3de
is: SBO:0000252
constant: false
is encoded by: hsa:4056
initial amount: NaN
type: Species
boundary condition: true
name: LTC4S
is: Q16873
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_fba2fc0a_dd81_43fb_8b38_a3a09e94a65f
is encoded by: hsa:54576
is: SBO:0000252
initial amount: NaN
name: UGT1A8
constant: false
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is: Q5DSZ6

http://identifiers.org/biomodels.db/MODEL1310110022#_717453cc_80d1_41a9_86f9_259fadd61d9c
constant: false
name: _HG2846_HT2983_1_c
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:HG2846-HT2983

metaR H2O2tn
is: SBO:0000185
name: hydrogen peroxide nuclear transport
fast: false
product: MODEL1310110022#
kinetic law: MODEL1310110022#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:it
reversible: true
type: Reaction
reactant: MODEL1310110022#

metaM dolglcp L r
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:15812
has only substance units: false
constant: false
boundary condition: false
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1

metaR ATPtm
modifier: MODEL1310110022#
reversible: false
is: SBO:0000185
reactant: MODEL1310110022#
type: Reaction
is described by: ECO:0000269
name: ADP/ATP transporter, mitochondrial
product: MODEL1310110022#
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (291.1) or (293.1) or (292.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
fast: false

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

metaR GALt4
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
reactant: MODEL1310110022#
reversible: true
product: MODEL1310110022#
kinetic law: MODEL1310110022#
is described by: ECO:0000269
name: galactose transport via sodium symport
modifier: MODEL1310110022#
type: Reaction

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

metaM 13dampp c
initial concentration: 1.0
is: SBO:0000247
name: trimethylenediaminium
is: CHEBI:57484
is: HMDB00002
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
type: Species
notes: FORMULA: C3H12N2 CHARGE: 2 INCHI: InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2/p+2 EHMN_ABBREVIATION: C00986

metaM g1p c
initial concentration: 1.0
is: HMDB01586
is: CHEBI:58601
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
type: Species
is: C00103
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
name: D-Glucose 1-phosphate

http://identifiers.org/biomodels.db/MODEL1310110022#_cf535f53_14ae_48bb_93d8_b419b92dc859
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AI601100
initial concentration: NaN
constant: false
has only substance units: false
name: _AI601100_1_m
type: Species
boundary condition: true

metaR CYTK11
reactant: MODEL1310110022#
modifier: MODEL1310110022#
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110022#
name: cytidylate kinase (dCMP,dGTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
reversible: true
product: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR r1630
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
product: MODEL1310110022#
fast: false
is: SBO:0000185
type: Reaction

metaR GLYBt4 2 r
kinetic law: MODEL1310110022#
name: Betaine transport (sodium symport) (2:1)
is: SBO:0000185
modifier: MODEL1310110022#
type: Reaction
fast: false
reversible: true
product: MODEL1310110022#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6539.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reactant: MODEL1310110022#

metaR GLNyLATthc
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Glutamine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_808d0216_5031_4ecc_a8ed_a5e7adb8f775
constant: false
is encoded by: hsa:240
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is: P09917
name: ALOX5
is: SBO:0000252

metaR EX progly LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for prolyl-glycine
type: Reaction

metaR CYTK10
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP,dGTP)
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
product: MODEL1310110022#
fast: false
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
is described by: ECO:0000269
reactant: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_3a7240bc_2586_4fca_ad21_3044e3d56583
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10327
constant: false
name: AKR1A1
has only substance units: false
is: P14550
type: Species

metaR FOLR2
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
product: MODEL1310110022#
modifier: MODEL1310110022#
reversible: false
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.3
type: Reaction
is described by: ECO:0000254
name: folate reductase

metaR r1418
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
reversible: true
fast: false
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
type: Reaction
product: MODEL1310110022#
is described by: ECO:0000000

metaR UGALNACtg
reversible: true
modifier: MODEL1310110022#
name: UDP-GalNAc Golgi transport via CMP antiport
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
kinetic law: MODEL1310110022#
fast: false
reactant: MODEL1310110022#
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110022#
type: Reaction

metaR r1493
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:15845416 NOTES:
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000185
reversible: false
name: Utilized transport

metaM ppcoa x
name: Propanoyl-CoA
initial concentration: 1.0
is: SBO:0000247
is: HMDB01275
constant: false
initial amount: NaN
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
type: Species
is: C00100
is: CHEBI:57392
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_ac6b44da_aba4_438d_b4e4_2dffe4298a28
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: SGSH
boundary condition: true
is encoded by: hsa:6448
is: P51688

http://identifiers.org/biomodels.db/MODEL1310110022#_3de11f8a_3d79_4fcd_a40a_f2ec53db8ac0
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:728441
initial amount: NaN
has only substance units: false
name: GGT2

metaR LTC4Sr
type: Reaction
reversible: false
modifier: MODEL1310110022#
fast: false
name: Leukotriene C4 synthase
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (4056.1) or (4259.1) or (4056.2) or (4258.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 4.4.1.20 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:previous EC 2.5.1.37 EC: 4.4.1.20 NJ
is version of: http://identifiers.org/ec-code/4.4.1.20
is version of: http://identifiers.org/ec-code/2.5.1.18
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
product: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_570d399e_6c40_47bd_9b8f_e0de691be806
type: Species
is: P07195
initial concentration: NaN
name: LDHB
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3945

http://identifiers.org/biomodels.db/MODEL1310110022#_56c79d47_6197_4233_ae36_780fe573ae61
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:374291
name: NDUFS7
boundary condition: true
type: Species
has only substance units: false
is: O75251
is: SBO:0000252

metaM apoC m
initial concentration: 1.0
is: HMDB00182
is: SBO:0000247
name: Apocarboxlase (no lys residue)
constant: false
type: Species
has only substance units: false
is: CHEBI:32551
boundary condition: false
notes: FORMULA: XH CHARGE: 0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_7b3e9d11_2e5f_4bf5_9b1f_bb2705117eb7
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:63917
is: B3KWF4
name: GALNT11
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN

metaM ala L m
type: Species
is: HMDB00161
boundary condition: false
name: L-alanine
is: SBO:0000247
is: CHEBI:16977
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0

metaR r0317
fast: false
is described by: ECO:0000000
modifier: MODEL1310110022#
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.4.4.2
is version of: http://identifiers.org/ec-code/1.8.1.4
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.2.10
reactant: MODEL1310110022#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110022#
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:

metaM 42A3HP24DB c
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/7956
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
initial concentration: 1.0
has only substance units: false
is: HMDB04083
is: C05645
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H8NO5 CHARGE: -1 INCHI: InChI=1/C10H9NO5/c11-9-5(2-1-3-6(9)12)7(13)4-8(14)10(15)16/h1-3,12H,4,11H2,(H,15,16) HEPATONET_1.0_ABBREVIATION: HC01547 EHMN_ABBREVIATION: C05645

metaR r2321
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110022#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110022#
reactant: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_a7d5b5d3_d18f_4ac2_b17f_9acf83a76b59
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
is: Q9Y6K8
name: AK5
constant: false
boundary condition: true
is encoded by: hsa:26289
initial concentration: NaN

metaM met L c
is: HMDB00696
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:16643
name: L-methionine
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_daa36b74_92c2_4e46_890b_f1fe2ffe5e88
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
is: Q8IUC8
name: GALNT13
is encoded by: hsa:114805
initial amount: NaN

metaM 3hmp m
constant: false
is: CHEBI:11805
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
is: HMDB00023
has only substance units: false
boundary condition: false
name: 3-hydroxy-2-methylpropanoate

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

metaR GGH 10FTHF7GLUe
modifier: MODEL1310110022#
reversible: false
type: Reaction
fast: false
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
product: MODEL1310110022#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.19.9
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
name: Gamma-glutamyl hydrolase (10FTHF7GLU), extracellular

http://identifiers.org/biomodels.db/MODEL1310110022#_ec9d3720_ed3e_4445_97f1_35d5365a619c
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:8560
has only substance units: false
boundary condition: true
is: O15121
is: SBO:0000252
type: Species
constant: false
name: DEGS1

metaR TDCHOLAte
reactant: MODEL1310110022#
type: Reaction
fast: false
name: bile acid intracellular transport
product: MODEL1310110022#
kinetic law: MODEL1310110022#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ

metaM gchola e
initial amount: NaN
type: Species
boundary condition: false
is: HMDB00138
name: glycocholate
is: SBO:0000247
notes: FORMULA: C26H43NO6 CHARGE: 0
constant: false
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110022#_da9c5c45_ac45_44b3_8769_fd8c6439580b
has only substance units: false
initial amount: NaN
is encoded by: hsa:5337
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is: Q59EA4
name: PLD1

metaM nadph m
is: HMDB00221
boundary condition: false
is: C00005
is: SBO:0000247
type: Species
has only substance units: false
name: Nicotinamide adenine dinucleotide phosphate - reduced
constant: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57783

http://identifiers.org/biomodels.db/MODEL1310110022#_48754429_c07a_4ede_ab98_75ed903e7225
constant: false
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: Q8TCD5
name: NT5C
is encoded by: hsa:30833

metaM hs deg24 l
type: Species
is: CHEBI:15748
is: SBO:0000247
boundary condition: false
notes: FORMULA: C31H50NO26 CHARGE: -1
initial concentration: 1.0
initial amount: NaN
name: GlcNAc-GlcA-(Gal)2-Xyl
constant: false
is: HMDB00127
has only substance units: false

metaM dgsn c
is: HMDB00085
name: Deoxyguanosine
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
constant: false
is: SBO:0000247
is: C00330
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:17172

metaR r2320
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110022#
is: SBO:0000185
product: MODEL1310110022#
reactant: MODEL1310110022#
fast: false
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR GLYCTDle
is described by: ECO:0000134
product: MODEL1310110022#
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
name: difussion of glycerol accross the brush border membrane
fast: false

http://identifiers.org/biomodels.db/MODEL1310110022#_0f929784_46c7_44be_94ea_0a6ca0a31a0a
boundary condition: true
has only substance units: false
name: BCAT1
initial concentration: NaN
initial amount: NaN
is: P54687
is encoded by: hsa:586
constant: false
type: Species
is: SBO:0000252

metaR SQLSr
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.5.1.21
fast: false
type: Reaction
modifier: MODEL1310110022#
reversible: false
reactant: MODEL1310110022#
product: MODEL1310110022#
is: SBO:0000176
kinetic law: MODEL1310110022#
name: Squalene synthase
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ

metaM udpacgal g
type: Species
name: UDP-N-acetyl-D-galactosamine(2-)
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:57847
is: HMDB00304
is: SBO:0000247
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
initial amount: NaN

metaM hdca l
initial concentration: 1.0
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
name: palmitate
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:7896
is: HMDB00220

http://identifiers.org/biomodels.db/MODEL1310110022#_22d5a91e_ac51_4d23_a5fd_c22bac4dfbeb
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:55577
constant: false
is: Q9UJ70
type: Species
initial amount: NaN
initial concentration: NaN
name: NAGK

metaR O2Stx
name: superoxide anion transport via diffusion (peroxisome)
type: Reaction
reversible: true
kinetic law: MODEL1310110022#
is: SBO:0000185
fast: false
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110022#

metaM dhor S c
type: Species
is: SBO:0000247
name: (S)-dihydroorotate
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB03349
is: CHEBI:30864
constant: false
notes: FORMULA: C5H5N2O4 CHARGE: -1 INCHI: InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00285
initial amount: NaN

metaR GK1
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
kinetic law: MODEL1310110022#
name: guanylate kinase (GMP:ATP)
product: MODEL1310110022#
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.7.4.8
reactant: MODEL1310110022#
fast: false
type: Reaction

metaM HC01409 m
boundary condition: false
is: CHEBI:27540
initial amount: NaN
name: Hexanoyl-CoA
is: SBO:0000247
notes: FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h14-16,20-22,26,37-38H,4-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05270
type: Species
initial concentration: 1.0
has only substance units: false
constant: false

metaM dha e
boundary condition: false
is: CHEBI:16016
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
initial amount: NaN
is: HMDB01882
is: SBO:0000247
name: glycerone

metaM ksii core2 deg8 l
has only substance units: false
is: HMDB00143
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
name: keratan sulfate II (core 2-linked), degradation product 8
is: CHEBI:12936
constant: false
initial amount: NaN
notes: FORMULA: C36H60N3O25X CHARGE: 0

metaR GRTTx
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
type: Reaction
reversible: false
fast: false
modifier: MODEL1310110022#
is: SBO:0000176
name: geranyltranstransferase
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.5.1.1
reactant: MODEL1310110022#
product: MODEL1310110022#

metaR ORNt3m
product: MODEL1310110022#
reactant: MODEL1310110022#
modifier: MODEL1310110022#
name: ornithine mitochondrial transport via proton antiport
kinetic law: MODEL1310110022#
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
type: Reaction
reversible: true
fast: false

metaR r0522
is: SBO:0000176
reversible: false
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
fast: false
type: Reaction
reactant: MODEL1310110022#
product: MODEL1310110022#
is described by: ECO:0000000
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
modifier: MODEL1310110022#

metaR EX 4nph LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenol exchange
type: Reaction

metaM core7 g
is: C04383
constant: false
initial amount: NaN
has only substance units: false
name: Core 7
notes: FORMULA: C16H27N2O10X CHARGE: 0
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110022#_ff5a8147_1894_47a9_8959_de42b18789b3
has only substance units: false
is encoded by: hsa:4125
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
name: MAN2B1
is: O00754
initial concentration: NaN
boundary condition: true

metaR RE1836X
type: Reaction
product: MODEL1310110022#
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000176
modifier: MODEL1310110022#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.176
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.154 Confidence Level: 0 AUTHORS: PMID:10706581 NOTES:
name: RE1836
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110022#_778b49b2_34a4_44c9_97ce_20dad0ee77cb
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2517
name: FUCA1
initial amount: NaN
boundary condition: true
type: Species
is: P04066
constant: false

metaR IPDDIx
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/5.3.3.2
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110022#
product: MODEL1310110022#
is: SBO:0000176
name: isopentenyl-diphosphate D-isomerase
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (3422.1) or (91734.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ

metaR NACHEX22ly
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110022#
type: Reaction
reactant: MODEL1310110022#
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110022#
is described by: ECO:0000000
product: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reversible: false
is: SBO:0000176

metaR r2323
product: MODEL1310110022#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
fast: false

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

metaM fuc L l
has only substance units: false
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
initial amount: NaN
is: CHEBI:18287
type: Species
is: SBO:0000247
name: L-fucose
boundary condition: false
constant: false
is: HMDB00174
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110022#_464ad416_a06c_4897_9800_5cff8430c6ff
boundary condition: true
initial amount: NaN
type: Species
constant: false
is: Q99519
is encoded by: hsa:4758
has only substance units: false
name: NEU1
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_0a2e639a_eb8f_4717_85af_0cca0d4863c1
is: SBO:0000252
type: Species
boundary condition: true
constant: false
is: P07327
has only substance units: false
name: ADH1A
initial concentration: NaN
is encoded by: hsa:124
initial amount: NaN

metaR LEUKTRE4t
type: Reaction
reactant: MODEL1310110022#
product: MODEL1310110022#
reversible: true
kinetic law: MODEL1310110022#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
name: leukotriene E4 transport
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110022#_518af855_7290_4d24_9118_005ead11f739
is: Q9NQ66
is encoded by: hsa:23236
initial concentration: NaN
has only substance units: false
name: PLCB1
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
type: Species

metaM gchola c
is: CHEBI:58235
boundary condition: false
name: glycocholate
type: Species
initial amount: NaN
is: HMDB00138
has only substance units: false
is: SBO:0000247
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
initial concentration: 1.0
constant: false

metaR EX gchola LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycocholate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_74f80d31_1a84_4213_a6e5_c360c5b166ec
is: Q16822
name: PCK2
is encoded by: hsa:5106
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
constant: false

metaR ECOAH9m
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110022#
reversible: true
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
modifier: MODEL1310110022#
is: SBO:0000176
is described by: ECO:0000304
reactant: MODEL1310110022#
fast: false

metaR UPPDC1
is version of: http://identifiers.org/ec-code/4.1.1.37
modifier: MODEL1310110022#
type: Reaction
reactant: MODEL1310110022#
name: uroporphyrinogen decarboxylase (uroporphyrinogen III)
kinetic law: MODEL1310110022#
is described by: ECO:0000269
fast: false
product: MODEL1310110022#
is: SBO:0000176
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Heme synthesis EC Number: 4.1.1.37 Confidence Level: 4 AUTHORS: PMID:3015909 NOTES:Acts on a number of porphyrinogens, r0606
reversible: false

metaM dgsn e
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB00085
initial amount: NaN
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
is: C00330
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:17172
name: Deoxyguanosine

metaR r0523
is version of: http://identifiers.org/ec-code/1.17.4.1
kinetic law: MODEL1310110022#
type: Reaction
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
reactant: MODEL1310110022#
is: SBO:0000176
product: MODEL1310110022#

metaM dolp L c
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
is: CHEBI:57683
constant: false
name: dolichyl phosphate(2-)
initial amount: NaN
type: Species

metaR CO2ter
is: SBO:0000185
product: MODEL1310110022#
name: CO2 endoplasmic reticular transport via diffusion
kinetic law: MODEL1310110022#
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110022#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

metaR NDP7er
reactant: MODEL1310110022#
product: MODEL1310110022#
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110022#
reversible: false
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
is described by: ECO:0000000

metaR r2322
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
fast: false
product: MODEL1310110022#
reversible: true
is described by: ECO:0000000

metaR ACCOAtn
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110022#
fast: false
reversible: true
kinetic law: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: acetyl-CoA transport, nuclear
reactant: MODEL1310110022#

metaM 13dpg c
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3535
boundary condition: false
is: SBO:0000247
is: CHEBI:57604
has only substance units: false
is: HMDB01270
is: C00236
name: 3-Phospho-D-glyceroyl phosphate
constant: false
type: Species
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
initial amount: NaN

metaR UMPK3n
kinetic law: MODEL1310110022#
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is described by: ECO:0000269
name: UMP kinase (UTP),nuclear
modifier: MODEL1310110022#
fast: false
is: SBO:0000176
reactant: MODEL1310110022#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14

http://identifiers.org/biomodels.db/MODEL1310110022#_9a347926_3de6_4112_b6d8_57b0d0bb5b7a
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
is: Q9NUB1
name: ACSS1
has only substance units: false
initial concentration: NaN
is encoded by: hsa:84532

metaR ITCOALm
fast: false
is: SBO:0000176
reactant: MODEL1310110022#
is described by: ECO:0000212
is version of: http://identifiers.org/ec-code/6.2.1.5
is version of: http://identifiers.org/ec-code/6.2.1.4
product: MODEL1310110022#
type: Reaction
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
reversible: true
modifier: MODEL1310110022#
name: Itaconate--CoA ligase (ADP-forming), mitochondrial

metaR GLYBtm
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:8443213 NOTES:MM
fast: false
name: Glycine betaine transport via diffusion (mitochondria to cytosol)
reactant: MODEL1310110022#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110022#
reversible: true
is described by: ECO:0000000

metaM o2s e
is: CHEBI:18421
constant: false
initial concentration: 1.0
is: HMDB02168
name: superoxide
type: Species
boundary condition: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaM udpglcur c
is: C00167
is: HMDB00935
name: UDP-D-glucuronate
is: CHEBI:58052
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
constant: false
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110022#_33bbe922_a8a7_4ac2_8c7a_d267ab5e63f6
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
name: FOLR1
initial concentration: NaN
is encoded by: hsa:2348
constant: false
initial amount: NaN

metaR SO4CLtex2
reactant: MODEL1310110022#
reversible: false
fast: false
modifier: MODEL1310110022#
is: SBO:0000185
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
type: Reaction
name: sulfate transport via chloride countertransport (2:1)
product: MODEL1310110022#
is described by: ECO:0000304
kinetic law: MODEL1310110022#

metaM Rtotal e
has only substance units: false
initial amount: NaN
is: HMDB00283
type: Species
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: CO2FULLR CHARGE: -1
name: R total
is: CHEBI:16988

http://identifiers.org/biomodels.db/MODEL1310110022#_786e8e6c_c146_48b9_bfa5_37455788a953
type: Species
initial amount: NaN
is: P09972
boundary condition: true
name: ALDOC
is encoded by: hsa:230
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN

metaM succoa m
name: Succinyl-CoA
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
is: CHEBI:57292
is: HMDB01022
type: Species
constant: false
boundary condition: false
is: SBO:0000247

metaM acnam l
has only substance units: false
is: HMDB00230
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
name: N-acetylneuraminate
initial amount: NaN
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
is: SBO:0000247
is: CHEBI:35418

metaR GLCNACASE1ly
name: alpha-N-acetylglucosaminidase, lysosomal
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
reactant: MODEL1310110022#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.50
type: Reaction
fast: false
modifier: MODEL1310110022#
product: MODEL1310110022#
reversible: false
kinetic law: MODEL1310110022#
is: SBO:0000176

metaR LSTO1r
is described by: ECO:0000269
reactant: MODEL1310110022#
product: MODEL1310110022#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.14.21.6
is: SBO:0000176
kinetic law: MODEL1310110022#
name: Lathosterol oxidase
fast: false
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ

metaM tchola e
notes: FORMULA: C26H45NO7S CHARGE: 0
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
name: taurocholic acid
boundary condition: false
is: HMDB00036

metaM mi145p c
is: HMDB01498
boundary condition: false
constant: false
name: 1D-myo-inositol 1,4,5-trisphosphate(6-)
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:203600
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1 EHMN_ABBREVIATION: C01245

http://identifiers.org/biomodels.db/MODEL1310110022#_950050db_fd19_4e5d_ab0e_6a87d6529195
type: Species
has only substance units: false
is: SBO:0000252
name: SLC25A16
boundary condition: true
initial amount: NaN
constant: false
is: P16260
is encoded by: hsa:8034
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_db8f35c2_4c28_4ad1_84bc_2d942c8122e5
is encoded by: hsa:4514
type: Species
is: SBO:0000252
name: COX3
initial concentration: NaN
initial amount: NaN
is: P00414
has only substance units: false
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_adf132a3_318d_4416_8d15_186728a2373a
is: P09417
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
name: QDPR
is encoded by: hsa:5860
initial amount: NaN

metaM so3 c
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
is: SBO:0000247
is: CHEBI:17137
name: Sulfite
boundary condition: false
type: Species
is: HMDB00240
is: C00094

metaR 4MOPt2im
type: Reaction
product: MODEL1310110022#
is: SBO:0000185
is described by: ECO:0000000
name: 4-methyl-2-oxopentanoate mitochondrial transport via proton symport
fast: false
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
reversible: false
kinetic law: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_a3190dc2_41a2_43a2_a86c_b0c3caa74441
is: P00390
constant: false
name: GSR
is encoded by: hsa:2936
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN

metaM glu L e
has only substance units: false
is: CHEBI:29985
is: SBO:0000247
boundary condition: false
name: L-glutamate(1-)
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB00148
constant: false

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

metaM btamp m
is: CHEBI:3110
has only substance units: false
initial concentration: 1.0
name: Biotinyl-5'-AMP
is: SBO:0000247
type: Species
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
is: HMDB04220
boundary condition: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_659a91bc_8824_4c5d_8266_2f526b924ff8
constant: false
is: Q15392
has only substance units: false
is encoded by: hsa:1718
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
name: DHCR24

metaR NDPK6n
product: MODEL1310110022#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear
type: Reaction
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110022#
is described by: ECO:0000304
reversible: true

metaR SPODMn
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
product: MODEL1310110022#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
is version of: http://identifiers.org/ec-code/1.15.1.1
reversible: false
fast: false
is: SBO:0000176
name: superoxide dismutase, nuclear

metaM his L e
is: HMDB00177
name: L-histidine
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
boundary condition: false
is: CHEBI:15971
has only substance units: false

metaR DINt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
product: MODEL1310110022#
reversible: true
type: Reaction
name: deoxyinosine transport via diffusion
is: SBO:0000185
fast: false
is described by: ECO:0000000

metaR PIter
reactant: MODEL1310110022#
modifier: MODEL1310110022#
type: Reaction
fast: false
name: phosphate transport, endoplasmic reticulum
is described by: ECO:0000212
is: SBO:0000185
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
reversible: true
product: MODEL1310110022#

metaM pap c
constant: false
type: Species
is: HMDB00061
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
initial amount: NaN
has only substance units: false
is: CHEBI:58343
name: adenosine 3',5'-bismonophosphate(4-)
is: SBO:0000247

metaM 5adtststerones c
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: 5alpha-Dihydrotestosterone sulfate
type: Species
is: SBO:0000247
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
boundary condition: false
constant: false
is: HMDB06278

http://identifiers.org/biomodels.db/MODEL1310110022#_7d679cb7_4c23_4881_b554_86cfa97b461d
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5238
type: Species
constant: false
has only substance units: false
name: PGM3
initial amount: NaN
is: SBO:0000252
is: B4DX94

metaM ksi deg6 l
name: keratan sulfate I, degradation product 6
initial concentration: 1.0
is: CHEBI:12936
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C210H336N15O184S11 CHARGE: -11
boundary condition: false
constant: false
is: HMDB00143

metaM Rtotal c
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
name: R total
type: Species
is: CHEBI:16189
is: HMDB01448
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: CO2FULLR CHARGE: -1

metaR G6PPer
kinetic law: MODEL1310110022#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (57818.1) or (2538.1) or (92579.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 3.1.3.9 Confidence Level: 4 AUTHORS: PMID:10078553,PMID:11297555,PMID:12370122,PMID:12965222,PMID:13129915,PMID:15044018,PMID:8211187,PMID:8407995,PMID:9497333 NOTES:NCD
reversible: false
modifier: MODEL1310110022#
is: SBO:0000176
reactant: MODEL1310110022#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.9
name: glucose-6-phosphate phosphatase, edoplasmic reticular
product: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_11a2014d_abc5_4a60_bd10_d341a07260f5
name: ACOT7
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:11332
initial concentration: NaN
boundary condition: true
type: Species
is: O00154
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_0cd19827_9c51_445c_a6c0_c93d27c48415
initial concentration: NaN
type: Species
is encoded by: hsa:AF116616
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
name: _AF116616_1_m
initial amount: NaN

metaR RE3556C
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110022#
reversible: true
type: Reaction
product: MODEL1310110022#
reactant: MODEL1310110022#
name: RE3556

metaR THP2Ctp
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
product: MODEL1310110022#
reactant: MODEL1310110022#
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate transport, peroxisomal
type: Reaction
kinetic law: MODEL1310110022#

metaM for c
is: CHEBI:15740
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: HMDB00142
has only substance units: false
is: C00058
initial concentration: 1.0
constant: false
boundary condition: false
name: Formate

http://identifiers.org/biomodels.db/MODEL1310110022#_8c8487ef_14a6_4986_82ee_c6fe2d1b3420
boundary condition: true
initial amount: NaN
is encoded by: hsa:6519
initial concentration: NaN
has part: P82251
type: Species
has part: Q07837
constant: false
has only substance units: false
is encoded by: hsa:11136
name: SLC7A9:SLC3A1
is: SBO:0000297

metaM h r
initial amount: NaN
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
boundary condition: false
type: Species
name: proton
constant: false
is: CHEBI:24636
is: C00080
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3380

http://identifiers.org/biomodels.db/MODEL1310110022#_6605f474_ff00_4810_9d9f_94326e94f9aa
boundary condition: true
initial amount: NaN
name: IK
is: SBO:0000252
constant: false
is encoded by: hsa:3550
is: Q13123
initial concentration: NaN
has only substance units: false
type: Species

metaM o2s c
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:18421
has only substance units: false
name: superoxide
is: SBO:0000247
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
constant: false
is: HMDB02168

http://identifiers.org/biomodels.db/MODEL1310110022#_23157233_3c0f_461a_a31b_5387811c79f5
boundary condition: true
is encoded by: hsa:2687
initial concentration: NaN
is: P36269
constant: false
name: GGT5
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species

metaR r2310
reactant: MODEL1310110022#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110022#
reversible: true
fast: false

metaM glyc R c
initial amount: NaN
name: D-glycerate
has only substance units: false
is: HMDB00139
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:16659
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
is: SBO:0000247
boundary condition: false

metaR r1010
is described by: ECO:0000000
reversible: true
type: Reaction
kinetic law: MODEL1310110022#
fast: false
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reactant: MODEL1310110022#
is: SBO:0000185
name: Postulated transport reaction

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_933af6c4_c190_467e_9038_71d0dbcbd504
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
is: P23786
has only substance units: false
name: CPT2
constant: false
boundary condition: true
is encoded by: hsa:1376

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

metaR ALCD2yf
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.2
name: alcohol dehydrogenase (ethanol, NADP), forward reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (10327.1) or (10327.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:11003211,PMID:14576493,PMID:19382904,PMID:19382905 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110022#
modifier: MODEL1310110022#
type: Reaction
product: MODEL1310110022#
reversible: false
kinetic law: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_380f8699_edd9_4b6b_9293_fbdb07c7a324
type: Species
constant: false
is encoded by: hsa:8525
has only substance units: false
name: DGKZ
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: G3V0F6

metaM tchola c
constant: false
boundary condition: false
name: taurocholic acid
type: Species
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
is: SBO:0000247
initial concentration: 1.0
is: HMDB00036
initial amount: NaN
is: CHEBI:36257
has only substance units: false

metaR FUCASE2ly
name: alpha-fucosidase, lysosomal
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.2.1.51
reversible: false
kinetic law: MODEL1310110022#
fast: false
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (2517.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:11870229,PMID:1769200,PMID:2803312,PMID:2983333 NOTES:NCD
reactant: MODEL1310110022#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_79e3dc55_5057_4af1_9f33_dee71556bef4
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: HSD3B1
has only substance units: false
is encoded by: hsa:3283
type: Species
initial concentration: NaN
constant: false
is: P14060

metaR EX 34hpp
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_bc5d57b0_fc01_46b2_9acd_01191ecd3e12
type: Species
is encoded by: hsa:6392
has only substance units: false
name: SDHD
constant: false
is: SBO:0000252
is: O14521
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR RE2349C
name: RE2349
is version of: http://identifiers.org/ec-code/2.6.1.64
modifier: MODEL1310110022#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES:IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C
product: MODEL1310110022#
is: SBO:0000176
kinetic law: MODEL1310110022#
fast: false
reactant: MODEL1310110022#
type: Reaction

metaR HS1ly
kinetic law: MODEL1310110022#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.10.1.1
is described by: ECO:0000000
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
modifier: MODEL1310110022#
name: heparan-N-sulfatase, lysosomal
reactant: MODEL1310110022#
reversible: false
is: SBO:0000176

metaR r2311
reversible: true
product: MODEL1310110022#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
fast: false
kinetic law: MODEL1310110022#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
reactant: MODEL1310110022#

metaM glu L c
type: Species
has only substance units: false
boundary condition: false
name: L-glutamate(1-)
constant: false
initial concentration: 1.0
is: CHEBI:29985
is: HMDB00148
is: SBO:0000247
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
initial amount: NaN

metaR r2030
product: MODEL1310110022#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110022#
reactant: MODEL1310110022#
fast: false
kinetic law: MODEL1310110022#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaR DUMPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110022#
fast: false
reactant: MODEL1310110022#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110022#
name: dUMP nuclear transport
reversible: true

metaR CYOR u10m
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.92
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000134
name: ubiquinol-6 cytochrome c reductase, Complex III
type: Reaction
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
reversible: false
modifier: MODEL1310110022#
product: MODEL1310110022#
is: SBO:0000185

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

metaR S6TASE3ly
name: N-acetylglucosamine-6-sulfatase, lysosomal
type: Reaction
kinetic law: MODEL1310110022#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110022#
reversible: true
reactant: MODEL1310110022#
fast: false
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD

metaR O2Stm
fast: false
product: MODEL1310110022#
is described by: ECO:0000000
is: SBO:0000185
name: superoxide anion transport via diffusion (mitochondria)
type: Reaction
reversible: true
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
reactant: MODEL1310110022#

metaR r2202
reactant: MODEL1310110022#
modifier: MODEL1310110022#
reversible: true
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
fast: false
product: MODEL1310110022#
is: SBO:0000185
kinetic law: MODEL1310110022#

metaR IDOAASE2ly
is: SBO:0000176
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
name: alpha-L-iduronidase, lysosomal
type: Reaction
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
fast: false
is described by: ECO:0000000
reversible: false
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.2.1.76

http://identifiers.org/biomodels.db/MODEL1310110022#_29487aa0_f5e0_4c27_b8d6_9e1fcf6e32b8
boundary condition: true
name: _AI640625_1_c
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AI640625

metaM h x
boundary condition: false
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial concentration: 1.0
type: Species
is: C00080
is: http://identifiers.org/pubchem.compound/3380
constant: false
name: proton
initial amount: NaN
is: CHEBI:24636
has only substance units: false
is: SBO:0000247

metaR SERtN1
fast: false
kinetic law: MODEL1310110022#
is described by: ECO:0000269
name: Serine transport (Na, H coupled)
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
modifier: MODEL1310110022#
product: MODEL1310110022#
type: Reaction
reactant: MODEL1310110022#
is: SBO:0000185
reversible: true

metaR EX glyb LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycine betaine exchange
type: Reaction

metaM hom L e
type: Species
boundary condition: false
is: CHEBI:15699
has only substance units: false
is: HMDB00719
constant: false
name: L-homoserine
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaR r1549
fast: false
reactant: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110022#
kinetic law: MODEL1310110022#
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110022#_4ec1eb5a_223f_4f3c_ae52_30bbcb68ad62
name: GPD1
has only substance units: false
boundary condition: true
is: F8W1L5
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:2819
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_5ff7ed53_17d6_4240_b21f_980437e8fa46
is: P52824
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1609
name: DGKQ

metaM nrpphr e
name: Norepinephrine
is: CHEBI:33569
constant: false
is: HMDB00216
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0

metaR GDPFUCtg
modifier: MODEL1310110022#
is described by: ECO:0000269
name: GDPFuc Golgi transport via CMP antiport
product: MODEL1310110022#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (55343.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11326279,PMID:11326280 NOTES:NCD
fast: false
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
is: SBO:0000185

metaR CYTK3n
type: Reaction
product: MODEL1310110022#
reversible: true
reactant: MODEL1310110022#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
name: cytidylate kinase (dCMP,CTP),nuclear
fast: false
is described by: ECO:0000269

metaM pacald c
type: Species
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:16424
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
name: phenylacetaldehyde
is: HMDB06236
is: SBO:0000247
initial concentration: 1.0

metaR TYRt4
modifier: MODEL1310110022#
product: MODEL1310110022#
reversible: false
kinetic law: MODEL1310110022#
name: L-tyrosine transport in via sodium symport
is: SBO:0000185
is described by: ECO:0000304
reactant: MODEL1310110022#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB

metaR r2201
fast: false
product: MODEL1310110022#
modifier: MODEL1310110022#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5

metaR O2Stn
reactant: MODEL1310110022#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
type: Reaction
reversible: true
name: superoxide anion transport via diffusion (nucleus)
fast: false
product: MODEL1310110022#
is: SBO:0000185
kinetic law: MODEL1310110022#

metaR RE1903R
name: RE1903
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:
is: SBO:0000176
product: MODEL1310110022#
type: Reaction
reversible: true
kinetic law: MODEL1310110022#
fast: false
reactant: MODEL1310110022#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110022#_4aa842f0_47a7_4327_bcb4_fa94104fa525
initial concentration: NaN
name: ACSS1
initial amount: NaN
is encoded by: hsa:84532
boundary condition: true
has only substance units: false
is: Q9NUB1
constant: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_f2a810df_0dbc_44c6_b704_9666f450fe1b
boundary condition: true
is: Q86YU0
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:766
constant: false
type: Species
has only substance units: false
initial amount: NaN
name: CA7

metaR H2O2t
reactant: MODEL1310110022#
is: SBO:0000185
kinetic law: MODEL1310110022#
product: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF
fast: false
is described by: ECO:0000000
reversible: true
name: hydrogen peroxide transport via diffusion

metaR ACACt2m
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
kinetic law: MODEL1310110022#
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110022#
reactant: MODEL1310110022#
modifier: MODEL1310110022#
is described by: ECO:0000269
name: Acetoacetate mitochondrial transport via H+ symport

metaR DURIt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110022#
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
name: deoxyuridine transport via diffusion

metaR r1548
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
is: SBO:0000185

metaR RE3520E
is version of: http://identifiers.org/ec-code/1.11.1.9
is described by: ECO:0000000
name: RE3520
product: MODEL1310110022#
is: SBO:0000176
kinetic law: MODEL1310110022#
reversible: true
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
reactant: MODEL1310110022#
fast: false
type: Reaction
modifier: MODEL1310110022#

metaM hs deg22 l
boundary condition: false
name: IdoA-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
notes: FORMULA: C37H56NO35S CHARGE: -3
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:21338
is: HMDB02704
type: Species

metaR TYRTA
name: tyrosine transaminase
is: SBO:0000176
type: Reaction
fast: false
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.6.1.1
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
reversible: true
kinetic law: MODEL1310110022#
is described by: ECO:0000269
product: MODEL1310110022#

metaM HC02210 c
is: CHEBI:34939
constant: false
is: SBO:0000247
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
boundary condition: false
has only substance units: false
name: prostaglandin-d3
type: Species
initial concentration: 1.0
initial amount: NaN

metaR NDPK6m
product: MODEL1310110022#
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
fast: false
modifier: MODEL1310110022#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is described by: ECO:0000254
reversible: true
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
type: Reaction

metaR SERDGLNexR
type: Reaction
fast: false
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
is described by: ECO:0000304
reversible: true
name: D-Serine/Glutamine reversible exchange
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185

metaR r2200
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
is described by: ECO:0000000
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
type: Reaction
product: MODEL1310110022#
kinetic law: MODEL1310110022#
is: SBO:0000185
modifier: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_e256f07a_8e7a_4939_b537_99813b390ba0
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:BE966236
name: _BE966236_1_m
constant: false
initial amount: NaN

metaR NACHEX11ly
product: MODEL1310110022#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110022#
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110022#

metaM hom L c
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:15699
name: L-homoserine
is: HMDB00719
constant: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110022#_c7586f7b_9bee_46c2_bdb4_34c4eee5fa15
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: Q96SL4
name: GPX7
is: SBO:0000252
is encoded by: hsa:2882
constant: false
boundary condition: true

metaR PROSTGI2t
reversible: true
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
is described by: ECO:0000269
name: Prostaglandin I2 transport
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
fast: false
type: Reaction
is: SBO:0000185

metaM didp c
initial concentration: 1.0
is: HMDB03536
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
name: dIDP
is: CHEBI:28823

metaR DNDPt23m
reactant: MODEL1310110022#
is: SBO:0000185
is described by: ECO:0000269
name: dTDP transport via dGTP antiport
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reversible: false
fast: false
type: Reaction
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

metaR TYRt
reversible: true
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
type: Reaction
fast: false
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
is described by: ECO:0000269
product: MODEL1310110022#
name: L-tyrosine transport
modifier: MODEL1310110022#
is: SBO:0000185

metaR 34DHXMANDACOX
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (221.1) or (218.1) or (220.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
kinetic law: MODEL1310110022#
product: MODEL1310110022#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110022#
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase
fast: false

metaR R group phosphotase 1
kinetic law: MODEL1310110022#
reversible: false
reactant: MODEL1310110022#
type: Reaction
product: MODEL1310110022#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
name: R group phosphotase 1
is: SBO:0000176

metaR r1547
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110022#
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000

metaM nrpphr c
has only substance units: false
is: CHEBI:33569
is: SBO:0000247
name: Norepinephrine
type: Species
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
initial concentration: 1.0
initial amount: NaN
is: HMDB00216
constant: false
boundary condition: false

metaM f1a l
notes: FORMULA: C22H37N2O15X CHARGE: 0
is: HMDB02917
has only substance units: false
name: F1alpha
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:17151
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_a6ad7c8a_a0f6_4e75_a0b3_45288d1f7e4a
boundary condition: true
is encoded by: hsa:57194
type: Species
is: O60312
is: SBO:0000252
has only substance units: false
name: ATP10A
initial amount: NaN
constant: false
initial concentration: NaN

metaM HC00900 c
has only substance units: false
initial amount: NaN
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
type: Species
is: SBO:0000247
name: Methylmalonate
boundary condition: false
is: CHEBI:30860
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_18ae11fc_14a8_4c66_aff4_9a0a78678777
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
name: SLC3A2:SLC7A5
is: SBO:0000297
boundary condition: true
has part: Q8IV97
type: Species
is encoded by: hsa:8140

http://identifiers.org/biomodels.db/MODEL1310110022#_dba827a5_a1bc_4008_b3dc_725c2ac2a55c
initial amount: NaN
type: Species
is encoded by: hsa:3030
is: E9KL44
name: HADHA
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252

metaR SUCCtp
reactant: MODEL1310110022#
name: succinate transporter, peroxisome
is described by: ECO:0000000
product: MODEL1310110022#
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110022#_1aa54fc5_0c1e_4066_aac3_1df7c669f87a
is: O14732
is encoded by: hsa:3613
boundary condition: true
type: Species
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
name: IMPA2
is: SBO:0000252

metaM lys L x
name: L-lysinium(1+)
has only substance units: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: CHEBI:32551
initial concentration: 1.0
boundary condition: false
is: HMDB00182
constant: false
initial amount: NaN
is: SBO:0000247
type: Species

metaR GNDer
fast: false
name: phosphogluconate dehydrogenase, endoplasmic reticulum
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.44 Confidence Level: 4 AUTHORS: PMID:2156506 NOTES:SMP Note no proton generation by the the reaction NCD
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
type: Reaction
product: MODEL1310110022#

metaR r1546
fast: false
reactant: MODEL1310110022#
product: MODEL1310110022#
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_458b6899_6767_4cc1_bf99_d9d551a88a09
initial amount: NaN
type: Species
is: Q9H845
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:28976
boundary condition: true
name: ACAD9

metaR LEUKTRB4t
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: leukotriene B4 transport
type: Reaction
is: SBO:0000185
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110022#

metaR ECOAH12m
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
reversible: true
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
is: SBO:0000176
is described by: ECO:0000304
modifier: MODEL1310110022#
product: MODEL1310110022#
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#

metaR r1658
type: Reaction
reversible: true
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110022#
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaM pail45p hs n
name: phosphatidylinositol 4,5-bisphosphate
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
constant: false
is: CHEBI:28910
is: SBO:0000247

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

metaR r2316
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110022#
kinetic law: MODEL1310110022#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110022#

metaM 2dr5p c
is: HMDB01031
constant: false
type: Species
name: 2-deoxy-D-ribose 5-phosphate(2-)
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
is: SBO:0000247
is: CHEBI:57651
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaM docosac r
initial concentration: 1.0
is: C08281
name: Behenic acid
constant: false
type: Species
notes: FORMULA: C22H43O2 CHARGE: -1
is: SBO:0000247
is: HMDB00944
boundary condition: false
has only substance units: false
initial amount: NaN

metaM HC02187 c
name: reverse-triiodthyronine
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:28774
type: Species
constant: false

metaM h l
is: C00080
boundary condition: false
has only substance units: false
name: proton
is: SBO:0000247
type: Species
notes: FORMULA: H CHARGE: 1 INCHI: "
is: http://identifiers.org/pubchem.compound/3380
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:24636

metaR SPODMx
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
type: Reaction
is: SBO:0000176
fast: false
name: superoxide dismutase, peroxisome
kinetic law: MODEL1310110022#
is described by: ECO:0000269
reactant: MODEL1310110022#
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.15.1.1
reversible: false
modifier: MODEL1310110022#

metaR CO2tm
fast: false
name: CO2 transport (diffusion), mitochondrial
kinetic law: MODEL1310110022#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
product: MODEL1310110022#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110022#

metaM glyc R m
name: D-glycerate
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB00139
boundary condition: false
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
is: CHEBI:16659

metaM ficytC m
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:15991
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
name: Ferricytochrome c

http://identifiers.org/biomodels.db/MODEL1310110022#_284ae470_0a76_4087_a5c4_31b0c02af66e
initial concentration: NaN
name: TM7SF2
is: O76062
is encoded by: hsa:7108
constant: false
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN

metaM nadph r
boundary condition: false
has only substance units: false
is: CHEBI:57783
is: SBO:0000247
initial amount: NaN
is: C00005
name: Nicotinamide adenine dinucleotide phosphate - reduced
type: Species
constant: false
initial concentration: 1.0
is: HMDB00221
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005

metaM retfa e
initial amount: NaN
is: HMDB00508
has only substance units: false
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
is: CHEBI:15963
boundary condition: false
name: fatty acid retinol
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false

metaR r1657
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110022#
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
type: Reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
modifier: MODEL1310110022#

metaM arachd e
is: SBO:0000247
has only substance units: false
name: arachidonate
is: CHEBI:32395
boundary condition: false
type: Species
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
initial amount: NaN
is: HMDB01043
initial concentration: 1.0
constant: false

metaR r2317
reversible: true
is: SBO:0000185
reactant: MODEL1310110022#
product: MODEL1310110022#
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110022#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR 3HCO3 NAt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
name: 3HCO3_NAt
fast: false
is described by: ECO:0000134
reactant: MODEL1310110022#
is: SBO:0000185
type: Reaction
product: MODEL1310110022#
kinetic law: MODEL1310110022#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110022#_74d48b94_62d8_43b8_968f_b16aa2d3ce40
constant: false
has only substance units: false
initial amount: NaN
name: SC5DL
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: Q6GTM5
is encoded by: hsa:6309

metaM h m
initial amount: NaN
has only substance units: false
name: proton
constant: false
boundary condition: false
is: CHEBI:24636
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: C00080
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3380
is: SBO:0000247
type: Species

metaM ump r
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: UMP
is: HMDB00288
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
type: Species
is: CHEBI:57865

metaR HOXG
reversible: false
name: Heme oxygenase 1
product: MODEL1310110022#
is described by: ECO:0000134
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3162.1) or (3163.1) SUBSYSTEM: Heme degradation EC Number: 1.14.99.3 Confidence Level: 0 AUTHORS: PMID:16356137 NOTES:TDV (4/28/2004) There are conflicting data on how many moles of NADPH consumed per mole of Biliverdine (Tenhunen 1969, Ryter, 2000). Heme oxygenase is a well known enzyme
fast: false
is version of: http://identifiers.org/ec-code/1.14.99.3
type: Reaction

metaM nac c
notes: FORMULA: C6H4NO2 CHARGE: -1
initial amount: NaN
initial concentration: 1.0
is: C00253
is: HMDB01488
has only substance units: false
is: SBO:0000247
is: CHEBI:0
constant: false
type: Species
name: Nicotinate
boundary condition: false

metaR FALDH
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.1
name: formaldehyde dehydrogenase
product: MODEL1310110022#
fast: false
reactant: MODEL1310110022#
reversible: true
is: SBO:0000176
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#

metaR RE1342C
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
kinetic law: MODEL1310110022#
is: SBO:0000176
name: RE1342
fast: false
reactant: MODEL1310110022#
product: MODEL1310110022#

metaR r0165
modifier: MODEL1310110022#
fast: false
reversible: false
is: SBO:0000176
is described by: ECO:0000000
name: UTP:pyruvate O2-phosphotransferase EC:2.7.1.40
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
type: Reaction

metaR r2398
is: SBO:0000185
reactant: MODEL1310110022#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110022#
fast: false
product: MODEL1310110022#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

metaR URIt5le
fast: false
name: uridine transport in via sodium symport (1:2)
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
modifier: MODEL1310110022#
is: SBO:0000185
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
reversible: false
is described by: ECO:0000134
product: MODEL1310110022#

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_85fb80fe_2b66_4af0_8def_dbfb076ce5d1
is encoded by: hsa:8836
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is: Q92820
name: GGH

metaR r1019
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110022#
reversible: true
product: MODEL1310110022#
fast: false
name: Postulated transport reaction
type: Reaction
reactant: MODEL1310110022#

metaM cmpacna g
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
initial concentration: 1.0
has only substance units: false
is: HMDB01176
type: Species
initial amount: NaN
constant: false
name: CMP-N-acetyl-beta-neuraminate(2-)
is: SBO:0000247
boundary condition: false
is: CHEBI:57812

metaR r1656
is: SBO:0000185
reactant: MODEL1310110022#
product: MODEL1310110022#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110022#
fast: false

metaM glyclt c
type: Species
is: CHEBI:29805
initial amount: NaN
initial concentration: 1.0
name: glycolate
is: HMDB00115
constant: false
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
has only substance units: false
boundary condition: false
is: SBO:0000247

metaM C02470 c
boundary condition: false
is: http://identifiers.org/pubchem.compound/5485
name: Xanthurenic acid
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
type: Species
is: HMDB00881
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
is: C02470

metaR r2318
is described by: ECO:0000000
kinetic law: MODEL1310110022#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
reactant: MODEL1310110022#
product: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true

metaR r0688
fast: false
is described by: ECO:0000000
modifier: MODEL1310110022#
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
type: Reaction
kinetic law: MODEL1310110022#
reversible: true
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110022#
is: SBO:0000176

metaR KSItly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
product: MODEL1310110022#
is: SBO:0000185
reactant: MODEL1310110022#
reversible: false
kinetic law: MODEL1310110022#
type: Reaction
name: keratan sulfate I transport, extracellular to lysosome
is described by: ECO:0000000

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_6383bfc4_6cfa_431f_aeb2_24bc206f5e06
boundary condition: true
name: _AI684467_1_m
is encoded by: hsa:AI684467
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false

metaM Ser Gly Ala X Gly l
initial concentration: 1.0
notes: FORMULA: XH CHARGE: 0
initial amount: NaN
is: CHEBI:17650
constant: false
is: SBO:0000247
is: HMDB00063
boundary condition: false
type: Species
has only substance units: false
name: protein-linked serine residue (glycosaminoglycan attachment site)

http://identifiers.org/biomodels.db/MODEL1310110022#_87fe2e29_0778_4294_97e8_639618bd1549
constant: false
is encoded by: hsa:768
name: CA9
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q16790
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_47c08ff9_da93_4385_8390_5e5fe84ec82e
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q9H008
constant: false
is encoded by: hsa:64077
type: Species
has only substance units: false
is: SBO:0000252
name: LHPP

metaM 6a2ohxnt x
initial amount: NaN
type: Species
is: HMDB12151
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17534
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-4-2-1-3-5(8)6(9)10/h1-4,7H2,(H,9,10) EHMN_ABBREVIATION: C03239
has only substance units: false
constant: false
name: 6-amino-2-oxohexanoic acid
boundary condition: false

metaM pa hs c
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
constant: false
is: CHEBI:57739
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
name: phosphatidate(2-)

metaR r1018
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
fast: false
is: SBO:0000185
product: MODEL1310110022#
kinetic law: MODEL1310110022#
name: Transport reaction
type: Reaction
reactant: MODEL1310110022#
is described by: ECO:0000000

metaR r2142
modifier: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
reversible: true
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110022#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185

metaM arachd c
name: arachidonate
type: Species
has only substance units: false
is: CHEBI:32395
constant: false
is: HMDB01043
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-

metaR r1998
kinetic law: MODEL1310110022#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110022#
reversible: false
is: SBO:0000185
modifier: MODEL1310110022#
fast: false
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaR r1655
product: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110022#
type: Reaction
fast: false
is described by: ECO:0000000
modifier: MODEL1310110022#
is: SBO:0000185
reversible: true
reactant: MODEL1310110022#

metaR r2319
reversible: true
is described by: ECO:0000000
product: MODEL1310110022#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110022#
is: SBO:0000185
kinetic law: MODEL1310110022#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR 3HKYNAKGAT
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.64
reactant: MODEL1310110022#
product: MODEL1310110022#
reversible: false
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
is version of: http://identifiers.org/ec-code/2.6.1.7
fast: false

http://identifiers.org/biomodels.db/MODEL1310110022#_ee6a0f43_789a_404f_ae4b_2a9f944030e2
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:51102
constant: false
initial amount: NaN
is: SBO:0000252
name: MECR
is: Q9BV79
type: Species

metaM btamp c
is: HMDB04220
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:3110
constant: false
boundary condition: false
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
name: Biotinyl-5'-AMP
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_29f1748a_36f2_4492_b185_ff8a5e518215
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:5313
is: SBO:0000252
name: PKLR
constant: false
is: P30613
initial amount: NaN

metaR r1116
reactant: MODEL1310110022#
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:
type: Reaction
kinetic law: MODEL1310110022#
reversible: true
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
product: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_9b32454f_30df_4846_908d_16d32ea3fed7
is encoded by: hsa:6519
is: SBO:0000252
type: Species
constant: false
boundary condition: true
name: SLC3A1
has only substance units: false
initial amount: NaN
is: Q07837
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_07b9b98e_e5b6_4382_85c8_3c81e8ea3e54
name: GMPS
constant: false
boundary condition: true
has only substance units: false
is: P49915
is encoded by: hsa:8833
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252

metaR MALSO3tm
is described by: ECO:0000269
name: Malate:sulfite antiport, mitochondrial
fast: false
product: MODEL1310110022#
modifier: MODEL1310110022#
reactant: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_6e37fbd3_91eb_4b2d_800b_321f298f95a0
is: SBO:0000252
name: SLC25A2
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q9BXI2
type: Species
is encoded by: hsa:83884

metaM ppi c
initial concentration: 1.0
notes: FORMULA: HO7P2 CHARGE: -3
has only substance units: false
boundary condition: false
is: C00013
type: Species
is: SBO:0000247
is: HMDB00250
is: CHEBI:0
constant: false
initial amount: NaN
name: Diphosphate

http://identifiers.org/biomodels.db/MODEL1310110022#_4c03363a_6669_4db9_9bf3_c69349df283a
initial concentration: NaN
is encoded by: hsa:27068
is: SBO:0000252
boundary condition: true
name: PPA2
has only substance units: false
initial amount: NaN
is: Q9H2U2
type: Species
constant: false

metaM HC02210 e
has only substance units: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: prostaglandin-d3
boundary condition: false
constant: false
is: CHEBI:34939

metaR GALASE3ly
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110022#
product: MODEL1310110022#
is described by: ECO:0000000
fast: false
is: SBO:0000176
reactant: MODEL1310110022#
name: beta-galactosidase, lysosomal
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110022#

metaR r1914
fast: false
name: Y+LAT2 Utilized transport
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110022#
kinetic law: MODEL1310110022#
type: Reaction
reversible: false
is: SBO:0000185
modifier: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_8164aa27_a3c7_4575_978a_6812b094d43c
initial amount: NaN
constant: false
name: NDUFA5
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:4698
is: Q16718

metaM dump n
is: SBO:0000247
name: dUMP(2-)
is: HMDB01409
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:246422

metaR r0818
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
name: Transport reaction
fast: false
type: Reaction
reversible: false
is described by: ECO:0000000
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12657464,PMID:14519855,PMID:16194150 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110022#_107ff1d8_8155_4191_8b2a_f180a5309bb0
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: P31937
boundary condition: true
has only substance units: false
type: Species
name: HIBADH
is encoded by: hsa:11112
constant: false

metaR EX idp LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IDP exchange
type: Reaction

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

metaM betald c
name: betaine aldehyde
is: HMDB01252
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:15710

metaM 5aop c
is: CHEBI:17549
type: Species
name: 5-Amino-4-oxopentanoate
constant: false
is: HMDB01149
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
has only substance units: false
is: C00430
initial amount: NaN
is: SBO:0000247

metaR L LACDcm
fast: false
type: Reaction
kinetic law: MODEL1310110022#
name: L-Lactate dehydrogenase, cytosolic/mitochondrial
modifier: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000185
notes: GENE_ASSOCIATION: (124637.1) SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:18831974 NOTES:NCD/TDV. This reaction exists in yeast, but no evidence could be found this exists in humans. However, there may be intramitochondrial lactate dehydrogenase and lactate transport into mitochondria
is described by: ECO:0000000
product: MODEL1310110022#
reversible: false

metaR r2140
is: SBO:0000185
modifier: MODEL1310110022#
reactant: MODEL1310110022#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110022#
product: MODEL1310110022#

metaR PRO1x
name: L-ProlineNAD+ 5-oxidoreductase
type: Reaction
product: MODEL1310110022#
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (58510.1) SUBSYSTEM: Transport, extracellular EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:
fast: false
is described by: ECO:0000134
reversible: false
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.5.99.8
is: SBO:0000176
kinetic law: MODEL1310110022#

metaR r2312
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
type: Reaction
product: MODEL1310110022#
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
fast: false
reversible: true
is: SBO:0000185

metaM 4fumacac c
is: HMDB01268
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1+ HEPATONET_1.0_ABBREVIATION: HC00648 EHMN_ABBREVIATION: C01061
type: Species
is: CHEBI:18034
name: 4-fumarylacetoacetate(2-)
initial amount: NaN

metaM didp n
boundary condition: false
name: dIDP
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28823
is: HMDB03536
has only substance units: false
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344

metaR NACHEX15ly
is: SBO:0000176
product: MODEL1310110022#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
modifier: MODEL1310110022#
reactant: MODEL1310110022#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110022#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_fddc8dc2_386e_42d6_8655_e87b941f9fd2
is: P48728
is: SBO:0000252
boundary condition: true
is encoded by: hsa:275
constant: false
has only substance units: false
initial concentration: NaN
name: AMT
initial amount: NaN
type: Species

metaR r0817
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
reactant: MODEL1310110022#
modifier: MODEL1310110022#
is: SBO:0000185
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.85
is version of: http://identifiers.org/ec-code/2.3.1.41
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110022#
product: MODEL1310110022#

metaR r2313
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110022#
product: MODEL1310110022#
fast: false

metaR r2141
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110022#
fast: false
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
reversible: true

metaR ADEt
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
is described by: ECO:0000269
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD
reactant: MODEL1310110022#
fast: false
product: MODEL1310110022#
name: adenine reversible transport, cytosol

metaM ppp9 m
is: HMDB00241
is: SBO:0000247
type: Species
notes: FORMULA: C34H32N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00905 EHMN_ABBREVIATION: C02191
initial amount: NaN
name: Protoporphyrin
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:36159

metaR r0068
name: Acetyl adenylate:CoA ligase (AMP-forming) Pyruvate metabolism EC:6.2.1.1
type: Reaction
notes: GENE_ASSOCIATION: (134526.1) SUBSYSTEM: Unassigned EC Number: 6.2.1.1 Confidence Level: 0 AUTHORS: PMID:10843999,PMID:14086739,PMID:238571,PMID:2901103 NOTES:
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.1.2.1
reversible: false
fast: false
product: MODEL1310110022#

metaM ppi e
has only substance units: false
constant: false
boundary condition: false
name: Diphosphate
is: C00013
is: CHEBI:33019
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: HMDB00250
is: SBO:0000247

metaR NDPK2n
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reversible: true
type: Reaction
modifier: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
name: nucleoside-diphosphate kinase (ATP:UDP), nuclear

metaR PE HStm
product: MODEL1310110022#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110022#
type: Reaction
name: phosphatidylethanolamine scramblase
reactant: MODEL1310110022#
fast: false

metaM HC02187 e
boundary condition: false
initial concentration: 1.0
name: reverse-triiodthyronine
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
is: CHEBI:28774
is: SBO:0000247
constant: false

metaM cmpacna c
is: HMDB01176
name: CMP-N-acetyl-beta-neuraminate(2-)
constant: false
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:57812
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128

metaM h n
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
constant: false
initial concentration: 1.0
is: CHEBI:24636
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
name: proton

metaR r2314
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
reactant: MODEL1310110022#
product: MODEL1310110022#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR r2393
is described by: ECO:0000000
fast: false
product: MODEL1310110022#
is: SBO:0000185
reversible: true
type: Reaction
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110022#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

http://identifiers.org/biomodels.db/MODEL1310110022#_e1d040c5_5784_4d64_948b_b8bb4bbaff80
initial amount: NaN
name: _D29675_1_e
is encoded by: hsa:D29675
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false

metaM pa hs g
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
is: CHEBI:57739
boundary condition: false
name: phosphatidate(2-)
type: Species
initial concentration: 1.0

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

metaR NICRNS
is: SBO:0000176
reversible: false
reactant: MODEL1310110022#
product: MODEL1310110022#
is described by: ECO:0000000
fast: false
name: NICRNS
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:no gene or enzyme name known (in kegg) but reaction has to take place. IT
kinetic law: MODEL1310110022#
type: Reaction

metaM for e
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
name: formate
is: HMDB00142
is: CHEBI:15740
type: Species
initial concentration: 1.0

metaM dump m
is: CHEBI:246422
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB01409
constant: false
initial amount: NaN
name: dUMP(2-)

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_a595ad28_c091_45b5_8177_679a9552a9be
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4707
is: SBO:0000252
is: O75438
constant: false
name: NDUFB1
type: Species
initial amount: NaN
has only substance units: false

metaM udpglcur r
is: HMDB00935
is: SBO:0000247
is: CHEBI:58052
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
is: C00167
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
name: UDP-D-glucuronate
boundary condition: false

metaR r2315
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110022#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110022#
product: MODEL1310110022#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false

metaM 5adtststerones e
has only substance units: false
is: HMDB06278
boundary condition: false
initial amount: NaN
type: Species
name: 5alpha-Dihydrotestosterone sulfate
initial concentration: 1.0
constant: false
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
is: SBO:0000247

metaR r1659
fast: false
kinetic law: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110022#
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_4b92c66d_1a17_4c5a_92c2_e95fc0553e26
type: Species
name: GPX5
is encoded by: hsa:2880
initial concentration: NaN
is: O75715
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN

metaM his L c
boundary condition: false
name: L-histidine
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:15971
is: HMDB00177
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133

metaM ksii core4 deg1 l
name: keratan sulfate II (core 4-linked), degradation product 1
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB00868
is: CHEBI:57737
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C78H126N6O64S3X CHARGE: -3

metaR r2420
type: Reaction
product: MODEL1310110022#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_9b046965_5f49_4377_b002_3e3294e41da4
constant: false
is encoded by: hsa:AI769281
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
name: _AI769281_1_e
initial amount: NaN
type: Species

metaM nac e
is: SBO:0000247
constant: false
has only substance units: false
is: C00253
is: CHEBI:0
notes: FORMULA: C6H4NO2 CHARGE: -1
initial concentration: 1.0
name: Nicotinate
boundary condition: false
is: HMDB01488
initial amount: NaN
type: Species

metaM leuktrD4 r
name: Leukotriene D4
type: Species
is: CHEBI:28666
is: SBO:0000247
is: HMDB03080
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951

metaR DHCRD1
reversible: false
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000176
name: dihydroceramide desaturase
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
product: MODEL1310110022#
fast: false
is described by: ECO:0000269
type: Reaction

metaM so4 m
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB01448
type: Species
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial concentration: 1.0
boundary condition: false
constant: false
name: sulfate
is: CHEBI:16189

http://identifiers.org/biomodels.db/MODEL1310110022#_d31fce3a_f50e_4260_b691_d6dd2566fc78
initial concentration: NaN
name: CA1
is: SBO:0000252
constant: false
is: P00915
is encoded by: hsa:759
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false

metaM uppg3 c
is: CHEBI:57308
notes: FORMULA: C40H36N4O16 CHARGE: -8 HEPATONET_1.0_ABBREVIATION: HC00643 EHMN_ABBREVIATION: C01051
name: Uroporphyrinogen III
constant: false
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB01086
initial amount: NaN
is: C01051
has only substance units: false
initial concentration: 1.0

metaR r1661
reactant: MODEL1310110022#
product: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
is: SBO:0000185
type: Reaction

metaR GTHRDt
product: MODEL1310110022#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
reactant: MODEL1310110022#
fast: false
is: SBO:0000185
name: Glutathione transport into mitochondria
kinetic law: MODEL1310110022#
type: Reaction

metaM h e
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:24636
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: "
is: http://identifiers.org/pubchem.compound/3380
is: C00080
is: SBO:0000247
name: proton

metaR CYSGLTH
fast: false
name: Glutathione:cystine oxidoreductase
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110022#
kinetic law: MODEL1310110022#
reversible: true
reactant: MODEL1310110022#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_bd374f68_9545_4faf_a121_8f6d25e2eb77
constant: false
is encoded by: hsa:123041
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is: Q8NFF2
initial concentration: NaN
name: SLC24A4
is: SBO:0000252

metaR S6TASE20ly
is version of: http://identifiers.org/ec-code/3.1.6.14
is described by: ECO:0000000
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
reversible: true
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
fast: false
product: MODEL1310110022#
type: Reaction
name: N-acetylglucosamine-6-sulfatase, lysosomal
is: SBO:0000176

metaM chsterol l
name: cholesterol
is: HMDB00067
is: CHEBI:16113
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
initial amount: NaN
constant: false
initial concentration: 1.0

metaR r1662
product: MODEL1310110022#
type: Reaction
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110022#
is described by: ECO:0000000
kinetic law: MODEL1310110022#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110022#_cfb590ab_5d21_4012_a08c_9bc00afaa3a0
is: P15309
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:55
constant: false
name: ACPP

metaR 2OXOADPTm
is described by: ECO:0000269
reactant: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
reversible: true
name: 2-oxoadipate shuttle (cytosol/mitochondria)
kinetic law: MODEL1310110022#
product: MODEL1310110022#
fast: false
is: SBO:0000185
modifier: MODEL1310110022#

metaR r1876
modifier: MODEL1310110022#
reversible: false
type: Reaction
fast: false
name: Y+LAT2 Utilized transport
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_f19d6298_9486_4766_a7fb_ebf20c0d9e9d
constant: false
boundary condition: true
is encoded by: hsa:HG2846-HT2983
type: Species
initial amount: NaN
is: SBO:0000252
name: _HG2846_HT2983_1_m
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_2eac51b1_9e22_4c01_a19e_b66a2145b379
has only substance units: false
is: SBO:0000252
is: Q93099
is encoded by: hsa:3081
constant: false
name: HGD
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN

metaR RE1530C
product: MODEL1310110022#
reversible: true
type: Reaction
fast: false
name: RE1530
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
reactant: MODEL1310110022#

metaR FUCACGALFUCGALACGLCGALGLUSIDEte
fast: false
reversible: true
name: blood group intracellular transport
is described by: ECO:0000000
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_69513f6f_05bd_447a_9ffa_6a435016578c
initial amount: NaN
name: CLYBL
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:171425
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_7aef54f6_f7c6_4bc8_9da5_7cb46d56143d
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:763
boundary condition: true
is: SBO:0000252
is: P35218
constant: false
name: CA5A
initial amount: NaN

metaR MCLOR
is: SBO:0000176
type: Reaction
name: 3-Mercaptolactate:NAD+ oxidoreductase
fast: false
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (92483.1) or (3945.1 and 3939.1) or (55293.1) or (3948.2) or (3948.1) or (3945.1) or (160287.1) or (3939.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:7054184 NOTES:
reversible: true
product: MODEL1310110022#
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.1.1.27
is described by: ECO:0000269

metaM chsterol m
is: CHEBI:16113
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB00067
initial concentration: 1.0
name: cholesterol
constant: false
initial amount: NaN
type: Species

metaM xol7aone m
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:17899
constant: false
name: 7alpha-hydroxycholest-4-en-3-one
boundary condition: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: HMDB01993
initial concentration: 1.0
is: SBO:0000247

metaM core6 g
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
name: Core 6
notes: FORMULA: C16H27N2O10X CHARGE: 0
is: C04383
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_e8ff207d_28de_4787_bbda_1f31b1333546
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1743
is: P36957
initial amount: NaN
name: DLST
boundary condition: true
constant: false
type: Species
has only substance units: false

metaM 2mop m
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
is: CHEBI:57700
type: Species
constant: false
is: HMDB01172
name: 2-methyl-3-oxopropanoate
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

metaM ump g
boundary condition: false
name: UMP(2-)
initial amount: NaN
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:57865
is: HMDB00288

metaM h c
initial concentration: 1.0
is: CHEBI:24636
name: proton
constant: false
is: http://identifiers.org/pubchem.compound/3380
notes: FORMULA: H CHARGE: 1 INCHI: "
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
is: C00080

metaR r0960
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110022#
fast: false
kinetic law: MODEL1310110022#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
product: MODEL1310110022#
reversible: true

metaR CYTK12n
product: MODEL1310110022#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP,dCTP),nuclear
is described by: ECO:0000269
reactant: MODEL1310110022#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_7d4ad61c_bd39_4af9_9c77_8a5e4de2676a
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is: Q8IXW6
name: DPYSL3
is: SBO:0000252
constant: false
is encoded by: hsa:1809
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_08209a07_e161_4a13_93b3_c049c9c3afe2
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is: P50747
has only substance units: false
is encoded by: hsa:3141
is: SBO:0000252
name: HLCS
constant: false

metaR FE2tm
reversible: false
is described by: ECO:0000000
is: SBO:0000185
name: iron (II) transport
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10383398,PMID:12755454 NOTES:TDV Lange H, 1999.
product: MODEL1310110022#

metaR IDOURtly
is: SBO:0000185
reversible: true
product: MODEL1310110022#
kinetic law: MODEL1310110022#
fast: false
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261,PMID:9852127 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 (for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD added IdoA reaction - NCD
name: iduronate transport into lysososme
reactant: MODEL1310110022#
modifier: MODEL1310110022#

metaR r1660
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110022#
is: SBO:0000185
reversible: true
reactant: MODEL1310110022#
is described by: ECO:0000000
modifier: MODEL1310110022#
fast: false
product: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_456ae27f_c596_4257_a44a_c4b485b33a2d
is encoded by: hsa:275
is encoded by: hsa:2653
has only substance units: false
has part: P48728
type: Species
has part: P23434
has part: P23378
initial amount: NaN
constant: false
initial concentration: NaN
name: DLD:GCSH:GLDC:AMT
boundary condition: true
is: SBO:0000297
is encoded by: hsa:2731

metaM so4 l
name: sulfate
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: HMDB01448
type: Species
is: CHEBI:16189
initial concentration: 1.0

metaM pppg9 c
is: C01079
is: CHEBI:57307
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C34H38N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00656 EHMN_ABBREVIATION: C01079
name: Protoporphyrinogen IX
constant: false
has only substance units: false
initial amount: NaN
is: HMDB01097

http://identifiers.org/biomodels.db/MODEL1310110022#_3a8c4ba9_eb3b_45a8_9f22_29d3fd6e6fb6
initial concentration: NaN
is: P23634
is encoded by: hsa:493
is: SBO:0000252
name: ATP2B4
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false

metaM galside hs e
constant: false
is: SBO:0000247
name: D-galactosyl-N-acylsphingosine
type: Species
boundary condition: false
is: CHEBI:12947
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaR BHBtm
kinetic law: MODEL1310110022#
reversible: true
reactant: MODEL1310110022#
product: MODEL1310110022#
is: SBO:0000185
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
type: Reaction
fast: false

metaM ach n
boundary condition: false
is: HMDB00895
name: acetylcholine
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:15355
is: SBO:0000247
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_60f42589_ef6a_4c2f_b4ac_5a67f9485e72
constant: false
boundary condition: true
name: EARS2
is: Q5JPH6
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:124454
type: Species

metaM uacgam g
is: HMDB00290
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:57705
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
initial amount: NaN
name: UDP-N-acetyl-alpha-D-glucosamine(2-)

metaM ppi m
is: CHEBI:33019
is: SBO:0000247
name: Diphosphate
type: Species
is: C00013
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
constant: false
is: HMDB00250
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110022#_b8866efc_0e11_42ca_89ea_efb6b083a773
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
is: B3KT84
is encoded by: hsa:195814
has only substance units: false
boundary condition: true
name: SDR16C5

metaR TTDCAFATPc
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of uptake of Hexadecanoate by the enterocytes by the enterocytes
type: Reaction

metaR GDPtg
is described by: ECO:0000000
type: Reaction
name: GDP intracellular transport
product: MODEL1310110022#
is: SBO:0000185
fast: false
reversible: true
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - likely translocated, unknown transporter/mechanism though NJ
reactant: MODEL1310110022#

metaR r0604
modifier: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000176
kinetic law: MODEL1310110022#
name: (S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
reversible: false
fast: false
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_bac5f1a6_98b9_4581_b7c7_c5edfcfb862c
is: P47895
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:220
name: ALDH1A3

metaR DM 4abut LPAREN n RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: PMID: 16643338 NOTES:GABA in the intestine may aid in differentiation and proliferation of epithelial cells. GABA intake by oral administration has been shown to alleviate stress, worry and anxiety and additionally it can also improve human immunity (PMID: 16971751). However the PAT1 transporter located at the apical side of enterocytes have very low affinity for GABA. I have presumed that this oral GABA is used within intestine (unless administered at high very high pharmacological doses, GABA exit from the enterocytes may be mediated by other specifc transporters).
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for 4-Aminobutanoate(n)
type: Reaction

metaR r1665
name: Y+LAT2 Utilized transport
reactant: MODEL1310110022#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110022#
type: Reaction
fast: false
product: MODEL1310110022#
modifier: MODEL1310110022#
reversible: true

metaR 3SALATAi
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM. activity measured in rat, 3-sulfinoalanine is substrate found in human brain
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
reversible: false
name: 3-sulfino-alanine transaminase (irreversible)
is version of: http://identifiers.org/ec-code/2.6.1.1
is described by: ECO:0000304
modifier: MODEL1310110022#
fast: false
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_3a2c6b68_e3a3_4599_9e03_5fcf3e79eb1a
constant: false
boundary condition: true
is: Q674R7
name: ATG9B
is encoded by: hsa:285973
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR r0160
modifier: MODEL1310110022#
type: Reaction
fast: false
is: SBO:0000176
name: L-Serine:pyruvate aminotransferase Glycine, serine and threonine metabolism EC:2.6.1.51
reactant: MODEL1310110022#
is described by: ECO:0000000
product: MODEL1310110022#
reversible: false
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.51 Confidence Level: 0 AUTHORS: PMID:10347152,PMID:6469715 NOTES:
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.1.3.2

metaM ppi n
constant: false
has only substance units: false
is: HMDB00250
is: CHEBI:33019
is: SBO:0000247
name: diphosphate(3-)
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial concentration: 1.0

metaR RE1254C
kinetic law: MODEL1310110022#
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110022#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
reversible: true
name: RE1254
reactant: MODEL1310110022#

metaM docosac e
initial concentration: 1.0
has only substance units: false
is: C08281
type: Species
constant: false
boundary condition: false
initial amount: NaN
is: HMDB00944
is: SBO:0000247
notes: FORMULA: C22H43O2 CHARGE: -1
name: Behenic acid

http://identifiers.org/biomodels.db/MODEL1310110022#_b409008a_237d_4dff_bc47_cc0821a7c0d5
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
name: STS
is: P08842
is encoded by: hsa:412
initial concentration: NaN
constant: false

metaM ksi deg30 l
is: HMDB00143
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:12936
name: keratan sulfate I, degradation product 30
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C90H147N6O75S3 CHARGE: -3

http://identifiers.org/biomodels.db/MODEL1310110022#_d2f77d8d_0221_45e6_a9a8_9af53762a265
initial concentration: NaN
is: SBO:0000252
is: O14734
is encoded by: hsa:10005
type: Species
has only substance units: false
constant: false
initial amount: NaN
name: ACOT8
boundary condition: true

metaM cholate c
is: HMDB00619
type: Species
is: CHEBI:29747
has only substance units: false
initial concentration: 1.0
name: Cholate
constant: false
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaM 4aphdob c
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58147
is: HMDB00978
initial amount: NaN
type: Species
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
constant: false
has only substance units: false

metaM ump n
has only substance units: false
initial concentration: 1.0
is: CHEBI:57865
initial amount: NaN
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
constant: false
type: Species
is: HMDB00288
boundary condition: false
is: SBO:0000247
name: UMP(2-)

metaM prpp c
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
is: HMDB00280
is: SBO:0000247
is: CHEBI:58017
type: Species
is: C00119
has only substance units: false
initial amount: NaN
name: 5-Phospho-alpha-D-ribose 1-diphosphate
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_a66014be_ae83_4c0c_b2c6_97acf1fbb771
type: Species
name: NME2
constant: false
initial concentration: NaN
is: SBO:0000252
is: P22392
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:4831

metaR CITt4 4
fast: false
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
product: MODEL1310110022#
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
type: Reaction
is: SBO:0000185
name: citrate transport via sodium symport
reactant: MODEL1310110022#
is described by: ECO:0000006
reversible: true

metaR r1666
reactant: MODEL1310110022#
is: SBO:0000185
modifier: MODEL1310110022#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110022#
name: Y+LAT2 Utilized transport
product: MODEL1310110022#
is described by: ECO:0000000
type: Reaction

metaR r0603
is described by: ECO:0000000
kinetic law: MODEL1310110022#
fast: false
product: MODEL1310110022#
type: Reaction
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.3.1.12
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
reactant: MODEL1310110022#

metaR r2308
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110022#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
reversible: true
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_8d464a1c_1f78_4812_9157_a250e3b53678
is: P15531
boundary condition: true
is encoded by: hsa:4830
is: SBO:0000252
name: NME1
has only substance units: false
type: Species
initial amount: NaN
constant: false
initial concentration: NaN

metaM HC02207 c
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
boundary condition: false
name: prostaglandin-c2
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:27555

metaR r0698
is version of: http://identifiers.org/ec-code/3.1.2.27
modifier: MODEL1310110022#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110022#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:12543708,PMID:3746130,PMID:6378901 NOTES:
name: Propanoyl-CoA:acetyl-CoA C-acyltransferase Bile acid biosynthesis EC:2.3.1.16
type: Reaction
product: MODEL1310110022#

metaM 3hbcoa m
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
is: HMDB01166
is: SBO:0000247
type: Species
is: CHEBI:57316
name: (S)-3-hydroxybutanoyl-CoA(4-)
initial concentration: 1.0

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

metaM xol7aone r
initial amount: NaN
boundary condition: false
constant: false
name: 7alpha-hydroxycholest-4-en-3-one
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: CHEBI:17899
has only substance units: false
initial concentration: 1.0
is: HMDB01993
is: SBO:0000247
type: Species

metaM 5aop m
has only substance units: false
constant: false
is: C00430
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
is: HMDB01149
name: 5-Amino-4-oxopentanoate
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17549

http://identifiers.org/biomodels.db/MODEL1310110022#_1906cd23_8c3e_4799_a8fd_f7dc9e62cd4e
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: Q3I5F7
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:641372
name: ACOT6

metaR r0385
is: SBO:0000176
fast: false
kinetic law: MODEL1310110022#
is described by: ECO:0000000
reactant: MODEL1310110022#
product: MODEL1310110022#
reversible: false
name: 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
type: Reaction

metaR MTHFD2m
reactant: MODEL1310110022#
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.9
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
is described by: ECO:0000254
product: MODEL1310110022#
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
fast: false

metaM ser D e
type: Species
initial amount: NaN
name: D-serine
is: CHEBI:16523
is: HMDB03406
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false

metaM hgentis c
initial concentration: 1.0
is: CHEBI:16169
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 HEPATONET_1.0_ABBREVIATION: HC00423 EHMN_ABBREVIATION: C00544
constant: false
name: homogentisate
is: HMDB00130
boundary condition: false
initial amount: NaN

metaM h g
name: proton
initial amount: NaN
is: CHEBI:24636
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: SBO:0000247
type: Species

metaM sphgn c
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB00269
has only substance units: false
is: CHEBI:57817
name: sphinganine(1+)
is: SBO:0000247
initial amount: NaN

metaM pail45p hs c
is: CHEBI:28910
constant: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: phosphatidylinositol 4,5-bisphosphate
has only substance units: false

metaR r0384
name: 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2
fast: false
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
type: Reaction
reactant: MODEL1310110022#
product: MODEL1310110022#
reversible: false
is: SBO:0000176
is described by: ECO:0000000

metaM nad x
is: C00003
boundary condition: false
is: CHEBI:57540
initial concentration: 1.0
is: SBO:0000247
name: Nicotinamide adenine dinucleotide
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/3305
initial amount: NaN
is: HMDB00902
has only substance units: false

metaR r0497
is: SBO:0000176
modifier: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
fast: false
kinetic law: MODEL1310110022#
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/1.2.4.2
type: Reaction
product: MODEL1310110022#

metaM HC01522 c
is: SBO:0000247
name: Gentisate aldehyde
constant: false
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:28508
initial concentration: 1.0
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585

metaM prpp e
is: CHEBI:58017
constant: false
type: Species
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
is: HMDB00280
has only substance units: false
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaM cholate e
is: HMDB00619
has only substance units: false
is: SBO:0000247
name: Cholate
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
is: CHEBI:29747
initial amount: NaN
constant: false

metaR 2HBO
reactant: MODEL1310110022#
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110022#
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (92483.1) or (3948.2) or (55293.1) or (3945.1 and 3939.1) or (3939.1) or (160287.1) or (3945.1) or (3948.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:10108,PMID:21765 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.1.27
fast: false
is: SBO:0000176
name: 2-Hydroxybutyrate:NAD+ oxidoreductase
modifier: MODEL1310110022#
type: Reaction

metaR 3SPYRSP
is: SBO:0000176
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM
is described by: ECO:0000000
type: Reaction
name: 3-sulfinopyruvate hydrolase (spotaneous reaction)
reversible: false
reactant: MODEL1310110022#
fast: false
product: MODEL1310110022#

metaR CYSGLUexR
reactant: MODEL1310110022#
product: MODEL1310110022#
is described by: ECO:0000304
name: L-cysteine/L-glutamine reversible exchanger
is: SBO:0000185
modifier: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110022#
reversible: true

metaM HC02207 e
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:27555
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
name: prostaglandin-c2
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110022#_e4b269bb_de44_454c_be87_39e526db8d59
boundary condition: true
type: Species
is: Q5QPH3
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:55902
name: ACSS2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_9cfc5735_a6f8_49f3_8b48_2b5f12edefa7
is encoded by: hsa:48
type: Species
has only substance units: false
is: SBO:0000252
name: ACO1
boundary condition: true
constant: false
initial amount: NaN
is: P21399
initial concentration: NaN

metaR EX oxa LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Oxalate exchange
type: Reaction

metaR HIStiDF
is described by: ECO:0000269
product: MODEL1310110022#
kinetic law: MODEL1310110022#
type: Reaction
is: SBO:0000185
name: L-histidine transport via diffusion (extracellular to cytosol)
modifier: MODEL1310110022#
reversible: false
notes: GENE_ASSOCIATION: (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754 NOTES:SAB
reactant: MODEL1310110022#
fast: false

metaR r0812
is: SBO:0000185
product: MODEL1310110022#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.41
fast: false
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#

metaR PI4PP
reactant: MODEL1310110022#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2425833 NOTES:NCD
is: SBO:0000176
product: MODEL1310110022#
fast: false
kinetic law: MODEL1310110022#
type: Reaction
name: phosphatidylinositol-4-phosphate 4-phosphatase

metaR r1664
modifier: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110022#
is: SBO:0000185
name: Y+LAT2 Utilized transport
fast: false
product: MODEL1310110022#
is described by: ECO:0000000
type: Reaction

metaR 2AMADPTm
name: L-2-aminoadipate shuttle (cytosol/mitochondria)
fast: false
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reversible: true
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110022#
type: Reaction
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877

metaM fald c
has only substance units: false
initial concentration: 1.0
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
is: HMDB01426
boundary condition: false
initial amount: NaN
is: CHEBI:16842
constant: false
name: formaldehyde
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110022#_e023ed6b_dcea_4841_80dc_c8f806699c92
constant: false
is: SBO:0000252
is: Q9BY49
boundary condition: true
name: PECR
has only substance units: false
is encoded by: hsa:55825
initial concentration: NaN
type: Species
initial amount: NaN

metaM ser L e
type: Species
initial amount: NaN
is: CHEBI:17115
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
constant: false
name: L-serine
is: HMDB00187
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaR r1556
reactant: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110022#
product: MODEL1310110022#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

metaR ABUTD
type: Reaction
is: SBO:0000176
name: Aminobutyraldehyde dehydrogenase
is described by: ECO:0000269
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: (223.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.19 Confidence Level: 4 AUTHORS: PMID:8786138 NOTES:JLR
reversible: false
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110022#

metaM ach c
type: Species
constant: false
name: acetylcholine
has only substance units: false
is: HMDB00895
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
is: CHEBI:15355
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110022#_9d43ff47_f503_4a07_9e49_8a2706fa17f6
is: B3KQH0
is encoded by: hsa:55343
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
name: SLC35C1

metaR GLNtm
type: Reaction
kinetic law: MODEL1310110022#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110022#
product: MODEL1310110022#
is: SBO:0000185
name: L-glutamine transport via electroneutral transporter
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)

metaM ca2 e
initial amount: NaN
type: Species
is: HMDB00464
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
is: CHEBI:29108
name: calcium(2+)

http://identifiers.org/biomodels.db/MODEL1310110022#_976c98f8_d72b_41ce_9116_befc7dfb7412
initial concentration: NaN
name: PLCE1
type: Species
is: SBO:0000252
is: Q9P212
constant: false
is encoded by: hsa:51196
has only substance units: false
boundary condition: true
initial amount: NaN

metaM gdpddman c
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB01346
notes: FORMULA: C16H21N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H23N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,8-11,14-15,23-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00728 EHMN_ABBREVIATION: C01222
constant: false
name: GDP-4-dehydro-6-deoxy-alpha-D-mannose(2-)
is: CHEBI:57964
type: Species
has only substance units: false

metaR GLYt4
fast: false
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:SAB irreversible
product: MODEL1310110022#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110022#
reversible: false
kinetic law: MODEL1310110022#
name: glycine transport via sodium symport
reactant: MODEL1310110022#
is: SBO:0000185

metaM so4 e
constant: false
is: CHEBI:16189
boundary condition: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
has only substance units: false
name: sulfate
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB01448
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110022#_ebf47b21_c097_40de_8022_fb0666cf4776
is encoded by: hsa:10331
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: B3GNT3
has only substance units: false
constant: false
is: Q9Y2A9
boundary condition: true
type: Species

metaM uacgam c
type: Species
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
is: SBO:0000247
is: HMDB00290
is: CHEBI:57705

metaR biomass reaction
product: MODEL1310110022#
kinetic law: MODEL1310110022#
reversible: false
name: biomass_reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
fast: false
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110022#

metaR SO4tl
is: SBO:0000185
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
fast: false
type: Reaction
name: Sulfate transport (lysosome)
kinetic law: MODEL1310110022#
is described by: ECO:0000269
reactant: MODEL1310110022#
reversible: true

metaR r1557
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110022#
reversible: true
product: MODEL1310110022#

metaR S6TASE14ly
modifier: MODEL1310110022#
fast: false
reactant: MODEL1310110022#
type: Reaction
is: SBO:0000176
name: N-acetylglucosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.14
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110022#
product: MODEL1310110022#

metaM ppi r
is: SBO:0000247
name: Diphosphate
is: HMDB00250
is: CHEBI:33019
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: C00013
initial amount: NaN
has only substance units: false
type: Species

ORG:
  orgname: University of Manchester
n:
  given: Neil
  family: Swainston

metaM chsterol c
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB00067
type: Species
has only substance units: false
is: CHEBI:16113
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
is: SBO:0000247
name: cholesterol
constant: false

metaR EX hspg LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heparan sulfate proteoglycan exchange
type: Reaction

metaM ser L c
name: L-serine
boundary condition: false
is: CHEBI:17115
is: HMDB00187
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: SBO:0000247
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_668fa2f0_4cd8_44d3_990d_61473e8c16b2
is encoded by: hsa:AA788780
boundary condition: true
initial concentration: NaN
name: _AA788780_1_c
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_e724bdec_a0bb_4306_a9df_62049cdeb54f
initial amount: NaN
is encoded by: hsa:2762
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
name: GMDS
is: O60547

http://identifiers.org/biomodels.db/MODEL1310110022#_53f25584_e696_49f1_8963_3d248511d682
is encoded by: hsa:6307
initial concentration: NaN
name: MSMO1
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is: A8MYF6
is: SBO:0000252
constant: false

metaM retinol cis 11 c
constant: false
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:16302
initial concentration: 1.0
name: 11-cis-retinol
is: SBO:0000247
is: HMDB06216
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+

metaR r0541
type: Reaction
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.6.1.5
reactant: MODEL1310110022#
product: MODEL1310110022#
kinetic law: MODEL1310110022#
reversible: true
is: SBO:0000176

metaR RE1796M
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
type: Reaction
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.1.1.145
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110022#
modifier: MODEL1310110022#
name: RE1796
is: SBO:0000176

metaM ach e
is: HMDB00895
name: acetylcholine
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:15355
is: SBO:0000247
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
constant: false
type: Species

metaR r1554
is described by: ECO:0000000
reversible: true
type: Reaction
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

metaM L2aadp6sa c
is: SBO:0000247
initial amount: NaN
name: L-allysine
constant: false
type: Species
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
is: HMDB01263
boundary condition: false
is: CHEBI:17917
has only substance units: false
initial concentration: 1.0

metaM sphmyln hs c
has only substance units: false
initial amount: NaN
is: CHEBI:58216
is: SBO:0000247
constant: false
initial concentration: 1.0
name: sphingomyelin betaine
type: Species
boundary condition: false
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007

http://identifiers.org/biomodels.db/MODEL1310110022#_23d4949a_d7c9_4bd9_993d_5de74c91c0da
name: NDUFB8
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:4714
type: Species
initial concentration: NaN
is: O95169
is: SBO:0000252

metaR PRODt2r
is: SBO:0000185
modifier: MODEL1310110022#
product: MODEL1310110022#
fast: false
name: D-proline reversible transport via proton symport
type: Reaction
is described by: ECO:0000304
reversible: true
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#

metaM glu L l
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:29985
name: L-glutamate(1-)
constant: false
is: HMDB00148
has only substance units: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
initial concentration: 1.0
initial amount: NaN

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

metaR r0968
is described by: ECO:0000000
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
fast: false
product: MODEL1310110022#
type: Reaction
reactant: MODEL1310110022#
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110022#

metaM duri c
is: C00526
has only substance units: false
name: Deoxyuridine
is: HMDB00012
constant: false
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: CHEBI:16450
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110022#_0cefac57_0e15_42be_ab6b_d48ada9ab2c5
has only substance units: false
constant: false
name: NT5C3
is encoded by: hsa:51251
is: Q9H0P0
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_ba64b288_0373_4a2c_9157_ad4cc498a688
is: Q14916
is encoded by: hsa:6568
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
name: SLC17A1
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_f7b27832_8e23_47d4_80fb_7118a156a1b6
is: SBO:0000252
is: P12074
initial concentration: NaN
name: COX6A1
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:1337
type: Species
constant: false

metaM so4 c
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
type: Species
is: SBO:0000247
is: HMDB01448
boundary condition: false
initial amount: NaN
is: CHEBI:16189
has only substance units: false
constant: false
initial concentration: 1.0
name: sulfate

metaR DAGK hs
modifier: MODEL1310110022#
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110022#
product: MODEL1310110022#
name: Diacylglycerol phosphate kinase (homo sapiens)
reversible: true
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.7.1.107
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_3f650be9_913e_401d_8079_442c27d70653
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is: P09972
is encoded by: hsa:230
type: Species
boundary condition: true
is: SBO:0000252
name: ALDOC

metaR r0494
fast: false
kinetic law: MODEL1310110022#
is: SBO:0000176
reactant: MODEL1310110022#
product: MODEL1310110022#
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_5b811dff_ac5d_4248_9994_8970f7fd398f
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
type: Species
is: Q86SR1
is encoded by: hsa:55568
name: GALNT10
is: SBO:0000252

metaR r0410
type: Reaction
reversible: true
reactant: MODEL1310110022#
fast: false
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
product: MODEL1310110022#
kinetic law: MODEL1310110022#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110022#_0851a3db_f082_45c1_b4b9_fef11aa079a5
initial amount: NaN
name: _AI926493_1_m
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:AI926493
constant: false
is: SBO:0000252
type: Species

metaR r2419
is: SBO:0000185
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110022#
fast: false
reactant: MODEL1310110022#

metaM chsterol e
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
name: cholesterol
boundary condition: false
is: HMDB00067
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:16113
constant: false
has only substance units: false
initial amount: NaN

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

metaM s7p c
name: Sedoheptulose 7-phosphate
constant: false
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382
has only substance units: false
is: HMDB01068
is: CHEBI:57483
boundary condition: false
initial amount: NaN
is: C05382
type: Species
initial concentration: 1.0
is: SBO:0000247

metaR NADHtru
reactant: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
is: SBO:0000185
kinetic law: MODEL1310110022#
is described by: ECO:0000000
reversible: false
product: MODEL1310110022#
name: NADH transporter, endoplasmic reticulum
type: Reaction

metaM glu L m
name: L-glutamate(1-)
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:29985
initial amount: NaN
is: HMDB00148
is: SBO:0000247
type: Species
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025

metaM aps c
is: CHEBI:58243
is: SBO:0000247
is: HMDB01003
boundary condition: false
type: Species
constant: false
initial amount: NaN
has only substance units: false
name: 5'-adenylyl sulfate(2-)
notes: FORMULA: C10H12N5O10PS CHARGE: -2 INCHI: InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00204 EHMN_ABBREVIATION: C00224
initial concentration: 1.0

metaM docosac c
name: Behenic acid
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
is: C08281
is: HMDB00944
boundary condition: false
notes: FORMULA: C22H43O2 CHARGE: -1
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_5b45ebb1_90db_49f5_9d07_772b2fa01164
is encoded by: hsa:LOC727762
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
name: _LOC727762_1_m
has only substance units: false
initial amount: NaN
type: Species

metaM CE5236 c
has only substance units: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5041
is: C01936
name: O2'-4a-cyclic-tetrahydrobiopterin
constant: false
type: Species

metaM sphings c
initial amount: NaN
is: HMDB00252
is: CHEBI:57756
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
name: sphingosine(1+)
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
type: Species
boundary condition: false

metaR EX Lcystin LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Cystine exchange
type: Reaction

metaM gmp c
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58115
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
constant: false
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB01397
is: C00144
name: GMP
boundary condition: false

metaM glu L r
is: SBO:0000247
type: Species
is: CHEBI:29985
initial concentration: 1.0
constant: false
is: HMDB00148
name: L-glutamate(1-)
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110022#_1cb421e0_1052_4d9b_9100_89e53388eafe
name: _AI694761_1_c
is encoded by: hsa:AI694761
initial concentration: NaN
boundary condition: true
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR S6TASE18ly
product: MODEL1310110022#
kinetic law: MODEL1310110022#
type: Reaction
reactant: MODEL1310110022#
modifier: MODEL1310110022#
name: N-acetylglucosamine-6-sulfatase, lysosomal
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.14
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176

metaM 4hpro LT m
name: trans-4-hydroxy-L-proline
is: CHEBI:18095
is: HMDB00725
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
type: Species
has only substance units: false

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

metaM co e
is: HMDB01361
name: carbon monoxide
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
is: CHEBI:17245
constant: false
initial concentration: 1.0
type: Species

metaR RE1233C
modifier: MODEL1310110022#
fast: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110022#
type: Reaction
name: RE1233
reversible: true
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.6.1.64
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
kinetic law: MODEL1310110022#

metaR r1552
is described by: ECO:0000000
product: MODEL1310110022#
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110022#
reversible: true
kinetic law: MODEL1310110022#
fast: false

metaM arachd r
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
is: CHEBI:32395
name: arachidonate
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB01043
boundary condition: false
constant: false

metaR URIDK2m
reversible: true
kinetic law: MODEL1310110022#
type: Reaction
name: uridylate kinase (dUMP), mitochondrial
reactant: MODEL1310110022#
is described by: ECO:0000134
product: MODEL1310110022#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:IT

metaR FUCACGALFUCGALACGLCGALGLUSIDEtg
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
is described by: ECO:0000000
name: blood group intracellular transport
fast: false
product: MODEL1310110022#
type: Reaction
reversible: true
reactant: MODEL1310110022#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110022#_b40f3677_3bff_4ca9_8efe_914124f2b42b
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:57282
boundary condition: true
constant: false
is: B7Z1R0
initial amount: NaN
name: SLC4A10

http://identifiers.org/biomodels.db/MODEL1310110022#_2ed085d4_6bb4_46e8_97f0_a9de15094756
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is: Q14032
initial amount: NaN
type: Species
name: BAAT
is encoded by: hsa:570

metaR DHFtm
is described by: ECO:0000000
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
kinetic law: MODEL1310110022#
fast: false
type: Reaction
product: MODEL1310110022#
is: SBO:0000185
reversible: true
name: dihydrofolate reversible mitochondrial transport

metaM 10fthf5glu m
initial concentration: 1.0
boundary condition: false
type: Species
name: 10-formyltetrahydrofolate-[Glu](5)
notes: FORMULA: C40H45N11O19 CHARGE: -6
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false

metaM duri e
initial concentration: 1.0
constant: false
boundary condition: false
name: Deoxyuridine
type: Species
is: HMDB00012
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
has only substance units: false
is: CHEBI:16450
initial amount: NaN
is: SBO:0000247
is: C00526

metaR ADCim
kinetic law: MODEL1310110022#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 4.1.1.4 Confidence Level: 2 AUTHORS: NOTES:TDV (Voet & Voet pg 581) Non-enzymatic decarboxylation; spontaneous reaction added "m" suffix - NCD
product: MODEL1310110022#
type: Reaction
name: Acetoacetate decarboxylation (irreversible), mitochondrial
reactant: MODEL1310110022#
is described by: ECO:0000000
reversible: false

metaR KSII CORE2tly
is described by: ECO:0000000
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
reversible: false
is: SBO:0000185
product: MODEL1310110022#
name: keratan sulfate II (core 2) transport, extracellular to lysosome
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110022#_a4b0fa3e_61b7_40be_8fde_b9946906e016
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4719
is: SBO:0000252
is: P28331
boundary condition: true
type: Species
has only substance units: false
constant: false
name: NDUFS1

metaR r0202
type: Reaction
kinetic law: MODEL1310110022#
fast: false
product: MODEL1310110022#
reversible: true
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
is: SBO:0000176
reactant: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_e51a5d78_1af5_4617_8bf7_6c3919fdcad4
name: CHDH
is encoded by: hsa:55349
boundary condition: true
is: SBO:0000252
is: Q8NE62
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaR r0963
is described by: ECO:0000000
reactant: MODEL1310110022#
product: MODEL1310110022#
type: Reaction
name: Facilitated diffusion
is: SBO:0000185
fast: false
kinetic law: MODEL1310110022#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:

metaM hs deg23 l
has only substance units: false
initial concentration: 1.0
name: GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
type: Species
notes: FORMULA: C31H49NO29S CHARGE: -2
is: SBO:0000247
is: HMDB02704
is: CHEBI:21338
constant: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110022#_38d50659_0259_4cdb_85fc_1350e067c30a
is: Q9UHI7
type: Species
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: SLC23A1
is encoded by: hsa:9963

metaR CHSTEROLt1
is described by: ECO:0000304
name: cholesterol intracellular transport
is: SBO:0000185
product: MODEL1310110022#
fast: false
reactant: MODEL1310110022#
modifier: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?
reversible: true
kinetic law: MODEL1310110022#

metaR ILETA
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
reversible: true
name: isoleucine transaminase
product: MODEL1310110022#
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.6.1.42
is described by: ECO:0000269

metaR PCHOL HStg
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
reversible: true
type: Reaction
kinetic law: MODEL1310110022#
is: SBO:0000185
name: phosphatidylcholine scramblase
fast: false
product: MODEL1310110022#
is described by: ECO:0000000

metaR r1553
reactant: MODEL1310110022#
type: Reaction
kinetic law: MODEL1310110022#
fast: false
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM 10fthf5glu l
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C40H45N11O19 CHARGE: -6
name: 10-formyltetrahydrofolate-[Glu](5)
initial amount: NaN
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110022#_142b32c8_7f80_4e5e_8d19_5d4105c64e64
is: SBO:0000252
boundary condition: true
is: Q6IZA2
is encoded by: hsa:2523
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: FUT1
type: Species

metaR FUMAC
modifier: MODEL1310110022#
reactant: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: (2184.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.7.1.2 Confidence Level: 4 AUTHORS: NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110022#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.7.1.2
name: fumarylacetoacetase
product: MODEL1310110022#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110022#_37875602_6747_4d0a_9d6c_3026a26c2688
is encoded by: hsa:229
name: ALDOB
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is: P05062
is: SBO:0000252

metaM ksi deg9 l
notes: FORMULA: C188H301N13O166S10 CHARGE: -10
is: SBO:0000247
is: CHEBI:12936
initial concentration: 1.0
boundary condition: false
is: HMDB00143
type: Species
name: keratan sulfate I, degradation product 9
has only substance units: false
constant: false
initial amount: NaN

metaM ump c
is: HMDB00288
is: C00105
name: UMP
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57865
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
boundary condition: false
is: SBO:0000247
constant: false
type: Species
has only substance units: false

metaR O2ter
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000000
kinetic law: MODEL1310110022#
name: O2 transport, endoplasmic reticulum
fast: false

metaR MCITS
kinetic law: MODEL1310110022#
fast: false
is: SBO:0000176
type: Reaction
name: 2-methylcitrate synthase
product: MODEL1310110022#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 2.3.3.5 Confidence Level: 2 AUTHORS: PMID:426765,PMID:4507604 NOTES:NCD new EC is 2.3.3.5 - NCD
reactant: MODEL1310110022#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110022#_f9dfec22_80b2_4a1b_a8cf_b0e90f14838a
has only substance units: false
boundary condition: true
is: SBO:0000252
name: ALDH7A1
is: E7EPT3
constant: false
is encoded by: hsa:501
initial concentration: NaN
type: Species
initial amount: NaN

metaR P45027A1m
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.15
product: MODEL1310110022#
type: Reaction
modifier: MODEL1310110022#
reversible: false
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
reactant: MODEL1310110022#
name: Cytochrome P450 27
is described by: ECO:0000269

metaM glyclt x
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB00115
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
name: glycolate
is: CHEBI:29805
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160

http://identifiers.org/biomodels.db/MODEL1310110022#_4c54283a_a559_4828_bf4f_2070c1c1c7f1
has only substance units: false
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:3295
initial amount: NaN
boundary condition: true
name: HSD17B4
is: E9PB82
initial concentration: NaN

metaM ca2 c
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:29108
name: calcium(2+)
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB00464
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_3220a9b6_f518_4a77_88e6_1aa61604ae5b
name: CTPS2
boundary condition: true
is encoded by: hsa:56474
is: SBO:0000252
is: Q9NRF8
type: Species
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_ab7fbb49_13c6_48c3_adc7_4739ac4fe846
name: _AI926493_1_c
boundary condition: true
is encoded by: hsa:AI926493
has only substance units: false
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR FBA
modifier: MODEL1310110022#
reversible: true
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (230.1) or (229.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:12626877,PMID:6765112 NOTES:6765112 - fluorescence of presence in human brain
name: fructose-bisphosphate aldolase
is version of: http://identifiers.org/ec-code/4.1.2.13
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
fast: false
is: SBO:0000176
is described by: ECO:0000134
type: Reaction
product: MODEL1310110022#

metaM acnam c
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
initial amount: NaN
is: CHEBI:35418
is: HMDB00230
name: N-acetylneuraminate
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species

metaM HC00695 m
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
name: S-Succinyldihydrolipoamide
boundary condition: false
is: CHEBI:17432
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
type: Species
initial amount: NaN

metaM ttdca e
constant: false
is: HMDB00806
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:30807
is: C06424
type: Species
name: tetradecanoate (n-C14:0)
notes: FORMULA: C14H27O2 CHARGE: -1 EHMN_ABBREVIATION: C06424
has only substance units: false
initial concentration: 1.0

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

metaM ppi x
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
has only substance units: false
type: Species
is: C00013
is: SBO:0000247
is: HMDB00250
name: Diphosphate
is: CHEBI:33019
initial concentration: 1.0

metaM core6 l
has only substance units: false
type: Species
name: Core 6
is: SBO:0000247
notes: FORMULA: C16H27N2O10X CHARGE: 0
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB00143
initial amount: NaN
is: CHEBI:12936

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_27551c20_f210_4fdb_90d6_e3012c5dfc90
type: Species
initial amount: NaN
is: SBO:0000252
name: CPT1B
initial concentration: NaN
is encoded by: hsa:1375
constant: false
is: E9PCP2
boundary condition: true
has only substance units: false

metaR r1551
reactant: MODEL1310110022#
type: Reaction
fast: false
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110022#

metaM xu5p D c
is: HMDB00868
is: SBO:0000247
has only substance units: false
is: CHEBI:57737
name: D-xylulose 5-phosphate(2-)
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
initial amount: NaN
boundary condition: false

metaR EX xylt LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for xylitol
type: Reaction

metaR DM anth
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

metaR SMS
is: SBO:0000176
name: Sphingomyelin synthase (homo sapiens)
reversible: false
is version of: http://identifiers.org/ec-code/2.7.8.27
fast: false
product: MODEL1310110022#
is described by: ECO:0000269
reactant: MODEL1310110022#
type: Reaction
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (259230.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14685263 NOTES:NJ
modifier: MODEL1310110022#

metaM sphmyln hs g
initial amount: NaN
is: CHEBI:58216
is: SBO:0000247
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
name: sphingomyelin betaine
constant: false

metaR CHSTEROLt3
is described by: ECO:0000000
reactant: MODEL1310110022#
fast: false
is: SBO:0000185
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reversible: true
kinetic law: MODEL1310110022#
type: Reaction
name: cholesterol intracellular transport

metaM ocdcea c
type: Species
is: SBO:0000247
is: HMDB00207
name: octadecenoate (n-C18:1)
boundary condition: false
is: C00712
constant: false
initial concentration: 1.0
notes: FORMULA: C18H33O2 CHARGE: -1
initial amount: NaN
is: CHEBI:0
has only substance units: false

metaR r2411
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
is: SBO:0000185
product: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000000
kinetic law: MODEL1310110022#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_0d5abd4c_28f5_48ee_be13_52678ffbad09
is: O00219
has only substance units: false
type: Species
is: SBO:0000252
constant: false
name: HAS3
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:3038

http://identifiers.org/biomodels.db/MODEL1310110022#_cfee49d1_fb13_4687_bf75_0f9b6b728937
initial amount: NaN
has only substance units: false
is: Q9NRR6
constant: false
name: INPP5E
is encoded by: hsa:56623
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species

metaR BILIRUBt2
is: SBO:0000185
product: MODEL1310110022#
kinetic law: MODEL1310110022#
is described by: ECO:0000269
fast: false
name: bilirubin transport via bicarbonate countertransport
type: Reaction
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
modifier: MODEL1310110022#
reversible: true
reactant: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_d93655fd_ecb7_45f1_96e6_a868cbc979b7
is: SBO:0000252
is: P17516
name: AKR1C4
boundary condition: true
type: Species
is encoded by: hsa:1109
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false

metaM HC01162 c
initial amount: NaN
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
has only substance units: false
is: CHEBI:58376
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaM leuktrB4 c
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB01085
boundary condition: false
name: leukotriene B4(1-)
is: SBO:0000247
initial amount: NaN
is: CHEBI:57461
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
type: Species

metaR TRIODTHYt2
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
reversible: true
reactant: MODEL1310110022#
is: SBO:0000185
product: MODEL1310110022#
is described by: ECO:0000269
name: T3 transport via facilitated diffusion
type: Reaction
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
fast: false

metaM fad r
is: HMDB01248
boundary condition: false
name: Flavin adenine dinucleotide oxidized
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:16238

metaR r0547
fast: false
is described by: ECO:0000000
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
product: MODEL1310110022#
name: Aldehyde:NADP+ oxidoreductase Phenylalanine metabolism EC:1.2.1.5
kinetic law: MODEL1310110022#
reversible: true
type: Reaction
is: SBO:0000176
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.17.1.4

http://identifiers.org/biomodels.db/MODEL1310110022#_510c7d90_c9eb_413a_bca6_7b9c3c5209b7
is: SBO:0000252
is encoded by: hsa:PRO1933
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
type: Species
name: _PRO1933_1_m

metaR GLYCLTtp
kinetic law: MODEL1310110022#
is: SBO:0000185
product: MODEL1310110022#
name: glycolate transport into peroxisome
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
reversible: false
reactant: MODEL1310110022#
type: Reaction
fast: false

metaR CHSTEROLt2
name: cholesterol intracellular transport
reactant: MODEL1310110022#
fast: false
reversible: true
product: MODEL1310110022#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is described by: ECO:0000000
kinetic law: MODEL1310110022#

metaM dhcholestanate c
boundary condition: false
type: Species
is: HMDB00359
has only substance units: false
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
constant: false
initial amount: NaN
is: CHEBI:16577
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
initial concentration: 1.0
is: SBO:0000247

metaR RE1796R
reactant: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.145
modifier: MODEL1310110022#
is described by: ECO:0000000
kinetic law: MODEL1310110022#
is: SBO:0000176
fast: false
product: MODEL1310110022#
name: RE1796
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110022#_afa9c65c_dfca_4ace_9206_055f919ba819
name: _D29675_1_c
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:D29675
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_697ad634_6df2_43ee_864a_553768c36d86
name: _AI990637_1_x
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:AI990637
constant: false
initial concentration: NaN
is: SBO:0000252

metaR LEUPHELAT2tc
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_33c9b853_a5f6_4e82_bb1d_48ac2398c3a7
is encoded by: hsa:3030
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
is: E9KL44
name: HADHA
type: Species
initial amount: NaN
constant: false

metaR HISCAT1
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

metaM 4abut n
is: C00334
is: SBO:0000247
constant: false
name: 4-Aminobutanoate
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB00112
notes: FORMULA: C4H9NO2 CHARGE: 0
boundary condition: false

metaR EX 3mop LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxopentanoate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_d8ae63c3_5bcf_4837_a2db_d2a150dc20ca
has only substance units: false
type: Species
constant: false
is: Q8N4A0
initial concentration: NaN
is encoded by: hsa:8693
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: GALNT4

metaM pchol hs g
initial concentration: 1.0
constant: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
is: CHEBI:16110
boundary condition: false
initial amount: NaN
has only substance units: false
name: Phosphatidylcholine
type: Species
is: SBO:0000247

metaR GLCNACASE3ly
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.50
product: MODEL1310110022#
name: alpha-N-acetylglucosaminidase, lysosomal
type: Reaction
reversible: false
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#

metaM CE2838 e
is: C01936
has only substance units: false
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
boundary condition: false
is: http://identifiers.org/pubchem.compound/5041
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
name: maltononaose

metaM co c
initial amount: NaN
is: CHEBI:17245
name: carbon monoxide
boundary condition: false
constant: false
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
initial concentration: 1.0
is: HMDB01361
is: SBO:0000247
type: Species
has only substance units: false

metaM C05957 r
type: Species
name: Prostaglandin J2
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB02710
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
is: CHEBI:27485

metaR r1538
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
name: Anion Exchanger (AE) TCDB:2.A.31.2.8
reversible: false
fast: false
type: Reaction
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.17.4.1
is: SBO:0000185
kinetic law: MODEL1310110022#
product: MODEL1310110022#
is described by: ECO:0000000
modifier: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_a8cfa855_4dff_49d2_a015_4e8d1d590780
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: BTD
is: SBO:0000252
type: Species
is: P43251
is encoded by: hsa:686
boundary condition: true

metaM gdp g
boundary condition: false
has only substance units: false
constant: false
type: Species
is: CHEBI:58189
name: GDP(3-)
is: SBO:0000247
initial concentration: 1.0
is: HMDB01201
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
initial amount: NaN

metaM ocdcea e
is: C00712
notes: FORMULA: C18H33O2 CHARGE: -1
is: SBO:0000247
initial amount: NaN
is: HMDB00207
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:0
constant: false
name: octadecenoate (n-C18:1)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110022#_df7e7fc6_55e3_420b_ba15_11bde16993a1
initial concentration: NaN
name: _AI697028_1_e
type: Species
constant: false
is encoded by: hsa:AI697028
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaM 9 cis retfa e
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
name: fatty acid 9-cis-retinol
is: SBO:0000247
is: HMDB06559
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species

metaR HIStN1
reversible: true
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
kinetic law: MODEL1310110022#
product: MODEL1310110022#
is: SBO:0000185
name: Histidine transport (Na, H coupled)
reactant: MODEL1310110022#
fast: false
modifier: MODEL1310110022#
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_be80e74f_5dcf_4889_9318_511c64bfaac3
is: O95167
constant: false
is: SBO:0000252
name: NDUFA3
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:4696

metaR GLYt7 211 r
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
name: glycine reversible transport via sodium and chloride symport (2:1:1)
is described by: ECO:0000269
modifier: MODEL1310110022#
reactant: MODEL1310110022#
type: Reaction
product: MODEL1310110022#
kinetic law: MODEL1310110022#

metaR PUNP7
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.1
name: purine-nucleoside phosphorylase (Xanthosine)
kinetic law: MODEL1310110022#
reversible: true
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
reactant: MODEL1310110022#
type: Reaction
product: MODEL1310110022#
is: SBO:0000176
is described by: ECO:0000269

metaM ksi deg3 l
is: CHEBI:57312
is: HMDB01356
type: Species
name: keratan sulfate I, degradation product 3
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C233H371N16O205S12 CHARGE: -13
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaM 4abut m
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
is: CHEBI:16865
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB00112
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
name: 4-Aminobutanoate
is: C00334

metaM leuktrB4 e
type: Species
name: leukotriene B4(1-)
is: HMDB01085
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:57461

metaR PROt2r
name: L-proline reversible transport via proton symport
modifier: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
fast: false
product: MODEL1310110022#
reversible: true
kinetic law: MODEL1310110022#
is described by: ECO:0000304
type: Reaction
is: SBO:0000185

metaM 10fthf6glu m
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
name: 10-formyltetrahydrofolate-[Glu](6)

metaR r0549
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
is version of: http://identifiers.org/ec-code/1.6.99.3
is version of: http://identifiers.org/ec-code/6.1.1.17
product: MODEL1310110022#
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
modifier: MODEL1310110022#
type: Reaction
reversible: true
is: SBO:0000176
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.6.5.3
kinetic law: MODEL1310110022#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110022#_1132f343_9ab2_4a94_824a_fb1c08bf1a8f
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
name: _U37519_1_m
initial concentration: NaN
is encoded by: hsa:U37519

metaM zymstnl r
is: HMDB06841
type: Species
initial amount: NaN
is: CHEBI:16608
name: 5alpha-cholest-8-en-3beta-ol
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false

metaM lthstrl r
boundary condition: false
name: 5alpha-cholest-7-en-3beta-ol
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB01170
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189
is: CHEBI:17168
type: Species
has only substance units: false

metaR F1PGT
is: SBO:0000176
product: MODEL1310110022#
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (8790.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.30 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: true
name: fucose-1-phosphate guanylyltransferase
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.7.7.30

http://identifiers.org/biomodels.db/MODEL1310110022#_17759042_995f_417d_a791_f38549e4a124
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1103
type: Species
initial concentration: NaN
is: P28329
name: CHAT
constant: false

metaR r1298
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000185
reversible: false
product: MODEL1310110022#
name: Vesicular transport

metaM citr L e
initial amount: NaN
name: citr_L[e]
constant: false
is: CHEBI:16349
has only substance units: false
boundary condition: false
is: HMDB00904
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277

metaR ALAGLYexR
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110022#
is described by: ECO:0000304
fast: false
product: MODEL1310110022#
modifier: MODEL1310110022#
is: SBO:0000185
reactant: MODEL1310110022#
name: L-alanine/glycine reversible exchange
reversible: true

metaR MI145PP
product: MODEL1310110022#
type: Reaction
fast: false
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.1.3.86
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
reversible: false
modifier: MODEL1310110022#
is described by: ECO:0000269
name: inositol-1,4,5-trisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.36
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.56

http://identifiers.org/biomodels.db/MODEL1310110022#_10d3f671_fa39_4bc6_864b_90c916b5f067
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:51102
name: MECR
has only substance units: false
is: Q9BV79

http://identifiers.org/biomodels.db/MODEL1310110022#_eb558d2b_baad_46b4_917f_ede306043cca
type: Species
has only substance units: false
is encoded by: hsa:27124
initial amount: NaN
boundary condition: true
constant: false
name: INPP5J
is: SBO:0000252
initial concentration: NaN

metaR 2HBt2
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
name: 2-hydroxybutyrate cotransport with proton
fast: false
product: MODEL1310110022#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110022#
reversible: true
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
is described by: ECO:0000269

metaR r1429
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
type: Reaction
product: MODEL1310110022#
reversible: true
reactant: MODEL1310110022#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110022#
name: Free diffusion
is: SBO:0000185

metaR F1Atg
reactant: MODEL1310110022#
name: F1alpha transport (from golgi to lysosome)
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110022#
reversible: true
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110022#_735e76d5_8b46_4dcb_aa55_fb4a6de37b22
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6526
constant: false
is: P53794
type: Species
name: SLC5A3
initial amount: NaN

metaM adn c
has only substance units: false
initial amount: NaN
boundary condition: false
is: C00212
type: Species
is: HMDB00050
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
is: SBO:0000247
initial concentration: 1.0
name: Adenosine
constant: false
is: CHEBI:16335

metaM ditp c
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: dITP(4-)
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
has only substance units: false
is: CHEBI:61382
is: HMDB03537

metaM 10fthf6glu l
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
name: 10-formyltetrahydrofolate-[Glu](6)
initial amount: NaN
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110022#_87eeafc9_d99a_4999_85fb_723786ffe794
type: Species
is: SBO:0000252
name: G6PC3
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: Q9BUM1
constant: false
is encoded by: hsa:92579
has only substance units: false

metaR PROSTGH2t
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
type: Reaction
product: MODEL1310110022#
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
name: Prostaglandin H2 transport
is: SBO:0000185
is described by: ECO:0000269
reversible: true

metaM retn r
constant: false
is: CHEBI:35291
type: Species
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
has only substance units: false
is: SBO:0000247
name: all-trans-retinoate
initial amount: NaN
is: HMDB01852
initial concentration: 1.0
boundary condition: false

metaR SPC HSt
product: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069827 NOTES:
is described by: ECO:0000000
name: sphingosylphosphorylcholine transport (diffusion)
fast: false
is: SBO:0000185
kinetic law: MODEL1310110022#
type: Reaction
reversible: true

metaR UMPK4n
name: UMP kinase (GTP),nuclear
fast: false
is: SBO:0000176
reactant: MODEL1310110022#
reversible: true
product: MODEL1310110022#
modifier: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269

metaM HC02202 c
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:57398
name: prostaglandin A1(1-)
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
has only substance units: false
initial amount: NaN

metaM apoC Lys m
name: Apocarboxylase (Lys residue)
boundary condition: false
constant: false
notes: FORMULA: C6H13N2OX CHARGE: 0
has only substance units: false
is: SBO:0000247
is: HMDB00182
initial concentration: 1.0
initial amount: NaN
is: CHEBI:32551
type: Species

metaR r2045
kinetic law: MODEL1310110022#
type: Reaction
is: SBO:0000185
product: MODEL1310110022#
reversible: false
fast: false
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000

metaR r1291
is: SBO:0000185
fast: false
product: MODEL1310110022#
is described by: ECO:0000000
reactant: MODEL1310110022#
name: Postulated transport reaction
reversible: true
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
type: Reaction

metaR ALDD2x
type: Reaction
fast: false
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.2.1.36
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110022#
modifier: MODEL1310110022#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110022#
name: aldehyde dehydrogenase (acetaldehyde, NAD)
reversible: false
notes: GENE_ASSOCIATION: (218.1) or (501.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (223.1) or (220.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:Only acetaldehyde considered for now. See also 1.2.1.4. Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. Formerly EC 1.1.1.70; r0176
is described by: ECO:0000000

metaR LSTO2r
product: MODEL1310110022#
reactant: MODEL1310110022#
type: Reaction
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110022#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.21.6
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
name: Lathosterol oxidase
fast: false
modifier: MODEL1310110022#

metaR CYTK2n
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
fast: false
is described by: ECO:0000269
product: MODEL1310110022#
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
name: cytidylate kinase (dCMP),nuclear
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110022#_b2ed8fe0_3b58_4e68_a696_52a799b212b0
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:79646
is: Q9H999
name: PANK3
has only substance units: false
initial concentration: NaN

metaM pan4p m
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
is: HMDB01416
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:47942
name: pantetheine 4'-phosphate(2-)
initial amount: NaN

metaR r1428
name: Free diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
reactant: MODEL1310110022#
fast: false
type: Reaction
kinetic law: MODEL1310110022#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110022#

metaM grdp x
boundary condition: false
constant: false
type: Species
notes: FORMULA: C10H17O7P2 CHARGE: -3 INCHI: InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/p-3/b10-7+ HEPATONET_1.0_ABBREVIATION: HC00288 EHMN_ABBREVIATION: C00341
name: geranyl diphosphate(3-)
initial amount: NaN
is: HMDB01285
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58057

metaR PUNP5
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.1
name: purine-nucleoside phosphorylase (Inosine)
reversible: true
product: MODEL1310110022#
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
modifier: MODEL1310110022#
reactant: MODEL1310110022#
type: Reaction
is: SBO:0000176

metaM citr L c
name: L-citrulline
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:16349
constant: false
initial concentration: 1.0
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
is: HMDB00904
is: SBO:0000247

metaM dutp c
constant: false
is: CHEBI:17625
type: Species
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: SBO:0000247
is: HMDB01191
is: C00460
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: dUTP

metaR LEUKTRA4t
reversible: true
fast: false
name: leukotriene A4 transport
kinetic law: MODEL1310110022#
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:
reactant: MODEL1310110022#

metaR NDPK7n
reactant: MODEL1310110022#
fast: false
is: SBO:0000176
reversible: true
type: Reaction
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
modifier: MODEL1310110022#
product: MODEL1310110022#
kinetic law: MODEL1310110022#

metaR ALDD2y
is version of: http://identifiers.org/ec-code/1.2.1.36
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (223.1) or (221.1) or (218.1) or (8854.1) or (8854.3) or (222.1) or (8854.2) or (224.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.4 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:See also ALDH1 (1.2.1.3); r0177
modifier: MODEL1310110022#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
kinetic law: MODEL1310110022#
is described by: ECO:0000000
name: aldehyde dehydrogenase (acetaldehyde, NADP)
type: Reaction
reactant: MODEL1310110022#
product: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_12b65352_76bf_4e6c_94bc_5394afd5823f
initial concentration: NaN
constant: false
is: SBO:0000252
is: Q02127
is encoded by: hsa:1723
type: Species
has only substance units: false
boundary condition: true
name: DHODH
initial amount: NaN

metaM pchol hs c
name: Phosphatidylcholine
is: CHEBI:16110
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN

metaR r2416
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:8132483 NOTES:
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

metaR BETALDHxm
reversible: false
is: SBO:0000176
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 2 AUTHORS: PMID:15321791 NOTES:MM
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110022#
name: betaine-aldehyde dehydrogenase, mitochondrial
product: MODEL1310110022#

metaR r1427
product: MODEL1310110022#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
reversible: false
reactant: MODEL1310110022#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110022#

metaR PUNP6
reactant: MODEL1310110022#
product: MODEL1310110022#
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.4.2.1
reversible: true
type: Reaction
modifier: MODEL1310110022#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is described by: ECO:0000269
fast: false
name: purine-nucleoside phosphorylase (Deoxyinosine)

metaR CITRtm
name: citrulline mitochondrial transport via proton antiport
fast: false
reversible: true
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110022#
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
product: MODEL1310110022#
is: SBO:0000185
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV

metaM HC02202 e
has only substance units: false
type: Species
is: CHEBI:57398
initial concentration: 1.0
is: SBO:0000247
name: prostaglandin A1(1-)
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
initial amount: NaN
constant: false

metaR PAIL HStn
reversible: true
name: phosphatidylinositol nuclear transport (diffusion)
reactant: MODEL1310110022#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
kinetic law: MODEL1310110022#
product: MODEL1310110022#
is described by: ECO:0000000
is: SBO:0000185

metaM ile L m
is: CHEBI:17191
boundary condition: false
is: HMDB00172
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: L-isoleucine
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_125e0699_b6a6_43a9_a48d_2963612e1684
type: Species
has only substance units: false
is: SBO:0000252
name: _AI480132_1_c
is encoded by: hsa:AI480132
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

metaR EX drib LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Deoxyribose exchange
type: Reaction

metaR r0545
is described by: ECO:0000000
kinetic law: MODEL1310110022#
product: MODEL1310110022#
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
reactant: MODEL1310110022#
modifier: MODEL1310110022#
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.5
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
reversible: true

metaM gdp c
is: SBO:0000247
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
type: Species
has only substance units: false
constant: false
boundary condition: false
name: GDP
is: HMDB01201
is: CHEBI:58189
initial amount: NaN
initial concentration: 1.0
is: C00035

metaR GLUDxm
is version of: http://identifiers.org/ec-code/1.4.1.3
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
is: SBO:0000176
reversible: true
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110022#
name: glutamate dehydrogenase (NAD) (mitochondrial)
reactant: MODEL1310110022#
fast: false
product: MODEL1310110022#
modifier: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_47723075_28d7_4729_aeb7_c13d23eb62a3
name: NDUFB10
is: SBO:0000252
initial concentration: NaN
constant: false
is: A8K761
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:4716

metaR PUNP3
modifier: MODEL1310110022#
reactant: MODEL1310110022#
product: MODEL1310110022#
name: purine-nucleoside phosphorylase (Guanosine)
fast: false
kinetic law: MODEL1310110022#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.1

http://identifiers.org/biomodels.db/MODEL1310110022#_fd3c1b46_07b7_41c8_b54d_d9c99ceab59c
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
name: GALE
is: Q38G75
is encoded by: hsa:2582
type: Species
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_9a943ec2_0655_447c_99a6_7bb8ce9c1d29
boundary condition: true
is: Q9UEF7
initial amount: NaN
type: Species
is: SBO:0000252
name: KL
initial concentration: NaN
has only substance units: false
is encoded by: hsa:9365
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_0f3ed0ae_db97_4d4c_b664_b805a8fd0ac7
initial concentration: NaN
is: Q53H96
is: SBO:0000252
constant: false
initial amount: NaN
name: PYCRL
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:65263

http://identifiers.org/biomodels.db/MODEL1310110022#_7be31fe8_5087_4531_8e0c_73a628dd5c54
name: PLCG1
is encoded by: hsa:5335
is: SBO:0000252
type: Species
is: P19174
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true

metaM nicrns c
boundary condition: false
is: CHEBI:58527
is: HMDB06809
notes: FORMULA: C11H13NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01628 EHMN_ABBREVIATION: C05841
has only substance units: false
initial amount: NaN
name: Nicotinate D-ribonucleoside
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247

metaM frdp r
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB00961
initial amount: NaN
name: Farnesyl diphosphate
is: C00448
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:175763

metaR RPEc
type: Reaction
name: ribulose 5-phosphate 3-epimerase
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
is described by: ECO:0000134
kinetic law: MODEL1310110022#
reversible: true
product: MODEL1310110022#
is: SBO:0000176
fast: false
reactant: MODEL1310110022#

metaM trdrd m
constant: false
boundary condition: false
name: Reduced thioredoxin
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
is: CHEBI:15967
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species

metaR LPCOXp
name: L-pipecolate oxidase, peroxisomal
type: Reaction
is: SBO:0000176
fast: false
modifier: MODEL1310110022#
reversible: false
reactant: MODEL1310110022#
is described by: ECO:0000269
kinetic law: MODEL1310110022#
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.5.3.1
notes: GENE_ASSOCIATION: (51268.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.3.7 Confidence Level: 4 AUTHORS: PMID:10772957 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110022#_53ba3438_d781_41ab_b876_703ec7cd16ca
type: Species
has only substance units: false
constant: false
boundary condition: true
is: Q15111
name: PLCL1
is: SBO:0000252
is encoded by: hsa:5334
initial amount: NaN
initial concentration: NaN

metaM 5pmev c
name: (R)-5-phosphonatomevalonate(3-)
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H10O7P CHARGE: -3 INCHI: InChI=1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/p-3/t6-/m1/s1
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: HMDB01343

metaM 10fthf5glu e
initial amount: NaN
constant: false
has only substance units: false
name: 10-formyltetrahydrofolate-[Glu](5)
initial concentration: 1.0
is: CHEBI:57454
type: Species
is: SBO:0000247
notes: FORMULA: C40H45N11O19 CHARGE: -6
boundary condition: false
is: HMDB00972

metaR FUMSO3tm
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is: SBO:0000185
kinetic law: MODEL1310110022#
is described by: ECO:0000269
reversible: true
product: MODEL1310110022#
name: Fumarate:sulfite antiport, mitochondrial
type: Reaction
modifier: MODEL1310110022#
fast: false
reactant: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_daba27af_7de9_4e04_acfb_a5f38768ddc0
constant: false
is encoded by: hsa:257068
has only substance units: false
initial amount: NaN
name: PLCXD2
is: SBO:0000252
is: Q0VAA5
type: Species
initial concentration: NaN
boundary condition: true

metaR GLYCt
fast: false
is: SBO:0000185
product: MODEL1310110022#
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000000
name: glycerol transport via channel
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
reversible: true

metaM CE2866 c
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C15H13I2NO4 CHARGE: 0 INCHI: InChI=1S/C15H13I2NO4/c16-10-7-9(2-3-13(10)19)22-14-4-1-8(5-11(14)17)6-12(18)15(20)21/h1-5,7,12,19H,6,18H2,(H,20,21)/t12-/m0/s1 EHMN_ABBREVIATION: CE2866
initial concentration: 1.0
type: Species
name: 3,3'-diiodo-L-thyronine
has only substance units: false
initial amount: NaN
is: CHEBI:45698

http://identifiers.org/biomodels.db/MODEL1310110022#_cc1ccbf0_10ff_44a3_bba1_2d4f588b74b7
boundary condition: true
name: SYNJ1
initial concentration: NaN
type: Species
is: O43426
is: SBO:0000252
has only substance units: false
is encoded by: hsa:8867
constant: false
initial amount: NaN

metaR EX docosdiac
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for docosanedioic acid
type: Reaction

metaM HC00460 c
name: 2,5-dihydroxybenzoate
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
boundary condition: false
is: CHEBI:58044

metaM 2mp2coa m
type: Species
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
has only substance units: false
is: HMDB01011
initial amount: NaN
initial concentration: 1.0
is: CHEBI:27754
name: 2-Methylprop-2-enoyl-CoA

metaR BACCLm
is: SBO:0000176
is described by: ECO:0000254
fast: false
name: biotin-[acetyl-CoA-carboxylase] ligase, mitochondrial
reversible: false
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.4.10
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 2 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110022#_dabb039d_8566_4d7d_8707_b3fe588eda20
boundary condition: true
name: _AI972237_1_c
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:AI972237
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_2e4cd526_ad7a_4958_871c_31446c0c57f7
constant: false
boundary condition: true
is encoded by: hsa:3037
is: Q92819
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
name: HAS2
is: SBO:0000252

metaR EX biocyt LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biocytin exchange
type: Reaction

metaR GGT6
is: SBO:0000176
is described by: ECO:0000000
name: Gamma-glutamyltransferase
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
type: Reaction
kinetic law: MODEL1310110022#
fast: false
product: MODEL1310110022#
reactant: MODEL1310110022#
reversible: true

metaR ACALDtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:9028626 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110022#
name: acetaldehyde mitochondrial diffusion
is: SBO:0000185
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110022#
product: MODEL1310110022#

metaR PUNP4
kinetic law: MODEL1310110022#
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.4.2.1
reactant: MODEL1310110022#
reversible: true
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
name: purine-nucleoside phosphorylase (Deoxyguanosine)
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110022#_13889063_d2c6_4157_a896_3947518233d5
initial concentration: NaN
initial amount: NaN
name: _AA526438_1_c
boundary condition: true
is encoded by: hsa:AA526438
is: SBO:0000252
type: Species
has only substance units: false
constant: false

metaM 4mop c
is: CHEBI:17865
has only substance units: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
initial amount: NaN
constant: false
is: HMDB00695
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
name: 4-methyl-2-oxopentanoate

metaM ethamp c
is: CHEBI:58190
has only substance units: false
name: ethamp[c]
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB00224
constant: false
boundary condition: false
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
initial concentration: 1.0

metaR DADNt4
reactant: MODEL1310110022#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is described by: ECO:0000000
reversible: true
product: MODEL1310110022#
kinetic law: MODEL1310110022#
name: deoxyadenosine transport via diffusion
type: Reaction

metaM ura c
is: HMDB00300
is: CHEBI:17568
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: C00106
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
name: Uracil

metaR PUNP1
is version of: http://identifiers.org/ec-code/2.4.2.1
modifier: MODEL1310110022#
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
name: purine-nucleoside phosphorylase (Adenosine)
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110022#

metaR r1644
fast: false
reactant: MODEL1310110022#
is: SBO:0000185
product: MODEL1310110022#
type: Reaction
modifier: MODEL1310110022#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110022#

metaM sphs1p e
is: HMDB00277
is: SBO:0000247
has only substance units: false
name: sphingosine 1-phosphate(1-)
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:60119
boundary condition: false

metaM dopa c
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
constant: false
has only substance units: false
initial concentration: 1.0
name: dopaminium(1+)
is: CHEBI:59905
initial amount: NaN
is: HMDB00073

metaR r2385
reactant: MODEL1310110022#
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110022#
is: SBO:0000185
is described by: ECO:0000000
fast: false
type: Reaction
reversible: false
product: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_429e0e3d_c3b4_4959_bde0_9b8a1421c6e8
boundary condition: true
has only substance units: false
type: Species
constant: false
is: Q6IBC4
initial concentration: NaN
is encoded by: hsa:4726
name: NDUFS6
is: SBO:0000252
initial amount: NaN

metaM 6dhf e
is: SBO:0000247
initial concentration: 1.0
is: HMDB06563
initial amount: NaN
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
name: hexaglutamyl folate (DHF)
type: Species
has only substance units: false
constant: false
boundary condition: false

metaM gdp m
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
initial concentration: 1.0
has only substance units: false
name: GDP
is: SBO:0000247
is: HMDB01201
is: C00035
initial amount: NaN
type: Species
is: CHEBI:58189
constant: false
boundary condition: false

metaM ditp n
boundary condition: false
is: CHEBI:61382
initial amount: NaN
name: dITP(4-)
initial concentration: 1.0
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
has only substance units: false
is: HMDB03537
constant: false
type: Species
is: SBO:0000247

metaM cortsn r
is: HMDB02802
name: cortisone
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C21H28O5 CHARGE: 0 INCHI: InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1 EHMN_ABBREVIATION: C00762
type: Species
initial amount: NaN
is: CHEBI:16962

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

metaR CERT1rt
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
kinetic law: MODEL1310110022#
is: SBO:0000185
name: ceramide transport protein
is version of: http://identifiers.org/ec-code/2.7.11.1
modifier: MODEL1310110022#
is described by: ECO:0000304
reactant: MODEL1310110022#
reversible: true
type: Reaction
fast: false

metaR GULN3D
name: L-gulonate 3-dehydrogenase
is described by: ECO:0000000
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000176
reversible: true
fast: false
type: Reaction

metaR NDPK3n
reversible: true
name: nucleoside-diphosphate kinase (ATP:CDP),nuclear
is described by: ECO:0000304
reactant: MODEL1310110022#
fast: false
modifier: MODEL1310110022#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110022#
type: Reaction
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus

http://identifiers.org/biomodels.db/MODEL1310110022#_984fdf41_e5cd_4c53_b39b_a3f4146bfe9d
constant: false
name: SLC6A9
initial concentration: NaN
is encoded by: hsa:6536
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: P48067
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110022#_c065879a_2ba7_462e_87bd_0925b7c7c2a2
constant: false
has part: P31350
name: RRM1:RRM2
boundary condition: true
has part: P23921
has only substance units: false
is encoded by: hsa:6240
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000297
is encoded by: hsa:6241

metaR r1643
modifier: MODEL1310110022#
type: Reaction
product: MODEL1310110022#
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110022#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110022#

metaR PUNP2
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
fast: false
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.4.2.1
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
name: purine-nucleoside phosphorylase (Deoxyadenosine)
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
product: MODEL1310110022#
reversible: true

metaM retinal 11 cis c
initial concentration: 1.0
constant: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
type: Species
is: CHEBI:16066
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: 11-cis-retinal
is: HMDB02152
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_e7d1ae89_1f27_4599_9891_86506d3db9ee
is encoded by: hsa:1346
name: COX7A1
constant: false
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: P24310
initial amount: NaN

metaR PA HStg
type: Reaction
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
name: phosphatidate scramblase
reversible: true
product: MODEL1310110022#
kinetic law: MODEL1310110022#
is described by: ECO:0000000
is: SBO:0000185
fast: false

metaM hs deg16 l
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C49H72N2O54S4 CHARGE: -6
constant: false
is: HMDB02704
is: CHEBI:21338
name: heparan sulfate, degradation product 16
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110022#_6f0729b1_61f6_47f9_8c2e_95a7c16dbd8c
name: NAGA
is encoded by: hsa:4668
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
is: P17050
initial concentration: NaN

metaR r2384
type: Reaction
kinetic law: MODEL1310110022#
is: SBO:0000185
modifier: MODEL1310110022#
fast: false
reversible: false
product: MODEL1310110022#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110022#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110022#_311dbeff_2276_49cf_9bd1_8f5ac890b2a5
type: Species
name: LDHD
initial amount: NaN
boundary condition: true
is encoded by: hsa:197257
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: Q86WU2

metaR S6TASE2ly
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110022#
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.1.6.14
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
name: N-acetylglucosamine-6-sulfatase, lysosomal
reversible: true

metaM ura e
constant: false
is: HMDB00300
is: CHEBI:17568
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
type: Species
boundary condition: false
name: uracil

metaM gdp n
is: SBO:0000247
initial concentration: 1.0
is: HMDB01201
name: GDP(3-)
type: Species
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:58189
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_f27af635_de44_4621_96dc_57571e3f05d7
is encoded by: hsa:80270
boundary condition: true
constant: false
is: Q9H2F3
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: HSD3B7
has only substance units: false

metaR IDOAASE1ly
is: SBO:0000176
reactant: MODEL1310110022#
fast: false
product: MODEL1310110022#
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.2.1.76
reversible: false
name: alpha-L-iduronidase, lysosomal
type: Reaction
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
is described by: ECO:0000000

metaM citr L m
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
is: CHEBI:16349
name: L-citrulline
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB00904
initial amount: NaN

metaM dopa e
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:59905
name: dopaminium(1+)
is: HMDB00073
type: Species

metaR r1646
is: SBO:0000185
type: Reaction
product: MODEL1310110022#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110022#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r2387
kinetic law: MODEL1310110022#
fast: false
reactant: MODEL1310110022#
modifier: MODEL1310110022#
is: SBO:0000185
reversible: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110022#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

http://identifiers.org/biomodels.db/MODEL1310110022#_973206ae_15a9_4f9d_afa5_175c2becf44e
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:51292
constant: false
is: SBO:0000252
is: Q9P2T1
initial amount: NaN
name: GMPR2
boundary condition: true

metaR 3MOX4HOXPGALDOX NADP
is: SBO:0000176
product: MODEL1310110022#
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
reversible: true
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.2.1.5
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NADP+ oxidoreductase
type: Reaction
fast: false

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

metaR r0801
kinetic law: MODEL1310110022#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
product: MODEL1310110022#
reversible: true
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110022#

metaR S6TASE15ly
name: N-acetylglucosamine-6-sulfatase, lysosomal
is described by: ECO:0000000
reactant: MODEL1310110022#
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.1.6.14
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
type: Reaction
is: SBO:0000176
reversible: true
fast: false
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#

metaR r1645
type: Reaction
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
is described by: ECO:0000000
reactant: MODEL1310110022#
fast: false
is: SBO:0000185
product: MODEL1310110022#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110022#_64059c26_b275_43ee_a9df_ec4f6ccc61e8
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: PAPSS1
constant: false
initial amount: NaN
is: O43252
is encoded by: hsa:9061
has only substance units: false
type: Species

metaR r2386
is: SBO:0000185
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110022#
is described by: ECO:0000000
kinetic law: MODEL1310110022#
fast: false
type: Reaction
reactant: MODEL1310110022#

metaR ALAyLATthc
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Alanine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_15b07d75_349a_41f9_b73f_ab55ffd733a4
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000297
initial concentration: NaN
constant: false
has part: B4E3E9
is encoded by: hsa:4967
name: DLD:DLST:OGDH:PDHX
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_5f111873_025e_4924_93b3_73e1492e0f9d
has only substance units: false
is: Q99643
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:6391
name: SDHC

http://identifiers.org/biomodels.db/MODEL1310110022#_036a87c0_969e_4da5_8abe_0eb9bbc9e212
has only substance units: false
initial concentration: NaN
name: _AW299740_1_m
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AW299740
type: Species
boundary condition: true
constant: false

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_892b6179_c11f_4553_b2fc_a608039947c4
is: SBO:0000252
is encoded by: hsa:9563
is: O95479
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: H6PD
constant: false

metaR GLYCTO1p
kinetic law: MODEL1310110022#
fast: false
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (51179.1) or (54363.1) or (51179.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:tv NCD
product: MODEL1310110022#
name: Glycolate oxidase, peroxisome
type: Reaction
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.1.3.15
is: SBO:0000176

metaM frdp x
has only substance units: false
name: farnesyl pyrophosphate(3-)
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: CHEBI:175763
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB00961
type: Species

metaR r1648
type: Reaction
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110022#
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
product: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaR PPD2CSPp
reactant: MODEL1310110022#
reversible: false
name: PPD2CSPp
type: Reaction
kinetic law: MODEL1310110022#
is described by: ECO:0000000
product: MODEL1310110022#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:spontaneous cyclization reaction MM
fast: false

metaM itaccoa m
is: CHEBI:57381
constant: false
initial concentration: 1.0
type: Species
is: HMDB03377
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
name: itaconyl-CoA(5-)
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR r1109
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
product: MODEL1310110022#
reactant: MODEL1310110022#
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
is: SBO:0000176
kinetic law: MODEL1310110022#
is described by: ECO:0000000
fast: false
type: Reaction

metaR HS4ly
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110022#
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.10.1.1
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
is: SBO:0000176
type: Reaction
name: heparan-N-sulfatase, lysosomal
fast: false
kinetic law: MODEL1310110022#
product: MODEL1310110022#

metaM dutp m
type: Species
has only substance units: false
is: CHEBI:17625
initial concentration: 1.0
name: dUTP
initial amount: NaN
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
boundary condition: false
is: SBO:0000247
is: HMDB01191
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_aec17cb0_09e2_4659_914f_c8c4b33b50cd
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: SLC23A1
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:9963

metaM hs deg18 l
notes: FORMULA: C43H66N2O45S3 CHARGE: -4
initial amount: NaN
is: CHEBI:17180
has only substance units: false
is: HMDB01352
is: SBO:0000247
boundary condition: false
constant: false
name: heparan sulfate, degradation product 18
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_daa7ff72_d115_4d7e_b068_97a834a4283e
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:BG035985
type: Species
name: _BG035985_1_c
boundary condition: true
initial amount: NaN
has only substance units: false

metaM chsterol r
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:16113
initial concentration: 1.0
constant: false
name: cholesterol
is: HMDB00067
has only substance units: false
initial amount: NaN
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187

metaM orot e
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
is: CHEBI:30839
has only substance units: false
is: HMDB00226
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
name: orotate

http://identifiers.org/biomodels.db/MODEL1310110022#_575d48de_d7b2_40f0_9c7d_3fefde5c5ca5
initial amount: NaN
is: Q01968
name: OCRL
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:4952

http://identifiers.org/biomodels.db/MODEL1310110022#_818ce2b0_fead_4394_982c_d921c1db382b
name: NDUFA4L2
initial amount: NaN
is encoded by: hsa:56901
boundary condition: true
constant: false
is: Q9NRX3
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN

metaM dc2coa m
type: Species
boundary condition: false
is: CHEBI:61406
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: trans-Dec-2-enoyl-CoA
constant: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275
initial concentration: 1.0

metaR NACDe
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: release of nicotinate at the basolateral surface
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_68ddeeef_de2a_4fb1_be47_b46abe8fa9b5
is: SBO:0000252
initial concentration: NaN
name: RDH14
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:57665
is: Q9HBH5
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_fdb22401_42c4_47bb_a15d_19d66a5e01ff
initial concentration: NaN
name: CAD
has only substance units: false
is: SBO:0000252
is encoded by: hsa:790
constant: false
boundary condition: true
initial amount: NaN
type: Species
is: P27708

metaR r0178
is version of: http://identifiers.org/ec-code/2.5.1.21
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
type: Reaction
product: MODEL1310110022#
is described by: ECO:0000000
reactant: MODEL1310110022#
fast: false
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
is: SBO:0000176
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
reversible: true

metaR PSDm hs
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ
is described by: ECO:0000269
kinetic law: MODEL1310110022#
is: SBO:0000176
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/4.1.1.65
type: Reaction
reactant: MODEL1310110022#
fast: false
modifier: MODEL1310110022#
name: Phosphatidylserine decarboxylase
reversible: false

metaR r0179
type: Reaction
reversible: true
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16
modifier: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.27
kinetic law: MODEL1310110022#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
fast: false

metaR r1647
reversible: true
type: Reaction
modifier: MODEL1310110022#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110022#
product: MODEL1310110022#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

metaM 2dr1p c
has only substance units: false
type: Species
is: C00672
is: CHEBI:58576
is: HMDB01351
constant: false
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: 2-Deoxy-D-ribose 1-phosphate
initial concentration: 1.0

metaM 4mzym int1 r
notes: FORMULA: C29H46O3 CHARGE: 0 INCHI: InChI=1/C29H46O3/c1-18(2)8-7-9-19(3)21-11-12-22-20-10-13-24-28(5,23(20)14-16-27(21,22)4)17-15-25(30)29(24,6)26(31)32/h8,19,21-22,24-25,30H,7,9-17H2,1-6H3,(H,31,32)/t19-,21?,22?,24?,25-,27+,28+,29-/m0/s1
name: 4-Methylzymosterol intermediate 1
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
has only substance units: false
boundary condition: false
is: HMDB06927

http://identifiers.org/biomodels.db/MODEL1310110022#_85a3bc2c_d18f_4e9a_8cab_7e325101290b
type: Species
is: SBO:0000252
is encoded by: hsa:8854
boundary condition: true
initial concentration: NaN
is: B4DZR2
has only substance units: false
constant: false
name: ALDH1A2
initial amount: NaN

metaR r2380
is described by: ECO:0000000
type: Reaction
product: MODEL1310110022#
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false

metaR r2508
fast: false
kinetic law: MODEL1310110022#
reversible: true
is: SBO:0000185
name: Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reactant: MODEL1310110022#
type: Reaction
product: MODEL1310110022#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110022#_f61673bd_c50f_48eb_af86_14b81e8c09b6
constant: false
is: SBO:0000252
is encoded by: hsa:1103
initial amount: NaN
type: Species
initial concentration: NaN
name: CHAT
is: Q6LEN6
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110022#_a4e132f3_f8a6_4f64_9b2d_f8dd356e630f
name: PPCS
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: Q9HAB8
type: Species
is encoded by: hsa:79717

http://identifiers.org/biomodels.db/MODEL1310110022#_75177729_ac49_4fee_9bdf_0a70093fcd5c
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
has only substance units: false
name: HMGCS2
is encoded by: hsa:3158
initial concentration: NaN
boundary condition: true
is: P54868

metaM sphs1p c
boundary condition: false
constant: false
is: HMDB00277
is: CHEBI:60119
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
is: SBO:0000247
name: sphingosine 1-phosphate(1-)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_97215376_f3a5_4502_8807_bba3efb77e14
constant: false
initial amount: NaN
name: ACP2
is encoded by: hsa:53
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is: E9PCI1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110022#_2bf80c0a_3f53_40da_8196_5008e24720ce
has only substance units: false
initial amount: NaN
constant: false
name: SLC24A3
is encoded by: hsa:57419
is: Q9HC58
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species

metaM 4mop e
name: 4-methyl-2-oxopentanoate
initial concentration: 1.0
is: SBO:0000247
is: HMDB00695
is: CHEBI:17865
boundary condition: false
has only substance units: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
type: Species
constant: false
initial amount: NaN

metaM acgam1p c
constant: false
initial amount: NaN
name: N-Acetyl-D-glucosamine 1-phosphate
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01256 EHMN_ABBREVIATION: C04256
is: SBO:0000247
is: HMDB01367
has only substance units: false
is: CHEBI:7125

metaR FAOXOHC22C22DCc
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(w-OHC22-->C22DC)c
type: Reaction

metaR r1926
name: Y+LAT2 Utilized transport
reactant: MODEL1310110022#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110022#
reversible: false
is: SBO:0000185
product: MODEL1310110022#
type: Reaction
fast: false
modifier: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_4f3a2fc3_0665_437a_a24d_fb13d7b7d957
has only substance units: false
is: SBO:0000252
name: FAH
is: P16930
initial amount: NaN
is encoded by: hsa:2184
type: Species
boundary condition: true
initial concentration: NaN
constant: false

metaR r2507
product: MODEL1310110022#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
kinetic law: MODEL1310110022#
name: Utilized transport
reactant: MODEL1310110022#
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaM ha e
initial concentration: 1.0
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
initial amount: NaN
is: CHEBI:16336
boundary condition: false
type: Species
constant: false
is: SBO:0000247
has only substance units: false
name: hyaluronan

metaR r0390
fast: false
reactant: MODEL1310110022#
type: Reaction
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
product: MODEL1310110022#
is described by: ECO:0000000
kinetic law: MODEL1310110022#

metaR NACHEX14ly
reversible: false
reactant: MODEL1310110022#
type: Reaction
modifier: MODEL1310110022#
is: SBO:0000176
kinetic law: MODEL1310110022#
is described by: ECO:0000000
fast: false
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

metaR RE2660C
product: MODEL1310110022#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110022#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
name: RE2660
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110022#

metaM r1p c
constant: false
initial concentration: 1.0
is: HMDB01489
is: SBO:0000247
has only substance units: false
type: Species
name: alpha-D-Ribose 1-phosphate
is: CHEBI:57720
is: C00442
boundary condition: false
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_b6def372_6110_4bbc_9465_c3abf22db78c
type: Species
initial concentration: NaN
is: SBO:0000252
is: A0S0A7
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:4846
name: NOS3
constant: false

metaR DSAT
product: MODEL1310110022#
kinetic law: MODEL1310110022#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ
reactant: MODEL1310110022#
fast: false
reversible: false
is described by: ECO:0000000
name: dihydrosphingosine N-acyltransferase

metaM trdox m
has only substance units: false
type: Species
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
boundary condition: false
is: SBO:0000247
is: CHEBI:18191
initial concentration: 1.0
constant: false
initial amount: NaN
name: Oxidized thioredoxin

http://identifiers.org/biomodels.db/MODEL1310110022#_eb1c0b7b_531b_4467_aca9_45aeb4b073aa
boundary condition: true
type: Species
is: E7ET30
name: AK3
is encoded by: hsa:50808
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN

metaR PNTK
fast: false
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (79646.1) or (80025.2) or (53354.1) or (53354.3) or (80025.1) or (53354.2) or (80025.3) or (80025.4) or (55229.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110022#
is: SBO:0000176
name: pantothenate kinase
is version of: http://identifiers.org/ec-code/2.7.1.33
kinetic law: MODEL1310110022#
reversible: false
is described by: ECO:0000269
type: Reaction
product: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_f12c9b88_f54c_44d0_ac77_d8e2d1b5eb88
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1962
name: EHHADH
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is: Q9NY65

metaR r1649
is: SBO:0000185
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110022#
reactant: MODEL1310110022#
fast: false
product: MODEL1310110022#
kinetic law: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110022#_ebe44c37_d362_42f7_a00b_369a8a7fa673
type: Species
initial amount: NaN
is encoded by: hsa:4697
boundary condition: true
is: O00483
initial concentration: NaN
name: NDUFA4
has only substance units: false
is: SBO:0000252
constant: false

metaR HMGCOAtm
fast: false
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:NCD
name: Hydroxymethylglutaryl-CoA reversible mitochondrial transport
kinetic law: MODEL1310110022#
product: MODEL1310110022#
is: SBO:0000185
reactant: MODEL1310110022#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_f053a810_e626_41cf_a09d_7bafb7e1f1a9
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:53919
name: SLCO1C1
type: Species
initial concentration: NaN
boundary condition: true
is: Q5JPA4

metaM dutp n
initial concentration: 1.0
boundary condition: false
is: HMDB01191
has only substance units: false
name: dUTP
is: CHEBI:17625
is: SBO:0000247
constant: false
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_8faeccd3_07c2_47fe_89d8_57edad69ecf4
is encoded by: hsa:4728
has only substance units: false
is: O00217
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
name: NDUFS8

metaR r2506
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
kinetic law: MODEL1310110022#
name: Utilized transport
reactant: MODEL1310110022#
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110022#

metaR r2040
kinetic law: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
modifier: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110022#
fast: false
type: Reaction

metaR r0391
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 2.4.2.11 Confidence Level: 0 AUTHORS: PMID:17604275 NOTES:
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110022#
type: Reaction
name: Nicotinate D-ribonucleotide:pyrophosphate phosphoribosyltransferase Nicotinate and nicotinamide metabolism EC:2.4.2.11
kinetic law: MODEL1310110022#
is: SBO:0000176
product: MODEL1310110022#

metaM ptth m
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
is: HMDB03426
initial amount: NaN
constant: false
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
name: pantetheine
is: CHEBI:16753
initial concentration: 1.0

metaR SO4t4 2
fast: false
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110022#
name: sulfate transport via sodium symport
product: MODEL1310110022#
modifier: MODEL1310110022#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
kinetic law: MODEL1310110022#

metaR RTOTALt
kinetic law: MODEL1310110022#
is: SBO:0000185
name: RTOTAL transport
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110022#
product: MODEL1310110022#

metaR r2382
kinetic law: MODEL1310110022#
product: MODEL1310110022#
modifier: MODEL1310110022#
fast: false
is: SBO:0000185
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
type: Reaction

metaR EX dgsn LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyguanosine
type: Reaction

metaR O2tn
type: Reaction
fast: false
name: O2 nuclear transport
kinetic law: MODEL1310110022#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
product: MODEL1310110022#
reversible: true
reactant: MODEL1310110022#

metaR r0393
is described by: ECO:0000000
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
kinetic law: MODEL1310110022#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.74
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
type: Reaction
reversible: false
reactant: MODEL1310110022#
is: SBO:0000176
modifier: MODEL1310110022#

metaM frdp c
is: C00448
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:175763
name: Farnesyl diphosphate
boundary condition: false
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
initial concentration: 1.0
is: HMDB00961
constant: false
initial amount: NaN

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

metaM trdrd c
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
is: C00342
name: Reduced thioredoxin
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:15967
type: Species
initial concentration: 1.0

metaM mn l
has only substance units: false
name: beta-1,4-mannose-N-acetylglucosamine
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1
is: HMDB06535

http://identifiers.org/biomodels.db/MODEL1310110022#_9255e79b_b4a5_43ec_8420_43987c607dbf
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
constant: false
has only substance units: false
name: _AI924226_1_m
is: SBO:0000252
is encoded by: hsa:AI924226

metaR O2t
reversible: true
reactant: MODEL1310110022#
is: SBO:0000185
name: o2 transport (diffusion)
kinetic law: MODEL1310110022#
product: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
is described by: ECO:0000000
type: Reaction

metaM fad c
is: C00016
initial concentration: 1.0
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
name: Flavin adenine dinucleotide oxidized
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:16238
type: Species
has only substance units: false
boundary condition: false
is: HMDB01248

http://identifiers.org/biomodels.db/MODEL1310110022#_09d9be74_a7da_450c_84d8_e79f0732c297
name: HAO2
is: SBO:0000252
type: Species
has only substance units: false
is: Q9NYQ3
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:51179

metaR ACGAMK
is: SBO:0000176
fast: false
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.59 Confidence Level: 4 AUTHORS: PMID:10824116 NOTES:
modifier: MODEL1310110022#
name: N-acetylglucosamine kinase
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.7.1.59
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110022#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110022#_7ca7b956_47da_42ec_b219_7d448eb7e597
is encoded by: hsa:1371
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
name: CPOX
is: P36551

metaR GALASE5ly
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
name: beta-galactosidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110022#
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
reversible: false
reactant: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_4dd5dd56_9c76_4ba3_a8fd_ac5b67669694
name: GCSH
is: P23434
is encoded by: hsa:2653
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN

metaR CAATPS
notes: GENE_ASSOCIATION: (492.1) or (491.1) or (490.1) or (493.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.6 Confidence Level: 4 AUTHORS: PMID:7876199,PMID:8396145 NOTES:plasma membrane version (SR and ER versions also exist) stoichiometry actually varies (number of Ca/ATP transported). See PMID: 7876199 NJ
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
reversible: false
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.3.8
name: Ca ATPase
product: MODEL1310110022#
modifier: MODEL1310110022#
fast: false
is: SBO:0000185

metaR PCHOLP hs
is described by: ECO:0000269
type: Reaction
name: choline phosphatase
reversible: false
modifier: MODEL1310110022#
product: MODEL1310110022#
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.4
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:9395408,PMID:9582313 NOTES:NJ
fast: false

metaR PCm
is described by: ECO:0000269
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (5091.1) or (5091.2) SUBSYSTEM: Pyruvate metabolism EC Number: 6.4.1.1 Confidence Level: 4 AUTHORS: PMID:6548474 NOTES:TV Metabolism at a glance
modifier: MODEL1310110022#
name: pyruvate carboxylase
is version of: http://identifiers.org/ec-code/6.4.1.1
is: SBO:0000176
fast: false
product: MODEL1310110022#
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

metaR r0614
is described by: ECO:0000000
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
type: Reaction
reactant: MODEL1310110022#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
fast: false
reversible: true
product: MODEL1310110022#
kinetic law: MODEL1310110022#

metaM lys L c
initial amount: NaN
name: L-lysinium(1+)
is: HMDB00182
is: CHEBI:32551
is: SBO:0000247
boundary condition: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
constant: false
initial concentration: 1.0
type: Species
has only substance units: false

metaR O2tm
product: MODEL1310110022#
is described by: ECO:0000000
name: O2 transport (diffusion)
kinetic law: MODEL1310110022#
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
reactant: MODEL1310110022#
is: SBO:0000185

metaR r0392
is described by: ECO:0000000
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
reactant: MODEL1310110022#
product: MODEL1310110022#
kinetic law: MODEL1310110022#
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110022#_308b7b16_30e2_4c6a_a9ba_bb4166656878
boundary condition: true
name: GUK1
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is: Q16774
is: SBO:0000252
is encoded by: hsa:2987
constant: false

metaM ksi deg17 l
is: SBO:0000247
is: CHEBI:12936
constant: false
is: HMDB00143
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C152H245N10O132S7 CHARGE: -7
name: keratan sulfate I, degradation product 17

metaR EX ptrc LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 1,4-butanediammonium
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_27ccc981_951e_44f6_a727_f399085ad606
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:58510
type: Species
is: Q9UF12
has only substance units: false
initial concentration: NaN
name: PRODH2

metaM na1 c
initial amount: NaN
name: Sodium
constant: false
is: CHEBI:4541
type: Species
has only substance units: false
notes: FORMULA: Na CHARGE: 1
is: HMDB00588
initial concentration: 1.0
is: C01330
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110022#_d85838fa_c5c7_4978_b615_e94dc1f8583a
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:AA081045
name: _AA081045_1_m
type: Species
is: SBO:0000252

metaR FADDPle
kinetic law: MODEL1310110022#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5167.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
reactant: MODEL1310110022#
fast: false
name: FAD diphosphatase
is version of: http://identifiers.org/ec-code/3.1.4.1
reversible: false
type: Reaction
product: MODEL1310110022#
modifier: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_52e247b8_0338_439e_8d77_2961febe8bf1
is encoded by: hsa:6576
constant: false
name: SLC25A1
is: D9HTE9
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaR SERGLNexR
reversible: true
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
kinetic law: MODEL1310110022#
type: Reaction
reactant: MODEL1310110022#
name: L-Serine/Glutamine reversible exchange
modifier: MODEL1310110022#
fast: false
product: MODEL1310110022#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110022#_f80f28e7_6f3c_4e01_947c_4fa17ee3db09
is encoded by: hsa:6390
has part: O14521
type: Species
initial concentration: NaN
name: SDHA:SDHB:SDHC:SDHD
is encoded by: hsa:6392
has part: P31040
has part: Q99643
is: SBO:0000297
has only substance units: false
boundary condition: true
is encoded by: hsa:6389
initial amount: NaN
constant: false
is encoded by: hsa:6391
has part: P21912

metaM ile L c
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
boundary condition: false
has only substance units: false
is: CHEBI:17191
name: L-isoleucine
is: HMDB00172
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110022#_f621be87_df5d_482a_b455_5dd65a03d285
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AL048840
name: _AL048840_1_c

metaR RE1898C
name: RE1898
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
type: Reaction
reactant: MODEL1310110022#
fast: false
product: MODEL1310110022#
reversible: true
is: SBO:0000176
is described by: ECO:0000000

metaR r1924
modifier: MODEL1310110022#
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
fast: false
product: MODEL1310110022#
is described by: ECO:0000000
is: SBO:0000185
name: Y+LAT2 Utilized transport
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM gln L c
constant: false
name: L-glutamine
initial amount: NaN
is: CHEBI:18050
initial concentration: 1.0
is: HMDB00641
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false

metaM bhb c
initial amount: NaN
is: CHEBI:10983
constant: false
name: (R)-3-hydroxybutyrate
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
type: Species
boundary condition: false
is: HMDB00011

http://identifiers.org/biomodels.db/MODEL1310110022#_192a5dfc_8245_4283_8f68_2e96e098e2a5
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: _AI024818_1_c
is encoded by: hsa:AI024818
constant: false
type: Species
initial concentration: NaN
boundary condition: true

metaR G6PDH2rer
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:NCD
product: MODEL1310110022#
is: SBO:0000176
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum
fast: false
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110022#
modifier: MODEL1310110022#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.47
kinetic law: MODEL1310110022#

metaM fad e
is: SBO:0000247
type: Species
is: HMDB01248
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: C00016
name: Flavin adenine dinucleotide oxidized
has only substance units: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: CHEBI:16238
constant: false

metaR r0407
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
reversible: true
is: SBO:0000176
product: MODEL1310110022#
kinetic law: MODEL1310110022#
type: Reaction
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.4.3.5
fast: false
reactant: MODEL1310110022#

metaM apoC Lys c
name: Apocarboxylase (Lys residue)
constant: false
is: CHEBI:32551
has only substance units: false
notes: FORMULA: C6H13N2OX CHARGE: 0
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB00182
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_888a3e32_101a_4b57_b52c_873e18174fe9
has only substance units: false
type: Species
is: SBO:0000252
name: COX7B2
initial amount: NaN
is: Q8TF08
initial concentration: NaN
is encoded by: hsa:170712
constant: false
boundary condition: true

metaR GTHRDtr
is: SBO:0000185
name: glutathione transport via diffusion
is described by: ECO:0000000
product: MODEL1310110022#
reversible: true
fast: false
kinetic law: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - NJ
reactant: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_85cca38e_6fa1_450f_8b4c_f8cfab34c6ef
has only substance units: false
name: PANK1
is encoded by: hsa:53354
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_35b0fed5_8b32_499f_ba52_f23298ae4c54
boundary condition: true
name: ACADL
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:33
constant: false
is: P28330

metaR TCYNTtm
name: Thiocyanate transport via diffusion (mitochondrial)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
fast: false
reversible: false
reactant: MODEL1310110022#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110022#
is described by: ECO:0000000
product: MODEL1310110022#

metaR r1650
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
is: SBO:0000185
reversible: true
product: MODEL1310110022#
modifier: MODEL1310110022#
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR RE1691M
is: SBO:0000176
name: RE1691
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (7263.1) SUBSYSTEM: Miscellaneous EC Number: 2.8.1.1 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:9070219 NOTES:
product: MODEL1310110022#
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.8.1.1
reversible: true
fast: false
reactant: MODEL1310110022#
type: Reaction
is described by: ECO:0000000

metaR r0394
reversible: true
reactant: MODEL1310110022#
type: Reaction
product: MODEL1310110022#
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
kinetic law: MODEL1310110022#
fast: false
is: SBO:0000176
is described by: ECO:0000000

metaM xan c
is: CHEBI:17712
is: HMDB00292
name: Xanthine
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
initial concentration: 1.0
is: SBO:0000247
is: C00385
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_3772b68f_4d43_4ce1_b6f6_223682657b78
is: B3KTV4
has only substance units: false
type: Species
name: ADSSL1
initial concentration: NaN
is encoded by: hsa:122622
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaM orot c
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:30839
initial concentration: 1.0
type: Species
name: Orotate
initial amount: NaN
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
boundary condition: false
is: HMDB00226
is: C00295

metaR r0051
modifier: MODEL1310110022#
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
reversible: true
is: SBO:0000176
product: MODEL1310110022#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
reactant: MODEL1310110022#
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.5
type: Reaction
kinetic law: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_d6d1019d_9e0f_4077_b593_e3a3561b0df3
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is: O00476
initial amount: NaN
name: SLC17A3
boundary condition: true
is encoded by: hsa:10786

metaR r0973
name: Facilitated diffusion
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
reversible: true
product: MODEL1310110022#
fast: false
kinetic law: MODEL1310110022#

metaM bhb e
boundary condition: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
name: (R)-3-hydroxybutyrate
initial concentration: 1.0
constant: false
is: HMDB00011
is: CHEBI:10983
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species

metaR r0408
type: Reaction
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.4.3.5
product: MODEL1310110022#
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
reversible: true
reactant: MODEL1310110022#
fast: false
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
is: SBO:0000176

metaR LYStm
kinetic law: MODEL1310110022#
product: MODEL1310110022#
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
name: Lysine mitochondrial transport via ornithine carrier
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
reactant: MODEL1310110022#
fast: false
reversible: true
modifier: MODEL1310110022#

metaM gln L e
initial amount: NaN
is: CHEBI:18050
has only substance units: false
name: L-glutamine
is: HMDB00641
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
type: Species
constant: false
boundary condition: false

metaM hs deg13 l
type: Species
notes: FORMULA: C55H83N3O61S5 CHARGE: -6
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01352
is: CHEBI:17180
is: SBO:0000247
has only substance units: false
boundary condition: false
name: heparan sulfate, degradation product 13

metaM ksi deg8 l
notes: FORMULA: C194H311N13O171S10 CHARGE: -10
is: SBO:0000247
is: HMDB00143
is: CHEBI:12936
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
name: keratan sulfate I, degradation product 8

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

metaR r2512
type: Reaction
is described by: ECO:0000000
fast: false
name: Utilized transport
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reactant: MODEL1310110022#
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110022#

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

metaR EX 4mop LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-methyl-2-oxopentanoate
type: Reaction

metaR r1651
fast: false
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110022#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110022#
type: Reaction
reactant: MODEL1310110022#

metaR r2388
product: MODEL1310110022#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
modifier: MODEL1310110022#
reactant: MODEL1310110022#
reversible: false
kinetic law: MODEL1310110022#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction

metaM ksi deg36 l
type: Species
is: SBO:0000247
constant: false
is: CHEBI:12936
initial concentration: 1.0
is: HMDB00143
initial amount: NaN
boundary condition: false
notes: FORMULA: C62H103N4O49S1 CHARGE: -1
has only substance units: false
name: keratan sulfate I, degradation product 36

metaR BACCL
reactant: MODEL1310110022#
name: biotin-[acetyl-CoA-carboxylase] ligase
modifier: MODEL1310110022#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
is version of: http://identifiers.org/ec-code/6.3.4.10
is described by: ECO:0000269
product: MODEL1310110022#
fast: false
reversible: false
kinetic law: MODEL1310110022#
type: Reaction

metaR r0618
reactant: MODEL1310110022#
product: MODEL1310110022#
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
reversible: true
kinetic law: MODEL1310110022#
is: SBO:0000176
is described by: ECO:0000000

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

metaM Rtotal2 e
type: Species
boundary condition: false
name: R total 2 position
is: SBO:0000247
notes: FORMULA: CO2FULLR2 CHARGE: -1
initial amount: NaN
has only substance units: false
is: CHEBI:16988
constant: false
is: HMDB00283
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110022#_a9c79b9c_9961_4c58_b32c_b6e80eb59dc4
name: SLC6A7
initial concentration: NaN
constant: false
is: Q99884
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:6534

metaM malttr e
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
is: CHEBI:27931
constant: false
is: HMDB01262
initial amount: NaN
has only substance units: false
name: maltotriose
initial concentration: 1.0
is: C01835
is: SBO:0000247
boundary condition: false
type: Species

metaR r0170
kinetic law: MODEL1310110022#
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.7.1.40
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
type: Reaction
reversible: true
product: MODEL1310110022#
is described by: ECO:0000000
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110022#_e1028dd1_b42d_4a86_aa16_cc9b6d44509d
initial concentration: NaN
is: Q13630
is: SBO:0000252
is encoded by: hsa:7264
name: TSTA3
initial amount: NaN
has only substance units: false
type: Species
constant: false
boundary condition: true

metaM pchol hs r
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
name: Phosphatidylcholine
constant: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
is: CHEBI:16110

metaM 3pg c
constant: false
is: http://identifiers.org/pubchem.compound/3497
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB00807
has only substance units: false
initial concentration: 1.0
is: CHEBI:58272
name: 3-Phospho-D-glycerate
is: C00197

http://identifiers.org/biomodels.db/MODEL1310110022#_e71c899b_64cc_4386_aab2_267ed152bcf2
is: Q16739
initial amount: NaN
boundary condition: true
is encoded by: hsa:7357
name: UGCG
has only substance units: false
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN

metaR r2389
fast: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110022#
product: MODEL1310110022#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110022#
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110022#

metaM 4abut c
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
is: HMDB00112
name: 4-Aminobutanoate
notes: FORMULA: C4H9NO2 CHARGE: 0
is: C00334
is: CHEBI:3628
constant: false

metaR r1652
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
modifier: MODEL1310110022#
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110022#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_82a10197_e3c0_48ed_b5da_0d3876044296
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:84569
constant: false
boundary condition: true
initial concentration: NaN
is: Q6UWQ5
name: LYZL1
has only substance units: false
type: Species

metaM fum c
is: C00122
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: Fumarate
is: HMDB00134
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
has only substance units: false
initial amount: NaN
is: CHEBI:29806

metaR RE2799C
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
product: MODEL1310110022#
type: Reaction
kinetic law: MODEL1310110022#
reversible: true
is described by: ECO:0000000
fast: false
reactant: MODEL1310110022#
is: SBO:0000176
name: RE2799

http://identifiers.org/biomodels.db/MODEL1310110022#_0d667835_1542_4f47_ab33_64dd2d78e0e8
name: _C7orf24_1_m
boundary condition: true
type: Species
is encoded by: hsa:C7orf24
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaM leuktrC4 e
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB01198
constant: false
initial amount: NaN
is: CHEBI:57973
is: SBO:0000247
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
name: leukotriene C4(2-)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_081a4084_c27e_4e34_9619_d9851c0ca3c8
is encoded by: hsa:10935
initial amount: NaN
boundary condition: true
name: PRDX3
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is: P30048

metaM trdox c
has only substance units: false
boundary condition: false
name: Oxidized thioredoxin
type: Species
constant: false
is: SBO:0000247
is: CHEBI:18191
initial concentration: 1.0
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
is: C00343
initial amount: NaN

metaR RE3273C
is described by: ECO:0000000
reactant: MODEL1310110022#
product: MODEL1310110022#
fast: false
kinetic law: MODEL1310110022#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.4
name: RE3273
reversible: true
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:3135804 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_083ee75b_6c3b_412c_bb1b_0f0d41956203
type: Species
boundary condition: true
is: P00918
initial concentration: NaN
has only substance units: false
constant: false
name: CA2
initial amount: NaN
is encoded by: hsa:760
is: SBO:0000252

metaM ksi deg20 l
notes: FORMULA: C138H223N9O119S6 CHARGE: -6
is: HMDB00143
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:12936
has only substance units: false
constant: false
name: keratan sulfate I, degradation product 20
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110022#_9de9d022_b42f_4cdf_b27e_869db6b7797a
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5162
is encoded by: hsa:5161
boundary condition: true
type: Species
has part: P11177
has part: P29803
constant: false
is: SBO:0000297
initial amount: NaN
name: DLAT:DLD:PDHA2:PDHB:PDHX
has part: Q86YI5
is encoded by: hsa:1737

metaM 56dthm m
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
is: CHEBI:27468
boundary condition: false
has only substance units: false
name: 5,6-dihydrothymine
is: HMDB00079

metaR MALtm
product: MODEL1310110022#
name: malate transport, mitochondrial
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:IF
modifier: MODEL1310110022#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110022#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_637c96ef_0bff_470c_874c_9ea89c555e02
name: _AI971036_1_c
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:AI971036
is: SBO:0000252
type: Species

metaM r5p c
is: C00117
initial concentration: 1.0
boundary condition: false
is: HMDB00618
is: CHEBI:18189
has only substance units: false
type: Species
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
name: alpha-D-Ribose 5-phosphate
initial amount: NaN
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110022#_73039178_348f_4113_bc68_f014f6a7c6f2
is encoded by: hsa:AV717590
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
name: _AV717590_1_c

metaR O2tp
reactant: MODEL1310110022#
type: Reaction
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
name: O2 transport, peroxisomal
is: SBO:0000185
reversible: true
product: MODEL1310110022#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110022#_0e0b2e3d_a7e1_49a0_91a6_df50f8f9cc91
is: SBO:0000252
constant: false
is encoded by: hsa:158
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
name: ADSL

metaM lys L e
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: L-lysinium(1+)
is: HMDB00182
is: CHEBI:32551
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
boundary condition: false

metaR r1653
reversible: true
reactant: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110022#
product: MODEL1310110022#
fast: false
modifier: MODEL1310110022#

metaR SBT Dtde
type: Reaction
is: SBO:0000185
reactant: MODEL1310110022#
name: D-sorbitol transport, extracellular
reversible: true
is described by: ECO:0000134
product: MODEL1310110022#
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
fast: false

metaM 34dhmald c
type: Species
constant: false
has only substance units: false
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
is: C05577
is: HMDB06242
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: 3,4-Dihydroxymandelaldehyde
is: http://identifiers.org/pubchem.compound/7903

metaR r0399
type: Reaction
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
fast: false
is version of: http://identifiers.org/ec-code/1.2.4.2
modifier: MODEL1310110022#
reversible: true
reactant: MODEL1310110022#
is: SBO:0000176
kinetic law: MODEL1310110022#
product: MODEL1310110022#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:

metaR XYLt
modifier: MODEL1310110022#
fast: false
reversible: true
name: D-xylose reversible transport
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110022#
product: MODEL1310110022#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110022#

metaR r0616
is described by: ECO:0000000
product: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
fast: false
kinetic law: MODEL1310110022#
reversible: true
type: Reaction
modifier: MODEL1310110022#
is: SBO:0000176
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

metaM 4mop m
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
name: 4-methyl-2-oxopentanoate
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
type: Species
is: HMDB00695
is: CHEBI:17865
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_6266587e_8213_4d16_a23a_b5e6b3fe3c5b
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is encoded by: hsa:954
is: Q5SPY7
is: SBO:0000252
name: ENTPD2
has only substance units: false

metaR r1654
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110022#
product: MODEL1310110022#

metaM leuktrC4 c
initial concentration: 1.0
is: CHEBI:57973
is: SBO:0000247
has only substance units: false
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
boundary condition: false
type: Species
initial amount: NaN
is: HMDB01198
constant: false
name: leukotriene C4(2-)

http://identifiers.org/biomodels.db/MODEL1310110022#_84ba6b17_4082_40ce_9d93_9d2d91c73924
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is: B4DIA3
is: SBO:0000252
boundary condition: true
name: SLC6A8
is encoded by: hsa:6535

http://identifiers.org/biomodels.db/MODEL1310110022#_5ff5777f_be7d_49f6_bc54_61613fdf9d28
initial amount: NaN
is encoded by: hsa:8310
is: SBO:0000252
has only substance units: false
name: ACOX3
boundary condition: true
initial concentration: NaN
type: Species
is: O15254
constant: false

metaR PMEVKc
is version of: http://identifiers.org/ec-code/2.7.4.2
fast: false
reactant: MODEL1310110022#
name: phosphomevalonate kinase, cytosol
type: Reaction
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (10654.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added to substrate for elemental balancing.
modifier: MODEL1310110022#
product: MODEL1310110022#
is described by: ECO:0000134
kinetic law: MODEL1310110022#

metaM andrstandn r
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:15994
is: HMDB00899
has only substance units: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
initial amount: NaN
type: Species
name: 5alpha-androstane-3,17-dione

metaM HC01223 m
boundary condition: false
constant: false
initial concentration: 1.0
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
initial amount: NaN
is: CHEBI:57340
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047

http://identifiers.org/biomodels.db/MODEL1310110022#_97ad91e6_7c01_41b3_afa6_8bc0a1183941
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaR GLUt7l
kinetic law: MODEL1310110022#
fast: false
type: Reaction
is described by: ECO:0000000
reversible: false
name: Glutamate transport, lysosomal
is: SBO:0000185
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
product: MODEL1310110022#

metaR r1756
reversible: false
name: Y+LAT2 Utilized transport
modifier: MODEL1310110022#
is: SBO:0000185
kinetic law: MODEL1310110022#
type: Reaction
reactant: MODEL1310110022#
product: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110022#_06c7cfe5_42f4_4334_803f_86a17f1a3836
initial amount: NaN
name: DGKZ
constant: false
is: B7Z6M3
type: Species
is encoded by: hsa:8525
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110022#_baf8ce94_aafb_4a3e_bd32_83e5810de13d
is: Q96C36
is: SBO:0000252
name: PYCR2
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:29920

metaM so3 m
has only substance units: false
is: CHEBI:17137
is: SBO:0000247
type: Species
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
is: HMDB00240
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
name: hydrogensulfite

metaR ACHtn
is: SBO:0000185
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reversible: true
reactant: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
is described by: ECO:0000000
name: Acetylcholin transport, nuclear trhough pores
fast: false

http://identifiers.org/biomodels.db/MODEL1310110022#_fc4d5248_97a9_46b1_a8eb_38a21e7b954f
is: P22413
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
constant: false
is encoded by: hsa:5167
name: ENPP1
initial concentration: NaN

metaM bhb m
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
name: (R)-3-hydroxybutyrate
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:10983
is: HMDB00011
has only substance units: false

metaR ABTD
reversible: true
product: MODEL1310110022#
is described by: ECO:0000000
reactant: MODEL1310110022#
fast: false
kinetic law: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
is: SBO:0000176
name: L-arabinitol 4-dehydrogenase

metaM mercplaccys e
type: Species
boundary condition: false
name: 3-mercaptolactate-cysteine disulfide
is: SBO:0000247
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
is: HMDB06512
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false

metaM leuktrC4 r
is: HMDB01198
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
name: leukotriene C4(2-)
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:57973
is: SBO:0000247

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

metaM betald m
constant: false
is: HMDB01252
type: Species
initial amount: NaN
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
has only substance units: false
boundary condition: false
name: betaine aldehyde
initial concentration: 1.0
is: CHEBI:15710
is: SBO:0000247

metaM leuktrD4 e
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
type: Species
constant: false
boundary condition: false
is: CHEBI:28666
initial amount: NaN
is: SBO:0000247
name: Leukotriene D4
is: HMDB03080

metaM cbasp c
is: SBO:0000247
is: HMDB00828
type: Species
has only substance units: false
is: CHEBI:32814
name: N-Carbamoyl-L-aspartate
is: C00438
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C5H6N2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00356 EHMN_ABBREVIATION: C00438
initial amount: NaN

metaR 3MOPte
fast: false
product: MODEL1310110022#
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of 3-methyl-2-oxopentanoate
reversible: true
is: SBO:0000185

metaM prostgf2 c
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
type: Species
initial amount: NaN
constant: false
is: CHEBI:57404
boundary condition: false
has only substance units: false
name: prostaglandin F2alpha(1-)
is: HMDB01139
initial concentration: 1.0
is: SBO:0000247

metaR RE2079R
type: Reaction
reversible: true
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
is: SBO:0000176
name: RE2079
kinetic law: MODEL1310110022#
product: MODEL1310110022#
fast: false
is described by: ECO:0000000

metaR GALASE12ly
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
product: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
name: beta-galactosidase, lysosomal
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110022#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_1746cc0d_7040_4ae5_b635_e25f526b9282
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:AL050025
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
name: _AL050025_1_c

metaR MI145PK
kinetic law: MODEL1310110022#
product: MODEL1310110022#
modifier: MODEL1310110022#
is described by: ECO:0000269
reactant: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
name: inositol-1,4,5-trisphosphate 3-kinase
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.127
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110022#_737be613_69d3_4fb5_8422_606b8d887df3
constant: false
name: CTPS1
is encoded by: hsa:1503
initial amount: NaN
type: Species
is: P17812
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR r1433
is described by: ECO:0000000
reactant: MODEL1310110022#
product: MODEL1310110022#
kinetic law: MODEL1310110022#
is: SBO:0000176
name: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
type: Reaction

metaR GALU
fast: false
type: Reaction
product: MODEL1310110022#
kinetic law: MODEL1310110022#
is: SBO:0000176
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.7.7.9
is described by: ECO:0000134
reactant: MODEL1310110022#
name: UTP-glucose-1-phosphate uridylyltransferase
reversible: true
notes: GENE_ASSOCIATION: (7360.1) or (7359.1) or (7360.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.9 Confidence Level: 0 AUTHORS: PMID:9119383 NOTES:Human Y/N: Y

http://identifiers.org/biomodels.db/MODEL1310110022#_70f4608f_5e68_4fb3_ac6e_202d9b5c79f8
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:89869
type: Species
name: PLCZ1
initial concentration: NaN
has only substance units: false
is: Q86YW0
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110022#_97c30a71_7ca7_44c0_926e_63ac08d7c795
name: PLCD4
is encoded by: hsa:84812
is: Q9BRC7
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
type: Species
boundary condition: true
initial amount: NaN

metaM pan4p c
is: CHEBI:47942
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
is: HMDB01416
has only substance units: false
initial amount: NaN
type: Species
is: C01134
name: Pantetheine 4'-phosphate
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_b1a18c65_9fcf_4c6e_99aa_3a137f8ba928
constant: false
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:D87002
name: _D87002_1_e

metaR r1544
product: MODEL1310110022#
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110022#

metaM dcyt c
is: CHEBI:15698
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
is: C00881
name: Deoxycytidine
is: HMDB00014
is: SBO:0000247
constant: false
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
initial concentration: 1.0

metaR r0552
kinetic law: MODEL1310110022#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
reactant: MODEL1310110022#
product: MODEL1310110022#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.5.1
modifier: MODEL1310110022#
fast: false
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
reversible: true

metaR VALTA
product: MODEL1310110022#
fast: false
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.6.1.42
reactant: MODEL1310110022#
modifier: MODEL1310110022#
is: SBO:0000176
reversible: true
name: valine transaminase
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:

metaR 2MCITt
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:426765 NOTES:MM
type: Reaction
kinetic law: MODEL1310110022#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110022#
fast: false
name: 2-methylcitrate transport via diffusion
product: MODEL1310110022#

metaM fad m
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: C00016
name: Flavin adenine dinucleotide oxidized
has only substance units: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: CHEBI:16238
constant: false
type: Species
boundary condition: false
is: HMDB01248

metaM mercplaccys c
name: 3-mercaptolactate-cysteine disulfide
boundary condition: false
type: Species
constant: false
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
has only substance units: false
is: SBO:0000247
is: HMDB06512
initial concentration: 1.0
initial amount: NaN

metaR r1434
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110022#
product: MODEL1310110022#
type: Reaction
kinetic law: MODEL1310110022#
is: SBO:0000185
name: Transport reaction
is described by: ECO:0000000
reversible: false

metaM mi1p D c
constant: false
type: Species
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
is: SBO:0000247
name: 1D-myo-inositol 1-phosphate(2-)
initial amount: NaN
is: CHEBI:58433
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB02985

metaM gln L m
is: HMDB00641
initial concentration: 1.0
boundary condition: false
is: CHEBI:18050
name: L-glutamine
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067

metaM prostgf2 e
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
is: CHEBI:57404
boundary condition: false
has only substance units: false
is: HMDB01139
is: SBO:0000247
name: prostaglandin F2alpha(1-)
initial concentration: 1.0

metaM his L m
is: SBO:0000247
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
has only substance units: false
name: L-histidine
initial amount: NaN
type: Species
is: CHEBI:15971
is: HMDB00177
initial concentration: 1.0
boundary condition: false
constant: false

metaR NNATr
fast: false
modifier: MODEL1310110022#
is: SBO:0000176
notes: GENE_ASSOCIATION: (349565.1) or (23057.2) or (23057.1) SUBSYSTEM: NAD metabolism EC Number: 2.7.7.18 Confidence Level: 4 AUTHORS: PMID:12574164,PMID:14516279 NOTES:JLR
is version of: http://identifiers.org/ec-code/2.7.7.1
product: MODEL1310110022#
name: nicotinate-nucleotide adenylyltransferase
reactant: MODEL1310110022#
reversible: true
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110022#

metaM 4abut e
name: 4-Aminobutanoate
notes: FORMULA: C4H9NO2 CHARGE: 0
is: CHEBI:3628
is: SBO:0000247
boundary condition: false
constant: false
is: C00334
initial amount: NaN
initial concentration: 1.0
is: HMDB00112
type: Species
has only substance units: false

metaR r0553
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110022#
product: MODEL1310110022#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
kinetic law: MODEL1310110022#
reversible: true
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8

metaM cbasp e
type: Species
is: C00438
is: CHEBI:32814
has only substance units: false
name: N-Carbamoyl-L-aspartate
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H6N2O5 CHARGE: -2
is: HMDB00828

metaR r0400
product: MODEL1310110022#
fast: false
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.4.4
type: Reaction
kinetic law: MODEL1310110022#
is described by: ECO:0000000
modifier: MODEL1310110022#
reversible: true
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
reactant: MODEL1310110022#

metaM HC01610 e
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768
is: SBO:0000247
is: CHEBI:28607
constant: false
has only substance units: false
name: CoproporphyrinogenI

metaM leuktrD4 c
has only substance units: false
is: HMDB03080
initial concentration: 1.0
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
type: Species
boundary condition: false
is: CHEBI:28666
constant: false
name: Leukotriene D4
initial amount: NaN
is: SBO:0000247

metaM fadh2 c
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
type: Species
is: HMDB01197
name: FADH2(2-)
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
is: CHEBI:58307

metaR r0281
fast: false
name: Putrescine:oxygen oxidoreductase (deaminating) Urea cycle and metabolism of amino groups EC:1.4.3.6
modifier: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:12072962,PMID:15795708,PMID:17006978,PMID:6403048 NOTES:
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/5.3.1.6
product: MODEL1310110022#
kinetic law: MODEL1310110022#
reversible: true
is described by: ECO:0000000
is: SBO:0000176

metaM pac c
type: Species
is: CHEBI:18401
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: phenylacetate
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
is: SBO:0000247
constant: false
is: HMDB00209

http://identifiers.org/biomodels.db/MODEL1310110022#_4a218699_09ba_4db1_823d_cf58d8e898f3
type: Species
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
name: _AI348006_1_c
initial amount: NaN
is encoded by: hsa:AI348006

metaR NACHEX24ly
type: Reaction
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
reversible: false
product: MODEL1310110022#
fast: false
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

metaR r1752
modifier: MODEL1310110022#
is described by: ECO:0000000
reactant: MODEL1310110022#
product: MODEL1310110022#
fast: false
reversible: false
name: Y+LAT2 Utilized transport
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM pan4p e
is: SBO:0000247
initial amount: NaN
is: HMDB01416
notes: FORMULA: C11H21N2O7PS CHARGE: -2
type: Species
boundary condition: false
is: C01134
name: Pantetheine 4'-phosphate
has only substance units: false
is: CHEBI:47942
constant: false
initial concentration: 1.0

metaM ksii core4 deg4 l
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
is: CHEBI:57455
notes: FORMULA: C66H108N6O48SX CHARGE: -1
boundary condition: false
name: keratan sulfate II (core 4-linked), degradation product 4
is: HMDB01354
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_a24b8bae_ddf9_42bc_b686_b082337168e7
initial concentration: NaN
has only substance units: false
is: P34949
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: MPI
type: Species
is encoded by: hsa:4351

http://identifiers.org/biomodels.db/MODEL1310110022#_fbd84360_f3bd_4546_be7f_e4135afb0ba1
has only substance units: false
is: SBO:0000252
is encoded by: hsa:221823
type: Species
initial amount: NaN
constant: false
is: P21108
initial concentration: NaN
name: PRPS1L1
boundary condition: true

metaM ptrc e
initial amount: NaN
constant: false
is: HMDB01414
initial concentration: 1.0
is: C00134
boundary condition: false
type: Species
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
name: Putrescine
is: CHEBI:326268
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110022#_070917e7_46bc_44c9_8a7a_3439263266f4
type: Species
has only substance units: false
constant: false
is encoded by: hsa:10201
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: NME6
is: O75414

metaR r0974
kinetic law: MODEL1310110022#
is described by: ECO:0000000
fast: false
product: MODEL1310110022#
reactant: MODEL1310110022#
reversible: true
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
name: Active transport

metaM urate c
initial concentration: 1.0
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
is: HMDB00289
boundary condition: false
name: Urate
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:17775
constant: false
is: C00366
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110022#_c9a96967_f868_4638_8d93_09b1363d0a48
is: F8WDN9
type: Species
boundary condition: true
is encoded by: hsa:27068
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: PPA2

metaM 7thf e
is: HMDB06559
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
name: heptaglutamyl folate (THF)
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C49H57N13O24 CHARGE: -8

metaR r1431
is described by: ECO:0000000
type: Reaction
name: 2-Deoxyuridine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Pyrimidine metabolism EC:1.17.4.1
fast: false
reversible: false
is: SBO:0000176
reactant: MODEL1310110022#
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
kinetic law: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_c988b8a0_939a_4b92_9d7d_2f099cafd150
initial amount: NaN
is encoded by: hsa:570
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is: Q14032
type: Species
name: BAAT
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110022#_d2fd77c1_7453_4495_a4f6_32ee716bfee8
is: P09923
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
name: ALPI
is encoded by: hsa:248
boundary condition: true
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_462c3771_018e_4a0d_b57d_d3ee9bbb1b9e
is encoded by: hsa:51733
has only substance units: false
name: UPB1
is: B3KNC1
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false

metaM ksi deg21 l
notes: FORMULA: C132H213N9O114S6 CHARGE: -6
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
is: CHEBI:12936
boundary condition: false
initial amount: NaN
name: keratan sulfate I, degradation product 21
is: SBO:0000247
is: HMDB00143

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

metaR PETOHMr hs
reversible: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110022#
name: phosphatidylethanolamine N-methyltransferase
reactant: MODEL1310110022#
fast: false
is version of: http://identifiers.org/ec-code/2.1.1.17
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-Prot] NJ
product: MODEL1310110022#
modifier: MODEL1310110022#
is described by: ECO:0000254

http://identifiers.org/biomodels.db/MODEL1310110022#_081be461_277a_491b_9a0b_2f0bde4fc29b
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:84706
constant: false
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
name: GPT2
is: Q8TD30

metaM 56dthm c
is: CHEBI:27468
constant: false
has only substance units: false
type: Species
name: 5,6-dihydrothymine
boundary condition: false
initial concentration: 1.0
is: HMDB00079
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
initial amount: NaN
is: SBO:0000247

metaR CERT2rt
fast: false
reactant: MODEL1310110022#
is described by: ECO:0000000
name: ceramide transport protein
reversible: true
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
is version of: http://identifiers.org/ec-code/2.7.11.1
is: SBO:0000185
type: Reaction

metaR r1753
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
type: Reaction
reactant: MODEL1310110022#
product: MODEL1310110022#
fast: false
reversible: false
modifier: MODEL1310110022#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110022#

metaR r0975
product: MODEL1310110022#
name: Facilitated diffusion
fast: false
is described by: ECO:0000000
reversible: false
is: SBO:0000185
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
type: Reaction
kinetic law: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_c3c54659_4cf5_447e_ba69_05f3cd128bd9
boundary condition: true
is encoded by: hsa:3290
constant: false
initial concentration: NaN
is: P28845
is: SBO:0000252
name: HSD11B1
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_abb8cb38_c36d_425e_b3f7_b437e794cf6a
name: DGKB
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:1607
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110022#_7ec68603_6f5f_491b_8245_d2fde965e9c1
is: SBO:0000252
is: P23378
initial amount: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false
name: GLDC
is encoded by: hsa:2731
initial concentration: NaN

metaR r1299
kinetic law: MODEL1310110022#
fast: false
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
name: Vesicular transport
is: SBO:0000185
type: Reaction
reactant: MODEL1310110022#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110022#_a011cc5d_c489_40b2_9585_08a4de7b5b45
is encoded by: hsa:3990
constant: false
initial amount: NaN
is: A6H8L5
is: SBO:0000252
type: Species
has only substance units: false
name: LIPC
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_e3fef30d_0342_4f24_b6b8_593010eb4b66
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
is: P00325
boundary condition: true
is encoded by: hsa:125
name: ADH1B

http://identifiers.org/biomodels.db/MODEL1310110022#_42827357_4e05_4ac1_bf1e_04f8d6d1c149
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
name: HMOX1
type: Species
is: SBO:0000252
is: Q6FH11
is encoded by: hsa:3162
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_5cbfac08_1b89_471c_b1a9_0efaf00c69e8
has only substance units: false
is encoded by: hsa:5161
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
name: PDHA2
is: P29803
boundary condition: true
is: SBO:0000252

metaM fum m
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:29806
type: Species
is: HMDB00134
name: Fumarate
boundary condition: false
initial amount: NaN
is: C00122
initial concentration: 1.0

metaR PI345P5P
notes: GENE_ASSOCIATION: (3633.1) or (27124.1) or (3635.1) or (3636.1) or (8871.1) or (56623.1) or (8867.2) or (27124.2) or (8867.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929 NOTES:NCD
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.1.3.56
modifier: MODEL1310110022#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.36
is described by: ECO:0000000
fast: false
reversible: false
name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
kinetic law: MODEL1310110022#
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.1.3.86

metaR It
is: SBO:0000185
is described by: ECO:0000269
name: Iodide uniport
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
modifier: MODEL1310110022#
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
fast: false
product: MODEL1310110022#
reversible: true
type: Reaction

metaR MI14P4P
type: Reaction
fast: false
kinetic law: MODEL1310110022#
reversible: false
reactant: MODEL1310110022#
product: MODEL1310110022#
name: inositol-1,4-bisphosphate 4-phosphatase
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD

metaR NACHEX13ly
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
product: MODEL1310110022#
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
is: SBO:0000176
is described by: ECO:0000000
fast: false
reactant: MODEL1310110022#
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110022#_ca5b2f12_6b63_4323_a286_dfd7c0c8ed33
is encoded by: hsa:23169
constant: false
is: SBO:0000252
initial concentration: NaN
name: SLC35D1
initial amount: NaN
boundary condition: true
is: Q9NTN3
has only substance units: false
type: Species

metaM urate e
type: Species
has only substance units: false
is: C00366
is: SBO:0000247
is: HMDB00289
initial concentration: 1.0
is: CHEBI:17775
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
name: Urate
initial amount: NaN
boundary condition: false
constant: false

metaM lys L m
constant: false
initial concentration: 1.0
type: Species
name: L-lysinium(1+)
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
has only substance units: false
is: SBO:0000247
is: HMDB00182
boundary condition: false
is: CHEBI:32551
initial amount: NaN

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_1449c545_2c48_43f9_b773_1d7c436c69f4
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:762
name: CA4
is: Q6FHI7

metaR r1540
is version of: http://identifiers.org/ec-code/1.17.4.1
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
product: MODEL1310110022#
reversible: false
fast: false
modifier: MODEL1310110022#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110022#_6b878a2b_566d_48e1_8624_eb0bb74d79b5
name: PMM1
is: SBO:0000252
is encoded by: hsa:5372
is: A8K003
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_5113c38d_50a9_4b95_b19d_9cffd595b633
is: SBO:0000252
is: B4DUG1
is encoded by: hsa:9187
boundary condition: true
has only substance units: false
constant: false
name: SLC24A1
type: Species
initial concentration: NaN
initial amount: NaN

metaM ile L e
boundary condition: false
constant: false
is: HMDB00172
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
name: L-isoleucine
is: CHEBI:17191

metaR EX prostgf2 LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin F2alpha exchange
type: Reaction

metaM f1a g
boundary condition: false
is: CHEBI:17151
is: HMDB02917
notes: FORMULA: C22H37N2O15X CHARGE: 0
type: Species
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: F1alpha
is: SBO:0000247

metaM na1 e
initial concentration: 1.0
is: HMDB00588
notes: FORMULA: Na CHARGE: 1
initial amount: NaN
constant: false
is: SBO:0000247
name: Sodium
type: Species
has only substance units: false
is: C01330
boundary condition: false
is: CHEBI:4541

metaM 10fthf7glu e
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB00972
initial concentration: 1.0
name: 10-formyltetrahydrofolate-[Glu](7)
type: Species
initial amount: NaN
notes: FORMULA: C50H57N13O25 CHARGE: -8
is: CHEBI:57454

http://identifiers.org/biomodels.db/MODEL1310110022#_1d7f1614_af97_4814_912f_c374dbaee186
has only substance units: false
is encoded by: hsa:2224
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
is: P14324
initial amount: NaN
name: FDPS
boundary condition: true

metaM 3pg m
is: CHEBI:58272
is: HMDB00807
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
type: Species
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate

metaM dgtp e
initial amount: NaN
is: HMDB01440
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
constant: false
is: CHEBI:16497
is: SBO:0000247
boundary condition: false
name: dGTP

metaM leuktrE4 c
has only substance units: false
constant: false
is: HMDB02200
name: leukotriene E4(1-)
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:57462
initial concentration: 1.0
initial amount: NaN

metaR TKT1
type: Reaction
reversible: true
fast: false
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.2.1.1
name: transketolase
is described by: ECO:0000000
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000176
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2

metaR UMPK5n
reactant: MODEL1310110022#
modifier: MODEL1310110022#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110022#
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (dATP),nuclear
is described by: ECO:0000269
fast: false
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM datp c
has only substance units: false
is: C00131
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: HMDB01532
type: Species
name: dATP
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:61404

http://identifiers.org/biomodels.db/MODEL1310110022#_e21e2f39_2a53_464b_a04a_db2237a3de8f
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:51
name: ACOX1
has only substance units: false
is: B4DK61
boundary condition: true
constant: false
is: SBO:0000252

metaR UGLCNACtg
fast: false
is: SBO:0000185
reversible: true
modifier: MODEL1310110022#
type: Reaction
reactant: MODEL1310110022#
name: UDP-GlcNAc Golgi transport via CMP antiport
is described by: ECO:0000269
product: MODEL1310110022#
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110022#_95d5ccb0_34be_46ea_b8d0_dc2d191a248a
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
type: Species
name: OGDHL
is: Q9ULD0
boundary condition: true
is encoded by: hsa:55753
is: SBO:0000252

metaR r0885
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110022#
reversible: true
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
kinetic law: MODEL1310110022#
fast: false
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.3.1.38
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
reactant: MODEL1310110022#

metaM udp l
type: Species
name: UDP(3-)
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
initial concentration: 1.0
boundary condition: false
is: CHEBI:58223
is: HMDB00295
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_a3ad10e5_86af_4046_af30_168ef44c6cca
is encoded by: hsa:5313
initial concentration: NaN
is: SBO:0000252
name: PKLR
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
is: P30613
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_a6565517_e91b_4bff_828e_363ad39f6241
type: Species
is: SBO:0000252
boundary condition: true
is: Q8N3E9
name: PLCD3
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:113026
initial amount: NaN

metaM g6p r
has only substance units: false
is: HMDB01401
is: SBO:0000247
boundary condition: false
is: CHEBI:61548
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
is: C00092
type: Species
name: D-Glucose 6-phosphate

metaR FAOXC22OHC22r
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(C22-->w-OHC22)er
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_63b98cc8_9b96_4e5c_a4a6_a83f463a22aa
boundary condition: true
constant: false
type: Species
name: OGDHL
is: Q9ULD0
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:55753
is: SBO:0000252

metaR PECGCHLe
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: binding of pectins with glycocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

metaM xol27oh r
boundary condition: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:17703
is: SBO:0000247
initial concentration: 1.0
name: 26-hydroxycholesterol
constant: false
is: HMDB02103

metaR GLCNACASE5ly
modifier: MODEL1310110022#
fast: false
product: MODEL1310110022#
reactant: MODEL1310110022#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.50
name: alpha-N-acetylglucosaminidase, lysosomal
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
reversible: false
kinetic law: MODEL1310110022#

metaR S6TASE25ly
modifier: MODEL1310110022#
reactant: MODEL1310110022#
name: galactose-6-sulfate sulfatase, lysosomal
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

metaR r0946
product: MODEL1310110022#
type: Reaction
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
kinetic law: MODEL1310110022#
reversible: true

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

metaM CE5586 c
has only substance units: false
notes: FORMULA: C7H20N3 CHARGE: 3 INCHI: InChI=1S/C7H17N3/c8-4-1-2-6-10-7-3-5-9/h6H,1-5,7-9H2/p+3/b10-6+ EHMN_ABBREVIATION: CE5586
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:58732
boundary condition: false
name: N-[(E)-4-ammoniobutylidene]propane-1,3-diaminium
initial concentration: 1.0

metaM 3mop m
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
has only substance units: false
is: HMDB00491
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
name: 3-methyl-2-oxopentanoate
constant: false
is: CHEBI:28654
initial amount: NaN

metaR TKT2
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
reversible: true
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
name: transketolase
product: MODEL1310110022#
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.2.1.1
is: SBO:0000176

metaM oaa m
initial concentration: 1.0
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
is: HMDB00223
is: C00036
constant: false
is: CHEBI:16452
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
name: Oxaloacetate

metaR r0556
kinetic law: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
reversible: true
reactant: MODEL1310110022#
is described by: ECO:0000000
modifier: MODEL1310110022#
fast: false
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.19.1
product: MODEL1310110022#

metaR RE3272N
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
name: RE3272
reversible: true
is: SBO:0000176
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
product: MODEL1310110022#
is described by: ECO:0000000

metaR NDPK8n
type: Reaction
modifier: MODEL1310110022#
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000304
is: SBO:0000176
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
product: MODEL1310110022#
reversible: true
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
fast: false

metaR r2012
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110022#
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110022#
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaR RETI2
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
name: retinol isomerase (9-cis)
type: Reaction
fast: false
product: MODEL1310110022#
is: SBO:0000176
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000000
reversible: true

metaM nh4 x
is: HMDB00051
initial concentration: 1.0
initial amount: NaN
is: CHEBI:28938
boundary condition: false
name: Ammonium
constant: false
type: Species
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
has only substance units: false
is: C01342
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110022#_c6bf44ae_cd12_42df_9a46_492c30b5019c
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
name: ALDH7A1
is: E7EPT3
constant: false
is: SBO:0000252
is encoded by: hsa:501
has only substance units: false

metaR ALOX52
type: Reaction
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:cofactors + usage still not clear unknown mechanism - biochemistry supported by PMID: 2829172, 11160764
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110022#
fast: false
name: Arachidonate 5-lipoxygenase
is version of: http://identifiers.org/ec-code/1.13.11.34
modifier: MODEL1310110022#
product: MODEL1310110022#
is: SBO:0000176

metaM leuktrE4 e
has only substance units: false
type: Species
name: leukotriene E4(1-)
is: SBO:0000247
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
boundary condition: false
is: CHEBI:57462
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB02200

metaR TRDR
type: Reaction
kinetic law: MODEL1310110022#
product: MODEL1310110022#
fast: false
is: SBO:0000176
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.8.1.9
name: thioredoxin reductase (NADPH)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
reactant: MODEL1310110022#
reversible: false

metaR DHPM1
reversible: false
fast: false
kinetic law: MODEL1310110022#
product: MODEL1310110022#
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.2.2
name: dihydropyrimidinase (5,6-dihydrouracil)
is: SBO:0000176
reactant: MODEL1310110022#

metaM udp n
type: Species
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
name: UDP(3-)
initial concentration: 1.0
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: CHEBI:58223
is: HMDB00295
boundary condition: false

metaM tcynt e
boundary condition: false
type: Species
name: thiocyanate
is: HMDB01453
initial concentration: 1.0
is: CHEBI:18022
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_953ff676_052d_45aa_b812_e80a74628ac2
has only substance units: false
type: Species
constant: false
is: B7Z4Y6
name: ALPL
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:249
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_1da03a05_2640_4dac_8b8f_977093915578
is encoded by: hsa:65010
type: Species
boundary condition: true
is: SBO:0000252
constant: false
is: Q548A7
initial concentration: NaN
has only substance units: false
name: SLC26A6
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_7ea9563c_5d77_4eee_8d12_1054f1589a91
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6554
is: B2RA41
constant: false
initial amount: NaN
boundary condition: true
name: SLC10A1
has only substance units: false
type: Species

metaR GLUDym
is version of: http://identifiers.org/ec-code/1.4.1.3
is: SBO:0000176
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
is described by: ECO:0000269
modifier: MODEL1310110022#
reversible: true
reactant: MODEL1310110022#
fast: false
type: Reaction
product: MODEL1310110022#
name: glutamate dehydrogenase (NADP), mitochondrial

metaR r0295
modifier: MODEL1310110022#
reactant: MODEL1310110022#
fast: false
reversible: false
name: glycine synthase Nitrogen metabolism EC:2.1.2.10
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110022#
is described by: ECO:0000000
product: MODEL1310110022#

metaM ksi deg34 l
is: HMDB01354
constant: false
is: SBO:0000247
is: CHEBI:57455
notes: FORMULA: C76H126N5O59S1 CHARGE: -1
type: Species
initial concentration: 1.0
boundary condition: false
name: keratan sulfate I, degradation product 34
initial amount: NaN
has only substance units: false

metaR RE0383C
is version of: http://identifiers.org/ec-code/1.1.1.2
type: Reaction
kinetic law: MODEL1310110022#
is described by: ECO:0000000
name: RE0383
reactant: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
product: MODEL1310110022#
reversible: true
modifier: MODEL1310110022#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110022#_2a9244ad_0029_4adb_9083_3ac513824708
has only substance units: false
constant: false
is encoded by: hsa:AA021081
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: _AA021081_1_r
type: Species

metaM ksi deg27 l
is: CHEBI:12936
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C104H169N7O88S4 CHARGE: -4
is: HMDB00143
name: keratan sulfate I, degradation product 27
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_bb355d69_7856_4999_85f4_f448d8c5de74
type: Species
has only substance units: false
name: ACSL4
is encoded by: hsa:2182
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: Q5JWV8
constant: false
initial amount: NaN

metaM dcyt e
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
type: Species
has only substance units: false
constant: false
name: Deoxycytidine
boundary condition: false
is: CHEBI:15698
is: HMDB00014
initial concentration: 1.0
is: C00881
initial amount: NaN
is: SBO:0000247

metaR ASPPROASCT1
fast: false
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reversible: false
modifier: MODEL1310110022#
is described by: ECO:0000134
reactant: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: (6509.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14502423, PMID: 11824937, Kim E. Barrett, Mark Donowitz (2001) Gastrointestinal transport: Molecular physiology, Academic press, A harcourt science and technology company, chapter 10, pages 389-391. NOTES:ASCT-1 transport system operates at the basolateral surface, acts as an amino acid exchanger. Preferred substrates are small neutral amino acids, however shown to have transport proline and hydroxy-proline. At acidic ph also transports aspartate and glutamate. the ASCT-1 operates in a similar mechanism as ASCT-2.
is: SBO:0000185
name: aspartate intake by system ASCT-1 transporter

metaM dtdp c
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: HMDB01274
is: CHEBI:58369
constant: false
initial amount: NaN
has only substance units: false
is: C00363
name: dTDP
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110022#_bf4b3d18_2ce7_48ec_a8a6_5f9d462ce976
constant: false
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
name: _AI620219_1_c
initial concentration: NaN
is encoded by: hsa:AI620219

metaR DNDPt8m
modifier: MODEL1310110022#
product: MODEL1310110022#
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
name: dADP transport via dUDP antiport
reversible: false
is described by: ECO:0000269
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_25902c69_4aba_416a_aa93_5747900e0411
constant: false
is encoded by: hsa:54995
is: SBO:0000252
is: Q9NWU1
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: OXSM
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_e3ec8c8f_a6d5_47e2_88f6_0e2ef5f51490
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5167
name: ENPP1
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
is: P22413
constant: false

metaR A MANASEly
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.24
notes: GENE_ASSOCIATION: (4125.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES:NCD
modifier: MODEL1310110022#
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
name: alpha-mannosidase, lysosomal
type: Reaction
fast: false
reversible: false
product: MODEL1310110022#
is described by: ECO:0000000

metaM thr L c
type: Species
is: CHEBI:16857
is: SBO:0000247
constant: false
is: HMDB00167
name: L-threonine
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
initial amount: NaN
boundary condition: false

metaR G3PD1
reactant: MODEL1310110022#
reversible: true
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
type: Reaction
name: glycerol-3-phosphate dehydrogenase (NAD)
is version of: http://identifiers.org/ec-code/1.1.1.8
modifier: MODEL1310110022#
is: SBO:0000176
product: MODEL1310110022#
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110022#_02746ca6_a6e3_4fbb_a3fe_18d84f522dc6
type: Species
has only substance units: false
name: NMNAT2
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:23057
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110022#_7773ffa7_1034_4784_9926_1f6660e0a29d
has only substance units: false
type: Species
is: Q9BZQ4
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:23057
boundary condition: true
name: NMNAT2

http://identifiers.org/biomodels.db/MODEL1310110022#_73b7c749_837f_4577_b70e_6ab362caf77c
type: Species
initial concentration: NaN
is: P59796
name: GPX6
constant: false
boundary condition: true
is encoded by: hsa:257202
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

metaM ksii core4 e
initial amount: NaN
initial concentration: 1.0
name: keratan sulfate II (core 4-linked)
is: CHEBI:17268
constant: false
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB00211

metaR GLCAASE1ly
fast: false
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
type: Reaction
product: MODEL1310110022#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
name: beta-glucuronidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.31

http://identifiers.org/biomodels.db/MODEL1310110022#_f4205e5a_5b8c_45a3_8581_defa891d97db
initial amount: NaN
type: Species
name: FECH
is: SBO:0000252
has only substance units: false
boundary condition: true
is: Q7KZA3
is encoded by: hsa:2235
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_a9a1a7d7_0884_4e2e_a820_4f2b95ab32ce
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
name: NDUFV1
is: E5KNH5
is encoded by: hsa:4723
initial amount: NaN

metaM na1 r
constant: false
is: HMDB00588
name: sodium(1+)
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:29101
has only substance units: false
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
boundary condition: false
initial amount: NaN
type: Species

metaM C02528 c
constant: false
is: SBO:0000247
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
initial concentration: 1.0
is: HMDB00518
is: CHEBI:36234
type: Species
initial amount: NaN
name: chenodeoxycholate
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110022#_52319692_de44_4a4a_a50c_17fd1cc1d360
is: P00374
name: DHFR
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:1719

metaR HACD9m
modifier: MODEL1310110022#
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
reactant: MODEL1310110022#
is: SBO:0000176
fast: false
product: MODEL1310110022#
kinetic law: MODEL1310110022#
reversible: true
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_5c70dddd_ed9f_488d_951a_00a144657fe0
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is: P05091
name: ALDH2
boundary condition: true
initial amount: NaN
is encoded by: hsa:217

http://identifiers.org/biomodels.db/MODEL1310110022#_04ade77f_bd05_473f_ae4f_88595f472b0a
is encoded by: hsa:4705
type: Species
is: O95299
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
name: NDUFA10

metaM abt c
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
is: CHEBI:18403
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
name: L-arabinitol
has only substance units: false
is: HMDB01851
constant: false

metaR r0881
fast: false
is described by: ECO:0000000
name: Active transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12107270,PMID:12739169,PMID:12829793,PMID:17245649,PMID:18375207,PMID:8476015,PMID:8557697,PMID:9786900 NOTES:
type: Reaction
reactant: MODEL1310110022#
is: SBO:0000185
kinetic law: MODEL1310110022#
reversible: false
product: MODEL1310110022#

metaR OROTGLUt
reversible: true
name: OROTGLUt
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110022#
type: Reaction
kinetic law: MODEL1310110022#
is: SBO:0000185
fast: false
is described by: ECO:0000134

metaR GMPR
product: MODEL1310110022#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.7.1.7
notes: GENE_ASSOCIATION: (2766.1) or (51292.1) or (51292.3) or (51292.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.1.7 Confidence Level: 4 AUTHORS: PMID:12009299,PMID:8188226 NOTES:
kinetic law: MODEL1310110022#
name: GMP reductase
reactant: MODEL1310110022#
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110022#
reversible: false

metaM thcholstoic m
boundary condition: false
is: SBO:0000247
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
initial concentration: 1.0
is: HMDB03873
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:18402

metaR MMTSADm
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1527093 NOTES:MM. biochemical activity measured in rat, sequence similarity found in human
product: MODEL1310110022#
fast: false
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
is described by: ECO:0000000
name: malonate-semialdehyde dehydrogenase (acetylating), mitochondrial
type: Reaction

metaR r0149
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
is version of: http://identifiers.org/ec-code/1.14.13.39
product: MODEL1310110022#
reversible: true
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
reactant: MODEL1310110022#
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000000

metaR HS3ly
reversible: false
name: heparan-N-sulfatase, lysosomal
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.10.1.1
is described by: ECO:0000000
kinetic law: MODEL1310110022#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
modifier: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#

metaM dtdp e
is: SBO:0000247
is: HMDB01274
constant: false
boundary condition: false
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
is: CHEBI:58369
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_9d0b72a7_4ac4_4420_bdb2_da5b3c3711aa
name: ALDH1A2
is: SBO:0000252
boundary condition: true
is: F5H2Y9
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:8854
constant: false

metaR TPI
reactant: MODEL1310110022#
is: SBO:0000176
name: triose-phosphate isomerase
product: MODEL1310110022#
reversible: true
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
fast: false
type: Reaction
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/5.3.1.1
is described by: ECO:0000134
modifier: MODEL1310110022#

metaM i c
is: SBO:0000247
initial concentration: 1.0
is: HMDB12238
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
type: Species
initial amount: NaN
name: iodide
has only substance units: false
is: CHEBI:16382
constant: false
boundary condition: false

metaM HC01434 c
boundary condition: false
type: Species
has only substance units: false
name: oxalatosuccinate(3-)
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
is: SBO:0000247
is: CHEBI:58931
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_ef339a78_4cd1_4c6c_91c8_016ba7a3a683
type: Species
is encoded by: hsa:206
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: _206_1_c

http://identifiers.org/biomodels.db/MODEL1310110022#_f3b1a93b_21cb_44ff_80e2_1acad677a49d
name: PLD2
initial concentration: NaN
initial amount: NaN
is: O14939
is: SBO:0000252
has only substance units: false
constant: false
type: Species
is encoded by: hsa:5338
boundary condition: true

metaR CYANtm
is: SBO:0000185
type: Reaction
name: Cyanide transport via diffusion (mitochondrial)
reactant: MODEL1310110022#
reversible: true
fast: false
kinetic law: MODEL1310110022#
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:assumed to be readily diffusible MM
is described by: ECO:0000000

metaM thr L e
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB00167
name: L-threonine
initial amount: NaN
type: Species
is: CHEBI:16857
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
has only substance units: false

metaM oxa x
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
type: Species
is: HMDB02329
initial concentration: 1.0
boundary condition: false
name: oxalate(2-)
is: CHEBI:30623
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaM idp n
type: Species
constant: false
is: CHEBI:58280
initial concentration: 1.0
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB03335
boundary condition: false
name: IDP(3-)

metaR r1750
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110022#
reversible: false
fast: false
type: Reaction
product: MODEL1310110022#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_0d1e1581_1ecc_423d_883c_380424cd9046
is encoded by: hsa:51109
type: Species
is: B4DDW0
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
name: RDH11

metaM ksi deg25 l
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:57455
name: keratan sulfate I, degradation product 25
initial amount: NaN
is: HMDB01354
constant: false
notes: FORMULA: C118H192N8O98S4 CHARGE: -4
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110022#_a0d8daae_a362_48e7_84e7_5e4955b00c80
boundary condition: true
initial concentration: NaN
name: PLCB3
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:5331
initial amount: NaN
is: G5E960
type: Species

metaR r0559
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
reversible: true
product: MODEL1310110022#
type: Reaction
reactant: MODEL1310110022#
is described by: ECO:0000000
kinetic law: MODEL1310110022#
fast: false
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.5.1.3
is: SBO:0000176

metaM hs deg25 l
boundary condition: false
is: CHEBI:15748
notes: FORMULA: C23H37O21 CHARGE: -1
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB00127
constant: false
name: GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
has only substance units: false

metaR r1527
is version of: http://identifiers.org/ec-code/4.2.1.1
type: Reaction
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
reversible: false
modifier: MODEL1310110022#
product: MODEL1310110022#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
is: SBO:0000185

metaR FAS160COA
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110022#
is described by: ECO:0000269
name: fatty-acyl-CoA synthase (n-C16:0CoA)
fast: false
reversible: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
is: SBO:0000176
reactant: MODEL1310110022#
type: Reaction

metaM dgtp c
boundary condition: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
is: CHEBI:16497
has only substance units: false
is: HMDB01440
is: C00286
name: dGTP

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaM ksii core2 deg1 l
is: SBO:0000247
is: HMDB00868
notes: FORMULA: C70H113N5O59S3X CHARGE: -3
boundary condition: false
is: CHEBI:57737
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
name: keratan sulfate II (core 2-linked), degradation product 1
initial amount: NaN

metaM udp r
name: UDP
initial concentration: 1.0
type: Species
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: CHEBI:58223
constant: false
is: HMDB00295
is: SBO:0000247
boundary condition: false
is: C00015
initial amount: NaN
has only substance units: false

metaM 3mox4hoxm c
has only substance units: false
boundary condition: false
is: HMDB00291
notes: FORMULA: C9H9O5 CHARGE: -1 INCHI: InChI=1S/C9H10O5/c1-14-7-4-5(2-3-6(7)10)8(11)9(12)13/h2-4,8,10-11H,1H3,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC01521 EHMN_ABBREVIATION: C05584
initial amount: NaN
initial concentration: 1.0
name: 3-Methoxy-4-hydroxymandelate
constant: false
is: SBO:0000247
type: Species
is: CHEBI:27622

metaR GALASE7ly
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
modifier: MODEL1310110022#
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
reversible: false
name: beta-galactosidase, lysosomal
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110022#

metaR GGH 7DHFe
modifier: MODEL1310110022#
is described by: ECO:0000000
reversible: false
product: MODEL1310110022#
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.4.19.9
name: Gamma-glutamyl hydrolase (7DHF), extracellular
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
kinetic law: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_ad82f43d_7f00_431d_ac2c_a2829dc6dea7
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

metaR LPS2
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.1.1.34
is: SBO:0000176
fast: false
name: lipase
notes: GENE_ASSOCIATION: (4023.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.3 Confidence Level: 4 AUTHORS: PMID:1969408 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
product: MODEL1310110022#
reactant: MODEL1310110022#
reversible: false

metaM abt e
is: CHEBI:18403
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB01851
constant: false
name: L-arabinitol
has only substance units: false

metaR SRTNtu
type: Reaction
is: SBO:0000185
reversible: true
modifier: MODEL1310110022#
name: Serotonin uniport
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (6580.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
fast: false
product: MODEL1310110022#
is described by: ECO:0000269

metaR UDPtl
type: Reaction
reactant: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ
kinetic law: MODEL1310110022#
name: udp intracellular transport
product: MODEL1310110022#
is described by: ECO:0000000
reversible: true
is: SBO:0000185

metaR GLYCtm
kinetic law: MODEL1310110022#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
product: MODEL1310110022#
name: glycerol transport
type: Reaction
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
fast: false

metaR PPItx
is: SBO:0000185
kinetic law: MODEL1310110022#
type: Reaction
reversible: true
fast: false
product: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000000
name: Diphosphate transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_f7ecb9c9_3b7c_4cf7_96f9_f5d0a3abe70b
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1103
initial amount: NaN
name: CHAT
has only substance units: false
constant: false
type: Species
boundary condition: true
is: D3DX95

metaR S6TASE22ly
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false
is described by: ECO:0000000
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
is: SBO:0000176
name: galactose-6-sulfate sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110022#
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5

metaR r0558
fast: false
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
type: Reaction
product: MODEL1310110022#
is described by: ECO:0000000
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.5.1.3
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
reversible: true
is: SBO:0000176
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29

http://identifiers.org/biomodels.db/MODEL1310110022#_b9f9d2dd_8c45_4320_8f2d_ff424c57ffc5
name: PANK4
has only substance units: false
initial concentration: NaN
is encoded by: hsa:55229
is: SBO:0000252
boundary condition: true
is: Q9NVE7
constant: false
type: Species
initial amount: NaN

metaM anth e
is: SBO:0000247
constant: false
name: anthranilate
has only substance units: false
is: CHEBI:16567
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB01123
type: Species
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1

metaM glyc3p c
initial concentration: 1.0
is: HMDB00126
is: C00093
type: Species
constant: false
boundary condition: false
initial amount: NaN
name: Glycerol 3-phosphate
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: SBO:0000247
is: CHEBI:57597
has only substance units: false

metaR RE0935E
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.1
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110022#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.17
modifier: MODEL1310110022#
product: MODEL1310110022#
type: Reaction
fast: false
name: RE0935
kinetic law: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_fce8012a_e554_4fb2_a4e7_b54a6f6bf8f8
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AI191472
type: Species
boundary condition: true
name: _AI191472_1_c

http://identifiers.org/biomodels.db/MODEL1310110022#_d3e626f3_fa6a_499c_baab_568eefac24d3
is encoded by: hsa:377677
name: CA13
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
type: Species
is: SBO:0000252
is: Q8N1Q1
initial amount: NaN

metaM i e
is: HMDB12238
constant: false
initial concentration: 1.0
is: SBO:0000247
name: iodide
initial amount: NaN
has only substance units: false
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
boundary condition: false
is: CHEBI:16382
type: Species

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

metaM pmtcrn x
is: SBO:0000247
is: HMDB00222
type: Species
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:17490
name: L-palmitoylcarnitine

http://identifiers.org/biomodels.db/MODEL1310110022#_c84cdb90_c5d1_431f_940c_48c80516d3d4
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: ACAT1
constant: false
type: Species
is encoded by: hsa:38
initial amount: NaN
is: P24752

metaM HC01403 m
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
boundary condition: false
is: SBO:0000247
constant: false
name: (S)-Hydroxydecanoyl-CoA
is: CHEBI:28325
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_90e727b8_0318_4d33_9ffb_45a8d4588650
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: NDUFB3
constant: false
boundary condition: true
is: Q6IB80
is encoded by: hsa:4709
initial amount: NaN

metaR DOLGLCP Lter
reversible: false
reactant: MODEL1310110022#
is: SBO:0000185
kinetic law: MODEL1310110022#
name: Dolichyl beta-D-glucosyl phosphate flippase (liver)
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_b84208db_2390_4a7c_b264_e070bdbf0d9b
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: Q7GXY8
is encoded by: hsa:4512
constant: false
name: COX1
boundary condition: true
is: SBO:0000252
type: Species

metaM man1p c
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB06330
name: D-Mannose 1-phosphate
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
is: CHEBI:35374
has only substance units: false

metaM CE2705 n
boundary condition: false
is: HMDB02281
is: SBO:0000247
is: CHEBI:15374
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
initial amount: NaN
constant: false
name: quinonoid dihydrobiopterin

http://identifiers.org/biomodels.db/MODEL1310110022#_51f8885b_9654_48fd_9370_5755b79226cf
type: Species
initial amount: NaN
is encoded by: hsa:1607
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
name: DGKB
is: Q9Y6T7
is: SBO:0000252

metaR r2371
kinetic law: MODEL1310110022#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
product: MODEL1310110022#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110022#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaR r2519
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: Utilized transport
reversible: true
reactant: MODEL1310110022#
product: MODEL1310110022#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110022#_53b023ff_2b55_4a26_913d_c399bcfb72e3
is: P41222
is encoded by: hsa:5730
initial concentration: NaN
name: PTGDS
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_1653a93b_48cf_4ec9_a1e4_d59424b1a179
constant: false
is encoded by: hsa:9856
name: DYLX2
is: F5H123
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110022#_a8e26790_445d_4f07_bc13_469e5798f0ee
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
constant: false
name: HMGCS2
is encoded by: hsa:3158
boundary condition: true
is: P54868

metaR RBTt
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110022#
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
type: Reaction
name: ribitol transport via passive diffusion
product: MODEL1310110022#
reactant: MODEL1310110022#

metaR ABO1g
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
type: Reaction
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
is described by: ECO:0000269
product: MODEL1310110022#
reversible: false
fast: false
reactant: MODEL1310110022#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.37
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ

metaM oxa c
is: HMDB02329
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
constant: false
is: CHEBI:30623
initial concentration: 1.0
has only substance units: false
name: oxalate(2-)

metaM ksi e
has only substance units: false
initial amount: NaN
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
name: keratan sulfate I
is: CHEBI:17268
boundary condition: false
is: HMDB00211

metaR EX C02528 LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chenodeoxycholate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_0f628cfa_ec64_42bc_9c1f_eb7becb4ea09
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:5538
type: Species
has only substance units: false
initial concentration: NaN
name: PPT1
boundary condition: true
is: Q6FGQ4

metaR EX akg LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Oxoglutarate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_432171cd_72a4_4edc_8013_ec3103d1d7e6
is: SBO:0000252
is: P47989
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:7498
type: Species
name: XDH
boundary condition: true
initial amount: NaN

metaR RE3524R
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110022#
product: MODEL1310110022#
name: RE3524
reactant: MODEL1310110022#
reversible: true
type: Reaction
is: SBO:0000176
fast: false

metaR r0145
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.8.3.1
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
modifier: MODEL1310110022#
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
product: MODEL1310110022#

metaR EX cbasp LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-carbamoyl-L-aspartate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_d9be0465_e93f_431b_80ce_de9f69db4e25
is encoded by: hsa:NOS2A
is: SBO:0000252
name: _NOS2A_1_c
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false

metaR MANtly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
name: mannose efflux from lysosome
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reversible: false
reactant: MODEL1310110022#

metaR ACETONEt2m
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000185
fast: false
modifier: MODEL1310110022#
type: Reaction
reversible: true
is described by: ECO:0000000
name: acetone mitochondrial transport via proton symport
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
product: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_cc7d1e59_8ca1_48ef_92c8_e0d58d5efda0
is encoded by: hsa:AU149534
name: _AU149534_1_m
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
has only substance units: false

metaR RE3301C
product: MODEL1310110022#
name: RE3301
reactant: MODEL1310110022#
modifier: MODEL1310110022#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.4
reversible: true
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:11182251 NOTES:
fast: false
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110022#_d7429bb7_e61c_4487_b4be_5cbda2e41097
is: SBO:0000252
is encoded by: hsa:T83654
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
name: _T83654_1_c

metaM pmtcrn r
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
name: L-palmitoylcarnitine
is: CHEBI:17490
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB00222

http://identifiers.org/biomodels.db/MODEL1310110022#_e2dbb609_7547_40d9_b09d_2ac83ad186fa
boundary condition: true
type: Species
is: O00462
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4126
is: SBO:0000252
constant: false
initial amount: NaN
name: MANBA

metaM 3mop e
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
constant: false
is: HMDB00491
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: 3-methyl-2-oxopentanoate
type: Species
is: CHEBI:28654
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_91c0c000_ec24_4267_82af_381f5e7099bb
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
name: PEMT
type: Species
has only substance units: false
is encoded by: hsa:10400
is: SBO:0000252

metaM 5HPET c
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
is: HMDB01193
is: CHEBI:57450
has only substance units: false
initial amount: NaN
name: 5(S)-HPETE(1-)
constant: false

metaM ksi deg31 l
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
constant: false
is: HMDB01354
initial amount: NaN
name: keratan sulfate I, degradation product 31
notes: FORMULA: C90H148N6O72S2 CHARGE: -2
is: CHEBI:57455
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110022#_efde062c_3719_4662_a50d_6b7cc4e1e3e8
is: Q8IZH9
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2643
constant: false
type: Species
boundary condition: true
name: GCH1

metaR NCKt
name: Na+/Ca2+-K+ exchange
is: SBO:0000185
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
type: Reaction
reversible: true
kinetic law: MODEL1310110022#
fast: false
reactant: MODEL1310110022#
is described by: ECO:0000269
modifier: MODEL1310110022#
product: MODEL1310110022#

metaR MAGt
reactant: MODEL1310110022#
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110022#
reversible: true
name: monoacylglycerol 2 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:10344773 NOTES:
is described by: ECO:0000269
product: MODEL1310110022#

metaM 10fthf m
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB00972
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: CHEBI:57454
type: Species
name: 10-formyltetrahydrofolate(2-)

metaM CE2705 c
constant: false
initial amount: NaN
name: quinonoid dihydrobiopterin
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:36781
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_882a1392_eba5_4350_adcc_cfc173938383
constant: false
is encoded by: hsa:26275
has only substance units: false
name: HIBCH
is: SBO:0000252
boundary condition: true
is: Q6NVY1
initial amount: NaN
initial concentration: NaN
type: Species

metaR HYXNt
reversible: true
modifier: MODEL1310110022#
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110022#
kinetic law: MODEL1310110022#
name: Hypoxanthine transport
is described by: ECO:0000269
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv

metaM anth c
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB01123
boundary condition: false
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
is: CHEBI:16567
constant: false
name: anthranilate

metaM hco3 e
is: C00288
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
initial concentration: 1.0
is: HMDB00595
is: CHEBI:17544
has only substance units: false
name: Bicarbonate
constant: false
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247

metaR r0669
is described by: ECO:0000000
reactant: MODEL1310110022#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
kinetic law: MODEL1310110022#
fast: false
is: SBO:0000176
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
product: MODEL1310110022#
type: Reaction

metaR O2St
name: superoxide anion transport via diffusion (extracellular)
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:

metaR r2443
type: Reaction
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
product: MODEL1310110022#
is: SBO:0000185
fast: false

metaR r0142
fast: false
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
reversible: false
is: SBO:0000176
is described by: ECO:0000000
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
product: MODEL1310110022#
kinetic law: MODEL1310110022#
type: Reaction
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.6.1.5
reactant: MODEL1310110022#

metaR BTNt2
fast: false
is: SBO:0000185
kinetic law: MODEL1310110022#
name: Biotin reversible transport via proton symport
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD
reactant: MODEL1310110022#
modifier: MODEL1310110022#
product: MODEL1310110022#
reversible: true
is described by: ECO:0000269

metaM dcyt n
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
name: 2'-deoxycytidine
is: CHEBI:15698
is: HMDB00014
initial amount: NaN
type: Species
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaM biliverd c
is: CHEBI:57991
is: HMDB01008
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C33H32N4O6 CHARGE: -2 INCHI: InChI=1S/C33H34N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-15,35H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14-,28-15- EHMN_ABBREVIATION: C00500
has only substance units: false
is: SBO:0000247
name: biliverdin(2-)
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110022#_70f69d50_d62a_459d_bdfc_5a8941df1098
boundary condition: true
is: P40926
initial concentration: NaN
name: MDH2
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:4191
initial amount: NaN
constant: false

metaR S6TASE12ly
type: Reaction
name: N-acetylglucosamine-6-sulfatase, lysosomal
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.14
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
fast: false
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
reversible: true
product: MODEL1310110022#
is: SBO:0000176
reactant: MODEL1310110022#

metaM C02528 e
initial amount: NaN
is: CHEBI:36234
type: Species
boundary condition: false
is: HMDB00518
is: SBO:0000247
name: chenodeoxycholate
has only substance units: false
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
initial concentration: 1.0
constant: false

metaR BDHm
is: SBO:0000176
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
reactant: MODEL1310110022#
modifier: MODEL1310110022#
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
is version of: http://identifiers.org/ec-code/1.1.1.30
reversible: true
product: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_97739b77_c52b_44f1_8663_7848fa27a711
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
name: ST20
is: SBO:0000252
is encoded by: hsa:400410
is: Q9HBF5
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_1cedabae_84f5_492d_85c2_14c2c3cbe25b
initial amount: NaN
is encoded by: hsa:641371
name: ACOT1
has only substance units: false
is: E9KL42
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN

metaR r0668
is described by: ECO:0000000
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.4.2.19
product: MODEL1310110022#
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
is: SBO:0000176
reactant: MODEL1310110022#
reversible: true
type: Reaction
fast: false

metaR r0774
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
type: Reaction
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110022#
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110022#
is: SBO:0000176
kinetic law: MODEL1310110022#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17

metaM mev R c
type: Species
initial amount: NaN
is: HMDB00227
name: (R)-mevalonate
boundary condition: false
constant: false
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
initial concentration: 1.0
is: CHEBI:36464
is: SBO:0000247
has only substance units: false

metaR PRPPS
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.6.1
type: Reaction
product: MODEL1310110022#
reversible: true
fast: false
is: SBO:0000176
reactant: MODEL1310110022#
modifier: MODEL1310110022#
name: phosphoribosylpyrophosphate synthetase
kinetic law: MODEL1310110022#

metaR CHLtm
is described by: ECO:0000000
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
fast: false
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10984 NOTES:
type: Reaction
reversible: true
is: SBO:0000185
name: choline transport via diffusion (cytosol to mitochondria)

metaM occoa m
constant: false
name: Octanoyl-CoA (n-C8:0CoA)
has only substance units: false
type: Species
is: HMDB01070
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57386
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
initial amount: NaN
is: C01944

metaM 3mop c
name: 3-methyl-2-oxopentanoate
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
is: SBO:0000247
initial amount: NaN
is: HMDB00491
type: Species
is: CHEBI:28654
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false

metaM pep m
is: HMDB00263
is: CHEBI:18021
name: Phosphoenolpyruvate
is: C00074
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
type: Species

metaM hmgcoa m
type: Species
has only substance units: false
boundary condition: false
name: Hydroxymethylglutaryl-CoA
initial concentration: 1.0
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
initial amount: NaN
is: CHEBI:15467
constant: false
is: SBO:0000247
is: HMDB01375

metaR RE0912C
notes: GENE_ASSOCIATION: (25830.1) SUBSYSTEM: Tyrosine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10199779,PMID:11397879,PMID:12039030,PMID:8767510,PMID:9463486 NOTES:
fast: false
is described by: ECO:0000000
reversible: false
is: SBO:0000176
product: MODEL1310110022#
modifier: MODEL1310110022#
name: RE0912
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_5652ca52_e34a_440a_b9c3_a6e6e26c59af
boundary condition: true
initial concentration: NaN
name: GAPDHS
is: SBO:0000252
is encoded by: hsa:26330
constant: false
has only substance units: false
is: O14556
type: Species
initial amount: NaN

metaR ITPtn
kinetic law: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185
reversible: true
name: ITP nuclear transport
is described by: ECO:0000000
fast: false
reactant: MODEL1310110022#
product: MODEL1310110022#

metaR LEUTA
reactant: MODEL1310110022#
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.6.1.42
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
is: SBO:0000176
name: leucine transaminase
type: Reaction
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reversible: true
fast: false
is described by: ECO:0000269

metaM lac L e
name: (S)-lactate
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
initial amount: NaN
is: SBO:0000247
is: CHEBI:16651
boundary condition: false
is: HMDB00190
constant: false
initial concentration: 1.0
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_3f841ab2_bf48_4e6b_957e_74e3ca306f5b
is encoded by: hsa:375056
constant: false
initial amount: NaN
name: MIA3
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: Q5JRA6
type: Species

metaR EX pect LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pectins
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_72fa639b_d1bd_4cd7_9c35_da305746b1c5
is encoded by: hsa:4258
constant: false
is: SBO:0000252
name: MGST2
initial concentration: NaN
boundary condition: true
type: Species
is: D6RBB5
initial amount: NaN
has only substance units: false

metaR S3TASE1ly
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
product: MODEL1310110022#
type: Reaction
name: N-acetylglucosamine-3-sulfatase, lysosomal
is described by: ECO:0000000
fast: false
is: SBO:0000176
reactant: MODEL1310110022#
reversible: true
kinetic law: MODEL1310110022#

metaM hco3 c
boundary condition: false
initial concentration: 1.0
is: C00288
constant: false
type: Species
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: Bicarbonate
is: CHEBI:17544
is: HMDB00595

metaM retinal c
name: retinal
has only substance units: false
type: Species
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
is: HMDB01358
is: SBO:0000247
boundary condition: false
is: CHEBI:15035
initial concentration: 1.0
initial amount: NaN
constant: false

metaR PPItr
kinetic law: MODEL1310110022#
product: MODEL1310110022#
name: Diphosphate transporter, endoplasmic reticulum
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110022#_837b5946_cdf9_4822_9d9c_2c8145757627
name: _AA977580_1_c
is encoded by: hsa:AA977580
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
has only substance units: false
initial amount: NaN

metaR r2375
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110022#
product: MODEL1310110022#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR HMBS
is version of: http://identifiers.org/ec-code/2.5.1.61
name: hydroxymethylbilane synthase
modifier: MODEL1310110022#
type: Reaction
is described by: ECO:0000254
is: SBO:0000176
notes: GENE_ASSOCIATION: (3145.1) SUBSYSTEM: Heme synthesis EC Number: 4.3.1.8 Confidence Level: 2 AUTHORS: PMID:2875434 NOTES:
product: MODEL1310110022#
reversible: false
fast: false
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#

metaM CE2870 c
boundary condition: false
has only substance units: false
name: 3,3'-diiodo-L-thyronine 4'-O-sulfate
is: SBO:0000247
is: HMDB02281
initial concentration: 1.0
is: CHEBI:15374
initial amount: NaN
notes: FORMULA: C15H12I2NO7S CHARGE: -1 INCHI: InChI=1/C15H13I2NO7S/c16-10-5-8(6-12(18)15(19)20)1-3-13(10)24-9-2-4-14(11(17)7-9)25-26(21,22)23/h1-5,7,12H,6,18H2,(H,19,20)(H,21,22,23)/p-1/t12-/m1/s1 EHMN_ABBREVIATION: CE2870
type: Species
constant: false

metaR CYTK1n
is: SBO:0000176
modifier: MODEL1310110022#
name: cytidylate kinase (CMP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
kinetic law: MODEL1310110022#
fast: false
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110022#

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

metaM tcynt c
constant: false
is: HMDB01453
initial concentration: 1.0
has only substance units: false
is: CHEBI:18022
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: thiocyanate

metaR GCC2cm
name: glycine-cleavage complex (lipoamide), mitochondrial
reversible: true
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.8.1.4
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110022#
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.4.2
is version of: http://identifiers.org/ec-code/2.1.2.10
is described by: ECO:0000269
fast: false
product: MODEL1310110022#
kinetic law: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_982ca60f_5185_44e4_a30e_235bd51a82fd
initial concentration: NaN
name: PPCDC
boundary condition: true
is encoded by: hsa:60490
constant: false
has only substance units: false
initial amount: NaN
is: Q96CD2
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_516966b1_5840_411f_8d4a_6605274afb5d
type: Species
initial concentration: NaN
initial amount: NaN
name: _AI539321_1_c
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:AI539321
boundary condition: true

metaR r0838
is described by: ECO:0000000
kinetic law: MODEL1310110022#
name: Free diffusion
type: Reaction
product: MODEL1310110022#
is: SBO:0000185
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
reactant: MODEL1310110022#
fast: false
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.1.2.4
reversible: true

metaM HC01410 m
boundary condition: false
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
name: (2E)-Hexenoyl-CoA
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:28706

http://identifiers.org/biomodels.db/MODEL1310110022#_ccbe3962_4544_488e_914d_49023007ddc9
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:25830
is: Q9BR01
has only substance units: false
type: Species
initial amount: NaN
name: SULT4A1
boundary condition: true

metaM dcacoa m
boundary condition: false
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
is: HMDB06404
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:61430
name: Decanoyl-CoA (n-C10:0CoA)
initial amount: NaN
is: C05274

http://identifiers.org/biomodels.db/MODEL1310110022#_1b233116_4ef8_49e2_b2db_2b25f64dc3d4
name: XDH
is: P47989
constant: false
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:7498

metaM lac L c
type: Species
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB00190
is: CHEBI:16651
name: (S)-lactate
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_0be4840c_f544_4343_98b6_158c6551c5bb
is encoded by: hsa:5631
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
name: PRPS1
is: P60891
type: Species
initial amount: NaN

metaR HSAT2ly
name: heparan-glucosaminide N-acetyltransferase, lysosomal
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
product: MODEL1310110022#
type: Reaction
fast: false
kinetic law: MODEL1310110022#
is described by: ECO:0000000
reversible: false
is: SBO:0000185

metaR EX dhf LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 7,8-Dihydrofolate exchange
type: Reaction

metaR r2374
reactant: MODEL1310110022#
type: Reaction
kinetic law: MODEL1310110022#
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110022#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110022#_d1b86791_f95e_4c1b_9140_93d48f970f8f
has only substance units: false
is encoded by: hsa:6576
type: Species
name: SLC25A1
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: D9HTE9
initial amount: NaN
constant: false

metaM ksii core4 l
initial concentration: 1.0
name: keratan sulfate II (core 4-linked)
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:57614
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
type: Species
initial amount: NaN
is: HMDB00189

metaM 2maacoa m
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
name: 2-methylacetoacetyl-CoA(4-)
type: Species
is: CHEBI:57335
initial concentration: 1.0
is: HMDB01157
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344

http://identifiers.org/biomodels.db/MODEL1310110022#_b94813b2_6093_441a_b141_494e1bbcce00
is: SBO:0000252
initial concentration: NaN
is: A8K0I1
has only substance units: false
initial amount: NaN
type: Species
name: DGKH
constant: false
boundary condition: true
is encoded by: hsa:160851

metaR NDPK4n
is: SBO:0000176
is described by: ECO:0000304
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:dTDP), nuclear
reversible: true
kinetic law: MODEL1310110022#
type: Reaction
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
modifier: MODEL1310110022#
reactant: MODEL1310110022#

metaR DM atp c
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
is described by: ECO:0000134
reversible: false
reactant: MODEL1310110022#
product: MODEL1310110022#
is: SBO:0000176
kinetic law: MODEL1310110022#
type: Reaction
name: DM_atp(c)

metaR EX dcyt LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxycytidine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_7382ccf7_f28c_40cd_9740_fdb353b50ad0
is encoded by: hsa:123041
constant: false
has only substance units: false
name: SLC24A4
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species

metaM ksi l
boundary condition: false
is: HMDB00961
constant: false
has only substance units: false
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
is: SBO:0000247
initial concentration: 1.0
is: C00448
is: CHEBI:175763
name: keratan sulfate I
initial amount: NaN
type: Species

metaR RE2541E
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
reversible: true
product: MODEL1310110022#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.31
is described by: ECO:0000000
name: RE2541
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
fast: false
is: SBO:0000176

metaM CE1926 e
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB00127
is: SBO:0000247
is: CHEBI:15748
type: Species
has only substance units: false
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926
name: gama-carboxyethyl-hydroxychroman
initial amount: NaN

metaR PCHOLPg hs
name: choline phosphatase
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
is described by: ECO:0000269
reactant: MODEL1310110022#
type: Reaction
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
fast: false
product: MODEL1310110022#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.4

http://identifiers.org/biomodels.db/MODEL1310110022#_63500c5c_b577_425e_944e_82243178c1ab
boundary condition: true
has only substance units: false
is encoded by: hsa:R51273
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
name: _R51273_1_c
type: Species

metaR r2373
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110022#
reversible: true
reactant: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_1a4398f8_5d55_4a6c_ad1c_be2abb5b1699
is encoded by: hsa:29922
initial amount: NaN
is: Q9Y5B8
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
name: NME7
constant: false
has only substance units: false

metaR NS26Tg
is described by: ECO:0000000
name: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
reactant: MODEL1310110022#
product: MODEL1310110022#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.99.3
type: Reaction
notes: GENE_ASSOCIATION: (55808.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.3 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#

metaM 10fthf l
name: 10-formyltetrahydrofolate(2-)
boundary condition: false
type: Species
is: HMDB00972
is: CHEBI:57454
is: SBO:0000247
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110022#_a9a1b1d2_1969_41b6_9b09_b121639885a5
initial concentration: NaN
type: Species
is encoded by: hsa:197258
initial amount: NaN
name: FUK
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
is: Q8N0W3

http://identifiers.org/biomodels.db/MODEL1310110022#_0519cb1e_e0d6_451f_b00d_f777a865c5c3
has only substance units: false
is: SBO:0000252
is encoded by: hsa:51727
boundary condition: true
type: Species
initial concentration: NaN
constant: false
name: CMPK1
is: B2R6S5
initial amount: NaN

metaR GALASE19ly
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
modifier: MODEL1310110022#
type: Reaction
fast: false
reversible: false
is: SBO:0000176
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000269
name: beta-galactosidase, lysosomal

metaR RIBt
is described by: ECO:0000000
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
is: SBO:0000185
type: Reaction
reactant: MODEL1310110022#
name: ribose transport via diffusion
fast: false
reversible: true
product: MODEL1310110022#

metaM cit m
has only substance units: false
is: C00158
is: CHEBI:16947
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: HMDB00094
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
name: Citrate

metaM mmcoa R m
boundary condition: false
constant: false
initial concentration: 1.0
name: (R)-methylmalonyl-CoA(5-)
type: Species
is: SBO:0000247
is: CHEBI:57326
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721
is: HMDB01269
initial amount: NaN
has only substance units: false

metaR r2372
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
type: Reaction
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110022#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaM thcholstoic c
is: SBO:0000247
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
type: Species
constant: false
is: HMDB03873
is: CHEBI:18402
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false

metaM CE2839 e
initial amount: NaN
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
type: Species
name: maltodecaose
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5041
boundary condition: false
is: C01936

metaR r0779
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.1.1.35
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110022#
is: SBO:0000176
product: MODEL1310110022#
fast: false

metaR PRO Dtde
type: Reaction
product: MODEL1310110022#
reversible: true
reactant: MODEL1310110022#
is: SBO:0000185
kinetic law: MODEL1310110022#
name: D-proline transport, extracellular
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
is described by: ECO:0000134
fast: false

metaR r0839
fast: false
product: MODEL1310110022#
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.3.1.70
is: SBO:0000185
modifier: MODEL1310110022#
reactant: MODEL1310110022#
reversible: true
name: Postulated transport reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
type: Reaction

metaM pe hs c
constant: false
initial concentration: 1.0
initial amount: NaN
name: phosphatidylethanolamine
boundary condition: false
has only substance units: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:16038
type: Species
is: SBO:0000247

metaR COAtn
fast: false
reactant: MODEL1310110022#
name: coenzyme A transport, nuclear
product: MODEL1310110022#
kinetic law: MODEL1310110022#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaR ASPte
reversible: true
reactant: MODEL1310110022#
product: MODEL1310110022#
kinetic law: MODEL1310110022#
fast: false
name: diffusion of aspartate into blood
is: SBO:0000185
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. no such transporter could be found so diffusion reaction is assumed. NOTES:

metaM hista e
initial concentration: 1.0
is: SBO:0000247
name: histamium
initial amount: NaN
type: Species
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
has only substance units: false
boundary condition: false
is: CHEBI:58432
is: HMDB00870
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_7252c9ad_9cda_45a0_8d28_ae4951018a69
boundary condition: true
has only substance units: false
name: _AI761708_1_m
is: SBO:0000252
is encoded by: hsa:AI761708
initial amount: NaN
initial concentration: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_76379787_523f_4652_89d8_e483ce2e4b88
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:4704
is: Q16795
name: NDUFA9
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_37fe5da7_949c_43fa_a30b_0f2a5066a5a2
name: SLC17A4
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
is: Q9Y2C5
is: SBO:0000252
is encoded by: hsa:10050

metaM hco3 m
has only substance units: false
initial concentration: 1.0
is: HMDB00595
name: Bicarbonate
is: C00288
initial amount: NaN
type: Species
is: CHEBI:17544
boundary condition: false
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
constant: false
is: SBO:0000247

metaR DOLPMT4 Ler
is described by: ECO:0000000
is: SBO:0000185
reversible: false
reactant: MODEL1310110022#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
kinetic law: MODEL1310110022#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110022#

metaM ac c
name: acetate
constant: false
boundary condition: false
type: Species
initial amount: NaN
is: HMDB00042
has only substance units: false
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
is: CHEBI:30089
initial concentration: 1.0
is: SBO:0000247

metaM hs deg7 l
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
type: Species
is: HMDB01352
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17180
name: heparan sulfate, degradation product 7
notes: FORMULA: C67H99N4O80S8 CHARGE: -9

metaR r2378
fast: false
reversible: true
type: Reaction
product: MODEL1310110022#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
is: SBO:0000185

metaR DNDPt36m
is described by: ECO:0000269
type: Reaction
product: MODEL1310110022#
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
kinetic law: MODEL1310110022#
reversible: false
reactant: MODEL1310110022#
modifier: MODEL1310110022#
name: dGDP transport via dCDP antiport

metaR DUTPDPn
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.23
reactant: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: (1854.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.23 Confidence Level: 4 AUTHORS: PMID:12799180,PMID:8631816,PMID:9070952 NOTES:
name: dUTP diphosphatase, nuclear
is described by: ECO:0000269
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
product: MODEL1310110022#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_930cbfb8_87c3_499d_b404_b497ac5213b6
name: GALNT14
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
is: Q96FL9
is encoded by: hsa:79623
type: Species
is: SBO:0000252
has only substance units: false

metaR EX udpgal LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP-D-galactose(2-) exchange
type: Reaction

metaM gdpmann c
constant: false
is: HMDB01163
boundary condition: false
is: CHEBI:57527
initial concentration: 1.0
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
is: SBO:0000247
initial amount: NaN
name: GDP-alpha-D-mannose(2-)
type: Species
has only substance units: false

metaR 10FTHF6GLUtm
fast: false
is: SBO:0000185
kinetic law: MODEL1310110022#
is described by: ECO:0000000
reversible: false
name: 6-glutamyl-10FTHF transport, mitochondrial
reactant: MODEL1310110022#
product: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:mechanism is unknown IT

http://identifiers.org/biomodels.db/MODEL1310110022#_21fcaf01_6b42_456c_a9c0_48ac3c7627c0
is: Q4J699
initial amount: NaN
name: ATP2B2
initial concentration: NaN
is encoded by: hsa:491
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
constant: false

metaR COAtm
is described by: ECO:0000269
reversible: true
name: CoA transporter
product: MODEL1310110022#
fast: false
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only

metaR GGH 7THFe
is described by: ECO:0000000
reversible: false
name: Gamma-glutamyl hydrolase (7THF), extracellular
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.4.19.9
reactant: MODEL1310110022#
modifier: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is: SBO:0000176
product: MODEL1310110022#
type: Reaction

metaM prostgd2 c
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:57406
initial amount: NaN
name: prostaglandin D2(1-)
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: HMDB01403
type: Species

metaR PPItm
is described by: ECO:0000134
reversible: true
kinetic law: MODEL1310110022#
fast: false
product: MODEL1310110022#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
type: Reaction
name: diphopshate transporter, mitochondrial
reactant: MODEL1310110022#

metaM mag hs e
is: SBO:0000247
name: monoacylglycerol 2
initial concentration: 1.0
is: CHEBI:15603
constant: false
type: Species
has only substance units: false
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
boundary condition: false
initial amount: NaN
is: HMDB00687

metaR PGMT
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (5236.1) or (55276.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.4.2.2 Confidence Level: 0 AUTHORS: PMID:4829444 NOTES:
product: MODEL1310110022#
reversible: true
fast: false
is described by: ECO:0000134
is: SBO:0000176
name: phosphoglucomutase
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/5.4.2.2
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_4408c832_ecf0_4d8a_8fe0_232786406514
initial concentration: NaN
boundary condition: true
is encoded by: hsa:216
is: P00352
type: Species
initial amount: NaN
has only substance units: false
name: ALDH1A1
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_8a0d96e9_9641_41bc_9c78_a6852562eac5
name: SLC7A9
has only substance units: false
is encoded by: hsa:11136
is: SBO:0000252
type: Species
initial amount: NaN
is: P82251
initial concentration: NaN
boundary condition: true
constant: false

metaR r2379
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
fast: false
kinetic law: MODEL1310110022#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110022#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_d928c34f_2054_4f89_8b9a_562a30277920
initial amount: NaN
name: SUCLG1:SUCLA2
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
has part: E5KS60
is encoded by: hsa:8803
constant: false
is: SBO:0000297

metaM hmgcoa c
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
constant: false
is: HMDB01375
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: Hydroxymethylglutaryl-CoA
is: SBO:0000247
is: CHEBI:15467

metaR r1930
is described by: ECO:0000000
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
reactant: MODEL1310110022#
name: Y+LAT2 Utilized transport
fast: false
product: MODEL1310110022#

metaR r0834
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
fast: false
type: Reaction
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is: SBO:0000185
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
modifier: MODEL1310110022#
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.5.4.16

metaR 4MOPte
name: Transport of 4-methyl-2-oxopentanoate
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
reversible: true
product: MODEL1310110022#
is: SBO:0000185
is described by: ECO:0000134
fast: false
type: Reaction

metaR 4ABUTtcn
reactant: MODEL1310110022#
type: Reaction
name: transport of GABA
is described by: ECO:0000134
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: Jane D. Carver, W. Allan Walkera , The Journal of Nutritional Biochemistry, Volume 6, Issue 2, February 1995, Pages 58?72. NOTES:added during gap-filling, required for GABA role in cell proliferation.
kinetic law: MODEL1310110022#
fast: false
is: SBO:0000185
product: MODEL1310110022#

metaR C3STDH1r
reversible: false
fast: false
modifier: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000176
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER version NJ
is described by: ECO:0000134
kinetic law: MODEL1310110022#
name: C-3 sterol dehydrogenase (4-methylzymosterol)
type: Reaction
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.1.1.170

metaM 4abutn e
type: Species
name: 4-ammoniobutanal
is: CHEBI:58264
constant: false
is: HMDB01080
initial amount: NaN
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247

metaM ala B e
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
initial concentration: 1.0
type: Species
is: CHEBI:16958
boundary condition: false
constant: false
has only substance units: false
is: HMDB00056
name: beta-alanine
is: SBO:0000247
initial amount: NaN

metaR r0083
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.1.1.42
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
product: MODEL1310110022#
fast: false
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:

metaR r0002
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000185
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
name: Active transport

http://identifiers.org/biomodels.db/MODEL1310110022#_59302d21_a3a9_4a28_8e8f_cb869747f7c5
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
is: B1AM93
boundary condition: true
has only substance units: false
is encoded by: hsa:4702
name: NDUFA8

http://identifiers.org/biomodels.db/MODEL1310110022#_4d0b65fe_f886_4d54_b0e6_e1f6ef7122ae
has only substance units: false
is: SBO:0000252
is: A0S0A7
name: NOS3
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:4846
boundary condition: true
initial concentration: NaN

metaR DCMPDA
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
fast: false
is: SBO:0000176
modifier: MODEL1310110022#
type: Reaction
is described by: ECO:0000254
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
name: dCMP deaminase
is version of: http://identifiers.org/ec-code/3.5.4.12
reversible: true
product: MODEL1310110022#

metaM nh4 e
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: SBO:0000247
boundary condition: false
is: CHEBI:28938
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: HMDB00051
name: ammonium
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110022#_934d272f_cf37_4350_90ff_646bf818c613
has only substance units: false
name: BDH1
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q02338
is encoded by: hsa:622
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_1555a632_8af2_4ded_bf36_9467fbe4163c
constant: false
initial amount: NaN
is encoded by: hsa:217
name: ALDH2
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
is: P05091
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_1c73f28d_217d_4178_a31e_3adcd82d282d
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
name: TXNRD1
is: SBO:0000252
type: Species
is encoded by: hsa:7296
is: Q16881

metaM fe2 m
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
is: HMDB00692
is: CHEBI:29033
has only substance units: false
initial amount: NaN
name: Fe2+
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
is: C00023

http://identifiers.org/biomodels.db/MODEL1310110022#_fda0c401_7f25_4bce_a552_a9a18b167ee1
name: ALDH1A3
type: Species
constant: false
is: SBO:0000252
is: P47895
boundary condition: true
initial concentration: NaN
is encoded by: hsa:220
has only substance units: false
initial amount: NaN

metaR r1933
type: Reaction
modifier: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110022#
fast: false
is: SBO:0000185
reversible: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport

metaM hs deg20 l
has only substance units: false
initial concentration: 1.0
is: HMDB00127
boundary condition: false
type: Species
constant: false
is: CHEBI:15748
initial amount: NaN
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
is: SBO:0000247
name: heparan sulfate, degradation product 20

metaR HMGCOASim
reversible: false
is version of: http://identifiers.org/ec-code/2.3.3.10
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
product: MODEL1310110022#
modifier: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000269
kinetic law: MODEL1310110022#
name: Hydroxymethylglutaryl CoA synthase (ir)
is: SBO:0000176
fast: false
type: Reaction

metaR r2376
reactant: MODEL1310110022#
is: SBO:0000185
fast: false
reversible: true
product: MODEL1310110022#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110022#

metaR ITCOAL1m
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
is described by: ECO:0000304
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/6.2.1.4
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
reversible: true
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110022#
kinetic law: MODEL1310110022#

metaR r0082
is: SBO:0000176
reversible: true
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.2
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (2875.1) or (84706.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_40335d85_e7ef_4a45_8aa0_676620d93711
is: SBO:0000252
initial concentration: NaN
name: FOLR3
is encoded by: hsa:2352
boundary condition: true
initial amount: NaN
has only substance units: false
is: Q05C14
constant: false
type: Species

metaR DHCR243r
reversible: false
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
is described by: ECO:0000134
fast: false
product: MODEL1310110022#
modifier: MODEL1310110022#
name: 24-dehydrocholesterol reductase [Precursor]
is version of: http://identifiers.org/ec-code/1.3.1.72
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000176
type: Reaction

metaR DOCOSACTDr
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of docosanoic acid by diffusion
type: Reaction

metaR GLYtp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:TDV
is: SBO:0000185
fast: false
is described by: ECO:0000000
type: Reaction
name: glycine passive transport to peroxisome
product: MODEL1310110022#
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
reversible: true

metaM prostgd2 e
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:57406
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: HMDB01403
name: prostaglandin D2(1-)

http://identifiers.org/biomodels.db/MODEL1310110022#_724271d3_eb48_401b_90b8_5a4ca881ad9c
boundary condition: true
is: Q6ZWP6
is encoded by: hsa:27034
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: ACAD8
type: Species
constant: false
has only substance units: false

metaR r0836
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.16
is: SBO:0000185
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
fast: false
modifier: MODEL1310110022#
reversible: true
product: MODEL1310110022#
is described by: ECO:0000000
reactant: MODEL1310110022#

metaR NH4tp
fast: false
is described by: ECO:0000000
name: ammonia peroxisomal transport
is: SBO:0000185
reversible: true
product: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#

metaR GALASE8ly
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
name: beta-galactosidase, lysosomal
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110022#
reversible: false
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110022#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18

metaR PROGLYPRO1c
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: hydrolysis of glycylproline in the small intestine for cellular uptake
type: Reaction

metaR r2377
product: MODEL1310110022#
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

metaR PROGLYPEPT1tc
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Prolylglycine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaR r0360
fast: false
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/6.2.1.16
is: SBO:0000176
reactant: MODEL1310110022#
reversible: false
type: Reaction
product: MODEL1310110022#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
kinetic law: MODEL1310110022#

metaM ala B c
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
is: HMDB00056
name: beta-alanine
type: Species
is: SBO:0000247
is: CHEBI:16958
boundary condition: false
has only substance units: false

metaR GGH 10FTHF5GLUl
is version of: http://identifiers.org/ec-code/3.4.19.9
modifier: MODEL1310110022#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110022#
product: MODEL1310110022#
fast: false
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
type: Reaction
reversible: false
name: Gamma-glutamyl hydrolase (10FTHF5GLU), lysosomal

metaR r0672
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.65
reversible: true
is described by: ECO:0000000
fast: false
modifier: MODEL1310110022#
name: Cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase Bile acid biosynthesis EC:1.1.1.181
type: Reaction
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.181 Confidence Level: 0 AUTHORS: PMID:12679481 NOTES:

metaR 10FTHF6GLUtl
reversible: false
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:carrier-mediated transport - but which and how is unknown IT
product: MODEL1310110022#
name: 6-glutamyl-10FTHF transport, lysosomal
is described by: ECO:0000000
fast: false
is: SBO:0000185
kinetic law: MODEL1310110022#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_b7cbc91a_f5fb_47a1_a2cc_8f72b1b35bbc
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:10797
is: SBO:0000252
type: Species
is: P13995
has only substance units: false
constant: false
name: MTHFD2

metaR r2525
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110022#
is: SBO:0000185
reactant: MODEL1310110022#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

metaM 4abutn c
notes: FORMULA: C4H10NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:58264
initial concentration: 1.0
is: SBO:0000247
is: HMDB01080
constant: false
name: 4-Aminobutanal
is: C00555

metaR PPBNGS
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/4.2.1.24
is described by: ECO:0000269
product: MODEL1310110022#
fast: false
name: porphobilinogen synthase
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (210.1) or (210.2) SUBSYSTEM: Heme synthesis EC Number: 4.2.1.24 Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
type: Reaction
reversible: false

metaM hs deg12 l
initial concentration: 1.0
notes: FORMULA: C55H82N3O64S6 CHARGE: -7
is: SBO:0000247
is: CHEBI:17180
type: Species
is: HMDB01352
initial amount: NaN
has only substance units: false
name: heparan sulfate, degradation product 12
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_7b162877_a113_435e_a9b8_5e41d3261771
is: SBO:0000252
is: P11169
name: SLC2A3
boundary condition: true
is encoded by: hsa:6515
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
constant: false

metaR RETHe
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
kinetic law: MODEL1310110022#
name: retinyl ester hydrolase, extracellular
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110022#
fast: false
product: MODEL1310110022#
type: Reaction
reversible: false

metaR DPCOAPPe
is: SBO:0000176
product: MODEL1310110022#
reactant: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: Confidence Level: AUTHORS: NOTES:
reversible: false
name: Pyrophasphatase (dephospho-CoA, extracellular)
kinetic law: MODEL1310110022#
is described by: ECO:0000134
type: Reaction

metaM hLkynr c
boundary condition: false
is: CHEBI:17380
name: 3-hydroxy-L-kynurenine
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB11631
initial amount: NaN
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227

metaR COAtr
kinetic law: MODEL1310110022#
is: SBO:0000185
reversible: true
name: COA transporter, endoplasmic reticulum
is described by: ECO:0000000
fast: false
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
product: MODEL1310110022#
type: Reaction

metaR S23Tg
reactant: MODEL1310110022#
modifier: MODEL1310110022#
fast: false
name: beta-galactoside alpha-2,3-sialyltransferase (T antigen)
type: Reaction
notes: GENE_ASSOCIATION: (6482.1) or (6482.2) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:8027041 NOTES:NCD
is: SBO:0000176
product: MODEL1310110022#
reversible: false
kinetic law: MODEL1310110022#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.99.4

metaR IDPtn
fast: false
reversible: true
kinetic law: MODEL1310110022#
name: IDP nuclear transport
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
product: MODEL1310110022#
reactant: MODEL1310110022#

metaM nh4 c
is: SBO:0000247
has only substance units: false
is: CHEBI:28938
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: C01342
initial concentration: 1.0
initial amount: NaN
is: HMDB00051
name: Ammonium
constant: false
type: Species
boundary condition: false

metaR GALASE15ly
is: SBO:0000176
name: beta-galactosidase, lysosomal
product: MODEL1310110022#
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
type: Reaction
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaR ACNAMlt
kinetic law: MODEL1310110022#
name: N-acetylneuraminate transport into lysososme
is: SBO:0000185
modifier: MODEL1310110022#
type: Reaction
product: MODEL1310110022#
is described by: ECO:0000269
reversible: true
fast: false
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ

metaM 2mb2coa m
is: HMDB02054
initial concentration: 1.0
is: CHEBI:57337
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
name: 2-methylcrotonoyl-CoA(4-)
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_46220b5d_62d6_465c_93d8_08e2fa9d0cf6
is encoded by: hsa:6578
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
is: Q92959
constant: false
name: SLCO2A1
has only substance units: false

metaM pep c
initial amount: NaN
constant: false
boundary condition: false
name: Phosphoenolpyruvate
is: SBO:0000247
type: Species
is: C00074
is: CHEBI:18021
has only substance units: false
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
is: HMDB00263
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110022#_74dc1578_764d_43a9_8ba7_9e146e57a0aa
name: _728226_1_e
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:728226

metaM ksi deg10 l
is: HMDB01354
initial concentration: 1.0
is: CHEBI:57455
notes: FORMULA: C188H302N13O163S9 CHARGE: -9
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
name: keratan sulfate I, degradation product 10

metaR r0781
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.13.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
reactant: MODEL1310110022#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
modifier: MODEL1310110022#
name: Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) Biosynthesis of steroids EC:1.14.13.70
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110022#_73b0582f_1793_4a79_8a6c_8e400cbeb74e
is: O95498
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:8875
name: VNN2

metaR r0830
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110022#
product: MODEL1310110022#
reversible: true
modifier: MODEL1310110022#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.5.4.16
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
fast: false
kinetic law: MODEL1310110022#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2

http://identifiers.org/biomodels.db/MODEL1310110022#_8809a05d_153a_4f72_be36_fb833b424e66
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: P48735
boundary condition: true
constant: false
name: IDH2
initial concentration: NaN
type: Species
is encoded by: hsa:3418

metaM fmn e
is: SBO:0000247
name: FMN
boundary condition: false
is: HMDB01520
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C17H19N4O9P CHARGE: -2
constant: false
is: C00061
is: CHEBI:58210
type: Species
initial amount: NaN

metaR D LACt2
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
is described by: ECO:0000269
kinetic law: MODEL1310110022#
product: MODEL1310110022#
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110022#
fast: false
modifier: MODEL1310110022#
name: D-lactate transport via proton symport

http://identifiers.org/biomodels.db/MODEL1310110022#_695e6864_254d_41c8_9af5_cb0b16aa53f0
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: GPT
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:2875
is: P24298
boundary condition: true

metaR C3STDH1Pr
modifier: MODEL1310110022#
name: C-3 sterol dehydrogenase (4-methylzymosterol)
type: Reaction
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.1.1.170
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10710235,PMID:14506130 NOTES:NCD ER version NJ
product: MODEL1310110022#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110022#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110022#_e9035136_72cd_41eb_a4a4_9f2973bf55d7
name: RPE
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
boundary condition: true
is encoded by: hsa:6120
is: Q96AT9
has only substance units: false

metaR DGULND
is described by: ECO:0000000
product: MODEL1310110022#
type: Reaction
reversible: true
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
name: dehydro-L-gulonate decarboxylase

metaR EX acmana LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-acetyl-D-mannosamine
type: Reaction

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

metaR r0670
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
reversible: false
is described by: ECO:0000000
product: MODEL1310110022#
fast: false
type: Reaction
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
name: (S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4

http://identifiers.org/biomodels.db/MODEL1310110022#_1bf07567_f792_4ea4_80c6_e7a71f52791d
type: Species
initial amount: NaN
is: SBO:0000252
name: ACADVL
has only substance units: false
is encoded by: hsa:37
constant: false
boundary condition: true
initial concentration: NaN
is: P49748

metaM ac e
is: HMDB00042
has only substance units: false
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
name: acetate
constant: false
initial amount: NaN
type: Species
is: CHEBI:30089
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaM pail5p hs n
boundary condition: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:57795
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)

metaM thf m
is: CHEBI:57453
boundary condition: false
name: 5,6,7,8-Tetrahydrofolate
has only substance units: false
is: SBO:0000247
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
is: HMDB01846
is: C00101
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0

metaR r2520
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418 NOTES:
product: MODEL1310110022#
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.1
reactant: MODEL1310110022#
type: Reaction
kinetic law: MODEL1310110022#

metaR CHAT
reactant: MODEL1310110022#
is: SBO:0000176
fast: false
modifier: MODEL1310110022#
is described by: ECO:0000269
type: Reaction
reversible: true
name: Choline O-acetyltransferase
is version of: http://identifiers.org/ec-code/2.3.1.6
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
product: MODEL1310110022#
kinetic law: MODEL1310110022#

metaM cit e
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
name: citrate(3-)
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:16947
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
is: HMDB00094

metaR COAtp
kinetic law: MODEL1310110022#
name: coenzyme A transport, peroxisomal
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110022#
type: Reaction

metaM hista c
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
type: Species
is: CHEBI:58432
is: HMDB00870
initial concentration: 1.0
name: histamium

http://identifiers.org/biomodels.db/MODEL1310110022#_90e875e0_3c33_4835_81f8_f9b97cff36d3
initial concentration: NaN
is: P00568
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:203
boundary condition: true
name: AK1
initial amount: NaN
has only substance units: false

metaR CYTK8
is described by: ECO:0000269
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
type: Reaction
reversible: true
modifier: MODEL1310110022#
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (CMP,dATP)
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176

metaM ptth c
is: HMDB03426
is: CHEBI:16753
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
constant: false
has only substance units: false
name: pantetheine
type: Species
boundary condition: false

metaM pe hs e
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:16038
initial concentration: 1.0
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
type: Species
name: phosphatidylethanolamine
boundary condition: false

metaM retn c
has only substance units: false
constant: false
is: CHEBI:35291
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
initial concentration: 1.0
name: all-trans-retinoate
is: HMDB01852
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false

metaR OXAtp
is: SBO:0000185
type: Reaction
name: oxalate transport out of peroxisome
is described by: ECO:0000000
product: MODEL1310110022#
fast: false
reversible: false
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
reactant: MODEL1310110022#

metaR INSTt4
reversible: true
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000269
modifier: MODEL1310110022#
name: inositol transport via sodium symport
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD

metaR FPGS8m
name: folylpolyglutamate synthetase (10fthf), mitochondrial
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/6.3.2.17
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT
kinetic law: MODEL1310110022#
is: SBO:0000176
modifier: MODEL1310110022#
is described by: ECO:0000000
fast: false
reversible: false
type: Reaction
reactant: MODEL1310110022#

metaR r0086
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
product: MODEL1310110022#
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.5.1.3
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
modifier: MODEL1310110022#
reversible: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
fast: false

metaR r0783
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
fast: false
is described by: ECO:0000000
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
modifier: MODEL1310110022#
product: MODEL1310110022#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110022#
is: SBO:0000176
kinetic law: MODEL1310110022#

metaM ascb L e
boundary condition: false
is: HMDB00044
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
has only substance units: false
name: L-ascorbate
is: CHEBI:38290
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_bbcb66d6_fd5d_412d_aaa6_1d6968ab17e0
constant: false
is encoded by: hsa:NM 001929
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
name: _NM_001929_1_c
is: SBO:0000252

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaR CYTDt
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
reversible: true
fast: false
name: cytidine facilated transport in cytosol
product: MODEL1310110022#
is: SBO:0000185
reactant: MODEL1310110022#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#

metaR GLCMter
reversible: false
product: MODEL1310110022#
is: SBO:0000185
name: glucose transport via membrane vesicle
fast: false
is described by: ECO:0000000
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11882499 NOTES:NCD

metaM oxa e
type: Species
is: HMDB02329
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
name: oxalate(2-)
is: SBO:0000247
is: CHEBI:30623
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaR SMPD3g
is: SBO:0000176
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (55512.1) or (55512.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/3.1.4.12
type: Reaction
modifier: MODEL1310110022#
name: sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
fast: false
reversible: false
product: MODEL1310110022#
kinetic law: MODEL1310110022#
is described by: ECO:0000304

metaR EX retinol LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinol exchange
type: Reaction

metaR r2521
kinetic law: MODEL1310110022#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
product: MODEL1310110022#
type: Reaction
fast: false
is: SBO:0000185
name: Utilized transport
reactant: MODEL1310110022#
reversible: true

metaM coa x
constant: false
is: SBO:0000247
is: C00010
name: Coenzyme A
type: Species
is: CHEBI:57287
initial concentration: 1.0
is: HMDB01423
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
boundary condition: false
initial amount: NaN
has only substance units: false

metaR CYTK9
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
modifier: MODEL1310110022#
is described by: ECO:0000269
name: cytidylate kinase (CMP,dCTP)
kinetic law: MODEL1310110022#
is: SBO:0000176
reactant: MODEL1310110022#

metaM mag hs c
initial amount: NaN
is: CHEBI:16987
is: HMDB12130
is: SBO:0000247
has only substance units: false
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
constant: false
boundary condition: false
name: monoacylglycerol 2
type: Species

metaR r1819
kinetic law: MODEL1310110022#
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110022#
name: Y+LAT2 Utilized transport
is: SBO:0000185
fast: false
reactant: MODEL1310110022#
reversible: false

metaR GLCter
is: SBO:0000185
product: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD
is described by: ECO:0000000
type: Reaction
name: glucose transport, endoplasmic reticulum
kinetic law: MODEL1310110022#
reversible: true
reactant: MODEL1310110022#

metaR r1464
product: MODEL1310110022#
is described by: ECO:0000000
name: Active transport
kinetic law: MODEL1310110022#
is: SBO:0000185
fast: false
reversible: true
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_c8f74d49_804e_4633_8364_11794744f24f
name: SDHA
is encoded by: hsa:6389
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
is: P31040

metaR r0085
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.42
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
reversible: false
fast: false
product: MODEL1310110022#
reactant: MODEL1310110022#

metaR DMATTx
kinetic law: MODEL1310110022#
is described by: ECO:0000134
reactant: MODEL1310110022#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.5.1.1
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
modifier: MODEL1310110022#
name: dimethylallyltranstransferase
is: SBO:0000176
fast: false
product: MODEL1310110022#

metaR GLYtm
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
name: glycine passive transport to mitochondria
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
is described by: ECO:0000000
type: Reaction

metaR r1684
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
reactant: MODEL1310110022#
name: Y+LAT2 Utilized transport
fast: false
product: MODEL1310110022#
type: Reaction
is: SBO:0000185

metaR r0782
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 1.1.1.271 Confidence Level: 0 AUTHORS: PMID:10410995,PMID:2428310,PMID:9603974 NOTES:
name: GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing) Fructose and mannose metabolism EC:1.1.1.271
is described by: ECO:0000000
reversible: false
product: MODEL1310110022#
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
type: Reaction
fast: false

metaR DHPR
is version of: http://identifiers.org/ec-code/1.5.1.34
is: SBO:0000176
type: Reaction
reversible: false
fast: false
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.6.99.7 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110022#
name: 6,7-dihydropteridine reductase
kinetic law: MODEL1310110022#
product: MODEL1310110022#

metaR r0560
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
is: SBO:0000176
product: MODEL1310110022#
fast: false
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
type: Reaction

metaR r2097
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
is: SBO:0000185
product: MODEL1310110022#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_22a61049_ccd3_4d83_aef6_7718b4ed2d46
is: P00558
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5230
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
name: PGK1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_ec0f9623_39da_46d2_aa4d_d79a59d0dba7
name: SLC27A1
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:376497
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_f7de6929_932f_4ff8_a828_3902014082b3
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
type: Species
name: TXNRD1
is encoded by: hsa:7296
is: SBO:0000252

metaM cpppg3 c
is: C03263
is: HMDB01261
constant: false
notes: FORMULA: C36H40N4O8 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01085 EHMN_ABBREVIATION: C03263
type: Species
name: Coproporphyrinogen III
initial concentration: 1.0
boundary condition: false
is: CHEBI:57309
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaM retn e
initial amount: NaN
is: CHEBI:35291
name: all-trans-retinoate
has only substance units: false
is: HMDB01852
is: SBO:0000247
constant: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
boundary condition: false
initial concentration: 1.0
type: Species

metaM fe2 c
name: Fe2+
type: Species
is: C00023
is: HMDB00692
is: CHEBI:29033
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaR NACHEXA21ly
type: Reaction
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is described by: ECO:0000000
reversible: false
product: MODEL1310110022#
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase A, lysosomal

metaR CBASPte
is described by: ECO:0000134
fast: false
type: Reaction
name: Transport of N-carbamoyl-L-aspartate
is: SBO:0000185
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110022#

metaM coa r
boundary condition: false
is: C00010
initial concentration: 1.0
is: SBO:0000247
name: Coenzyme A
is: CHEBI:57287
type: Species
is: HMDB01423
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
initial amount: NaN
constant: false
has only substance units: false

metaR CYTK6
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110022#
reversible: true
product: MODEL1310110022#
name: cytidylate kinase (CMP,CTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000176
fast: false

metaM cit c
constant: false
is: CHEBI:16947
has only substance units: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB00094
is: C00158
is: SBO:0000247
boundary condition: false
name: Citrate

http://identifiers.org/biomodels.db/MODEL1310110022#_22eed24e_8cf0_4208_8e7c_100dadf4c56c
is: SBO:0000252
is encoded by: hsa:765
is: Q5FC00
initial amount: NaN
type: Species
name: CA6
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR C4STMO2r
modifier: MODEL1310110022#
type: Reaction
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (6307.1) or (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.1.1.170
fast: false
name: C-4 methyl sterol oxidase
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.14.13.72
reversible: false

metaR DM T antigen g
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: DM T antigen(g)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_67a74211_77f2_4b05_9aee_eef83381abb9
boundary condition: true
constant: false
is: Q9BXS1
is encoded by: hsa:91734
type: Species
has only substance units: false
name: IDI2
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaM ksi deg5 l
is: CHEBI:12936
constant: false
has only substance units: false
initial amount: NaN
is: HMDB00143
initial concentration: 1.0
name: keratan sulfate I, degradation product 5
type: Species
boundary condition: false
notes: FORMULA: C222H356N15O194S11 CHARGE: -11
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110022#_dcf2dbfb_2041_4cf4_adf8_d9ee6e84a3a0
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:80025
type: Species
is: Q9BZ23
name: PANK2
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR URAt
fast: false
name: uracil transport via facilated diffusion
is: SBO:0000185
product: MODEL1310110022#
is described by: ECO:0000269
kinetic law: MODEL1310110022#
type: Reaction
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
reversible: true
modifier: MODEL1310110022#

metaM dcamp c
constant: false
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
is: HMDB00536
name: N6-(1,2-Dicarboxyethyl)-AMP
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:57567
is: C03794
boundary condition: false
type: Species

metaR PGK
is version of: http://identifiers.org/ec-code/2.7.2.3
modifier: MODEL1310110022#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110022#
reversible: true
type: Reaction
product: MODEL1310110022#
name: phosphoglycerate kinase
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (5230.1) or (375056.1) or (5232.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110022#

metaR r2098
is described by: ECO:0000000
product: MODEL1310110022#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110022#
reactant: MODEL1310110022#
type: Reaction
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110022#

metaR SADT
kinetic law: MODEL1310110022#
name: sulfate adenylyltransferase
reactant: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
product: MODEL1310110022#
reversible: false
fast: false
modifier: MODEL1310110022#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.25
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110022#_583d7f2f_5310_4c60_8a41_cc0f21663c17
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2686
is: A0PJJ9
boundary condition: true
name: GGT7
constant: false
initial concentration: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_437b817b_7c83_4665_9faa_3439196f1fd4
name: SLCO3A1
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
is: Q9UIG8
is encoded by: hsa:28232

metaM udp c
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00295
constant: false
has only substance units: false
is: CHEBI:58223
is: C00015
name: UDP

metaM HC02217 c
type: Species
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
is: CHEBI:27647
initial concentration: 1.0
name: prostaglandin-g2
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR BAMPPALDOX
notes: GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.36 Confidence Level: 1 AUTHORS: PMID:12586697 NOTES:SAB
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.2.1.36
modifier: MODEL1310110022#
fast: false
product: MODEL1310110022#
is: SBO:0000176
is described by: ECO:0000212
reversible: false
type: Reaction
name: beta-Aminopropion aldehyde:NAD+ oxidoreductase
is version of: http://identifiers.org/ec-code/1.2.1.3

metaM CE4876 r
is: CHEBI:12947
initial amount: NaN
name: delta12-Prostaglandin J2
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876

metaM xan x
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
name: Xanthine
initial concentration: 1.0
is: CHEBI:17712
is: C00385
is: HMDB00292
initial amount: NaN
type: Species

metaM cgly c
is: HMDB00078
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
type: Species
name: L-cysteinylglycine
constant: false
is: CHEBI:4047

metaM pi g
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial amount: NaN
is: HMDB00973
type: Species
is: SBO:0000247
is: CHEBI:43474
boundary condition: false
constant: false
has only substance units: false
name: hydrogenphosphate
initial concentration: 1.0

metaR CITtam
product: MODEL1310110022#
reactant: MODEL1310110022#
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
name: citrate transport, mitochondrial
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
reversible: true
is described by: ECO:0000269

metaM xtsn c
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
is: CHEBI:18107
constant: false
name: xanthosine
type: Species
is: HMDB00299
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110022#_1731cceb_66fb_4170_882c_72b252cba8ff
is: P46721
is encoded by: hsa:6579
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
name: SLCO1A2

metaR CYTK7
reactant: MODEL1310110022#
type: Reaction
reversible: true
fast: false
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110022#
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP,UTP)

metaM L2aadp m
initial concentration: 1.0
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
type: Species
is: SBO:0000247
name: L-2-aminoadipate(1-)
is: CHEBI:58672
has only substance units: false
is: HMDB00510
initial amount: NaN
boundary condition: false
constant: false

metaM pail34p hs c
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:57658
type: Species
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
initial concentration: 1.0

metaR r0226
is: SBO:0000176
product: MODEL1310110022#
modifier: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:6882460,PMID:962851 NOTES:
type: Reaction
name: 5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110022#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110022#_3b7c87fd_9ca3_48e8_85e4_1c6a2be0a931
boundary condition: true
is: P36969
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
has only substance units: false
name: GPX4
is encoded by: hsa:2879
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_8a4af62a_eca6_49f1_982f_c3f33a91b04e
boundary condition: true
initial amount: NaN
name: UROD
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:7389
is: P06132
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_3952b535_f1f3_4cdb_9f9c_fcb8baf4fb2d
initial amount: NaN
is encoded by: hsa:124637
is: SBO:0000252
initial concentration: NaN
constant: false
name: CYB5D1
has only substance units: false
type: Species
is: Q6P9G0
boundary condition: true

metaR 2OXOADOXm
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.4
product: MODEL1310110022#
type: Reaction
is described by: ECO:0000304
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) (mitochondria)
is version of: http://identifiers.org/ec-code/1.2.4.2
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.3.1.61
reversible: false
notes: GENE_ASSOCIATION: (4967.1) and (1738.1 and 8050.1) and (1743.1) or (4967.2) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Lysine metabolism EC Number: 2.3.1.61 Confidence Level: 2 AUTHORS: NOTES:SAB
fast: false
modifier: MODEL1310110022#

metaR r0892
name: Facilitated diffusion
is version of: http://identifiers.org/ec-code/3.1.2.27
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110022#
modifier: MODEL1310110022#
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110022#_ad72b111_29b6_4860_89c8_3b8c1d6350d4
constant: false
has only substance units: false
initial concentration: NaN
name: _AA532636_1_m
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:AA532636
type: Species

metaM oaa c
name: Oxaloacetate
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB00223
notes: FORMULA: C4H2O5 CHARGE: -2
is: CHEBI:3338
boundary condition: false
has only substance units: false
is: C00036
is: SBO:0000247
constant: false

metaR r2099
fast: false
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110022#
modifier: MODEL1310110022#
type: Reaction
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reactant: MODEL1310110022#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110022#_da1e9246_0747_4e17_a8f5_3c87c17b97f1
constant: false
is: H0UI06
initial amount: NaN
is encoded by: hsa:1347
has only substance units: false
name: COX7A2
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true

metaM e4p c
is: CHEBI:16897
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB01321
type: Species
initial concentration: 1.0
is: C00279
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
constant: false
boundary condition: false
name: D-Erythrose 4-phosphate

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

metaM thp2c c
is: HMDB12130
name: 1-piperideine-6-carboxylate
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:16987
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450

http://identifiers.org/biomodels.db/MODEL1310110022#_eb1ee8a6_5a56_44b2_baf6_1ac95f728556
is: P32320
is encoded by: hsa:978
has only substance units: false
type: Species
name: CDA
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR GGH 10FTHF5GLUe
product: MODEL1310110022#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110022#
reversible: false
is version of: http://identifiers.org/ec-code/3.4.19.9
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
type: Reaction
modifier: MODEL1310110022#
reactant: MODEL1310110022#
name: Gamma-glutamyl hydrolase (10FTHF5GLU), extracellular
fast: false

metaR SIAASE2ly
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110022#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110022#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110022#
product: MODEL1310110022#
fast: false
name: sialidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaR CYTK4
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
name: cytidylate kinase (dCMP)(GTP)
is version of: http://identifiers.org/ec-code/2.7.4.3
product: MODEL1310110022#
reactant: MODEL1310110022#
type: Reaction
fast: false
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
reversible: true

metaR MALTSULtm
modifier: MODEL1310110022#
is: SBO:0000185
fast: false
name: Malate:thiosulfate antiport, mitochondrial
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is described by: ECO:0000269
product: MODEL1310110022#
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
type: Reaction
reversible: true

metaR EX retn LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinoate exchange
type: Reaction

metaR INSt
is: SBO:0000185
name: Inosine transport (diffusion)
reactant: MODEL1310110022#
reversible: true
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:AR
is described by: ECO:0000269
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110022#_77fa56c5_fb5b_4e9c_9458_9081bf03fd1c
has only substance units: false
name: EHHADH
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:1962
initial concentration: NaN
boundary condition: true
is: Q9NY65

metaM HC01434 m
initial amount: NaN
is: CHEBI:58931
constant: false
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: oxalatosuccinate(3-)
has only substance units: false

metaR RE1807C
type: Reaction
product: MODEL1310110022#
kinetic law: MODEL1310110022#
name: RE1807
is: SBO:0000176
fast: false
reactant: MODEL1310110022#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:

metaM nh4 m
is: C01342
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28938
boundary condition: false
is: HMDB00051
name: Ammonium
has only substance units: false
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_0aca2725_365c_4871_9d85_a62e0f36fc2e
name: GALNT8
type: Species
initial amount: NaN
is: Q9NY28
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:26290

metaR r0940
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110022#
product: MODEL1310110022#
reversible: true
name: Free diffusion
fast: false
kinetic law: MODEL1310110022#
is: SBO:0000185
is described by: ECO:0000000

metaR 3HBCOAHLm
is: SBO:0000176
product: MODEL1310110022#
type: Reaction
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
reversible: false
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM

metaR r0437
is version of: http://identifiers.org/ec-code/4.1.2.13
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
reactant: MODEL1310110022#
fast: false
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
reversible: true
is: SBO:0000176
product: MODEL1310110022#
is described by: ECO:0000000

metaR ALOX5
modifier: MODEL1310110022#
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
type: Reaction
product: MODEL1310110022#
fast: false
is version of: http://identifiers.org/ec-code/1.13.11.34
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:2829172 NOTES:cofactors + usage still not clear see version ALOX5b for ATP concomittant hydrolysis - literature notes in vitro requirement for Ca and ATP for activity in addition to Fe
reversible: false
is: SBO:0000176
name: Arachidonate 5-lipoxygenase

metaM sbt D e
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
name: D-glucitol
constant: false
is: HMDB00247
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaR PGI
name: glucose-6-phosphate isomerase
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
reversible: true
fast: false
product: MODEL1310110022#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/5.3.1.9
modifier: MODEL1310110022#

metaM udp e
name: UDP(3-)
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB00295
is: SBO:0000247
type: Species
is: CHEBI:58223
constant: false
boundary condition: false

metaM tcynt m
name: thiocyanate
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:18022
has only substance units: false
is: HMDB01453
type: Species
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_9242dc64_848d_4e69_b2ae_af15e0f560ad
name: LDHB
boundary condition: true
is encoded by: hsa:3945
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
is: P07195

metaM HC02217 e
has only substance units: false
constant: false
is: CHEBI:27647
initial amount: NaN
initial concentration: 1.0
name: prostaglandin-g2
is: SBO:0000247
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_42edd4ce_8a8c_46dd_b516_6346980a5aeb
boundary condition: true
initial concentration: NaN
is: Q1EHB4
initial amount: NaN
is encoded by: hsa:159963
name: SLC5A12
is: SBO:0000252
has only substance units: false
constant: false
type: Species

metaR CYTK5
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
modifier: MODEL1310110022#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
product: MODEL1310110022#
is: SBO:0000176
reactant: MODEL1310110022#
name: cytidylate kinase (dCMP)
fast: false
kinetic law: MODEL1310110022#

metaR MI1345PP
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
type: Reaction
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
product: MODEL1310110022#
is described by: ECO:0000269
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.1.3.86
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.56
reversible: false
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.1.3.36

http://identifiers.org/biomodels.db/MODEL1310110022#_9ea91363_7194_464c_99db_fa491c6bfd56
is: D3DWC4
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:259230
type: Species
is: SBO:0000252
name: SGMS1
initial concentration: NaN
initial amount: NaN

metaM HC00361 c
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
name: sedoheptulose 1,7-bisphosphate(4-)
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58335

http://identifiers.org/biomodels.db/MODEL1310110022#_99f67452_39ba_4f00_83e7_5679581f4390
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4832
constant: false
is: Q13232
has only substance units: false
initial amount: NaN
name: NME3

metaR r0941
fast: false
kinetic law: MODEL1310110022#
is: SBO:0000185
reversible: true
name: Free diffusion
reactant: MODEL1310110022#
product: MODEL1310110022#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:

metaR r2093
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110022#
is: SBO:0000185
reactant: MODEL1310110022#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reversible: true
product: MODEL1310110022#
modifier: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_0345ebce_cfd3_49d7_9dd6_b4962f4ff7c6
has only substance units: false
is encoded by: hsa:2720
is: SBO:0000252
is: P16278
type: Species
initial amount: NaN
constant: false
name: GLB1
initial concentration: NaN
boundary condition: true

metaM coa n
has only substance units: false
is: SBO:0000247
is: HMDB01423
initial amount: NaN
boundary condition: false
is: CHEBI:57287
type: Species
constant: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
name: coenzyme A(4-)
initial concentration: 1.0

metaR CYTK1
type: Reaction
reactant: MODEL1310110022#
is described by: ECO:0000269
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
modifier: MODEL1310110022#
name: cytidylate kinase (CMP)
kinetic law: MODEL1310110022#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110022#_2ad235f0_820e_48e3_ba48_4fed9e876254
has part: P07195
is encoded by: hsa:3939
initial amount: NaN
constant: false
type: Species
has only substance units: false
is encoded by: hsa:3945
has part: P00338
name: LDHA:LDHB
initial concentration: NaN
boundary condition: true
is: SBO:0000297

metaM thf c
is: CHEBI:57453
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB01846
is: C00101
name: 5,6,7,8-Tetrahydrofolate
initial amount: NaN
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
type: Species
boundary condition: false
initial concentration: 1.0

metaR DNDPt14m
modifier: MODEL1310110022#
product: MODEL1310110022#
kinetic law: MODEL1310110022#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110022#
type: Reaction
name: dUDP transport via dTDP antiport
reversible: false
is described by: ECO:0000269

metaR LNSTLSr
is described by: ECO:0000134
fast: false
product: MODEL1310110022#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4047.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.4.99.7 Confidence Level: 2 AUTHORS: PMID:17925399,PMID:17925400,PMID:18830876,PMID:18830877 NOTES:NCD ER version - NJ
is version of: http://identifiers.org/ec-code/5.4.99.7
reversible: false
name: lanosterol synthase
kinetic law: MODEL1310110022#
type: Reaction
reactant: MODEL1310110022#
modifier: MODEL1310110022#

metaM ksi deg19 l
is: SBO:0000247
constant: false
boundary condition: false
name: keratan sulfate I, degradation product 19
initial concentration: 1.0
is: CHEBI:57455
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C146H236N10O124S6 CHARGE: -6
is: HMDB01354

metaR NTD7
type: Reaction
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: (22978.1) or (93034.2) or (93034.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
product: MODEL1310110022#
is: SBO:0000176
name: 5'-nucleotidase (AMP)
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.1.3.5
is described by: ECO:0000269
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110022#_89de82f5_b835_4a9c_a9d5_a865b92fdc26
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
is: Q9P0Z9
is encoded by: hsa:51268
initial concentration: NaN
boundary condition: true
name: PIPOX

http://identifiers.org/biomodels.db/MODEL1310110022#_ae28378d_6733_481c_9e32_39f6ca0d7370
is encoded by: hsa:292
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
name: SLC25A5
initial amount: NaN
constant: false
is: SBO:0000252
is: Q6NVC0

metaM rib D c
is: HMDB00283
name: D-ribose
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:16988
type: Species
is: SBO:0000247
has only substance units: false

metaR r0942
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110022#
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
product: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:

metaR P450SCC1m
name: cholesterol monooxygenase
is: SBO:0000176
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
fast: false
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
product: MODEL1310110022#
reversible: true

metaR CYTK2
product: MODEL1310110022#
name: cytidylate kinase (dCMP)
is described by: ECO:0000269
reactant: MODEL1310110022#
type: Reaction
fast: false
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110022#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176

metaR 10FTHFtm
reactant: MODEL1310110022#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110022#
fast: false
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
product: MODEL1310110022#
is: SBO:0000185
reversible: true

metaR BTNDm
is described by: ECO:0000269
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.5.1.12
type: Reaction
product: MODEL1310110022#
name: biotinidase (biotin), mitochondrial
modifier: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:Also acts on biotin esters IT
reversible: false
is: SBO:0000176
fast: false

metaM coa m
initial amount: NaN
boundary condition: false
name: Coenzyme A
is: HMDB01423
type: Species
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
constant: false
has only substance units: false
is: CHEBI:57287
is: SBO:0000247
is: C00010
initial concentration: 1.0

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

metaR r2094
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110022#
is: SBO:0000185
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110022#
type: Reaction

metaM idp e
constant: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: IDP(3-)
initial amount: NaN
is: HMDB03335
is: CHEBI:58280

metaR MI1PP
is described by: ECO:0000269
product: MODEL1310110022#
name: myo-inositol 1-phosphatase
kinetic law: MODEL1310110022#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.25
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
reactant: MODEL1310110022#
modifier: MODEL1310110022#
is: SBO:0000176
type: Reaction

metaR GALASE14ly
kinetic law: MODEL1310110022#
type: Reaction
name: beta-galactosidase, lysosomal
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
product: MODEL1310110022#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false

metaM alpam m
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H21N2OS2 CHARGE: 1 INCHI: InChI=1/C9H20N2OS2/c10-7-14-6-5-8(13)3-1-2-4-9(11)12/h8,13H,1-7,10H2,(H2,11,12)
name: S-aminomethyldihydrolipoamide
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB06239
boundary condition: false
type: Species

metaM udp g
initial amount: NaN
name: UDP(3-)
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
boundary condition: false
type: Species
is: HMDB00295
is: CHEBI:58223
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110022#_f9de42e0_3613_4063_8bac_ca772979a7f1
initial concentration: NaN
type: Species
has only substance units: false
is: Q01959
boundary condition: true
is encoded by: hsa:6531
constant: false
is: SBO:0000252
name: SLC6A3
initial amount: NaN

metaR EX ksi LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_18620b23_1d72_4490_a717_b2358dbe4fb9
type: Species
is: SBO:0000252
boundary condition: true
is: P48448
initial amount: NaN
has only substance units: false
constant: false
name: ALDH3B2
initial concentration: NaN
is encoded by: hsa:222

metaM sbt D c
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
initial amount: NaN
name: D-glucitol
type: Species
constant: false
is: HMDB00247
initial concentration: 1.0
is: CHEBI:17924
has only substance units: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110022#_5c48554e_3f41_4742_940b_ae9445b8f6dd
is: Q8NCL4
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:11226
constant: false
boundary condition: true
name: GALNT6
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_dad5e24a_7118_483c_b381_d5af99e2269d
type: Species
is: SBO:0000252
is encoded by: hsa:645
is: P30043
constant: false
boundary condition: true
initial amount: NaN
name: BLVRB
has only substance units: false
initial concentration: NaN

metaM pi c
is: SBO:0000247
has only substance units: false
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: HO4P CHARGE: -2
is: CHEBI:43474
is: HMDB00973
is: C00009
name: hydrogenphosphate

metaR EX for LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Formate exchange
type: Reaction

metaR 10FTHFtl
reversible: true
kinetic law: MODEL1310110022#
fast: false
product: MODEL1310110022#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD, IT
name: 10-Formyltetrahydrofolate lysosomal transport via diffusion
reactant: MODEL1310110022#

metaR CYTK3
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
type: Reaction
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.7.4.3
product: MODEL1310110022#
reversible: true
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110022#
name: cytidylate kinase (CMP)(GTP)
fast: false

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

metaM dsmsterol r
name: desmosterol
constant: false
type: Species
boundary condition: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00847 EHMN_ABBREVIATION: C01802
is: HMDB02719
initial amount: NaN
is: CHEBI:17737
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110022#_eb7648a4_f977_4088_85de_85b281bdaf0d
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: P22830
name: FECH
has only substance units: false
type: Species
constant: false
is encoded by: hsa:2235
is: SBO:0000252

metaR RE3346C
fast: false
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
notes: GENE_ASSOCIATION: (223.1) or (218.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110022#
is: SBO:0000176
name: RE3346

metaM thf e
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:57453
is: HMDB01846
name: (6S)-5,6,7,8-tetrahydrofolate(2-)
has only substance units: false
initial amount: NaN
notes: FORMULA: C19H21N7O6 CHARGE: -2 INCHI: InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
type: Species

metaR r2095
modifier: MODEL1310110022#
is: SBO:0000185
reactant: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110022#
fast: false
reversible: true
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110022#

metaM pe hs m
constant: false
name: phosphatidylethanolamine
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
has only substance units: false
is: CHEBI:16038
initial amount: NaN

metaM cholcoa c
initial amount: NaN
is: HMDB01374
constant: false
name: choloyl-CoA(4-)
is: SBO:0000247
is: CHEBI:57373
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110022#_6f7a6785_db26_435c_86d2_ce14f95c419d
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:55902
is: Q5QPH3
name: ACSS2
initial amount: NaN
boundary condition: true

metaR NDPK9n
reactant: MODEL1310110022#
modifier: MODEL1310110022#
product: MODEL1310110022#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
reversible: true
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
is described by: ECO:0000269
type: Reaction

metaR r2014
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
reactant: MODEL1310110022#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
modifier: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_a6219caf_114f_43ed_939c_84b8d1a25f3d
is encoded by: hsa:5091
is: SBO:0000252
initial amount: NaN
type: Species
name: PC
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR GLCURtly
is described by: ECO:0000269
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
fast: false
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD
reversible: true
name: glucuronate transport into lysososme
is: SBO:0000185
product: MODEL1310110022#
type: Reaction

metaR r0944
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
name: Active transport
fast: false
reversible: true
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
is: SBO:0000185
product: MODEL1310110022#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_76624a36_43b1_402c_be51_890dd9e1e1e4
type: Species
boundary condition: true
constant: false
is encoded by: hsa:4830
is: SBO:0000297
name: NME1:NME2
initial concentration: NaN
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_f0896288_658a_4ec8_9407_c31257c888a9
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
name: SLC16A1
is: B4DKS0
initial concentration: NaN
is encoded by: hsa:6566
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_21eb3050_285c_4924_b389_f95208e9b2b5
is encoded by: hsa:8050
is: O00330
constant: false
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
name: PDHX
initial amount: NaN

metaR NACHEX19ly
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
reversible: false
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110022#
reactant: MODEL1310110022#

metaM rib D e
type: Species
name: D-ribose
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
is: HMDB00283
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16988
has only substance units: false
constant: false

metaR NAIt
reactant: MODEL1310110022#
is: SBO:0000185
name: Na+ / iodide cotransport
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
type: Reaction
fast: false
product: MODEL1310110022#
modifier: MODEL1310110022#
reversible: true
kinetic law: MODEL1310110022#

metaR DOCOSACTDe
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: uptake of docosanoic acid by cells by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_93c5f9a3_6e97_4d54_9e33_625c5b295990
is: SBO:0000252
is: Q9Y6M9
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
name: NDUFB9
is encoded by: hsa:4715
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_479a71c2_78e0_4785_b599_e25c0b4414ba
type: Species
is: SBO:0000252
is: O43181
name: NDUFS4
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:4724
has only substance units: false
constant: false

metaM ac m
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
is: CHEBI:30089
is: HMDB00042
is: SBO:0000247
has only substance units: false
name: acetate
initial amount: NaN

metaR GCC2bim
is version of: http://identifiers.org/ec-code/2.1.2.10
reversible: false
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
product: MODEL1310110022#
type: Reaction
modifier: MODEL1310110022#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.8.1.4
fast: false
reactant: MODEL1310110022#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.4.2
name: glycine-cleavage system (lipoamide) irreversible, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110022#_468ea2c0_8c4f_4c05_93e3_f86a48ff5011
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:1103
name: CHAT
initial concentration: NaN
type: Species
is: P28329

metaM 1pyr5c m
is: HMDB01301
boundary condition: false
is: C03912
constant: false
is: CHEBI:15893
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
has only substance units: false
is: SBO:0000247
name: 1-Pyrroline-5-carboxylate

metaR NACHEX26ly
kinetic law: MODEL1310110022#
reversible: false
reactant: MODEL1310110022#
product: MODEL1310110022#
modifier: MODEL1310110022#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110022#_d8d7ca20_5806_443b_8cda_465f65800c1d
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:126129
type: Species
constant: false
name: CPT1C
initial amount: NaN
is: Q8TCG5
has only substance units: false

metaR ACACT10m
fast: false
type: Reaction
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.3.1.9
reactant: MODEL1310110022#
reversible: true
name: acetyl-CoA C-acetyltransferase, mitochondrial
modifier: MODEL1310110022#
product: MODEL1310110022#
is: SBO:0000176
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
is described by: ECO:0000134

metaM CE5788 e
name: kinetensin 1-7
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
type: Species
is: HMDB02710
boundary condition: false
is: CHEBI:27485
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110022#_5c8d9410_adf9_46aa_b687_3f59abc13b5f
initial concentration: NaN
is encoded by: hsa:8140
is: Q8IV97
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
constant: false
name: SLC7A5

metaR r2096
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110022#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110022#
reactant: MODEL1310110022#
type: Reaction
reversible: true
product: MODEL1310110022#
fast: false
is: SBO:0000185
is described by: ECO:0000000

metaM gthox m
is: CHEBI:58297
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
initial amount: NaN
constant: false
has only substance units: false
is: HMDB03337
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110022#_74a4f85a_8756_4f60_b91b_0f74d2f9a440
is encoded by: hsa:8871
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
name: SYNJ2
initial concentration: NaN
is: SBO:0000252
is: O15056

metaM oxa m
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
name: oxalate(2-)
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
is: CHEBI:30623
type: Species
is: HMDB02329

metaR FORtr
name: FOR transporter, endoplasmic reticulum
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110022#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reactant: MODEL1310110022#
product: MODEL1310110022#
reversible: true

metaR r0434
is: SBO:0000176
fast: false
is described by: ECO:0000000
product: MODEL1310110022#
reversible: true
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
type: Reaction
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
reactant: MODEL1310110022#

metaM pi e
name: hydrogenphosphate
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
constant: false
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB00973
is: C00009
is: CHEBI:43474
is: SBO:0000247

metaM ksii core2 deg6 l
is: SBO:0000247
name: keratan sulfate II (core 2-linked), degradation product 6
boundary condition: false
type: Species
is: CHEBI:12936
has only substance units: false
initial concentration: 1.0
is: HMDB00143
notes: FORMULA: C44H72N4O33SX CHARGE: -1
initial amount: NaN
constant: false

metaR KCC2t
type: Reaction
kinetic law: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
modifier: MODEL1310110022#
name: K+-Cl- cotransporter (NH4+)
is: SBO:0000185
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110022#
product: MODEL1310110022#

metaR EX 10fthf LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-Formyltetrahydrofolate exchange
type: Reaction

metaM idp c
boundary condition: false
is: SBO:0000247
name: IDP(3-)
initial concentration: 1.0
is: CHEBI:58280
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
has only substance units: false
type: Species
initial amount: NaN
is: HMDB03335
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_b97938f5_fceb_4fb3_a0c6_3338181d4da2
boundary condition: true
is: SBO:0000252
is: P16885
name: PLCG2
is encoded by: hsa:5336
type: Species
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_7cfaf39c_080d_4e16_857e_a7eff8c9599e
boundary condition: true
constant: false
initial concentration: NaN
name: MTHFS
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:10588
is: P49914

metaM cgly e
is: HMDB00078
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
constant: false
boundary condition: false
name: L-cysteinylglycine
is: CHEBI:4047

metaR r0899
type: Reaction
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
name: Amino acid transporter ATB0+ Facilitated diffusion
product: MODEL1310110022#
reversible: true
fast: false
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110022#

metaR r0208
product: MODEL1310110022#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/4.4.1.1
fast: false
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
reactant: MODEL1310110022#
reversible: true
kinetic law: MODEL1310110022#

metaR r0937
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Transport reaction
product: MODEL1310110022#
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000185

metaM ksi deg12 l
has only substance units: false
boundary condition: false
notes: FORMULA: C174H279N12O153S9 CHARGE: -9
is: CHEBI:12936
is: HMDB00143
name: keratan sulfate I, degradation product 12
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0

metaM val L c
boundary condition: false
constant: false
has only substance units: false
name: L-valine
initial concentration: 1.0
type: Species
is: CHEBI:16414
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
initial amount: NaN
is: HMDB00883
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110022#_32b42011_069b_4030_ad31_19f1764143fd
initial amount: NaN
name: FASN
is encoded by: hsa:2194
type: Species
constant: false
is: P49327
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM ksii core2 deg9 l
notes: FORMULA: C30H50N3O20X CHARGE: 0
is: CHEBI:12936
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB00143
is: SBO:0000247
has only substance units: false
type: Species
name: keratan sulfate II (core 2-linked), degradation product 9

http://identifiers.org/biomodels.db/MODEL1310110022#_cab77c13_9033_45f3_8e1e_ea3cf00e9e5b
type: Species
is: P00338
constant: false
has only substance units: false
name: LDHA
initial amount: NaN
is encoded by: hsa:3939
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaM pnto R c
constant: false
is: SBO:0000247
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
initial amount: NaN
is: HMDB00210
name: (R)-Pantothenate
is: CHEBI:7916
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0

metaR APOCFm
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:IT faked reaction to balance reaction in human biotin metabolism
reactant: MODEL1310110022#
type: Reaction
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reversible: false
fast: false
name: Apocarboxylase formation, mitochondrial

metaR RE0926E
modifier: MODEL1310110022#
reversible: true
kinetic law: MODEL1310110022#
fast: false
product: MODEL1310110022#
is: SBO:0000176
is described by: ECO:0000000
name: RE0926
is version of: http://identifiers.org/ec-code/3.2.1.17
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.1
reactant: MODEL1310110022#

metaM cmp e
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: CMP(2-)
is: HMDB00095
initial concentration: 1.0
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: CHEBI:60377
has only substance units: false
constant: false
type: Species

metaM co2 e
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB01967
is: C00011
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
initial concentration: 1.0
name: CO2
has only substance units: false
constant: false
is: CHEBI:16526
type: Species

metaR DUDPtn
name: dUDP nuclear transport
is: SBO:0000185
reversible: true
type: Reaction
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110022#
is described by: ECO:0000000
product: MODEL1310110022#
fast: false

metaM 5mthf c
notes: FORMULA: C20H24N7O6 CHARGE: -1
is: C00440
initial amount: NaN
is: HMDB01396
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:3729
name: 5-Methyltetrahydrofolate
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110022#_804a236e_aa93_443b_beb1_49ec161a9edf
name: ACP1
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:52
constant: false
is: Q59EH3
type: Species
is: SBO:0000252
initial concentration: NaN

metaR PROSTGF2t
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
type: Reaction
is: SBO:0000185
reactant: MODEL1310110022#
product: MODEL1310110022#
is described by: ECO:0000269
modifier: MODEL1310110022#
reversible: true
name: prostaglandin uniport
fast: false
kinetic law: MODEL1310110022#

metaR r0936
name: Transport reaction
is: SBO:0000185
fast: false
product: MODEL1310110022#
reversible: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#

metaM HC02179 e
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
is: CHEBI:34306
initial amount: NaN
name: 20-hydroxy-arachidonate
type: Species
is: SBO:0000247

metaR NDPK5n
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110022#
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear
is: SBO:0000176
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
reversible: true
fast: false
product: MODEL1310110022#
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
type: Reaction
is described by: ECO:0000304

metaM glcur l
initial amount: NaN
name: D-glucuronate
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:15748
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: HMDB00127
boundary condition: false

metaM dgmp e
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB01044
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
is: SBO:0000247
name: dGMP(2-)
type: Species
has only substance units: false
is: CHEBI:57673

http://identifiers.org/biomodels.db/MODEL1310110022#_96995adb_094b_47ed_a707_f4dfe4e2596f
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:2356
is: Q05932
name: FPGS
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
constant: false

metaM utp e
constant: false
initial amount: NaN
boundary condition: false
name: UTP(4-)
initial concentration: 1.0
is: HMDB00285
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:46398
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075

http://identifiers.org/biomodels.db/MODEL1310110022#_68e41302_3d99_4692_b3bc_ed74928ee7a3
has only substance units: false
name: ALAD
initial amount: NaN
type: Species
is: Q6ZMU0
initial concentration: NaN
is encoded by: hsa:210
constant: false
is: SBO:0000252
boundary condition: true

metaR PE HSter
product: MODEL1310110022#
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110022#
name: phosphatidylethanolamine scramblase
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:
is: SBO:0000185
reversible: true

metaM pi r
boundary condition: false
initial amount: NaN
is: HMDB00973
name: hydrogenphosphate
type: Species
is: C00009
constant: false
has only substance units: false
is: CHEBI:43474
initial concentration: 1.0
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110022#_cfe40e85_c255_448c_a244_75fc8e112dac
is encoded by: hsa:BE966236
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
name: _BE966236_1_c
initial amount: NaN

metaM Ser Thr l
name: protein-linked serine or threonine residue (O-glycosylation site)
initial concentration: 1.0
is: SBO:0000247
is: HMDB01342
constant: false
is: CHEBI:37568
notes: FORMULA: XH CHARGE: 0
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
is: C00459

http://identifiers.org/biomodels.db/MODEL1310110022#_c06d9a75_6533_430f_8ba5_598bdcf8937d
has only substance units: false
name: FOLR1
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:2348

metaR DNDPt29m
name: dCDP transport via dADP antiport
reversible: false
reactant: MODEL1310110022#
is: SBO:0000185
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
fast: false
type: Reaction

metaR CERT2gt
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110022#
fast: false
modifier: MODEL1310110022#
reactant: MODEL1310110022#
reversible: true
is: SBO:0000185
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
is version of: http://identifiers.org/ec-code/2.7.11.1
name: ceramide transport protein

metaR LDH D
fast: false
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.1.2.4
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)
type: Reaction
kinetic law: MODEL1310110022#
is: SBO:0000176
name: D-lactate dehydrogenase
reversible: true
product: MODEL1310110022#
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110022#_c8ea780b_5aeb_4141_ba5f_c0adbffd59ed
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:2746
is: SBO:0000252
is: E9KL48
name: GLUD1
type: Species
initial amount: NaN

metaR UAG4E
modifier: MODEL1310110022#
reactant: MODEL1310110022#
fast: false
is version of: http://identifiers.org/ec-code/5.1.3.2
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110022#
name: UDP-N-acetylglucosamine 4-epimerase
product: MODEL1310110022#
is: SBO:0000176
type: Reaction
reversible: true
is described by: ECO:0000304

metaR PItx
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
product: MODEL1310110022#
fast: false
name: Phosphate transporter, peroxisome
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110022#
reversible: true
reactant: MODEL1310110022#

metaM val L e
constant: false
boundary condition: false
name: L-valine
type: Species
has only substance units: false
is: CHEBI:16414
initial concentration: 1.0
initial amount: NaN
is: HMDB00883
is: SBO:0000247
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174

http://identifiers.org/biomodels.db/MODEL1310110022#_bd309fe0_7345_4749_a0ae_e649e4ae93bf
name: NT5E
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
is: P21589
constant: false
has only substance units: false
is encoded by: hsa:4907

metaM atp m
is: C00002
is: CHEBI:57299
has only substance units: false
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
is: HMDB00538
boundary condition: false
initial concentration: 1.0
name: ATP(4-)

metaM pnto R e
is: SBO:0000247
initial amount: NaN
is: HMDB00210
is: CHEBI:7916
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
name: (R)-Pantothenate
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
constant: false

metaM HC00319 c
boundary condition: false
is: CHEBI:30794
name: Malonate
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_1ba2db64_c875_4461_b55f_2256bbb1475d
initial concentration: NaN
is: SBO:0000252
is: O15305
is encoded by: hsa:5373
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
name: PMM2
type: Species

metaR BHBt
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction
kinetic law: MODEL1310110022#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110022#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
product: MODEL1310110022#
fast: false

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_d4b5fb6b_131f_41f3_934d_f87b35560917
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:65985
boundary condition: true
is: SBO:0000252
is: Q86V21
initial amount: NaN
name: AACS
type: Species

metaR r2023
reversible: false
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
type: Reaction
product: MODEL1310110022#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110022#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM chlstol r
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: 5alpha-cholesta-7,24-dien-3beta-ol
initial concentration: 1.0
is: HMDB06842
constant: false
is: CHEBI:16290
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_485ed542_dcd8_4bf0_aef7_ebd2217cb9a6
name: ADH6
boundary condition: true
has only substance units: false
is encoded by: hsa:130
initial amount: NaN
initial concentration: NaN
is: P28332
is: SBO:0000252
type: Species
constant: false

metaM cmp g
name: CMP(2-)
constant: false
is: CHEBI:60377
type: Species
is: SBO:0000247
is: HMDB00095
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
boundary condition: false
initial amount: NaN

metaR r0934
product: MODEL1310110022#
reactant: MODEL1310110022#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: false
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
kinetic law: MODEL1310110022#
fast: false

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

metaR r1512
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110022#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110022#
fast: false
is: SBO:0000185
product: MODEL1310110022#
name: Utilized transport
type: Reaction

metaM gthox c
type: Species
constant: false
is: CHEBI:58297
name: Oxidized glutathione
boundary condition: false
is: C00127
initial concentration: 1.0
is: HMDB03337
is: SBO:0000247
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
has only substance units: false
initial amount: NaN

metaM 34hpp e
is: HMDB00707
initial concentration: 1.0
is: CHEBI:36242
boundary condition: false
constant: false
name: 3-(4-hydroxyphenyl)pyruvate
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
initial amount: NaN

metaM HC02179 c
boundary condition: false
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
is: CHEBI:34306
constant: false
name: 20-hydroxy-arachidonate
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaR UAGDP
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.23
fast: false
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
is described by: ECO:0000269
reactant: MODEL1310110022#
product: MODEL1310110022#
type: Reaction
name: UDP-N-acetylglucosamine diphosphorylase
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110022#_3aa014e2_9634_42ba_a7ae_4f021910d421
is encoded by: hsa:226
is: SBO:0000252
has only substance units: false
is: P04075
boundary condition: true
type: Species
name: ALDOA
initial amount: NaN
constant: false
initial concentration: NaN

metaM bilirub r
initial concentration: 1.0
name: bilirubin(2-)
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:57977
type: Species
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
is: HMDB00054
is: SBO:0000247

metaM utp c
is: HMDB00285
is: SBO:0000247
type: Species
name: UTP
initial concentration: 1.0
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
initial amount: NaN
boundary condition: false
constant: false
is: C00075
is: CHEBI:46398
has only substance units: false

metaM atp n
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
name: ATP(3-)
is: SBO:0000247
constant: false
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
is: HMDB00538
initial concentration: 1.0
is: CHEBI:57299

metaR RE0453C
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
product: MODEL1310110022#
kinetic law: MODEL1310110022#
reversible: true
type: Reaction
name: RE0453
reactant: MODEL1310110022#
is: SBO:0000176
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110022#_e28c9a8a_ace5_488a_b591_40b804f5ee75
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
is: Q86XP1
is encoded by: hsa:160851
name: DGKH
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110022#_0cc61b6c_f5f2_4b4a_989d_38aa2821af96
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
name: AADAT
is: Q4W5N8
is encoded by: hsa:51166

http://identifiers.org/biomodels.db/MODEL1310110022#_0b0264e6_62a8_4a30_884d_3903a2d68b93
name: DEGS1
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:8560
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110022#_15045ea3_36c0_41c7_8095_d31ac7da58ec
has only substance units: false
is encoded by: hsa:10935
name: PRDX3
boundary condition: true
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
is: E9PH29
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_9ec56c19_5745_4e36_aa55_feb20969455b
boundary condition: true
name: ACSS1
is: SBO:0000252
initial amount: NaN
type: Species
is: Q9NUB1
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:84532

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

metaM pi m
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
is: C00009
initial concentration: 1.0
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: CHEBI:43474
type: Species
is: HMDB00973
name: hydrogenphosphate

metaM tyr L e
name: L-tyrosine
initial amount: NaN
has only substance units: false
type: Species
constant: false
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
is: SBO:0000247
is: CHEBI:17895
initial concentration: 1.0
is: HMDB00158
boundary condition: false

metaM gtp n
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
type: Species
is: HMDB01273
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
name: GTP(4-)
boundary condition: false
is: CHEBI:37565

http://identifiers.org/biomodels.db/MODEL1310110022#_d1c4b475_29a4_44c5_90b6_b3e4ec1a1107
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: FOLR1
constant: false
is encoded by: hsa:2348
is: SBO:0000252

metaR SPMDOX
type: Reaction
reversible: false
product: MODEL1310110022#
fast: false
name: Spermidine:(acceptor) oxidoreductase
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: beta-Alanine metabolism EC Number: 1.5.99.6 Confidence Level: 2 AUTHORS: PMID:10657958 NOTES:SAB
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110022#_12a2eb5f_54ca_48e4_acf0_a4d2fe4a0396
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6647
has only substance units: false
is: P00441
type: Species
constant: false
boundary condition: true
name: SOD1

http://identifiers.org/biomodels.db/MODEL1310110022#_0d167ef3_49dc_4bf4_8130_878c9af0c4ed
boundary condition: true
constant: false
is: SBO:0000252
is: Q9H999
initial amount: NaN
is encoded by: hsa:79646
initial concentration: NaN
name: PANK3
has only substance units: false
type: Species

metaM Lcystin c
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
initial concentration: 1.0
boundary condition: false
is: CHEBI:16283
is: HMDB00192
is: SBO:0000247
initial amount: NaN
name: L-cystine
constant: false
has only substance units: false
type: Species

metaR DM taur LPAREN c RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: demand reaction for taurine
type: Reaction

metaM prostgd2 r
is: CHEBI:57406
is: HMDB01403
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
boundary condition: false
name: prostaglandin D2(1-)
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_e49c12a3_1ee8_451f_ab65_205509b71de6
has only substance units: false
type: Species
boundary condition: true
constant: false
name: VNN3
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:55350
is: SBO:0000252

metaM ksi deg28 l
notes: FORMULA: C104H170N7O85S3 CHARGE: -3
name: keratan sulfate I, degradation product 28
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:57455
is: HMDB01354
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN

metaR RNMK
name: ribosylnicotinamide kinase
type: Reaction
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (54981.1) SUBSYSTEM: NAD metabolism EC Number: 2.7.1.22 Confidence Level: 4 AUTHORS: PMID:15137942 NOTES:
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.7.1.22
reversible: false
is: SBO:0000176
product: MODEL1310110022#
modifier: MODEL1310110022#

metaR SPHS1Pte
name: sphingosine-1-phosphate transport
product: MODEL1310110022#
reversible: true
type: Reaction
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ
reactant: MODEL1310110022#
is: SBO:0000185
is described by: ECO:0000000
fast: false

metaM 6thf e
is: http://identifiers.org/pubchem.compound/169691
name: hexaglutamyl folate (THF)
initial amount: NaN
constant: false
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1

metaM Ser Thr g
is: HMDB00143
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:0
name: protein-linked serine or threonine residue (O-glycosylation site)
constant: false
notes: FORMULA: XH CHARGE: 0
is: C00124
type: Species
initial amount: NaN

metaM 34hpp c
initial amount: NaN
boundary condition: false
is: CHEBI:36242
has only substance units: false
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
name: 3-(4-hydroxyphenyl)pyruvate
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB00707

metaR RE2626C
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110022#
is described by: ECO:0000000
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
name: RE2626
reversible: true

metaR S6TASE23ly
name: N-acetylglucosamine-6-sulfatase, lysosomal
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
type: Reaction
modifier: MODEL1310110022#
is: SBO:0000176
product: MODEL1310110022#
fast: false
kinetic law: MODEL1310110022#
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.14

metaM gtp m
initial concentration: 1.0
constant: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: CHEBI:37565
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
name: GTP
is: C00044
is: HMDB01273
is: SBO:0000247

metaR NDPK10n
kinetic law: MODEL1310110022#
reversible: true
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:dIDP), nuclear
modifier: MODEL1310110022#
is described by: ECO:0000304
reactant: MODEL1310110022#
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions. . Presence in the nucleus

metaR DHCR72r
is version of: http://identifiers.org/ec-code/1.3.1.21
name: 7-dehydrocholesterol reductase
is described by: ECO:0000269
reversible: false
fast: false
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
is: SBO:0000176
reactant: MODEL1310110022#
type: Reaction
modifier: MODEL1310110022#
product: MODEL1310110022#
kinetic law: MODEL1310110022#

metaM 2obut m
is: CHEBI:16763
type: Species
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-2-3(5)4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: 2-oxobutanoate
has only substance units: false
is: HMDB00005

metaM imp c
name: IMP
has only substance units: false
initial concentration: 1.0
is: C00130
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB00175
is: CHEBI:58053
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
constant: false

metaM ipdp x
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
is: CHEBI:128769
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
boundary condition: false
name: isopentenyl diphosphate(3-)
is: HMDB01347

metaR EX tdchola LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: taurochenodeoxycholate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_1f51f896_e2d1_4729_a8b0_ee583b0ab04e
initial concentration: NaN
is: B4DR31
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:1808
name: DPYSL2

metaM pi n
is: CHEBI:43474
boundary condition: false
type: Species
name: hydrogenphosphate
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB00973

metaR EX din LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyinosine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_a6c9fc35_06cf_4c07_902a_8a47d0aa71ba
constant: false
initial amount: NaN
is encoded by: hsa:4830
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000297
name: NME1:NME2
has only substance units: false

metaR CHOLPtg
product: MODEL1310110022#
reversible: true
kinetic law: MODEL1310110022#
fast: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - no strong evidence to indicate further lysosomal or golgi metabolism NJ
name: choline phosphate intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110022#_2e871b96_4f01_42f9_b6c7_376bd7d65b17
is: Q16836
is encoded by: hsa:3033
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: HADH
has only substance units: false
constant: false
type: Species

metaM nad m
is: SBO:0000247
is: CHEBI:57540
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3305
initial amount: NaN
type: Species
is: C00003
is: HMDB00902
constant: false
has only substance units: false
name: Nicotinamide adenine dinucleotide

metaM HC01603 c
boundary condition: false
type: Species
constant: false
name: 10-formyltetrahydrofolate-[Glu](5)
initial amount: NaN
is: HMDB02704
is: CHEBI:21338
initial concentration: 1.0
notes: FORMULA: C40H45N11O19 CHARGE: -6
has only substance units: false
is: SBO:0000247

metaR ACCOAC
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_9450c2d7_e172_4cf4_addd_93ad3ecf5a67
is encoded by: hsa:8525
constant: false
is: SBO:0000252
initial amount: NaN
is: B7Z2M9
boundary condition: true
initial concentration: NaN
type: Species
name: DGKZ
has only substance units: false

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_6972d366_b43d_45ea_a8de_56c971a9b43a
is: SBO:0000252
is encoded by: hsa:3028
initial concentration: NaN
constant: false
has only substance units: false
name: HSD17B10
type: Species
initial amount: NaN
boundary condition: true
is: Q99714

metaM co2 c
notes: FORMULA: CO2 CHARGE: 0
is: SBO:0000247
is: HMDB01967
type: Species
initial concentration: 1.0
initial amount: NaN
is: C00011
name: CO2
is: CHEBI:3313
has only substance units: false
boundary condition: false
constant: false

metaM cmp c
is: SBO:0000247
is: C00055
type: Species
initial concentration: 1.0
initial amount: NaN
name: CMP
is: HMDB00095
has only substance units: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
constant: false
boundary condition: false
is: CHEBI:60377

metaR BILIRUBtr
product: MODEL1310110022#
kinetic law: MODEL1310110022#
fast: false
reversible: true
type: Reaction
name: lipid, flip-flop intracellular transport
is: SBO:0000185
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is described by: ECO:0000000

metaM HC00342 m
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
initial amount: NaN
boundary condition: false
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:16383
name: cis-aconitate(3-)
is: SBO:0000247

metaR BTNDe
product: MODEL1310110022#
is: SBO:0000176
name: biotinidase (biotin), extracellular
type: Reaction
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.5.1.12
kinetic law: MODEL1310110022#
fast: false
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7509806,PMID:8001986 NOTES:Also acts on biotin esters IT

metaM ksi deg40 l
type: Species
notes: FORMULA: C40H68N2O31 CHARGE: 0
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB00143
is: CHEBI:12936
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: keratan sulfate I, degradation product 40

metaR BILIRED
reversible: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110022#
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.3.1.24
notes: GENE_ASSOCIATION: (645.1) or (644.1) SUBSYSTEM: Heme degradation EC Number: 1.3.1.24 Confidence Level: 0 AUTHORS: PMID:12456881,PMID:7656592,PMID:8117274 NOTES:TDV
modifier: MODEL1310110022#
fast: false
is: SBO:0000176
name: Nad(p)h biliverdin reductase
reactant: MODEL1310110022#

metaR MAN6PI
name: mannose-6-phosphate isomerase
reactant: MODEL1310110022#
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/5.3.1.8
type: Reaction
is: SBO:0000176
product: MODEL1310110022#
is described by: ECO:0000304
fast: false
reversible: true
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110022#_1975136f_0406_440d_ae76_57613cb537ad
initial amount: NaN
boundary condition: true
is: Q8WZ48
initial concentration: NaN
is: SBO:0000252
name: CPT1A
is encoded by: hsa:1374
constant: false
type: Species
has only substance units: false

metaM gmp g
boundary condition: false
name: GMP(3-)
initial amount: NaN
type: Species
has only substance units: false
is: HMDB01397
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58115
constant: false

metaM 5mthf e
is: SBO:0000247
type: Species
is: HMDB01396
notes: FORMULA: C20H24N7O6 CHARGE: -1
name: 5-Methyltetrahydrofolate
constant: false
has only substance units: false
is: CHEBI:3729
initial concentration: 1.0
is: C00440
boundary condition: false
initial amount: NaN

metaR S6TASE21ly
name: N-acetylglucosamine-6-sulfatase, lysosomal
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110022#
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.14
is: SBO:0000176
reversible: true
reactant: MODEL1310110022#
modifier: MODEL1310110022#

metaR PI34P5K
reactant: MODEL1310110022#
is described by: ECO:0000000
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.7.1.68
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
modifier: MODEL1310110022#
is: SBO:0000176
reversible: false
product: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_ace13069_3f28_437a_a04a_8388c9ac467c
constant: false
has only substance units: false
is encoded by: hsa:3074
boundary condition: true
initial concentration: NaN
is: P07686
is: SBO:0000252
initial amount: NaN
type: Species
name: HEXB

metaR DOLGPP Ler
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.4.48 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
reactant: MODEL1310110022#
product: MODEL1310110022#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
name: Dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase (liver)
fast: false
reversible: false
kinetic law: MODEL1310110022#

metaR FUMtm
fast: false
modifier: MODEL1310110022#
name: fumarate transport, mitochondrial
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110022#_6b231b82_dba7_4f51_80bf_97cbf25336c4
has only substance units: false
initial concentration: NaN
constant: false
type: Species
boundary condition: true
is encoded by: hsa:1806
is: SBO:0000252
initial amount: NaN
name: DPYD
is: Q12882

metaM HC00342 c
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: cis-aconitate(3-)
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:16383
type: Species

metaM dcholcoa x
name: chenodeoxycholoyl coenzyme a
initial concentration: 1.0
is: HMDB06292
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
type: Species
is: CHEBI:28701

metaR HSD3B7P
is: SBO:0000176
reversible: false
modifier: MODEL1310110022#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
product: MODEL1310110022#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.181
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#

metaM coa c
is: CHEBI:3312
constant: false
name: Coenzyme A
type: Species
has only substance units: false
is: HMDB01423
is: C00010
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4

metaM CE1944 c
is: CHEBI:36781
name: 1-pyrrolinium
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C4H8N CHARGE: 1 INCHI: InChI=1S/C4H7N/c1-2-4-5-3-1/h3H,1-2,4H2/p+1 EHMN_ABBREVIATION: CE1944
constant: false
initial amount: NaN

metaR r1163
fast: false
product: MODEL1310110022#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:15297262 NOTES:
name: Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter TCDB:2.A.28.1.1
kinetic law: MODEL1310110022#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110022#_bc319879_0239_4f12_838c_31b659503b0f
name: SLC22A2
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:6582
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110022#_24ecd255_1619_4dc2_880e_b1b92411e553
initial concentration: NaN
is: O76082
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:6584
name: SLC22A5

metaM HC01501 c
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: hydroxidodioxidosulfidosulfate(1-)
boundary condition: false
notes: FORMULA: HO3S2 CHARGE: -1 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-1 EHMN_ABBREVIATION: C05529
is: SBO:0000247
type: Species
is: CHEBI:33539
constant: false

metaM gdpfuc g
constant: false
is: CHEBI:57984
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
is: SBO:0000247
is: HMDB01095
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
name: GDP-L-fucose(2-)

metaM atp c
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB00538
initial concentration: 1.0
is: C00002
is: CHEBI:30616
constant: false
type: Species
initial amount: NaN
name: ATP(4-)

metaR r0787
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.1
fast: false
kinetic law: MODEL1310110022#
product: MODEL1310110022#
modifier: MODEL1310110022#
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
reversible: false
reactant: MODEL1310110022#
is: SBO:0000176
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:

metaM dad 2 c
type: Species
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:17256
name: 2-deoxyadenosine
initial concentration: 1.0
is: HMDB00101
has only substance units: false
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
initial amount: NaN

metaR FUT33g
reactant: MODEL1310110022#
reversible: false
notes: GENE_ASSOCIATION: (2525.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.65 Confidence Level: 4 AUTHORS: PMID:12424536,PMID:12493760,PMID:1977660 NOTES:NJ
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.4.1.65
name: fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group included) 1
is: SBO:0000176
product: MODEL1310110022#
type: Reaction
fast: false
is described by: ECO:0000269
modifier: MODEL1310110022#

metaM xol7a r
is: CHEBI:1296
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C03594
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: 20-hydroxycholesterol
is: HMDB01496
type: Species
has only substance units: false
initial amount: NaN

metaM gtp c
is: HMDB01273
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
name: GTP
is: CHEBI:37565
type: Species
initial amount: NaN
is: C00044
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044

metaM val L m
has only substance units: false
name: L-valine
is: HMDB00883
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: CHEBI:16414
constant: false
initial amount: NaN
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_2d01313b_387e_449e_8202_e2195b5e3415
is: SBO:0000252
constant: false
is: Q96E98
is encoded by: hsa:6005
type: Species
boundary condition: true
name: RHAG
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaM glyc m
type: Species
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: Glycerol
is: HMDB00131
is: C00116
constant: false
is: CHEBI:17754
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_ad7dbbf7_fb36_437d_a4dd_749fd05e3160
is encoded by: hsa:9791
is: SBO:0000252
is: P48651
name: PTDSS1
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false

metaR ADSL1
reactant: MODEL1310110022#
modifier: MODEL1310110022#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
name: adenylosuccinate lyase
is described by: ECO:0000269
product: MODEL1310110022#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/4.3.2.2
kinetic law: MODEL1310110022#

metaM Lcystin e
initial concentration: 1.0
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:16283
type: Species
name: L-cystine
is: HMDB00192
initial amount: NaN

metaR r0156
modifier: MODEL1310110022#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.40
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
reversible: false
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
type: Reaction
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_ee8006a1_c0bb_4b37_a78f_feea3a6a4d7a
name: _BF195998_1_x
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:BF195998
constant: false
initial amount: NaN
type: Species
initial concentration: NaN

metaM 1pyr5c c
name: 1-Pyrroline-5-carboxylate
type: Species
is: CHEBI:15893
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: C03912
constant: false
is: SBO:0000247
is: HMDB01301
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912

metaR CYSGLYexR
reversible: true
kinetic law: MODEL1310110022#
is described by: ECO:0000000
name: L-cysteine/glycine reversible exchanger
product: MODEL1310110022#
fast: false
modifier: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_a71a2244_cd1d_4b55_a16e_39ff6d522e56
is encoded by: hsa:AA614647
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: _AA614647_1_c
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_0df30e65_4d6a_4a55_88bd_cec20a039aa1
type: Species
has only substance units: false
is encoded by: hsa:4833
boundary condition: true
name: NME4
is: SBO:0000252
constant: false
initial concentration: NaN
is: O00746
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_dd4c0333_1d92_4e56_8469_55ae2bc329fd
name: _R06874_1_r
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:R06874
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_1a4c19a4_0d42_4450_b94b_e199e868f550
has only substance units: false
is: P23743
name: DGKA
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:1606
constant: false
initial concentration: NaN

metaR r0784
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
product: MODEL1310110022#
fast: false
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.3.1.38
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110022#
modifier: MODEL1310110022#
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15

metaM tyr L c
has only substance units: false
type: Species
is: HMDB00158
name: L-tyrosine
boundary condition: false
constant: false
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:17895

metaM akg m
is: SBO:0000247
is: HMDB00208
constant: false
initial concentration: 1.0
is: CHEBI:16810
name: 2-Oxoglutarate
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
has only substance units: false
is: C00026
initial amount: NaN
boundary condition: false
type: Species

metaR 5MTHFt
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
fast: false
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
type: Reaction
product: MODEL1310110022#
kinetic law: MODEL1310110022#
is described by: ECO:0000269
is: SBO:0000185
reversible: true
modifier: MODEL1310110022#

metaM CE5786 e
is: SBO:0000247
name: kinetensin
is: CHEBI:27485
is: HMDB02710
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786

metaM biocyt m
boundary condition: false
is: http://identifiers.org/pubchem.compound/7886
has only substance units: false
initial amount: NaN
is: HMDB03134
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
is: C05552
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
name: Biocytin

metaR SERGLYexR
is described by: ECO:0000304
kinetic law: MODEL1310110022#
reversible: true
fast: false
name: L-Serine/Glycine reversible exchange
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#

metaM pi x
initial amount: NaN
constant: false
is: HMDB00973
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial concentration: 1.0
name: hydrogenphosphate
is: CHEBI:43474
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110022#_339c8de9_c5fc_43cd_80b6_d64e66014fbb
is encoded by: hsa:23428
is: SBO:0000297
boundary condition: true
name: SLC7A8:SLC3A2
has only substance units: false
type: Species
has part: Q9UHI5
constant: false
initial concentration: NaN
initial amount: NaN

metaR r0157
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
fast: false
is described by: ECO:0000000
modifier: MODEL1310110022#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.4.2
reversible: false
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
product: MODEL1310110022#
reactant: MODEL1310110022#

metaR r0829
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/4.1.1.37
reversible: true
modifier: MODEL1310110022#
is: SBO:0000185
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is described by: ECO:0000000
type: Reaction

metaM atp e
is: HMDB00538
name: ATP(4-)
type: Species
constant: false
is: C00002
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:57299
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_847ee3e5_6951_4272_beb8_0ebd1da175ba
is encoded by: hsa:2542
name: SLC37A4
initial amount: NaN
is: A8K0S7
type: Species
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaR r2361
product: MODEL1310110022#
fast: false
type: Reaction
is: SBO:0000185
reversible: true
reactant: MODEL1310110022#
is described by: ECO:0000000
kinetic law: MODEL1310110022#
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR XOL27OHtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
product: MODEL1310110022#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110022#
fast: false
reversible: true
is: SBO:0000185
name: 27 hydroxy cholesterol transport
reactant: MODEL1310110022#

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

metaR HS2ly
modifier: MODEL1310110022#
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.10.1.1
is described by: ECO:0000000
reactant: MODEL1310110022#
name: heparan-N-sulfatase, lysosomal
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110022#
reversible: false

metaR SUCCt2m
reversible: true
type: Reaction
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is described by: ECO:0000269
fast: false
name: succinate transport, mitochondrial
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
modifier: MODEL1310110022#
is: SBO:0000185

metaM 2obut c
name: 2-Oxobutanoate
has only substance units: false
is: SBO:0000247
is: C00109
is: CHEBI:16763
is: HMDB00005
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
boundary condition: false

metaR r1384
name: Guanosine aminohydrolase EC:3.5.4.15
reactant: MODEL1310110022#
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
fast: false
product: MODEL1310110022#
kinetic law: MODEL1310110022#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110022#_e2fcf8dd_3e52_4b49_9b4b_4cca0b6b92fd
boundary condition: true
is: SBO:0000252
constant: false
type: Species
name: NDUFAB1
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4706
is: O14561
has only substance units: false

metaR FADH2tru
reversible: false
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
is described by: ECO:0000000
kinetic law: MODEL1310110022#
is: SBO:0000185
name: FADH2 transporter, endoplasmic reticulum
product: MODEL1310110022#
type: Reaction
fast: false

metaR LEUKTRA4tr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
name: leukotriene intracellular transport
reactant: MODEL1310110022#
is: SBO:0000185
product: MODEL1310110022#
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110022#

metaR UMPK6n
is described by: ECO:0000269
fast: false
reversible: true
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110022#
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
name: UMP kinase (dCTP),nuclear
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR RE0453N
reactant: MODEL1310110022#
reversible: true
product: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110022#
name: RE0453
fast: false
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_39b7db8f_136d_4f2a_8c9e_4990f432e352
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
name: _AV717590_1_m
boundary condition: true
is encoded by: hsa:AV717590
has only substance units: false
initial concentration: NaN

metaM thp2c x
initial amount: NaN
initial concentration: 1.0
is: HMDB12130
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
is: CHEBI:16987
name: 1-piperideine-6-carboxylate
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
constant: false

metaM crtsl r
initial concentration: 1.0
notes: FORMULA: C21H30O5 CHARGE: 0 INCHI: InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1 EHMN_ABBREVIATION: C00735
boundary condition: false
name: cortisol
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB00063
is: CHEBI:17650
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_7e9aace2_1f70_4093_a809_16185a695cfd
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:5831
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: PYCR1
is: A6NFM2

metaR r1668
product: MODEL1310110022#
fast: false
reactant: MODEL1310110022#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110022#
type: Reaction

metaM bilirub c
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
has only substance units: false
is: HMDB00054
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:57977
type: Species
name: bilirubin(2-)
boundary condition: false
initial amount: NaN

metaM L2aadp c
name: L-2-aminoadipate(1-)
is: CHEBI:58672
type: Species
initial concentration: 1.0
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB00510
constant: false

metaR r2360
is: SBO:0000185
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110022#
name: Organic anion transporter 5 Utilized transport
type: Reaction
reversible: true
is described by: ECO:0000000
product: MODEL1310110022#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110022#_fa04fa70_ac60_43c5_b6ac_a74a67c62056
initial concentration: NaN
is encoded by: hsa:26289
name: AK5
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false
is: SBO:0000252

metaM dhap x
is: http://identifiers.org/pubchem.compound/3411
is: HMDB01473
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:57642
initial amount: NaN
name: Dihydroxyacetone phosphate
type: Species
constant: false
is: SBO:0000247
is: C00111

metaM akg e
is: SBO:0000247
initial concentration: 1.0
name: 2-oxoglutarate(2-)
initial amount: NaN
is: HMDB00208
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: CHEBI:16810
type: Species

metaM triodthy e
boundary condition: false
initial concentration: 1.0
is: CHEBI:18258
name: 3,3',5-triiodo-L-thyronine
is: SBO:0000247
is: HMDB00265
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_6215e93e_e164_42d6_b862_3ac1edf817b2
type: Species
boundary condition: true
is: B4DGD7
is encoded by: hsa:3423
initial concentration: NaN
constant: false
initial amount: NaN
name: IDS
has only substance units: false
is: SBO:0000252

metaR PMANM
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/5.4.2.8
reversible: true
type: Reaction
name: phosphomannomutase
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/5.4.2.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:
modifier: MODEL1310110022#
is: SBO:0000176
reactant: MODEL1310110022#
fast: false

metaR CYTK9n
kinetic law: MODEL1310110022#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110022#
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
fast: false
name: cytidylate kinase (CMP,dCTP),nuclear
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_6338c405_9327_46be_9214_134044cbe382
constant: false
type: Species
boundary condition: true
is: P48065
name: SLC6A12
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6539
has only substance units: false
initial amount: NaN

metaM HC00319 m
is: CHEBI:30794
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
has only substance units: false
name: Malonate
is: SBO:0000247
boundary condition: false

metaM pppg9 m
boundary condition: false
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C34H38N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00656 EHMN_ABBREVIATION: C01079
initial amount: NaN
is: HMDB01097
has only substance units: false
is: C01079
name: Protoporphyrinogen IX
initial concentration: 1.0
is: CHEBI:57307

http://identifiers.org/biomodels.db/MODEL1310110022#_2882e57c_75ee_4a24_b4f5_e8fb6a753145
initial amount: NaN
type: Species
is: P30084
is: SBO:0000252
constant: false
is encoded by: hsa:1892
boundary condition: true
has only substance units: false
name: ECHS1
initial concentration: NaN

metaR r1667
reactant: MODEL1310110022#
product: MODEL1310110022#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110022#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110022#
reversible: true
fast: false

metaM nad r
name: NAD(1-)
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
is: CHEBI:57540
has only substance units: false
is: HMDB00902
type: Species

metaR DNDPt35m
product: MODEL1310110022#
name: dGDP transport via dADP antiport
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
reactant: MODEL1310110022#
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110022#
is: SBO:0000185
type: Reaction

metaR ORNt4m
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
kinetic law: MODEL1310110022#
fast: false
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110022#
name: ornithine mitochondrial transport exchange with citruline
product: MODEL1310110022#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110022#

metaR NS26T2g
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.4.99.3
kinetic law: MODEL1310110022#
name: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
product: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: (55808.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.3 Confidence Level: 0 AUTHORS: PMID:10536037 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
reversible: false
fast: false
reactant: MODEL1310110022#

metaM gdpfuc c
boundary condition: false
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
constant: false
is: SBO:0000247
is: CHEBI:57984
is: HMDB01095
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: GDP-L-fucose(2-)

metaM hxan e
constant: false
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: hypoxanthine
is: CHEBI:17368
boundary condition: false
is: HMDB00157
type: Species
initial amount: NaN

metaR MI134P4P
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
reversible: false
is: SBO:0000176
name: inositol-1,3,4-trisphosphate 4-phosphatase
reactant: MODEL1310110022#
type: Reaction
product: MODEL1310110022#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110022#_55b9bfc9_1ede_4913_aa83_bffe0075a5eb
is encoded by: hsa:4056
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
has only substance units: false
initial amount: NaN
name: LTC4S
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110022#_1408c3de_f9a5_494e_832c_a673d42ecadc
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000297
boundary condition: true
type: Species
name: VNN3:VNN2:VNN1
is encoded by: hsa:55350

http://identifiers.org/biomodels.db/MODEL1310110022#_c14b9830_3987_486b_a554_9515a41e1313
is encoded by: hsa:218
initial concentration: NaN
is: P30838
name: ALDH3A1
boundary condition: true
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR UDPG4E
type: Reaction
kinetic law: MODEL1310110022#
product: MODEL1310110022#
is: SBO:0000176
reversible: true
fast: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Galactose metabolism EC Number: 5.1.3.2 Confidence Level: 0 AUTHORS: PMID:11117433 NOTES:used yeast system to overexpress gene to determine mutant kinetic properties
name: UDPglucose 4-epimerase
is version of: http://identifiers.org/ec-code/5.1.3.2
modifier: MODEL1310110022#
reactant: MODEL1310110022#

metaR r2363
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
product: MODEL1310110022#
is: SBO:0000185
reactant: MODEL1310110022#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110022#
name: Organic anion transporter 5 Utilized transport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_cc05e66e_3fff_4edb_bf3d_05b637ea457e
is: P54802
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4669
initial amount: NaN
is: SBO:0000252
name: NAGLU
type: Species
has only substance units: false
constant: false

metaR NDP7g
modifier: MODEL1310110022#
fast: false
kinetic law: MODEL1310110022#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.1.6
is: SBO:0000176
product: MODEL1310110022#
name: nucleoside-diphosphatase (UDP), Golgi apparatus
reactant: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_72386c10_9fa4_44c7_a875_1162330d8b5d
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is: Q9Y3Y1
is encoded by: hsa:65010
initial amount: NaN
boundary condition: true
name: SLC26A6
is: SBO:0000252

metaM ser D c
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB03406
initial amount: NaN
is: CHEBI:16523
type: Species
is: SBO:0000247
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
name: D-serine
constant: false

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

metaR r0788
reversible: true
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
product: MODEL1310110022#
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.15
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_09bdb04b_5151_49eb_8a14_fc792f0e0f80
is: SBO:0000252
is: B7Z6Q4
initial amount: NaN
boundary condition: true
is encoded by: hsa:3612
has only substance units: false
type: Species
initial concentration: NaN
constant: false
name: IMPA1

metaM ksi deg38 l
initial concentration: 1.0
is: SBO:0000247
is: HMDB00143
constant: false
name: keratan sulfate I, degradation product 38
initial amount: NaN
is: CHEBI:12936
type: Species
notes: FORMULA: C54H91N3O41 CHARGE: 0
has only substance units: false
boundary condition: false

metaM fdp c
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00300 EHMN_ABBREVIATION: C00354
is: CHEBI:16905
boundary condition: false
is: http://identifiers.org/pubchem.compound/3647
constant: false
is: HMDB01058
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
is: C00354
name: D-Fructose 1,6-bisphosphate

http://identifiers.org/biomodels.db/MODEL1310110022#_f7f44f8e_6486_4795_9252_ad560c259cbd
is: SBO:0000252
is encoded by: hsa:26266
constant: false
initial amount: NaN
type: Species
is: Q9UKG4
has only substance units: false
boundary condition: true
initial concentration: NaN
name: SLC13A4

metaR ARGtm
name: arginine mitochondrial transport via ornithine carrier
product: MODEL1310110022#
type: Reaction
reversible: true
modifier: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
kinetic law: MODEL1310110022#
is described by: ECO:0000269
fast: false
is: SBO:0000185

metaR BTNPL
is version of: http://identifiers.org/ec-code/6.3.4.10
fast: false
is described by: ECO:0000000
modifier: MODEL1310110022#
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
type: Reaction
reversible: false
name: holocarboxylase synthestase (biotin protein ligase)
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
is: SBO:0000176

metaR r2362
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110022#
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110022#
is: SBO:0000185
reactant: MODEL1310110022#

metaM bilirub e
is: HMDB00054
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:57977
type: Species
initial amount: NaN
boundary condition: false
name: bilirubin(2-)

http://identifiers.org/biomodels.db/MODEL1310110022#_8a534cca_258d_47aa_8c0a_edbdc431d74a
initial amount: NaN
initial concentration: NaN
name: PKM2
constant: false
is: P14618
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5315
boundary condition: true
type: Species

metaR DPMVDc
is described by: ECO:0000134
modifier: MODEL1310110022#
reactant: MODEL1310110022#
name: diphosphomevalonate decarboxylase, cytosol
product: MODEL1310110022#
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (4597.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added t product for elemental balancing.
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.33
reversible: false
type: Reaction
fast: false

metaR HSPGtly
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: heparan sulfate transport, extracellular to lysosome
type: Reaction
product: MODEL1310110022#
is: SBO:0000185
reactant: MODEL1310110022#
reversible: false
kinetic law: MODEL1310110022#

metaR r2526
kinetic law: MODEL1310110022#
reversible: true
reactant: MODEL1310110022#
fast: false
is: SBO:0000185
product: MODEL1310110022#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

metaM ksi deg41 l
is: SBO:0000247
constant: false
is: CHEBI:12936
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C34H58N2O26 CHARGE: 0
name: keratan sulfate I, degradation product 41
initial amount: NaN
is: HMDB00143

metaM triodthy c
name: 3,3',5-triiodo-L-thyronine
boundary condition: false
initial concentration: 1.0
is: CHEBI:18258
is: SBO:0000247
is: HMDB00265
has only substance units: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
initial amount: NaN
constant: false
type: Species

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

metaM dgmp c
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:57673
is: HMDB01044
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
is: SBO:0000247
constant: false
name: dGMP
is: C00362
boundary condition: false
has only substance units: false

metaR r0789
kinetic law: MODEL1310110022#
is described by: ECO:0000000
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
type: Reaction
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
modifier: MODEL1310110022#
reversible: true
product: MODEL1310110022#
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.15
is: SBO:0000176

metaM hxan c
initial amount: NaN
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
is: C00262
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17368
boundary condition: false
is: HMDB00157
type: Species
name: Hypoxanthine

metaR r1669
product: MODEL1310110022#
reactant: MODEL1310110022#
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110022#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110022#
name: Y+LAT2 Utilized transport

metaM dad 2 e
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
is: SBO:0000247
is: CHEBI:17256
boundary condition: false
name: 2-deoxyadenosine
initial amount: NaN
is: HMDB00101
type: Species
constant: false
has only substance units: false
initial concentration: 1.0

metaR RE2626M
is: SBO:0000176
name: RE2626
is version of: http://identifiers.org/ec-code/1.14.13.15
product: MODEL1310110022#
is described by: ECO:0000000
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
fast: false
modifier: MODEL1310110022#
type: Reaction
kinetic law: MODEL1310110022#
reversible: true

metaR GTHPm
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
name: glutathione peroxidase, mitochondria
is version of: http://identifiers.org/ec-code/1.11.1.12
is: SBO:0000176
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
product: MODEL1310110022#
reversible: true
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110022#
fast: false
is version of: http://identifiers.org/ec-code/1.11.1.15

metaR DNDPt9m
is: SBO:0000185
kinetic law: MODEL1310110022#
reversible: false
modifier: MODEL1310110022#
fast: false
name: dADP transport via dTDP antiport
reactant: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
product: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_98589a33_fa0e_4eac_8bb9_49f7dcaf3df6
has only substance units: false
is encoded by: hsa:2720
has part: Q99519
boundary condition: true
is encoded by: hsa:2588
name: GALNS:GLB1:NEU1:CTSA
has part: P34059
type: Species
has part: P10619
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:5476
initial concentration: NaN
is encoded by: hsa:4758
has part: P16278
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_555e958d_d3f9_4e00_ae16_ab20a90ba52b
initial concentration: NaN
is encoded by: hsa:349565
is: Q96T66
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
name: NMNAT3
constant: false

metaM icit m
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
initial amount: NaN
is: SBO:0000247
is: C00311
boundary condition: false
is: HMDB00193
name: Isocitrate
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
is: CHEBI:16087

metaR ASCBt4
name: L-ascorbate transport via proton symport
is described by: ECO:0000269
fast: false
product: MODEL1310110022#
reversible: true
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
reactant: MODEL1310110022#
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
is: SBO:0000185
type: Reaction

metaM hs l
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C79H114N5O102S12 CHARGE: -13
constant: false
name: heparan sulfate, free chain
has only substance units: false
is: CHEBI:28815
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_7fb54d4b_c8bf_4db8_be58_b31c5a2cffa6
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
constant: false
is encoded by: hsa:7360
initial concentration: NaN
is: SBO:0000252
name: UGP2

http://identifiers.org/biomodels.db/MODEL1310110022#_a6efed9e_91e0_4093_aa72_890fc656887d
initial amount: NaN
boundary condition: true
name: AADAT
type: Species
is: SBO:0000252
has only substance units: false
is: Q8N5Z0
constant: false
is encoded by: hsa:51166
initial concentration: NaN

metaR r0990
product: MODEL1310110022#
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000185
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
name: Postulated transport reaction

metaR SUCD1m
product: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000176
fast: false
name: succinate dehydrogenase
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.3.5.1
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
type: Reaction
reversible: true
modifier: MODEL1310110022#

metaR RDH3
fast: false
reversible: true
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
type: Reaction
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368 NOTES:IT
is described by: ECO:0000269
is: SBO:0000176
name: retinol dehydrogenase (11-cis,NADH)
is version of: http://identifiers.org/ec-code/1.1.1.315
modifier: MODEL1310110022#

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

metaM glyc3p x
constant: false
name: Glycerol 3-phosphate
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57597
type: Species
is: SBO:0000247
is: C00093
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: HMDB00126
boundary condition: false

metaR FUMSO4tm
reversible: true
kinetic law: MODEL1310110022#
is: SBO:0000185
name: Fumarate:sulfate antiport, mitochondrial
modifier: MODEL1310110022#
is described by: ECO:0000269
fast: false
product: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reactant: MODEL1310110022#

metaM ipdp c
constant: false
is: HMDB01347
type: Species
is: C00129
boundary condition: false
notes: FORMULA: C5H9O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: Isopentenyl diphosphate
is: CHEBI:128769
initial concentration: 1.0

metaM HC02216 e
constant: false
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
name: prostaglandin-f2beta
is: CHEBI:28922
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaM cholcoa x
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:57373
initial concentration: 1.0
name: choloyl-CoA(4-)
is: HMDB01374
constant: false
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794

metaR r1381
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5
is: SBO:0000176
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
type: Reaction
fast: false
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
is described by: ECO:0000000
reversible: true

metaR r2364
product: MODEL1310110022#
is: SBO:0000185
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_e4cbb867_29e4_4b7f_a3e9_ab80ff5b09ea
initial concentration: NaN
is: P21912
initial amount: NaN
name: SDHB
type: Species
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:6390

metaR r0791
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
product: MODEL1310110022#
reversible: true
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110022#
is: SBO:0000176
fast: false
is described by: ECO:0000000
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_8d433bac_658e_4a05_9b68_d3234f8d21ff
type: Species
boundary condition: true
initial concentration: NaN
name: CA3
has only substance units: false
is: SBO:0000252
is: P07451
initial amount: NaN
is encoded by: hsa:761
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_a85f6297_736c_4cf8_b8e5_47d84594db6c
boundary condition: true
type: Species
is encoded by: hsa:3418
has only substance units: false
constant: false
initial amount: NaN
is: P48735
name: IDH2
is: SBO:0000252
initial concentration: NaN

metaR INSTt4 2
product: MODEL1310110022#
is: SBO:0000185
kinetic law: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD
reactant: MODEL1310110022#
name: inositol transport via sodium symport
is described by: ECO:0000006
fast: false
modifier: MODEL1310110022#
reversible: true

metaM galacglcgalgluside hs g
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
name: Lc4Cer
has only substance units: false
initial concentration: 1.0
is: CHEBI:17103
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
boundary condition: false

metaM cl e
initial amount: NaN
initial concentration: 1.0
type: Species
is: C00115
is: CHEBI:3966
has only substance units: false
name: Chloride
is: HMDB00492
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: Cl CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110022#_54f05e63_0978_4d2d_8ec0_3a3f935b0402
constant: false
name: DLAT
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1737
initial amount: NaN
is: Q86YI5
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110022#_b78896b7_7131_4e6d_b137_1b4a382a4263
is: SBO:0000252
boundary condition: true
has only substance units: false
name: SLC38A1
type: Species
is: Q9H2H9
is encoded by: hsa:81539
initial concentration: NaN
initial amount: NaN
constant: false

metaM prostgh2 c
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
initial amount: NaN
type: Species
constant: false
is: HMDB01381
initial concentration: 1.0
has only substance units: false
is: CHEBI:57405
name: prostaglandin H2(1-)

http://identifiers.org/biomodels.db/MODEL1310110022#_5aa060b7_1446_4cea_bafa_228e634648e7
is encoded by: hsa:2030
boundary condition: true
has only substance units: false
initial concentration: NaN
name: SLC29A1
is: SBO:0000252
initial amount: NaN
constant: false
is: Q99808
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_ef55c39e_8ca3_4a9e_abf0_00fc1f82f85a
boundary condition: true
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
is: Q14542
is encoded by: hsa:3177
initial concentration: NaN
name: SLC29A2

http://identifiers.org/biomodels.db/MODEL1310110022#_3d48bda6_74c5_48ae_b3cc_7ec2fab081f3
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:7355
constant: false
boundary condition: true
name: SLC35A2
has only substance units: false
initial amount: NaN
is: P78381

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

metaR RPE
kinetic law: MODEL1310110022#
reversible: true
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
name: ribulose 5-phosphate 3-epimerase
reactant: MODEL1310110022#
fast: false
product: MODEL1310110022#
is: SBO:0000176
modifier: MODEL1310110022#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/5.1.3.1
type: Reaction

metaM 34dhpac c
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: 3,4-Dihydroxyphenylacetaldehyde
constant: false
has only substance units: false
is: HMDB03791
initial concentration: 1.0
is: CHEBI:27978
type: Species
notes: FORMULA: C8H8O3 CHARGE: 0 INCHI: InChI=1S/C8H8O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,4-5,10-11H,3H2 EHMN_ABBREVIATION: C04043

metaM 5thf e
is: HMDB06487
name: pentaglutamyl folate (THF)
type: Species
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C39H45N11O18 CHARGE: -6
is: SBO:0000247
initial concentration: 1.0

metaR PNP
reversible: true
name: purine-nucleoside phosphorylase
modifier: MODEL1310110022#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: NAD metabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14704851,PMID:9030766 NOTES:IT
reactant: MODEL1310110022#
is: SBO:0000176
kinetic law: MODEL1310110022#
type: Reaction
fast: false
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.4.2.1

metaR r2365
reversible: true
type: Reaction
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
product: MODEL1310110022#
is: SBO:0000185
fast: false
name: Organic anion transporter 5 Utilized transport

metaR r1380
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
fast: false
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
kinetic law: MODEL1310110022#
type: Reaction
product: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000000
reversible: true
is: SBO:0000176

metaM 34dhoxmand c
is: CHEBI:27637
is: HMDB01866
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: 3,4-Dihydroxymandelate
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
constant: false

metaR URATEtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
name: urate export from peroxisome
kinetic law: MODEL1310110022#
fast: false
product: MODEL1310110022#
reversible: false
reactant: MODEL1310110022#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110022#_913f19fc_b725_4d5f_9b13_f40f98ae25e4
initial concentration: NaN
type: Species
is: Q9NYW8
constant: false
name: RBAK
is: SBO:0000252
is encoded by: hsa:57786
boundary condition: true
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_4c7a7fb1_de7a_4318_8412_26d39dfc484b
constant: false
is encoded by: hsa:55967
has only substance units: false
boundary condition: true
is: SBO:0000252
is: F8VQS7
name: NDUFA12
initial concentration: NaN
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_1f3a974b_002c_4fea_928e_6e4d5fcc5a54
initial concentration: NaN
name: _AA081045_1_e
is: SBO:0000252
constant: false
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:AA081045

metaR CYTK11n
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
reactant: MODEL1310110022#
name: cytidylate kinase (dCMP,dGTP),nuclear
product: MODEL1310110022#
fast: false
type: Reaction
is described by: ECO:0000269
reversible: true

metaM glyc e
boundary condition: false
name: Glycerol
constant: false
has only substance units: false
is: SBO:0000247
is: C00116
initial amount: NaN
is: CHEBI:17754
type: Species
initial concentration: 1.0
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: HMDB00131

metaR r2534
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
product: MODEL1310110022#

metaM HC02216 c
initial amount: NaN
name: prostaglandin-f2beta
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:28922
boundary condition: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_9108adeb_eee2_40f0_9891_4435c3e7567c
is: P08559
is: SBO:0000252
constant: false
is encoded by: hsa:5160
has only substance units: false
name: PDHA1
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_e3bfa7ad_fd6a_4d7a_a753_1addb85e9faa
name: SDHB
initial concentration: NaN
type: Species
is encoded by: hsa:6390
constant: false
initial amount: NaN
is: P21912
has only substance units: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110022#_de6d0b0e_bb97_4bd3_a47d_a7a08cf499f5
initial amount: NaN
type: Species
constant: false
name: LDHC
is encoded by: hsa:3948
boundary condition: true
is: P07864
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaM acetone c
boundary condition: false
name: acetone
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:15347
initial concentration: 1.0
is: HMDB01659
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
constant: false

metaM akg c
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: C00026
type: Species
is: HMDB00208
is: CHEBI:16810
constant: false
name: 2-Oxoglutarate
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_0dd8cf9d_7696_4a53_afa0_92ed132ffe03
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:3033
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
is: Q16836
name: HADH

http://identifiers.org/biomodels.db/MODEL1310110022#_b1793d82_96e1_457f_8ef9_b51676d6962e
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:728637
is: SBO:0000252
name: _728637_1_c
type: Species

metaR r2366
kinetic law: MODEL1310110022#
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110022#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110022#
name: Organic anion transporter 5 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110022#_bfd9d0df_e940_4f8d_95f6_5ae2741276f7
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: P56556
has only substance units: false
name: NDUFA6
is encoded by: hsa:4700
constant: false

metaR EX chol LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Choline
type: Reaction

metaM cl c
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
name: Chloride
is: C00115
is: CHEBI:3966
boundary condition: false
is: HMDB00492
notes: FORMULA: Cl CHARGE: -1
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110022#_5fd57d95_c102_4db9_a89a_2a1101f51d2f
name: SLC12A6
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is: Q9UHW9
is encoded by: hsa:9990
constant: false

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

metaR PPCDC
modifier: MODEL1310110022#
fast: false
kinetic law: MODEL1310110022#
reversible: false
is: SBO:0000176
is described by: ECO:0000269
name: phosphopantothenoylcysteine decarboxylase
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 4 AUTHORS: PMID:11923312 NOTES:
is version of: http://identifiers.org/ec-code/4.1.1.36
product: MODEL1310110022#
reactant: MODEL1310110022#
type: Reaction

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

metaR r0993
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14716480,PMID:15209530,PMID:15297262 NOTES:
reactant: MODEL1310110022#
type: Reaction
name: ATP-binding Cassette (ABC) TCDB:3.A.1.208.2
product: MODEL1310110022#
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: false
kinetic law: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_a7313ebe_5339_4353_a00f_537cec41e169
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: TXNRD1
constant: false
is encoded by: hsa:7296

metaR RDH1
name: retinol dehydrogenase (all-trans)
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
fast: false
reversible: true
type: Reaction
is described by: ECO:0000269
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.1.1.315
is: SBO:0000176
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110022#_4727de20_56ca_4085_b899_aae9212a1ee8
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaM prostgh2 e
initial concentration: 1.0
name: prostaglandin H2(1-)
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:57405
type: Species
is: HMDB01381
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427

metaR r2535
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000185
reversible: true
product: MODEL1310110022#
type: Reaction
reactant: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_724f716a_a204_4b35_bf65_993d7cbbb328
constant: false
name: SLC1A4
is encoded by: hsa:6509
type: Species
has only substance units: false
initial amount: NaN
is: P43007
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaM ala L c
boundary condition: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
name: L-alanine
is: CHEBI:16977
is: SBO:0000247
is: HMDB00161
has only substance units: false

metaR r2367
reactant: MODEL1310110022#
name: Organic anion transporter 5 Utilized transport
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110022#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
product: MODEL1310110022#
type: Reaction

metaM galgluside hs g
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:58223
is: SBO:0000247
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
initial concentration: 1.0
name: galactosyl glucosyl ceramide
is: C00015
is: HMDB00295
constant: false
initial amount: NaN

metaM 10fthf e
is: HMDB00972
has only substance units: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
constant: false
name: 10-formyltetrahydrofolate(2-)
initial amount: NaN
boundary condition: false
is: CHEBI:57454
type: Species
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110022#_d98e7965_a30e_430e_9613_aa5903fea820
is: E7EUT4
has only substance units: false
boundary condition: true
type: Species
name: GAPDH
initial concentration: NaN
is encoded by: hsa:2597
constant: false
is: SBO:0000252
initial amount: NaN

metaR r2532
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reversible: true
fast: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110022#
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_4b108ba9_e470_493e_8ce7_c4ac60344df3
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: Q7GXZ8
initial amount: NaN
is encoded by: hsa:4513
boundary condition: true
constant: false
name: COX2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_90715a07_8fd1_49f8_bcf0_3475b934e362
constant: false
is encoded by: hsa:AI656480
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
name: _AI656480_1_m
initial amount: NaN

metaR r0994
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
reactant: MODEL1310110022#
is described by: ECO:0000000
reversible: true
product: MODEL1310110022#
is: SBO:0000185
kinetic law: MODEL1310110022#
name: Facilitated diffusion
fast: false

metaR CMPACNAtg
modifier: MODEL1310110022#
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110022#
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD
type: Reaction
name: CMP-Sia Golgi transport via CMP antiport

metaR CERT1gt
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
is described by: ECO:0000304
reversible: true
name: ceramide transport protein
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.7.11.1
product: MODEL1310110022#
type: Reaction
fast: false
modifier: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_84b30523_c45c_47f4_b0de_0451b1be0da9
is: SBO:0000252
name: FOLR1
has only substance units: false
is encoded by: hsa:2348
type: Species
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN

metaM thym m
initial concentration: 1.0
type: Species
notes: FORMULA: C5H6N2O2 CHARGE: 0 INCHI: InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
name: thymine
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB00262
is: CHEBI:17821
has only substance units: false

metaM acetone e
constant: false
initial concentration: 1.0
is: HMDB01659
is: CHEBI:15347
initial amount: NaN
type: Species
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
name: acetone
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR r2368
type: Reaction
reactant: MODEL1310110022#
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110022#
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110022#

metaR r0795
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Unassigned EC Number: 1.5.1.20 Confidence Level: 0 AUTHORS: PMID:1119805,PMID:2383427 NOTES:
kinetic law: MODEL1310110022#
name: Spontaneous reaction
modifier: MODEL1310110022#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.225
type: Reaction
reversible: false
reactant: MODEL1310110022#
product: MODEL1310110022#
fast: false

metaR r1671
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110022#
type: Reaction
reactant: MODEL1310110022#
product: MODEL1310110022#
fast: false
modifier: MODEL1310110022#

metaR GLXO2p
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
reversible: false
type: Reaction
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.1.3.15
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (54363.1) or (51179.2) or (51179.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.3.15 Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:NCD
is: SBO:0000176
fast: false
name: glyoxylate oxidase, peroxisomal
product: MODEL1310110022#

metaM C02528 r
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
type: Species
name: chenodeoxycholate
is: CHEBI:36234
is: HMDB00518
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_c5d67656_e310_4c30_922d_53dcbff11e34
type: Species
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AA278423
name: _AA278423_1_c
has only substance units: false
is: SBO:0000252

metaM atp x
constant: false
name: ATP(4-)
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB00538
initial concentration: 1.0
is: CHEBI:57299
type: Species
is: C00002
has only substance units: false

metaR r1451
reversible: false
product: MODEL1310110022#
name: EC:1.3.3.6
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
kinetic law: MODEL1310110022#
type: Reaction
reactant: MODEL1310110022#
is: SBO:0000176
fast: false

metaM co2 r
name: CO2
has only substance units: false
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: C00011
is: SBO:0000247
is: CHEBI:16526
constant: false
type: Species
is: HMDB01967

metaR EX orot LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of orotate
type: Reaction

metaR r0074
fast: false
reversible: true
product: MODEL1310110022#
reactant: MODEL1310110022#
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
is version of: http://identifiers.org/ec-code/6.2.1.1
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110022#_59159406_a45c_4ab3_829a_78c33c26f77f
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:3948
initial concentration: NaN
name: LDHC
constant: false
boundary condition: true
is: P07864

metaR 5MTHFt2le
name: 5-methyltetrahydrofolate transport via anion exchange
is described by: ECO:0000134
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110022#
is: SBO:0000185
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110022#

metaR SIAASE4ly
reactant: MODEL1310110022#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.2.1.23
name: sialidase, lysosomal
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110022#
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5

http://identifiers.org/biomodels.db/MODEL1310110022#_2163b766_ae60_40a9_8cc0_50dbb601ceb5
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:NM 013421
boundary condition: true
constant: false
has only substance units: false
type: Species
name: _NM_013421_1_e

http://identifiers.org/biomodels.db/MODEL1310110022#_d26fb012_dd81_4606_a931_1e1c1a421bcf
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:4717
boundary condition: true
is: O43677
has only substance units: false
initial amount: NaN
name: NDUFC1

metaM ksi deg4 l
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00868
name: keratan sulfate I, degradation product 4
is: CHEBI:57737
notes: FORMULA: C222H355N15O197S12 CHARGE: -12
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110022#_7b82fc3b_8226_47c2_8e4b_0649227aa150
type: Species
initial concentration: NaN
name: _H77542_1_r
has only substance units: false
is: SBO:0000252
is encoded by: hsa:H77542
initial amount: NaN
boundary condition: true
constant: false

metaR DHFR
modifier: MODEL1310110022#
name: dihydrofolate reductase
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/1.5.1.3
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110022#
is: SBO:0000176
product: MODEL1310110022#
reactant: MODEL1310110022#
reversible: true

metaR MAL Lte
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
product: MODEL1310110022#
name: Transport of L-malate
fast: false
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
is described by: ECO:0000134

metaR CPPPGO
notes: GENE_ASSOCIATION: (1371.1) SUBSYSTEM: Heme synthesis EC Number: 1.3.3.3 Confidence Level: 2 AUTHORS: PMID:8407975 NOTES:r0608, JLR
fast: false
product: MODEL1310110022#
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.3.3.3
reactant: MODEL1310110022#
is described by: ECO:0000304
is: SBO:0000176
modifier: MODEL1310110022#
type: Reaction
name: coproporphyrinogen oxidase (O2 required)
reversible: false

metaR r2369
fast: false
is: SBO:0000185
product: MODEL1310110022#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
reactant: MODEL1310110022#
name: Organic anion transporter 5 Utilized transport
type: Reaction
kinetic law: MODEL1310110022#

metaM accoa c
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
constant: false
is: CHEBI:57288
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB01206
is: C00024
type: Species
name: Acetyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110022#_1b562c5e_ba06_48a8_9eb7_8aedb83a387a
has part: Q02221
has part: P12074
is encoded by: hsa:84701
is encoded by: hsa:9377
has part: H0UI06
is encoded by: hsa:1349
is encoded by: hsa:125965
has part: Q6YFQ2
has part: P24311
is encoded by: hsa:4514
is encoded by: hsa:1337
is encoded by: hsa:1346
is encoded by: hsa:1340
is encoded by: hsa:341947
has part: P13073
has part: P09669
initial amount: NaN
is encoded by: hsa:9167
has part: Q7Z4L0
is: SBO:0000297
has part: P15954
has part: Q7GXY8
has part: Q53XN1
initial concentration: NaN
has part: P20674
has part: P24310
constant: false
has part: Q96KJ9
is encoded by: hsa:4512
has part: P14854
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
is encoded by: hsa:1347
boundary condition: true
has part: Q8TF08
has only substance units: false
is encoded by: hsa:1327
is encoded by: hsa:1350
is encoded by: hsa:1329
is encoded by: hsa:1339
has part: Q53YB7
is encoded by: hsa:4513
type: Species
has part: Q6FGA0
has part: P00414
is encoded by: hsa:1345
is encoded by: hsa:170712
is encoded by: hsa:1351
has part: Q7GXZ8

metaR PPNCL3
kinetic law: MODEL1310110022#
is: SBO:0000176
reactant: MODEL1310110022#
modifier: MODEL1310110022#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (79717.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110022#
reversible: false
name: phosphopantothenate-cysteine ligase
is version of: http://identifiers.org/ec-code/6.3.2.5
fast: false

metaR r1672
product: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: false
is: SBO:0000185
modifier: MODEL1310110022#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#

metaR r0680
kinetic law: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
is: SBO:0000176
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is described by: ECO:0000000
reactant: MODEL1310110022#
product: MODEL1310110022#
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.3.1.137
reversible: true
type: Reaction

metaM ala L e
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
type: Species
boundary condition: false
initial amount: NaN
is: HMDB00161
name: L-alanine
is: CHEBI:16977
initial concentration: 1.0
is: SBO:0000247
constant: false

metaM HC02121 c
constant: false
type: Species
boundary condition: false
name: S-(hydroxymethyl)glutathione(1-)
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180
is: CHEBI:58758
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaM 10fthf c
constant: false
is: C00234
name: 10-Formyltetrahydrofolate
is: HMDB00972
is: CHEBI:57454
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
initial amount: NaN

metaR RPI
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
is version of: http://identifiers.org/ec-code/5.3.1.6
name: ribose-5-phosphate isomerase
kinetic law: MODEL1310110022#
is: SBO:0000176
reactant: MODEL1310110022#
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110022#

metaR CGLYt3 2
modifier: MODEL1310110022#
reversible: false
is: SBO:0000185
name: Cys-Gly transport in via proton symport
is described by: ECO:0000304
fast: false
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB
type: Reaction
reactant: MODEL1310110022#
product: MODEL1310110022#
kinetic law: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_039e7144_9e68_4f3e_9337_ba497170054c
boundary condition: true
is: SBO:0000252
is encoded by: hsa:LOC374569
type: Species
name: _LOC374569_1_e
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN

metaR r1947
product: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110022#
reversible: false
is: SBO:0000185
type: Reaction
modifier: MODEL1310110022#
is described by: ECO:0000000

metaR B MANNASEly
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110022#
reversible: false
name: beta-mannosidase, lysosomal
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (4126.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.25 Confidence Level: 0 AUTHORS: PMID:9384606 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.25
kinetic law: MODEL1310110022#
product: MODEL1310110022#
is: SBO:0000176

metaM thbpt4acam c
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB02281
name: 4a-hydroxytetrahydrobiopterin
is: SBO:0000247
is: CHEBI:15374
boundary condition: false
constant: false
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_2d2396a4_e8c2_4ca3_8480_25a38723cf0d
is: O95497
is encoded by: hsa:8876
is: SBO:0000252
initial amount: NaN
type: Species
name: VNN1
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110022#_237f63c5_e2aa_47b7_aa71_8db3d1a7ef39
has only substance units: false
type: Species
name: CHAT
initial concentration: NaN
is encoded by: hsa:1103
boundary condition: true
is: D3DX95
initial amount: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_3ccdeae7_5724_49b3_82ab_630f237f5ad7
name: ALDH3B2
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:222
is: P48448
constant: false

metaM dump c
constant: false
is: HMDB01409
name: dUMP
has only substance units: false
is: C00365
type: Species
is: CHEBI:246422
is: SBO:0000247
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
initial concentration: 1.0
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_32d6950e_1814_47e0_9453_09ba44162a83
boundary condition: true
is: SBO:0000252
is encoded by: hsa:22978
name: NT5C2
type: Species
has only substance units: false
is: P49902
constant: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_6c102d29_bc95_492f_bf75_1bc91b35b1f2
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6647
initial concentration: NaN
is: P00441
boundary condition: true
type: Species
constant: false
initial amount: NaN
name: SOD1

metaR RE2677E
kinetic law: MODEL1310110022#
name: RE2677
reactant: MODEL1310110022#
product: MODEL1310110022#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:IT - fixed proton
reversible: false
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110022#_be8e7f8b_6b6e_43cb_bcf8_5685987d4bd0
is: SBO:0000252
constant: false
name: AKR1A1
is encoded by: hsa:10327
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_40b2a625_7f68_4536_beb1_65c1d2468029
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
name: EHHADH
constant: false
initial amount: NaN
is encoded by: hsa:1962
is: Q9NY65

metaR EX 7dhf LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (DHF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_64ce7b27_160d_498a_bbf8_2c54e31b2a77
has only substance units: false
is: P22304
initial amount: NaN
initial concentration: NaN
name: IDS
boundary condition: true
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:3423

metaR PEt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:
name: phosphatidylethanolamine transport
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
fast: false
product: MODEL1310110022#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110022#_6e632ec8_6332_4da9_ad04_44f7a95e433c
initial concentration: NaN
boundary condition: true
constant: false
name: SLC6A5
type: Species
is encoded by: hsa:9152
is: Q9Y345
has only substance units: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110022#_be747dd7_edc3_4c5f_b10f_d145b8f61277
is: SBO:0000252
is: Q02318
initial concentration: NaN
name: CYP27A1
type: Species
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:1593

metaR PAIL45P HStn
fast: false
is described by: ECO:0000000
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
reversible: true
kinetic law: MODEL1310110022#
is: SBO:0000185
product: MODEL1310110022#
reactant: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:

metaM dcholcoa r
initial amount: NaN
has only substance units: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
is: HMDB06292
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28701
constant: false
type: Species
name: chenodeoxycholoyl coenzyme a

http://identifiers.org/biomodels.db/MODEL1310110022#_f85b5e5d_1dc7_4169_a81e_98f38b4242c9
boundary condition: true
is encoded by: hsa:R39999
type: Species
constant: false
has only substance units: false
initial amount: NaN
name: _R39999_1_c
initial concentration: NaN
is: SBO:0000252

metaM for r
is: HMDB00142
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:15740
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
name: Formate
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: C00058
type: Species

metaM xol7ah2al c
is: HMDB06894
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
initial amount: NaN
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
is: CHEBI:27428
initial concentration: 1.0
constant: false

metaR CREATt4 2 r
name: Creatine transport (sodium symport) (2:1)
is: SBO:0000185
kinetic law: MODEL1310110022#
product: MODEL1310110022#
modifier: MODEL1310110022#
is described by: ECO:0000269
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reversible: true
reactant: MODEL1310110022#

metaR r1450
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
is described by: ECO:0000000
product: MODEL1310110022#
type: Reaction
is: SBO:0000176
reversible: false
fast: false
reactant: MODEL1310110022#
name: EC:1.3.3.6

http://identifiers.org/biomodels.db/MODEL1310110022#_f7cd555c_9a95_4263_8e8f_1721ee601368
name: COX6C
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
boundary condition: true
is: P09669
is encoded by: hsa:1345
initial concentration: NaN
has only substance units: false

metaR ALAt2r
is: SBO:0000185
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
product: MODEL1310110022#
modifier: MODEL1310110022#
is described by: ECO:0000304
type: Reaction
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
fast: false
reversible: true
name: L-alanine reversible transport via proton symport

metaR G6Pter
product: MODEL1310110022#
reversible: true
notes: GENE_ASSOCIATION: (2542.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11032333,PMID:11140953,PMID:11879177,PMID:9428641 NOTES:NCD
fast: false
modifier: MODEL1310110022#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110022#
name: glucose 6-phosphate endoplasmic reticular transport via diffusion
is described by: ECO:0000269
reactant: MODEL1310110022#

metaM thbpt4acam n
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB02281
name: 4a-hydroxytetrahydrobiopterin
type: Species
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
initial amount: NaN
is: CHEBI:15374
is: SBO:0000247

metaM cmp n
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
is: HMDB00095
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
initial amount: NaN
name: CMP(2-)
is: CHEBI:60377
boundary condition: false
is: SBO:0000247

metaR LDH L
reactant: MODEL1310110022#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
reversible: true
name: L-lactate dehydrogenase
modifier: MODEL1310110022#
is: SBO:0000176
product: MODEL1310110022#
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.1.1.27
fast: false

metaR DTTPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: true
name: dTTP diffusion in nucleus
is described by: ECO:0000000
product: MODEL1310110022#
fast: false
type: Reaction
kinetic law: MODEL1310110022#
is: SBO:0000185
reactant: MODEL1310110022#

metaR r0570
kinetic law: MODEL1310110022#
fast: false
type: Reaction
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
is: SBO:0000176
reactant: MODEL1310110022#
reversible: true
product: MODEL1310110022#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.3.3.2
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:

metaM dhap c
initial amount: NaN
name: Dihydroxyacetone phosphate
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/3411
is: C00111
constant: false
is: HMDB01473
has only substance units: false
initial concentration: 1.0
is: CHEBI:57642
boundary condition: false

metaR RNDR1
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
reactant: MODEL1310110022#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.17.4.1
product: MODEL1310110022#
reversible: false
kinetic law: MODEL1310110022#
is described by: ECO:0000254
modifier: MODEL1310110022#
type: Reaction
name: ribonucleoside-diphosphate reductase (ADP)

metaR DOPAt4 2 r
product: MODEL1310110022#
fast: false
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110022#
is: SBO:0000185
name: Dopamine reversible transport in via sodium symport (1:2)
reactant: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
kinetic law: MODEL1310110022#

metaR NADtru
product: MODEL1310110022#
kinetic law: MODEL1310110022#
reversible: false
fast: false
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
name: NAD transporter, endoplasmic reticulum

http://identifiers.org/biomodels.db/MODEL1310110022#_761d77af_38dc_4373_a4da_dc63bc13e79a
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
name: ALDH7A1
is: SBO:0000252
is: E7EPT3
has only substance units: false
boundary condition: true
is encoded by: hsa:501

http://identifiers.org/biomodels.db/MODEL1310110022#_54461988_65d6_43bb_9076_81776ce515fe
name: ATP2B1
constant: false
type: Species
is encoded by: hsa:490
initial amount: NaN
is: P20020
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR URIt
product: MODEL1310110022#
is described by: ECO:0000269
modifier: MODEL1310110022#
is: SBO:0000185
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
reactant: MODEL1310110022#
fast: false
type: Reaction
name: uridine facilated transport in cytosol
reversible: true

metaR r0425
is described by: ECO:0000000
modifier: MODEL1310110022#
type: Reaction
kinetic law: MODEL1310110022#
name: EC:1.1.1.42
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:18484410,PMID:9866202 NOTES:
reactant: MODEL1310110022#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.17.1.4
product: MODEL1310110022#
fast: false
reversible: true

metaR RADH
fast: false
type: Reaction
name: retinal dehydrogenase
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reversible: true
reactant: MODEL1310110022#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110022#
kinetic law: MODEL1310110022#

metaM dhcrm hs c
initial amount: NaN
is: CHEBI:31488
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126
has only substance units: false
name: dihydroceramide
type: Species
is: SBO:0000247

metaR r2008
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
fast: false
type: Reaction
reversible: false
reactant: MODEL1310110022#
product: MODEL1310110022#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000

metaR r0998
name: Facilitated diffusion
fast: false
reversible: true
reactant: MODEL1310110022#
is described by: ECO:0000000
kinetic law: MODEL1310110022#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
type: Reaction
product: MODEL1310110022#

metaM sql r
is: SBO:0000247
initial amount: NaN
name: squalene
type: Species
is: CHEBI:15440
is: HMDB00256
boundary condition: false
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
initial concentration: 1.0
constant: false
has only substance units: false

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

metaM co2 m
initial concentration: 1.0
is: C00011
is: SBO:0000247
name: CO2
has only substance units: false
is: CHEBI:16526
boundary condition: false
constant: false
type: Species
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
initial amount: NaN
is: HMDB01967

metaR MMEm
is version of: http://identifiers.org/ec-code/5.1.99.1
product: MODEL1310110022#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (84693.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.1.99.1 Confidence Level: 4 AUTHORS: PMID:11481338 NOTES:TDV
type: Reaction
reactant: MODEL1310110022#
name: methylmalonyl-CoA epimerase/racemase
fast: false
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#

metaM hs deg5 l
boundary condition: false
has only substance units: false
name: heparan sulfate, degradation product 5
is: CHEBI:17895
initial concentration: 1.0
type: Species
notes: FORMULA: C67H97N4O86S10 CHARGE: -11
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB00158

metaR GALASE16ly
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110022#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110022#_e05f51d0_ef83_472a_8fe2_98e61e7cbc98
initial concentration: NaN
initial amount: NaN
name: HSD3B2
is: SBO:0000252
is encoded by: hsa:3284
boundary condition: true
type: Species
is: P26439
has only substance units: false
constant: false

metaR PTPATe
is described by: ECO:0000134
is: SBO:0000176
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110022#
name: PTPATe
reversible: true
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110022#_c48695fd_7b3a_4836_95e8_167b68c38612
name: SLC4A8
type: Species
is: E7EML0
has only substance units: false
is encoded by: hsa:9498
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR RE2649C
type: Reaction
is described by: ECO:0000000
name: RE2649
is: SBO:0000176
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.1.2.2
modifier: MODEL1310110022#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.65
product: MODEL1310110022#

metaM ksi deg23 l
boundary condition: false
initial amount: NaN
type: Species
name: keratan sulfate I, degradation product 23
is: HMDB00143
is: CHEBI:12936
initial concentration: 1.0
notes: FORMULA: C124H201N8O106S5 CHARGE: -5
has only substance units: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_fb64a8b0_76fa_4f13_99f7_2fa957855a87
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
name: LDHAL6B
is encoded by: hsa:92483
is: Q9BYZ2
constant: false
is: SBO:0000252
type: Species

metaM glcur c
name: D-glucuronate
initial amount: NaN
is: HMDB00127
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
type: Species
is: CHEBI:15748
initial concentration: 1.0

metaR r0426
type: Reaction
product: MODEL1310110022#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
reversible: true
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
kinetic law: MODEL1310110022#
is described by: ECO:0000000
reactant: MODEL1310110022#
modifier: MODEL1310110022#
is version of: http://identifiers.org/ec-code/1.5.1.34

metaR CH25H
modifier: MODEL1310110022#
fast: false
product: MODEL1310110022#
name: cholesterol 25-hydroxylase
is described by: ECO:0000269
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.99.38
type: Reaction
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (9023.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110022#

metaR r0999
type: Reaction
kinetic law: MODEL1310110022#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
product: MODEL1310110022#
name: Facilitated diffusion
reactant: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_ad77cb05_71ba_489d_a9b1_4bafa482a154
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
name: RRM1
is: SBO:0000252
initial concentration: NaN
is: P23921
type: Species
is encoded by: hsa:6240

metaM utp n
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
name: UTP(4-)
has only substance units: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: HMDB00285
constant: false
is: CHEBI:46398

metaR CITtbm
reactant: MODEL1310110022#
is: SBO:0000185
kinetic law: MODEL1310110022#
type: Reaction
name: citrate transport, mitochondrial
modifier: MODEL1310110022#
reversible: true
is described by: ECO:0000269
fast: false
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with PEP IF

metaR FPGS7m
is: SBO:0000176
reactant: MODEL1310110022#
fast: false
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.3.2.17
product: MODEL1310110022#
reversible: false
kinetic law: MODEL1310110022#
name: folylpolyglutamate synthetase (10fthf), mitochondrial
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110022#_397ffbc0_81f5_401d_8454_49c36d0116ad
is encoded by: hsa:6482
is: Q11201
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
name: ST3GAL1
constant: false
has only substance units: false
boundary condition: true

metaR r1453
reversible: true
reactant: MODEL1310110022#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
product: MODEL1310110022#
kinetic law: MODEL1310110022#
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
fast: false
type: Reaction
is: SBO:0000176

metaM glu5sa m
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
has only substance units: false
is: CHEBI:17232
initial concentration: 1.0
name: L-Glutamate 5-semialdehyde
is: C01165
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB02104
type: Species
constant: false

metaM dgtp n
type: Species
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: C00286
is: HMDB01440
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:16497
has only substance units: false
name: dGTP
boundary condition: false
is: SBO:0000247

metaR NACHEX10ly
reversible: false
product: MODEL1310110022#
reactant: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110022#
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110022#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_82c3e1bb_ad97_4c28_b723_a5864dcff059
constant: false
is encoded by: hsa:AA629629
boundary condition: true
initial amount: NaN
name: _AA629629_1_m
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_a63b52f0_10a9_404d_b7a6_ef25e75975de
is: SBO:0000252
is encoded by: hsa:25902
type: Species
name: MTHFD1L
is: B2RD24
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110022#_7048a562_16e2_4e2f_897f_f2a3c9574822
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:4708
name: NDUFB2
constant: false
initial amount: NaN
is: H7C5B8
is: SBO:0000252

metaR TAURCHAe
is: SBO:0000185
kinetic law: MODEL1310110022#
type: Reaction
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14992263 NOTES:taurine is an osmolyte that aids in osmoregulation. Reactive oxygen species (ROS) and eicosanoids activate tyrosine-kinase cascade, resulting in activation of volume sensitive taurine channel. Further ROS causes membrane permeabilization that results in taruine loss.
reversible: false
fast: false
product: MODEL1310110022#
name: exit of taurine from the enterocytes
is described by: ECO:0000134

metaM icit c
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB00193
initial amount: NaN
name: Isocitrate
is: C00311
is: CHEBI:16087
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110022#_25ea2e6f_d866_4e2f_ab7f_d30d0037a532
is: Q99714
name: HSD17B10
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:3028

metaR EX ha LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan exchange
type: Reaction

metaR NADtx
type: Reaction
product: MODEL1310110022#
is: SBO:0000185
name: transport of NAD into peroxisome
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#

metaM thym c
initial amount: NaN
has only substance units: false
is: CHEBI:17821
initial concentration: 1.0
is: C00178
is: SBO:0000247
name: Thymine
notes: FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
is: HMDB00262
boundary condition: false
type: Species
constant: false

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

metaR 34DHXMANDACOX NADP
reactant: MODEL1310110022#
product: MODEL1310110022#
reversible: true
is described by: ECO:0000269
type: Reaction
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (221.1) or (222.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110022#_92eea796_1c1f_42e6_a4d4_c919000ac6ce
name: PGM1
constant: false
type: Species
is: B4DPV0
is encoded by: hsa:5236
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR CHSTEROLtrc
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
fast: false
is: SBO:0000185
is described by: ECO:0000134
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
product: MODEL1310110022#
name: transport of cholesterol into the cytosol
type: Reaction
reversible: true

metaR S3TASE3ly
kinetic law: MODEL1310110022#
fast: false
is described by: ECO:0000000
name: N-acetylglucosamine-3-sulfatase, lysosomal
product: MODEL1310110022#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 2 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110022#
type: Reaction

metaR GUAt
modifier: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR
fast: false
name: Guanine transport
reversible: true
type: Reaction
is: SBO:0000185
product: MODEL1310110022#
is described by: ECO:0000269
kinetic law: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_3499c5b2_799e_4074_a636_3e35d51dff2c
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: DGKI
constant: false
has only substance units: false
is encoded by: hsa:9162
is: O75912
boundary condition: true

metaR r1670
reversible: true
name: Y+LAT2 Utilized transport
type: Reaction
kinetic law: MODEL1310110022#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110022#
is described by: ECO:0000000
product: MODEL1310110022#
fast: false
reactant: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_0a18af71_909f_4209_a474_2a8185801a05
is: SBO:0000252
name: BTD
boundary condition: true
has only substance units: false
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:686
initial concentration: NaN
is: P43251

metaR PSSA1 hs
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.8.29
product: MODEL1310110022#
name: Phosphatidylserine synthase homo sapiens
reactant: MODEL1310110022#
fast: false
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (9791.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylcholine as substrate NJ
reversible: true
is: SBO:0000176

metaM glcur e
initial amount: NaN
is: HMDB00127
is: SBO:0000247
constant: false
name: D-glucuronate
boundary condition: false
type: Species
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
has only substance units: false
is: CHEBI:15748
initial concentration: 1.0

metaM CE5854 e
boundary condition: false
type: Species
is: HMDB02710
name: gama-CEHC-glucuronide
has only substance units: false
is: SBO:0000247
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
initial concentration: 1.0
is: CHEBI:27485
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_68a7b06d_ff99_4541_88fb_6e90a527c3d2
boundary condition: true
name: _AU149534_1_c
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
constant: false
is encoded by: hsa:AU149534

metaR GALtly
product: MODEL1310110022#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110022#
reversible: false
fast: false
reactant: MODEL1310110022#
name: galactose efflux from lysosome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110022#_724f1bd0_dfda_48d4_84d5_b033a68c852f
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2990
is: P08236
has only substance units: false
initial amount: NaN
name: GUSB
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110022#_88de09ba_5f39_45f7_a454_02b0d0f4d750
has only substance units: false
name: _AI935189_1_m
is: SBO:0000252
is encoded by: hsa:AI935189
type: Species
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaR UDPACGALtl
is: SBO:0000185
fast: false
reactant: MODEL1310110022#
reversible: true
type: Reaction
product: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - there are UDPACGAL-translocators for ER and Golgi, however no info on lysosomal - poor support for this NJ
is described by: ECO:0000000
kinetic law: MODEL1310110022#
name: udpacgal intracellular transport

metaR r2005
type: Reaction
reversible: false
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
is: SBO:0000185

metaM glyc c
type: Species
name: Glycerol
initial amount: NaN
is: SBO:0000247
is: HMDB00131
constant: false
has only substance units: false
initial concentration: 1.0
is: C00116
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
boundary condition: false
is: CHEBI:17754

http://identifiers.org/biomodels.db/MODEL1310110022#_ccaac4b6_5699_4858_ae9c_e9d765b5ec0a
is: SBO:0000252
initial amount: NaN
name: ENTPD8
type: Species
is encoded by: hsa:377841
is: Q5MY95
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_cbd35cbe_b3a3_48b9_8f6a_ca8d7f2e0601
has part: P55084
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:3032
initial concentration: NaN
is encoded by: hsa:3030
name: HADHA:HADHB
constant: false
has part: E9KL44
is: SBO:0000297
type: Species

metaR r0377
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
is version of: http://identifiers.org/ec-code/2.7.4.3
is: SBO:0000176
reactant: MODEL1310110022#
type: Reaction
fast: false
is described by: ECO:0000000
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
reversible: false

metaR RE0958E
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
fast: false
modifier: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000176
kinetic law: MODEL1310110022#
is described by: ECO:0000000
name: RE0958
is version of: http://identifiers.org/ec-code/3.2.1.17
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.2.1.1
type: Reaction
reversible: true

metaR UPPN
is version of: http://identifiers.org/ec-code/3.5.1.6
name: b-ureidopropionase
modifier: MODEL1310110022#
reversible: false
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:10542323,PMID:12450676 NOTES:SAB balanced
is: SBO:0000176
fast: false
kinetic law: MODEL1310110022#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110022#
reactant: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_2f381fd2_dabb_40b7_b949_d90ade3eb2ff
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: COL4A3BP
is encoded by: hsa:10087
boundary condition: true
type: Species
is: Q9Y5P4
initial amount: NaN
constant: false

metaR RETI1
name: retinol isomerase (11-cis)
product: MODEL1310110022#
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000176
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
is described by: ECO:0000000

metaR HSAT3ly
kinetic law: MODEL1310110022#
product: MODEL1310110022#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
reactant: MODEL1310110022#
name: heparan-glucosaminide N-acetyltransferase, lysosomal
fast: false
is: SBO:0000185
is described by: ECO:0000000

metaM nad c
is: C00003
is: http://identifiers.org/pubchem.compound/3305
initial concentration: 1.0
has only substance units: false
is: HMDB00902
type: Species
is: CHEBI:57540
name: Nicotinamide adenine dinucleotide
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false

metaR SPHK21c
fast: false
modifier: MODEL1310110022#
reactant: MODEL1310110022#
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.7.1.91
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NJ
product: MODEL1310110022#
is described by: ECO:0000269
name: sphingosine kinase 2
reversible: false

metaM g6p c
initial amount: NaN
type: Species
is: CHEBI:61548
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB01401
is: C00092
initial concentration: 1.0
name: D-Glucose 6-phosphate
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110022#_a78cdacc_19d8_4e3d_978c_eff36065db9c
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1329
type: Species
constant: false
name: COX5B
initial concentration: NaN
is: Q53YB7

http://identifiers.org/biomodels.db/MODEL1310110022#_28393d58_7c3c_47b9_8bbb_67e58a21c459
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
name: ALDH3A2
is encoded by: hsa:224
is: P51648

metaM cala c
initial amount: NaN
type: Species
name: N-carbamoyl-beta-alaninate
boundary condition: false
is: SBO:0000247
notes: FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB00026
is: CHEBI:11892

http://identifiers.org/biomodels.db/MODEL1310110022#_99905330_d745_430c_a133_2b7bf3920389
constant: false
has only substance units: false
is: P36269
is encoded by: hsa:2687
initial concentration: NaN
name: GGT5
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR r0575
reactant: MODEL1310110022#
product: MODEL1310110022#
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.48
is described by: ECO:0000000
reversible: true
type: Reaction

metaR r0422
kinetic law: MODEL1310110022#
type: Reaction
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
reactant: MODEL1310110022#
is: SBO:0000176
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
product: MODEL1310110022#
fast: false
modifier: MODEL1310110022#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110022#_7d3eef7e_67b9_4e76_be93_d9eddb9b3aec
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q8N9L9
name: ACOT4
is encoded by: hsa:122970
has only substance units: false
is: SBO:0000252

metaM mi1345p c
is: SBO:0000247
is: HMDB01059
has only substance units: false
initial amount: NaN
is: CHEBI:57895
constant: false
boundary condition: false
notes: FORMULA: C6H8O18P4 CHARGE: -8 INCHI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/p-8/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C01272
name: 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
initial concentration: 1.0
type: Species

metaR NAGA2ly
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
modifier: MODEL1310110022#
is described by: ECO:0000000
product: MODEL1310110022#
is version of: http://identifiers.org/ec-code/3.2.1.49
fast: false
kinetic law: MODEL1310110022#
name: N-acetylgalactosaminidase, alpha-
type: Reaction
reactant: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_a25fc4ab_6107_4648_85ed_397b4d32eb34
initial amount: NaN
boundary condition: true
is: Q9HAS3
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: SLC28A3
type: Species
constant: false
is encoded by: hsa:64078

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110022#
reactant: MODEL1310110022#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

metaM atp r
constant: false
is: CHEBI:57299
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB00538
has only substance units: false
is: C00002
name: ATP(4-)
initial amount: NaN

metaM dtdp m
name: dTDP
is: C00363
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: CHEBI:58369
boundary condition: false
is: HMDB01274
initial amount: NaN
has only substance units: false
constant: false

metaR THFtm
type: Reaction
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
is: SBO:0000185
kinetic law: MODEL1310110022#
is described by: ECO:0000000
reactant: MODEL1310110022#
reversible: true
product: MODEL1310110022#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110022#_f8630720_f12b_4332_98e5_e9e5bdfc4f23
initial amount: NaN
initial concentration: NaN
name: NDUFS2
is: SBO:0000252
has only substance units: false
is: B7Z792
type: Species
boundary condition: true
is encoded by: hsa:4720
constant: false

metaR P5CR
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 4 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:
kinetic law: MODEL1310110022#
product: MODEL1310110022#
reactant: MODEL1310110022#
is: SBO:0000176
name: pyrroline-5-carboxylate reductase
reversible: false
is described by: ECO:0000134

metaR r0423
is described by: ECO:0000000
reactant: MODEL1310110022#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
type: Reaction
modifier: MODEL1310110022#
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
product: MODEL1310110022#
is: SBO:0000176
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:

metaR r2028
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110022#
kinetic law: MODEL1310110022#
reversible: false
product: MODEL1310110022#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110022#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110022#_e6aae6b7_0e41_4034_9696_600472e9c2fb
is: P49753
has only substance units: false
is encoded by: hsa:10965
name: ACOT2
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
type: Species

metaR SO4OXAtex2
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
is: SBO:0000185
reversible: false
reactant: MODEL1310110022#
fast: false
is described by: ECO:0000304
modifier: MODEL1310110022#
type: Reaction
kinetic law: MODEL1310110022#
name: sulfate transport via oxalate countertransport (2:1)
product: MODEL1310110022#

http://identifiers.org/biomodels.db/MODEL1310110022#_db5621ad_d86d_408b_bcbe_d359f47ecb80
type: Species
has only substance units: false
is encoded by: hsa:6524
is: P31639
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: SLC5A2
constant: false

metaR ACACt2
reactant: MODEL1310110022#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
name: acetoacetate transport via proton symport
product: MODEL1310110022#
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110022#
modifier: MODEL1310110022#
type: Reaction

metaR LINKDEG1ly
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
reactant: MODEL1310110022#
name: degradation of proteoglycan linkage region, lysosomal
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110022#
product: MODEL1310110022#
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110022#_4d54b146_0718_473c_bdc7_0dd217506ef4
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
is: Q9NVS9
initial concentration: NaN
type: Species
is: SBO:0000252
name: PNPO
is encoded by: hsa:55163

metaR r2001
kinetic law: MODEL1310110022#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110022#
modifier: MODEL1310110022#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: false
fast: false
product: MODEL1310110022#

metaM dtdp n
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: HMDB01274
initial amount: NaN
has only substance units: false
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
initial concentration: 1.0
is: CHEBI:58369
constant: false
boundary condition: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110022#_43a55e3a_f727_456d_aa8d_2e695c016865
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
name: _T83654_1_e
is: SBO:0000252
is encoded by: hsa:T83654
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110022#_9c0ada88_2587_42ec_9a76_9a9f695967bb
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:7360
initial concentration: NaN
is: Q16851
is: SBO:0000252
name: UGP2
type: Species

metaR CYSTA
kinetic law: MODEL1310110022#
is version of: http://identifiers.org/ec-code/2.6.1.1
name: cysteine transaminase
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.3 Confidence Level: 2 AUTHORS: PMID:15189131,PMID:7113743 NOTES:MM
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110022#
modifier: MODEL1310110022#
product: MODEL1310110022#
is: SBO:0000176

metaM mi14p c
has only substance units: false
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB00968
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:58282
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220

metaM andrstrn r
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB00031
has only substance units: false
name: androsterone
is: CHEBI:16032
initial concentration: 1.0
constant: false
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110022#_daa3b562_8e12_49e2_8c4a_b5cfe276622a
boundary condition: true
has only substance units: false
name: SLC25A4
initial concentration: NaN
is: P12235
type: Species
is: SBO:0000252
is encoded by: hsa:291
constant: false
initial amount: NaN

metaR NACHEX17ly
modifier: MODEL1310110022#
is described by: ECO:0000000
reactant: MODEL1310110022#
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110022#
type: Reaction
kinetic law: MODEL1310110022#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false

metaM dhap e
initial amount: NaN
constant: false
name: glycerone phosphate(2-)
is: SBO:0000247
is: HMDB01473
boundary condition: false
is: CHEBI:57642
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
initial concentration: 1.0
has only substance units: false
type: Species

metaM xol27oh m
boundary condition: false
initial amount: NaN
is: CHEBI:17703
is: SBO:0000247
name: 26-hydroxycholesterol
type: Species
initial concentration: 1.0
is: HMDB02103
has only substance units: false
constant: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340

http://identifiers.org/biomodels.db/MODEL1310110022#_d0305fc8_d59c_4057_a6ce_4655181e2f6b
boundary condition: true
is: SBO:0000252
name: BCKDHB
initial amount: NaN
is: P21953
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:594